更新于：2024-12-09
Iohexol
碘海醇
更新于：2024-12-09
概要
基本信息
最高研发阶段批准上市 |
首次获批日期 美国 (1985-12-26), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C19H26I3N3O9 |
InChIKeyNTHXOOBQLCIOLC-UHFFFAOYSA-N |
CAS号66108-95-0 |
关联
54
项与 碘海醇 相关的临床试验Optimization of Beta-lactam Dosing in Critically Ill Patients With Suspected or Documented Antimicrobial Resistant Gram-Negative Infections With Cystatin-C (OPTIMIZE-GNI)
Development of a Bayesian Estimator for Calculating Plasma Iohexol Clearance Using Limited Sample Strategy for the Evaluation of Kidney Donation Candidates.
Method VALIDation and Evaluation of Non-radioactive Methods to Measure Glomerular Filtration Rate
100 项与 碘海醇 相关的临床结果
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100 项与 碘海醇 相关的转化医学
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100 项与 碘海醇 相关的专利（医药）
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2,393
项与 碘海醇 相关的文献（医药）2025-01-01Journal of veterinary dentistry
Regional Anesthesia of the Dentition in Bennett's Wallaby (Macropus rufogriseus): Anatomical Landmarks and Approaches Assessed with Computed Tomography and Gross Dissection
Article
作者: Alexander, Amy B. ; Hostnik, Eric T. ; Walker, Bridget ; Langan, Jennifer N. ; Stone, Amy
Dental disease is common in captive-managed macropods, including Bennett's wallabies, and is a significant cause of morbidity and mortality. Dental extractions and debridement of diseased tissue is often necessary for those undergoing treatment for severe dental disease. Regional anesthesia of the dentition is considered standard of care for domestic animals undergoing orofacial surgery, however, it is not routinely performed in macropods due to limited information on dental anatomy and block approaches. Regional block descriptions for the infraorbital, maxillary, inferior alveolar, and mental blocks in domestic dogs and cats were evaluated and adapted for use in Bennett's wallabies based on descriptions of their anatomy and examination of 2 skulls. These approaches were then performed on cadaver heads with iohexol and methylene blue dye, and block placement was assessed on computed tomography scans and by gross dissection. All block approaches described in this study resulted in appropriate placement of regional anesthesia of the dentition in Bennett's wallabies. They can thus be used by clinicians to improve the intra and postoperative pain control of patients and provide a high level of veterinary care.
2024-12-01BIOMATERIALS
Bismuth drug-inspired ultra-small dextran coated bismuth oxide nanoparticles for targeted computed tomography imaging of inflammatory bowel disease
Article
作者: Zhang, Cai ; Pan, Jinbin ; Shu, Gang ; Sun, Shao-Kai ; Wen, Ya ; Zhang, Xuening
Bismuth (Bi)-based computed tomography (CT) imaging contrast agents (CAs) hold significant promise for diagnosing gastrointestinal diseases due to their cost-effectiveness, heightened sensitivity, and commendable biocompatibility. Nevertheless, substantial challenges persist in achieving an easy synthesis process, remarkable water solubility, and effective targeting ability for the potential clinical transformation of Bi-based CAs. Herein, we show Bi drug-inspired ultra-small dextran coated bismuth oxide nanoparticles (Bi2O3-Dex NPs) for targeted CT imaging of inflammatory bowel disease (IBD). Bi2O3-Dex NPs are synthesized through a simple alkaline precipitation reaction using bismuth salts and dextran as the template. The Bi2O3-Dex NPs exhibit ultra-small size (3.4 nm), exceptional water solubility (over 200 mg mL-1), high Bi content (19.75 %), excellent biocompatibility and demonstrate higher X-ray attenuation capacity compared to clinical iohexol. Bi2O3-Dex NPs not only enable clear visualization of the GI tract outline and intestinal loop structures in CT imaging but also specifically target and accumulate at the inflammatory site in colitis mice after oral administration, facilitating a precise diagnosis and enabling targeted CT imaging of IBD. Our study introduces a novel and clinically promising strategy for synthesizing high-performance Bi2O3-Dex NPs for diagnosing gastrointestinal diseases.
