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更新于：2025-12-14
Nirmatrelvir
奈玛特韦
更新于：2025-12-14
概要
基本信息
原研机构 |
非在研机构- |
权益机构- |
最高研发阶段临床3期 |
首次获批日期- |
最高研发阶段(中国)- |
特殊审评- |
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结构/序列
分子式C23H32F3N5O4 |
InChIKeyLIENCHBZNNMNKG-OJFNHCPVSA-N |
CAS号2628280-40-8 |
关联
24
项与 奈玛特韦 相关的临床试验NCT05668091
An Interventional Decentralized Phase 2, Randomized, Double-Blind, 2-Arm Study to Investigate the Efficacy and Safety of Orally Administered Nirmatrelvir/Ritonavir Compared with Placebo/Ritonavir in Participants with Long COVID
This decentralized trial is a Phase 2, 1:1 randomized, double-blind, superiority, placebo-controlled study in an anticipated 100 non-hospitalized highly symptomatic adult participants with long COVID. It seeks to determine the efficacy, safety, and tolerability of 15 days of Paxlovid (nirmatrelvir/ritonavir), an anti-viral agent, compared with placebo plus ritonavir. The hypothesis is that viral persistence contributes to long COVID in some patients and nirmatrelvir/ritonavir compared with placebo/ritonavir can improve general health status in participants with long COVID. The study will also seek immune signatures associated with treatment response (overseen by Professor Akiko Iwasaki).
The decentralized study does not require site visits, and participants in all 48 states including the District of Columbia, who meet entry criteria can enroll. It is designed to make it convenient to participate. The study drugs will be delivered to the participant's designated address.
Long COVID is also known as post-acute sequelae of SARS-CoV-2 (PASC).
The decentralized study does not require site visits, and participants in all 48 states including the District of Columbia, who meet entry criteria can enroll. It is designed to make it convenient to participate. The study drugs will be delivered to the participant's designated address.
Long COVID is also known as post-acute sequelae of SARS-CoV-2 (PASC).
开始日期2023-04-14 |
申办/合作机构  Yale University [+1] |
ChiCTR2300068643
A randomized, single center, open label study for azvudine vs Paxlovid treatment for severe COVID-19 patients
开始日期2023-01-16 |
申办/合作机构 |
NCT05545319
AN INTERVENTIONAL EFFICACY AND SAFETY, PHASE 2, DOUBLE-BLIND, 2-ARM STUDY TO INVESTIGATE ORALLY ADMINISTERED NIRMATRELVIR/RITONAVIR COMPARED WITH PLACEBO/RITONAVIR FOR THE TREATMENT OF SEVERE COVID-19 IN HOSPITALIZED PARTICIPANTS WHO ARE IMMUNOCOMPROMISED OR AT INCREASED RISK FOR SEVERE COVID-19 OUTCOMES
A Study to Learn About the Medicine Called Nirmatrelvir Used in Combination With Ritonavir in People with Weakened Immune Systems or at Increased Risk for Poor Outcomes who are Hospitalized Due to Severe COVID-19
开始日期2022-12-13 |
申办/合作机构 |
100 项与 奈玛特韦 相关的临床结果
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100 项与 奈玛特韦 相关的转化医学
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100 项与 奈玛特韦 相关的专利（医药）
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1,406
项与 奈玛特韦 相关的文献（医药）2026-02-01·COMPUTATIONAL BIOLOGY AND CHEMISTRY
Structure-based drug design; Computational strategies in drug discovery; Antihypertensive agents; Antiviral drugs; Molecular docking; QSAR; Pharmacological insights
Review
作者: Fahim, Asmaa M
This review meticulously examines the development, design, and pharmacological assessment of both well known antiviral and antihypertensive medications all time employing new chemical techniques and structure-based drug design to design and synthesize vital therapeutic entities such as aliskiren (renin inhibitor), captopril (a2-ACE-Inhibitor), dorzolamide (inhibitor of carbonic anhydrase) the review demonstrates initial steps regarding the significance of stereoselective synthesis, metal chelating pharmacophores, and rational molecular properties. More importantly, protease inhibitors (i.e., saquinavir, ritonavir, indinavir, amprenavir, etc.) and more contemporary agents (i.e., oseltamivir, nirmatrelvir/ritonavir (Paxlovid), etc.) were identified in the review and form a basis of advancement in antiviral therapy. Using the above-mentioned computational applications (i.e., molecular dockings, structure-activity relationships (SAR)), quantitative structure-activity relationships (QSAR modeling), and ADMET profile information, selectivity, safety, and therapeutic reliability of compounds toward antiviral activity and antihypertensive activity have improved further as outcomes of drug discovery research. Through the combinatorial application of computational drug design and experimental chemistry, researchers have significantly optimized the drug discovery process, minimized off-target effects, and expedited the pathway to develop therapeutically useful medications. In conclusion, this review highlights the transformative power of interdisciplinary approaches, including structure-based design, computational modeling, and the emerging approaches of drug repurposing and virtual screening. This hybrid approach provides a greater opportunity to improve drug therapy for cardiovascular disease and viral infections, and represents the rewards of collaboration.
2025-12-31·JOURNAL OF MEDICAL ECONOMICS
Nirmatrelvir/ritonavir treatment for COVID-19: an economic value systematic literature review
Review
作者: Marcano Belisario, José ; Phan, Nguyen Thi Nhan ; Mugwagwa, Tendai ; Hartley, Louise
AIMS:
Nirmatrelvir/ritonavir (NMV/r) is an antiviral drug used to treat mild-to-moderate coronavirus disease 2019 (COVID-19) in patients at high risk of progression to severe COVID-19. We conducted an economic systematic literature review to assess key parameters, structures, and outcomes of existing models and analyses of the economic value of NMV/r treatment.
METHODS:
A systematic search of Embase, MEDLINE, and MEDLINE In-Process, as well as bibliographies of systematic reviews and conference and health technology assessment websites, identified relevant articles published between 2022 and 2024. A quality assessment was conducted for each economic evaluation using the Drummond checklist.
RESULTS:
Of the 22 included economic evaluations, most were cost-utility analyses (n = 10) and cost-effectiveness analyses (n = 9). Most used a short-term decision tree with a long-term Markov model (n = 5), with time horizons between 28 days to a lifetime, and were from a healthcare system perspective (n = 7). Most conducted scenario analyses (n = 15) and/or sensitivity analyses (n = 18), and many based treatment effectiveness estimates on the Evaluation of Protease Inhibition for COVID-19 in High-Risk Patients (EPIC-HR) randomized controlled trial (n = 7). Overall, NMV/r showed economic value across different willingness-to-pay thresholds when compared with standard of care or best supportive care, and all economic evaluations were high or moderate quality.
LIMITATIONS:
Most included economic evaluations were from high-income countries and all were written in English and may not be generalizable to low-income countries or healthcare systems.
CONCLUSION:
While economic evaluations were heterogeneous in terms of modeling approach, population, treatments, and context, these findings indicate that NMV/r has economic value for patients with mild-to-moderate COVID-19 with a high risk of progression to severe disease. Significant changes to the burden of COVID-19 due to the evolution of COVID-19 variants and new vaccination strategies, may warrant updates models.
2025-12-31·JOURNAL OF MEDICAL ECONOMICS
Cost-effectiveness of outpatient COVID-19 antiviral treatment with nirmatrelvir/ritonavir versus usual care in Swedish patients with various risk factors
Article
作者: Gerdesköld Rappe, Christian ; Aldvén, Martina ; Mugwagwa, Tendai ; Nilsson, Fredrik
AIMS:
Nirmatrelvir/ritonavir (NMV/r) is an orally administered antiviral indicated for the outpatient treatment of adult patients with mild-to-moderate COVID-19 at high risk for disease progression to severe illness. We estimated the cost-effectiveness of NMV/r versus best supportive care for 54 patient cohorts, specified according to age, vaccination status and comorbidity burden.
MATERIALS AND METHODS:
A previously published and validated cost-effectiveness model was utilized and adapted to the Swedish setting. The model used a short-term decision-tree (1 year) followed by a lifetime 2-state Markov model. The short-term decision-tree captured costs and outcomes associated with the primary infection. Post-acute COVID-19 syndrome was only considered in terms of quality-of-life decrements for one year. Baseline hospitalization and mortality risks were taken from a Swedish, nationwide, uniquely granular, Omicron-era, real-world study. NMV/r effectiveness were taken from an Omicron-era US real-world study. Remaining inputs were informed by previous COVID-19 studies and publicly available Swedish sources.
RESULTS:
The incremental cost-effectiveness ratios (ICERs) showed a large variation ranging from almost nine million SEK for some of the youngest cohorts to being dominant (i.e. cost-saving with higher gains in quality-of-life vs standard of care) for twelve elderly cohorts. In general, higher age in combination with non-recent (>180 days) or no vaccination led to lower ICERs. Specifically, NMV/r was cost-effective for all but one patient cohorts at least 70 years old, and for most patient cohorts 60-69 years old.
LIMITATIONS:
As the COVID-19 landscape changes, symptom burden and baseline risks constantly change. Thus, the cost-effectiveness of NMV/r will change with time. However, the future risks could be related to the risks in the current study, and thus remain useful for decision makers.
CONCLUSIONS:
This study shows that NMV/r is a cost-effective or even cost-saving treatment option for many patient cohorts, including most elderly and not-recently vaccinated patients with at least some comorbidity burden.
645
项与 奈玛特韦 相关的新闻（医药）2025-12-13
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截至12月13日15点59分，近期共有 516 本期刊发布了 1042 篇文章，其中糖尿病相关的文章共 423 篇，覆盖 36 个领域的内容。中国专家参与发表的文章有 133 篇。今日，影响因子最高的文章刊登在 Nature medicine (IF: 50.000) 期刊上。
今日头条
Headlines
01 Int J Biol Macromol IF: 08.500 自适应可注射普鲁兰糖/羧甲基壳聚糖水凝胶通过抗菌、促血管生成和免疫调节作用加速糖尿病伤口愈合
Xiao, Zhenyong, Zhao, Hu, Yu, Qiuyi, Luo, Hanwen, Liu, Yan, Liu, Ziying, etc.
糖尿病引起的慢性伤口，因其复杂的病理环境，如持续炎症、易发感染和血管生成障碍，一直是临床治疗中的巨大挑战。近日，一项发表在《International journal of biological macromolecules》上的研究，为这一难题带来了新的解决方案。由研究人员Xiao Zhenyong、Zhao Hu、Yu Qiuyi、Luo Hanwen、Liu Yan、Liu Ziying、Xie Xiangtao和Liu Bo共同完成的研究，成功开发出一种名为PCCCu的多功能自适应可注射水凝胶，该水凝胶在实验中展现出加速糖尿病伤口愈合的显著效果。
该研究的核心是一种创新的水凝胶材料。研究人员将氧化普鲁兰糖与羧甲基壳聚糖（CMCS)通过动态的希夫碱反应进行交联，构建了一个灵活的网络结构。在此基础上，他们进一步将具有抗炎活性的姜黄素和具有抗菌潜力的氧化铜纳米颗粒整合到网络中，最终形成了PCCCu水凝胶。这种设计使得水凝胶不仅具备可注射性，能够轻松填充和贴合不规则的伤口创面，还赋予了其结构上的稳定性，为伤口提供了理想的物理屏障和药物递送平台。
为了全面评估PCCCu水凝胶的效能，研究团队进行了一系列严谨的体外实验。结果显示，该水凝胶具有良好的生物相容性，其溶血率低于5%，表明其对血液细胞的安全性。在对抗细菌感染方面，PCCCu水凝胶表现突出，其抗菌率超过90%，为伤口免受感染提供了有力保障。此外，实验还证实该水凝胶具备强大的促血管生成能力，并能通过调节巨噬细胞极化来调控炎症反应，这恰恰针对了糖尿病伤口愈合过程中炎症失控和血管新生不足的核心问题。
研究的最终验证在糖尿病大鼠模型中进行。动物实验的结果令人鼓舞，应用了PCCCu水凝胶的糖尿病伤口，其愈合过程被显著加速。组织学分析进一步揭示了其作用的深层机制：水凝胶处理后的伤口，上皮化进程更快，新生肉芽组织更丰富，血管再生更为活跃，并且胶原纤维的排列也更趋有序和成熟。这些微观层面的改善，共同促成了宏观上伤口更快更好地闭合。
综上所述，这项研究开发的PCCCu自适应可注射水凝胶，通过其抗菌、促血管生成和免疫调节的多重协同作用，在实验模型中有效促进了糖尿病伤口的愈合。该成果为开发新型糖尿病伤口敷料提供了有价值的思路和实验依据。
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Int J Biol Macromol | Ahead of Print.
10.1016/j.ijbiomac.2025.149616
02 Diabetes Res Clin Pract IF: 07.400 动态血糖监测在临床实践中对使用胰岛素方案的2型糖尿病患者的效用：病例系列与专家意见
一项聚焦于动态血糖监测技术临床应用的最新综述与专家意见，为使用胰岛素治疗的2型糖尿病患者的精准管理提供了实用指引。这项工作的核心在于，针对亚洲地区相关临床指导相对缺乏的现状，通过结合真实病例与专家分析，旨在帮助临床医生更有效地利用这一技术。
该文章明确指出，对于依赖胰岛素的2型糖尿病患者，动态血糖监测能够提供传统指尖血糖检测难以获取的连续血糖信息，清晰揭示患者全天的血糖波动模式。这不仅有助于医生精细化调整胰岛素剂量和用药方案，还能为患者选择饮食、运动等生活方式提供直观依据，同时免去了频繁扎手指带来的痛苦与不便。
值得关注的是，文章特别区分了三种常见的临床场景进行深入探讨。首先是身体状况相对简单、没有其他严重合并症的患者；其次是同时伴有高血压、血脂异常等心血管疾病风险因素的患者；第三则是需要特别关注的老年糖尿病患者群体。针对每一类人群，动态血糖监测的应用重点和考量均有不同。
为了将理论转化为实践，文中精心展示了五个经过匿名处理的真实临床病例。这些案例均附有详细的动态葡萄糖图谱，生动演示了如何解读数据，并基于数据发现的问题来调整治疗策略，从而改善患者的血糖控制结局。这些来自临床一线的实例，为同行提供了极具参考价值的操作范本。
基于病例分析与现有文献依据，专家们系统阐述了动态血糖监测在上述不同患者群体中能够带来的多重获益。其价值不仅局限于优化降糖效果，更延伸到通过预防和及时处理低血糖事件来提升治疗安全性，并最终改善患者的治疗体验与长期生活质量。
综合所有讨论，文章的最终产出是一份包含十项要点的核心临床实践建议清单。这些建议旨在全方位指导临床工作者，更科学地运用动态血糖监测技术，以实现个体化的血糖控制目标，优化胰岛素治疗方案，增强患者对健康生活方式的执行力，最大程度降低低血糖风险，从而全面守护患者的健康与福祉。
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Diabetes Res Clin Pract | Ahead of Print.
10.1016/j.diabres.2025.113054
03 Drug delivery IF: 08.100 无针注射器与胰岛素笔在糖尿病管理中的有效性、安全性及以患者为中心的结局：一项全面荟萃分析
Wang, Jing, Chen, Xinhao, Ge, Zhili, Xia, Yingran, Tang, Zixiang, Sun, Zehao, etc.
一项近期发表于《Drug delivery》期刊的全面荟萃分析，为糖尿病患者的胰岛素注射方式提供了新的循证依据。该研究系统比较了无针注射器与传统胰岛素笔在治疗效果、安全性和患者感受方面的差异。
这项研究由Wang Jing, Chen Xinhao等多位研究者共同完成。为了获得可靠的结论，研究团队系统检索了截至2024年6月，发表在CNKI、Weipu、PubMed等多个主流中英文数据库中的相关随机对照试验。最终，共计22项符合标准的研究被纳入分析，这些研究共涉及2580名糖尿病患者，其中使用无针注射器与胰岛素笔的患者各占一半，均为1290名。
分析结果显示，在控制血糖的核心指标上，无针注射器展现出了一定优势。与使用胰岛素笔的患者相比，使用无针注射器的患者其糖化血红蛋白、空腹血糖以及餐后2小时血糖的下降程度更为显著。这表明，在改善血糖水平方面，无针注射器可能是一种更有效的给药工具。
在安全性方面，研究评估了局部和全身两种类型的风险。在注射局部，无针注射器相关的皮肤不良反应发生率更低。而在全身性风险方面，最为患者关注的低血糖事件，其发生率在两组之间并无统计学上的显著差异，提示两种注射方式的系统性安全风险可能相近。
除了客观的临床指标，研究还关注了患者的主观体验。分析发现，患者对无针注射器的接受度和满意度普遍高于传统的胰岛素笔。这提示，减少或避免针头使用可能从心理和使用感受层面改善患者的治疗体验。
然而，研究也指出了一些未观察到显著差异的领域。例如，在反映日内血糖波动的持续血糖监测相关指标上，两种注射方式并未体现出明显区别。研究者表示，这意味着无针注射器对血糖稳定性的长期影响，仍需更多研究来明确。
综合来看，这项荟萃分析表明，对于需要胰岛素治疗的糖尿病患者，无针注射器在改善部分关键血糖指标、减少局部皮肤反应以及提升患者治疗体验方面可能优于传统胰岛素笔。研究结果为临床选择个体化的胰岛素注射方式提供了参考，但研究者也强调，其长期疗效和安全性仍有待进一步验证。
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Drug delivery | Volume 32, Issue 1
10.1080/10717544.2025.2597906
04 Hepatobiliary Surg Nutr IF: 07.800 评估2型糖尿病中代谢功能障碍相关脂肪性肝病的风险：Fibrosis-4指数仍是可靠工具吗？
Yoneda, Masato, Kobayashi, Takashi, Iwaki, Michihiro, Wada, Naohiro, Nogami, Asako, Nakajima, Atsushi, etc.
近期发表于《Clinical and Molecular Hepatology》的一项重磅荟萃分析，对广泛应用于肝纤维化评估的FIB-4指数在2型糖尿病（T2DM）人群中的可靠性提出了重要质疑。该研究由Han等人完成，系统评估了FIB-4在鉴别T2DM合并代谢功能障碍相关脂肪性肝病（MASLD）患者晚期肝纤维化方面的诊断性能。
研究发现，当使用临床常用的FIB-4低阈值（1.3至1.67）进行筛查时，其排除晚期纤维化的能力——即阴性预测值（NPV）仅为0.82。这一数值低于通常认为足以确保临床信心的0.90门槛。这意味着，即使在FIB-4评分被认为是“低风险”的T2DM患者中，仍有相当一部分人可能实际存在需要关注的晚期肝纤维化，从而面临漏诊风险。
研究进一步揭示，问题在晚期纤维化患病率较高的人群中尤为突出。众所周知，T2DM患者是肝纤维化快速进展的高危群体，其晚期纤维化的患病率可能显著高于普通人群。该分析模拟显示，当患病率上升到30%至50%的范围内时，FIB-4的阴性预测值会急剧下降至0.70以下。这一数据强烈提示，在当前指南推荐的使用FIB-4作为初筛工具的策略下，大量本应被识别出来的高风险T2DM患者可能被错误地归类，从而错失早期干预和专科转诊的时机。
另一方面，当采用较高的FIB-4阈值（2.67至3.25）时，虽然确诊能力很强——特异性高达0.92，阳性预测值达到0.70，但其发现疾病的能力却非常有限，灵敏度低至0.33。这表明高阈值不适用于广泛的筛查目的，因为它会漏掉超过三分之二的晚期纤维化病例。
该荟萃分析共纳入了12项研究，涉及全球范围内5624名经肝脏活检确诊的T2DM合并MASLD患者，确保了结论的广泛代表性和可靠性。分析还指出，患者年龄、更晚期纤维化的比例等因素可能进一步影响FIB-4的准确性，强调了对这一人群需要更个体化的评估方法。
这些发现对广大初级保健医生、内分泌科医生及肝病科医生具有直接的实践意义。它警示临床工作者，对于T2DM患者，单纯依赖FIB-4指数可能不足以安全地排除严重的肝脏疾病。研究团队在文中强调，当前的临床管理路径可能需要调整，例如考虑对T2DM患者采用更低的FIB-4阈值来触发进一步检查，或者更频繁地进行FIB-4评估。
同时，研究支持了当前国际指南中已提及的补充策略的重要性，即在FIB-4初筛后，对于不确定或高危的患者，应积极采用第二线评估工具。这包括诸如振动控制瞬时弹性成像（VCTE）、血清学标志物如增强肝纤维化（ELF）检测，或在亚洲地区应用日益广泛的Mac-2结合蛋白糖基化异构体（M2BPGi）等。开发融合了T2DM特异性风险因素（如血糖控制情况）的新型纤维化评分系统，也被认为是未来的重要方向。
随着全球T2DM和MASLD患病率的持续攀升，如何在资源有限的情况下精准识别出肝病进展风险最高的个体，已成为公共卫生和临床医学面临的关键挑战。这项研究为优化这一高风险人群的肝纤维化筛查策略提供了关键的循证依据，呼吁学界和临床界共同审视并完善现有实践。
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Hepatobiliary Surg Nutr | Volume 14, Issue 6
10.21037/hbsn-2025-439
05 Diabetology & metabolic syndrome IF: 03.900 代谢控制对2型糖尿病合并慢性多支冠状动脉疾病患者心血管结局的影响：一项队列研究
Andrade, Vitor Coutinho, Rezende, Paulo Cury, Hueb, Whady, Garcia, Rosa Maria Rahmi, de Assis, Arthur Cicupira Rodrigues, da Silva, Marcela Francisca, etc.
一项发表在Diabetology & metabolic syndrome上的研究，深入探讨了代谢控制水平对于2型糖尿病合并慢性多支冠状动脉疾病患者长期心血管健康的关键影响。该研究由Andrade, Vitor Coutinho、Rezende, Paulo Cury、Hueb, Whady等研究者共同完成。
研究团队回顾性分析了自1995年至2010年间纳入的884名患者数据，最终筛选出718名符合条件的研究对象进行深入分析。这些患者平均年龄为61岁，其中女性占比35.3%。研究的核心在于评估低密度脂蛋白胆固醇、糖化血红蛋白和甘油三酯这三项关键代谢指标的控制情况与心血管结局之间的关联。根据指标达标数量，患者被分为四个组别进行长期随访，平均随访时间长达8年。
分析结果显示，患者代谢控制情况分布如下：27.8%的患者三项指标均控制在目标范围内，36.2%的患者有两项达标，24.3%的患者仅一项达标，而11.7%的患者则三项指标均未达标。研究团队在调整了年龄、性别、吸烟状况、射血分数、病变血管数量及初始治疗方案等多种潜在混杂因素后，进行了严谨的统计分析。
研究发现了一个清晰的趋势：代谢指标控制得越差，主要不良心血管事件的发生风险就越高，呈现出显著的“剂量-反应”关系。具体而言，与三项指标全部达标的患者群体相比，那些没有任何一项指标达标的患者，在长期随访中遭遇全因死亡、心肌梗死、卒中或非计划性血运重建等复合终点的风险增加了近三倍，其风险比高达2.87。
这项研究通过长期的队列数据表明，对于已经确诊为稳定型冠状动脉疾病和2型糖尿病的患者而言，持续、综合地管理好血脂和血糖等代谢指标，对于降低未来发生严重心血管事件的风险具有明确的临床重要性。研究结果强调了在这一高危人群中实施全面风险管理策略的必要性。
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Diabetology & metabolic syndrome | Ahead of Print.
