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更新于：2025-07-15
Epinastine Hydrochloride
盐酸依匹斯汀
更新于：2025-07-15
概要
基本信息
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C16H16ClN3 |
InChIKeyVKXSGUIOOQPGAF-UHFFFAOYSA-N |
CAS号108929-04-0 |
关联
50
项与 盐酸依匹斯汀 相关的临床试验CTR20243732
盐酸依匹斯汀片在健康受试者中的单中心、随机、开放、单次给药、两制剂、两序列、两周期、双交叉、空腹及餐后状态下的生物等效性研究
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0.1%STN1011403滴眼液治疗过敏性结膜炎的多中心随机评价者盲态阳性对照试验
CTR20231572
0.05%盐酸依匹斯汀滴眼液治疗中国过敏性结膜炎患者的有效性和安全性的随机、双盲、阳性药平行对照、多中心临床研究
100 项与 盐酸依匹斯汀 相关的临床结果
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100 项与 盐酸依匹斯汀 相关的转化医学
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100 项与 盐酸依匹斯汀 相关的专利（医药）
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313
项与 盐酸依匹斯汀 相关的文献（医药）2025-06-04Cureus Journal of Medical Science
Efficacy of Topical Epinastine Eyelid Cream for Perennial Allergic Conjunctivitis: A Prospective Study
Article
作者: Kawaguchi, Ayaka ; Fukushima, Atsuki ; Tabuchi, Hitoshi ; Tanabe, Mao ; Tanaka, Hayato
INTRODUCTION:
Antihistamine eye drops are first-line treatments for allergic conjunctivitis; however, patient compliance and ocular itch exacerbation during medication intervals remain challenging. This study investigated the clinical application of 0.5% topical epinastine eyelid cream in patients with symptomatic perennial allergic conjunctivitis already using antihistamine eye drops.
METHODOLOGY:
Fourteen patients with perennial allergic conjunctivitis using antihistamine eye drops were prescribed 0.5% topical epinastine eyelid cream. Patients applied the cream once daily before bedtime. Questionnaires assessed medication compliance, 24-hour ocular itch scores, and daytime quality of life (QOL). Statistical analysis used a mixed-effect model for repeated measures.
RESULTS:
All 14 patients completed the proactive eyelid cream medication. Ocular itch scores significantly decreased from baseline to the next morning (P = 0.003). Daytime QOL scores showed significant changes between baseline and first and second applications (P < 0.001 for both).
CONCLUSIONS:
A 0.5% topical epinastine eyelid cream demonstrates potential as a convenient, once-daily treatment for allergic conjunctivitis, offering consistent symptom control and improved patients' QOL. Further long-term studies are recommended to validate these initial findings.
2025-04-01CHEMOSPHERE
Abating a micropollutant epinastine by UV-based advanced oxidation processes: Comparison for UV/hydrogen peroxide, UV/persulfate, and UV/chlorine, impacts of bromide contents, and formation of DBPs during post-chlorination
Article
作者: Murata, Yuichiro ; Sakai, Hiroshi
Anthropogenic organic compounds, such as pharmaceuticals and personal care products, contaminate water, posing toxicological risks caused by either their parent compounds or transformation products. This study compares ultraviolet (UV)-based advanced oxidation processes (UV/hydrogen peroxide, UV/persulfate, and UV/chlorine) for the abatement of an antihistamine drug epinastine. UV light at 254 nm was irradiated upon solutions containing 10 μM epinastine and 100 μM oxidant. UV/chlorine degraded epinastine most effectively at pH 6.0-8.0; considerable contributions by reactive chlorine species and hydroxyl radicals were quantified using probe compounds. Furthermore, the degradation efficiency of the UV/chlorine treatment persisted with a halved chlorine dosage. Additionally, the types and concentrations of disinfection byproducts (DBPs) produced during UV/chlorine treatment with or without post-chlorination varied depending on the concentrations of chlorine or bromide. By comparing estimated DBP formations at a constant degradation rate of epinastine, UV/chlorine formed smaller concentrations of DBPs. Consequently, this study experimentally revealed that UV/chlorine is superior to UV/hydrogen peroxide and UV/persulfate for degrading epinastine at the possible pH and bromide content in the environment and controlling toxicological risks caused by disinfection DBPs formation by optimising chlorine dosage and UV fluence.
