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更新于：2026-05-07
Lixisenatide
利司那肽
更新于：2026-05-07
概要
基本信息
最高研发阶段批准上市 |
首次获批日期 欧盟 (2013-01-31), |
最高研发阶段(中国)撤市 |
特殊审评- |
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结构/序列
Sequence Code 25682
来源: *****
关联
70
项与 利司那肽 相关的临床试验NCT07173712
Regimen Transition After Short-Term Intensive Insulin Therapy in Type 2 Diabetes Mellitus Patients With Inadequate Glycemic Control on Oral Hypoglycemic Agents: A Multicenter, Open-Label, Randomized Controlled Study
Failure of oral antidiabetic drugs (OADs) is a frequent challenge in patients with type 2 diabetes mellitus (T2DM), and inadequate long-term glycemic control substantially increases the risk of diabetic complications. Short-term intensive insulin therapy (SIIT) is an established approach to mitigate glucotoxicity; however, the optimal strategy to sustain long-term glycemic benefits after SIIT in T2DM patients with OAD failure remains unclear. To address this gap, we designed a randomized controlled trial to evaluate subsequent treatment options, aiming to identify a simple and effective regimen for patients with poor glycemic control who undergo SIIT.
A total of 324 eligible patients will be enrolled. After screening, previous antidiabetic regimens will be discontinued, and patients will be randomly assigned to the SIIT- iGlarLixi group (A), the SIIT-IDegAsp group (B), or the SIIT-iGlar group (C). All patients will be hospitalized for short-term insulin pump therapy, followed by 24 weeks of treatment: group A with insulin glargine/lixisenatide, group B with insulin degludec/aspart, and group C with insulin glargine U300 plus metformin. During the extension follow-up period, patients in all groups may either continue their assigned regimen or return to their original pre-study therapy. A total of 10 clinic visits are scheduled for each patient throughout the study.
Primary endpoint is proportion of patients achieving glycosylated hemoglobin A1C <7% at 24 weeks.Secondary endpoints include proportion of patients achieving glycosylated hemoglobin A1C <6.5% at 24 weeks; differences in weight gain, hypoglycemic events among treatment groups, and differences in proportion of patients continuing the assigned regimen, glycemic control and body weight at the extension follow-up period.
A total of 324 eligible patients will be enrolled. After screening, previous antidiabetic regimens will be discontinued, and patients will be randomly assigned to the SIIT- iGlarLixi group (A), the SIIT-IDegAsp group (B), or the SIIT-iGlar group (C). All patients will be hospitalized for short-term insulin pump therapy, followed by 24 weeks of treatment: group A with insulin glargine/lixisenatide, group B with insulin degludec/aspart, and group C with insulin glargine U300 plus metformin. During the extension follow-up period, patients in all groups may either continue their assigned regimen or return to their original pre-study therapy. A total of 10 clinic visits are scheduled for each patient throughout the study.
Primary endpoint is proportion of patients achieving glycosylated hemoglobin A1C <7% at 24 weeks.Secondary endpoints include proportion of patients achieving glycosylated hemoglobin A1C <6.5% at 24 weeks; differences in weight gain, hypoglycemic events among treatment groups, and differences in proportion of patients continuing the assigned regimen, glycemic control and body weight at the extension follow-up period.
开始日期2026-03-15 |
申办/合作机构 |
NCT07117240
Efficacy of Treatment Strategies for Steroid-induced Diabetes - a Comparison of GLP-1 Receptor Agonist Plus Basal Insulin With Intensive Insulin Therapy
Glucocorticoids are commonly used in the treatment of autoimmune, inflammatory, and neoplastic diseases. Despite their therapeutic efficacy, they are associated with significant metabolic side effects. In the proposed research, the aim is to assess the metabolic efficacy and safety of fixed-ratio combination therapy (basal insulin + GLP-1 receptor agonist) compared to standard insulin therapy in patients with SID. In a selected group of patients, a randomised clinical trial would be conducted to assess the potential benefits of GLP-1 receptor agonists in the management of SID.
开始日期2025-07-10 |
CTRI/2024/10/075222
A Multicentre Phase IV single arm clinical trial to evaluate the safety and efficacy of a fixed ratio combination of Insulin Glargine and Lixisenatide in adult patients with Type 2 diabetes who are sub optimally controlled on oral anti-hyperglycemic drugs and/or basal Insulin/GLP-1 RA - iGlarLixi Phase 4 study in India
开始日期2024-10-28 |
100 项与 利司那肽 相关的临床结果
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100 项与 利司那肽 相关的转化医学
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100 项与 利司那肽 相关的专利（医药）
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528
项与 利司那肽 相关的文献（医药）2026-05-01·DIABETES-METABOLISM RESEARCH AND REVIEWS
Not All GLP‐1 Receptor Agonists Are Alike: Real‐World Evidence of Differential Endocrine and Dermatologic Safety
Article
作者: Nai Lee ; Yun Kim
ABSTRACT:
Aims:
Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) are widely used for metabolic disorders, but emerging safety concerns include alopecia and reproductive or endocrine‐related adverse events (AEs). This study investigated the association between specific GLP‐1 RAs and these endocrine‐related AEs using a large‐scale pharmacovigilance database.
Materials and Methods:
This study analysed the U.S. FDA Adverse Event Reporting System (FAERS) data (Q2 2022–Q2 2025) for six GLP‐1 Ras (exenatide, lixisenatide, liraglutide, dulaglutide, semaglutide, and tirzepatide) to identify alopecia‐ and reproductive or endocrine–related a AEs. Disproportionality analyses were conducted using crude and adjusted reporting odds ratios (cROR and aROR) from logistic regression controlling for potential confounding factors. Sensitivity analyses with positive and negative controls were used to validate the signal robustness.
Results:
A total of 1276 alopecia‐related and 759 reproductive or endocrine–related cases were identified. Semaglutide showed significant positive associations with alopecia (aROR 1.23 [1.11–1.35]) and reproductive/hormonal disorders, including polycystic ovary syndrome (aROR 6.59 [3.73–11.64]) and menstrual abnormalities. In contrast, dulaglutide and tirzepatide demonstrated negative associations for several reproductive outcomes (e.g., dysmenorrhoea, amenorrhoea, heavy menstrual bleeding), indicating lower reporting odds in this dataset. Sensitivity analyses using control drugs confirmed the consistency and specificity of these findings.
Conclusion:
This real‐world pharmacovigilance study identified agent‐specific differences in the endocrine and dermatologic safety profiles of GLP‐1 RAs. While semaglutide exhibited disproportionate reporting for alopecia and hormonal imbalance, dulaglutide and tirzepatide showed lower or non‐significant disproportionality signals for these events. These results highlight the need for personalised agent selection and continued pharmacovigilance to optimise long‐term patient safety.
2026-04-01·CURRENT OPINION IN NEUROBIOLOGY
The challenges of experimental pharmacology in identifying novel treatments for Parkinson's disease
Review
作者: Huot, Philippe ; Teil, Margaux
An important part of the field of experimental pharmacology encompasses the study of the effects of molecules in animals. In the case of Parkinson's disease (PD), animal models have played an invaluable role in refining our understanding of the disease, in characterizing the effect of new compounds on the illness, and in bringing new treatments to the clinic. Indeed, it is now hardly conceivable that a drug would be tested in humans if several parameters pertaining to safety, toxicology, efficacy, etc. had not previously been evaluated in animal models. Quite unfortunately, efficacy in experimental models of PD does not necessarily guarantee positive clinical outcomes. In this article, which primarily focusses on the past five years, we review drugs that entered clinical trials for the treatment of levodopa-induced dyskinesia, parkinsonism, disease modification, and had previously been assessed in animal models of PD. The drugs discussed are buspirone, JM-010, befiradol, mesdopetam, foliglurax, dipraglurant, tavapadon, prasinezumab, cinpanemab, nilotinib, minzasolmin, exenatide, NLY01, liraglutide, lixisenatide, and semaglutide. For each molecule, we examine how previous preclinical studies succeeded or failed in predicting efficacy in clinical trials and discuss possible ways to optimize animal-model design and selection to maximize the probability of translational success.
2026-04-01·DIABETES OBESITY & METABOLISM
Effect of lixisenatide on arterial stiffness in people with type 2 diabetes and kidney disease: Results of a randomised controlled trial
Article
作者: Corcillo, Antonella ; Goubar, Aicha ; Flaquer, Maria ; Pavlou, Panagiotis ; Fountoulakis, Nikolaos ; Stathi, Dimitra ; Ayis, Salma ; Karalliedde, Janaka ; Gnudi, Luigi
Abstract:
Objective:
People with chronic kidney disease (CKD) and diabetes are at high risk of cardiovascular disease (CVD). Aortic pulse wave velocity (Ao‐PWV) is an independent predictor of CVD. Cardiovascular outcome trials (CVOTs) with glucagon like peptide‐1 receptor agonist (GLP‐1 RA) class demonstrate notable differences, with lixisenatide having neutral effects as compared to longer acting GLP‐1 RA. It is unknown if shorter acting GLP‐1 RA have an impact on Ao‐PWV and if this may explain the discordance observed in GLP‐1RA CVOTs.
Materials and Methods:
We studied people with type 2 diabetes and CKD in a proof‐of‐concept single centre, randomised, double‐blind parallel‐group placebo‐controlled study that evaluated 24 weeks' treatment with lixisenatide as compared to placebo on the primary endpoint of Ao‐PWV.