10.1186/s13098-025-02027-6
中国发表（133）
China
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Advanced science IF: 14.100Ahead of Print.No.11Colorectal Cancer Cell's Weapon: RNF32 Engages SPP1(+) Macrophages to Foster Liver Metastasis, Targeted by Indole-3-Acetic Acid结直肠癌细胞的武器：RNF32募集SPP1阳性巨噬细胞促进肝转移，吲哚-3-乙酸可靶向干预DOI: 10.1002/advs.202519735
J Genet Eng Biotechnol IF: 02.800Volume 23, Issue 4No.12Bioinformatics and experimental validation of MAPK pathway activation in diabetic kidney disease induced by glucose variability血糖波动诱导的糖尿病肾病中MAPK通路激活的生物信息学与实验验证DOI: 10.1016/j.jgeb.2025.100598
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BMC urology IF: 01.900Ahead of Print.No.15Association between red cell distribution width-to-albumin ratio and risk of diabetic kidney disease: a cross-sectional NHANES study红细胞分布宽度与白蛋白比值与糖尿病肾病风险的相关性：一项基于NHANES的横断面研究DOI: 10.1186/s12894-025-02009-w
Nature communications IF: 15.700Ahead of Print.No.16Genetic profiling of the circulating proteome in common diseases suggests causal proteins and improves risk prediction常见疾病中循环蛋白质组的遗传图谱分析提示致病蛋白并提升风险预测效能DOI: 10.1038/s41467-025-67238-x
Pediatric research IF: 03.100Ahead of Print.No.17Sleep heterogeneity in adolescents with type 1 diabetes: correlations with glycemic control, stigma, and resilience青少年1型糖尿病患者的睡眠异质性：与血糖控制、病耻感及心理韧性的相关性研究DOI: 10.1038/s41390-025-04644-3
Nature communications IF: 15.700Ahead of Print.No.18Hyperglycemia exacerbates osteoarthritis by impairing macrophage efferocytosis through modulation of CD11b lactylation高血糖通过CD11b乳酸化修饰损伤巨噬细胞胞葬作用加剧骨关节炎DOI: 10.1038/s41467-025-67473-2
Obesity reviews IF: 07.400Ahead of Print.No.19Circulating Proteins Link Obesity With Cardiac Remodeling: Insights From Mendelian Randomization循环蛋白连接肥胖与心脏重塑：孟德尔随机化研究的启示DOI: 10.1111/obr.70059
Nano letters IF: 09.100Ahead of Print.No.20Programming Molecular Switches within Capacitive PEDOT:DNA Hydrogels for Deciphering Pathophysiological Microenvironment Dynamics in Diabetic Wound在电容式PEDOT:DNA水凝胶中编程分子开关用于解码糖尿病伤口病理生理微环境动态DOI: 10.1021/acs.nanolett.5c05009
J Neurointerv Surg IF: 04.300Ahead of Print.No.21Safety and efficacy of sequential intra-arterial and intravenous administration of tirofiban during the periprocedural period of stenting in perforator-rich intracranial arteries穿支丰富颅内动脉支架围手术期序贯动脉内与静脉内应用替罗非班的安全性与有效性DOI: 10.1136/jnis-2025-024471
Int J Biol Macromol IF: 08.500Ahead of Print.No.22Adaptive injectable pullulan/carboxymethyl chitosan hydrogel accelerates diabetic wound healing through antibacterial, angiogenic, and immunomodulatory effects自适应可注射普鲁兰糖/羧甲基壳聚糖水凝胶通过抗菌、促血管生成和免疫调节作用加速糖尿病伤口愈合DOI: 10.1016/j.ijbiomac.2025.149616
European journal of pharmacology IF: 04.700Ahead of Print.No.23Metformin's Hidden Power: Unveiling Its Role in Melanoma Suppression Through endo-lysosome pH and Autophagy Regulation二甲双胍的隐藏力量：通过内溶酶体pH与自噬调控揭示其在黑色素瘤抑制中的作用DOI: 10.1016/j.ejphar.2025.178438
Fitoterapia IF: 02.600Ahead of Print.No.24Amide alkaloids from the fruits of Piper longum L. and their bioactivities长果胡椒果实中酰胺生物碱的分离鉴定及其生物活性研究DOI: 10.1016/j.fitote.2025.107024
Fitoterapia IF: 02.600Ahead of Print.No.25Integrating mouse oral trial, LC-HRMS-based untargeted metabolomics and network pharmacology for screening bioactive components of Astragalus membranaceus curing type-II diabetes mellitus (T2DM)整合小鼠口服试验、LC-HRMS非靶向代谢组学与网络药理学技术筛选黄芪治疗2型糖尿病的生物活性成分DOI: 10.1016/j.fitote.2025.107033
Arch Biochem Biophys IF: 03.000Ahead of Print.No.26LncRNA SNHG6 Attenuates Ferroptosis in High Glucose-treated Renal Tubular Epithelial Cells by Stabilizing YY1 to Activate the PI3K/AKT/GSK-3β PathwayLncRNA SNHG6通过稳定YY1激活PI3K/AKT/GSK-3β通路减轻高糖处理的肾小管上皮细胞铁死亡DOI: 10.1016/j.abb.2025.110702
Phytomedicine IF: 08.300Ahead of Print.No.27Safranal accelerates diabetic wound healing by suppressing ferroptosis through modulation of transcription factor Forkhead Box O3藏花醛通过调节转录因子Forkhead Box O3抑制铁死亡从而加速糖尿病伤口愈合DOI: 10.1016/j.phymed.2025.157675
Phytomedicine IF: 08.300Ahead of Print.No.28Corylin ameliorates diabetic osteoporosis by inhibiting inflammation via targeting RAG1Corylin通过靶向RAG1抑制炎症改善糖尿病骨质疏松症DOI: 10.1016/j.phymed.2025.157671
Phytomedicine IF: 08.300Ahead of Print.No.29Swietenine attenuates renal tubular injury by activating mitophagy in diabetic nephropathySwietenine通过激活线粒体自噬减轻糖尿病肾病的肾小管损伤DOI: 10.1016/j.phymed.2025.157668
Biomedicine & pharmacotherapy IF: 07.500Ahead of Print.No.30Chiglitazar, a PPAR pan-agonist: Impacts on type 2 diabetes mellitus and multi-system metabolic regulation - A reviewPPAR泛激动剂Chiglitazar：对2型糖尿病及多系统代谢调节的影响——一篇综述DOI: 10.1016/j.biopha.2025.118850
Cell reports IF: 06.900Ahead of Print.No.31Tracing the origin of testosterone-producing Leydig cells during pubertal development, homeostasis, and regeneration追踪睾酮生成Leydig细胞在青春期发育、稳态和再生过程中的起源DOI: 10.1016/j.celrep.2025.116674
J Diabetes Investig IF: 03.000Ahead of Print.No.32FGF11 regulated by CTBP1-AS2/miR-520a-5p/miR-432-5p axis inhibits the progression and angiogenesis in high glucose-treated human microvascular endothelial cellsCTBP1-AS2/miR-520a-5p/miR-432-5p轴调控的FGF11抑制高糖处理的人微血管内皮细胞的进展与血管生成DOI: 10.1111/jdi.13990
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Skin research and technology IF: 03.200Volume 31, Issue 12No.35Clinical Characteristics of Plantar Warts and Association With BMI: A Retrospective Case Series Study跖疣的临床特征及其与BMI的关联：一项回顾性病例系列研究DOI: 10.1111/srt.70303
Gut microbes IF: 11.000Volume 17, Issue 1No.36Helicobacter pylori infection aggravates hepatic steatosis by lactylation-driven WTAP-mediated m(6)A modification幽门螺杆菌感染通过乳酸化驱动的WTAP介导的m6A修饰加重肝脏脂肪变性DOI: 10.1080/19490976.2025.2599543
Gynecological endocrinology IF: 01.700Volume 41, Issue 1No.37A review of immunometabolic crosstalk in PCOS-related pregnancy loss: mechanisms and emerging therapeutic strategiesPCOS相关流产中免疫代谢串扰的综述：机制与新兴治疗策略DOI: 10.1080/09513590.2025.2600160
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Breast Cancer Res Treat IF: 03.000Volume 215, Issue 1No.39Risk factors for postoperative bleeding following breast cancer surgery: a systematic review and meta-analysis乳腺癌术后出血的风险因素：一项系统评价与荟萃分析DOI: 10.1007/s10549-025-07849-6
Molecular biology reports IF: 02.800Volume 53, Issue 1No.40Exploration of common therapeutic targets for diabetic nephropathy and diabetic foot ulcers by integrated bioinformatics analysis and experimental validation整合生物信息学分析与实验验证探索糖尿病肾病和糖尿病足溃疡的共同治疗靶点DOI: 10.1007/s11033-025-11350-0
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JMIR serious games IF: 04.100Volume 13, Issue No.44Development and Evaluation of a Monocular Camera-Based Mobile Exergame for at-Home Intervention in Individuals at High Risk of Type 2 Diabetes: Randomized Controlled Trial开发与评估基于单目摄像头的移动体感游戏用于2型糖尿病高风险人群的家庭干预：一项随机对照试验DOI: 10.2196/75823
Journal of materials chemistry IF: 05.700Ahead of Print.No.45A multifunctional composite hydrogel with natural polymer silk fibroin and gelatin for promoting chronic wound healing一种用于促进慢性伤口愈合的含天然聚合物丝素蛋白和明胶的多功能复合水凝胶DOI: 10.1039/d5tb02034d
Endocrine connections IF: 02.800Ahead of Print.No.46Real-world Pharmacovigilance Study of Drug-induced Diabetes Insipidus from the FAERS Database基于FAERS数据库的药物性尿崩症真实世界药物警戒研究DOI: 10.1530/EC-25-0734
Journal of global health IF: 04.300Volume 15, Issue No.47Longitudinal insights into comorbidity patterns and burden among middle-aged and older adults with diabetes in China: a nine-year cohort study using CHARLS中国中老年糖尿病患者合并症模式与负担的纵向洞察：一项基于CHARLS的九年队列研究DOI: 10.7189/jogh.15.04353
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Drug delivery IF: 08.100Volume 32, Issue 1No.49Efficacy, safety, and patient-centered outcomes of needle-free injectors versus insulin pens in diabetes management: a comprehensive meta-analysis无针注射器与胰岛素笔在糖尿病管理中的有效性、安全性及以患者为中心的结局：一项全面荟萃分析DOI: 10.1080/10717544.2025.2597906
The Journal of headache and pain IF: 07.900Volume 26, Issue 1No.50L3MBTL2 as a novel therapeutic target for trigeminal neuralgia: evidence from integrated TWAS, multi-tissue MR, and experimental validationL3MBTL2作为三叉神经痛的新治疗靶点：来自TWAS、多组织MR及实验验证的证据DOI: 10.1186/s10194-025-02218-6
Journal of pain research IF: 02.500Volume 18, Issue No.51Causal Relationships Between Neuropathic Pain and Alzheimer's Disease: A Multi-Omics Mendelian Randomization Study with Exploratory Evidence of a Potential Protective Role of Diabetic Neuropathy神经病理性疼痛与阿尔茨海默病之间的因果关系：一项结合多组学孟德尔随机化与糖尿病神经病变潜在保护作用的探索性证据研究DOI: 10.2147/JPR.S554433
Frontiers in public health IF: 03.400Volume 13, Issue No.52Multimorbidity patterns and cognitive frailty in adults aged over 50 years: China perspective中国50岁以上成年人的多重慢病模式与认知衰弱DOI: 10.3389/fpubh.2025.1701955
Future medicinal chemistry IF: 03.400Ahead of Print.No.53Small molecule inhibitors of HG-induced VEC ferroptosis: synthetic advances and therapeutic applications高血糖诱导的血管内皮细胞铁死亡的小分子抑制剂：合成进展与治疗应用DOI: 10.1080/17568919.2025.2602422
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.54Accurate screening of patients with diabetes based on physical examination: pancreas imaging features from chest CT and laboratory data基于体检的糖尿病患者精准筛查：胸部CT胰腺影像特征与实验室数据DOI: 10.3389/fendo.2025.1698247
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.55Prediction model for cognitive impairment in maintenance hemodialysis patients: the role of diabetes维持性血液透析患者认知功能损害的预测模型：糖尿病的作用DOI: 10.3389/fendo.2025.1594605
Risk Manag Healthc Policy IF: 02.000Volume 18, Issue No.56Analysis of Risk Factors of Postoperative Dry Eye in Cataract Patients Based on Lens Nucleus Hardness Grading基于晶状体核硬度分级的白内障患者术后干眼危险因素分析DOI: 10.2147/RMHP.S565376
Frontiers in immunology IF: 05.900Volume 16, Issue No.57Tumor-associated Tn and STn antigens: from molecular mechanism to precision diagnosis and treatment肿瘤相关Tn与STn抗原：从分子机制到精准诊疗DOI: 10.3389/fimmu.2025.1660852
Frontiers in nutrition IF: 05.100Volume 12, Issue No.58Comprehensive assessment of dietary micronutrient profiles and their effects on hemoglobin levels and anemia: provincial nutrition and health monitoring膳食微量营养素谱及其对血红蛋白水平与贫血影响的综合评估：省级营养与健康监测DOI: 10.3389/fnut.2025.1638705
Frontiers in nutrition IF: 05.100Volume 12, Issue No.59Association between geriatric nutritional risk index and fecal incontinence in individuals with stroke: mediating roles of systemic immune inflammation index and oxidative balance scores老年营养风险指数与卒中患者大便失禁的关联：系统免疫炎症指数和氧化平衡评分的中介作用DOI: 10.3389/fnut.2025.1692314
ACS Appl Mater Interfaces IF: 08.200Ahead of Print.No.60Mitochondrial-Targeting Drug-Loaded Nanoparticles Reprogram Macrophage Metabolism via ROS/NO Co-elimination for Diabetic Wound Healing线粒体靶向载药纳米颗粒通过ROS/NO共消除重编程巨噬细胞代谢促进糖尿病伤口愈合DOI: 10.1021/acsami.5c19664
ACS nano IF: 16.000Ahead of Print.No.61Anchoring Sn-Containing High-Entropy Alloy PtFeCoNiCuSn on SnO(2) for Improving Acetone Detection Ability将含锡高熵合金PtFeCoNiCuSn锚定在SnO2上以提升丙酮检测能力DOI: 10.1021/acsnano.5c15097
ACS sensors IF: 09.100Ahead of Print.No.62An Ant-Nest-Structured Wearable Sensor with pH Calibration for Reliable Monitoring of Sweat Glucose一种集成pH校准的蚁巢结构可穿戴传感器用于汗液葡萄糖可靠监测DOI: 10.1021/acssensors.5c03084
Zhong Nan Da Xue Xue Bao Yi Xue BanVolume 50, Issue 8No.63[Latent profile types and influencing factors of medication adherence mechanisms among rural older adults with multiple chronic conditions]农村多重慢病老年人用药依从性机制的潜在剖面类型及影响因素研究DOI: 10.11817/j.issn.1672-7347.2025.250141
Molecular Medicine Reports IF: 03.500Volume 33, Issue 2No.64Influence and treatment of insulin receptor substrate/PI3K/Akt‑mediated insulin resistance in diabetes mellitus (Review)胰岛素受体底物/PI3K/Akt介导的胰岛素抵抗在糖尿病中的影响与治疗DOI: 10.3892/mmr.2025.13773
Biomedical reports IF: 01.900Volume 24, Issue 2No.65ERp46 mitigates lipotoxic ER stress to preserve GLUT2 expression and insulin secretion in β-cellsERp46缓解脂毒性内质网应激以维持β细胞中GLUT2的表达和胰岛素分泌DOI: 10.3892/br.2025.2095
Ecology and evolution IF: 02.300Volume 15, Issue 12No.66Brain Transcriptomics Reveals Molecular Mechanisms of Cave Adaptation in Triplophysa Loaches脑转录组学揭示高原鳅洞穴适应的分子机制DOI: 10.1002/ece3.72652
J Am Chem Soc IF: 15.600Ahead of Print.No.67Small-Molecule Fe(3+)-Based Magnetic Resonance Imaging Probe Enables Noninvasive Imaging of Pancreatic Zn(2+) and β-Cell Function In Vivo基于小分子Fe(3+)的磁共振成像探针实现胰腺Zn(2+)及β细胞功能的体内无创成像DOI: 10.1021/jacs.5c17216
FCVM IF: 02.900Volume 12, Issue No.68Combined effects of insulin resistance and altitude of residence on 10-year risk of atherosclerotic cardiovascular disease胰岛素抵抗与居住海拔对动脉粥样硬化性心血管疾病10年风险的联合影响DOI: 10.3389/fcvm.2025.1656537
Food science & nutrition IF: 03.800Volume 13, Issue 12No.69Takeaway Food Consumption, Dietary Inflammatory Index, and Cardiometabolic Risk Factors in US Adults: Findings From NHANES (2009-2018)美国成年人外卖食品摄入、膳食炎症指数与心脏代谢风险因素：来自NHANES (2009-2018)的发现DOI: 10.1002/fsn3.71316
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.70Comparative analysis of the therapeutic effect of antibiotic bone cement on Wagner grade 3 or 4 diabetic foot ulcer in heel and non-heel areas: a retrospective cohort study抗生素骨水泥治疗足跟与非足跟区Wagner 3或4级糖尿病足溃疡的疗效比较：一项回顾性队列研究DOI: 10.3389/fendo.2025.1662731
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.71Transcriptomic profiling of diabetic retinopathy: insights into RPL11 and bisphenol A糖尿病视网膜病变的转录组学分析：聚焦RPL11与双酚ADOI: 10.3389/fendo.2025.1705233
Int J Nanomedicine IF: 06.500Volume 20, Issue No.72Mesenchymal Stem Cell-Derived Exosomes for Ocular Diseases: Therapeutic Mechanisms and Clinical Perspectives间充质干细胞来源的外泌体在眼部疾病中的应用：治疗机制与临床前景DOI: 10.2147/IJN.S555771
Exp Ther Med IF: 02.300Volume 31, Issue 2No.73Outcomes of anti-VEGF therapy compared with conventional interventions in diabetic retinopathy management抗血管内皮生长因子疗法与传统干预在糖尿病视网膜病变管理中的疗效对比DOI: 10.3892/etm.2025.13028
Organic letters IF: 05.000Ahead of Print.No.74NiCl(2)/Hdipm-Catalyzed 2-OH-Selective Alkylation of Glycoside trans-DiolsNiCl₂/Hdipm催化的糖苷反式二醇2-OH选择性烷基化DOI: 10.1021/acs.orglett.5c04886
Exp Ther Med IF: 02.300Volume 31, Issue 2No.75The influence of fetal sex on preterm birth risk in gestational diabetes mellitus: A retrospective cohort study胎儿性别对妊娠期糖尿病孕妇早产风险的影响：一项回顾性队列研究DOI: 10.3892/etm.2025.13034
NeuroprotectionVolume 3, Issue 1No.76Advancing neuroprotection and atherosclerosis prevention through familial hypercholesterolemia management: Analyzing comorbidity burden with stroke, coronary heart disease, hypertension, and diabetes通过管理家族性高胆固醇血症推动神经保护与动脉粥样硬化预防：分析其与卒中、冠心病、高血压和糖尿病的合并症负担DOI: 10.1002/nep3.72
