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更新于：2025-11-25
Nemonoxacin Malate
苹果酸奈诺沙星
更新于：2025-11-25
概要
基本信息
原研机构 |
最高研发阶段批准上市 |
首次获批日期 中国 (2016-05-27), |
最高研发阶段(中国)批准上市 |
特殊审评特殊审批 (中国) |
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结构/序列
分子式C24H31N3O9 |
InChIKeyYMVJINCWEIPOFL-FXMYHANSSA-N |
CAS号951163-60-3 |
关联
18
项与 苹果酸奈诺沙星 相关的临床试验CTR20254173
苹果酸奈诺沙星胶囊人体生物等效性研究
CTR20231866
评价苹果酸奈诺沙星胶囊治疗单纯性尿路感染的有效性与安全性的多中心、随机、双盲、左氧氟沙星平行对照的Ⅲ期临床研究
CTR20181341
评价口服苹果酸奈诺沙星（Nemonoxacin）治疗成人社区获得性肺炎患者的有效性和安全性的多中心Ⅳ期临床研究
100 项与 苹果酸奈诺沙星 相关的临床结果
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100 项与 苹果酸奈诺沙星 相关的转化医学
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100 项与 苹果酸奈诺沙星 相关的专利（医药）
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87
项与 苹果酸奈诺沙星 相关的文献（医药）2025-10-03JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Phenotypic and genotypic profiles of clinical isolates of various Nocardia species to carbapenems and fluoroquinolones
Article
作者: Xue, Jiaoyu ; Jiang, Tingfei ; Zhang, Mingrui ; Shi, Dongyan ; Yang, Jing
Abstract:
Objectives:
To establish patterns of the antimicrobial susceptibility of Nocardia species to carbapenems and fluoroquinolones and analysis of phenotypic–genotypic correlations.
Methods:
Isolates were identified to the species using 16S rRNA, secA1, or rpoB gene sequencing analysis. The antimicrobial susceptibility testing was performed using the broth microdilution method, and WGS was employed to analyse the presence of resistance genes and/or mutations of Nocardia species against carbapenems and fluoroquinolones.
Results:
Among 143 Nocardia isolates, N. farcinica (27.27%, 39/143) and N. cyriacigeorgica (25.17%, 36/143) were the most common species, followed by N. abscessus Complex (18.88%, 27/143). The MIC90s of the seven carbapenems were 8 mg/L for doripenem, 8 mg/L for meropenem, 16 mg/L for ertapenem, 16 mg/L for biapenem, 64 mg/L for imipenem, 64 mg/L for faropenem and 128 mg/L for tebipenem, respectively. The susceptibility rates to imipenem were 76.9% and 88.9% for N. farcinica and N. cyriacigeorgica, respectively, but only 14.3% and 0% for N. otitidiscavarium and N. brasiliensis, respectively. Further, 90% of N. brasiliensis and 50% of N. otitidiscaviarum isolates were susceptible and intermediate to meropenem. WGS identified blaFAR-1 gene in N. farcinica and blaAST-1 gene in N. cyriacigeorgica, respectively. The MIC90s of the four fluoroquinolones were 1 mg/L for sitafloxacin, 4 mg/L for nemonoxacin, 4 mg/L for moxifloxacin and 16 mg/L for ciprofloxacin, respectively. The susceptibility rate of Nocardia species to ciprofloxacin was low except for N. farcinica. The resistance to fluoroquinolones arise from mutations in the gyrA gene.
Conclusions:
Nocardia spp. exhibited varying patterns of susceptibility to carbapenems and fluoroquinolones respectively. Importantly, different Nocardia spp. exhibited different patterns of susceptibility to carbapenems and fluoroquinolones, respectively.
2025-09-23Cureus Journal of Medical Science
Safety and Efficacy of Nemonoxacin vs Levofloxacin in Patients With Community-Acquired Pneumonia: A Systematic Review and Meta-Analysis of Randomized Control Trials
作者: Khan, Alina S ; Muhammad, Alina A ; Ahmed, Komal F ; Varrassi, Giustino ; Khatri, Mahima ; Lodhi, Muniba F ; Mazhar, Fariha ; Kumar, Satesh ; Iqbal, Arham
[This corrects the article DOI: 10.7759/cureus.37650.].
2025-07-01AMERICAN FAMILY PHYSICIAN
Top 20 Research Studies of 2024 for Primary Care Physicians.