Results:
In total, 101 participants (male 66%) were randomised of whom 90 were eligible for analyses (lixisenatide [
n
= 47] and placebo [
n
= 43]). Ao‐PWV did not change significantly from baseline after 24 weeks of treatment with final mean (95% confidence intervals) of 9.65 (9.17, 10.13) m/s with lixisenatide and 9.96 (9.45, 10.46) m/s with placebo,
p
= 0.38. Similarly, no significant changes were observed in cardio‐renal risk biomarkers including albuminuria and Klotho levels. HbA1c decreased with lixisenatide as compared to placebo.
Conclusions:
In people with CKD and type 2 diabetes the use of short‐acting GLP‐1 RA lixisenatide did not significantly influence Ao‐PWV. Further studies are needed to understand mechanisms that may explain discordance in CVOTs results observed with GLP‐1 RA.
Clinical Trial Registration:
ISRCTN: ISRCTN97699312; EudraCT/CTIS number: 2016‐001758‐17.
228
项与 利司那肽 相关的新闻（医药）2026-04-29
·博兮乐斯
这几年，“减肥针”几乎成了一个现象级词汇。
有人把它说成“减肥神药”，有人担心它会“把胃打坏”，也有人把它和明星瘦身、医美、身材焦虑绑在一起。
但如果把这些声音都先放一边，GLP-1 真正值得讨论的地方，其实不是“它能不能让人瘦”，而是它让我们重新看见了一个常被忽略的事实：
体重从来不只是意志力问题。
一个人为什么总是饿？为什么吃饱了还想吃？为什么减肥后很容易反弹？为什么肥胖常常和血糖、血脂、脂肪肝、高血压一起出现？
这些问题背后，不只是“管不住嘴”，而是一套由肠道、胃、胰腺、大脑和代谢系统共同参与的身体调控网络。
GLP-1 类药物的意义，也不只是“让人变瘦”。
它真正打开的是一扇窗口：我们开始更认真地理解食欲、饱腹、体重和代谢之间的关系。01 GLP-1 最早不是为了减肥而发现的
先说一个很多人不知道的事实：
GLP-1 的第一身份，并不是“减肥激素”。
GLP-1 的全称是 glucagon-like peptide-1，中文叫胰高糖素样肽-1。
名字听起来很硬核，但你可以把它理解成一种人体本来就会分泌的“饭后信号”。
当我们吃下食物后，肠道并不是安静地等待消化结束。它会感知营养物质进入身体，然后释放一些激素，把“食物来了”这个消息传递出去。
GLP-1 就是其中非常重要的一种。
它会告诉身体：
食物已经进入肠道了；血糖可能要升高了；胰腺可以准备工作了；胃可以慢一点排空了；大脑也该收到“已经吃了”的信号了。
换句话说，GLP-1 不是外来的神秘物质，而是我们身体里原本就存在的“代谢信使”。
科学家最早关注 GLP-1，源于一个很有意思的现象：
同样是葡萄糖，从嘴里吃进去，比直接打进静脉里，更能刺激胰岛素分泌。
这说明，肠道并不是一根被动的“食物管道”。
它会在食物进入身体后，主动向胰腺和大脑发信号，让身体提前进入“餐后代谢模式”。后来，这类由肠道释放、能够促进胰岛素分泌的激素，被称为肠促胰素。
GLP-1，就是肠促胰素家族里的重要成员。
所以，GLP-1 的故事一开始并不是关于“减肥”，而是关于一个更基础的问题：
身体是怎么知道我们吃了东西的？
02 从基础发现到药物：这条路走了几十年
既然人体本来就有 GLP-1，那是不是直接补充 GLP-1 就可以了？
问题在于：
天然 GLP-1 太短命了。
人体自己分泌出来的 GLP-1，很快就会被一种叫 DPP-4 的酶分解掉。在血液中，它通常只能存在几分钟。
作为身体里的即时信号，这已经够用了。但作为药物，这就太短了。
药物需要在体内停留足够久，才能产生稳定、可控的效果。于是，科学家开始想办法：
能不能保留 GLP-1 的作用，同时让它更稳定、更持久、更适合临床使用？
在这段发现史里，有一个很有记忆点的角色：美国毒蜥。
科学家在美国毒蜥的唾液中发现了一种叫 exendin-4 的肽。它和人类 GLP-1 有相似作用，也能激活 GLP-1 受体，但比天然 GLP-1 稳定得多。
后来，exendin-4 被开发成早期 GLP-1 类药物之一：艾塞那肽。
这件事很能说明现代药物研发的逻辑：
药物不是简单复制天然分子，而是在理解天然机制之后，对分子进行重新设计。
天然 GLP-1 告诉科学家：这个身体信号很重要。药物研发则继续回答：怎样让这个信号更稳定、更可控、更适合使用？
后来的利拉鲁肽、司美格鲁肽等药物，也都沿着这个方向发展：通过分子结构改造，让 GLP-1 类信号在体内停留更久，作用更稳定。
03所谓“减肥针”，其实不是一种药
很多人会把所有 GLP-1 相关药物都叫作“减肥针”。
但从科学上看，这个说法太笼统了。
它们不是一种药，而是一整个正在快速发展的代谢药物家族。
最经典的一类，叫 GLP-1 受体激动剂。
所谓“受体激动剂”，可以简单理解成：它像一把钥匙，能打开 GLP-1 受体这把锁，从而模拟人体自身 GLP-1 的信号。
代表药物包括：
艾塞那肽、利拉鲁肽、司美格鲁肽、度拉糖肽、利司那肽等。
它们的共同点是，都能通过 GLP-1 信号影响血糖、胃排空、食欲和体重管理。
但这一家族现在已经不只停留在单一 GLP-1 通路上。
第二类，是双靶点药物。
典型代表是替尔泊肽。它不仅作用于 GLP-1 受体，还作用于另一个肠促胰素受体：GIP 受体。
GIP 也是一种和进食、胰岛素分泌、能量代谢有关的激素。科学家希望通过同时调节两条通路，获得更强的代谢改善效果。
第三类，是正在发展的多靶点药物。
比如同时作用于 GLP-1、GIP 和胰高糖素受体的三靶点药物。它们试图同时影响食欲、血糖、脂肪代谢和能量消耗。
不过，靶点越多，并不等于一定越好。
靶点越多，机制越复杂，长期安全性、适用人群和风险边界也更需要研究。
所以，更准确地说：
“减肥针”不是一种药，而是一类围绕代谢信号设计出来的药物家族。
这也是为什么不同药物不能简单互相替代。它们的分子结构、作用时间、剂量递增方式、适应证和临床数据，都可能不同。
04GLP-1 为什么能让人变瘦？
这是大家最关心的问题。
很多人以为 GLP-1 是“燃脂针”，打进去之后脂肪就会被直接消耗掉。
这个理解并不准确。
GLP-1 不是直接把脂肪融掉，而是改变身体对进食和能量的调控方式。
它更像是在身体里按下了几个“代谢按钮”。
第一个按钮，是让胰岛素分泌更“看情况”。
GLP-1 可以增强胰岛素分泌，但它有一个重要特点：葡萄糖依赖性。
也就是说，当血糖升高时，它帮助胰腺释放更多胰岛素；当血糖不高时，它不会粗暴地让胰岛素大量释放。
这和很多人想象中的“强行降糖”不一样。
GLP-1 更像是一个餐后调度信号：它告诉胰腺，食物来了，血糖可能要上升，需要更有效地处理葡萄糖。
第二个按钮，是减少不必要的升糖信号。
人体里有一种激素叫胰高糖素。它的作用之一，是促进肝脏释放葡萄糖，让血糖升高。
GLP-1 能在一定程度上抑制胰高糖素，减少身体内部不必要的血糖输出。
第三个按钮，是让胃“慢一点”。
GLP-1 会延缓胃排空。简单说，就是食物从胃进入小肠的速度会变慢。
这会带来两个结果：
人更容易产生饱腹感；饱的时间也会更久。
这也是为什么一些人使用 GLP-1 类药物后，会明显觉得“吃一点就饱了”“不太想吃了”。
当然，这也解释了为什么一些人会出现恶心、腹胀、反酸、便秘或腹泻等胃肠道反应。
这些反应并不是完全偶然，而是和它影响胃肠功能的机制有关。
第四个按钮，也是最容易被忽略的一个：大脑。
我们常常以为，吃不吃、吃多少，完全取决于自控力。
但从生物学看，食欲不是一个简单的心理问题。它受到大脑、胃肠道、激素信号、营养状态和食物奖赏系统共同调控。
GLP-1 可以影响大脑中与饥饿、饱腹和食物奖赏相关的通路。
这就是为什么有些人使用后，不只是“胃口小了”，而是会描述一种更微妙的变化：
“没有那么总想着吃东西了。”“看到高热量食物也没那么上头了。”“吃饭这件事不再占据那么多注意力了。”
这背后不是玄学，而是食欲调控系统发生了变化。
所以，GLP-1 真正厉害的地方，不在于“让你硬忍着不吃”，而在于：
它改变了身体对饥饿、饱腹和食物奖赏的计算方式。
05减肥，真的不只是“靠忍”
说到减肥，很多人第一反应还是：
少吃一点。忍一忍。管住嘴。自律点。
这些话听起来简单，但对很多真正经历过长期体重管理的人来说，并不公平。
因为食欲不是一个开关，不是你想关就能关。
一个人为什么特别想吃甜食？为什么压力大时更容易吃高热量食物？为什么明明吃过饭，还是觉得“嘴巴很空”？为什么减肥一段时间后，身体像在拼命把体重拉回去？
这些都和身体的信号系统有关。
我们的大脑会接收来自胃肠道、脂肪组织、血糖水平和激素变化的信息，然后综合判断：
现在饿不饿？需不需要继续吃？吃什么会更有奖励感？身体能量够不够？体重下降是不是太快了？
所以，食欲并不只是“我想不想吃”。
它更像一场身体内部的协商：饥饿信号、饱腹信号、奖赏系统、压力状态和环境诱惑，都在参与投票。
GLP-1 类药物之所以能帮助一部分人控制体重，是因为它影响了这场“内部投票”的结果。
它让饱腹信号更容易被听见，让过强的进食驱动力下降，让高热量食物的诱惑变得没那么强。
这也是为什么说，GLP-1 的出现改变了我们理解肥胖的方式。
肥胖不应该被简单看成“懒”或“馋”。
它更应该被看成一个复杂的生物学、环境和行为共同作用的结果。
06为什么有人瘦得明显，有人效果一般？
GLP-1 类药物的效果，并不是人人一样。
这很正常。
因为肥胖本身就不是一种单一状态。
有些人的体重增加，主要和长期能量摄入过多有关；有些人伴随明显的胰岛素抵抗；有些人有脂肪肝、睡眠呼吸暂停、高血压或血脂异常；有些人受到压力、睡眠不足、药物、内分泌状态和遗传因素影响。
同样是“体重超标”，背后的生物学原因可能并不一样。
这就决定了，不同人对 GLP-1 的反应也不会完全一致。
另外，GLP-1 可以帮助降低食欲和改善部分代谢指标，但它不能自动替代所有健康行为。
它可以让一个人没那么想吃，但不能自动帮你保住肌肉量。
它可以减少能量摄入，但不能替你建立长期饮食结构。
它可以帮助体重下降，但不能保证停药后永远不反弹。
所以，判断 GLP-1 是否有效，不应该只看“一个月瘦了多少斤”。
更科学的观察指标包括：
体重有没有下降；腰围有没有减少；血糖有没有改善；血脂有没有改善；血压有没有改善；脂肪肝有没有改善；肌肉量有没有维持；生活质量有没有提升。
真正重要的不是体重秤上的一个数字，而是整个代谢状态有没有变好。07哪些人更适合 GLP-1？
GLP-1 类药物不应该被理解成普通美容瘦身工具。
它更适合的人群，是那些已经存在肥胖或超重，并且伴随代谢风险的人。
通常包括：
BMI 达到肥胖标准的人群；超重并伴有高血压的人群；超重并伴有血脂异常的人群；超重并伴有糖代谢异常的人群；超重并伴有脂肪肝的人群；超重并伴有睡眠呼吸暂停的人群；已经存在体重相关健康风险的人群。
换句话说，GLP-1 的核心使用场景不是：
“我想再瘦一点。”
而是：
体重已经开始成为健康风险的一部分。
一个体重正常的人，只是为了追求更瘦、更上镜、更快变轻，就把 GLP-1 当成身材管理工具，这并不是科学使用方式。
GLP-1的价值，不是帮助所有人追求更低体重，而是帮助一部分有明确体重和代谢风险的人，重新管理身体的能量系统。
具体能不能用、适合哪一种、剂量如何调整、是否需要停用，都必须由专业医生根据病史、检查结果、用药情况和风险因素判断。
08为什么说它不是神药？
GLP-1 的确改变了肥胖和代谢疾病治疗的格局。
它让人们看到，体重管理不只是“少吃多动”四个字，也可以进入更精细的生物学干预时代。
但它仍然不是神药。
因为它至少有四个边界。
第一，它不能让人随便吃。
GLP-1可以降低食欲，增强饱腹感，但它不能让高糖、高脂、高度加工饮食变得无害。
如果把它理解成“打了针就可以随便吃”，那就完全误解了它。
它更像是帮助身体降低过度进食冲动，而不是取消健康生活方式。
第二，它不能保证停药后不反弹。
体重不是一个静态数字，而是身体长期调控的结果。
当体重下降后，身体可能通过增加饥饿感、降低能量消耗等方式，把体重往回拉。
这就是为什么很多人减肥后会反弹。
GLP-1可以在使用期间帮助调节食欲和体重，但一旦停止，身体原本的调控系统可能重新占上风。
所以，长期体重管理不是一次性任务。
第三，它有副作用和禁忌。
GLP-1类药物常见的不良反应，多和胃肠道有关，比如恶心、呕吐、腹胀、腹泻、便秘、腹痛、反酸等。
此外，不同药物还需要关注胆囊、胰腺、低血糖风险，以及个人既往病史。
这也是为什么它必须在医生指导下使用，而不是靠社交平台经验、代购推荐或朋友分享来决定。
第四，非正规渠道风险很高。
GLP-1火了之后，网络上出现了很多所谓“平替版”“研究用”“复配版”“海外版”“无处方版”。
这类产品最大的问题，不只是“有没有效果”，而是你很难确认：
成分是否真实；剂量是否准确；杂质是否可控；保存运输是否合规；是否存在假药或非法复配；出现不良反应后是否可追溯。
越是热门药物，越容易被灰色市场包装成捷径。
但药物不是护肤品，更不是普通消费品。
用错了，不是没效果那么简单。09结语
如果只把 GLP-1 看成“减肥针”，其实低估了它。
它真正改变的，是我们理解肥胖的方式。
过去，肥胖常常被简单归因于懒、馋、没有自制力。
但 GLP-1 的研究告诉我们：
一个人为什么容易饿；为什么更偏好高热量食物；为什么减重后容易反弹；为什么肥胖常常和糖尿病、脂肪肝、高血压、高血脂一起出现。
这些问题背后，都有明确的内分泌、神经和代谢机制。
它真正值得被理解的地方在于：
科学正在把肥胖从道德评价，重新带回生物学问题。
体重管理不是一句“管住嘴、迈开腿”就能解释全部。
人的身体不是热量计算器，而是一个会感知、反馈、适应、抵抗改变的复杂系统。
GLP-1 的出现，让我们更清楚地看见了这个系统。
参考文献
1. GLP-1 receptor agonists: mechanisms and clinical applications, Nature / Signal Transduction and Targeted Therapy
2. NIDDK: The story of discovery behind GLP-1 medicines
3. EMA: Wegovy public assessment information
4. FDA: Concerns about unapproved GLP-1 drugs used for weight loss
5. 国家药监局及公开报道：司美格鲁肽长期体重管理适应证获批信息
— END —
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临床研究临床结果
2026-04-24
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截至04月24日15点59分，近期共有 496 本期刊发布了 988 篇文章，其中糖尿病相关的文章共 308 篇，覆盖 32 个领域的内容。中国专家参与发表的文章有 74 篇。今日，影响因子最高的文章刊登在 The Lancet (IF: 88.500) 期刊上。
今日头条
Headlines
01 Lancet Diabetes Endocrinol IF: 41.800 持续葡萄糖监测对比自我血糖监测在2型糖尿病患者中的随机、多中心、开放标签、优效性试验
Emma G Wilmot, Patrick Moore, Thozhukat Sathyapalan, Pratik Choudhary, Jonathan Z M Lim, Sankalpa Neupane, etc.
FreeDM2研究是一项在英国24个中心进行的开放标签、随机对照试验，旨在评估实时持续葡萄糖监测（CGM）对比自我血糖监测（SMBG）在2型糖尿病成人患者中的有效性和安全性。研究纳入303例使用基础胰岛素联合SGLT2抑制剂或GLP-1受体激动剂或双重GIP/GLP-1受体激动剂治疗但血糖控制不佳（糖化血红蛋白[HbA1c] 7.5%-11.0%）的患者，按2:1随机分配至CGM组（198例）或SMBG组（105例）。
试验采用独特的两阶段设计：第1-16周为自我管理阶段，患者根据CGM或SMBG数据自行调整基础胰岛素；第17-32周为临床支持阶段，医生可根据血糖数据加用其他降糖药物。
结果显示，在16周时，CGM组HbA1c从基线8.8%降至8.0%，而SMBG组仍为8.7%，校正后组间差异为-0.6%（95% CI -0.8~-0.3，P<0.0001）。在32周时，CGM组HbA1c进一步降至7.8%，SMBG组为8.3%，差异为-0.5%（95% CI -0.7~-0.2，P<0.0001）。CGM组达到HbA1c≤7.0%的比例在16周时为15%，而SMBG组仅为2%。
CGM组的目标范围内（3.9-10.0 mmol/L）时间显著增加，高血糖时间显著减少。两组低血糖时间均很低且相似。在自我管理阶段，尽管胰岛素剂量无组间差异，CGM组血糖改善更显著，提示获益可能源于生活方式改变。加速度计数据显示，16周时CGM组总体力活动轻度增加，饮食质量评分改善。
患者报告结局方面，CGM组对血糖监测的满意度更高，低血糖信心量表评分改善。安全性方面，两组非器械相关不良事件发生率相似，对照组发生2例严重低血糖，CGM组无严重低血糖事件。
研究结论认为，在基础胰岛素联合新型药物治疗的2型糖尿病患者中，实时CGM相比SMBG可显著改善血糖控制，且不增加低血糖风险，支持其在临床实践中的广泛应用。
本文由 韩玉莲 编辑
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Lancet Diabetes Endocrinol | Ahead of Print.
10.1016/S2213-8587(26)00076-8
02 Frontiers in endocrinology IF: 04.600 长期控制良好的1型糖尿病患者中小而密低密度脂蛋白谱的改变
Sardà, Helena, Solé, Arnau, Colom, Cristina, Borràs, Carla, Carreras, Gemma, Benítez, Sonia, etc.
一项发表于《Frontiers in Endocrinology》的横断面观察研究显示，长期血糖控制良好的1型糖尿病患者仍存在致动脉粥样硬化的小而密低密度脂蛋白（LDL）谱改变。
研究纳入69例病程较长的1型糖尿病患者和24名健康对照，所有患者平均糖化血红蛋白（HbA1c）为7.6%，血脂水平接近正常。结果显示，与对照组相比，1型糖尿病患者的小而密低密度脂蛋白胆固醇（LDL-C）浓度显著升高（0.56 vs. 0.43 mmol/L），小而密LDL-C/LDL-C比值增加（0.20 vs. 0.12），LDL颗粒直径减小（26.32 vs. 26.81 nm）。
在脂蛋白代谢调节因子方面，1型糖尿病患者的载脂蛋白C3浓度（8.67 vs. 6.53 mg/dL）、肝脂肪酶质量（46.60 vs. 15.45 ng/mL）和活性（1.03 vs. 0.89 U/mL）均显著高于对照组，而胆固醇酯转移蛋白活性显著降低（808.8 vs. 929.7 pmol/mL/h），内皮脂肪酶水平无显著差异。
相关性分析显示，小而密LDL-C与载脂蛋白C3呈显著正相关（r=0.7517），与胆固醇酯转移蛋白活性呈负相关（r=-0.2682）。
研究提示，即使传统血脂指标正常，1型糖尿病患者仍存在小而密LDL富集，这可能与载脂蛋白C3升高、肝脂肪酶活性增加和胆固醇酯转移蛋白活性降低有关。直接检测小而密LDL可能有助于更准确地评估该人群的心血管风险。
本文由 韩玉莲 编辑
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Frontiers in endocrinology | Volume 17, Issue
10.3389/fendo.2026.1804987
03 Diabetes, obesity & metabolism IF: 05.700 每天一次口服司美格鲁肽25 mg vs. 皮下注射司美格鲁肽2.4 mg用于伴或不伴2型糖尿病的肥胖症的有效性、安全性和药代动力学：——模型指导的药物开发方法
Overgaard, Rune Viig, Birkhan, Oscar, Rathor, Naveen, Sparsø, Thomas, Strathe, Anders, Wharton, Sean, etc.
一项基于模型指导的药物开发研究评估了每天一次口服司美格鲁肽25 mg在肥胖症患者中的有效性、安全性和药代动力学，并与已获批的皮下注射司美格鲁肽2.4 mg进行比较。研究利用历史数据和OASIS项目数据，通过群体药代动力学和暴露-反应分析，模拟了虚拟的II期和III期临床试验。
结果显示，在OASIS 4试验中，82.2%接受口服司美格鲁肽25 mg治疗的患者达到了与STEP 1试验中每周一次皮下注射司美格鲁肽2.4 mg患者相似的暴露水平。在模拟的虚拟试验中，对于超重/肥胖伴2型糖尿病的患者，口服司美格鲁肽25 mg相比安慰剂实现了显著更大的体重降幅：试验产品估计为9.4%，治疗策略估计为7.8%。对于超重/肥胖不伴2型糖尿病的患者，体重降幅分别为16.3%和14.7%。
研究结论认为，口服司美格鲁肽25 mg的估计暴露水平和有效性观察结果与皮下注射司美格鲁肽2.4 mg相似，这支持了口服司美格鲁肽25 mg用于治疗伴或不伴2型糖尿病的肥胖症患者。该研究为口服司美格鲁肽25 mg的监管批准提供了药代动力学和有效性方面的证据支持。
本文由 天纳乾坤 编辑
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Diabetes, obesity & metabolism | Ahead of Print.