Frontiers in physiology IF: 03.400Volume 16, Issue No.77Association between body mass index at different levels and risk of gastroesophageal reflux disease: a systematic review with dose-response meta-analysis不同水平的体重指数与胃食管反流病风险之间的关联：一项采用剂量反应Meta分析的系统评价DOI: 10.3389/fphys.2025.1675457
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.78Combination metformin and liraglutide in PCOS: clinical efficacy in women and preclinical insights from gut microbiome modulation in rats二甲双胍联合利拉鲁肽治疗PCOS：在女性中的临床有效性及其通过调节肠道微生物组获得的临床前洞见DOI: 10.3389/fendo.2025.1599879
Hepatobiliary Surg Nutr IF: 07.800Volume 14, Issue 6No.79From NAFPD to MAFPD: a literature review of implications of a nomenclature change从NAFPD到MAFPD：命名变更影响的文献综述DOI: 10.21037/hbsn-24-284
Frontiers in nutrition IF: 05.100Volume 12, Issue No.80Dietary patterns and obesity are associated with type 2 diabetes risk in elderly Chinese men: a machine learning approach饮食模式与肥胖和中国老年男性2型糖尿病风险相关：一项机器学习方法研究DOI: 10.3389/fnut.2025.1705683
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.81Association between vascular aging and cardiovascular-kidney-metabolic syndrome血管老化与心血管-肾脏-代谢综合征（CKM）的关联DOI: 10.3389/fendo.2025.1665836
Experimental Eye Research IF: 02.700Ahead of Print.No.82Canagliflozin inhibits NLRP3 Inflammasome activation to protect the Retinal Neurovascular Unit in a Mouse Retinal Vein Occlusion Model卡格列净通过抑制NLRP3炎症小体活化保护小鼠视网膜静脉阻塞模型中的视网膜神经血管单元DOI: 10.1016/j.exer.2025.110803
BMC geriatrics IF: 03.800Ahead of Print.No.83eHealth literacy mediates self-advocacy and self-management in older adults with diabetes电子健康素养在老年糖尿病患者自我倡导与自我管理中的中介作用DOI: 10.1186/s12877-025-06859-9
Hereditas : IF: 02.500Ahead of Print.No.84CD248, targeted by veratramine and neobavaisoflavone, mediates pathological changes of renal tubular epithelial cells induced by high glucoseCD248介导高糖诱导的肾小管上皮细胞病理变化，是黎芦胺和新巴伐异黄酮的作用靶点DOI: 10.1186/s41065-025-00624-z
Stem cell research & therapy IF: 07.300Ahead of Print.No.85Mesenchymal stem cell-derived extracellular vesicles for disease therapy by regulating ferroptosis: focus on diabetes mellitus and diabetic complications靶向铁死亡：间充质干细胞来源的细胞外囊泡的疾病治疗潜力——聚焦糖尿病及其并发症DOI: 10.1186/s13287-025-04852-y
Eur J Med Res IF: 03.400Ahead of Print.No.86Risk factors associated with bone cement leakage following percutaneous kyphoplasty: a retrospective analysis经皮椎体后凸成形术后骨水泥渗漏的相关风险因素：一项回顾性分析DOI: 10.1186/s40001-025-03608-x
Eur J Med Res IF: 03.400Ahead of Print.No.87A predictive nomogram for hemorrhage risk following endoscopic submucosal dissection of gastrointestinal tumors: a retrospective cohort study预测胃肠道肿瘤内镜黏膜下剥离术后出血风险的列线图模型：一项回顾性队列研究DOI: 10.1186/s40001-025-03599-9
Genome medicine IF: 11.200Ahead of Print.No.88Transcriptome-wide association study revealed novel causal genes of renal-biopsy proven diabetic nephropathy全转录组关联研究揭示肾活检确诊的糖尿病肾病新型致病基因DOI: 10.1186/s13073-025-01590-x
BMC ophthalmology IF: 01.700Ahead of Print.No.89Effects of blood pressure and blood glucose levels on foveal avascular zone area血压与血糖水平对黄斑无血管区面积的影响DOI: 10.1186/s12886-025-04534-6
BMC Cardiovascular Disorders IF: 02.300Ahead of Print.No.90Independent risk factors of hypertension in patients with chronic heart failure: insights from univariate and multivariate analyses慢性心力衰竭患者高血压的独立危险因素：基于单因素与多因素分析的启示DOI: 10.1186/s12872-025-05408-x
Scientific reports IF: 03.900Ahead of Print.No.91Long-term real-world performance of the Bayer Contour TS point-of-care testing glucose meters拜安捷血糖仪长期真实世界性能评估DOI: 10.1038/s41598-025-30850-4
Nature communications IF: 15.700Volume 16, Issue 1No.92Artificial intelligence-driven metabolomics of retinal nerve fibre layer to profile risks of mortality and cardiometabolic diseases人工智能驱动的视网膜神经纤维层代谢组学解析死亡与心脏代谢疾病风险DOI: 10.1038/s41467-025-66979-z
Food chemistry IF: 09.800Ahead of Print.No.93Synergistic effects of endogenous protein components and starch molecular structure on physicochemical, rheological and digestive properties in rice内源性蛋白组分与淀粉分子结构的协同作用对水稻理化、流变及消化特性的影响DOI: 10.1016/j.foodchem.2025.147443
Phytomedicine IF: 08.300Ahead of Print.No.94Multi-level intervention of Tangluoning on mitochondrial thioredoxin deficiency in Schwann cells ameliorates diabetic peripheral neuropathy汤剂Tangluoning对雪旺细胞线粒体硫氧还蛋白缺乏的多层次干预改善糖尿病周围神经病变DOI: 10.1016/j.phymed.2025.157656
Biochemical pharmacology IF: 05.600Ahead of Print.No.95RIPK3 deficiency ameliorates diabetic sarcopenia through proteostasis regulation by suppressing inflammatory signaling and cellular stress pathwaysRIPK3缺乏通过抑制炎症信号和细胞应激通路调节蛋白质稳态改善糖尿病肌肉减少症DOI: 10.1016/j.bcp.2025.117627
BMC endocrine disorders IF: 03.300Ahead of Print.No.96Comparison of logistic regression and artificial neural network models for predicting hypoglycemia in non-ICU inpatients with diabetes预测非ICU糖尿病患者低血糖：逻辑回归与人工神经网络模型的比较DOI: 10.1186/s12902-025-02125-6
Diabetologia IF: 10.200Ahead of Print.No.97LDHA induces beta cell dedifferentiation in diabetes through metabolic and epigenetic reprogrammingLDHA通过代谢与表观遗传重编程诱导糖尿病中的β细胞去分化DOI: 10.1007/s00125-025-06626-w
Molecular & cellular proteomics IF: 05.500Ahead of Print.No.98Plasma Proteomic Characterization of Adolescent Idiopathic Scoliosis青少年特发性脊柱侧凸的血浆蛋白质组特征DOI: 10.1016/j.mcpro.2025.101486
Biochem Biophys Res Commun IF: 02.200Ahead of Print.No.99Engineered MSCs secreting GLP-1 enhance β-cell survival and improve glycemic control in diabetic mice分泌GLP-1的工程化间充质干细胞增强β细胞存活并改善糖尿病小鼠血糖控制DOI: 10.1016/j.bbrc.2025.153105
Scientific reports IF: 03.900Volume 15, Issue 1No.100Information quality assessment and user engagement prediction of short videos about diabetic kidney disease on TikTok and bilibili抖音与哔哩哔哩平台上糖尿病肾病相关短视频的信息质量评估与用户参与度预测DOI: 10.1038/s41598-025-27650-1
Diabetology & metabolic syndrome IF: 03.900Ahead of Print.No.101Impact of metformin on intervertebral disc degeneration in patients with diabetes: a prospective cohort study from the UK biobank二甲双胍对糖尿病患者椎间盘退变的影响：一项基于英国生物样本库的前瞻性队列研究DOI: 10.1186/s13098-025-02050-7
Int J Biol Macromol IF: 08.500Ahead of Print.No.102Injectable adhesive self-healing hyaluronic acid-based hydrogel with microenvironment-responsive metformin delivery and photothermal antibacterial activity for diabetic infected wound healing用于糖尿病感染伤口愈合的可注射粘附自愈透明质酸基水凝胶：具有微环境响应性二甲双胍递送和光热抗菌活性DOI: 10.1016/j.ijbiomac.2025.149560
Biosensors & bioelectronics IF: 10.500Ahead of Print.No.103A skin-interfaced sensor for noninvasive monitoring of pharmacokinetic and pharmacodynamic responses用于无创监测药代动力学和药效学反应的皮肤接口传感器DOI: 10.1016/j.bios.2025.118301
Scientific reports IF: 03.900Volume 15, Issue 1No.104The role and potential mechanism of PEST-containing nuclear protein (PCNP) in endothelial cell angiogenesis in vitroPEST结构域核蛋白（PCNP）在体外内皮细胞血管生成中的作用和潜在机制DOI: 10.1038/s41598-025-27494-9
Photodiagnosis Photodyn Ther IF: 02.600Ahead of Print.No.105Prediction model for the risk of vitreous haemorrhage after vitrectomy combined with intraocular injection for the treatment of proliferative diabetic retinopathy预测增生性糖尿病视网膜病变患者玻璃体切除联合眼内注药术后玻璃体腔出血风险的模型DOI: 10.1016/j.pdpdt.2025.105313
Experimental Eye Research IF: 02.700Ahead of Print.No.106Autophagy and Mitophagy in Diabetic Retinopathy: The Effects and Mechanism of Action on the Neurovascular Unit自噬与线粒体自噬在糖尿病视网膜病变中的作用：对视神经血管单元的影响与机制DOI: 10.1016/j.exer.2025.110802
Biochemical pharmacology IF: 05.600Ahead of Print.No.107GLP-1 receptor agonists as a strategy to target ER stress in diabetic retinopathy以GLP-1受体激动剂为策略靶向内质网应激治疗糖尿病视网膜病变DOI: 10.1016/j.bcp.2025.117623
J Int Med Res IF: 01.500Volume 53, Issue 12No.108Noninvasive assessment of metabolic syndrome-related renal injury using magnetic resonance imaging fat fraction and apparent diffusion coefficient: A cross-sectional study应用磁共振成像脂肪分数与表观扩散系数无创评估代谢综合征相关肾损伤：一项横断面研究DOI: 10.1177/03000605251399039
Nature communications IF: 15.700Volume 16, Issue 1No.109Metabolomics of saliva, serum, and urine for pathogenesis, diagnosis, and prognosis in gestational diabetes mellitus基于唾液、血清和尿液代谢组学的妊娠期糖尿病发病机制、诊断与预后研究DOI: 10.1038/s41467-025-65992-6
Brain & development IF: 01.300Ahead of Print.No.110Construction and clinical validation of a fetal brain magnetic resonance imaging-prediction model based on multimodal AI fusion algorithm基于多模态AI融合算法的胎儿脑磁共振成像预测模型的构建与临床验证DOI: 10.1016/j.braindev.2025.104492
Diabetologia IF: 10.200Ahead of Print.No.111Declining FXR expression coordinates neonatal beta cell mass development with microbial bile acid metabolism maturation in miceFXR表达下降协调新生小鼠β细胞质量发育与微生物胆汁酸代谢成熟DOI: 10.1007/s00125-025-06618-w
Diabetology & metabolic syndrome IF: 03.900Ahead of Print.No.112Sex differences in metabolic syndrome among U.S. adolescents, NHANES 1999-2020美国青少年代谢综合征的性别差异：NHANES 1999-2020DOI: 10.1186/s13098-025-02052-5
BMC public health IF: 03.600Ahead of Print.No.113Outdoor food advertising landscape along school-age children's daily commute routes in Chengdu: implications for childhood obesity prevention成都学龄儿童日常通勤路线上的户外食品广告景观：对儿童肥胖预防的启示DOI: 10.1186/s12889-025-25806-2
BMC geriatrics IF: 03.800Ahead of Print.No.114Development of a sarcopenic obesity risk prediction model for older adults based on the CHARLS database基于CHARLS数据库的老年人肌肉减少性肥胖风险预测模型构建DOI: 10.1186/s12877-025-06688-w
BMC gastroenterology IF: 02.600Ahead of Print.No.115The causal relationship between body mass index and perianal abscess: a Mendelian randomization study体重指数与肛周脓肿的因果关系：一项孟德尔随机化研究DOI: 10.1186/s12876-025-04555-x
Clin Mol Hepatol IF: 16.900Ahead of Print.No.116Normal-weight MASLD: reclassification, characteristics, and adverse liver outcomes across diverse populations正常体重MASLD：不同人群中的重新分类、特征与不良肝脏结局DOI: 10.3350/cmh.2025.0851
Scientific reports IF: 03.900Ahead of Print.No.117Effects of excess bodyweight and flexible Flatfoot on female stance-phase lower-limb biomechanics assessed by statistical non-parametric mapping超重与柔性扁平足对女性站立期下肢生物力学的影响：基于统计非参数映射的评估DOI: 10.1038/s41598-025-32023-9
Nature communications IF: 15.700Volume 16, Issue 1No.118Gut Phage Biobank: a collection of bacteriophages targeting human commensal bacteria肠道噬菌体生物库：靶向人体共生细菌的噬菌体集合DOI: 10.1038/s41467-025-61946-0
Adipocyte IF: 03.100Volume 14, Issue 1No.119CAPG enhances adipogenesis and inflammatory cytokine expression in adipocytesCAPG促进脂肪细胞分化并增强炎症细胞因子表达DOI: 10.1080/21623945.2025.2549456
The American surgeon IF: 00.900Ahead of Print.No.120Role of Bariatric Surgery in Modulating Fetuin-A and Metabolic Outcomes: A Systematic Review and Meta-Analysis减重手术在调节Fetuin-A及代谢结局中的作用：一项系统综述和荟萃分析DOI: 10.1177/00031348251407347
Biochim Biophys Acta Mol Cell Biol Lipids IF: 03.300Ahead of Print.No.121MiR-424-3p suppresses adipogenesis via HNRNPA0 targeting and p53-mediated ferroptosisMiR-424-3p通过靶向HNRNPA0和p53介导的铁死亡抑制脂肪生成DOI: 10.1016/j.bbalip.2025.159712
Fitoterapia IF: 02.600Ahead of Print.No.122Pharmacological insights on multifaceted therapeutic applications of stilbenoids: A comprehensive updates二苯乙烯类化合物多面治疗应用的药理学见解：全面更新DOI: 10.1016/j.fitote.2025.107034
Cancer letters IF: 10.100Ahead of Print.No.123High-fat diet induced ECM remodeling attenuates chemosensitivity in prostate cancer via activating Piezo1-dependent mitochondria-ER contacts高脂饮食诱导细胞外基质重塑通过激活Piezo1依赖性线粒体-内质网接触减弱前列腺癌化疗敏感性DOI: 10.1016/j.canlet.2025.218204
European journal of pharmacology IF: 04.700Ahead of Print.No.124GLP-1RA partially alleviates obesity-induced reproductive dysfunction driven by the interplay mechanisms of inflammation and metabolic dysregulation via the SIRT-associated pathwayGLP-1受体激动剂通过SIRT关联通路部分缓解由炎症与代谢失调相互作用驱动的肥胖所致生殖功能障碍DOI: 10.1016/j.ejphar.2025.178459
Brain research IF: 02.600Ahead of Print.No.125Unforgettable food memories in overweight/obese individuals-Evidence from Think/No-Think experiment超重/肥胖个体中难以忘记的食物记忆——来自想/不想范式实验的证据DOI: 10.1016/j.brainres.2025.150108
Cell metabolism IF: 30.900Ahead of Print.No.126Macrophage PD-1 regulates energy expenditure and metabolic dysfunction under immune checkpoint blockade免疫检查点阻断下巨噬细胞PD-1调控能量消耗与代谢功能障碍DOI: 10.1016/j.cmet.2025.11.009
J Nutr Health Aging IF: 04.000Ahead of Print.No.127Dietary manganese, type 2 diabetes, and cardiovascular disease: A UK Biobank cohort study and meta-analysis of over 270,000 individuals膳食锰、2型糖尿病与心血管疾病：一项基于英国生物样本库的队列研究及针对超过27万人的荟萃分析DOI: 10.1016/j.jnha.2025.100754
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Scientific reports IF: 03.900Volume 15, Issue 1No.129Activated vitamin D(3) improves the microbiota and intestinal barrier in type 2 diabetic mice via modulating AMPK activation活性维生素D3通过调控AMPK激活改善2型糖尿病小鼠的肠道菌群及屏障功能DOI: 10.1038/s41598-025-27937-3
Scientific reports IF: 03.900Volume 15, Issue 1No.130Diabetes duration, glycemic control, and risk of stroke and stroke subtypes: a nationwide prospective cohort study糖尿病病程、血糖控制与卒中及卒中亚型风险：一项全国性前瞻性队列研究DOI: 10.1038/s41598-025-27547-z
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Scientific reports IF: 03.900Ahead of Print.No.132Cirsiliol alleviates diabetic cardiomyopathy by inhibiting oxidative stress and improving energy metabolism through the PPAR-α/AMPK pathwayCir醚醇通过PPAR-α/AMPK通路抑制氧化应激和改善能量代谢缓解糖尿病心肌病DOI: 10.1038/s41598-025-32157-w
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Artificial organs IF: 02.300Ahead of Print.No.53Impact of Heart Allocation Change on Selection and Adverse Events of Bridged-To-Transplant Durable Ventricular Assist Device Recipients心脏分配政策变更对移植前桥接用耐久性心室辅助装置患者的选择及不良事件的影响DOI: 10.1111/aor.70042
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Journal of neuroendocrinology IF: 04.100Ahead of Print.No.55Human growth hormone-induced mitotic maladaptation in podocytes and implications in diabetic kidney disease生长激素诱导的足细胞有丝分裂适应不良及其在糖尿病肾病中的意义DOI: 10.1111/jne.70122
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J Genet Eng Biotechnol IF: 02.800Volume 23, Issue 4No.67Eco-friendly synthesis of silver nanoparticles from the leaf blades extract of seagrass Thalassia hemprichii: Multifunctional agents for biomedical and environmental applications利用海草Thalassia hemprichii叶片提取物生态友好合成银纳米颗粒：生物医学与环境应用的多功能制剂DOI: 10.1016/j.jgeb.2025.100600
J Genet Eng Biotechnol IF: 02.800Volume 23, Issue 4No.68Isolation and characterization of peroxidase from potato leaves Solanum tuberosum: Application in glucose diagnostic kit马铃薯叶过氧化物酶的分离鉴定及其在葡萄糖诊断试剂盒中的应用DOI: 10.1016/j.jgeb.2025.100584