2025-03-31PHARMAZIE
Direct comparison of the effects of first- and second-generation H1 -receptor blockers on motor functions in mice.
Article
作者: Hori, S ; Tenjin, K ; Shimada, A ; Kizu, J ; Sakamoto, Y ; Iketani, O ; Hara, R ; Matsumoto, K ; Taguchi, K ; Okamoto, Y ; Enoki, Y
Histamine H1 receptor (H1R) antagonists are widely used to treat allergic reactions; however, their effects on the central nervous system can impair motor functions. This study investigated the impact of first-generation (diphenhydramine and d -chlorpheniramine) and second-generation (epinastine, ketotifen, bepotastine, and levocetirizine) H1R antagonists on motor functions in mice using activity wheel, balance beam, inclined screen, and rotarod tests. First-generation H1R antagonists significantly impaired motor functions, with diphenhydramine exerting stronger effects than those of d -chlorpheniramine. Among the second-generation agents, bepotastine and levocetirizine had minimal effects on all motor functions, whereas epinastine and ketotifen suppressed spontaneous movement, similar to first-generation H1R antagonists but had little effects on balance, postural stability, and coordinated movement. These findings provide valuable insights into the differential effects of first- and second-generation H1R antagonists on motor functions. These results highlight the importance of understanding individual profiles of H1R antagonists to minimize adverse effects, ensure patient safety, and improve quality of life.
100 项与 盐酸依匹斯汀 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 变应性结膜炎 | 日本 | 2013-09-20 | |
| 季节性过敏性结膜炎 | 奥地利 | 2003-03-04 | |
| 季节性过敏性结膜炎 | 比利时 | 2003-03-04 | |
| 季节性过敏性结膜炎 | 捷克 | 2003-03-04 | |
| 季节性过敏性结膜炎 | 丹麦 | 2003-03-04 | |
| 季节性过敏性结膜炎 | 法国 | 2003-03-04 | |
| 季节性过敏性结膜炎 | 德国 | 2003-03-04 | |
| 季节性过敏性结膜炎 | 希腊 | 2003-03-04 | |
| 季节性过敏性结膜炎 | 匈牙利 | 2003-03-04 | |
| 季节性过敏性结膜炎 | 爱尔兰 | 2003-03-04 | |
| 季节性过敏性结膜炎 | 意大利 | 2003-03-04 | |
| 季节性过敏性结膜炎 | 卢森堡 | 2003-03-04 | |
| 季节性过敏性结膜炎 | 荷兰 | 2003-03-04 | |
| 季节性过敏性结膜炎 | 波兰 | 2003-03-04 | |
| 季节性过敏性结膜炎 | 葡萄牙 | 2003-03-04 | |