10.1111/dom.70769
中国发表（74）
China
Molecular medicine IF: 06.400Ahead of Print.No.01Fludarabine disrupts the STAT1/AhR interaction to attenuate type 1 diabetes by inducing tolerogenic dendritic cells along with targeting effector T cells氟达拉滨通过破坏STAT1/AhR相互作用，诱导耐受性树突状细胞并靶向效应T细胞，从而减轻1型糖尿病DOI: 10.1186/s10020-026-01483-8
Cellular signalling IF: 03.700Ahead of Print.No.02Reactivating mitochondrial quality control via the Nrf2 pathway to combat metabolic stress in diabetic osteoarthritis通过Nrf2通路重新激活线粒体质量控制以对抗糖尿病性骨关节炎中的代谢应激DOI: 10.1016/j.cellsig.2026.112545
Ecotoxicol Environ Saf IF: 06.100Ahead of Print.No.03Parabens exposure, depression, and cardiovascular metabolic health in the elderly: Findings from a cross-sectional study in China老年人对羟基苯甲酸酯暴露、抑郁与心血管代谢健康：一项中国横断面研究结果DOI: 10.1016/j.ecoenv.2026.120153
European journal of pharmacology IF: 04.700Ahead of Print.No.04Corrigendum to "Cinnamaldehyde ameliorates diabetic kidney disease via anti-inflammatory effects: Bridging traditional use and molecular mechanisms" [Eur. J. Pharmacol. (2026) doi: 10.1016/j.ejphar.2026.178783]对《肉桂醛通过抗炎作用改善糖尿病肾病：传统应用与分子机制的桥梁》[Eur. J. Pharmacol. (2026) doi: 10.1016/j.ejphar.2026.178783]的勘误DOI: 10.1016/j.ejphar.2026.178883
Primary care diabetes IF: 02.300Ahead of Print.No.05The impact of sarcopenia on clinical outcomes in patients with diabetes: A systematic review and meta-analysis of cohort studies肌少症对糖尿病患者临床结局影响的系统评价与Meta分析DOI: 10.1016/j.pcd.2026.04.008
Life sciences IF: 05.100Volume 395, Issue No.06Myocardin-related transcription factor A contributes to diabetic nephropathy by activating integrin β2 in macrophages心肌相关转录因子A通过激活巨噬细胞中的整合素β2促进糖尿病肾病DOI: 10.1016/j.lfs.2026.124394
Journal of chromatography IF: 04.000Volume 1777, Issue No.07Rapid separation and enrichment of emodin and rhein in Sanhuang Xiexin Decoction by molecularly imprinted nanoparticles and evaluation of DPP-4 inhibitory activity分子印迹纳米颗粒快速分离富集三黄泻心汤中大黄素和大黄酸及DPP-4抑制活性评价DOI: 10.1016/j.chroma.2026.466979
Acta biomaterialia IF: 09.600Ahead of Print.No.08Adhesive polyethylene glycol hydrogels with metformin enabling in-situ drug delivery reprogramming immuno-metabolism for tissue repair in diabetic foot ulcers含二甲双胍的粘附性聚乙二醇水凝胶通过原位药物递送重编程免疫代谢促进糖尿病足溃疡组织修复DOI: 10.1016/j.actbio.2026.04.033
Life sciences IF: 05.100Ahead of Print.No.09Toward metabolic precision medicine in heart failure: Timing, tissue specificity, and network reconstruction迈向心力衰竭的代谢精准医学：时机、组织特异性和网络重建DOI: 10.1016/j.lfs.2026.124413
Journal of affective disorders IF: 04.900Ahead of Print.No.10Peripheral inflammation mediates the association between triglyceride-glucose index and cognitive impairment in comorbid major depressive disorder and type 2 diabetes: Translational implications for Alzheimer's disease risk via neuroinflammatory pathways外周炎症介导甘油三酯-葡萄糖指数与共病重度抑郁障碍和2型糖尿病认知障碍的关联：通过神经炎症通路对阿尔茨海默病风险的转化意义DOI: 10.1016/j.jad.2026.121830
Ecotoxicol Environ Saf IF: 06.100Ahead of Print.No.11Tryptophan metabolism in neonicotinoids exposure-induced diabetes: Emerging insights and predictive implications新烟碱类杀虫剂暴露诱发糖尿病中的色氨酸代谢：新见解与预测意义DOI: 10.1016/j.ecoenv.2026.120168
Endocrinol Diabetes Nutr (Engl Ed) IF: 01.800Volume 73, Issue 4No.12Bioelectrical impedance analysis-derived phase angle predicts sarcopenia in older adults with type 2 diabetes mellitus生物电阻抗分析衍生的相位角预测老年2型糖尿病患者的肌少症DOI: 10.1016/j.endien.2026.501717
Journal of hazardous materials IF: 11.300Ahead of Print.No.13Metabolite profiling of organophosphate ester exposure and type 2 diabetes mellitus risk: A metabolomics study in an epidemiological setting有机磷酸酯暴露与2型糖尿病风险的代谢物谱分析：一项流行病学背景下的代谢组学研究DOI: 10.1016/j.jhazmat.2026.142142
BMC surgery IF: 01.800Ahead of Print.No.14Case report: morbid obesity and lithotomy positioning: a high-risk triad with GCS leading to severe rhabdomyolysis with impending acute compartment syndrome following ovarian cancer cytoreduction病例报告：病态肥胖与截石位——卵巢癌减灭术后GCS导致严重横纹肌溶解并濒临急性筋膜室综合征的高危三联征DOI: 10.1186/s12893-026-03765-8
Nature communications IF: 15.700Ahead of Print.No.15EBF2 condensates enable adipose thermogenesis through ZFP423 sequestration and epigenetic remodelingEBF2凝聚体通过ZFP423隔离和表观遗传重塑实现脂肪产热DOI: 10.1038/s41467-026-72233-x
Journal of Advanced Research IF: 13.000Ahead of Print.No.16SUMOylation-deficient TRPV1 in sensory neurons confers resistance to high-fat diet-induced obesity via enhanced sympathetic adipose innervation感觉神经元中SUMOylation缺陷的TRPV1通过增强交感神经脂肪支配抵抗高脂饮食诱导的肥胖DOI: 10.1016/j.jare.2026.04.053
Antioxidants & redox signaling IF: 06.100Ahead of Print.No.17Iron Metabolism and Adipose Tissue Homeostasis: Emerging Perspectives for Obesity Intervention铁代谢与脂肪组织稳态：肥胖干预的新视角DOI: 10.1177/15230864261443818
Phytomedicine IF: 08.300Ahead of Print.No.18Sesamin ameliorates high-fat diet-induced inflammation and metabolic dysfunction in pregnant uterine smooth muscle via cGAS-STING inhibition芝麻素通过抑制cGAS-STING通路改善高脂饮食诱导的妊娠子宫平滑肌炎症和代谢功能障碍DOI: 10.1016/j.phymed.2026.158182
International immunopharmacology IF: 04.700Ahead of Print.No.19Zinc deficiency exacerbates and supplementation attenuates early-stage obesity-related podocyte injury via Nrf2/HO-1-mediated pyroptosis锌缺乏加重而补充锌通过Nrf2/HO-1介导的细胞焦亡减轻早期肥胖相关足细胞损伤DOI: 10.1016/j.intimp.2026.116703
Cell Mol Life Sci IF: 06.200Ahead of Print.No.20N6-methyladenosine (m6A) methylation in adipose tissue: role, regulation, and therapeutic potential脂肪组织中N6-甲基腺苷（m6A）甲基化的作用、调控及治疗潜力DOI: 10.1007/s00018-026-06201-5
Experimental gerontology IF: 04.300Ahead of Print.No.21Exploring the regulatory mechanisms of antidiabetic drugs on osteoporosis and Bone mineral density抗糖尿病药物对骨质疏松及骨密度调节机制的研究DOI: 10.1016/j.exger.2026.113142
Biochemical pharmacology IF: 05.600Ahead of Print.No.22Convergence of ER stress and ferroptosis in diabetic vasculopathy: therapeutic protection by ferrostatin-1内质网应激与铁死亡在糖尿病血管病变中的交汇：ferrostatin-1的治疗保护作用DOI: 10.1016/j.bcp.2026.117998
Eur J Med Chem IF: 05.900Ahead of Print.No.23Benzothiophene-based, orally active PIK3CA H1047R mutant-selective inhibitors for the treatment of HR+/HER2- breast cancer基于苯并噻吩的口服活性PIK3CA H1047R突变选择性抑制剂用于治疗HR+/HER2-乳腺癌DOI: 10.1016/j.ejmech.2026.118879
Pharmacological research IF: 10.500Ahead of Print.No.24Dual modulation of lipophagy: From molecular mechanisms to therapeutic interventions in cardiovascular health and disease脂噬的双重调控：从分子机制到心血管健康与疾病的治疗干预DOI: 10.1016/j.phrs.2026.108204
Experimental Eye Research IF: 02.700Ahead of Print.No.25TARGETING DRP1 ATTENUATES FERROPTOSIS AND DELAYS THE PROGRESSION OF DIABETIC RETINOPATHY靶向DRP1减轻铁死亡并延缓糖尿病视网膜病变进展DOI: 10.1016/j.exer.2026.111035
Nano letters IF: 09.100Ahead of Print.No.26Hybrid MXene/Hydrogel Integration with Modulated Bioactivities for Synergistic Diabetic Wound Therapy混合MXene/水凝胶整合调控生物活性用于协同糖尿病伤口治疗DOI: 10.1021/acs.nanolett.6c00565
J Neuropathol Exp Neurol IF: 03.000Ahead of Print.No.27The N6-methyladenosine (m6A) reader YTHDF3 increases PINK1/Parkin-mediated mitophagy by facilitating prohibitin 2 (PHB2) translation to promote retinal ganglion cell damage in diabetic retinopathym6A阅读蛋白YTHDF3通过促进prohibitin 2翻译增强PINK1/Parkin介导的线粒体自噬，加剧糖尿病视网膜病变中视网膜神经节细胞损伤DOI: 10.1093/jnen/nlag027
Cell biology and toxicology IF: 05.900Volume 42, Issue 1No.28Correction to: BMSC‑derived extracellular vesicles affect gluconeogenesis and lipogenesis by releasing 5'‑tRF‑GlyCCC to improve MAFLD insulin sensitivity更正：BMSC来源的细胞外囊泡通过释放5'-tRF-GlyCCC影响糖异生和脂肪生成以改善MAFLD胰岛素敏感性DOI: 10.1007/s10565-026-10187-y
Endocrine connections IF: 02.800Ahead of Print.No.29The IGF Signaling Axis in Thyroid Cancer: Biological Complexity and Therapeutic Challenges甲状腺癌中IGF信号轴：生物学复杂性与治疗挑战DOI: 10.1530/EC-26-0144
Hormones IF: 02.500Ahead of Print.No.30The association between the weight-adjusted waist circumference index (WWI) and thyroid function: an NHANES study体重调整腰围指数与甲状腺功能的关系：一项NHANES研究DOI: 10.1007/s42000-026-00781-4
The aging male IF: 02.600Volume 29, Issue 1No.31Relationship between Chinese visceral adiposity index and bone mineral density in patients with type 2 diabetes mellitus中国内脏脂肪指数与2型糖尿病患者骨密度的关系DOI: 10.1080/13685538.2026.2662050
Journal of diabetes IF: 03.700Volume 18, Issue 4No.32Atherogenic Index of Plasma Predicts the Onset and Progression of Cardio-Renal-Metabolic Multimorbidity: Evidence From a Nationwide Prospective Cohort Study血浆致动脉粥样硬化指数预测心肾代谢共病的发生和进展：来自全国前瞻性队列研究的证据DOI: 10.1111/1753-0407.70227
CNS neuroscience & therapeutics IF: 05.000Volume 32, Issue 4No.33Association of the Triglyceride-Glucose (TyG) Index and TyG-BMI With 1-Year Outcomes Following Endovascular Treatment in Acute Basilar Artery Occlusion甘油三酯-葡萄糖指数和甘油三酯-葡萄糖-体重指数与急性基底动脉闭塞血管内治疗后1年结局的关联DOI: 10.1002/cns.70898
iScience IF: 04.100Volume 29, Issue 5No.34Neutrophils and neutrophil extracellular traps in diabetes mellitus and its complications: Mechanisms and therapeutic implications中性粒细胞和中性粒细胞胞外陷阱在糖尿病及其并发症中的作用：机制与治疗意义DOI: 10.1016/j.isci.2026.115585
Exp Ther Med IF: 02.300Volume 31, Issue 6No.35Interacting proteins of AMPK studied using TurboID proximity labeling technology使用TurboID邻近标记技术研究AMPK的相互作用蛋白DOI: 10.3892/etm.2026.13144
Clin Exp Hepatol IF: 01.700Volume 11, Issue 4No.36Association of thyroid function and thyroid hormone sensitivity with all-cause and cardiovascular mortality in euthyroid patients with MASLD甲状腺功能及甲状腺激素敏感性与甲状腺功能正常的脂肪性肝病患者全因及心血管死亡率的关系DOI: 10.5114/ceh.2025.155479
Front Cell Dev Biol IF: 04.300Volume 14, Issue No.37pH/ROS-responsive smart hydrogels for infection control and immune microenvironment modulation in chronic wound healingpH/ROS响应性智能水凝胶在慢性伤口愈合中的感染控制与免疫微环境调节DOI: 10.3389/fcell.2026.1826583
Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.38Skin Organoids in Diabetic Chronic Wounds: Current Status and Future Perspectives皮肤类器官在糖尿病慢性创面中的应用：现状与未来展望DOI: 10.2147/DMSO.S598026
Frontiers in pharmacology IF: 04.800Volume 17, Issue No.39Ferroptosis regulation by SGLT2 inhibitors: mechanisms and clinical benefits in diabetic kidney diseaseSGLT2抑制剂调控铁死亡：糖尿病肾脏病中的机制与临床获益DOI: 10.3389/fphar.2026.1808167
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.40Lysosomal dysfunction in diabetes and diabetic complications糖尿病及其并发症中的溶酶体功能障碍DOI: 10.3389/fendo.2026.1794600
Cardiology in the Young IF: 00.900Ahead of Print.No.41The impact of gestational diabetes mellitus on neonatal cardiac development妊娠期糖尿病对新生儿心脏发育的影响DOI: 10.1017/S1047951126112268
BMC pregnancy and childbirth IF: 02.700Ahead of Print.No.42Longitudinal metabolomics reveals dynamic associations of trimethylamine N-oxide and precursors with the progression of gestational diabetes纵向代谢组学揭示氧化三甲胺及其前体与妊娠期糖尿病进展的动态关联DOI: 10.1186/s12884-026-09088-z
Sichuan Daxue xuebao. Yixue banVolume 57, Issue 2No.43[Association Between Blood Routine Index and Metabolic Syndrome in High-altitude Tibetan Population]高原藏族人群血常规指标与代谢综合征的关联研究DOI: 10.12182/20260360506
Sichuan Daxue xuebao. Yixue banVolume 57, Issue 2No.44[Apply the Miettinen Formula to Assess the Health Benefits of the PM(2.5) Simulation Intervention on Metabolic Syndrome]应用Miettinen公式评估PM2.5模拟干预对代谢综合征的健康收益DOI: 10.12182/20260360102
Actas espa?olas de psiquiatría IF: 01.600Volume 54, Issue 2No.45Severity of Cognitive Impairment and Its Correlation With Depressive Symptoms and Influencing Factors in Elderly Patients With Chronic Diseases老年慢性病患者认知障碍严重程度及其与抑郁症状和相关因素的相关性DOI: 10.62641/aep.v54i2.2166
Frontiers in pediatrics IF: 02.000Volume 14, Issue No.46Maternal risk factors for biliary atresia in neonates: a systematic review and meta-analysis新生儿胆道闭锁的母体危险因素：系统评价与荟萃分析DOI: 10.3389/fped.2026.1817265
Sexual medicine IF: 02.000Volume 14, Issue 3No.47PPP1R14A in male erectile dysfunction: key role in smooth muscle cellsPPP1R14A在男性勃起功能障碍中的作用：平滑肌细胞的关键角色DOI: 10.1093/sexmed/qfag021
IbrainVolume 12, Issue 1No.48Development of a predictive model for depressive symptoms in type 2 diabetes mellitus patients under community management: Based on visual function index基于视觉功能指数的社区管理2型糖尿病患者抑郁症状预测模型开发DOI: 10.1002/ibra.70014
Frontiers in nutrition IF: 05.100Volume 13, Issue No.49Association of dietary phytochemical index with sleep quality, and inflammatory markers in adults with type 2 diabetes: a cross-sectional study膳食植物化学指数与2型糖尿病成人睡眠质量和炎症标志物的关联：一项横断面研究DOI: 10.3389/fnut.2026.1766495
Postgraduate medicine IF: 02.800Ahead of Print.No.50Nonlinear relationship between the CHG index and MASLD in type 2 diabetes mellitus: mediating role of immunoinflammatory markers2型糖尿病患者CHG指数与代谢功能障碍相关脂肪性肝病的非线性关系：免疫炎症标志物的中介作用DOI: 10.1080/00325481.2026.2661571
Kaohsiung J Med Sci IF: 03.100Ahead of Print.No.51Correlations Among Glycemia and Glucose Variability, Thyroid Hormones, and Albuminuria in Patients With Type 2 Diabetes Mellitus2型糖尿病患者血糖及血糖变异性、甲状腺激素与白蛋白尿的相关性DOI: 10.1002/kjm2.70221