J Genet Eng Biotechnol IF: 02.800Volume 23, Issue 4No.69Loss-of-function variant of SLC30A8 rs13266634 (C > T) protects against type 2 diabetes by stabilizing ZnT8: Insights from epidemiological and computational analysesSLC30A8 rs13266634（C > T）功能缺失变异体通过稳定ZnT8对2型糖尿病具有保护作用：来自流行病学和计算分析的见解DOI: 10.1016/j.jgeb.2025.100565
Surgical infections IF: 01.400Ahead of Print.No.70Multi-factorial Hyperlactatemia Due to Linezolid and Metformin Treatment in the Setting of Vitamin C and B1 Deficiency利奈唑胺与二甲双胍治疗背景下合并维生素C及B1缺乏所致多因素性高乳酸血症DOI: 10.1177/10962964251401522
Proteomics IF: 03.900Ahead of Print.No.71Advancing Understanding of the Protein Composition of Human Seminal Extracellular Vesicles推进对人类精液细胞外囊泡蛋白质组成的理解DOI: 10.1002/pmic.70088
Fam Med Community Health IF: 04.300Volume 13, Issue 4No.72Insights into diabetes remission services: perspectives from general practitioners, family physicians and multidisciplinary teams深入了解糖尿病缓解服务：全科医生、家庭医生和多学科团队的视角DOI: 10.1136/fmch-2025-003631
Am J Med Genet A IF: 01.700Ahead of Print.No.73Identification of Compound Heterozygous CYP11A1 Variants via Reanalysis of Clinical Sequencing Data通过重新分析临床测序数据鉴定CYP11A1复合杂合变异DOI: 10.1002/ajmga.70008
JCE IF: 02.600Ahead of Print.No.74Near-Zero-Fluoroscopy Ablation of Atrial Fibrillation Without ICE or Non-Fluoroscopic Tracking Systems: Findings From the SHORT LOOK Registry不使用ICE或非透视跟踪系统的近零透视心房颤动消融：SHORT LOOK注册研究结果DOI: 10.1111/jce.70225
Int J Biol Macromol IF: 08.500Ahead of Print.No.75Fabrication of ferulic acid-decorated ZnO nanoparticles in a chitosan matrix: A bioactive powder for wound management阿魏酸修饰的ZnO纳米颗粒在壳聚糖基质中的制备：一种用于伤口管理的生物活性粉末DOI: 10.1016/j.ijbiomac.2025.149640
Canadian journal of diabetes IF: 02.600Ahead of Print.No.76Optimizing patient partner engagement and integration in research: Recommendations from a qualitative study of focus groups with patient partners living with type 1 or type 2 diabetes优化研究中患者伙伴的参与和整合：来自1型或2型糖尿病患者伙伴焦点小组定性研究的建议DOI: 10.1016/j.jcjd.2025.12.002
Biochimie IF: 03.000Ahead of Print.No.77A comprehensive review on the Advanced Glycation End Products detection: From conventional to advanced approaches晚期糖基化终末产物检测方法综述：从传统到先进手段DOI: 10.1016/j.biochi.2025.12.004
Ann Allergy Asthma Immunol IF: 04.700Ahead of Print.No.78Gestational diabetes and childhood lung function at age 8-9 years in a diverse US cohort美国一项多样族裔队列研究表明：妊娠期糖尿病与8-9岁儿童肺功能下降相关DOI: 10.1016/j.anai.2025.12.006
Exp Clin Endocrinol Diabetes IF: 01.700Ahead of Print.No.79Association of fibrosis index-4 (FIB-4) with chronic vascular complications of type 2 diabetes mellitus纤维化指数-4（FIB-4）与2型糖尿病慢性血管并发症的关联DOI: 10.1055/a-2765-6480
Diabetes & metabolic syndrome IF: 03.400Ahead of Print.No.80Assessing the quality and guideline-concordance of AI-powered chatbots in nutritional management of diabetes评估AI驱动聊天机器人在糖尿病营养管理中的质量与指南一致性DOI: 10.1016/j.dsx.2025.103355
Tissue & cell IF: 02.500Ahead of Print.No.81Membrane-engineered Wharton's Jelly derived mesenchymal stem cells with anti-CD2 antibody coating modulate activated CD3(+) T-cell responses膜工程化沃顿胶来源间充质干细胞联合抗CD2抗体涂层调节活化CD3(+) T细胞应答DOI: 10.1016/j.tice.2025.103274
Journal of plant physiology IF: 04.100Ahead of Print.No.82Triumphing over hidden hunger: Redesigning rice (Oryza sativa L.) for enhanced nutraceutical grain composition utilizing multiplexed genome editing战胜隐性饥饿：利用多重基因组编辑技术改良水稻的保健谷物成分DOI: 10.1016/j.jplph.2025.154667
JMIR research protocols IF: 01.500Volume 14, Issue No.83Co-Design of a Digital Health Platform for Chronic Disease Management in Rural Settings Using a Person-Centered, Collaborative-Care Model: Protocol for a 3-Phase Mixed Methods Study采用以人为本、协作护理模式在农村环境中共同设计慢性病管理数字健康平台：一项三阶段混合方法研究方案DOI: 10.2196/77844
PloS one IF: 02.600Volume 20, Issue 12No.84Hyperglycemia and bladder cancer prognosis in a Finnish population-based cohort高血糖与芬兰人群队列中膀胱癌预后的关系DOI: 10.1371/journal.pone.0338215
Advances in physiology education IF: 01.700Ahead of Print.No.85Endometriosis: Pathophysiology and the Potential Role of Diet子宫内膜异位症：病理生理学与饮食的潜在作用DOI: 10.1152/advan.00198.2025
Pancreas IF: 01.700Ahead of Print.No.86Internet-delivered Cognitive-behavioral Intervention for Pain in Pediatric Acute Recurrent and Chronic Pancreatitis: A Multicenter Randomized Controlled Trial针对儿童急性复发性及慢性胰腺炎疼痛的互联网提供认知行为干预：一项多中心随机对照试验DOI: 10.1097/MPA.0000000000002558
Cell reports IF: 06.900Ahead of Print.No.87VIP interneuron activity during sleep conveys the cortical infraslow oscillation睡眠中VIP中间神经元的活动传导皮层超慢振荡DOI: 10.1016/j.celrep.2025.116669
The Journal of frailty & aging IF: 03.300Ahead of Print.No.88Association between diabetes and frailty, and the moderating role of sex in that association in older adults of the ELSA-Brasil study老年糖尿病与衰弱的关系及性别在其中的调节作用：ELSA-Brasil研究DOI: 10.1016/j.tjfa.2025.100115
Clin J Am Soc Nephrol IF: 07.100Ahead of Print.No.89Efficacy, Mechanisms and Safety of Sodium-Glucose Cotransporter-2 Inhibitors in Kidney Transplant Recipients: A Randomized, Double-Blind, Placebo-Controlled Trial钠-葡萄糖协同转运蛋白2抑制剂在肾移植受者中的有效性、机制与安全性：一项随机、双盲、安慰剂对照试验DOI: 10.2215/CJN.0000000951
Clin J Am Soc Nephrol IF: 07.100Ahead of Print.No.90Comparison of Low eGFR Prevalence and Prediction for Mortality Using 2009 and 2021 CKD-EPI Equations in Mexican Adults使用2009与2021年CKD-EPI方程比较墨西哥成人中低eGFR患病率及其对死亡率的预测价值DOI: 10.2215/CJN.0000000933
PloS one IF: 02.600Volume 20, Issue 12No.91Mapping the microRNA-mediated crosstalk between insulin resistance and Alzheimer's disease: A computational genomic insight绘制胰岛素抵抗与阿尔茨海默病之间由microRNA介导的交互作用图谱：一项计算基因组学视角DOI: 10.1371/journal.pone.0329056
Cell reports IF: 06.900Ahead of Print.No.92DEC1 regulates human β cell functional maturation and circadian rhythmDEC1调控人类β细胞功能成熟与昼夜节律DOI: 10.1016/j.celrep.2025.116666
Kidney360 IF: 03.000Ahead of Print.No.93Emerging Therapies in Autosomal Dominant Polycystic Kidney Disease常染色体显性多囊肾病的新兴疗法DOI: 10.34067/KID.0000001109
Appl Physiol Nutr Metab IF: 02.000Ahead of Print.No.94Bottle to Body: How Multivitamin/Mineral Supplements Shape Canadian Nutrient Intake从补充剂到身体：复合维生素/矿物质补充剂如何影响加拿大人的营养摄入DOI: 10.1139/apnm-2025-0305
Am J Physiol Endocrinol Metab IF: 03.100Ahead of Print.No.95RYGB Induces Vagal Sensory Neuropathy Characterized by Altered GLP1R Expression and Enhanced Exendin-4 Responsiveness in Male Mice胃旁路术诱导迷走神经感觉神经病变，其特征为GLP1R表达改变和Exendin-4反应性增强DOI: 10.1152/ajpendo.00452.2025
AIDS care IF: 01.200Ahead of Print.No.96Association between diet quality, physical activity and anthropometric status of people living with HIV in Cape Town开普敦HIV感染者的饮食质量、体力活动与人体测量学状况之间的关联DOI: 10.1080/09540121.2025.2586244
PloS one IF: 02.600Volume 20, Issue 12No.97Public knowledge and awareness of obstructive sleep apnea in Saudi Arabia: A population-based study of over 16,000 adults沙特阿拉伯公众对阻塞性睡眠呼吸暂停的知识与认知：一项基于超过1.6万名成年人的群体研究DOI: 10.1371/journal.pone.0337822
Clin J Am Soc Nephrol IF: 07.100Ahead of Print.No.98Sodium-Glucose Cotransporter-2 Inhibitors and Ketoacid Diets for Diabetic Kidney Disease钠-葡萄糖协同转运蛋白-2抑制剂与酮酸饮食治疗糖尿病肾病DOI: 10.2215/CJN.0000000958
Kidney360 IF: 03.000Ahead of Print.No.99Targeting αvβ8 Integrin with Monoclonal Antibody MEDI8367 Prevents Fibrosis in Preclinical Models of CKD单克隆抗体MEDI8367靶向αvβ8整合素可在慢性肾病临床前模型中预防纤维化DOI: 10.34067/KID.0000001006
Journal of medicinal chemistry IF: 06.800Ahead of Print.No.100Design, Optimization, and Biological Evaluation of First-in-Class Triple Inhibitors of SGLT1, SGLT2, and DPP4 for Type 2 Diabetes Mellitus针对2型糖尿病的SGLT1、SGLT2与DPP4三重抑制剂的研发、优化与生物学评价DOI: 10.1021/acs.jmedchem.5c02225
PloS one IF: 02.600Volume 20, Issue 12No.101Shift from visceral to subcutaneous adipose tissue in Cyp17a1-knockout rats prevents the progression of metabolic syndromeCyp17a1基因敲除大鼠脂肪从内脏向皮下转移阻止代谢综合征进展DOI: 10.1371/journal.pone.0311478
Fundam Clin Pharmacol IF: 02.500Volume 40, Issue 1No.102Gabapentinoids and Neuropathic Pain: Evaluation of the Quality of Randomised Controlled Trials: An Umbrella Review加巴喷丁与神经病理性疼痛：随机对照试验质量的评估：一项伞状评价DOI: 10.1111/fcp.70052
J Racial Ethn Health Disparities IF: 02.400Ahead of Print.No.103A Scoping Review of Racial Identity, Racial Socialization, and Africentric Worldview in the Context of Obesity in Black Adolescent Females黑人少女肥胖背景下的种族认同、种族社会化与非洲中心世界观：一项范围综述DOI: 10.1007/s40615-025-02678-1
Matern Child Health J IF: 01.700Ahead of Print.No.104Low Calcium Intake in High-Risk Pregnant Women: What are the Associated Factors?高危孕妇钙摄入不足：相关因素有哪些？DOI: 10.1007/s10995-025-04200-9
Hernia IF: 02.400Volume 30, Issue 1No.105Enhancing prediction of incisional hernia in liver transplant patients: performance assessment and stepwise revision of a prognostic model提升肝移植患者切口疝的预测能力：一项预后模型的性能评估与逐步修订DOI: 10.1007/s10029-025-03508-3
West J Nurs Res IF: 01.700Ahead of Print.No.106Factors Related to Binge Eating in Korean American Women韩国裔美国女性暴食相关因素研究DOI: 10.1177/01939459251391989
Endocrine connections IF: 02.800Ahead of Print.No.107Short-term changes in des-acyl ghrelin following bariatric surgery减重手术后脱酰基生长激素释放肽的短期变化DOI: 10.1530/EC-25-0325
Vopr Kurortol Fizioter Lech Fiz KultVolume 102, Issue 5. Vyp. 2No.108[Effective management of biological age and quality of life in patients based on the integrated use of pathogenetically focused medical rehabilitation methods]基于病理生理学导向医疗康复方法整合应用有效管理患者生物学年龄与生活质量DOI: 10.17116/kurort202510205281
Vopr Kurortol Fizioter Lech Fiz KultVolume 102, Issue 5. Vyp. 2No.109[The informative value of methods for diagnosing aging and the development of prognostic criteria for the effectiveness of complex physiotherapy for managing active longevity]诊断衰老方法的信息价值及制定综合物理疗法管理积极长寿疗效的预后标准DOI: 10.17116/kurort202510205235
Cancer prevention research IF: 02.600Ahead of Print.No.110Uncovering the Red Flags: A Cross-Sectional Retrospective Case-Control Study on Predictors of Early Onset Colorectal Cancer in a Multi-State Community Health System揭示危险信号：一项多州社区医疗系统中早发性结直肠癌预测因素的横断面回顾性病例对照研究DOI: 10.1158/1940-6207.CAPR-25-0232
Indian Journal of Ophthalmology IF: 01.800Ahead of Print.No.111Ocular warnings of a silent killer: A case series on intracranial aneurysms无声杀手的眼部预警：颅内动脉瘤病例系列研究DOI: 10.4103/IJO.IJO_1543_25
J Endocrinol Invest IF: 03.500Ahead of Print.No.112Circulating 1,5-anhydroglucitol levels combined with pre-pregnancy BMI is a simple predictive marker of future glucose intolerance in women with gestational diabetes循环1,5-脱水葡萄糖醇水平联合孕前BMI是妊娠糖尿病女性未来葡萄糖不耐受的简单预测标志物DOI: 10.1007/s40618-025-02768-1
Diabetologia IF: 10.200Ahead of Print.No.113Impact of normoglycaemia and prediabetes definitions on the estimated benefits of regression from prediabetes to normoglycaemia for type 2 diabetes risk. Reply to Choi W [Letter]基于正常血糖与糖尿病前期不同定义评估从糖尿病前期回归正常血糖状态对降低2型糖尿病风险的估计影响——答Choi W来信DOI: 10.1007/s00125-025-06641-x
European journal of pediatrics IF: 02.600Volume 185, Issue 1No.114About potential value and limitations of continuous glucose monitoring in DKA连续葡萄糖监测在糖尿病酮症酸中毒中的潜在价值与局限性探讨DOI: 10.1007/s00431-025-06684-7
Indian journal of pediatrics IF: 02.000Ahead of Print.No.115Pattern and Persistence of Islet Autoantibodies and their Immunogenetic Association among Type 1 Diabetes Patients from North India北印度1型糖尿病患者胰岛自身抗体模式、持续性及其免疫遗传学关联DOI: 10.1007/s12098-025-05882-3
Obesity surgery IF: 03.100Ahead of Print.No.116Correction: Metabolic Surgery for Obese Type 2 Diabetes: Korean Multicenter Cohort Study代谢外科手术治疗肥胖型2型糖尿病：韩国多中心队列研究DOI: 10.1007/s11695-025-08413-3
Hernia IF: 02.400Volume 30, Issue 1No.117Factors associated with venous thromboembolism in retromuscular ventral hernia repair - an abdominal core health quality collaborative analysis腹后间隙腹疝修补术中静脉血栓栓塞的相关因素分析——基于腹壁核心健康质量协作组数据库的研究DOI: 10.1007/s10029-025-03530-5
HNO IF: 01.300Ahead of Print.No.118[Diagnosis and management of necrotizing otitis externa]坏死性外耳道炎的诊断与管理DOI: 10.1007/s00106-025-01690-5
Diabetes IF: 07.500Ahead of Print.No.119miR-494 Deletion Improves Glucose Metabolism Independently of Obesity in MicemiR-494缺失独立于肥胖改善小鼠葡萄糖代谢DOI: 10.2337/db25-0355
Endocrine connections IF: 02.800Volume 14, Issue 12No.120Diagnostic accuracy of the triptorelin stimulation test for central precocious puberty in girls曲普瑞林刺激试验对女孩中枢性性早熟的诊断准确性DOI: 10.1530/EC-25-0642
Nephrol Dial Transplant IF: 05.600Ahead of Print.No.121Fasting urine osmolality and risk of kidney disease progression in patients with type 2 diabetes空腹尿渗透压与2型糖尿病患者肾脏疾病进展风险的关系DOI: 10.1093/ndt/gfaf264
Biomaterials science IF: 05.700Ahead of Print.No.122Bioresorbable-bioactive auxetic "personalised" phalanx with a CT-guided AI-driven model towards in vivo prediction of bone regeneration生物可吸收-生物活性拉胀结构“个性化”指骨：一种基于CT引导和AI驱动的模型，用于体内骨再生预测DOI: 10.1039/d5bm01337b
Health promotion international IF: 02.400Volume 40, Issue 6No.123An exploration of cultural grounding in Indigenous health promotion: perspectives from First Nations communities in Canada探索土著健康促进中的文化根基：来自加拿大原住民社区的视角DOI: 10.1093/heapro/daaf211
MS. Me?decine sciences IF: 00.400Volume 41, Issue 11No.124[Cell therapy of diabetes in France: from islet transplantation to future perspectives]法国糖尿病细胞疗法：从胰岛移植到未来展望DOI: 10.1051/medsci/2025161
J Pediatr Gastroenterol Nutr IF: 02.600Ahead of Print.No.125Vibration-controlled transient elastography in pediatric metabolic dysfunction-associated steatotic liver disease振动控制瞬时弹性成像技术在儿科代谢功能障碍相关脂肪性肝病中的应用DOI: 10.1002/jpn3.70284
European thyroid journal IF: 04.300Ahead of Print.No.126Selenium supplementation in individuals with newly diagnosed Graves' hyperthyroidism: A double-blind, multi-centre RCT新诊断Graves甲状腺功能亢进症患者的硒补充：一项双盲、多中心随机对照试验DOI: 10.1530/ETJ-25-0264
Acta Bioeng Biomech IF: 00.800Volume 27, Issue 3No.127A novel data mining approach for early diagnosis of gestational diabetes mellitus (GDM) in pregnancy via machine learning methods and CNN通过机器学习方法与CNN实现妊娠期糖尿病（GDM）早期诊断的一种新型数据挖掘方法DOI: 10.37190/abb/209528
Monaldi Arch Chest Dis IF: 01.100Ahead of Print.No.128Coronary plaques and pericardial fat volume assessment in patients with metabolic syndrome being evaluated for suspected coronary artery disease代谢综合征疑诊冠心病患者冠状动脉斑块特征与心包脂肪体积的评估DOI: 10.4081/monaldi.2025.3390
Am J Gastroenterol IF: 07.600Ahead of Print.No.129Glucagon-like peptide-1 receptor agonist treatment and risk of esophageal cancer胰高血糖素样肽-1受体激动剂治疗与食管癌风险DOI: 10.14309/ajg.0000000000003885
