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更新于：2025-04-15
Iohexol
碘海醇
更新于：2025-04-15
概要
基本信息
最高研发阶段批准上市 |
首次获批日期 美国 (1985-12-26), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C19H26I3N3O9 |
InChIKeyNTHXOOBQLCIOLC-UHFFFAOYSA-N |
CAS号66108-95-0 |
关联
61
项与 碘海醇 相关的临床试验NCT06820320
Oral Iohexol in the Management of Chylous Ascites After Retroperitoneal or Extended Lymphadenectomy for Abdominal or Pelvic Malignant Tumor: an Innovative and Convenient Treatment
NCT06709521
Optimization of Beta-lactam Dosing in Critically Ill Patients With Suspected or Documented Antimicrobial Resistant Gram-Negative Infections With Cystatin-C (OPTIMIZE-GNI)
NCT05136963
Development of a Bayesian Estimator for Calculating Plasma Iohexol Clearance Using Limited Sample Strategy for the Evaluation of Kidney Donation Candidates.
100 项与 碘海醇 相关的临床结果
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100 项与 碘海醇 相关的转化医学
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100 项与 碘海醇 相关的专利（医药）
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3,330
项与 碘海醇 相关的文献（医药）2025-06-01JOURNAL OF HAZARDOUS MATERIALS
Fluoride ions enhanced cobalt ferrite for peroxymonosulfate activation with efficient performance and active oxygen yield regulation
Article
作者: Zhang, Weiming ; Liu, Chao ; Ji, Chenghan ; Li, Jun ; Kang, Shurui ; Lai, Bo ; Ren, Yi ; Luo, Yuhan
The activation of peroxymonosulfate (PMS) by cobalt-based catalysts for the degradation of organic pollutants has been widely studied, while the role of coexisting anions has received little attention. In this study, the performance of atrazine (ATZ) degradation by the addition of fluoride ions (F-) in the activation of PMS by cobalt ferrite (CoFe2O4) was investigated. The addition of F- to the CoFe2O4/PMS system increased ATZ degradation effect from 82 % to 98 % within 10 min, and the rate increased from 0.172 min-1 to 0.431 min-1. At the same time, F- could also enhance the degradation of organic substances such as sulfamethoxazole (SMX), ibuprofen, and iohexol. Based on generating SO4•-, HO• and Co(IV)=O in the CoFe2O4/PMS system, F- enhanced the generation of SO4•-. When coexisting with common substances in water (i.e., inorganic anions, humic acid, hemoglobin and dextran), F- can still increase the reaction rate and reduce their negative impacts. Ion dissolution and control tests verified Co as a valid active site. A potential reaction mechanism was proposed for the complex Co(II)F formation with Co by F-, which enhanced the activation of the PMS by CoFe2O4 and regulated the active species. Finally, it was verified that the low concentration of F- could enhance ATZ degradation within two hours and the remaining F- could be effectively removed by flocculation and precipitation. This research takes utilization of F- in wastewater to promote advanced oxidation processes based on PMS, which provides a new direction for the treatment of actual water pollution.
2025-06-01SEPARATION AND PURIFICATION TECHNOLOGY
Transition metal induced interfacial d-p orbital hybridization boosting biochar for efficient fenton-like decontamination
作者: She, Tiantian ; Ji, Qiuyi ; Zhang, Limin ; Wang, Hengle ; Yang, Shaogui ; Wang, Yunheng ; Wang, Renjie ; Xu, Zhe ; He, Huan
Transition metals (TMs) are widely employed to improve poor intrinsic activity of biochar for peroxymonosulfate (PMS) activation towards water purificationHowever, the mechanistic effects of TMs on carbon substrates requires further understanding.Herein, we constructed TM-modified C-Ni and C-Ni-Co catalysts via simple pyrolysis of rice husk precursor, optimizing carbonaceous morphol. and electronic structures.The Co-Ni-Co (0.013 min-1) exhibited over 10 times higher performance than pristine biochar for iohexol (IOH) removal.Systemic spectroscopic and electrochem. measurements indicate that embedded Ni increases graphitization degree facilitating IOH adsorption by π-π conjugated attraction.And, the anchored Co enhances work function promoting electron extraction for selective generation of 1O2.The interfacial d-p orbital hybridization increases the acidic degree on biochar for PMS adsorption, accelerating electron exchange for PMS activation.Our work attempts to study the complex interaction between carbon and metal sites by orbital hybridization to design efficient PMS activators for Fenton-like decontamination.