Curēus IF: 01.300Volume 18, Issue 3No.52Capivasertib-Induced Diabetes Successfully Managed With Insulin-Independent Glucose-Lowering Agents: A Case Report卡匹色替诱导的糖尿病成功使用非胰岛素依赖的降糖药物管理：一例病例报告DOI: 10.7759/cureus.105623
Frontiers in psychiatry IF: 03.200Volume 17, Issue No.53Analysis of the prevalence of dyslipidemia in early-onset schizophrenia patients and its correlation with clinical characteristics早发性精神分裂症患者血脂异常患病率及其与临床特征的相关性分析DOI: 10.3389/fpsyt.2026.1794475
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.54Systematic review of the efficacy and safety of biologically and tissue-derived therapies for the treatment of diabetic foot生物及组织来源疗法治疗糖尿病足的有效性和安全性的系统评价DOI: 10.3389/fendo.2026.1800592
Actas espa?olas de psiquiatría IF: 01.600Volume 54, Issue 2No.55Association Between Relative Fat Mass and Risk of Cognitive Impairment: The Role of Social Determinants of Health相对脂肪质量与认知障碍风险的关系：健康社会决定因素的作用DOI: 10.62641/aep.v54i2.2121
Food science & nutrition IF: 03.800Volume 14, Issue 4No.56Candidate Obesity Biomarkers Identified Through Multi-Omics Analysis, Mendelian Randomization, and Mediation Analysis通过多组学分析、孟德尔随机化和中介分析鉴定肥胖候选生物标志物DOI: 10.1002/fsn3.71803
Frontiers in nutrition IF: 05.100Volume 13, Issue No.57Correction: Comparative analysis of three BMI cutoffs for five metabolic abnormalities in the population of Western Guangdong, China更正：中国粤西地区人群中三种体重指数切点对五种代谢异常的比较分析DOI: 10.3389/fnut.2026.1835814
Brain and behavior IF: 02.700Volume 16, Issue 4No.58Association Between Visceral Adipose Tissue and Depression Risk With Both Observational and Genetic Evidence内脏脂肪组织与抑郁风险的关联：观察性和遗传学证据DOI: 10.1002/brb3.71392
Frontiers in veterinary science IF: 02.900Volume 13, Issue No.59From pathogenesis to prevention: an update on the management of obesity and its associated comorbidities in cats从发病机制到预防：猫肥胖及其相关合并症管理的最新进展DOI: 10.3389/fvets.2026.1797197
Biomedical chromatography IF: 01.700Volume 40, Issue 6No.60Study on Quality Markers for Hypoglycemic Effects of Moringa oleifera Leaves by the Integration of Network Pharmacology, Fingerprint, and Multi-Index Quantitative Analysis整合网络药理学、指纹图谱和多指标定量分析的辣木叶降糖有效性质量标志物研究DOI: 10.1002/bmc.70460
Actas espa?olas de psiquiatría IF: 01.600Volume 54, Issue 2No.61Association Between C-Reactive Protein-Triglyceride Glucose Index and Depressive Symptoms Among US Adults: A Nationally Representative Cross-Sectional Study From 2005 to 2023美国成年人C反应蛋白-甘油三酯葡萄糖指数与抑郁症状的关联：一项2005至2023年全国代表性横断面研究DOI: 10.62641/aep.v54i2.2163
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.62Sexually Dimorphic Impacts of Early Life BCAAs Supplementation on Metabolic Dysfunctions in Adult Mice早期支链氨基酸补充对成年小鼠代谢功能障碍的性别二态性影响DOI: 10.1111/dom.70809
Ecology and evolution IF: 02.300Volume 16, Issue 4No.63Comparative Genomics Reveals Genetic Adaptations to Diving-Associated Foraging in Anseriformes比较基因组学揭示雁形目潜水觅食相关遗传适应DOI: 10.1002/ece3.73551
Frontiers in immunology IF: 05.900Volume 17, Issue No.64Extracellular vesicles from Akkermansia muciniphila protect streptozotocin-induced diabetic mice by regulating glucose homeostasis, oxidative stress, and immune tolerance阿克曼菌来源的细胞外囊泡通过调节葡萄糖稳态、氧化应激和免疫耐受保护链脲佐菌素诱导的糖尿病小鼠DOI: 10.3389/fimmu.2026.1739048
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.65The triglyceride-to-HDL cholesterol ratio is associated with lower BMD in older adults at high altitudes: a retrospective retrospective cross sectional study甘油三酯与高密度脂蛋白胆固醇比值与高海拔地区老年人骨密度降低相关：一项回顾性横断面研究DOI: 10.3389/fendo.2026.1809643
Frontiers in nutrition IF: 05.100Volume 13, Issue No.66Food-derived dihydromyricetin and metabolic dysfunction-associated steatotic liver disease: a preclinical systematic review and meta-analysis食物来源的二氢杨梅素与代谢功能障碍相关脂肪性肝病：临床前系统评价和荟萃分析DOI: 10.3389/fnut.2026.1786758
Cancer communications IF: 24.900Volume 46, Issue No.67Camrelizumab Plus Nab-paclitaxel in Patients with Previously Treated Advanced Urothelial Carcinoma: A Multicenter Phase II Study卡瑞利珠单抗联合白蛋白紫杉醇治疗既往经治晚期尿路上皮癌患者：一项多中心II期研究DOI: 10.34133/cancomm.0025
Sichuan Daxue xuebao. Yixue banVolume 57, Issue 2No.68[A Study of the Association and Interaction Between Organophosphorus Pesticide Exposure and Insulin Resistance in Non-diabetic Adults]非糖尿病成人有机磷农药暴露与胰岛素抵抗的关联及交互作用研究DOI: 10.12182/20260360103
Sichuan Daxue xuebao. Yixue banVolume 57, Issue 2No.69[A Study on the Association Between Various Insulin Resistance Assessment Indices and IVF-ET Outcomes in Patients With Polycystic Ovary Syndrome]多种胰岛素抵抗评估指标与多囊卵巢综合征患者体外受精-胚胎移植结局的关联研究DOI: 10.12182/20260360208
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.70Association between goiter and type 2 diabetes in a Chinese population: a cross-sectional study using CHNS data中国人群中甲状腺肿与2型糖尿病的关联：基于CHNS数据的横断面研究DOI: 10.3389/fendo.2026.1763534
Frontiers in immunology IF: 05.900Volume 17, Issue No.71Integrative analysis of transcriptomics, single-cell RNA sequencing, and GraphBAN identifies de novo lipogenesis-associated genes and their potential roles in diabetic retinopathy转录组学、单细胞RNA测序和GraphBAN的整合分析鉴定糖尿病视网膜病变中与从头脂肪生成相关的基因及其潜在作用DOI: 10.3389/fimmu.2026.1803639
Int J Endocrinol IF: 02.300Volume 2026, Issue No.72Dynapenic Abdominal Obesity and Cognitive Impairment in Type 2 Diabetic Patients: A Single-Center Cross-Sectional Study2型糖尿病患者中腹型肥胖与认知障碍的关系：一项单中心横断面研究DOI: 10.1155/ije/6060666
BMC endocrine disorders IF: 03.300Ahead of Print.No.73The role of serum miR-28-5p in predicting diabetic retinopathy onset in type 2 diabetes血清miR-28-5p在预测2型糖尿病视网膜病变发病中的作用DOI: 10.1186/s12902-026-02272-4
Sichuan Daxue xuebao. Yixue banVolume 57, Issue 2No.74[A Study on the Relationship Between Cyclic Inflammatory Protein Fibroblast Growth Factor 21, Osteoporosis, and Fractures]循环炎症蛋白成纤维细胞生长因子21与骨质疏松症及骨折关系的研究DOI: 10.12182/20260360107
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The Journal of surgical research IF: 01.700Ahead of Print.No.23Extending the Observational Medical Outcomes Partnership Common Data Model to Support Observational Peripheral Vascular Disease Research扩展观察性医疗结果合作伙伴通用数据模型以支持观察性外周血管疾病研究DOI: 10.1016/j.jss.2026.03.089
The Journal of surgical research IF: 01.700Ahead of Print.No.24Identifying Factors Associated With Postdischarge Mortality After Readmission Following Pancreaticoduodenectomy胰十二指肠切除术后再入院患者出院后死亡相关因素分析DOI: 10.1016/j.jss.2026.03.109
Environment international IF: 09.700Ahead of Print.No.25Prenatal exposure to particulate matter impairs offspring behavior via hippocampal NMDA receptor reduction: an in vivo and ex vivo study产前颗粒物暴露通过海马NMDA受体减少损害子代行为：体内和体外研究DOI: 10.1016/j.envint.2026.110270
J Obstet Gynaecol Can IF: 02.200Ahead of Print.No.26Prevalence of Iron Deficiency and Anemia in Pregnancy in a Canadian Cohort and Definition of Normal Hemoglobin Ranges in Iron Replete Women加拿大妊娠期缺铁和贫血患病率及铁充足女性正常血红蛋白范围的定义DOI: 10.1016/j.jogc.2026.103370
Fundam Clin Pharmacol IF: 02.500Volume 40, Issue 3No.27Alogliptin Delays the Healing of Traumatic Oral Ulcers in the Buccal Mucosa of Wistar Rats阿格列汀延迟Wistar大鼠颊黏膜创伤性口腔溃疡愈合DOI: 10.1111/fcp.70090
Acta medica Okayama IF: 00.600Volume 80, Issue 2No.28Effects of Nonsurgical Periodontal Treatment on Bacterial and Clinical Parameters in Down Syndrome Patients Based on 16S rRNA Gene Amplicon Sequencing基于16S rRNA基因扩增子测序的非手术牙周治疗对唐氏综合征患者细菌和临床参数的影响DOI: 10.18926/AMO/70451
Nature communications IF: 15.700Ahead of Print.No.29MicroRNA-30c analog C2 decreases plasma cholesterol and atherosclerosis without causing liver injury in preclinical studiesMicroRNA-30c类似物C2在临床前研究中降低血浆胆固醇和动脉粥样硬化且不引起肝损伤DOI: 10.1038/s41467-026-72276-0
Endocrinol Diabetes Nutr (Engl Ed) IF: 01.800Volume 73, Issue 4No.30Assessment of arterial stiffness and plasma FGF23 levels in patients with hypoparathyroidism甲状旁腺功能减退症患者动脉僵硬度与血浆FGF23水平的评估DOI: 10.1016/j.endien.2026.501724
Am J Kidney Dis IF: 08.200Ahead of Print.No.31Association of Ertugliflozin on Kidney Outcomes in People After and Without an Interval Cardiovascular Event: Observations From the VERTIS CV Trial厄格列净对有无心血管事件间隔人群肾脏结局的影响：VERTIS CV试验观察DOI: 10.1053/j.ajkd.2026.01.017
Comput Biol Chem IF: 03.100Ahead of Print.No.32Structure-activity relationship-guided design of carbazole-thiazole hybrids as α-glucosidase inhibitors: DFT analysis, molecular modelling, ADMET prediction and in vivo validation基于构效关系指导的咔唑-噻唑杂合物作为α-葡萄糖苷酶抑制剂的设计：DFT分析、分子建模、ADMET预测及体内验证DOI: 10.1016/j.compbiolchem.2026.109077
J Am Pharm Assoc (2003)Ahead of Print.No.33Impact of a charitable medication program and social vulnerability index on clinical outcomes in uninsured adults with diabetes慈善药物项目和社会脆弱性指数对无保险成人糖尿病患者临床结局的影响DOI: 10.1016/j.japh.2026.103116
J Pharmacol Sci IF: 02.900Volume 161, Issue 2No.34Myricetin inhibits vascular calcification in an in vitro model by modulating ferroptosis-related SLC7A11/GPX4 signaling杨梅素通过调节铁死亡相关SLC7A11/GPX4信号通路抑制体外血管钙化DOI: 10.1016/j.jphs.2026.03.003
Endocrinol Diabetes Nutr (Engl Ed) IF: 01.800Volume 73, Issue 4No.35Vitamin D deficiency and depression in diabetes mellitus: A systematic review and meta-analysis糖尿病中维生素D缺乏与抑郁：系统综述和荟萃分析DOI: 10.1016/j.endien.2026.501743
Obesity IF: 04.700Ahead of Print.No.36Corrigendum to "Nutritional Priorities to Support GLP-1 Therapy for Obesity: A Joint Advisory From the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and The Obesity Society"《支持GLP-1治疗肥胖的营养优先事项：美国生活方式医学学会、美国营养学会、肥胖医学协会和肥胖学会的联合建议》勘误DOI: 10.1002/oby.70222
BMC surgery IF: 01.800Ahead of Print.No.37Impact of laparoscopic sleeve gastrectomy on obesity-related comorbidities in patients over 65 years: a prospective comparative study腹腔镜袖状胃切除术对65岁以上患者肥胖相关合并症的影响：一项前瞻性比较研究DOI: 10.1186/s12893-026-03707-4
Nutrition IF: 03.000Ahead of Print.No.38Investigating the relationship between nutrient intake patterns and obesity indices among Jordanians约旦人群营养素摄入模式与肥胖指标关系的研究DOI: 10.1016/j.nut.2026.113216
Obesity surgery IF: 03.100Ahead of Print.No.39Sequential Intragastric Balloon Followed By GLP-1 Receptor Agonist Therapy in Obesity: A Comparative Study of 12-Month Weight Loss Outcomes序贯胃内球囊联合GLP-1受体激动剂治疗肥胖症：12个月减重效果的比较研究DOI: 10.1007/s11695-026-08698-y
Indian J Gastroenterol IF: 02.100Ahead of Print.No.40The 'Obesity First' approach: Redefining the future of healthcare-An opinion“肥胖优先”策略：重新定义医疗保健的未来——一种观点DOI: 10.1007/s12664-026-02000-9
Neuropsychopharmacology IF: 07.100Ahead of Print.No.41Adolescent obesity induces sex-specific alterations of action control青少年肥胖导致行动控制的性别特异性改变DOI: 10.1038/s41386-026-02419-w
Nature medicine IF: 50.000Ahead of Print.No.42Genetics and GLP-1 drug responses遗传学与GLP-1药物反应DOI: 10.1038/d41591-026-00022-6
Nature genetics IF: 29.000Ahead of Print.No.43Genomic analyses implicate hormonal and metabolic dysregulation in polycystic ovary syndrome基因组分析揭示多囊卵巢综合征中的激素和代谢失调DOI: 10.1038/s41588-026-02543-9
Communications medicine IF: 06.300Ahead of Print.No.44Cross-organ MRI to assess the relationship between cardiac traits and cerebral white matter hyperintensity volumes跨器官磁共振成像评估心脏特征与脑白质高信号体积的关系DOI: 10.1038/s43856-026-01604-8
Am J Med Sci IF: 01.800Ahead of Print.No.45Comments on 'Effect of therapeutic lifestyle changes on patients with overweight/obesity and non-alcoholic fatty liver disease: A randomized controlled trial'对《治疗性生活方式改变对超重/肥胖合并非酒精性脂肪性肝病患者的影响：一项随机对照试验》的评论DOI: 10.1016/j.amjms.2026.04.007
Clinical nutrition ESPEN IF: 02.600Ahead of Print.No.46Online surveys, a breakthrough in research, especially in nutrition and food sciences在线调查：研究领域的突破，尤其在营养与食品科学中DOI: 10.1016/j.clnesp.2026.103299
Clinical nutrition ESPEN IF: 02.600Ahead of Print.No.47Nutritional surveillance and diet adherence in pediatric celiac disease: a multidisciplinary case-control study within a clinical nutrition model儿童乳糜泻的营养监测与饮食依从性：临床营养模型中的多学科病例对照研究DOI: 10.1016/j.clnesp.2026.103298
Journal of renal nutrition : IF: 03.200Ahead of Print.No.48Association between body mass index and survival in individuals on hemodialysis体重指数与血液透析患者生存率之间的关联DOI: 10.1053/j.jrn.2026.04.008
Molecular metabolism IF: 06.600Ahead of Print.No.49A distinct vagus-beta cell neural circuit senses glucose and modulates insulin secretion迷走神经-β细胞神经回路感知葡萄糖并调节胰岛素分泌DOI: 10.1016/j.molmet.2026.102371
Value in health IF: 06.000Ahead of Print.No.50Patient Preferences, Perceptions, and Influencing Factors in Weight Loss Pharmacotherapy and Bariatric Surgery: A Systematic Literature Review减重药物疗法与减重手术中的患者偏好、认知及影响因素：一项系统文献综述DOI: 10.1016/j.jval.2026.04.001
Medical care IF: 02.800Ahead of Print.No.51Diabetes Diagnosis Patterns in Medicaid: How State Policy, Managed Care, and Social Vulnerability Shape Detection in Medicaid医疗补助计划中的糖尿病诊断模式：州政策、管理式医疗和社会脆弱性如何影响检测DOI: 10.1097/MLR.0000000000002328
Infection, disease & health IF: 02.000Ahead of Print.No.52Surgical site infection following caesarean section: Incidence and healthcare resource utilisation in a tertiary mother and children hospital in Malaysia剖宫产术后手术部位感染：马来西亚一家三级妇幼医院的发病率和医疗资源利用情况DOI: 10.1016/j.idh.2026.100423