Endocrine connections IF: 02.800Ahead of Print.No.130Changes in Fibroblast Growth Factor 21 Levels Associated with Alcohol Consumption and Smoking Cessation与饮酒和戒烟相关的成纤维细胞生长因子21水平变化DOI: 10.1530/EC-25-0713
Daru IF: 02.100Volume 34, Issue 1No.131Resveratrol and caffeic acid attenuate diet-induced obesity by inhibiting the SREBP-1/ACLY lipogenic axis in adipose tissue of rats白藜芦醇与咖啡酸通过抑制脂肪组织中的SREBP-1/ACLY脂生成轴来减轻大鼠饮食诱导的肥胖DOI: 10.1007/s40199-025-00582-x
Am J Gastroenterol IF: 07.600Ahead of Print.No.132Poor Sensitivity of the Fatty Liver Index Among Lean Individuals脂肪肝指数在瘦人中的敏感性较差DOI: 10.14309/ajg.0000000000003883
Assist Inferm Ric IF: 00.900Volume 44, Issue 4No.133[Obesity as a chronic disease: the key role of new therapies]肥胖作为慢性疾病：新疗法的关键作用DOI: 10.1702/4616.46253
Pregnancy Hypertension IF: 02.900Volume 43, Issue No.134The impact of maternal chronic hypertension in pregnancy on offspring long-term respiratory morbidity妊娠期母亲慢性高血压对后代长期呼吸系统发病率的影响DOI: 10.1016/j.preghy.2025.101405
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.135P021 A case of radiation-induced haemorrhagic bullous lichen sclerosus of the breast一例乳腺癌放疗后诱发的出血性大疱性硬化性苔藓病例DOI: 10.1093/bjd/ljaf085.049
Frontiers in pharmacology IF: 04.800Volume 16, Issue No.136Efficacy and safety of Centella asiatica (L.) Urb. [Apiaceae] as a dietary supplement for glycemic control and lipid regulation in patients with type 2 diabetes: a randomized controlled trial in Thailand积雪草（Centella asiatica (L.) Urb. [Apiaceae]）作为膳食补充剂用于2型糖尿病患者血糖控制与血脂调节的有效性与安全性：一项泰国随机对照试验DOI: 10.3389/fphar.2025.1680647
Rom J Morphol Embryol IF: 01.500Volume 66, Issue 3No.137The influence of diabetes mellitus on blood vessels' amounts and immune status in case of breast cancer糖尿病对乳腺癌患者血管数量及免疫状态的影响DOI: 10.47162/RJME.66.3.12
Plant Physiol Biochem IF: 05.700Volume 229, Issue Pt CNo.138Encapsulated GABA coatings as a postharvest strategy to enhance mango chilling tolerance包封GABA涂层作为增强芒果采后耐冷性的策略DOI: 10.1016/j.plaphy.2025.110644
Diabetes Metab Syndr Obes IF: 03.000Volume 18, Issue No.139Quality of Life and Diabetic Complications Among Type 2 Diabetes Patients Across Healthcare Levels in Bandung, Indonesia印尼万隆市不同医疗层级2型糖尿病患者的生活质量与糖尿病并发症DOI: 10.2147/DMSO.S549279
Biology open IF: 01.700Ahead of Print.No.140miR-302 regulates pancreatic progenitor pool and pancreatic sizemiR-302调控胰腺祖细胞池与胰腺大小DOI: 10.1242/bio.062353
Transplant international IF: 03.000Volume 38, Issue No.141Death and Graft Loss in Simultaneous Pancreas-Kidney Recipients by Donor-Recipient Cytomegalovirus Serostatus in the United States基于供受者巨细胞病毒血清状态的美国同期胰腺-肾移植受者死亡与移植物丢失分析DOI: 10.3389/ti.2025.15653
Frontiers in health services IF: 02.700Volume 5, Issue No.142The DIAMONDS intervention for type 2 diabetes for people with severe mental illness: findings from a single-group feasibility study针对严重精神疾病患者的2型糖尿病DIAMONDS干预措施：单组可行性研究结果DOI: 10.3389/frhs.2025.1688787
J Biostat Biom ApplVolume 9, Issue 1No.143Factors Affecting Time to Return to a Normal Level of Hba1c Among Diabetes Mellitus Patients at Hawassa University Comprehensive Specialized Hospital, Hawassa, Ethiopia影响糖尿病患者糖化血红蛋白恢复至正常水平时间的因素https://pubmed.ncbi.nlm.nih.gov/41384241
Curēus IF: 01.300Volume 17, Issue 11No.144Evaluation of the Analytical Performance of a High-Precision Immunoassay for the Creatine Kinase-MB Isoenzyme高精度肌酸激酶-MB同工酶免疫测定方法的分析性能评估DOI: 10.7759/cureus.96457
Curēus IF: 01.300Volume 17, Issue 11No.145Unlocking the Potential of Negative Pressure Wound Therapy in Diabetic Foot Ulcers: A Systematic Review and Meta-Analysis解锁负压伤口疗法在糖尿病足溃疡中的潜力：一项系统综述与荟萃分析DOI: 10.7759/cureus.96474
Frontiers in oral health IF: 03.100Volume 6, Issue No.146Dental implant failure and retrieval techniques; a scoping review种植牙失败与取出技术：一项范围性综述DOI: 10.3389/froh.2025.1667808
JCEM case reportsVolume 4, Issue 1No.147Central Precocious Puberty and Hypothalamic Teratoma中枢性性早熟与下丘脑畸胎瘤DOI: 10.1210/jcemcr/luaf275
Caspian J Intern Med IF: 01.000Volume 16, Issue 4No.148Relationship between thyroid nodule, prolactin, and thyroid peroxidase antibody levels: A case-control study甲状腺结节、泌乳素与甲状腺过氧化物酶抗体水平的关系：一项病例对照研究DOI: 10.22088/cjim.16.4.712
bioRxivVolume 2025, Issue No.149EXPERIMENTAL CHARACTERIZATION OF BALLOON ANGIOPLASTY IN HUMAN FEMOROPOPLITEAL ARTERIES WITH DIFFERENT CALCIUM BURDENS不同钙负荷人体股腘动脉中球囊血管成形术的实验特征DOI: 10.1101/2025.11.27.691029
Clinical case reports IF: 00.600Volume 13, Issue 12No.150Myiasis of the Mastoid Cavity: Case Report乳突腔蝇蛆病：病例报告DOI: 10.1002/ccr3.71671
NeuroprotectionVolume 3, Issue 1No.151Decoding the role of large heat shock proteins in the progression of neuroinflammation-mediated neurodegenerative disorders解码大热休克蛋白在神经炎症介导的神经退行性疾病进展中的作用DOI: 10.1002/nep3.68
Skin appendage disorders IF: 01.300Ahead of Print.No.152Retrospective Analysis of Nail Changes and Comorbidities in Darier Disease达里埃病甲改变与合并症的回顾性分析DOI: 10.1159/000549631
Frontiers in nutrition IF: 05.100Volume 12, Issue No.153Consumption of commercial and traditional sugar-sweetened beverages among adolescents in Pakistan: evidence from a national survey巴基斯坦青少年商业和传统含糖饮料消费情况：基于全国调查的证据DOI: 10.3389/fnut.2025.1679917
Rev Panam Salud Publica IF: 02.200Volume 49, Issue No.154[Factors associated with cardiometabolic disease screening in older adults in the Peruvian AmazonFatores associados ao rastreamento de doenças cardiometabólicas em pessoas idosas da Amazônia peruana]秘鲁亚马逊地区老年人心脏代谢疾病筛查的相关因素分析DOI: 10.26633/RPSP.2025.118
Rev Panam Salud Publica IF: 02.200Volume 49, Issue No.155[Implementation of hypertension and diabetes care pathways in two regions of the Brazilian NortheastImplementación de las líneas de cuidado para la hipertensión y la diabetes en dos regiones del nordeste brasileño]巴西东北部两个地区高血压与糖尿病护理路径的实施DOI: 10.26633/RPSP.2025.117
Rev Panam Salud Publica IF: 02.200Volume 49, Issue No.156[Nursing consultations in primary health care in Brazil: distribution and productivity in the management of chronic noncommunicable diseasesConsultas atendidas por personal de enfermería en la atención primaria de salud en Brasil: distribución y productividad en las consultas relativas a enfermedades crónicas no transmisibles]巴西初级卫生保健中的护理咨询：慢性非传染性疾病管理的分布与生产率DOI: 10.26633/RPSP.2025.115
Sage open agingVolume 11, Issue No.157Factors Associated With Subjective Wellbeing in Community-Dwelling Homebound Older Adults With Diabetes in the US美国居家不便老年糖尿病患者主观幸福感的相关因素研究DOI: 10.1177/30495334251404290
Frontiers in neurology IF: 02.800Volume 16, Issue No.158SAFE-CGRP study: multicenter retrospective evaluation of the safety of CGRP pathway-targeting monoclonal antibodies in migraine with relevant comorbidities or conditions excluded from trialsSAFE-CGRP研究：针对CGRP通路单克隆抗体在具有临床试验排除的相关合并症偏头痛患者中的多中心回顾性安全性评价DOI: 10.3389/fneur.2025.1703876
J Diabetes Sci Technol IF: 03.700Ahead of Print.No.159Creation and Evaluation of a Research Participant Portal for the University of Chicago Monogenic Diabetes Registry创建和评估芝加哥大学单基因糖尿病注册研究参与者门户DOI: 10.1177/19322968251399666
Rom J Morphol Embryol IF: 01.500Volume 66, Issue 3No.160Leveraging artificial intelligence for cardiovascular risk: a primary care perspective基于人工智能的心血管风险评估：来自初级医疗的视角DOI: 10.47162/RJME.66.3.13
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.161P082 The WHO-5 wellbeing measure as an assessment tool in inflammatory skin diseasesWHO-5幸福感量表作为炎症性皮肤病的评估工具DOI: 10.1093/bjd/ljaf085.110
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.162P105 Lebrikizumab improves quality of life and wellbeing of patients with moderate-to-severe atopic dermatitis inadequately controlled with or ineligible for ciclosporin: German extension results (week 76) of the ADvantage studyLebrikizumab改善对环孢素控制不佳或不适合使用的中重度特应性皮炎患者的生活质量及幸福感：ADvantage研究德国延长期（第76周）结果DOI: 10.1093/bjd/ljaf085.133
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.163BH20 A multicentre analysis of the adequacy of alopecia horizontal biopsy samples over 10 years一项十年期多中心分析：脱发水平活检样本的充分性DOI: 10.1093/bjd/ljaf085.241
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.164O05 A retrospective review of cases of psoriasis requiring discontinuation of biologic therapy from 2007 to 2024 in a multisite NHS trust一项对2007年至2024年间多中心NHS信托银屑病需停用生物制剂病例的回顾性研究DOI: 10.1093/bjd/ljaf085.020
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.165BG12 Carotenaemia: a persistent orange hueBG12 胡萝卜素血症：一种持续性的橙色调DOI: 10.1093/bjd/ljaf085.358
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.166CPC12 An unusual case of paraneoplastic sarcoid presenting as dactylitis病例报告12：表现为指趾炎的副肿瘤性结节病一例DOI: 10.1093/bjd/ljaf085.012
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.167BH13 Itchy feet: skin and nail conditions in the podiatrists' clinic足部瘙痒：足病诊所中的皮肤与指甲问题DOI: 10.1093/bjd/ljaf085.234
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.168PA43 An infrequently diagnosed cause of pruritusPA43 一个罕见诊断的瘙痒病因DOI: 10.1093/bjd/ljaf085.402
The annals of pharmacotherapy IF: 02.300Ahead of Print.No.169Vildagliptin-Associated Acquired Hemophilia A维格列汀相关的获得性血友病ADOI: 10.1177/10600280251403095
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.170P110 Low prevalence of liver fibrosis in patients with atopic dermatitis on methotrexate甲氨蝶呤治疗的特应性皮炎患者肝纤维化患病率较低DOI: 10.1093/bjd/ljaf085.138
Plastic surgery IF: 00.600Ahead of Print.No.171Effect of Body Contouring Procedures on Changes in Long-Term Weight and Metabolic Health身体轮廓整形手术对长期体重及代谢健康变化的影响DOI: 10.1177/22925503251400374
Health science reports IF: 02.100Volume 8, Issue 12No.172Comparative Effectiveness of Insulin Versus Oral Hypoglycemic Agents in Diabetic Patients With Acute Stroke: A Retrospective Cross-Sectional Analysis of Treatment Outcomes and Influencing Factors胰岛素与口服降糖药在伴有急性卒中的糖尿病患者中的疗效比较：治疗结局及影响因素的回顾性横断面分析DOI: 10.1002/hsr2.71598
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.173SG02 Transdermal testosterone improves lower-extremity ulceration in a young man with newly diagnosed Klinefelter syndrome (47 XXY)经皮睾酮改善新诊断47XXY克氏综合征年轻男性下肢溃疡DOI: 10.1093/bjd/ljaf085.511
Caspian J Intern Med IF: 01.000Volume 16, Issue 4No.174Association of celiac disease with type 1 diabetes: A cross-sectional analysis in 2022乳糜泻与1型糖尿病的关联：一项2022年的横断面分析DOI: 10.22088/cjim.16.4.797
Pediatric diabetes IF: 05.600Volume 2025, Issue No.175Exploring the Influence of a Diabetes Specialty Outpatient Clinic on Adolescents With Type 1 Diabetes in Barbados: A Qualitative Study探索巴巴多斯糖尿病专科门诊对1型糖尿病青少年的影响：一项定性研究DOI: 10.1155/pedi/5454172
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.176CD02 Colophonium derivatives as key allergens in diabetes technology-associated allergic contact dermatitis: a hidden concern in the British Society for Cutaneous Allergy standard seriesCD02：松香衍生物是糖尿病技术相关过敏性接触性皮炎的关键过敏原——英国皮肤过敏学会标准系列中的一个隐忧DOI: 10.1093/bjd/ljaf085.271
Frontiers in physiology IF: 03.400Volume 16, Issue No.177Impact of vascular density on pancreatic islet viability: a computational study血管密度对胰岛细胞活力的影响：一项计算研究DOI: 10.3389/fphys.2025.1707026
RSC advances IF: 04.600Volume 15, Issue 57No.178Nanoliposome-based drug delivery systems for the treatment of diabetes mellitus: a review糖尿病治疗：纳米脂质体药物递送系统综述DOI: 10.1039/d5ra07152f
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.179Scars of oxidative stress: protein carbonylation and beta cell dysfunction in diabetes氧化应激的疤痕：蛋白羰基化与糖尿病中的β细胞功能障碍DOI: 10.3389/fendo.2025.1722623
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.180The frequency of polycystic ovary syndrome in women with prediabetes compared with normoglycemic women与血糖正常女性相比，糖尿病前期女性中多囊卵巢综合征的发生率DOI: 10.3389/fendo.2025.1722978
Veterinary medicine and science IF: 01.700Volume 12, Issue 1No.181Effect of Feeding Cottonseed Meal With or Without NSP Enzymes on Growth Performance, Blood Biochemistry, Growth-Related Gene Expression, Intestinal Health and Economic Efficiency in Broilers饲喂添加或不添加NSP酶的棉籽粕对肉鸡生长性能、血液生化、生长相关基因表达、肠道健康和经济效率的影响DOI: 10.1002/vms3.70723
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.182CD19 Contact allergy to colophonium and Abitol in a continuous glucose monitor securing tapeCD19 对连续血糖监测仪固定胶带中松香和松香醇的接触性过敏DOI: 10.1093/bjd/ljaf085.288
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.183P024 Anakinra for recalcitrant pyoderma gangrenosum with Achilles tendon exposureP024 阿那白滞素治疗伴跟腱暴露的顽固性坏疽性脓皮病DOI: 10.1093/bjd/ljaf085.052
Caspian J Intern Med IF: 01.000Volume 16, Issue 4No.184Association between triglyceride-glucose index and nephrolithiasis among the elderly in Amirkola: A cross-sectional population-based studyAmirkola地区老年人群甘油三酯-葡萄糖指数与肾结石的关联：一项基于人群的横断面研究DOI: 10.22088/cjim.16.4.741
J Clin Endocrinol Metab IF: 05.100Ahead of Print.No.185Visceral adipose tissue and liver fat on 17-beta estradiol-dominant gender-affirming hormone therapy: A US-based cohort美国队列研究：17β-雌二醇主导的性别肯定激素治疗对内脏脂肪组织及肝脏脂肪的影响DOI: 10.1210/clinem/dgaf665
BioFactors IF: 05.000Volume 51, Issue 6No.186Extracellular Vesicles Released From Prostate Cancer Cells Confer Pro-Tumor Properties to Adipocytes by Stimulating Lipolysis前列腺癌细胞释放的胞外囊泡通过刺激脂解作用赋予脂肪细胞促肿瘤特性DOI: 10.1002/biof.70067
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.187PA41 Treating severe nodulocystic acne with isotretinoin in children with cystic fibrosis使用异维A酸治疗囊性纤维化儿童的严重结节囊肿性痤疮DOI: 10.1093/bjd/ljaf085.400
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.188P070 Effect of insulin resistance on treatment response in moderate-to-severe psoriasis: a retrospective study胰岛素抵抗对中重度银屑病治疗效果的影响：一项回顾性研究DOI: 10.1093/bjd/ljaf085.098
Journal of diabetes research IF: 03.400Volume 2025, Issue No.189Longitudinal Study on the Progression of Diabetes Mellitus Patients at Jimma University Specialized Hospital, Ethiopia埃塞俄比亚Jimma大学专科医院糖尿病患者的纵向研究DOI: 10.1155/jdr/7035393
Caspian J Intern Med IF: 01.000Volume 16, Issue 4No.190Carotid sonographic features in Takayasu's arteritis: A case-control study高安动脉炎的颈动脉超声特征：一项病例对照研究DOI: 10.22088/cjim.16.4.747
NeuroprotectionVolume 3, Issue 2No.191Beta cells to brain cells: The pivotal role of insulin and glucose metabolism in Alzheimer's disease从β细胞到脑细胞：胰岛素与葡萄糖代谢在阿尔茨海默病中的关键作用DOI: 10.1002/nep3.70008
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.192BC06 Investigating the role of metformin in melasma management: a review探究二甲双胍在黄褐斑管理中的作用：一篇综述DOI: 10.1093/bjd/ljaf085.219