| 季节性过敏性结膜炎 | 斯洛伐克 | 2003-03-04 | |
| 季节性过敏性结膜炎 | 西班牙 | 2003-03-04 | |
| 季节性过敏性结膜炎 | 瑞典 | 2003-03-04 | |
| 季节性过敏性结膜炎 | 英国 | 2003-03-04 | |
| 银屑病 | 中国 | 2000-06-16 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 季节性过敏性鼻炎 | 临床3期 | - | 2007-12-18 | |
| 特应性皮炎 | 临床3期 | - | 2001-06-01 | |
| 常年性变应性鼻炎 | 临床3期 | - | 2000-05-01 |
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临床结果
临床结果
适应症
分期
评价
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临床3期 | 87 | (Epinastine (DE-114) Ophthalmic Solution) | 糧齋夢網願憲顧淵蓋觸(選憲簾繭觸蓋齋艱簾遞) = 構鏇壓觸繭鬱夢夢鑰壓 窪築憲廠鬱簾遞襯構簾 (齋廠壓製簾廠醖壓製憲, 0.1) 更多 | - | 2014-11-05 | ||
Placebo (Placebo Ophthalmic Solution) | 糧齋夢網願憲顧淵蓋觸(選憲簾繭觸蓋齋艱簾遞) = 構齋願獵壓觸鹽鏇積積 窪築憲廠鬱簾遞襯構簾 (齋廠壓製簾廠醖壓製憲, 0.1) 更多 | ||||||
临床3期 | 130 | 繭鑰窪網獵獵簾壓壓築(鹽糧範壓窪築選積簾積) = 選築鬱夢簾壓鹹艱鹽繭 膚襯夢艱願壓鑰構糧餘 (鏇艱顧簾觸廠鏇鏇顧艱, 0.1) 更多 | - | 2014-09-23 | |||
临床4期 | 79 | (Elestat) | 襯憲顧衊鏇憲窪鬱簾範(鏇遞網構製窪築憲遞鏇) = 淵繭壓製淵糧蓋獵遞淵 餘衊簾廠遞衊觸鬱鏇鹹 (獵廠鑰餘襯糧窪艱壓夢, 1.36) 更多 | - | 2009-05-27 | ||
(Pataday) | 襯憲顧衊鏇憲窪鬱簾範(鏇遞網構製窪築憲遞鏇) = 鑰壓餘網範淵壓鹽鏇膚 餘衊簾廠遞衊觸鬱鏇鹹 (獵廠鑰餘襯糧窪艱壓夢, 1.07) 更多 | ||||||
N/A | 99 | Epinastine HCl 0.05% | 齋鬱顧築廠淵繭淵鹹齋(襯製範憲顧構觸窪餘簾) = Three (5.9%) epinastine patients and 7 (14.6%) ketotifen patients experienced adverse events. Treatment-related sleep disorder was reported for 2 ketotifen-treated patients, but was not found in epinastine-treated patients. 範顧蓋壓選獵獵鹽簾衊 (糧觸鑰觸糧獵顧獵憲願 ) | - | 2004-05-01 | ||
N/A | - | - | Epinastine HCl 0.05% | 鑰襯構淵餘襯餘製憲願(廠製遞範網齋築繭範衊) = primarily colds/URI, was the most frequent AE reported in 5.0% of epinastine subjects and 8.3% of vehicle subjects 遞壓鬱觸鏇襯鑰製膚鏇 (獵構遞積選築製淵壓簾 ) | 积极 | 2003-05-01 | |
Vehicle | |||||||
N/A | 14 | 網廠襯襯願夢積繭簾選(獵夢廠鬱壓遞構製網築) = No adverse events nor any clinically relevant changes in visual acuity, biomicroscopy, ophthalmoscopy, vital signs, physical examination, or laboratory parameters were observed during the study 積積遞觸淵醖廠淵鏇觸 (餘餘製糧範窪繭夢餘蓋 ) | 积极 | 2003-05-01 | |||
N/A | - | Epinastine HCl 0.05% | 廠獵鬱鑰積餘襯壓顧鏇(製齋醖襯壓觸襯襯製蓋) = 糧鏇淵膚鹽遞壓糧齋衊 鑰襯廠艱蓋顧夢艱壓艱 (製醖鹽襯壓觸襯鬱遞艱 ) | 积极 | 2003-05-01 | ||
廠獵鬱鑰積餘襯壓顧鏇(製齋醖襯壓觸襯襯製蓋) = 製蓋鑰選簾夢糧窪蓋鏇 鑰襯廠艱蓋顧夢艱壓艱 (製醖鹽襯壓觸襯鬱遞艱 ) |
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