World J Surg Oncol IF: 02.500Ahead of Print.No.53Association of preoperative insulin resistance surrogate indices with the risk of anastomotic leakage after colorectal cancer resection: a multicenter retrospective cohort术前胰岛素抵抗替代指标与结直肠癌切除术后吻合口漏风险的相关性：一项多中心回顾性队列研究DOI: 10.1186/s12957-026-04367-7
J Mol Graph Model IF: 03.000Ahead of Print.No.54Unveiling the mechanism of action of Cymarin in combating breast cancer: An integrated computational analysis揭示西马林抗乳腺癌的作用机制：一项综合计算分析DOI: 10.1016/j.jmgm.2026.109416
Hormones IF: 02.500Ahead of Print.No.55Fasting safely during Ramadan with diabetes: clinical practice recommendations for Arab populations from the Arab Diabetes Forum (FSR-ADF)糖尿病患者斋月期间安全禁食：阿拉伯糖尿病论坛针对阿拉伯人群的临床实践建议（FSR-ADF）DOI: 10.1007/s42000-026-00783-2
The veterinary journal IF: 03.100Ahead of Print.No.56Effects of vatinoxan in horses sedated with detomidine and butorphanol for gastroscopy: a randomized clinical study瓦替诺生在右美托咪定和布托啡诺镇静马匹进行胃镜检查中的作用：一项随机临床研究DOI: 10.1016/j.tvjl.2026.106680
Molecular metabolism IF: 06.600Ahead of Print.No.57Systems Genetics Reveals ITIH5 as a Key Mediator of Adipocyte-Endothelial Crosstalk系统遗传学揭示ITIH5是脂肪细胞-内皮细胞串扰的关键介质DOI: 10.1016/j.molmet.2026.102373
Am J Prev Med IF: 04.500Ahead of Print.No.58Persistent sex differences in cardiovascular disease risk factors: a longitudinal cohort study in youth with type 1 diabetes心血管疾病危险因素的持续性性别差异：一项针对1型糖尿病青少年的纵向队列研究DOI: 10.1016/j.amepre.2026.108391
Endocrinol Diabetes Nutr (Engl Ed) IF: 01.800Volume 73, Issue 4No.59Psychopathological aspects of EDs in adolescents with type 1 diabetes: Findings from the DEPS-R and clinical outcomes1型糖尿病青少年进食障碍的精神病理学方面：来自DEPS-R和临床结局的发现DOI: 10.1016/j.endien.2026.501719
Endocrinol Diabetes Nutr (Engl Ed) IF: 01.800Volume 73, Issue 4No.60Myostatin in the pituitary-muscle axis: Roles in health and disease垂体-肌肉轴中的肌生成抑制素：在健康和疾病中的作用DOI: 10.1016/j.endien.2026.501757
Cardiovascular Research IF: 13.300Ahead of Print.No.61Integrated left ventricular multi-omics landscape of human cardiometabolic HFpEF人类心脏代谢性射血分数保留的心力衰竭的左心室多组学整合景观DOI: 10.1093/cvr/cvag084
Cell metabolism IF: 30.900Ahead of Print.No.62Cav3.1 is a neuronal leucine sensor that mediates satiety and weight loss in response to dietary proteinCav3.1是一种神经元亮氨酸传感器，介导膳食蛋白质引起的饱腹感和体重减轻DOI: 10.1016/j.cmet.2026.03.017
Cardiovasc Diabetol Endocrinol RepVolume 12, Issue 1No.63Efficacy and safety of semaglutide injection in Indian patients with type 2 diabetes mellitus inadequately controlled on metformin: a phase 3, randomized, active-controlled trial (SIZE-DM study)司美格鲁肽注射液在二甲双胍控制不佳的印度2型糖尿病患者中的有效性和安全性：一项3期、随机、活性对照试验（SIZE-DM研究）DOI: 10.1186/s40842-026-00290-8
J Am Pharm Assoc (2003)Ahead of Print.No.64Semaglutide for obesity management: A narrative review of efficacy, safety, and future directions司美格鲁肽用于肥胖管理：有效性、安全性和未来方向的叙述性综述DOI: 10.1016/j.japh.2026.103117
Am J Ophthalmol IF: 04.200Ahead of Print.No.65Glucagon-Like Peptide-1 Receptor Agonists and Risk of Systemic and Ocular Vascular Complications in Patients with Type 2 Diabetes and Diabetic Retinopathy胰高血糖素样肽-1受体激动剂与2型糖尿病合并糖尿病视网膜病变患者全身及眼部血管并发症风险DOI: 10.1016/j.ajo.2026.04.021
Acta Physiologica IF: 05.600Volume 242actaphysiologica, Issue 5, Page e70213-e70215No.66Adhesion GPCRs as Hot Targets for Obesity黏附G蛋白偶联受体成为肥胖治疗的热门靶点DOI: 10.1111/apha.70225
Am J Prev Cardiol IF: 05.900Ahead of Print.No.67Body Mass Index, Waist-to-Height Ratio, and the Risks of Premature Heart Failure in Adults Age Under 45体重指数、腰围身高比与45岁以下成年人早发性心力衰竭的风险DOI: 10.1016/j.ajpc.2026.101650
The Lancet IF: 88.500Volume 407, Issue 10539, Page 1573-1656No.68Semaglutide, weight loss, and cardiovascular outcomes in the SELECT trial – Authors' replySELECT试验中司美格鲁肽、减重与心血管结局——作者回复DOI: 10.1016/S0140-6736(26)00706-3
Indian J Med Res IF: 02.500Volume 163, Issue 3No.69Association of GCKR and GLIS3 gene polymorphisms with gestational diabetes mellitus: A case-control studyGCKR和GLIS3基因多态性与妊娠期糖尿病的关联：一项病例对照研究https://pubmed.ncbi.nlm.nih.gov/42024906
JMIR diabetes IF: 02.600Volume 11, Issue No.70The Process of Developing an Intervention to Increase Awareness of Cardiovascular Risk for Persons With Type 2 Diabetes: Co-Creation Study为2型糖尿病患者开发提高心血管风险意识干预措施的过程：共创研究DOI: 10.2196/85748
Physiother Res Int IF: 01.800Volume 31, Issue 2No.71Measurement Properties of the Modified Incremental Step Test for Assessing Exercise Capacity in Individuals With Type 2 Diabetes改良递增台阶试验评估2型糖尿病患者运动能力的测量特性DOI: 10.1002/pri.70224
ACS applied bio materials IF: 04.700Ahead of Print.No.72Engineering MoS(2)/CoSe(2) Hybrid Nanocomposites for Efficient Regeneration of Bacterially Infected Diabetic Wounds工程化MoS₂/CoSe₂杂化纳米复合材料用于细菌感染糖尿病伤口的高效再生DOI: 10.1021/acsabm.5c02244
Ophthalmic Plast Reconstr Surg IF: 01.300Ahead of Print.No.73Is Cataract Surgery a Risk Factor for New-Onset Thyroid Eye Disease?白内障手术是新发甲状腺眼病的危险因素吗？DOI: 10.1097/IOP.0000000000003218
JCI insight IF: 06.100Ahead of Print.No.74Preservation of pancreatic endocrine and peri-islet exocrine capillary networks in type 2 diabetes2型糖尿病中胰腺内分泌和胰岛周围外分泌毛细血管网络的保留DOI: 10.1172/jci.insight.202118
J Clin Invest IF: 13.600Ahead of Print.No.75The N-terminus of Apolipoprotein B mediates the interaction of atherogenic lipoproteins with endothelial cells载脂蛋白B的N端介导致动脉粥样硬化脂蛋白与内皮细胞的相互作用DOI: 10.1172/JCI190513
Obstetrics and Gynecology IF: 04.700Ahead of Print.No.76Screening for Cervical Cancer: A Recommendation From the Women's Preventive Services Initiative宫颈癌筛查：妇女预防服务倡议的建议DOI: 10.1097/AOG.0000000000006315
Can J Diet Pract Res IF: 00.700Ahead of Print.No.77School Nutrition Education in Canada: Call to Action for Dietitians to Advocate for Social Justice加拿大学校营养教育：呼吁营养师倡导社会正义DOI: 10.3148/cjdpr-2026-001
Science IF: 45.800Ahead of Print.No.78Severe obesity in human HFpEF alters contractile protein function and organization人类射血分数保留的心力衰竭中严重肥胖改变收缩蛋白功能和组织DOI: 10.1126/science.adz7118
Revista médica de Chile IF: 00.300Volume 154, Issue 2No.79[Obesity in Chile: A Worrying Future]智利肥胖问题：令人担忧的未来DOI: 10.4067/s0034-98872026000200288
Revista médica de Chile IF: 00.300Volume 154, Issue 2No.80[Pharmacological Activation of ERRα/β/γ as an Exercise Mimetic: Potential Therapeutic Applications]ERRα/β/γ的药理学激活作为运动模拟物：潜在的治疗应用DOI: 10.4067/s0034-98872026000200237
PLoS medicine IF: 09.900Volume 23, Issue 4No.81Identification of lipid quantitative trait loci linked with cardiometabolic disease in Asian Indians and Europeans: A genome-wide association study and mendelian randomization亚洲印度人与欧洲人中心血管代谢疾病相关脂质数量性状位点的鉴定：一项全基因组关联研究和孟德尔随机化分析DOI: 10.1371/journal.pmed.1005039
Rev Esp Cir Ortop TraumatolVolume 70, Issue 1No.82Prevalence of diabetic foot in patients with diabetes mellitus undergoing dialysis treatment in a tertiary-level hospital in Argentina阿根廷某三级医院接受透析治疗的糖尿病患者中糖尿病足的患病率DOI: 10.1016/j.recot.2025.11.012
Rev Esp Cir Ortop TraumatolVolume 70, Issue 1No.83Prevalence of diabetic foot in patients with diabetes mellitus undergoing dialysis treatment in a tertiary-level hospital in Argentina阿根廷某三级医院接受透析治疗的糖尿病患者中糖尿病足的患病率DOI: 10.1016/j.recot.2025.04.018
Heart Rhythm IF: 05.700Ahead of Print.No.84Glucagon-Like Peptide-1 and Atrial Fibrillation Incidence: Associations Independent of Weight Loss胰高血糖素样肽-1与心房颤动发生率：独立于体重减轻的关联DOI: 10.1016/j.hrthm.2026.03.1940
Journal of endocrinology IF: 03.900Ahead of Print.No.85Caloric restriction exerts site-, sex-, and duration-dependent effects on skeletal structure and bone marrow adiposity热量限制对骨骼结构和骨髓脂肪的影响具有部位、性别和持续时间依赖性DOI: 10.1530/JOE-25-0391
Pol Arch Intern Med IF: 04.700Ahead of Print.No.86Diagnostic utility of non-invasive tests for significant liver fibrosis in people with metabolic dysfunction-associated steatotic liver disease非侵入性检测在代谢功能障碍相关脂肪性肝病患者显著肝纤维化中的诊断效用DOI: 10.20452/pamw.17277
Naunyn Schmiedebergs Arch Pharmacol IF: 03.100Ahead of Print.No.87Investigating the therapeutic effects of caffeine-naringenin combination on the repair of intestinal permeability and composition of gut microbiota in obese rats under long-term high-fat diet咖啡因-柚皮素组合对长期高脂饮食肥胖大鼠肠道通透性修复及肠道菌群组成的治疗作用研究DOI: 10.1007/s00210-026-05136-9
Psychiatric quarterly IF: 02.900Ahead of Print.No.88History of Cannabis Use and Obesity Among U.S. Low-Income Veterans: Associations With Mental Health and Psychosocial Functioning美国低收入退伍军人大麻使用史与肥胖：与心理健康及社会心理功能的关联DOI: 10.1007/s11126-026-10284-5
Med Sci Sports Exerc IF: 03.900Ahead of Print.No.89Combination of Intermittent Hypoxic Exposure and Exercise Improves Body Composition and Glucose Tolerance in High-Fat Diet-Induced Obese Mice间歇性低氧暴露与运动联合改善高脂饮食诱导肥胖小鼠的身体成分和葡萄糖耐量DOI: 10.1249/MSS.0000000000004015
Kathmandu Univ Med J (KUMJ)Volume 23, Issue 90No.90Double Burden of Malnutrition among Mother-Child Dyads in a Rural Area of West Bengal, India: A Comprehensive Analysis of Contributing Factors印度西孟加拉邦农村地区母子二元营养双重负担的综合分析https://pubmed.ncbi.nlm.nih.gov/42023568
Kathmandu Univ Med J (KUMJ)Volume 23, Issue 90No.91Serum Uric Acid and its Correlation with Inflammation in Hypertension, a Hospital Based Case-control Study血清尿酸与高血压炎症的相关性：一项基于医院的病例对照研究https://pubmed.ncbi.nlm.nih.gov/42023562
JAMA Network Open IF: 09.700Volume 9, Issue 4No.92Vitamin D Receptor Polymorphism-A D-Terminant for Vitamin D's Association With Risk for Type 2 Diabetes维生素D受体多态性——维生素D与2型糖尿病风险关联的决定因素DOI: 10.1001/jamanetworkopen.2026.7315
JAMA Network Open IF: 09.700Volume 9, Issue 4No.93Vitamin D Receptor Polymorphisms and the Effect of Vitamin D Supplementation on Diabetes Risk Among Adults With Prediabetes维生素D受体多态性与维生素D补充对糖尿病前期成人糖尿病风险的影响DOI: 10.1001/jamanetworkopen.2026.7332
Wounds IF: 01.100Volume 38, Issue 1No.94Reporting of social demographics in diabetic foot ulcer randomized controlled trials: a scoping review糖尿病足溃疡随机对照试验中社会人口学报告的范围综述DOI: 10.25270/wnds/25020
Hormones IF: 02.500Ahead of Print.No.95Endocrine disruptors are contributing to type 2 diabetes mellitus内分泌干扰物促进2型糖尿病的发生DOI: 10.1007/s42000-026-00779-y
Journal of proteome research IF: 03.600Ahead of Print.No.96Machine Learning Analysis of Serum Metabolomics for Multi-Disease Classification and Proteome-Metabolome Pathway Insights in T2D, IBD, and CRC基于机器学习分析血清代谢组学用于T2D、IBD和CRC的多疾病分类及蛋白质组-代谢组通路洞察DOI: 10.1021/acs.jproteome.5c01212
Journal of Alzheimer's disease IF: 03.100Ahead of Print.No.97Larger baseline body stature predicts one-year amyloid change in cognitively normal older adults enriched with elevated amyloid status较大基线体型预测认知正常且淀粉样蛋白水平升高的老年人一年内淀粉样蛋白变化DOI: 10.1177/13872877261445598
Rev Esp Cir Ortop TraumatolVolume 69, Issue 6No.98[Translated article] Gender and diabetes mellitus do not influence the outcomes of patients with proximal humeral fractures treated with a reverse shoulder arthroplasty性别和糖尿病不影响接受反向肩关节置换术的肱骨近端骨折患者的预后DOI: 10.1016/j.recot.2025.07.012
Liver transplantation : IF: 03.900Ahead of Print.No.99Multi-modal machine learning highlights recipient genetic and clinical factors as primary drivers of post-transplant MASLD: A two-center study多模态机器学习揭示受者遗传和临床因素是移植后代谢相关脂肪性肝病的主要驱动因素：一项两中心研究DOI: 10.1097/LVT.0000000000000881
Nutrición hospitalaria IF: 01.100Ahead of Print.No.100Associations of C-reactive protein-triglyceride-glucose index cumulative burden with incident cardiovascular disease in middle-aged and older Chinese adults with abnormal glucose metabolismC反应蛋白-甘油三酯-葡萄糖指数累积负担与中老年糖代谢异常中国成人新发心血管疾病的关联DOI: 10.20960/nh.06533
J Diabetes Investig IF: 03.000Ahead of Print.No.101A review of capillary β-hydroxybutyrate cut-off levels for the exclusion and identification of diabetic ketoacidosis毛细血管β-羟基丁酸截断值用于排除和识别糖尿病酮症酸中毒的综述DOI: 10.1111/jdi.70317
Alzheimer's & dementia IF: 11.100Volume 22, Issue 4No.102Diabetes, hyperglycemia, and ATN blood biomarkers in Hispanic/Latino populations: SOL-INCA study糖尿病、高血糖与西班牙裔/拉丁裔人群ATN血液生物标志物的关联：SOL-INCA研究DOI: 10.1002/alz.71223
Pediatr Endocrinol Diabetes MetabVolume 32, Issue 1No.103Dysmorphic syndromes with overgrowth - systematic review, part 2: chromosomal and epigenetic disorders and disorders associated with dynamic mutations伴有过度生长的畸形综合征——系统综述第二部分：染色体和表观遗传疾病以及与动态突变相关的疾病DOI: 10.5114/pedm.2026.159968
Pediatr Endocrinol Diabetes MetabVolume 32, Issue 1No.104Determination of a higher hypoglycemic threshold in the insulin tolerance test for children with short stature矮身材儿童胰岛素耐量试验中更高低血糖阈值的确定DOI: 10.5114/pedm.2026.159674
BJOG IF: 04.700Ahead of Print.No.105Pre-Pregnancy Body Mass Index, Diabetes Status, and Gestational Age-Specific Stillbirth Risk: A Nationwide Retrospective Cohort Study孕前体重指数、糖尿病状态与孕周特异性死产风险：一项全国性回顾性队列研究DOI: 10.1111/1471-0528.70247
Endocrine connections IF: 02.800Ahead of Print.No.106Factors affecting the quality of life of adults living with Congenital Adrenal Hyperplasia: A qualitative study of lived experience影响先天性肾上腺皮质增生症成人患者生活质量的因素：一项关于生活体验的定性研究DOI: 10.1530/EC-26-0033