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.193P111 A multicentre service evaluation highlighting the variable off-label prescribing practice of spironolactone in the management of hidradenitis suppurativa: the need for evidence-based guidelines一项多中心服务评估揭示螺内酯治疗化脓性汗腺炎的标签外处方实践差异显著：凸显循证指南的必要性DOI: 10.1093/bjd/ljaf085.139
Curēus IF: 01.300Volume 17, Issue 11No.194Initial Institutional Experience and Workflow of Biology-Guided Radiotherapy (BgRT) for a Patient With Non-small Cell Lung Cancer针对非小细胞肺癌患者的生物引导放疗（BgRT）：机构初步经验与工作流程DOI: 10.7759/cureus.96513
Frontiers in digital health IF: 03.800Volume 7, Issue No.195Dissecting the difference between positive and negative brain health sentiment using X data剖析X平台数据中脑健康正负面情绪差异DOI: 10.3389/fdgth.2025.1648671
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.196PS11 Successful treatment of chronic pruritus and secondary ulceration with aprepitant阿瑞匹坦成功治疗慢性瘙痒和继发性溃疡DOI: 10.1093/bjd/ljaf085.509
Eur J Transl Myol IF: 01.800Ahead of Print.No.197Analysis of the Effects of Dapagliflozin on Cardiac Myocyte Injury Markers and Left Ventricular Diastolic Function in Heart Failure Patients with Preserved Ejection Fraction after PCI达格列净对PCI术后射血分数保留心力衰竭患者心肌损伤标志物及左心室舒张功能的影响分析DOI: 10.4081/ejtm.2025.14272
Clinical ophthalmology IF: 02.200Volume 19, Issue No.198Structural and Functional Outcomes of Optic Pathway Compression in Pituitary Adenoma: A Prospective Pilot OCT Study垂体腺瘤视通路压迫的结构与功能转归：一项前瞻性OCT试点研究DOI: 10.2147/OPTH.S556193
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.199P121 Treatment with semaglutide improves the systemic inflammatory burden associated with hidradenitis suppurativa司美格鲁肽治疗改善化脓性汗腺炎相关的全身炎症负担DOI: 10.1093/bjd/ljaf085.149
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.200BH10 Nailing the diagnosis从指甲入手明确诊断DOI: 10.1093/bjd/ljaf085.231
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.201DP11 A case of Langerhans cell histiocytosis masquerading as lymphocytic hypophysitis and panhypopituitarism伪装成淋巴细胞性垂体炎和全垂体功能减退症的朗格汉斯细胞组织细胞增生症一例DOI: 10.1093/bjd/ljaf085.334
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.202BI34 Scleromyxoedema in pregnancy: a rare and complex case妊娠合并硬化性粘液水肿：一例罕见复杂病例DOI: 10.1093/bjd/ljaf085.443
Curēus IF: 01.300Volume 17, Issue 11No.203Sodium-Glucose Cotransporter-2 (SGLT2) Inhibitors and Risk of Heart Failure Hospitalization in Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials钠-葡萄糖协同转运蛋白-2抑制剂与2型糖尿病患者心衰住院风险：一项随机对照试验的系统回顾与荟萃分析DOI: 10.7759/cureus.96456
bioRxivVolume 2025, Issue No.204Disease-associated mutations in the STAT5B SH2 domain reprogram hepatic cholesterol and lipid metabolism疾病相关的STAT5B SH2结构域突变重编程肝脏胆固醇和脂质代谢DOI: 10.1101/2025.11.27.691004
In silico pharmacologyVolume 14, Issue 1No.205In vitro and computational evaluation of the erectogenic and anti-diabetic potential of ethanol extract of Hymenodictyon pachyantha stem barkHymenodictyon pachyantha茎皮乙醇提取物在体外和计算层面的勃起及抗糖尿病潜力评估DOI: 10.1007/s40203-025-00510-6
Curēus IF: 01.300Volume 17, Issue 11No.206Unexpected Electroencephalogram Activity in a Brain-Dead Organ Donor: A Case Report一例脑死亡器官捐献者中的意外脑电图活动DOI: 10.7759/cureus.96488
Curēus IF: 01.300Volume 17, Issue 11No.207Determinants of Hypertension Among Transport Workers in Ibadan, Nigeria: A Structural Equation Modeling Approach尼日利亚伊巴丹市运输工人高血压的影响因素：一项结构方程模型方法研究DOI: 10.7759/cureus.96458
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.208Vitamin D supplementation and its impact on leptin and interleukin-6 in women following religious intermittent fasting: a controlled study维生素D补充对遵循宗教间歇性禁食女性瘦素和白介素-6的影响：一项对照研究DOI: 10.3389/fendo.2025.1700844
Caspian J Intern Med IF: 01.000Volume 16, Issue 4No.209Association between osteoporosis and symptomatic knee osteoarthritis in postmenopausal women: A case-control study绝经后女性骨质疏松与症状性膝骨关节炎的关联：一项病例对照研究DOI: 10.22088/cjim.16.4.686
bioRxivVolume 2025, Issue No.210Hepatocyte MLKL Drives Obesity-Driven Hepatocellular Carcinoma Progression via Mitochondrial Dysfunction Independent of Necroptosis in MASLD肝细胞MLKL通过不依赖坏死性凋亡的线粒体功能障碍驱动肥胖相关的代谢功能障碍相关脂肪性肝病性肝细胞癌进展DOI: 10.1101/2025.11.26.690789
Frontiers in pediatrics IF: 02.000Volume 13, Issue No.211Influence of gestational history on neural tube defects and Eisenmenger syndrome: associations with intellectual disability and visual impairment in children and adults - a systematic review妊娠史对神经管缺陷和艾森曼格综合征的影响：与儿童及成人智力障碍和视力障碍的关联——一项系统综述DOI: 10.3389/fped.2025.1522839
Clinical case reports IF: 00.600Volume 13, Issue 12No.212Comorbidity of Attention Deficit Hyperactivity Disorder (ADHD) and Chung-Jansen Syndrome: Case Report and Review of Literature注意缺陷多动障碍与钟-詹森综合征共病：病例报告及文献回顾DOI: 10.1002/ccr3.71593
Frontiers in nutrition IF: 05.100Volume 12, Issue No.213Weight loss increases circadian gene expression and emotional well-being in individuals with obesity减重可提升肥胖患者的昼夜节律基因表达和情绪健康水平DOI: 10.3389/fnut.2025.1722428
Frontiers in nutrition IF: 05.100Volume 12, Issue No.214The impact of high fructose corn syrup on liver injury and glucose metabolism: a systematic review高果糖玉米糖浆对肝损伤和葡萄糖代谢的影响：一项系统综述DOI: 10.3389/fnut.2025.1724398
Frontiers in public health IF: 03.400Volume 13, Issue No.215Navigating barriers and facilitators to lifestyle changes after bariatric surgery among Emirati adolescents: a qualitative study探索阿联酋青少年减重手术后的生活方式转变：障碍与促进因素的定性研究DOI: 10.3389/fpubh.2025.1702340
Eur J Paediatr Dent IF: 02.700Volume 26, Issue 4No.216SIOI Policy on Sugar Intake: Limiting Free Sugars from Earliest Days of Life to Prevent Caries, Specific Non-Communicable Diseases, and Tumors意大利儿科牙科学会（SIOI）关于糖摄入的政策：限制生命早期及终生的游离糖以预防龋齿、特定非传染性疾病与肿瘤DOI: 10.23804/ejpd.2025.26.04.02
The Journal of asthma IF: 01.300Ahead of Print.No.217Mediterranean Diet Adherence and Its Association with Inflammatory and Oxidative Stress Biomarkers in Asthma地中海饮食依从性及其与哮喘患者炎症和氧化应激生物标志物的关联DOI: 10.1080/02770903.2025.2592243
J Health Soc Behav IF: 03.600Ahead of Print.No.218Low-Density Zoning and Health Disparities in Metro Areas低密度分区与都市区健康差异DOI: 10.1177/00221465251391834
Rom J Morphol Embryol IF: 01.500Volume 66, Issue 3No.219An exploratory study on the impact of endocrine and infectious comorbidities on reproductive outcomes after Palmer-type neosalpingostomy关于内分泌及感染性共病对Palmer型输卵管再造术后生殖结局影响的探索性研究DOI: 10.47162/RJME.66.3.10
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.220P050 Impact of weight-loss interventions on psoriasis severity: a systematic review and meta-analysis减肥干预对银屑病严重程度的影响：一项系统回顾与荟萃分析DOI: 10.1093/bjd/ljaf085.078
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.221PD01 Liver fibroscanning identifies hepatic fibrosis at an early stage in erythropoietic protoporphyria: a new analysis in 132 patients肝纤维化扫描在132例红细胞生成性原卟啉病患者中早期识别肝纤维化：一项新的分析DOI: 10.1093/bjd/ljaf085.253
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.222SG15 Unravelling the risk factors for hidradenitis suppurativa: a genetic approachSG15 揭示化脓性汗腺炎的风险因素：一项遗传学方法DOI: 10.1093/bjd/ljaf085.524
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.223P101 Janus kinase inhibitors in palmoplantar pustulosis: a systematic review and meta-analysis of comorbidity burden to inform a feasibility trial's design (JAKPPPOT)Janus激酶抑制剂治疗掌跖脓疱病：一项针对共病负担的系统综述与荟萃分析，为可行性试验设计提供信息 (JAKPPPOT)DOI: 10.1093/bjd/ljaf085.129
BMC infectious diseases IF: 03.000Ahead of Print.No.224Effectiveness comparison of nirmatrelvir/ritonavir versus molnupiravir in COVID-19 patients with comorbidities in Taiwan: a multi-centre electronic health record study台湾COVID-19共病症患者中奈玛特韦/利托那韦与莫诺拉韦有效性比较：一项多中心电子健康记录研究DOI: 10.1186/s12879-025-12316-0
BMC surgery IF: 01.800Ahead of Print.No.225Predictors of acute gangrenous cholecystitis and its complications: a retrospective cohort study急性坏疽性胆囊炎及其并发症的预测因素：一项回顾性队列研究DOI: 10.1186/s12893-025-03356-z
BMC public health IF: 03.600Ahead of Print.No.226The relationship of the nutritional literacy level of individuals with diabetes on nutrition, quality of life, and metabolic control糖尿病患者的营养素养水平与其营养、生活质量和代谢控制的关系DOI: 10.1186/s12889-025-25948-3
BMC public health IF: 03.600Ahead of Print.No.227Promoting physical activity at Danish schools targeting youth who are not in employment, education or training (NEET): a qualitative study促进丹麦学校中针对未就业、未受教育或未接受培训（NEET）青年的体力活动：一项定性研究DOI: 10.1186/s12889-025-25879-z
BMC public health IF: 03.600Ahead of Print.No.228Global prevalence of multimorbidity among people living with type 2 diabetes: a systematic review and meta-analysis全球2型糖尿病患者中多病共患的患病率：一项系统综述和荟萃分析DOI: 10.1186/s12889-025-25570-3
Annals of surgical oncology IF: 03.500Ahead of Print.No.229ASO Author Reflections: Can Targeted Nutrition Level the Playing Field? Reflections on Preoperative Support for Malnourished Colorectal Cancer Patients in ERASASO作者述评：靶向营养支持能否改善公平性？——ERAS中营养不良结直肠癌患者术前支持的反思DOI: 10.1245/s10434-025-18832-2
Nature reviews. Endocrinology IF: 40.000Ahead of Print.No.230The hidden health effects of endocrine-disrupting chemicals内分泌干扰化学物质的隐匿健康效应DOI: 10.1038/s41574-025-01222-9
Nature communications IF: 15.700Ahead of Print.No.231Hepatic metabolic reprogramming in male mice during short-term caloric restriction involves enhanced glucocorticoid rhythms短期热量限制期间雄性小鼠的肝脏代谢重编程涉及增强的糖皮质激素节律DOI: 10.1038/s41467-025-67228-z
Nature communications IF: 15.700Ahead of Print.No.232In vivo base editing rescues ADPKD in a humanized mouse model体内碱基编辑在⼈源化⼩⿏模型中挽救ADPKDDOI: 10.1038/s41467-025-65997-1
J Cell Mol Med IF: 04.200Volume 29, Issue 23No.233Investigation of the Characteristics of Telomere Length in Koreans and Its Association With Chronic Metabolic Disorders: A Comprehensive Study韩国人端粒长度特征及其与慢性代谢性疾病关联的综合研究DOI: 10.1111/jcmm.70964
Primary care diabetes IF: 02.300Ahead of Print.No.234The U.S. diabetes belt and factors explaining the excess risk: Multifactorial modeling and machine learning analysis美国糖尿病带及其超额风险因素：多因素建模与机器学习分析DOI: 10.1016/j.pcd.2025.12.001
Clinics in shoulder and elbow IF: 01.700Ahead of Print.No.235Factors associated with shoulder function following ultrasound-guided hydrodilatation in patients with frozen shoulder: a prospective observational study冻结肩患者超声引导下液压扩张术后肩关节功能的相关因素：一项前瞻性观察研究DOI: 10.5397/cise.2025.00773
J Prev Med Public Health IF: 02.100Ahead of Print.No.236Feasibility and Preliminary Impacts of a Diabetes Education Chatbot Simulation on Glycemic Targets, Loneliness, and Health Beliefs: An Explanatory Mixed-methods Study一项解释性混合方法研究：糖尿病教育聊天机器人模拟的可行性与对血糖目标、孤独感及健康信念的初步影响DOI: 10.3961/jpmph.25.334
Epidemiology and health IF: 02.200Ahead of Print.No.237Dental implant removal rates and related factors in older adults in South Korea: a cross-sectional study using National Health Insurance Sharing Service Data韩国老年人种植牙移除率及相关因素分析：一项基于国民健康保险公团数据的横断面研究DOI: 10.4178/epih.e2025064
Epidemiology and health IF: 02.200Ahead of Print.No.238Cardiovascular Disease Risk Disparities between Immigrants and Native Koreans: A Population-Based Study in Gwangju, South Korea韩国光州的一项基于人群研究：移民与本土韩国人的心血管疾病风险差异DOI: 10.4178/epih.e2025067
Acta biomaterialia IF: 09.600Ahead of Print.No.239Engineered Cerium Oxide Nanoparticles Conjugated with Carrier Platforms: Therapeutic Mechanisms for Skin Wound Healing Applications工程化二氧化铈纳米颗粒偶联载体平台：用于皮肤伤口愈合应用的治疗机制DOI: 10.1016/j.actbio.2025.12.016
Practical radiation oncology IF: 03.500Ahead of Print.No.240Surgical Reconstruction Toxicity Following Hypofractionated Adjuvant Radiotherapy for Primary Cutaneous Melanoma原发性皮肤黑色素瘤大分割辅助放疗后的手术重建毒性研究DOI: 10.1016/j.prro.2025.11.004
Food and chemical toxicology IF: 03.500Ahead of Print.No.241Differential Effects on Acetaminophen-induced Nephrotoxicity and Liver Injury Following Modulation of Glutathione Resynthesis谷胱甘肽再合成调控对乙酰氨基酚诱导的肾毒性和肝损伤的差异效应DOI: 10.1016/j.fct.2025.115896
Experimental neurology IF: 04.200Ahead of Print.No.242Azeliragon attenuates cerebral infarction aggravation in diabetic rats: Receptor for advanced glycation end-product as a novel therapeutic target阿折拉贡减轻糖尿病大鼠脑梗死加重：晚期糖基化终末产物受体作为新型治疗靶点DOI: 10.1016/j.expneurol.2025.115588
Cell communication and signaling IF: 08.900Ahead of Print.No.243Phosphoproteomics unveils the signaling dynamics in neuronal cells stimulated with insulin and insulin-like growth factors磷酸化蛋白质组学揭示胰岛素和胰岛素样生长因子刺激神经元细胞的信号动态DOI: 10.1186/s12964-025-02573-6
Nature communications IF: 15.700Ahead of Print.No.244Imbalance of stem-like and effector T cell states in children with early type 1 diabetes across conventional and regulatory subsets儿童早期1型糖尿病中常规与调节性T细胞亚群内干细胞样与效应状态的失衡DOI: 10.1038/s41467-025-66459-4
Nature communications IF: 15.700Ahead of Print.No.2453D imaging of human pancreas suggests islet size and endocrine composition influence their loss in type 1 diabetes三维成像揭示人胰腺胰岛大小和内分泌组成影响其在1型糖尿病中的丢失DOI: 10.1038/s41467-025-66198-6
Nature communications IF: 15.700Ahead of Print.No.246Body-wide synchronization of insulin-signaling dependent DAF-16/FOXO nuclear translocation pulses correlated with C. elegans growth依赖胰岛素信号的DAF-16/FOXO核转位脉冲呈现全身同步化并与秀丽隐杆线虫的生长相关DOI: 10.1038/s41467-025-66164-2
Nature communications IF: 15.700Ahead of Print.No.247Proximity labeling of DAF-16 FOXO highlights aging regulatory proteinsDAF-16 FOXO的邻近标记揭示衰老调控蛋白质DOI: 10.1038/s41467-025-66409-0
Wiadomo?ci ParazytologiczneVolume 71, Issue No.248Detection of Serpentoplasma sp. (Apicomplexa: Haemohormidiidae) in dice snake (Natrix tesellata) (Colubridae: Natrix) in Azerbaijan在阿塞拜疆棋斑水蛇（Natrix tessellata）中检测到Serpentoplasma sp.（顶复门：血激素虫科）DOI: 10.17420/ap71.553
J Biol Chem IF: 03.900Ahead of Print.No.249KANK1 regulates the positioning of liprin-α1 and the spatial organisation of insulin granule fusion in pancreatic β cellsKANK1调控liprin-α1的定位及胰腺β细胞中胰岛素颗粒融合的空间组织DOI: 10.1016/j.jbc.2025.111036
Comput Biol Chem IF: 03.100Ahead of Print.No.250Apigenin potentiates glucose stimulated insulin secretion: A mechanistic insight into the mode of activation of PKA芹菜素增强葡萄糖刺激的胰岛素分泌：对蛋白激酶A激活机制的深入解析DOI: 10.1016/j.compbiolchem.2025.108796
Diabetes & metabolic syndrome IF: 03.400Ahead of Print.No.251The effects of low carbohydrate and high protein diet on the anthropometric indices, blood pressure, metabolic factors, and hormones related to metabolism: A systematic review and meta-analysis低碳水化合物高蛋白饮食对人体测量学指标、血压、代谢因素及代谢相关激素影响的系统综述与荟萃分析DOI: 10.1016/j.dsx.2025.103352