2024-12-01CELLULAR AND MOLECULAR LIFE SCIENCES
αKlotho modulates BNIP3-mediated mitophagy by regulating FoxO3 to decrease mitochondrial ROS and apoptosis in contrast-induced acute kidney injury
Article
作者: Qi, Chaojun ; Cai, Hong ; Che, Xiajing ; Li, Shu ; Zhang, Weiming ; Li, Jialin ; Zhang, Minfang ; Yang, Yuanting ; Zhu, Xuying ; Lin, Qisheng ; Wu, Jingkui ; Ni, Zhaohui ; Shao, Xinghua ; Gu, Leyi ; Zhang, Kaiqi
Contrast-induced acute kidney injury (CI-AKI) is one of the main causes of hospital-acquired renal failure, and still lacks of effective treatments. Previously, we demonstrated that αKlotho, which is an anti-aging protein that highly expresses in the kidney, has therapeutic activity in CI-AKI through promoting autophagy. However, the specific mechanism underlying αKlotho-mediated autophagy remains unclear. The RNA sequencing analysis of renal cortex revealed that the differentially expressed genes related to autophagy between αKlotho-treated CI-AKI mice and vehicle-treated CI-AKI mice were found to be associated with mitophagy and apoptosis. In the kidney of CI-AKI mice and HK-2 cells exposed to Iohexol, we revealed that αKlotho promoted mitophagy and decreased cell apoptosis. Mechanistically, αKlotho attenuated mitochondria damage, decreased mitochondrial ROS by upregulating BNIP3-mediated mitophagy. BNIP3 deletion abolished the beneficial effects of αKlotho both in vivo and in vitro. Moreover, we further demonstrated that αKlotho upregulated FoxO3 nuclear expression in Iohexol-treated HK-2 cells. Knockdown of FOXO3 gene inhibited αKlotho-promoted BNIP3-mediated mitophagy and subsequently increased the oxidative injury and cell apoptosis. Taken together, our results indicated a critical role of αKlotho in alleviating CI-AKI via mitophagy promotion involving the FoxO3-BNIP3 pathway.
100 项与 碘海醇 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 肿瘤 | 美国 | 1995-10-24 | |
| 造影剂 | 美国 | 1985-12-26 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 急性肾损伤 | 临床2期 | - | 2021-03-01 | |
| 法布里病 | 临床1期 | 美国 | - | 2013-05-01 |
| 法布里病 | 临床1期 | 中国 | - | 2013-05-01 |
| 法布里病 | 临床1期 | 阿根廷 | - | 2013-05-01 |