Rev Esp Cir Ortop TraumatolAhead of Print.No.107[Not Available]腰椎后路融合术后急性感染的危险因素分析DOI: 10.1016/j.recot.2026.03.008
JAMA ophthalmology IF: 09.200Ahead of Print.No.108Brolucizumab in the Treatment of Proliferative Diabetic Retinopathy: The CONDOR Randomized Clinical TrialBrolucizumab治疗增殖性糖尿病视网膜病变：CONDOR随机临床试验DOI: 10.1001/jamaophthalmol.2026.1008
Archives of osteoporosis IF: 02.800Volume 21, Issue 1No.109Association between bone health and cardiovascular events in a population-based cohort基于人群的队列研究中骨骼健康与心血管事件之间的关联DOI: 10.1007/s11657-026-01704-x
Rev Esp Cir Ortop TraumatolVolume 69, Issue 6No.110Clinical outcomes of closuring technique in total hip arthroplasty and total knee arthroplasty: A comparative study of staples technique vs triclosan-coated barbed sutures全髋关节置换术和全膝关节置换术中闭合技术的临床结果：钉合技术与三氯生涂层倒刺缝线的比较研究DOI: 10.1016/j.recot.2025.07.010
Pediatr Endocrinol Diabetes MetabVolume 32, Issue 1No.111Graves' disease and autoimmune hepatitis overlap syndrome with coincidental simultaneous presentation in a pediatric patient儿童患者格雷夫斯病与自身免疫性肝炎重叠综合征的偶然同时出现DOI: 10.5114/pedm.2026.160225
Otolaryngologia Polska IF: 00.600Volume 80, Issue 2No.112Management of COVID associated invasive fungal sinusitisCOVID相关侵袭性真菌性鼻窦炎的管理DOI: 10.5604/01.3001.0055.6613
Pediatr Endocrinol Diabetes MetabVolume 32, Issue 1No.113Ketoacidosis in new-onset type 1 diabetes: return to pre-COVID-19 pandemic reality?新发1型糖尿病酮症酸中毒：回归COVID-19大流行前现实？DOI: 10.5114/pedm.2026.159708
The Lancet Digital Health IF: 24.100Ahead of Print.No.114Detection of young-onset type 2 diabetes using deep learning across primary and secondary care: a nationwide, retrospective cohort study利用深度学习在初级和二级医疗中检测青少年起病的成人型糖尿病：一项全国性回顾性队列研究DOI: 10.1016/j.landig.2025.100968
JMCC IF: 04.700Ahead of Print.No.115Pathophysiology and pharmacotherapy of cardiovascular complications in metabolic syndrome代谢综合征心血管并发症的病理生理学与药物治疗DOI: 10.1016/j.yjmcc.2026.04.007
JGH open : IF: 01.500Volume 10, Issue 3No.116Loss of Response to Anti-Tumor Necrosis Factor Alpha Therapy in Patients With Inflammatory Bowel Disease: A Real-World Comparison of Combination Therapy Versus Monotherapy炎症性肠病患者抗肿瘤坏死因子α治疗有效性丧失：联合治疗与单药治疗的真实世界比较DOI: 10.1002/jgh3.70385
J Taibah Univ Med Sci IF: 01.900Volume 21, Issue 3No.117Frequency and comorbidities of age-related macular degeneration in KSA: A retrospective multiregional study沙特阿拉伯年龄相关性黄斑变性的频率与合并症：一项多区域回顾性研究DOI: 10.1016/j.jtumed.2026.03.009
Curēus IF: 01.300Volume 18, Issue 3No.118Assessment of Outcomes of Endonasal Dacryocystorhinostomy in a Tertiary Referral Center三级转诊中心鼻内镜下泪囊鼻腔吻合术的疗效评估DOI: 10.7759/cureus.105621
Health science reports IF: 02.100Volume 9, Issue 3No.119Optimal Wound pH and Related Factors in the Healing Process of Diabetes-Related Foot Ulcer: A Prospective Observational Study糖尿病相关足溃疡愈合过程中的最佳伤口pH值及相关因素：一项前瞻性观察性研究DOI: 10.1002/hsr2.72079
Health science reports IF: 02.100Volume 9, Issue 3No.120Associations Between the Severity of Obstructive Sleep Apnea and Arterial Stiffness Estimated by Pulse Wave Velocity Assessment: A Cross-Sectional Study阻塞性睡眠呼吸暂停严重程度与脉搏波速度评估的动脉僵硬度之间的关联：一项横断面研究DOI: 10.1002/hsr2.71861
Health science reports IF: 02.100Volume 9, Issue 3No.121Assessment of Quality of Care Provided for Patients Receiving Post-Myocardial Infarction Care at Selected Cardiac Clinics in Sulaymaniyah: Cross-Sectional Study苏莱曼尼亚选定心脏诊所心肌梗死后患者护理质量评估：横断面研究DOI: 10.1002/hsr2.72099
Chronic Dis Transl MedVolume 12, Issue 1No.122Self-Management Interventions in Young Adults (18-30 Years) With Type 1 Diabetes, Sickle Cell Disease, and Inflammatory Bowel Disease: A Scoping Review年轻成人（18-30岁）1型糖尿病、镰状细胞病和炎症性肠病自我管理干预的范围综述DOI: 10.1002/cdt3.70032
Frontiers in pharmacology IF: 04.800Volume 17, Issue No.123Barriers to prescribing and insurance approval of SGLT2 inhibitors for heart failure: a mixed-methods study in Jordan约旦心力衰竭患者处方和保险审批中使用钠-葡萄糖协同转运蛋白2抑制剂的障碍：一项混合方法研究DOI: 10.3389/fphar.2026.1803731
JCEM case reportsVolume 4, Issue 5No.124Ultra-rapid prolactin normalization with cabergoline in a premenopausal woman with epilepsy and giant prolactinoma卡麦角林在绝经前女性癫痫合并巨大泌乳素瘤患者中实现泌乳素超快速正常化DOI: 10.1210/jcemcr/luag105
Public health challengesVolume 5, Issue No.125Determinants of Health-Seeking Behavior and Quality of Life in Patients With Noncommunicable Diseases in Bangladesh孟加拉国非传染性疾病患者健康寻求行为与生活质量的决定因素DOI: 10.1002/puh2.70238
Clinical nephrology IF: 01.000Ahead of Print.No.126Impact of different A1c targets on cardiovascular outcomes in diabetic kidney transplant recipients: A global cohort analysis不同A1c目标对糖尿病肾移植受者心血管结局的影响：一项全球队列分析DOI: 10.5414/CN111994
Gut and liver IF: 03.200Ahead of Print.No.127The Chronic Hepatitis B and Metabolic Dysfunction-Associated Steatotic Liver Disease Paradox: Friend or Foe?慢性乙型肝炎与代谢功能障碍相关脂肪性肝病的悖论：朋友还是敌人？DOI: 10.5009/gnl250444
Epidemiologia e prevenzione IF: 01.500Volume 50, Issue 2No.128Diabetes, disease management, and risk of mortality by immigrant status: a population-based cohort study in Reggio Emilia Province (Northern Italy)糖尿病、疾病管理与移民状态下的死亡风险：意大利雷焦艾米利亚省一项基于人群的队列研究DOI: 10.19191/EP26.2.A1018.033
LUTS IF: 01.500Volume 18, Issue 3No.129Rates and Predictors of Persistent LUTS Medication Use After Laser Enucleation of the Prostate前列腺激光剜除术后持续使用下尿路症状药物的比率及预测因素DOI: 10.1111/luts.70062
Proc Inst Mech Eng H IF: 01.500Ahead of Print.No.130Finite element framework for investigating the mechanical response of podiatric insole: A pilot study足部矫形鞋垫力学响应研究的有限元框架：一项初步研究DOI: 10.1177/09544119261434625
Respirology case reports IF: 00.800Volume 14, Issue 3No.131IgG4-Related Lung Disease in a Former Smoker: A Challenging Diagnosis一例既往吸烟者中的IgG4相关性肺病：具有挑战性的诊断DOI: 10.1002/rcr2.70538
Frontiers in aging IF: 04.300Volume 7, Issue No.132Therapeutic peptides in gerontology: mechanisms and applications for healthy aging老年学中的治疗性肽：健康衰老的机制与应用DOI: 10.3389/fragi.2026.1790247
Health science reports IF: 02.100Volume 9, Issue 4No.133Different SARS-CoV-2 Subvariants and Coagulation Markers Trend: A Retrospective Multicentric Study From Iranian Network for Research in Viral Diseases (INRVD)不同SARS-CoV-2亚型与凝血标志物趋势：来自伊朗病毒性疾病研究网络的回顾性多中心研究DOI: 10.1002/hsr2.72390
J Family Med Prim Care IF: 01.000Volume 15, Issue 2No.134Bone mineral density in children and adolescents with type 1 diabetes: A case-control study from South India1型糖尿病儿童和青少年骨密度：来自南印度的病例对照研究DOI: 10.4103/jfmpc.jfmpc_1637_24
J Family Med Prim Care IF: 01.000Volume 15, Issue 2No.135Screening practices and risk factors for diabetic foot complications among patients with diabetes at a tertiary centre in Riyadh, Saudi Arabia沙特阿拉伯利雅得一家三级医院糖尿病患者糖尿病足并发症的筛查实践与风险因素DOI: 10.4103/jfmpc.jfmpc_1899_25
Med J Islam Repub IranVolume 39, Issue No.136Plasma sFRP4 Levels and Their Relationship with HOMA IR in Women with Gestational Diabetes Mellitus妊娠期糖尿病女性血浆sFRP4水平及其与HOMA-IR的关系DOI: 10.47176/mjiri.39.129
J Reprod Infant Psychol IF: 01.600Ahead of Print.No.137Breastfeeding, gestational diabetes and maternal distress in Iran: findings from the PERSIAN cohort伊朗母乳喂养、妊娠期糖尿病与产妇心理困扰：PERSIAN队列研究结果DOI: 10.1080/02646838.2026.2662667
International health IF: 02.200Ahead of Print.No.138Feasibility and outcomes of diabetes mellitus screening in people with tuberculosis in Burundi布隆迪结核病患者糖尿病筛查的可行性与结果DOI: 10.1093/inthealth/ihag036
Immunology and cell biology IF: 03.000Ahead of Print.No.139Appetite for destruction: dietary lipids tune the ferroptotic threshold of adaptive immunity破坏的欲望：膳食脂质调节适应性免疫的铁死亡阈值DOI: 10.1111/imcb.70119
J Family Med Prim Care IF: 01.000Volume 15, Issue 2No.140A study on assessment of risk factors for non-communicable diseases in adopted families under family adoption programme - A community - based cross-sectional study家庭收养计划下收养家庭非传染性疾病危险因素评估研究——一项基于社区的横断面研究DOI: 10.4103/jfmpc.jfmpc_836_25
J Family Med Prim Care IF: 01.000Volume 15, Issue 2No.141Hemostatic imbalances in chronic kidney disease: A regional perspective from Bihar慢性肾脏病中的止血失衡：来自比哈尔邦的区域视角DOI: 10.4103/jfmpc.jfmpc_830_25
Health science reports IF: 02.100Volume 9, Issue 4No.142Adult Women's Height and Non-Communicable Disease Risk in Sub-Saharan Africa: A Cross-Sectional Analysis of Demographic and Health Surveys撒哈拉以南非洲成年女性身高与非传染性疾病风险：基于人口与健康调查的横断面分析DOI: 10.1002/hsr2.72413
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.143Editorial: Endocrine regulation of homeostasis of water, electrolytes and organic solutes社论：水、电解质和有机溶质稳态的内分泌调节DOI: 10.3389/fendo.2026.1826713
JID innovationsVolume 6, Issue 3No.144Local IgG autoantibody profiles in hidradenitis suppurativa and their associations with disease features and anti-TNF therapy化脓性汗腺炎局部IgG自身抗体谱及其与疾病特征和抗TNF治疗的关系DOI: 10.1016/j.xjidi.2026.100467
Respirology case reports IF: 00.800Volume 14, Issue 3No.145Sodium Glucose-Like Co-Transporter 2 Inhibitor (SGLT2i) Use in Adults With Cystic Fibrosis钠-葡萄糖协同转运蛋白2抑制剂在成人囊性纤维化中的应用DOI: 10.1002/rcr2.70533
JCEM case reportsVolume 4, Issue 5No.146Complete glucocorticoid resistance: a lethal disorder in the neonatal period完全性糖皮质激素抵抗：新生儿期致死性疾病DOI: 10.1210/jcemcr/luag079
Am J Physiol Heart Circ Physiol IF: 04.100Ahead of Print.No.147Inflammation-Autonomic Crosstalk Contributes to Left Ventricular Diastolic Dysfunction in Type 2 Diabetes: A Rationale for Neuromodulation炎症-自主神经串扰在2型糖尿病左心室舒张功能障碍中的作用：神经调控的理论基础DOI: 10.1152/ajpheart.01006.2025
J Family Med Prim Care IF: 01.000Volume 15, Issue 2No.148SCORE2-diabetes vs SCORE for evaluation of cardiovascular risk in diabetic patientsSCORE2-糖尿病与SCORE在糖尿病患者心血管风险评估中的比较DOI: 10.4103/jfmpc.jfmpc_663_25
J Family Med Prim Care IF: 01.000Volume 15, Issue 2No.149Saudi family physician's clinical inertia of type 2 diabetes management沙特家庭医生在2型糖尿病管理中的临床惰性DOI: 10.4103/jfmpc.jfmpc_238_25
J Family Med Prim Care IF: 01.000Volume 15, Issue 2No.150Performance of Indian diabetic risk score in identifying the undiagnosed type-2 diabetes mellitus among the rural population of Dehradun印度糖尿病风险评分在德拉敦农村人群中识别未诊断2型糖尿病的表现DOI: 10.4103/jfmpc.jfmpc_913_25
J Family Med Prim Care IF: 01.000Volume 15, Issue 2No.151Prevalence and management of renal impairment in adults with type 2 diabetes mellitus in general versus specialized diabetes clinics in primary care in Kingdom of Bahrain巴林王国初级保健中普通诊所与糖尿病专科诊所对2型糖尿病成人患者肾功能损害的患病率和管理比较DOI: 10.4103/jfmpc.jfmpc_440_25
Health science reports IF: 02.100Volume 9, Issue 3No.152Prevalence and Risk Factors for Diabetic Peripheral Neuropathy Among Malagasy Patients With Type 2 Diabetes Mellitus: A Cross-Sectional Study马达加斯加2型糖尿病患者糖尿病周围神经病变的患病率及危险因素：一项横断面研究DOI: 10.1002/hsr2.72209
Case reports in orthopedics IF: 00.600Volume 2026, Issue No.153Primary Pyomyositis of the Adductor and Pectineus Muscle in Patients With Uncontrolled Diabetes: Report of Two Cases未控制糖尿病患者内收肌和耻骨肌原发性化脓性肌炎：两例报告DOI: 10.1155/cro/6657339
Med J Islam Repub IranVolume 39, Issue No.154Economic Evaluation of Sodium-Glucose Cotransporter-2 Inhibitors in Patients with Heart Failure with Preserved or Mildly Reduced Ejection Fraction: A Systematic Review钠-葡萄糖协同转运蛋白2抑制剂在射血分数保留或轻度降低的心力衰竭患者中的经济学评价：系统综述DOI: 10.47176/mjiri.39.161
Renal failure IF: 03.000Volume 48, Issue 1No.155Dapagliflozin improves hemoglobin and anemia in chronic kidney disease: a systematic review and meta-analysis达格列净改善慢性肾脏病患者血红蛋白和贫血：系统评价与荟萃分析DOI: 10.1080/0886022X.2026.2636407
Critical care IF: 09.300Volume 30, Issue 1No.156Expanding awareness of potentially life‑threatening adverse effects of metformin扩大对二甲双胍潜在致命不良反应的认识DOI: 10.1186/s13054-026-06001-0
BMC oral health IF: 03.100Ahead of Print.No.157Diabetes is associated with elevated mortality, stroke, and osteoradionecrosis in squamous cell carcinomas of the head and neck: a systematic review and meta-analysis糖尿病与头颈部鳞状细胞癌死亡率、卒中和骨放射性坏死风险升高相关：系统综述与荟萃分析DOI: 10.1186/s12903-026-08366-8
Clin Exp Hepatol IF: 01.700Volume 11, Issue 3No.158Three-year outcomes under pemafibrate therapy in patients with metabolic dysfunction-associated steatotic liver disease: a long-term observational study佩玛贝特治疗代谢功能障碍相关脂肪性肝病患者的三年结局：一项长期观察性研究DOI: 10.5114/ceh.2025.154217
Curēus IF: 01.300Volume 18, Issue 3No.159Takotsubo Syndrome Mimicking Acute Myocardial Infarction: A Case Report类似急性心肌梗死的Takotsubo综合征：一例病例报告DOI: 10.7759/cureus.105641
J Family Med Prim Care IF: 01.000Volume 15, Issue 2No.160Prevalence of health issues among youth in Kolar - findings from a large-scale population-based cross-sectional study科拉尔地区青少年健康问题患病率——一项大规模人群横断面研究结果DOI: 10.4103/jfmpc.jfmpc_868_25
J Family Med Prim Care IF: 01.000Volume 15, Issue 2No.161Liver benefits of early initiation of low-dose GLP-1 receptor agonists in newly diagnosed type 2 diabetes - A case report新诊断2型糖尿病早期启用低剂量GLP-1受体激动剂的肝脏获益：一例病例报告DOI: 10.4103/jfmpc.jfmpc_1596_25