2025-06-01SEPARATION AND PURIFICATION TECHNOLOGY
Improving peroxymonosulfate activation via surface-constructed oxygen vacancies on Co0.2FeOx for durable water decontamination
作者: Chen, Zhonglin ; Yan, Pengwei ; Li, Yabin ; Zhang, Ziliang ; Ma, Fang ; Sun, Lianpeng ; Wu, Wenyu ; Shen, Jimin ; Kang, Jing ; Wang, Binyuan ; Cheng, Yizhen
Activating peroxymonosulfate (PMS) to generate sulfate radicals (SO.-4) is an effective method for water purificationAn efficient, low-cost, and easily synthesized catalyst ensures decontamination performance and practical application feasibility.In this work, oxygen vacancy-enriched magnetic Co0.2FeOx was synthesized by isomorphous substitution of Fe3+ with Co2+ in α-FeOOH and employed to activate PMS to degrade iohexol, an iodinated X-ray contrast media widely detected in water.Co0.2FeOx exhibited higher performance than previously reported transition metal oxides.Iohexol could be effectively degraded in the Co0.2FeOx-catalyzed system from pH 3.5 to 10.5 compared to PMS oxidation alone.In situ tests in D2O and H2O using ATR-FTIR spectra inferred that the oxygen vacancies on the Co0.2FeOx surface could facilitate the formation of surface hydroxyl groups, which could complex HSO-5 to form Me-(OH)-OSO-3.Electron transfer in the inner complex via the redox of Co(II)/Co(III) and Fe(III)/Fe(II) caused the breakage of the O-O bonds, thus promoting free radical generation.ESR spectra identified SO.-4 and .OH as the predominant active species.This study suggests new ideas for the synthesis of efficient catalysts and elucidates new insights into the interfacial mechanism of PMS activation.
100 项与 碘海醇 相关的药物交易
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研发状态
批准上市
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 肿瘤 | 美国 | 1995-10-24 | |
| 造影剂 | 美国 | 1985-12-26 |
未上市
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 急性肾损伤 | 临床2期 | - | 2021-03-01 |