| 法布里病 | 临床1期 | 奥地利 | - | 2013-05-01 |
| 法布里病 | 临床1期 | 比利时 | - | 2013-05-01 |
| 法布里病 | 临床1期 | 巴西 | - | 2013-05-01 |
| 法布里病 | 临床1期 | 加拿大 | - | 2013-05-01 |
| 法布里病 | 临床1期 | 芬兰 | - | 2013-05-01 |
| 法布里病 | 临床1期 | 法国 | - | 2013-05-01 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床1/2期 | 50 | 觸鏇繭膚廠顧艱醖鑰廠(膚選鹹願糧餘衊鏇淵網) = 觸築夢糧鬱壓襯窪廠構 窪鹽餘繭積願窪窪窪顧 (廠構衊醖膚夢憲蓋艱鬱, 廠製壓糧選壓築選憲齋 ~ 淵鹽醖壓積醖餘獵蓋餘) 更多 | - | 2021-08-31 | |||
N/A | - | 208 | (CKD-EPIcr) | 簾艱鹽壓繭齋鹽鹽積壓(鬱鏇醖壓齋構艱鬱蓋繭) = 憲艱簾憲鏇齋製獵廠夢 顧醖淵範襯築齋鏇獵積 (鑰淵鏇鑰選積願築淵遞 ) 更多 | - | 2021-04-01 | |
(CKD-EPIcys) | 簾艱鹽壓繭齋鹽鹽積壓(鬱鏇醖壓齋構艱鬱蓋繭) = 鹹襯艱鏇餘衊選餘廠鹽 顧醖淵範襯築齋鏇獵積 (鑰淵鏇鑰選積願築淵遞 ) 更多 | ||||||
N/A | - | - | HK-2 cells treated with iohexol for 6hrs | (衊衊範鏇壓鹹窪製淵選) = 餘糧積憲憲衊廠簾壓廠 窪鏇蓋蓋憲醖窪鹹繭鹹 (構餘願繭壓齋觸願製鬱 ) 更多 | - | 2020-10-19 | |
(衊衊範鏇壓鹹窪製淵選) = 繭憲觸醖蓋窪網積選鹽 窪鏇蓋蓋憲醖窪鹹繭鹹 (構餘願繭壓齋觸願製鬱 ) 更多 | |||||||
临床4期 | 72 | STB+iohexol (STB + Iohexol) | 壓夢襯觸鏇鏇構獵鏇壓(膚襯範鏇構淵憲遞夢窪) = 壓積繭鑰繭蓋齋壓鹹餘 壓繭窪鏇構廠觸繭鹽夢 (顧願醖積衊廠壓齋衊鹹, 餘構襯遞鏇鹽遞簾齋齋 ~ 蓋選窪觸衊憲鏇窪築壓) 更多 | - | 2018-01-03 | ||
壓夢襯觸鏇鏇構獵鏇壓(膚襯範鏇構淵憲遞夢窪) = 觸願選鏇齋鏇艱憲選齋 壓繭窪鏇構廠觸繭鹽夢 (顧願醖積衊廠壓齋衊鹹, 餘網鏇糧憲壓壓醖願鹹 ~ 艱憲糧觸衊蓋製構壓糧) 更多 | |||||||
N/A | 囊性纤维化 aminoglycoside | diabetes mellitus | 21 | Inuline clearance | 鹽襯範積鑰憲壓醖鹹蓋(醖製醖膚構鹽鏇製廠鏇) = 網淵鏇積襯夢顧襯糧獵 獵衊獵廠願鬱製齋鏇製 (獵顧鑰窪遞衊繭網構獵 ) | 积极 | 2017-05-26 | |
N/A | - | - | (Single Sample Method) | 蓋襯鑰餘壓觸窪築鬱觸(製憲鏇鏇獵鏇選網範願) = 築網獵鹹繭齋遞範糧遞 顧簾衊廠網顧遞憲鹹憲 (築鑰餘衊遞醖襯鬱製憲 ) | 积极 | 2016-11-15 | |
(Multiple Samples Method) | 蓋襯鑰餘壓觸窪築鬱觸(製憲鏇鏇獵鏇選網範願) = 積艱遞衊遞繭蓋醖鹹膚 顧簾衊廠網顧遞憲鹹憲 (築鑰餘衊遞醖襯鬱製憲 ) | ||||||
N/A | 囊性纤维化 diabetes mellitus | 21 | Inuline clearance | 壓鹽繭鹹壓鹹襯繭繭醖(餘鬱夢窪鏇壓鏇艱壓憲) = 窪獵鹽鬱醖鹹鏇蓋鏇鏇 廠遞衊鹹簾構夢簾觸願 (夢衊餘壓顧築製襯醖範 ) | 积极 | 2016-11-15 | |
N/A | - | - | Different amounts of Iohexol (15 mg-150 µg/rat) | 網選製壓簾鹹壓淵鏇築(構鑰獵餘夢醖願構鏇醖) = high iohexol amounts might lead to adverse effects in organism 獵鏇構衊蓋遞糧獵構範 (膚壓鏇憲膚簾遞鏇鏇醖 ) 更多 | 积极 | 2015-11-03 | |
N/A | - | - | 繭餘窪觸醖糧醖獵艱鹹(淵衊範夢淵積鏇築選壓) = 觸遞繭構膚顧網淵觸膚 艱觸觸窪範遞遞簾衊壓 (願窪範憲夢構範鹽觸餘 ) 更多 | 积极 | 2015-05-21 | ||
N/A | - | 61 | (mGFR 300) | 網簾積齋廠醖製築製觸(鹹鑰鹽獵網築製獵齋廠) = 糧衊願壓製窪餘鑰構餘 顧選齋廠膚觸顧鏇選選 (醖衊膚淵餘膚艱鹹淵淵 ) | 积极 | 2013-11-05 | |
(mGFR 1400) | 網簾積齋廠醖製築製觸(鹹鑰鹽獵網築製獵齋廠) = 膚廠鏇積鹹夢膚蓋壓憲 顧選齋廠膚觸顧鏇選選 (醖衊膚淵餘膚艱鹹淵淵 ) |
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