J Family Med Prim Care IF: 01.000Volume 15, Issue 2No.162Osteoarthritis in Saudi Arabia: Unveiling misconceptions and societal determinants of disease interpretation沙特阿拉伯骨关节炎：揭示疾病解读中的误解与社会决定因素DOI: 10.4103/jfmpc.jfmpc_1205_25
J Family Med Prim Care IF: 01.000Volume 15, Issue 2No.163Effectiveness of school-based intervention in obese children学校干预对肥胖儿童的有效性DOI: 10.4103/jfmpc.jfmpc_1909_24
Contemp Clin Trials Commun IF: 01.400Volume 51, Issue No.164Mechanistic study of inspiratory training in childhood Asthma: Rationale and methods of a pediatric clinical trial儿童哮喘吸气训练的机制研究：一项儿科临床试验的原理与方法DOI: 10.1016/j.conctc.2026.101638
Clinicoecon Outcomes Res IF: 02.200Volume 18, Issue No.165Healthcare Resource Utilization and the Direct Medical Cost of Fibromyalgia Patients in a Tertiary Hospital in Saudi Arabia沙特阿拉伯一家三级医院纤维肌痛患者的医疗资源利用与直接医疗费用DOI: 10.2147/CEOR.S578039
Acta Biochimica Polonica IF: 01.700Volume 73, Issue No.166Genetic architecture of obesity and advances in precision pharmacotherapy: a comprehensive review肥胖的遗传架构与精准药物治疗进展：一项全面综述DOI: 10.3389/abp.2026.15484
Frontiers in sleepVolume 5, Issue No.167Sleep duration and food insecurity among minority urban college students: predictors of health and academic disparity少数族裔城市大学生睡眠时长与食物不安全：健康与学业差异的预测因素DOI: 10.3389/frsle.2026.1759416
Public health challengesVolume 5, Issue 1No.168Leveraging the Positive Deviance Approach to Drive Behavior Change in Noncommunicable Diseases: A Scoping Review利用正向偏差方法推动非传染性疾病行为改变：一项范围综述DOI: 10.1002/puh2.70074
Curēus IF: 01.300Volume 18, Issue 3No.169Tackling Obesity: A Qualitative Exploration of a Whole School Food Policy Guideline应对肥胖：一项关于全校食品政策指南的定性探索DOI: 10.7759/cureus.105629
Curēus IF: 01.300Volume 18, Issue 3No.170Gestational Obstructive Sleep Apnea: From Pathophysiological Mechanisms to Maternal-Fetal Outcomes妊娠期阻塞性睡眠呼吸暂停：从病理生理机制到母胎结局DOI: 10.7759/cureus.105659
Health science reports IF: 02.100Volume 9, Issue 3No.171Critical Evaluation of the Impact of COVID-19 Pandemic on Child Health and Wellbeing and Suggested Preparedness for Future Pandemics-A Narrative ReviewCOVID-19大流行对儿童健康与福祉影响的批判性评估及未来大流行防范建议——一项叙述性综述DOI: 10.1002/hsr2.72073
Health science reports IF: 02.100Volume 9, Issue 3No.172Correlation Between Coagulopathy and Glycemic Control Among People With Type 2 Diabetes Mellitus in the Southwestern Cameroon, a Cross-Sectional Study喀麦隆西南部2型糖尿病患者凝血功能障碍与血糖控制的相关性：一项横断面研究DOI: 10.1002/hsr2.72128
Health science reports IF: 02.100Volume 9, Issue 3No.173Assessment of Lifestyle and Dietary Patterns Among Students at the University of Human Development in Sulaimani City: A Cross-Sectional Study 2025-2026苏莱曼尼亚人类发展大学学生生活方式与膳食模式评估：一项横断面研究（2025-2026）DOI: 10.1002/hsr2.72125
Frontiers in nutrition IF: 05.100Volume 13, Issue No.174Dietary diversity, nutrition knowledge and attitude among adolescents in Addis Ababa: a cross-sectional study亚的斯亚贝巴青少年膳食多样性、营养知识与态度：一项横断面研究DOI: 10.3389/fnut.2026.1696811
Frontiers in oncology IF: 03.300Volume 16, Issue No.175Predictors of sentinel lymph node mapping failure in endometrial cancer: a retrospective multicenter study子宫内膜癌前哨淋巴结显像失败的预测因素：一项回顾性多中心研究DOI: 10.3389/fonc.2026.1799692
Australian prescriber IF: 04.200Volume 49, Issue 2No.176Metabolic dysfunction-associated fatty liver disease: an update代谢功能障碍相关脂肪性肝病：最新进展DOI: 10.18773/austprescr.2026.014
Obesity pillarsVolume 18, Issue No.177Sarcopenic obesity in type 2 diabetes: An underrecognized clinical challenge2型糖尿病中的肌少性肥胖：一个未被充分认识的临床挑战DOI: 10.1016/j.obpill.2026.100270
IJU case reports IF: 00.600Volume 9, Issue 2No.178Delayed Clinical Manifestation of Malignant Potential in a Cortisol-Secreting Adrenal Tumor Initially Diagnosed as Adenoma最初诊断为腺瘤的皮质醇分泌性肾上腺肿瘤恶性潜能的延迟临床表现DOI: 10.1002/iju5.70166
Lancet Reg Health West Pac IF: 08.100Volume 69, Issue No.179Country-specific modifiable dementia risk factors across the Western Pacific Region determined by population attributable fraction西太平洋地区各国可改变痴呆风险因素的人群归因分数分析DOI: 10.1016/j.lanwpc.2026.101857
Saudi journal of anaesthesiaVolume 20, Issue 2No.180Cauda equina syndrome in an obese parturient following cesarean section under combined spinal-epidural anesthesia肥胖产妇在腰硬联合麻醉下剖宫产后发生马尾综合征DOI: 10.4103/sja.sja_822_25
Ophthalmology science IF: 04.600Volume 6, Issue 5No.181Genetic and Phenotypic Characterization of a Large Cohort of Patients with BBS1-RetinopathyBBS1相关视网膜病变患者大型队列的遗传与表型特征分析DOI: 10.1016/j.xops.2026.101164
Ophthalmology science IF: 04.600Volume 6, Issue 5No.182Retinomics as a Tool for Glaucoma Prediction视网膜组学作为青光眼预测工具DOI: 10.1016/j.xops.2026.101163
Clin Exp Hepatol IF: 01.700Volume 11, Issue 4No.183Diagnosing and treating fatty liver disease: strategies for hepatocellular carcinoma and cardiovascular disease prevention脂肪性肝病的诊断与治疗：肝细胞癌与心血管疾病预防策略DOI: 10.5114/ceh.2025.155228
Clin Exp Hepatol IF: 01.700Volume 11, Issue 4No.184Metabolic dysfunction-associated steatotic liver disease in children儿童代谢功能障碍相关脂肪性肝病DOI: 10.5114/ceh.2025.155319
Med J Islam Repub IranVolume 39, Issue No.185Symptom Severity and Duration of COVID-19 Are Correlated with the Healthy Eating Index (HEI) Among Hospitalized Elderly Patients住院老年COVID-19患者症状严重程度和病程与健康饮食指数的相关性DOI: 10.47176/mjiri.39.142
Med J Islam Repub IranVolume 39, Issue No.186The Iranian Consensus on Self-Monitoring of Blood Glucose: An Expert Consensus伊朗自我血糖监测共识：专家共识DOI: 10.47176/mjiri.39.147
Med J Islam Repub IranVolume 39, Issue No.187Efficacy of Topical Chamomile and Dill Oil on Abdominal Obesity in Women Ages 25-55 Years: A Randomized Clinical Trial局部洋甘菊和莳萝油对25-55岁女性腹型肥胖的有效性：一项随机临床试验DOI: 10.47176/mjiri.39.155
Clinical nephrology IF: 01.000Ahead of Print.No.188Evaluation of epicardial adipose tissue in children with chronic kidney disease慢性肾脏病儿童心外膜脂肪组织的评估DOI: 10.5414/CN111925
Am J Physiol Renal Physiol IF: 03.400Ahead of Print.No.189Endogenous oxalate synthesis in mouse models of metabolic dysfunction-associated steatotic liver disease代谢功能障碍相关脂肪性肝病小鼠模型中的内源性草酸合成DOI: 10.1152/ajprenal.00308.2025
Journal of medical economics IF: 03.000Volume 29, Issue 1No.190Enhancing economic modelling in obesity: integrating novel type 2 diabetes progression & obstructive sleep apnea remission - a UK case study肥胖经济模型优化：整合新型2型糖尿病进展与阻塞性睡眠呼吸暂停缓解——英国案例研究DOI: 10.1080/13696998.2026.2646079
Kaohsiung J Med Sci IF: 03.100Ahead of Print.No.191Impact of Cardiometabolic Risk Factors and Steatotic Liver Disease on Liver-Related Outcomes in Patients With Chronic Hepatitis C After Curative Antiviral Therapy心脏代谢危险因素和脂肪性肝病对慢性丙型肝炎患者治愈性抗病毒治疗后肝脏相关结局的影响DOI: 10.1002/kjm2.70214
J Nepal Health Res CouncVolume 23, Issue 4No.192Association of Salt Taste Sensitivity Threshold with Blood Pressure and Obesity Indicators among Healthy Young Adults健康年轻成人咸味敏感阈值与血压及肥胖指标的关系DOI: 10.33314/jnhrc.v23i04.4727
BMC musculoskeletal disorders IF: 02.400Ahead of Print.No.193Does body mass index independently affect functional outcomes after conservatively treated distal radius fractures? a retrospective cohort study体重指数是否独立影响保守治疗后桡骨远端骨折的功能结局？一项回顾性队列研究DOI: 10.1186/s12891-026-09879-7
Journal of medical investigation IF: 00.700Volume 73, Issue 1.2No.194Key Biomarkers and Physical Performance Indicators Associated with Pre-Frailty and Frailty in Patients with Chronic Schizophrenia aged < 65 years慢性精神分裂症患者（年龄<65岁）中与衰弱前期和衰弱相关的关键生物标志物及身体表现指标DOI: 10.2152/jmi.73.12
Nihon kōshū eisei zasshiAhead of Print.No.195[Utilizing administrative data to enhance the Health Management Support Program for public assistance recipients aged <40 years: Lessons from Toyonaka City]利用行政数据加强针对40岁以下公共援助受助者的健康管理支持计划：来自丰中市的经验DOI: 10.11236/jph.25-107
The American journal of nursing IF: 02.000Volume 126, Issue 5No.196Rapid weight regain after discontinuation of weight management medications停用体重管理药物后快速体重反弹DOI: 10.1097/AJN.0000000000000300c
J Family Med Prim Care IF: 01.000Volume 15, Issue 2No.197Knowledge and awareness about microvascular complications of diabetes mellitus among Taif University medical students塔伊夫大学医学生对糖尿病微血管并发症的认知与意识DOI: 10.4103/jfmpc.jfmpc_1457_25
Int J Nanomedicine IF: 06.500Volume 21, Issue No.198Calcium Carbonate-Stabilized Nano-Caffeine Emulsion Attenuates Diabetic Cardiomyopathy via Antioxidant, Anti-Inflammatory, and Anti-Fibrotic Pathways in Type 2 Diabetic Rats with HPLC-Quantified Cardiac Caffeine Levels碳酸钙稳定的纳米咖啡因乳液通过抗氧化、抗炎和抗纤维化途径减轻2型糖尿病大鼠糖尿病心肌病并伴有HPLC定量心脏咖啡因水平DOI: 10.2147/IJN.S573949
Clin Exp Hepatol IF: 01.700Volume 11, Issue 4No.199Potential pharmacotherapy pathways in metabolic dysfunction-associated steatotic liver disease代谢功能障碍相关脂肪性肝病的潜在药物治疗路径DOI: 10.5114/ceh.2025.154956
J Nepal Health Res CouncVolume 23, Issue 4No.200Prevalence and Predictors of Glycemic Control among Diabetic Patients in in Lalitpur, Nepal尼泊尔拉利特普尔糖尿病患者血糖控制现状及预测因素DOI: 10.33314/jnhrc.v23i04.4696
The Nurse practitioner IF: 00.900Volume 51, Issue 5No.201GLP-1 receptor agonists: The good, the bad, and the ugly-A comprehensive guide for NPsGLP-1受体激动剂：好、坏与丑——执业护士综合指南DOI: 10.1097/01.NPR.0000000000000430
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.202Gene Therapy and Gene Editing in Type 1 Diabetes: CRISPR-Based β-Cell Replacement and Treg Immune Modulation Approaches1型糖尿病的基因治疗与基因编辑：基于CRISPR的β细胞替代和Treg免疫调节方法DOI: 10.1111/dom.70800
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.203Integrated miRNA-mRNA Analysis Reveals Obesity-Driven Regulatory Networks in Human Visceral Adipose Tissue With and Without Type 2 Diabetes整合miRNA-mRNA分析揭示肥胖驱动的人内脏脂肪组织调控网络：伴或不伴2型糖尿病DOI: 10.1111/dom.70787
J Family Med Prim Care IF: 01.000Volume 15, Issue 2No.204The effect of fasting Ramadan on type 2 diabetes: A narrative review and practice update斋月禁食对2型糖尿病的影响：叙述性综述与实践更新DOI: 10.4103/jfmpc.jfmpc_1118_25
J Family Med Prim Care IF: 01.000Volume 15, Issue 2No.205When type 1 diabetes isn't the answer: A case series of siblings with misdiagnosed diabetes mellitus later confirmed as maturity-onset diabetes of the young当1型糖尿病不是答案：一例被误诊为糖尿病的兄弟姐妹后确诊为青少年起病的成人型糖尿病的病例系列DOI: 10.4103/jfmpc.jfmpc_1747_25
J Family Med Prim Care IF: 01.000Volume 15, Issue 2No.206A case of once-weekly basal insulin therapy for a dementia patient with Type 2 Diabetes mellitus and living alone每周一次基础胰岛素治疗独居痴呆合并2型糖尿病患者的病例报告DOI: 10.4103/jfmpc.jfmpc_1936_25
Frontiers in medicine IF: 03.000Volume 13, Issue No.207Biologics and biosimilars medication errors in Saudi Arabia: a nationwide retrospective observational real-world study沙特阿拉伯生物制剂与生物类似药用药错误：一项全国性回顾性观察性真实世界研究DOI: 10.3389/fmed.2026.1795867
Chronic Dis Transl MedVolume 12, Issue 1No.208Exploring the Anti-Diabetic Potential of Anthocyanins: From Biochemical Pathways to Human Trials探索花青素的抗糖尿病潜力：从生化途径到人体试验DOI: 10.1002/cdt3.70033
Respirology case reports IF: 00.800Volume 14, Issue 3No.209Cystic Fibrosis-Related Diabetes and Celiac Disease in a Paediatric CF Patient: Presence of CFRD-Associated SNPs rs7903146 (TT) and rs4077468 (GG)儿童囊性纤维化患者中囊性纤维化相关糖尿病与乳糜泻共存：CFRD相关SNP rs7903146（TT）和rs4077468（GG）的存在DOI: 10.1002/rcr2.70551
JCEM case reportsVolume 4, Issue 5No.210Early GH therapy and neurodevelopmental outcome in a child with compound heterozygous IGF1R variants早期GH治疗对复合杂合IGF1R变异儿童神经发育结局的影响DOI: 10.1210/jcemcr/luag081
Clin Exp Hepatol IF: 01.700Volume 11, Issue 3No.211Recommendations for hypolipidemic and antithrombotic therapy in HCV-infected patients treated with direct-acting antiviral agents: expert position statement直接抗病毒药物治疗的丙型肝炎病毒感染患者降脂和抗血栓治疗建议：专家立场声明DOI: 10.5114/ceh.2025.154978
J Nutr Metab IF: 02.400Volume 2026, Issue No.212The Safety Profile of Aspartame: A Review of Regulatory Standards and Emerging Health Concerns阿斯巴甜的安全性：监管标准与新兴健康问题综述DOI: 10.1155/jnme/4727546
J Clin Exp Hepatol IF: 03.200Volume 16, Issue 4No.213Sex Differences in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): Epidemiology, Pathophysiology, and Clinical Implications代谢功能障碍相关脂肪性肝病的性别差异：流行病学、病理生理学及临床意义DOI: 10.1016/j.jceh.2026.103533
Saudi journal of anaesthesiaVolume 20, Issue 2No.214Anesthesia considerations in pediatric pancreatectomy for congenital hyperinsulinemic hypoglycemia: A retrospective case series先天性高胰岛素血症低血糖患儿胰腺切除术的麻醉考量：一项回顾性病例系列研究DOI: 10.4103/sja.sja_869_25
Plast Reconstr Surg Glob Open IF: 01.800Volume 14, Issue 4No.215Craniofacial Fracture and Secretome: A Systematic Review颅面骨折与分泌组：一项系统综述DOI: 10.1097/GOX.0000000000007482
Canadian journal of zoologyVolume 104, Issue No.216Hibernation-Inspired Innovations in Biomedicine: Addressing Aging, Chronic Diseases, and Critical Care冬眠启发的生物医学创新：应对衰老、慢性疾病和重症监护DOI: 10.1139/cjz-2025-0055
Circulation Research IF: 16.200Ahead of Print.No.217Endothelial NOX1 Drives Obesity via Skeletal Muscle Mitochondrial Dysfunction内皮NOX1通过骨骼肌线粒体功能障碍驱动肥胖DOI: 10.1161/CIRCRESAHA.125.326768
J Biochem Mol Toxicol IF: 02.800Volume 40, Issue 5No.218Melatonin and Quercetin Co-Treatment Attenuates Hepatic Damage in Diabetic Rats by Mitigating Oxidative Stress and Inflammation褪黑素和槲皮素联合治疗通过减轻氧化应激和炎症缓解糖尿病大鼠的肝脏损伤DOI: 10.1002/jbt.70855