Scientific reports IF: 03.900Ahead of Print.No.252Integrative severity scale for diabetic macular atrophy and ischemia using structural OCT and OCT angiography采用结构OCT和OCTA的糖尿病性黄斑萎缩与缺血的综合严重程度分级DOI: 10.1038/s41598-025-31862-w
J Health Popul Nutr IF: 02.800Ahead of Print.No.253Age- and sex-specific reference values for plasma lipids and lipoproteins in thai adults: a national health examination survey analysis泰国成人血浆脂质与脂蛋白年龄-性别特异性参考值：一项全国健康调查分析DOI: 10.1186/s41043-025-01176-8
BMJ open IF: 02.300Volume 15, Issue 12No.254Associations of functional foods consumption with gastrointestinal and musculoskeletal conditions: a cross-sectional study among Bangladeshi adults功能性食品消费与胃肠道及肌肉骨骼疾病的关联性：一项孟加拉国成年人的横断面研究DOI: 10.1136/bmjopen-2025-103593
Scientific reports IF: 03.900Ahead of Print.No.255Efficacy and safety of pioglitazone versus dapagliflozin as an add-on to metformin and alogliptin combination therapy: the EPIDOTE study吡格列酮对比达格列净作为二甲双胍和阿格列汀联合治疗的添加治疗的有效性和安全性：EPIDOTE研究DOI: 10.1038/s41598-025-30882-w
Updates in surgery IF: 02.200Ahead of Print.No.256Commentary on "Unappreciated, undervalued, and working in a toxic environment: the silent struggles of some surgeons"评论“不受赏识、价值被低估，并在有毒环境中工作：一些外科医生的默默挣扎”DOI: 10.1007/s13304-025-02488-4
International journal of obesity IF: 03.800Ahead of Print.No.257Preoperative 24-hour movement behaviors and early weight loss after metabolic bariatric surgery: a compositional analysis术前24小时运动行为与代谢性减重手术后早期体重减轻：一项成分分析DOI: 10.1038/s41366-025-01983-3
Surgical endoscopy IF: 02.700Ahead of Print.No.258Special findings in high-resolution manometry prior to metabolic surgery: obesity as a risk factor for esophagogastric junction outflow obstruction or achalasia?代谢手术前高分辨率测压的特殊发现：肥胖是食管胃结合部流出道梗阻或贲门失弛缓症的危险因素？DOI: 10.1007/s00464-025-12472-z
Pediatric research IF: 03.100Ahead of Print.No.259Relationship between serum lipids/adipokines and obesity/hypertension in very-preterm infants during early childhood and preadolescence极早产儿在幼儿期和青春期前血清脂质/脂肪因子与肥胖/高血压的关系DOI: 10.1038/s41390-025-04578-w
Nature medicine IF: 50.000Ahead of Print.No.260Implementation and effectiveness of a care process to prioritize weight management in primary care: a stepped-wedge cluster-randomized trial初级保健中优先体重管理的护理流程的实施与效果：一项阶梯式楔形整群随机试验DOI: 10.1038/s41591-025-04051-5
Scientific reports IF: 03.900Volume 15, Issue 1No.261Pharmacological and toxicological insights into the ayurvedic formulation Rasasindura阿育吠陀制剂Rasasindura的药理学与毒理学见解DOI: 10.1038/s41598-025-97062-8
J Hum Nutr Diet IF: 02.500Volume 38, Issue 6No.262The Efficacy and Safety of a Preoperative Dietitian-Led Very Low Calorie Diet Clinic for Adults With Obesity for Colorectal Cancer Surgery: A Retrospective Cohort Study营养师主导的术前极低热量饮食门诊对计划接受结直肠癌手术的肥胖成年人的有效性与安全性：一项回顾性队列研究DOI: 10.1111/jhn.70178
Am J Clin Nutr IF: 06.900Ahead of Print.No.263Dietary fats, blood lipids and atherosclerotic cardiovascular disease: time for food-based approach?膳食脂肪、血脂与动脉粥样硬化性心血管疾病：食物导向策略的时机？DOI: 10.1016/j.ajcnut.2025.11.007
Obes Res Clin Pract IF: 02.300Ahead of Print.No.264Development and early evaluation of OPTIMAP: A digitally enabled nurse-led multidisciplinary pathway for care of people with severe obesity in a Public Australian Health NetworkOPTIMAP：在澳大利亚一公共医疗网络中，为严重肥胖患者开发的数字赋能护士主导多学科护理路径及其早期评估DOI: 10.1016/j.orcp.2025.12.004
Obes Res Clin Pract IF: 02.300Ahead of Print.No.265Vitamin D, adiposity, and cardiometabolic risk: Insights from a multivariable cross-sectional study维生素D、肥胖与心脏代谢风险：来自一项多变量横断面研究的启示DOI: 10.1016/j.orcp.2025.12.005
Surg Obes Relat Dis IF: 03.800Ahead of Print.No.266Impact of preoperative and postoperative anti-obesity medications on early postoperative body mass index reduction after sleeve gastrectomy in pediatrics袖状胃切除术前和术后使用抗肥胖药物对儿科患者早期术后体重指数减少的影响DOI: 10.1016/j.soard.2025.10.019
Expert opinion on drug discovery IF: 04.900Ahead of Print.No.267Advancing obesity treatments through innovations in the design and manufacturing of therapeutic peptides通过治疗性肽的设计与制造创新推进肥胖治疗DOI: 10.1080/17460441.2025.2601113
Pediatric obesity IF: 02.700Volume 21, Issue 1No.268Acute Exercise-Induced Energy Expenditure and Substrate Oxidation Rates Might Not Be Associated With Subsequent Appetitive Responses in Adolescents Living With Obesity急性运动诱导的能量消耗与底物氧化率可能与肥胖青少年随后的食欲反应无关DOI: 10.1111/ijpo.70073
Epidemiology and health IF: 02.200Ahead of Print.No.269The discriminatory ability of the body roundness index and body mass index for metabolic diseases in Korean adults: a comparative study身体圆度指数与身体质量指数对韩国成年人群代谢疾病的判别能力：一项比较研究DOI: 10.4178/epih.e2025069
Physiology & behavior IF: 02.500Ahead of Print.No.270The combination of physical activity and late-time-restricted eating improves eating behavior, cognitive performance and cardiovascular parameters in women living with excess body weight体力活动与晚间限时饮食相结合可改善超重女性的饮食行为、认知表现和心血管参数DOI: 10.1016/j.physbeh.2025.115200
Appetite IF: 03.800Ahead of Print.No.271No heightened temporal attentional bias towards food or overweight bodies in adolescents with obesity青少年肥胖患者对食物或超重身体不存在更强的时间性注意偏倚DOI: 10.1016/j.appet.2025.108417
Molecular metabolism IF: 06.600Ahead of Print.No.272The Innate Thermogenic Capacity of Brown Adipose Tissue Develops Independently of Sympathetic Signaling棕色脂肪组织的先天产热能力独立于交感神经信号而发育DOI: 10.1016/j.molmet.2025.102299
Brain & development IF: 01.300Ahead of Print.No.273Brain health in youth - what are we measuring? - A comprehensive review青少年脑健康——我们测量的是什么？一项全面综述DOI: 10.1016/j.braindev.2025.104491
Science of the total environment IF: 08.000Ahead of Print.No.274Ethylparaben and consumer chemicals and their associations with metabolic disorders: A multicycle analysis of Korean National Environmental Health Survey (2015-2020)乙基对羟基苯甲酸酯及消费品化学物质与代谢紊乱的关联：基于韩国国家环境健康调查（2015-2020）的多周期分析DOI: 10.1016/j.scitotenv.2025.181128
Nutrition IF: 03.000Ahead of Print.No.275Evaluation of obesity phenotypes from childhood to adolescence: Does diet quality in childhood matter? (PASE Study-Brazil)从儿童期到青少年期肥胖表型评估：儿童期饮食质量重要吗？（巴西PASE研究）DOI: 10.1016/j.nut.2025.113027
Phytomedicine IF: 08.300Ahead of Print.No.276Anti-adipogenic effect of cryptotanshinone in 3T3-L1 preadipocytes via binding to glucagon-like peptide 1 receptor and its signaling隐丹参酮通过结合胰高血糖素样肽1受体及其信号通路在3T3-L1前脂肪细胞中发挥抗脂肪生成作用DOI: 10.1016/j.phymed.2025.157666
J Trace Elem Med Biol IF: 03.300Ahead of Print.No.277Association between serum chromium and nickel levels with metabolic markers and HOMA-β in overweight and obese adults超重及肥胖成年人的血清铬、镍水平与代谢标志物及HOMA-β的关联性研究DOI: 10.1016/j.jtemb.2025.127803
Gynecologic oncology IF: 04.100Ahead of Print.No.278Associations between obesity and outcomes in pembrolizumab-treated endometrial cancer帕博利珠单抗治疗的子宫内膜癌患者中肥胖与预后之间的关联DOI: 10.1016/j.ygyno.2025.12.001
Epilepsy & behavior IF: 02.300Ahead of Print.No.279Health risk factors and polypharmacy in people with epilepsy and their association with multimorbidity: a single centre retrospective study癫痫患者的健康风险因素与多药治疗及其与共病的关联：一项单中心回顾性研究DOI: 10.1016/j.yebeh.2025.110829
Cardiovasc Diabetol Endocrinol RepVolume 11, Issue 1No.280Chronic hyperglycemia and cardiovascular dysfunction: an in-depth exploration of metabolic and cellular pathways in type 2 diabetes mellitus慢性高血糖与心血管功能障碍：深入探索2型糖尿病的代谢与细胞通路DOI: 10.1186/s40842-025-00247-3
BMC Cardiovascular Disorders IF: 02.300Ahead of Print.No.281Association between atherogenic index of plasma and various metabolic conditions: an umbrella review on meta-analyses血浆致动脉粥样硬化指数与多种代谢状况的关联：一项关于Meta分析的伞状评价DOI: 10.1186/s12872-025-05409-w
Scientific reports IF: 03.900Ahead of Print.No.282Association of glycemic variability with oxidative stress and AGE accumulation in type 2 diabetes2型糖尿病中血糖变异性与氧化应激及AGE积累的关联DOI: 10.1038/s41598-025-31845-x
BMC Complement Med Ther IF: 03.400Ahead of Print.No.283GB5, a synergistic phytotherapy for type 2 diabetes mellitus management: an integrated polyherbal approach from phytochemical profiling to network pharmacologyGB5：一种用于管理2型糖尿病的协同植物疗法——从植物化学分析到网络药理学的综合复方草药方法DOI: 10.1186/s12906-025-05192-3
Journal of clinical apheresis IF: 02.700Volume 40, Issue 6No.284A Simplified Scoring System to Predict In-Hospital Mortality of Leukapheresis in Patients With Leukemia用于预测白血病患者白细胞分离术住院死亡率的简化评分系统DOI: 10.1002/jca.70078
Sleep & breathing IF: 02.000Volume 30, Issue 1No.285The impact of sleep disturbances in individuals with comorbid diabetes and chronic kidney disease: a systematic review睡眠障碍对合并糖尿病与慢性肾脏病个体健康影响：一项系统综述DOI: 10.1007/s11325-025-03552-4
J Infect Public Health IF: 04.000Ahead of Print.No.286The impact of sodium-glucose co-transporter 2 inhibitors on the incidence of non-tuberculous mycobacteria infection in diabetes populations钠-葡萄糖协同转运蛋白2抑制剂对糖尿病人群非结核分枝杆菌感染发生率的影响DOI: 10.1016/j.jiph.2025.103089
European journal of pediatrics IF: 02.600Volume 185, Issue 1No.287Early kidney damage in children and adolescents with primary arterial hypertension: a systematic review儿童和青少年原发性动脉高血压的早期肾脏损伤：一项系统综述DOI: 10.1007/s00431-025-06671-y
283
Diabetes Mellitus(DM)
糖尿病
127
Obesity
肥胖症
75
Insulin
胰岛素
25
Type 2 diabetes mellitus(T2DM)
2型糖尿病
16
Metformin
二甲双胍
15
Metabolic Syndrome
代谢综合征
11
Diabetic Kidney Disease(DKD)
糖尿病肾脏病
11
Diabetic Retinopathy
糖尿病视网膜病
9
Glucagon-Like Peptide-1 Receptor Agonists(GLP-1RA)
胰高血糖素样肽-1受体激动剂
8
Hypoglycemic Agents
降糖药
8
Gestational Diabetes Mellitus(GDM)
妊娠糖尿病
7
Semaglutide
司美格鲁肽
7
Dapagliflozin
达格列净
6
Diabetic Foot
糖尿病足
6
Type 1 diabetes mellitus(T1DM)
1型糖尿病
5
Diabetic Neuropathies
糖尿病性神经病变
4
Liraglutide
利拉鲁肽
3
Gabapentin
加巴喷丁
3
Pregabalin
普瑞巴林
3
Empagliflozin
恩格列净
3
Diabetes Complications
糖尿病并发症
2
Canagliflozin
卡格列净
2
Sotagliflozin
索格列净
2
gamma-Aminobutyric Acid(GABA)
γ-氨基丁酸
2
Tirzepatide
替尔泊肽
2
Dulaglutide
度拉糖肽
2
Dipeptidyl-Peptidase IV Inhibitors(DPP-4i)
二肽基肽酶-4抑制剂
1
Vildagliptin
维格列汀
1
Alogliptin
阿格列汀
1
Exenatide
艾塞那肽
1
Gastrointestinal lipase inhibitor
胃肠道脂肪酶抑制剂
1
Orlistat
奥利司他
1
Diabetic acidosis
糖尿病性酸中毒
1
Diabetic Cardiomyopathies
糖尿病心肌病
1
Ertugliflozin
艾托格列净
1
Sodium-Glucose Transporter 2 Inhibitors(SGLT-2i)
钠-葡萄糖协同转运蛋白2抑制剂
编辑：丁克芳
审校：丁克芳
2025-12-09
摘要
我国古代人民在数千年来与疫病斗争的过程中积累了丰富的经验，建立了行之有效的中医疫病理论体系并应用至今。芳香类中药的应用在中医疫病理论体系和疫病防治史上占据重要地位，芳香类中药防治疫病有着深厚的中医学理论基础和丰富的现代科学研究证据支持，具备全方位整体调节、全过程精准干预、多途径多维起效和安全性稳定可靠等独特优势，临床实践中展现出整体性、全面性、灵活性和时相性等特点，理论和防治经验均具有较高的实用价值。本文通过综述芳香类中药防治疫病的理论内涵、作用机制和临床应用优势，分析面临的挑战，提出未来的展望，旨在完善中医疫病相关理论和提高疫病防治水平。
疫病是由疫疠病邪引起的具有强烈传染性和广泛流行性的一类外感病，其致病因素具有特异性，且发病常表现出一定的季节性与地域性。在现代医学体系中多与传染病相对应，部分甚至属于烈性传染病范畴。疫病的致病因素即疫疠病邪较为特殊，患者感触疫疠病邪后往往起病急骤，发展迅速，引起广泛流行。患者大多病情严重，遗留后遗症，甚至死亡。据文献记载，从西汉至清朝末年，中国至少发生了500余次大型疫病。到近现代，从鼠疫、霍乱到严重急性呼吸综合征（SARS）、甲型流感病毒（H1N1）、新型冠状病毒感染（COVID-19）等疫病的频发凸显了发展有效防治策略的紧迫性。目前传统的防治手段包括疫苗、小分子药物和抗体药物等，但是由于新发突发传染病的不可预测性、病毒变异的速度、研发周期以及部分化学药物的副作用和耐药性等限制因素，导致在应对高变异性的突发病毒感染性疾病方面存在一定的局限。
在长期与疫病斗争的过程中，中医药发挥了重要作用，积累了丰富的理论和实践经验，形成了独特的“防疫治疫”体系。其中，芳香中药因药性独特、疗效确切、自成体系，在防疫抗疫中受到历代医家重视，留下了大量文字记载与成功治验。芳香类中药是指以挥发性物质为主要成分，具有芳香气味的中药，古代医家常称之为“芳草”“香木”或“芳香药”。芳香类中药具有扶正辟秽、解表散邪、健胃悦脾、化湿醒脾、走窜通达等功效，因其在辟秽解毒及疾病预防与治疗方面的显著作用，被广泛应用于防病、疗疾、康复、养生等众多领域。现代研究表明，芳香类中药多富含挥发性成分，具有广谱的抗菌、抗病毒、抗炎、调节免疫以及心理调节等多重药理活性，随着研究的不断深入，芳香类中药治疗效果不断得到确证。因此，本文通过总结芳香类中药防治疫病的理论及临床应用研究进展，分析面临的挑战，提出未来展望，旨在进一步阐释科学内涵，发掘其临床价值，为我国新发突发传染病的防治提供理论支撑，拓展防控未来病毒风险的思路。
1
芳香类中药防治疫病的中医学认识
1.1 芳香类中药防治疫病的理论基础
早在5 000多年前，我国就有使用芳香类中药祛邪辟秽、防疫治病的文字记载。殷商甲骨文中有“鬯其酒”的记载。1972年马王堆出土的香囊、香炉和枕头中就装有辛夷、佩兰、花椒、高良姜等芳香类药物。唐代《备急千金药方》“辟温”专篇中亦提及多种辟疫气、令人不染温病及伤寒的方药和治法，药物均以芳香类药物为主，如岁旦屠苏酒、太一流金散、雄黄散、一物柏枝散等，治法涵盖内服、佩香、焚香、涂抹、纳鼻等多种方式。
宋代以后逐渐形成芳香药物理论，成为中药药性理论的重要组成部分。明代《本草纲目》对芳香类中药做了系统归类，载有“芳草类”56种和“香木类”35种，其大多具有解除表邪、化湿除秽、行气活血、开窍醒神之功；并留存木香主治“邪气，辟毒疫温鬼，强志”，山柰主治“辟瘴疠恶气”，乌药主治“天行疫瘴”等预防疫病的文字记载。明代倪朱谟《本草汇言》亦按《本草纲目》分类，在草部中专列“芳草类”，载芳草35种，在木部中专列“香木类”，载香木39种，对诸多芳香类中药的功效进行了进一步阐述。
明清时期是疫病学研究发展的重要时期，以芳香药物防治疫病的理论系统在此期间逐渐形成。明代吴有性认为温疫的传染性强烈，以六淫学说难以解释，因而提出“温疫之为病，非风、非寒、非暑、非湿，乃天地间别有一种异气所感”，而“邪自口鼻而入，则其所客，内不在脏腑，外不在经络，舍于夹脊之内”，首创“邪伏膜原”之说。针对“异气”，吴氏认为客邪贵乎早逐，创立了芳香逐秽、开达膜原的“达原饮”，并成为其治疗疫病最有代表性的方剂。清代叶桂在《临证指南医案》中指出：“夫疫为秽浊之气，古人所以饮芳香，采兰草，以袭芬芳之气者，重涤秽也”，提出疫疠秽浊之气弥漫三焦时，污秽须逐，浊邪当化，当以芳香化浊法驱逐秽邪，临证多用佩兰、藿香、草果、白豆蔻等芳香之药治之；若疫疠之邪入于膻中，邪干心包，蒙闭心窍，则以芳香宣窍法逐秽开窍，临证多用安宫牛黄丸、至宝丹或苏合香丸治之。吴鞠通在《温病条辨》中，详细记载温病的理法方药，其所创立的三焦辨证进一步完善了温病的辨证论治体系。吴氏在病因方面提出“温疫者，厉气流行，多兼秽浊”“温毒者，诸温夹毒，秽浊太甚也”，认为疫疠为秽浊之气，若秽浊不正之气弥漫，必用芳香以开其蒙闭之秽浊，以其芬芳之气辟秽化浊，且芳香性味本身就有逐秽辟邪之能，辛香更能流动气机，增强逐秽之功，因此在疫病的治疗中多配伍辛香药物以辟秽化浊，其中以公丁香、川椒、草果、小茴香、降香、雄黄等为辛温芳香逐秽的代表药物。同时，在临床治疗温疫时，吴氏常有“芳香透络逐秽”“芳香护膻中定神明之乱”“芳香开膻中”“湿中秽浊，需重用芳香”“芳香化浊”等相关论述和临证感悟。清代李炳《辨疫琐言》基于“疫为阴浊”，提出瘟疫应治之以轻清芳香，以清化浊，祛除浊邪而复清阳，确立“轻清以开肺舒气”的治则，自创治疫主方“清气饮”，强调金银花、藿香、苏叶芳香辟浊，散胸中不正之气，旨在芳香以醒胃辟邪。民国医家周禹锡提出芳香逐秽理论，认为芳香药物可散邪辟秽、宣通气机而使瘟疫毒气外达，自拟加味清芳辟瘟汤，用药常以鲜青蒿叶、菖蒲叶、泽兰叶、薄荷叶等新鲜花、叶为主。以上医家的理论论述和临床治验，为“运用芳香类中药防治疫病”这一思路奠定了坚实的理论基础。
1.2 芳香类中药防治疫病的药物功效
芳香类中药其味芬芳清冽，多辛温善散，归脾胃经居多，其次归肝肺经，故芳香类中药在外可开皮毛通腠理，在上能通鼻窍清头目，在中能开胸膈醒脾胃，理中州化痰饮，行气滞解郁结。芳香类中药防治疫病的功效可涵盖化湿辟秽、辛香宣透、行气解郁、扶助正气、醒神开窍等诸多方面。
1.2.1 化湿辟秽
化湿辟秽作用与芳香化浊，醒脾开胃功效相关。《本草正义》认为疫气乃湿浊秽腐之气，由口鼻入胃，芳香类中药可助脾胃而无流弊，能祛除阴霾湿邪，扶助脾胃正气，故有“芳香能助中州清气，胜湿辟秽”“辟秽恶，解时行疫气”之功效，并认为“凡芳香行气，醒脾胜湿诸芳草，皆有同情，不仅藿香、木香一类为然也”。缪希雍《神农本草经疏》有“芳香之气，能辟一切邪恶；辛热之性，能散一切风湿，故主心腹邪气及风湿积聚也”“芬芳能除秽恶”等论述。叶天士认为秽与岚瘴、疫疠有诸多相关之处，秽必夹湿，当以芳香辟秽之品治之，如《叶天士晚年方案真本》载：“臭秽不正之气入自口鼻，着于募原……宣通浊痹为正，发散清寒为忌。草果、槟榔、藿梗、厚朴、杏仁、白蔻、半夏、姜汁” 。
1.2.2 辛香宣透
温邪上受，首先犯肺，疫气最易侵袭呼吸系统，故预防疫病，应先切断疫气传播途径。芳香类中药的辛散之力促使肺气上行，肺气行则宣发，可疏风散邪，上行头目清窍，达表解肌，驱邪外出，达到防疫的目的。王旭高《运气证治歌诀》提及《韩氏医通》治瘟疫的五瘟丹时指出“盖香附、紫苏，芳香辛散，足以辟邪”。《神农本草经百种录》曰：“凡药香者，皆能疏散风邪。”《本草正义》认为芳香之品能“疏散肺闭，宣通肌表，泄风化邪，最为敏捷”。
1.2.3 行气解郁
芳香中药多具辛味，辛者能散能行，故芳香类中药常有行气解郁之功。《本草求原》记载苍术“温，甘、苦、辛而燥，芳香四达，升发谷气，疏泄胃气，以解诸郁”，沉香“气香扶脾，故理诸气，调中气，开郁气”，乳香“能由血达气，即达阳归阴，故活血调气”。吴仪洛在《本草从新》提及甘松香“辛、甘，温，芳香理诸气，开脾郁”，乌药“辛、温，香窜。上入脾肺，下通膀胱与肾，能疏胸腹邪逆之气，一切病之属气者，皆可治”，芳香馥郁之气辛香开发，辛散可散结滞，常有理气调气、开郁行气、使气机条畅之功效。
1.2.4 扶助正气
《黄帝内经素问》曰：“不相染者，正气存内，邪不可干，避其毒气”，明确提出疫病防治的关键为正气的充足与否。《神农本草经百种录》论及芳香药物时曰：“香者气之正，正气盛，则自能除邪辟秽也。”《本草求原》亦多次提及香药的扶正之功，如“香为天地正气，正气胜则邪恶散”“时气，寒气疫，香能正气”。张山雷则认为“清芬之气能助人振刷精神，故使耳目聪明、九窍通利”，因而关窍通灵而脏气自得补益，清阳振动而辟除秽浊之气，从而达到芳香扶正辟秽与芳香驱邪辟秽的双重功效。
1.2.5 开窍醒神
《神农本草经疏》认为芳香类中药“气芳烈，味大辛，阳中之阳，升也，散也。性善走窜开窍，无往不达” 。因此，芳香类中药气味浓郁而攻窜，能通九窍、剔瘀浊，有开窍醒神之功，如闭证患者缪氏常以开关散揩牙促其苏醒，“用龙脑、天南星，等分为末，每以一字揩齿二三十遍，其口自开”。《本草备要》屡次提及芳香药物的“香窜”“走窜”之特点，有诸如乳香“香窜入心”，冰片“辛温香窜，善能走散……通诸窍”，苏合香“甘温走窜，通窍开郁”的文字叙述。吴鞠通在《温病条辨》中提出芳香之品能“芳香化秽浊而利诸窍”。吴氏善用芳香药治疗热闭证，如以安宫牛黄丸清热解毒，豁痰开窍；以紫雪丹清热开窍，息风止痉；以至宝丹清热开窍，化浊解毒，达到“诸香化秽浊或开上窍，或开下窍，使神明不致坐困于浊邪”之效。根据具体药物的不同，芳香药物的通窍之功又有通鼻窍、毛窍、心窍、脑窍和下窍之别。
2
芳香类中药防治疫病的科学内涵
近年来，大量临床与实验研究均证实了芳香类中药在疫病防治方面具有显著疗效，同时其科学内涵亦得到了全面阐释与验证。现代药理学的研究深入揭示了芳香类中药防疫抗疫作用的多重机制，涵盖抗菌抑制病毒复制增殖、抗炎减轻器官损伤以及遏制细胞因子风暴等多方面。
2.1 抗菌抑制病毒复制增殖