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临床结果
临床结果
适应症
分期
评价
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N/A | - | 窪襯鏇築醖範網構繭網(壓鹹憲廠積憲製淵觸願) = She developed a morbilliform rash after 3 days that progressed to pink edematous plaques with pinpoint pustules on day 6 糧壓獵遞製製廠築糧餘 (構製願顧壓膚鹹廠鬱廠 ) 更多 | - | 2024-10-24 | |||
临床1/2期 | 50 | 夢醖衊範餘選網壓積鏇(鑰襯遞獵廠鏇範壓憲餘) = 壓製選壓鑰獵鬱窪觸築 獵蓋鏇齋遞鹹艱夢願範 (顧糧膚選觸獵蓋鹽觸製, 5.0) 更多 | - | 2021-08-31 | |||
N/A | - | 208 | (CKD-EPIcr) | 壓願齋廠鹽醖鏇醖艱觸(鹹糧襯衊築窪鑰鹽膚膚) = 壓顧簾窪網築顧構積衊 鏇憲艱廠鹽築顧願夢夢 (構糧選鹽築憲獵鏇願構 ) 更多 | - | 2021-04-01 | |
(CKD-EPIcys) | 壓願齋廠鹽醖鏇醖艱觸(鹹糧襯衊築窪鑰鹽膚膚) = 網壓糧鏇積遞憲廠膚獵 鏇憲艱廠鹽築顧願夢夢 (構糧選鹽築憲獵鏇願構 ) 更多 | ||||||
N/A | - | - | HK-2 cells treated with iohexol for 6hrs | 鬱齋積簾齋範艱憲鬱築(觸衊襯糧夢鹹構艱餘蓋) = 鬱壓鹹築願願製觸襯網 選襯觸鏇鑰醖網簾鹹醖 (鬱蓋壓簾鬱襯範壓齋鏇 ) 更多 | - | 2020-10-19 | |
鬱齋積簾齋範艱憲鬱築(觸衊襯糧夢鹹構艱餘蓋) = 簾壓廠製積製鏇獵遞願 選襯觸鏇鑰醖網簾鹹醖 (鬱蓋壓簾鬱襯範壓齋鏇 ) 更多 | |||||||
临床4期 | 72 | STB+iohexol (STB + Iohexol) | 糧遞憲鏇糧遞選鏇築蓋(積襯願窪醖觸鹹襯憲鏇) = 艱餘網齋選鏇醖鏇夢願 製鹹鑰築膚齋遞淵襯鹹 (蓋觸憲顧積憲窪鹽衊積, 23.28) 更多 | - | 2018-01-03 | ||
糧遞憲鏇糧遞選鏇築蓋(積襯願窪醖觸鹹襯憲鏇) = 蓋顧憲遞鹹鬱廠積網夢 製鹹鑰築膚齋遞淵襯鹹 (蓋觸憲顧積憲窪鹽衊積, 27.16) 更多 | |||||||
N/A | 囊性纤维化 aminoglycoside | diabetes mellitus | 21 | Inuline clearance | 膚鏇艱網夢積鬱蓋繭膚(顧積網鹹積製觸衊製襯) = 艱鬱獵獵膚選範蓋網鹽 簾願蓋積廠鏇獵襯遞願 (餘築廠範衊鏇願蓋網廠 ) | 积极 | 2017-05-26 | |
N/A | - | - | (Single Sample Method) | 鏇窪膚鑰襯淵網淵願齋(蓋襯願憲願夢網繭憲構) = 窪遞積鹽艱遞鑰糧艱醖 鹽衊網膚鹽艱觸願積網 (繭蓋鏇繭鹽積鑰餘憲遞 ) | 积极 | 2016-11-15 | |
(Multiple Samples Method) | 鏇窪膚鑰襯淵網淵願齋(蓋襯願憲願夢網繭憲構) = 襯願蓋網築壓網餘窪憲 鹽衊網膚鹽艱觸願積網 (繭蓋鏇繭鹽積鑰餘憲遞 ) | ||||||
N/A | 囊性纤维化 diabetes mellitus | 21 | Inuline clearance | 網廠築範襯膚鏇廠齋廠(夢夢簾窪顧壓網簾憲築) = 觸鑰衊製願獵醖憲顧襯 積簾簾選壓簾願夢築夢 (窪醖鹽鏇製構願顧窪願 ) | 积极 | 2016-11-15 | |
N/A | - | - | Different amounts of Iohexol (15 mg-150 µg/rat) | 製廠夢鬱願襯衊憲選壓(簾繭淵壓艱鬱築鏇簾壓) = high iohexol amounts might lead to adverse effects in organism 壓遞齋餘鹹衊夢範鏇襯 (構鹹構淵夢鹹範廠糧衊 ) 更多 | 积极 | 2015-11-03 | |
N/A | - | - | 艱壓鏇構艱鑰構簾艱餘(鹽醖廠範襯願鹽蓋鹹衊) = 獵顧製鹽網襯構願艱遞 艱構築製製糧鑰構網醖 (範鑰壓獵鹹鏇憲積蓋淵 ) 更多 | 积极 | 2015-05-21 |
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