Lipids in health and disease IF: 04.200Ahead of Print.No.219Untargeted plasma lipidomic profiling associated with pediatric metabolic dysfunction-associated steatohepatitis (MASH)非靶向血浆脂质组学分析在儿童代谢功能障碍相关脂肪性肝炎（MASH）中的应用DOI: 10.1186/s12944-026-02937-y
Journal of medical investigation IF: 00.700Volume 73, Issue 1.2No.220Sex differences in the impact of structured education together with isCGM in individuals with type 1 diabetes:post hoc analysis of the ISCHIA study1型糖尿病患者中结构化教育与间歇性扫描持续葡萄糖监测联合干预效果的性别差异：ISCHIA研究的事后分析DOI: 10.2152/jmi.73.74
Journal of medical investigation IF: 00.700Volume 73, Issue 1.2No.221Effect of glucose load on metabolism in patients with type 2 diabetes during elective surgery using remifentanil-induced anesthesia:a randomized controlled trial葡萄糖负荷对瑞芬太尼麻醉下择期手术2型糖尿病患者代谢的影响：一项随机对照试验DOI: 10.2152/jmi.73.222
JAAD case reportsVolume 71, Issue No.222Treatment of recurrent facial ulcerations and dysesthesias from trigeminal trophic syndrome with chronic transcutaneous vagus nerve stimulation慢性经皮迷走神经刺激治疗三叉神经营养综合征引起的复发性面部溃疡和感觉异常DOI: 10.1016/j.jdcr.2026.03.035
Health science reports IF: 02.100Volume 9, Issue 3No.223Adherence to Insulin Treatment in People With Type 1 or Type 2 Diabetes in Primary Health Care in a Brazilian City: A Cross-Sectional Study巴西某城市初级卫生保健中1型或2型糖尿病患者胰岛素治疗依从性的横断面研究DOI: 10.1002/hsr2.72105
Current eye research IF: 02.000Ahead of Print.No.224Intraocular Distribution and Aqueous-Vitreous Correlation of TGF-β Isoforms and GDF-15 in Retinal Diseases视网膜疾病中TGF-β亚型与GDF-15的眼内分布及房水-玻璃体相关性DOI: 10.1080/02713683.2026.2660821
Annals of African medicine IF: 00.600Ahead of Print.No.225Real-world Impact of Antivascular Endothelial Growth Factor Treatment on Visual and Anatomical Outcomes in Diabetic Macular Edema: A Prospective Observational Study抗血管内皮生长因子治疗对糖尿病性黄斑水肿视觉和解剖学结局的真实世界影响：一项前瞻性观察研究DOI: 10.4103/aam.aam_751_25
IbrainVolume 12, Issue 1No.226RETRACTED: Clinical effectiveness and treatment satisfaction between two triple-therapy regimens in treating neuropathic pain: A real-world data两种三联疗法治疗神经病理性疼痛的临床有效性和治疗满意度：一项真实世界数据研究DOI: 10.1002/ibra.12143
Kidney medicine IF: 03.400Volume 8, Issue 5No.227Gabapentin Utilization and Adverse Effects Among US Hemodialysis Patients Diagnosed With Pruritus or Neuropathic Pain美国血液透析患者中加巴喷丁的使用与不良事件：基于瘙痒或神经病理性疼痛诊断的分析DOI: 10.1016/j.xkme.2026.101341
Res Pract Thromb Haemost IF: 03.400Volume 10, Issue 3No.228Cathepsin G is associated with cerebral vascular injury in myeloid leukemia: a pathologic insight into intracranial hemorrhage组织蛋白酶G与髓系白血病脑血管损伤相关：颅内出血的病理学新见解DOI: 10.1016/j.rpth.2026.103433
Frontiers in medicine IF: 03.000Volume 13, Issue No.229Strengths and limitations of HFpEF probability scores in the era of precision medicine精准医学时代射血分数保留的心力衰竭概率评分的力量与局限DOI: 10.3389/fmed.2026.1799451
Current nutrition reports IF: 05.500Volume 15, Issue 1No.230Comparative Analysis of Adipokines and Growth Factors in Preterm and Term Breast Milk and Their Role in Infant Growth早产与足月母乳中脂肪因子和生长因子的比较分析及其在婴儿生长中的作用DOI: 10.1007/s13668-026-00758-0
Pregnancy Hypertension IF: 02.900Volume 44, Issue No.231Self-reported primary preventive follow-up of women’s cardiovascular health after hypertensive pregnancy complications and gestational diabetes妊娠期高血压并发症和妊娠期糖尿病后女性心血管健康自我报告的一级预防随访DOI: 10.1016/j.preghy.2026.101474
200
Diabetes Mellitus(DM)
糖尿病
102
Obesity
肥胖症
65
Insulin
胰岛素
31
Type 2 diabetes mellitus(T2DM)
2型糖尿病
11
Diabetic Retinopathy
糖尿病视网膜病
9
Diabetic Foot
糖尿病足
9
Metabolic Syndrome
代谢综合征
7
Metformin
二甲双胍
7
Semaglutide
司美格鲁肽
6
Gestational Diabetes Mellitus(GDM)
妊娠糖尿病
6
Diabetes Complications
糖尿病并发症
5
Type 1 diabetes mellitus(T1DM)
1型糖尿病
5
Glucagon-Like Peptide-1 Receptor Agonists(GLP-1RA)
胰高血糖素样肽-1受体激动剂
4
Hypoglycemic Agents
降糖药
4
Diabetic acidosis
糖尿病性酸中毒
4
Diabetic Kidney Disease(DKD)
糖尿病肾脏病
3
Empagliflozin
恩格列净
3
Diabetic Neuropathies
糖尿病性神经病变
3
Gabapentin
加巴喷丁
3
Tirzepatide
替尔泊肽
2
Dulaglutide
度拉糖肽
2
Liraglutide
利拉鲁肽
2
Dipeptidyl-Peptidase IV Inhibitors(DPP-4i)
二肽基肽酶-4抑制剂
2
Pregabalin
普瑞巴林
2
Diabetic Cardiomyopathies
糖尿病心肌病
2
Dapagliflozin
达格列净
1
Ertugliflozin
艾托格列净
1
Diabetic Peripheral Neuropathy(PDN)
糖尿病周围神经病变
1
Alogliptin
阿格列汀
1
Lixisenatide
利司那肽
1
Exenatide
艾塞那肽
1
Sodium-Glucose Transporter 2 Inhibitors(SGLT-2i)
钠-葡萄糖协同转运蛋白2抑制剂
编辑：韩玉莲
审校：韩玉莲
2026-04-24
编者按：在糖尿病管理领域，我们从未停止对更优血糖控制指标的探索。长久以来，糖化血红蛋白（HbA1c）作为评估长期血糖控制的“金标准”，在临床中扮演着重要角色，但该指标仅反映平均血糖水平，无法体现血糖波动特征——相同HbA1c背后，患者的血糖谱与并发症风险可能差异显著。随着临床认知的深化和持续葡萄糖监测（CGM）技术的临床普及，一个更全面、更精准的指标——葡萄糖目标范围内时间（TIR）正从研究前沿走向临床日常，推动控糖理念从“单纯控糖”向“平稳控糖”范式升级。
那么，如何有效提升TIR？餐后血糖（PPG）在其中发挥着怎样的核心作用？本期特邀复旦大学附属中山医院李小英教授和浙江大学医学院附属邵逸夫医院周嘉强教授，深度萃取TIR的临床应用价值，探讨从HbA1c到TIR的演变逻辑，同时结合临床证据，共话从PPG管理到TIR 达标的实践路径。
读懂TIR
血糖管理的“新语言”
在全面控糖时代，精准诊疗的前提是掌握核心术语。这些指标共同构成了基于CGM的血糖评价体系：
TIR之所以被称为血糖管理的“新语言”，在于它弥补了传统指标HbA1c的“盲区”。HbA1c虽为评估长期血糖控制的“金标准”[4]，却无法反映即刻血糖水平，也难以揭示血糖波动的真实状况[4]。相同HbA1c水平的患者，其血糖谱可能天差地别：一人血糖平稳，另一人则可能经历剧烈的血糖波动[5]。而高血糖波动通过多重机制，显著增加糖尿病并发症风险[6]。血糖对机体的损害来自两方面：一是血糖的绝对水平（可由HbA1c衡量），二是血糖的波动。后者通过氧化应激、内质网应激等机制造成器官损伤，这正是我们在控制HbA1c的同时必须关注血糖波动的病理生理基础。TIR 恰恰填补了这一评估缺位，让控糖更有“颗粒度”。
从“金标准”到“新标准”
TIR何以成为指南新宠？
基于对血糖波动的精准评估价值，TIR已被国内外权威指南明确列为血糖控制的有效指标。《中国糖尿病防治指南（2024版）》明确指出，TIR是评价血糖控制的有效指标，推荐大多数1型及2型糖尿病（T2DM）患者将TIR控制目标设定为＞70%[4]。美国糖尿病学会（ADA）指南同样强调，对于大多数使用CGM的非妊娠成年人来说，将TIR设定为＞70%是合适的目标[7]。这一变迁，折射出糖尿病管理理念的深刻变革：从宏观的“控糖”走向精细化的“稳糖”。
TIR不仅能精细化反映血糖波动，也被证实与远期临床结局强相关。DEVOTE研究事后分析显示，dTIR越高，首次发生主要不良心血管事件（MACE）、微血管事件的风险越低[8]。一项纳入6225例T2DM患者、中位随访6.9年的研究证实，TIR减少与全因死亡风险增加显著相关[9]。此外，卫生经济学研究亦表明，TIR越高，患者20年内的医疗成本越低、质量调整生命年（QALY）越高[10]。
然而，尽管TIR的临床价值明确，但临床实践中超过50%的T2DM患者TIR未能达标[9]，主要表现为TAR偏高。深入分析发现，TAR的升高很大程度上源于PPG的控制不佳[11]。人体全天约有超过16小时处于餐后状态，餐后高血糖成为推高TAR、拉低TIR的关键因素。更值得关注的是，当TIR接近达标时，PPG对TIR的相对贡献更大[11]。这意味着，在精细化管理阶段，PPG管理对于TIR的进一步提升具有重要价值。传统的“基础胰岛素”或“单药OAD”往往难以同时兼顾空腹血糖（FPG）与PPG，因此，聚焦PPG管理，是提升TIR、实现血糖优质达标的关键突破口，也凸显了双效协同方案的必要性。
甘精利司
双效协同，如何实现“全天稳糖”？
01
机制协同，直击核心
面对PPG管理的难点，理想的降糖方案应能同时兼顾FPG与PPG，实现“全天覆盖”与“精准控糖”。创新固定比例复方制剂（FRC）甘精胰岛素利司那肽（简称甘精利司），正是基于这一理念而生[12]。甘精利司的两种组分实现机制互补：
甘精胰岛素：通过模拟生理性胰岛素分泌，持续24小时稳定提供基础胰岛素[13]，有效控制FPG；
利司那肽：通过葡萄糖依赖性促进胰岛素释放、抑制胰高血糖素分泌、延缓胃排空，强效控制PPG漂移，且最大限度地降低治疗相关的低血糖风险[13]。
二者联用，能够精准针对T2DM患者β细胞功能障碍和胰岛素抵抗两大核心缺陷[14]，实现FPG与PPG的同时控制，为提升TIR奠定了坚实的药理学基础。
02
证据引领，TIR显著提升
多项临床研究证实了甘精利司可在多种治疗背景下提升TIR，实现平稳控糖：
综合上述研究可见，甘精利司在不同治疗背景下均可使dTIR达到78%以上，高于指南推荐的70%标准。其中，OADs控制不佳患者的dTIR提升最为显著（可达85.9%），提示该方案在起始注射治疗阶段具有突出优势。这些数据有力证明，无论患者既往接受何种治疗方案，转换为甘精利司均可有效提升TIR，实现更平稳、更安全的血糖控制。
此外，临床实践中还观察到，FRC能够显著减少患者的注射次数（如从预混胰岛素的每日2次减为每日1次），这不仅降低了治疗负担，也使患者从“病人状态”回归到更接近正常生活的心理状态，对治疗信心的建立和长期依从性的维持具有积极意义。
总 结
从HbA1c的“金标准”到TIR的“新标准”，我们见证了糖尿病血糖管理走向关注全天候血糖平稳的“精细化”时代。TIR不仅是一个血糖评估指标，更代表着一种全新的控糖理念——关注每一刻的血糖平稳，追求以远期结局改善为目标的优质达标。在提升TIR的路径中，PPG管理是决定血糖达标率的核心因素之一，而甘精利司复方制剂通过双机制协同，实现了对FPG与PPG的全面覆盖。多项循证证据显示，该方案能显著提升不同治疗背景患者的TIR水平，为实现T2DM患者精准控糖与远期获益提供了简便、高效的临床选择。
参考文献：（上下滑动查看更多）
[1] 中华医学会糖尿病学分会. 中国血糖监测临床应用指南（2021年版）. 中华糖尿病杂志, 2021, 13(10): 936948.
[2] Battelino T, et al. Clinical Targets for Continuous Glucose Monitoring Data Interpretation: Recommendations From the International Consensus on Time in Range. Diabetes Care, 2019, 42(8): 15931603.
[3] Guo X, Yang W, Zhang J, et al. iGlarLixi provides a higher derived time-in-range versus insulin glargine 100 U/mL or lixisenatide in Asian Pacific people with type 2 diabetes: A post hoc analysis. Diabetes Obes Metab. 2023;25(7):2005-2011. doi:10.1111/dom.15074IF: 5.7 Q1
[4] 中华医学会糖尿病学分会. 中国糖尿病防治指南（2024版）. 中华糖尿病杂志, 2025, 17(01): 16139.
[5] Kovatchev B, et al. Quantifying temporal glucose variability in diabetes via continuous glucose monitoring: mathematical methods and clinical application. Diabetes Care, 2016, 39(4): 502510.
[6] Shen, Y., Dai, D., Lu, J. et al. Visit-to-visit variability of glycated albumin was associated with incidence or progression of lower extremity atherosclerotic disease. Cardiovasc Diabetol 19, 211 (2020). https://doi.org/10.1186/s12933-020-01187-1IF: 10.6 Q1.
[7] American Diabetes Association. Standards of Care in Diabetes—2026. Diabetes Care, 2026, 49(Supplement_1): S1S371.
[8] Bergenstal RM, et al. Increased Derived Time in Range Is Associated with Reduced Risk of Major Adverse Cardiovascular Events, Severe Hypoglycemia, and Microvascular Events in Type 2 Diabetes: A Post Hoc Analysis of DEVOTE Diabetes Technol Ther, 2023, 25(6): 378-383.
[9] Lu J, et al. Time in Range in Relation to AllCause and Cardiovascular Mortality in Patients With Type 2 Diabetes: A Prospective Cohort Study. Diabetes Care, 2021, 44(2): 549555.
[10] Alkhuzam K, et al. Long-term health benefit and economic return of time in range (TIR) improvement in individuals with type 2 diabetes. Diabetes Obes Metab, 2025, 27(3): 1564-1571.
[11] Uemura F, et al. Contribution of Postprandial Glucose to Time in Range in NonInsulinTreated Patients with Type 2 Diabetes. Diabetes Technol Ther, 2022, 24(11): 805813.
[12] 《基础胰岛素/胰升糖素样肽1受体激动剂复方制剂用于治疗2型糖尿病的临床专家建议》编写委员会. 基础胰岛素/胰升糖素样肽1受体激动剂复方制剂用于治疗2型糖尿病的临床专家建议. 中华内分泌代谢杂志, 2023, 39(08): 645650.
[13] Hinnen D, Strong J. iGlarLixi: A New Once-Daily Fixed-Ratio Combination of Basal Insulin Glargine and Lixisenatide for the Management of Type 2 Diabetes. Diabetes Spectr. 2018 May;31(2):145-154. doi: 10.2337/ds17-0014. PMID: 29773934; PMCID: PMC5951239.
[14] Biswas SK, et al. Pathophysiology of Type 2 Diabetes: An Overview. J Diabetes Res, 2015, 2015: 150325.
[15] Liu J, et al. Evaluation of efficacy of iGlarLixi versus IDegAsp using derived time-in-ranges in Chinese adults with Type 2 diabetes: A post hoc analysis of the Soli-D study. Diabetes Obes Metab, 2025, 27(10): 60686071.
[16] Martin Haluzík et al.Efficacy and safety of switching to iGlarLixi from premixed insulins in people with type 2 diabetes: The Soli-SWITCH study.Diabetes Obes Metab. 2025;27:2730–2739.
[17] Haluzík M, et al. Time-in-range derived from self-measured blood glucose in people with type 2 diabetes advancing to iGlarLixi: A participant-level pooled analysis of three phase 3 LixiLan randomized controlled trials. Diabetes Obes Metab, 2024, 26(11): 50465055.
[18] Novodvorský P, et al. Insulin therapy DE-intensificAtion with iGlarLixi: A phase 4, open-label, parallel-group randomised controlled trial. Diabetes Obes Metab, 2025 Dec 15. doi: 10.1111/dom.70362.
声明：本文仅供医疗卫生专业人士了解最新医药资讯参考使用，不代表本平台观点。该等信息不能以任何方式取代专业的医疗指导，也不应被视为诊疗建议，如果该信息被用于资讯以外的目的，本站及作者不承担相关责任。
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 2型糖尿病 | 欧盟 | 2013-01-31 | |
| 2型糖尿病 | 冰岛 | 2013-01-31 | |
| 2型糖尿病 | 列支敦士登 | 2013-01-31 | |
| 2型糖尿病 | 挪威 | 2013-01-31 |
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| 急性冠状动脉综合征 | 临床3期 | 美国 | 2010-06-01 | |
| 急性冠状动脉综合征 | 临床3期 | 中国 | 2010-06-01 | |
| 急性冠状动脉综合征 | 临床3期 | 日本 | 2010-06-01 | |
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| 急性冠状动脉综合征 | 临床3期 | 白俄罗斯 | 2010-06-01 | |
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| 研究 | 分期 | 人群特征 | 评价人数 | 分组 | 结果 | 评价 | 发布日期 |
|---|
临床3期 | - | GLP-1 receptor agonists (GLP-1RAs) | 窪網醖憲構壓壓膚窪鬱(膚膚齋積蓋壓夢鹽遞鹹) = 鑰範繭齋憲夢壓遞齋衊 糧膚顧鑰齋願獵積壓淵 (願鑰餘衊餘齋鏇淵夢蓋 ) | 不佳 | 2025-02-13 | ||
Placebo/non-GLP-1 RA regimens | 窪網醖憲構壓壓膚窪鬱(膚膚齋積蓋壓夢鹽遞鹹) = 艱獵艱築獵遞鹹淵齋醖 糧膚顧鑰齋願獵積壓淵 (願鑰餘衊餘齋鏇淵夢蓋 ) | ||||||
临床2期 | 156 | 繭顧醖遞觸淵廠築膚鑰(鹽鏇窪鹽餘鏇鏇築遞製) = Nausea occurred in 46% of participants receiving lixisenatide 鏇繭糧艱齋網襯製夢網 (範獵壓築廠簾鑰繭鑰網 ) 更多 | 积极 | 2024-04-04 | |||
Placebo | |||||||
临床2期 | 156 | 顧襯鹽淵蓋膚鹽鹽餘繭(壓齋憲襯觸壓鹽顧襯醖) = 夢憲積顧積齋衊網構繭 製壓鹽餘壓獵遞窪顧鏇 (鬱襯糧憲壓鹹夢願壓糧 ) 更多 | 积极 | 2024-04-03 | |||
Placebo | 顧襯鹽淵蓋膚鹽鹽餘繭(壓齋憲襯觸壓鹽顧襯醖) = 襯憲糧製遞糧積壓選簾 製壓鹽餘壓獵遞窪顧鏇 (鬱襯糧憲壓鹹夢願壓糧 ) 更多 | ||||||
临床3期 | - | iGlarLixi | 窪鹹夢觸壓淵繭壓淵壓(鹹鏇醖繭襯憲簾醖遞願): P-Value = 11.45 | - | 2023-03-30 | ||
Glargine 100 U/mL | |||||||
临床3期 | 426 | iGlarLixi | 襯艱襯齋憲繭鑰壓醖選(鏇顧網築壓襯簾獵襯鹹) = 鹹艱齋網顧獵積顧淵齋 糧築廠積餘簾築繭簾顧 (淵範夢醖築繭觸積艱齋 ) 更多 | 优效 | 2022-06-28 | ||
insulin glargine | 襯艱襯齋憲繭鑰壓醖選(鏇顧網築壓襯簾獵襯鹹) = 蓋壓構醖憲鏇艱築觸壓 糧築廠積餘簾築繭簾顧 (淵範夢醖築繭觸積艱齋 ) 更多 | ||||||
STAR.Ro (Pubmed) 人工标引  | N/A | 901 | 鹽醖淵淵艱窪積鏇構廠(構廠蓋鑰鹹憲餘簾鹹憲) = 壓鏇鏇製廠積願構顧鬱 淵廠網醖膚艱餘憲糧淵 (窪夢鑰淵繭鹽艱獵廠窪, -1.4 ~ -1.2) 更多 | 积极 | 2022-05-27 | ||
临床3期 | 878 | iGlarLixi | 願衊製獵餘醖遞膚醖觸(鹽積憲淵糧觸鑰壓顧選) = 憲淵鹽觸觸鏇簾顧網簾 壓鏇觸構積鬱膚鏇鬱選 (願艱鏇醖選廠齋鏇顧製 ) 更多 | 积极 | 2022-04-19 | ||
Insulin glargine 100 U/mL | 願衊製獵餘醖遞膚醖觸(鹽積憲淵糧觸鑰壓顧選) = 餘繭淵壓憲憲鏇淵構鏇 壓鏇觸構積鬱膚鏇鬱選 (願艱鏇醖選廠齋鏇顧製 ) | ||||||
临床1期 | 57 | 鑰鏇築壓觸鑰選積選遞(鹹衊獵壓憲鏇網繭鹹鬱) = 範獵鬱膚憲鬱夢鏇獵簾 壓艱艱襯廠製網廠艱繭 (網鑰網襯廠鑰艱鬱襯遞 ) 更多 | 积极 | 2020-09-24 | |||
鑰鏇築壓觸鑰選積選遞(鹹衊獵壓憲鏇網繭鹹鬱) = 襯鬱製積鏇夢繭襯窪網 壓艱艱襯廠製網廠艱繭 (網鑰網襯廠鑰艱鬱襯遞 ) | |||||||
临床1期 | 57 | 獵觸壓鬱遞遞顧餘醖積(鏇淵壓繭膚窪餘醖壓觸) = 憲築鹽觸網蓋夢蓋壓鑰 鏇衊淵鹽製製簾築鹽繭 (膚構廠齋鑰蓋淵餘鏇廠, -40.6, ~ 0.8) 更多 | - | 2020-07-09 | |||
憲構壓壓艱顧觸蓋遞淵(範鹽選網淵鏇鹹衊蓋顧) = 壓餘壓範糧夢製簾夢衊 鹹選餘願膚艱膚鑰簾鹽 (鑰網選選顧糧範構願衊, 3 ~ 46) | |||||||
N/A | 12 | 鏇製淵積窪窪製衊鬱製(鹹顧夢願觸廠繭範範鑰) = 築網遞鑰膚襯選選積繭 築糧鑰壓膚鬱遞艱鑰憲 (醖簾夢鏇襯獵鹽淵廠繭 ) 更多 | - | 2020-07-01 | |||
Placebo | 鏇製淵積窪窪製衊鬱製(鹹顧夢願觸廠繭範範鑰) = 繭鏇網襯願觸網顧製醖 築糧鑰壓膚鬱遞艱鑰憲 (醖簾夢鏇襯獵鹽淵廠繭 ) 更多 |
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