研究发现，芳香类中药的挥发性成分在体外和体内对肺系疾病致病菌均有良好的抗菌活性，且较少产生耐药。实验研究表明，黄连、黄芩对金黄色葡萄球菌和大肠埃希菌具有良好的抑菌活性，前胡精油对大肠杆菌、铜绿假单胞菌和产气肠杆菌能产生显著抑制作用，白术根茎挥发油具有抑制大肠杆菌、铜绿假单胞菌、肠炎沙门氏菌、金黄色葡萄球菌和枯草芽孢杆菌生长的作用，最低抑菌浓度（MIC）在0.5~2.0 mg⋅mL-1。除了直接抗菌作用外，芳香类中药还能通过对免疫、非免疫微环境、细胞膜结构和微循环的影响发挥间接抗菌作用，通过直接杀灭病毒、抑制病毒复制、阻断与受体结合、抑制细胞因子/趋化因子的反应、增强免疫系统等途径达到抗病毒的目的。如金银花对流感病毒、呼吸道合胞病毒（RSV）、H9亚型禽流感病毒（H9-AIV）、肠道病毒71型（EV71）、单纯疱疹病毒、甲型流感病毒等具有广泛的抗病毒作用。广藿香醇是广藿香挥发油的代表性成分，实验证明广藿香醇可以通过靶向细胞PI3K/Akt和ERK/MAPK信号通路灭活病毒颗粒并干扰病毒吸附，抑制甲型流感病毒，其改善小鼠存活和减轻肺炎症状的效果与奥司他韦相当。由青蒿、金银花、栀子组成的热毒宁注射液能抑制流感病毒诱导的MDCK细胞病变，降低流感病毒M2蛋白水平和病毒毒力，通过激活MAPK/Nrf2/HO-1信号通路发挥抗流感病毒作用。
2.2 抗炎减轻器官损伤
芳香类中药具有抑制炎症及氧化应激反应的良好作用，其抗炎活性在疾病的宏观临床特征、器官生理病理变化和炎性细胞浸润等不同方面均得以体现。芳香类中药所含的活性物质往往具有抗炎减轻器官损伤的作用。作为COVID-19治疗“三方三药”之一的清肺排毒汤由麻黄、杏仁、桂枝等21味中药组成。清肺排毒汤能通过抑制热敏通道瞬时受体电位香草酸受体1（TRPV1）、瞬时受体电位锚蛋白1（TRPA1）的表达，抑制核转录因子κB（NF-κB）通路活化，降低肿瘤坏死因子-α（TNF-α）、白介素-6（IL-6）水平，减少炎症细胞浸润，减轻肺水肿和肺组织的病理损伤，被证明具有较好的抗炎和器官保护作用。清瘟止咳方能使脂多糖（LPS）诱导的急性肺损伤大鼠模型白细胞计数和肺泡壁的变化恢复正常，降低促炎因子IL-6、TNF-α、单核细胞趋化蛋白-1（MCP-1）、IL-1β、IL-18和干扰素γ（IFN-γ）的过表达，下调Toll样受体4（TLR4）、磷酸化核因子κB抑制物激酶α/β（p-IKKα/β）、活化的半胱天冬酶-1（Cleaved caspase-1）的过表达，通过抑制TLR4/NF-κB信号通路和NLRP3炎性小体达到抗炎和减轻肺损伤的目的。
2.3 遏制细胞因子风暴（Cytokine storm，CS）
CS是机体对外界刺激产生的免疫过激反应，其特征是免疫细胞的持续激活和炎性细胞因子、化学介质的无序释放，表现为外源性致病原侵入后机体促炎/抗炎机制失衡，进而引起高炎性状态下的组织损伤与多器官功能衰竭。
芳香类中药能多靶点、多通路地抑制免疫反应的过度激活以及细胞因子的过度表达。例如杏仁-黄芩药对在COVID-19的治疗中通过调控氧化应激的反应、细胞因子介导的信号通路、炎症反应的调节、细胞对有毒物质的反应等生物学进程达到抑制CS、止咳等药理作用。青蒿琥酯及清肺排毒汤可以快速募集免疫细胞到达病原位置，清除病原体，抑制细胞因子的过度表达，达到减轻高强度炎症反应的目的。清肺排毒汤使感染冠状病毒229E株的Huh7细胞所分泌的TNF-α、IL-1β、IL-6、IFN-γ mRNA表达降低，且降低培养上清中的相应蛋白，提示清肺排毒汤可能并非通过抑制炎细胞趋化因子和病毒复制起作用，而是通过抑制CS中的炎性细胞因子达到治疗目标。
此外，研究发现细胞因子如IL-6、TNF-α、IL-1β，趋化因子MCP-1、干扰素诱导蛋白10（IP-10）在呼吸道病毒感染患者中的升高程度与疾病严重程度呈正相关。热毒宁注射液能显著降低单链RNA诱导的炎症因子IL-6、TNF-α、IL-1β和趋化因子的产生，降低巨噬细胞数量并抑制炎症反应，证明可以通过遏制CS缓解系统性炎症反应综合征和器官损害。麻杏石甘汤可以促进辅助性T细胞（Th细胞）分化和T细胞稳态，负调控免疫炎性反应递质如TNF、白细胞介素、整合素等，多成分、多靶点抑制病毒复制并消除CS。
2.4 抗氧化作用
病原微生物入侵机体后，产生的炎性因子和细胞因子风暴可使体内活性氧（ROS）过度生成，产生大量自由基诱发氧化损伤，导致多器官损害。因此氧化应激作为感染后诱发急性肺损伤的作用机制之一，是导致肺泡水肿、炎性细胞过度浸润、弥漫性肺间质病变并进而发展为急性缺氧性呼吸功能不全的重要病理机制。芳香类中药的挥发性成分具有良好的抗氧化作用，可清除自由基，减少氧化损伤。有研究对金花清感颗粒在挥发性油气体状态下的抗氧化活性进行评估，认为萜类和醛酮、酚酸等化合物包括罗勒烯、α-细辛脑等是其主要的抗氧化活性成分，对2，2′-联氮-双（3-乙基苯并噻唑啉-6-磺酸）（ABTS）的清除率达88.95%，具有显著抗自由基能力。芳香类中药中富含的连翘苷、木犀草素、红景天苷、黄芩素、白藜芦醇、橙皮素等抗氧化活性产物也被证实在传染性疾病的治疗中发挥了重要作用。
2.5 抗补体活化
补体系统是先天性免疫系统的重要组成部分，在免疫防御、免疫监视和免疫自稳过程中发挥着关键作用，而补体系统的过度活化可能导致细胞因子风暴、内皮炎症以及血栓形成，是引起炎症、凝血功能障碍和内皮损伤的重要病理环节。抑制补体的过度激活可预防COVID-19患者急性呼吸窘迫综合征相关的肺部炎症和血管内皮炎。柴胡能显著减少LPS诱导的THP-1细胞分泌致热因子TNF-α，在体内和体外均能抑制补体激活，因此补体活化可以作为柴胡解表退热的敏感生物活性指标。宣肺败毒方可显著降低免疫球蛋白G（IgG）免疫复合物（IgG-IC）诱导急性肺损伤（ALI）小鼠模型血清中C3a和C5a水平，通过抑制JAK2/STAT3/SOCS3和NF-κB信号通路，抑制补体的过度激活，改善急性肺损伤。治疗COVID-19的“抗疫三方”（清肺排毒汤、化湿败毒方和宣肺败毒方）经实验证明均能减少IgM引起的C5b-9的生成，抑制IgM启动的补体经典活化途径，具有体外抗补体活化作用。
2.6 调节免疫应答
芳香类中药对固有免疫应答和适应性免疫应答均能产生显著的调节作用。研究发现芳香类中药的挥发油通过对中性粒细胞、巨噬细胞、树突状细胞（DC）的调节，影响吞噬作用、抗原呈递、炎症介质的释放和细胞因子的产生，并针对B细胞介导的体液免疫以及T细胞介导的细胞免疫，调控特定抗原或靶细胞，发挥特异性免疫应答作用。DC是专门的抗原呈递细胞（APCs）和哨兵细胞，负责调节免疫反应。乳香挥发油能干扰单核细胞向DC的分化，抑制作用在分化、成熟标志物表达、细胞因子产生和脂多糖刺激的单核细胞衍生DC的方面尤为显著，可作为人外周血单核细胞衍生DC的免疫抑制剂。
2.7 改善胃肠功能障碍
在感染等急性应激状态下，胃肠道黏膜缺血缺氧导致胃肠屏障功能下降，条件致病菌及内毒素入侵加重炎症反应，进一步发展为多器官功能障碍综合征。广藿香醇是一种针对炎症和肠道屏障损伤的天然倍半萜，能降低血清中TNF-α、IFN-γ、IL-1β、IL-6和IL-17水平，降低促炎细胞因子的mRNA表达，上调紧密连接蛋白的表达并保护上皮屏障完整性，修复宏观结肠病变和组织损伤。苍术是常用防疫药物，古籍中多有“避一切恶气”“最能驱除秽浊恶气”的文字记载。在药理学研究中，除了抗炎、抗菌、抗病毒的作用外，苍术同时具有良好的调节胃肠功能作用。苍术有效成分能增加胃泌素（GAS）、胃动素（MTL）水平，改善胃排空及小肠推进率，降低血管活性肠肽（VIP）水平，双向调节胃肠功能紊乱，减轻胃肠组织损伤和结构异常。苍术素在人胃平滑肌细胞中能激活生长激素促分泌素受体（GHSR），升高钙离子（Ca2+）浓度，增强肌球蛋白轻链（MLC）的磷酸化并促进胃排空。
2.8 重要器官的保护作用
感染性疾病中巨噬细胞和细胞因子在特定病理条件下形成正反馈调节机制形成细胞因子风暴，大量的炎症因子引发全身炎症反应综合征，造成细胞免疫缺陷、凝血激活、心肌损伤、肝损伤以及肾脏损伤。研究发现苍术对肺脏、心脏、肝脏、胃肠道等重要器官有显著保护作用。苍术素能抑制急性肺损伤模型小鼠支气管肺泡灌洗液（BALF）中TNF-α、IL-6、IL-1β和单核细胞趋化蛋白（MCP-1）水平，降低髓过氧化物酶（MPO）的活性、蛋白质渗漏和肺组织湿干重比，提示苍术素可能通过抑制NOD样受体蛋白3（NLRP3）炎性小体和TLR4的激活，对LPS诱导的急性肺损伤炎症反应具有抑制炎症反应并减轻肺部损伤的作用。苍术挥发油能够提高H9c2心肌细胞的存活率，上调B淋巴细胞瘤-2（Bcl-2）mRNA和蛋白的表达，下调半胱氨酸天冬氨酸蛋白酶-3（Caspase-3）、Bcl-2同源的水溶性相关蛋白（Bax）mRNA表达，提高超氧化物歧化酶（SOD）活力，降低乳酸脱氢酶（LDH）和丙二醛（MDA）含量，苍术挥发油对缺氧/复氧（H/R）损伤心肌细胞具有抗氧化和抗凋亡的作用。除此之外，苍术还具有神经保护、调节免疫和镇痛等多重功能。
3
芳香防疫临床应用的独特优势
中药复方具有多成分、多靶点、多通路、多药效的协同作用特征。在此基础上，芳香中药在防疫抗疫实践中，进一步展现出全方位整体调节、全过程精准干预、多途径多维起效及安全性稳定可靠的优势。
3.1 全方位整体调节
芳香类中药在防疫抗疫过程中表现出“多靶点作用”的整体调节优势。芳香类中药具有防疫独特性，当前研究多将挥发油成分作为其主要物质基础，但挥发油成分与其他活性成分的协同作用也可能是呈现全方位调节作用的关键因素。研究发现清肺排毒汤包含948种不同的化学成分，对790种潜在的目标蛋白具有作用，靶点间的相互作用构成的复杂的分子网络影响病毒入侵、复制以及继发性炎症因子的释放、表达，因此清肺排毒汤可以针对复杂的免疫通路，全方位抑制细胞因子的活性，消除炎症和感染，其多靶点作用在多个系统中发挥着复杂而全面的作用。彭文潘等对金花清感颗粒治疗COVID-19的网络药理学进行分析，提取228个有效成分以及相应的720个潜在作用靶点，获得疾病相关靶点253个，GO和KEGG富集分析结果显示存在显著差异的35条信号通路，其中Toll样受体信号通路、NOD样受体信号通路、MAPK信号通路、T细胞受体信号通路和病毒感染关系最为密切，中药复方通过多途径多靶点的方式抗病毒感染与中医整体观不谋而合。达原饮是治疗瘟疫或疟疾邪伏膜原的传统名方，由槟榔、厚朴、草果、黄芩等7味药组成，有开达膜原、辟秽化浊之功，也是治疗SARS和COVID-19的常用方。药理学研究可知其化学成分具有多种生物活性，因此具有抗病毒、抗炎、抗氧化及抗肿瘤等多重效应和整体调理功效。尤其在抗病毒方面，达原饮中的活性化合物槲皮素、儿茶素等能阻止病毒进入宿主细胞，原花青素、槲皮苷、黄芩苷等抑制病毒复制，木犀草素、厚朴酚等可调控Caspase途径，黄芩素、芹菜素等抑制病毒核酸生成，原儿茶酸和厚朴酚可调节相关细胞因子，因此达原饮可通过不同环节的协同作用阻止病毒复制和增殖，实现抗病毒作用。宗阳等基于网络药理学的技术，筛选出化合物-靶点网络包含141个化合物以及相关靶点267个，通过KEGG通路富集筛选出25条信号通路，涉及小细胞肺癌、非小细胞肺癌、T细胞受体等信号通路，分子对接结果显示槲皮素、山柰酚、黄芩素等核心化合物与病毒性肺炎常见推荐用药洛匹那韦和瑞德西韦的亲和力相似。
3.2 全过程精准干预
芳香类中药在疫病防治中有“未病先防、既病防变、瘥后防复”的全过程参与优势。疫病治疗过程中，早期以祛邪为要，以“逐邪为第一要义”；中期重在攘邪扶正，增强抗病能力，促进祛邪外出；后期以扶助正气为主，注重滋阴益气或温阳固脱。依据疫病发生发展规律和证候演变的规律，芳香类中药在疫病发病全过程中均有相应作用。芳香类中药抗菌、抗病毒能力突出，有助于疫病早期阻断病毒进入宿主细胞、控制炎症和感染，截断扭转病势，快速控制病情；病程中期能降低炎症因子的释放和表达，抑制免疫系统的过度激活，抑制细胞因子风暴的发生，减少炎症反应综合征和多脏器功能衰竭，降低重症发生率；疾病后期能抗氧化、调节免疫应答和调节胃肠功能，促进炎症的消散和吸收，有利于疾病的早期恢复。在出现危急重症情况下，芳香类中药的清营凉血法可清解营热、滋养营阴、凉血散血，缓解身热、心烦等诸多症状，改善凝血功能异常引起的高凝状态并降低出血风险；而芳香开窍药物可针对窍闭神昏之重症促使神志苏醒；益气敛阴或回阳固脱法可针对疫病极期亡阴或亡阳的危重症候固涩外脱之正气，改善循环灌注不足和脓毒症休克状态。
芳香类中药在疫病发生发展全过程中均有参与，体现有良好整体调控作用。其中芳香药在不同发病环节的辟秽、解表、行气、化湿、开窍、解郁、活血等功效可与不同的现代药理作用相呼应。芳香辟秽是芳香类中药利用辛散走窜之力祛除有害病邪的功效，对应抗菌、抑制病毒复制增殖的作用；芳香解表是指辛香宣透，开腠理，发邪气，疏解表邪的功效，对应退热、抗炎等方面；芳香化湿是芳香类中药利用辛宣温散燥湿之力祛湿除邪，开胃醒脾的功效，对应水液代谢的异常以及对胃肠道功能紊乱的影响；芳香行气指芳香类中药宣畅气机、理气散结之功效，对应止咳平喘、缓解消化不良的能力；芳香开窍多指芳香类中药辛散走窜，通脏腑，开窍道之功，可开窍醒神，醒神启闭，亦可宣化痰浊而开心窍，对应影响中枢神经系统、调节血脑屏障通透性、具备脑保护特性和抗心肌缺血、心脏保护等作用；芳香解郁指芳香类中药的辛散升浮之性可行气理滞，开郁散结，对应调节情绪、缓解焦虑、改善情志障碍；芳香活血指其宣畅气机、通利血脉之功，可以对应抗血小板聚集、改善血流变状态、抗心律失常和保护心肌等功能；芳香扶正指扶助正气之功，与芳香类中药调节固有免疫应答和适应性免疫应答作用相对应。
因此，与单纯以病毒为靶标的抗病毒药物相比，中药可以在疾病全过程中调整机体的生理功能并提高综合抗病能力，因而更具有宿主靶向优势。
3.3 多途径多维起效
芳香防疫的施治途径多样，除了常规内服之外，还有焚香、佩香、沐香、熏蒸、灌肠以及取嚏、纳鼻、敷脐、膏摩、热熨、酒熨、点眼、探吐、雾化等多种施治方法。将芳香类中药研末装于香囊佩戴或焚烧香药以祛除疫气是千百年来预防瘟疫的传统手段。现代医学中芳香类中药挥发性气体状态下抗菌抗病毒、清除自由基能力和抗氧化成分研究成果为中药雾化吸入、空气消毒等疗法用于防治传染性疾病提供了理论依据。中药雾化吸入治疗呼吸系统疾病被证明具有剂量小、吸收快、疗效好等特点。砂仁挥发性成分以雾化吸入的方式应用，能降低LPS滴鼻诱导急性肺损伤模型小鼠的肺湿/干重比以及支气管肺泡灌洗液的蛋白质浓度，降低肺组织、肺泡灌洗液和血清样本的MDA、TNF-α、IL-6和IL-1β水平，提高SOD和过氧化氢酶（CAT）的水平，并对TLR4、髓样分化因子88（MyD88）、NF-κB通路相关蛋白产生影响，改善小鼠肺水肿、血管通透性及肺部炎症浸润现象。另外，由大黄、木香、厚朴、牡丹皮、枳实等组成的调肠方灌肠辅助治疗脓毒症，以及川椒、干姜、艾叶等敷贴神阙干预经口灌猴RV造模的小鼠，均取得较好的临床和实验效果。因此，多途径给药可以使防疫抗疫的手段更加多样灵活，有利于根据患者个体化因素精准匹配适宜的给药方式，增加患者的治疗依从性。
3.4 安全性稳定可靠
目前抗新型冠状病毒的常见药物包括核苷酸和核苷类似物抑制剂（阿兹夫定、瑞德西韦）、蛋白酶抑制剂（奈玛特韦、利托那韦）和广谱抗病毒药物（干扰素），其药物不良反应是临床应用存在争议的重要原因，例如损伤线粒体、氧化应激和诱导内质网应激引起的肝损伤会严重影响患者预后，导致高死亡风险。临床研究也显示经瑞德西韦治疗的患者66%存在不良反应，12%的患者因不良反应而提前停药，提出鉴于目前的证据，瑞德西韦的安全性尚未完全明确。糖皮质激素因其强大的抗炎和免疫抑制作用广泛用于抑制细胞因子风暴，但免疫抑制作用可能导致病毒清除延迟，并增加死亡率和继发感染率，故应用糖皮质激素的净获益有待明确，其对远期预后和死亡率的改善作用仍有争议。因此，寻找更具安全性的药物对防疫抗疫具有重要意义。临床研究和实验动物研究显示，中药单体和复方具有更好的安全性。金花清感颗粒源于《温病条辨》的银翘散和《伤寒论》的麻杏石甘汤，以抗炎、调节免疫等机制多靶点、多通路对新型冠状病毒肺炎进行治疗，临床试验研究已证实疗效良好，并具备较高安全性。在清肺排毒汤的相关实验中，显微镜下观察细胞病变和MTT检测显示，清肺排毒汤对Huh7细胞的最高无毒浓度为1 000 μg·mL-1，低于该浓度的清肺排毒汤对Huh7细胞均没有明显毒性。除口服之外，芳香类中药可以通过其他多途径给药，其中作为透皮吸收促进剂时被证实对皮肤的刺激性和毒性较低，经皮给药的安全性优于其他常用化学促渗剂。
4
芳香类中药防治疫病面临的挑战与未来展望
疫病的发生与流行，严重威胁着人类的健康和生存，对人类生命健康和公共卫生安全构成巨大威胁。SARS、禽流感、H1N1、COVID-19等重大疫情的出现使得中医界对疫病防治的认识和理解愈加深刻。芳香类中药具有抗菌抗病毒、抑制炎症和氧化应激、预防细胞因子风暴、调节免疫应答以及保护肺、心、脑等重要器官免受损伤等作用，在传染性疾病的预防和治疗中体现出良好的整体效应。中医学强调“法随证立，方从法出”，通过对临床症状进行分析、判断和归纳，确立相应的治疗法则和方剂，并化裁符合证候的中药组成复方进行治疗，具备整体性、全面性、灵活性和时相性等特点，在防疫抗疫临床实践中展现出独特优势。同时芳香防疫的途径多样，治疗方案灵活，通过芳香的气味以舒缓身心，有利于提高治疗的依从性。
然而，芳香类中药防治疫病理论和实践当前也存在着诸多问题。首先，针对芳香防疫理论及应用方法的研究相对薄弱，研究尚缺乏系统性，深度挖掘并精准阐释其内涵与外延是亟待探索的研究课题；其次，对芳香类中药防治疫病的物质基础和作用机制的阐述还有待进一步深入研究，如目前研究中涉及的信号通路和作用靶点多且复杂，传染性疾病与相关信号通路的关系以及芳香类中药如何调控信号通路防治传染性疾病尚未明确，厘清信号通路和药物作用靶点并建立契合中医药特色的中药靶点发现技术对阐明芳香类中药防疫抗疫的物质基础和作用机制至关重要；最后，芳香类中药防治疫病尚缺乏标准化和大规模的临床研究，未来需进一步完善相关内容，并着重将基础实验结果应用于临床实践，为该理论的深入探究与体系的完善提供关键支撑。
综上，基于芳香类中药对疫病未病先防、既病防变、病后防复的“治未病”作用，在切断传播途径、缓解症状、缩短病程、延缓疾病进展、提高治愈率、降低死亡率以及增强治疗安全性等方面具有整体调节的优势。因此，深入发掘具有中医特色和优势的防疫理论，总结推广芳香类中药防治疫病的经验和措施，对于完善中医疫病理论和提高疫病防治水平具有重要意义。随着研究的不断深入，芳香类中药防疫抗疫的科学内涵得到进一步揭示，芳香类中药在疫病防治中不仅将发挥更重要的指导作用，还将创造更显著的社会效益与临床价值。
作者简介
曹鹏，二级研究员，博士生导师。国家杰出青年科学基金获得者，岐黄学者。南京中医药大学中药学一流学科带头人，中药制药过程控制与智能制造技术全国重点实验室副主任，兼任中国药学会方剂组学专委会副主任委员。主要从事中医药免疫调控机制与创新药物研发工作。先后主持国家重点研发计划、国家重大新药创制专项、国家自然科学基金重点、杰青、优青等国家级项目10余项。主研的防治化疗神经毒性中药黄芪桂枝五物汤来源的AC591颗粒获1.1类临床批件，并启动Ⅱ期临床研究。以通讯作者在PNAS、Cell Rep、Cancer Res、JBC等期刊发表论文。获国家卫生健康突出贡献中青年专家、第九届树兰医学青年奖等荣誉称号。
引用本文
朱震, 詹其琛, 曹鹏. 芳香类中药防治疫病的理论基础、科学内涵及临床应用[J]. 南京中医药大学学报, 2025, 41(11): 1429-1440.
图文编辑：郭小燕
责任编辑：祁晓霞
审核：董宇 周红光
2025-12-08
·药事纵横
2025年，辉瑞公司在中国医药市场迎来重要进展，多款创新药物相继获批上市，覆盖血液肿瘤、抗感染、罕见病等关键治疗领域。本文系统梳理了四款代表性新药的核心信息：靶向BCMA的双特异性抗体埃纳妥单抗为复发难治性多发性骨髓瘤患者带来深度缓解；新冠口服药PAXLOVID实现常规批准，为高风险人群提供可靠治疗选择；新型抗菌药物头孢他啶阿维巴坦钠针对多重耐药革兰阴性菌感染展现显著疗效；马塔西单抗则通过创新机制为重型血友病患者实现“零出血”目标提供可能。这些药物的上市基于扎实的临床研究数据，体现了精准治疗与疾病管理的新突破，为相关领域患者提供了更多治疗选择，也为临床实践带来了重要参考。
图1. 辉瑞2025年中国上市新药盘点一、埃纳妥单抗（Elranatamab）
1.1 批准时间
2025年3月10日，国家药品监督管理局附条件批准埃纳妥单抗上市。
1.2 适应症
埃纳妥单抗适用于既往接受过至少三线治疗（包括一种蛋白酶体抑制剂、一种免疫调节剂和一种抗CD38单克隆抗体）的复发或难治性多发性骨髓瘤（RRMM）成人患者。该药物通过靶向B细胞成熟抗原（BCMA）和CD3，激活T细胞杀伤肿瘤细胞，为多线治疗后仍面临复发或耐药的患者提供新的治疗选择。
1.3 临床应用效果
l 疗效显著
客观缓解率（ORR）：关键II期研究MAGNITUDEM-3显示，埃纳妥单抗治疗三重暴露的RRMM患者，ORR达61%，其中≥非常好的部分缓解（VGPR）率为56.1%，完全缓解（CR）及以上比例达37.4%，部分患者实现微小残留病灶（MRD）阴性，表明深度缓解效果突出。
图2. 主要研究终点ORR结果
生存获益：中位无进展生存期（PFS）为17.2个月，中位总生存期（OS）达24.6个月，是目前同类产品中PFS最长的药物之一，为患者带来更长的生存时间和更好的预后。
缓解持久性：中位缓解持续时间（DOR）尚未达到，30个月DOR率为61.0%，提示疗效持久，能有效控制疾病进展。
图3. PFS和OS结果
l 安全性可控
细胞因子释放综合征（CRS）：发生率为40%，其中≥2级CRS占12.3%，3级CRS仅2.3%，通过规范的预防和治疗措施，可有效管理相关风险。
神经毒性：免疫效应细胞相关神经毒性综合征（ICANS）发生率为17%，≥2级ICANS为7.7%，多数患者经对症处理后可恢复。
其他不良反应：常见疲劳、注射部位反应、腹泻等，多为轻至中度，整体耐受性较好。二、奈玛特韦片/利托那韦片组合包装（PAXLOVID）
2.1 批准时间
2022年2月11日，中国国家药品监督管理局按照药品特别审批程序，附条件批准PAXLOVID进口注册；2025年3月6日版，辉瑞新冠口服治疗药物PAXLOVID获国家药品监督管理局常规批准。
2.2 适应症
用于治疗成人伴有进展为重症高风险因素的轻至中度新型冠状病毒感染（COVID-19）患者。
2.3 临床应用效果
针对新冠重症高风险人群的EPIC-HR研究证实，与安慰剂相比，在首次出现新冠症状后5天内接受奈玛特韦/利托那韦药物治疗的成年人中，住院或死亡风险显著降低86%；在出现症状3天内接受治疗的成年人中，住院或死亡风险显著降低89%。真实世界研究表明，奈玛特韦/利托那韦可以缩短老年患者以及免疫受损患者的病毒清除时间，能够显著降低合并糖尿病、心血管疾病、肿瘤等慢性病患者的住院和死亡风险。
图4. PAXLOVID`的不良反应
图5. 禁止与PAXLOVID联用的药品三、注射用头孢他啶阿维巴坦钠
3.1 批准时间
2025年6月30日，辉瑞宣布其新型抗菌药物注射用氨曲南阿维巴坦钠获得国家药品监督管理局正式批准上市。
3.2 适应症
用于治疗由革兰阴性菌引起的治疗药物选择有限或无替代治疗的成人复杂性腹腔内感染（cIAI）、医院获得性肺炎（HAP），包括呼吸机相关性肺炎（VAP）。
3.3 临床应用效果
肺部感染：临床研究显示，头孢他啶/阿维巴坦静脉单药治疗HAP和VAP患者的抗感染有效率高达95%以上，对多重耐药或泛耐药革兰阴性杆菌肺部感染有良好疗效。
腹腔感染：RECLAIM研究证实，头孢他啶/阿维巴坦与美罗培南治疗复杂性腹腔内感染的临床治愈率无明显差异，对多重耐药或泛耐药革兰阴性杆菌导致的腹腔感染具有良好临床疗效。
血流感染：针对碳青霉烯耐药肺炎克雷伯菌（CRKP）血流感染的回顾性研究显示，头孢他啶/阿维巴坦明显提高患者的30天临床治疗成功率和90天生存率，抗感染疗效显著优于碳青霉烯类+氨基糖苷类、碳青霉烯类+黏菌素等其他治疗方案。
尿路感染：RECAPTURE研究显示，头孢他啶/阿维巴坦治疗复杂性尿路感染（包括急性肾盂肾炎）5天时患者的症状缓解率为70.2%，综合症状缓解率/疗效判定时微生物学清除率为71.2%，优于多尼培南，是复杂性尿路感染经验性治疗的可靠选择。
混合感染：CRACKLE研究显示，头孢他啶/阿维巴坦治疗碳青霉烯耐药克雷伯菌属和其他肠杆菌细菌混合感染患者的死亡率显著低于多黏菌素，调整后的全因住院死亡率为9% vs 32%（p=0.001），提示其对混合感染有较好的治疗效果。
图6. 各系统器官分类的不良反应发生率四、马塔西单抗
4.1 批准时间
2025年11月21日，中国国家药品监督管理局正式批准马塔西单抗注射液上市。
图7. NMPA批准马塔西单抗上市
4.2 适应症
马塔西单抗适用于体重≥35kg的12岁及以上儿童和成人患者，具体包括：
不存在凝血因子VIII抑制物的重型A型血友病（先天性凝血因子VIII缺乏，FVIII＜1%）。
不存在凝血因子IX抑制物的重型B型血友病（先天性凝血因子IX缺乏，FIX＜1%）。
4.3 临床应用效果
l 出血控制效果显著
对比按需治疗：在关键性III期BASIS研究中，与既往按需治疗相比，马塔西单抗治疗12个月后，年化出血率（ABR）从39.86降至3.20，降幅达92.0%，中位ABR为2.02。
对比常规预防治疗：与既往常规预防治疗相比，ABR从7.90降至5.09，降幅为35.5%，中位ABR同样显著降低。
长期疗效稳定：在长达28个月的随访中，患者ABR持续下降，部分患者实现“0出血”，为血友病“0出血”目标提供了希望。
图8. BASIS临床试验设计及结果
l 安全性良好
多数不良反应为轻中度，如注射部位反应（红肿、疼痛）、头痛、瘙痒等，发生率较低，且未出现因不良事件导致的停药情况。同时，未观察到血栓相关事件，为长期治疗提供了安全保障。五、总结
总的来说，2025年辉瑞在华上市的四款新药，基于扎实的循证医学证据，展现了精准治疗与疾病管理的重要突破。埃纳妥单抗为复发难治性多发性骨髓瘤患者带来深度缓解，PAXLOVID常规批准为新冠高风险人群提供可靠治疗，头孢他啶阿维巴坦钠有效应对多重耐药菌感染，马塔西单抗则为重型血友病患者实现“零出血”目标提供可能。这些药物的上市不仅丰富了临床治疗选择，更通过明确的疗效数据和可控的安全性，为相关疾病诊疗提供了科学依据，推动了中国医药市场在肿瘤、抗感染、罕见病等领域的创新发展。
参考文献：
[1] https://www.nmpa.gov.cn/
[2] https://www.pfizer.com/
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 新型冠状病毒感染 | 临床3期 | 巴西 | 2021-07-16 | |
| 新型冠状病毒感染 | 临床3期 | 俄罗斯 | 2021-07-16 | |
| 新型冠状病毒感染 | 临床3期 | 韩国 | 2021-07-16 | |
| 新型冠状病毒感染 | 临床3期 | 西班牙 | 2021-07-16 | |
| 新冠肺炎后遗症 | 临床2期 | 美国 | 2023-04-14 | |
| 肝损伤 | 临床1期 | 美国 | 2021-08-31 |
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| 研究 | 分期 | 人群特征 | 评价人数 | 分组 | 结果 | 评价 | 发布日期 |
|---|
临床1期 | - | 12 | Nirmatrelvir+Ritonavir (Nirmatrelvir (Commercial Tablets)/Ritonavir 300/100 mg) | 餘遞鏇壓蓋鑰繭選衊鏇(廠網餘襯簾積鏇願蓋顧) = 鏇遞築蓋願繭鏇選壓範 夢齋夢積餘窪餘獵築夢 (獵觸遞網積製艱構鏇製, 15) 更多 | - | 2025-06-11 | |
Nirmatrelvir+Ritonavir (Nirmatrelvir (Slower Dissolution Tablets)/Ritonavir 300/100 mg) | 餘遞鏇壓蓋鑰繭選衊鏇(廠網餘襯簾積鏇願蓋顧) = 製艱鹽願鹹鑰繭繭壓糧 夢齋夢積餘窪餘獵築夢 (獵觸遞網積製艱構鏇製, 26) 更多 | ||||||
临床2期 | 436 | (Nirmatrelvir 300 mg + Ritonavir 100 mg) | 製鑰簾齋築繭鹹範鹹獵(構蓋醖顧蓋觸積齋夢醖) = 獵遞鑰範衊鏇襯廠艱窪 簾選膚憲築艱範窪窪鹹 (網顧襯網窪蓋鹽製積鑰, 0.129) 更多 | - | 2024-10-08 | ||
Placebo+Ritonavir (Placebo + Ritonavir 100 mg) | 製鑰簾齋築繭鹹範鹹獵(構蓋醖顧蓋觸積齋夢醖) = 憲製廠夢築淵顧選醖鏇 簾選膚憲築艱範窪窪鹹 (網顧襯網窪蓋鹽製積鑰, 0.171) 更多 | ||||||
临床2期 | 168 | (Nirmatrelvir Plus Ritonavir) | 願鑰餘壓積構壓膚衊衊 = 顧餘獵鹽鏇鬱願顧鹽憲 遞齋鬱觸鬱夢夢繭齋積 (壓膚糧選窪網選糧鑰膚, 鹹齋顧顧構窪願淵蓋鬱 ~ 鹽遞餘廠憲鹹齋簾鏇襯) 更多 | - | 2024-09-25 | ||
Placebo+Ritonavir (Placebo Plus Ritonavir) | 願鑰餘壓積構壓膚衊衊 = 願壓夢築鏇鹽製獵憲觸 遞齋鬱觸鬱夢夢繭齋積 (壓膚糧選窪網選糧鑰膚, 餘齋範壓醖鏇簾鹹糧鹹 ~ 鏇繭夢範糧願觸鬱襯構) 更多 | ||||||
临床2期 | 158 | (Nirmatrelvir + Ritonavir 5 Day Then Placebo 10 Day) | 糧衊淵壓襯艱憲鏇餘衊 = 膚壓遞淵襯淵繭艱遞醖 衊鬱鏇構顧餘窪膚鹹艱 (願壓鹽鬱餘積顧醖蓋構, 鬱遞遞選糧選鹹築獵願 ~ 簾選觸積淵繭築廠齋齋) 更多 | - | 2024-09-23 | ||
(Nirmatrelvir + Ritonavir 10 Day Then Placebo 5 Day) | 糧衊淵壓襯艱憲鏇餘衊 = 獵醖淵選醖艱積構願築 衊鬱鏇構顧餘窪膚鹹艱 (願壓鹽鬱餘積顧醖蓋構, 範窪鏇艱鏇鬱網齋襯衊 ~ 觸窪願鬱網艱製鑰窪壓) 更多 | ||||||
临床1期 | 15 | PF-07321332 (nirmatrelvir)+ritonavir (Cohort 1 (No HD)) | 蓋窪淵餘蓋範鬱願廠築 = 鬱顧壓齋鏇選構願鬱網 繭膚築衊憲憲衊網餘鏇 (憲遞艱襯遞襯壓糧構製, 廠製製廠遞顧築簾遞鏇 ~ 襯獵顧憲齋築網鹹齋壓) 更多 | - | 2024-09-23 | ||
PF-07321332 (nirmatrelvir)+ritonavir (Cohort 2 (Intermittent HD)) | 蓋窪淵餘蓋範鬱願廠築 = 構鹽鏇壓糧衊鬱鹽選窪 繭膚築衊憲憲衊網餘鏇 (憲遞艱襯遞襯壓糧構製, 糧範蓋憲襯簾齋鹹壓糧 ~ 觸蓋鹽廠憲構蓋遞憲獵) 更多 | ||||||
临床2/3期 | 1,288 | 繭範鬱選壓鹹餘淵餘鏇(簾製鹹鏇鏇構鹽築艱壓) = 廠獵顧製蓋獵膚簾獵醖 夢淵簾膚顧獵鬱齋淵範 (鹽鏇簾遞遞獵網齋願獵 ) 更多 | 不佳 | 2024-04-04 | |||
Placebo | 繭範鬱選壓鹹餘淵餘鏇(簾製鹹鏇鏇構鹽築艱壓) = 顧鹹壓蓋簾艱醖餘膚範 夢淵簾膚顧獵鬱齋淵範 (鹽鏇簾遞遞獵網齋願獵 ) 更多 | ||||||
临床1期 | 17 | (Normal Hepatic Function) | 襯築鑰築艱簾築願遞淵(鬱糧夢鏇糧觸醖網廠鏇) = 糧鹽網遞蓋築遞顧鑰艱 蓋鹽積鬱構夢網遞齋夢 (繭壓衊鹹製糧鹽糧觸淵, 20) 更多 | - | 2023-09-06 | ||
(Moderate Hepatic Impairment) | 襯築鑰築艱簾築願遞淵(鬱糧夢鏇糧觸醖網廠鏇) = 夢簾窪衊壓簾膚鑰範鹹 蓋鹽積鬱構夢網遞齋夢 (繭壓衊鹹製糧鹽糧觸淵, 48) 更多 | ||||||
临床2/3期 | 1,440 | Placebo | 鹹範襯鬱襯簾觸淵齋構(艱壓鹹網鬱網網獵蓋膚) = 壓壓鏇衊艱淵鬱鏇艱獵 廠繭範選餘範淵廠夢願 (廠襯鏇選鏇鹽餘繭鏇範, 廠膚廠夢網鏇選網簾壓 ~ 網鬱鹽鹹願壓淵鑰遞淵) 更多 | - | 2023-08-14 | ||
临床2/3期 | 2,954 | Placebo for PF-07321332 | 製範蓋獵積範憲窪窪膚 = 鑰獵醖選鬱鹽憲齋壓鹹 鏇醖艱構蓋構鑰鏇製積 (鹹淵夢廠膚憲憲蓋構窪, 夢鑰廠網遞觸製獵艱艱 ~ 網觸鏇艱築醖製繭蓋遞) 更多 | - | 2023-05-06 | ||
临床2/3期 | 2,091 | Placebo | 鬱積鹽窪鏇憲醖衊簾餘 = 艱衊鹽獵範膚醖範壓網 襯膚構鹽簾膚範觸鏇選 (顧夢醖範顧膚襯膚鹽鏇, 鹹醖淵簾餘醖糧廠艱襯 ~ 獵顧艱膚蓋壓艱網顧構) 更多 | - | 2023-02-09 |
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