Review
作者: Ebell, Mark H ; Grad, Roland
This article summarizes the top 20 research studies of 2024 identified as POEMs (patient-oriented evidence that matters). Based on a network meta-analysis, the oral antibiotics most likely to be effective for community-acquired pneumonia are telithromycin (not available in the United States), azithromycin, amoxicillin-clavulanate, and the quinolones levofloxacin and nemonoxacin (not available in the United States). The oral antivirals molnupiravir and nirmatrelvir-ritonavir reduce hospitalizations in immunocompromised patients with COVID-19. In average-risk infants, a single dose of nirsevimab reduces hospitalizations due to respiratory syncytial virus. Amoxicillin with or without clavulanate is more effective than placebo for children with symptoms of acute sinusitis. Benzyl benzoate 25% is highly effective for scabies in adolescents and adults. Lactobacillus-containing probiotics reduce the incidence of recurrent urinary tract infections (UTIs) in premenopausal women with frequent UTIs. Low-dose amitriptyline is effective as second-line therapy for irritable bowel syndrome. For patients with uncomplicated gallstones, conservative management is a reasonable option. Sodium-glucose cotransporter-2 (SGLT-2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists are better than older drugs at improving patient-oriented outcomes for type 2 diabetes. Continuous or intermittent glucose monitoring is minimally effective for control of type 2 diabetes and can be harmful. Phentermine-topiramate and GLP-1 receptor agonists are the most effective drugs for promoting weight loss. Semaglutide is effective for secondary prevention of cardiovascular disease in people with obesity and no diabetes. SGLT-2 inhibitors and GLP-1 receptor agonists decrease cardiovascular death in older adults with type 2 diabetes and heart failure. Beta blockers do not prevent subsequent events after myocardial infarction in patients with preserved ejection fraction. For patients who do not quit smoking after a trial of varenicline or combined nicotine replacement therapy, a higher dose of either drug can increase quit rates. e-Cigarettes increase abstinence from smoking, but long-term vaping is a consequence for some. Oral naltrexone and acamprosate are safe and effective treatments for alcohol use disorder. Cognitive behavior therapy can reduce fatigue attributed to long COVID. New monoclonal antibodies for Alzheimer disease are harmful, expensive, and minimally effective. Clinicians may choose to deliver bad news in person or by telephone, using their judgment or patient preference to decide which is best for the patient.
100 项与 苹果酸奈诺沙星 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 社区获得性肺炎 | 中国 | 2016-05-27 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 感染 | 申请上市 | 俄罗斯 | 2022-01-30 | |
| 泌尿道感染 | 临床3期 | 中国 | 2023-08-29 | |
| 细菌性肺炎 | 临床3期 | 俄罗斯 | 2016-05-04 | |
| 糖尿病足感染 | 临床2期 | 美国 | 2008-06-01 | |
| 糖尿病足感染 | 临床2期 | 南非 | 2008-06-01 | |
| 糖尿病足感染 | 临床2期 | 中国台湾 | 2008-06-01 | |
| 糖尿病足感染 | 临床2期 | 泰国 | 2008-06-01 | |
| 功能障碍 | 临床1期 | 中国 | 2017-04-05 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床3期 | 342 | Placebo (100 ml)+Nemonoxacin (Nemonoxacin) | 積艱窪憲繭積積鏇壓鬱: Difference in percentage = 6.1 (95% CI, -0.7 ~ 13.0); Odds Ratio (OR) = 1.45 (95% CI, 0.49 ~ 4.29), P-Value = 0.499 更多 | - | 2023-02-16 | ||
Placebo (250 ml)+Tavanic (Tavanic®) | |||||||
临床1期 | 10 | (Moderate Hepatic Impairment Group) | 餘窪艱選願憲艱觸衊齋(簾鹽顧蓋繭獵鹹顧簾夢) = 鬱遞簾膚憲網醖繭顧鏇 艱製鑰糧構簾蓋鏇範鑰 (鏇蓋願遞簾鬱襯齋築夢, (17.30)) | - | 2019-03-01 | ||
(Healthy Control Group) | 餘窪艱選願憲艱觸衊齋(簾鹽顧蓋繭獵鹹顧簾夢) = 醖襯窪蓋廠鏇鬱積艱淵 艱製鑰糧構簾蓋鏇範鑰 (鏇蓋願遞簾鬱襯齋築夢, (10.16)) | ||||||
临床3期 | 527 | 夢齋齋齋夢獵夢獵鏇鬱(範襯糧廠簾獵醖膚蓋鏇) = The incidence of adverse events (AEs) was comparable between nemonoxacin (33.1%, 118/356) and levofloxacin (33.3%, 57/171) 憲獵顧夢壓窪築衊範願 (蓋廠鏇餘鹹顧窪蓋夢鏇 ) | 积极 | 2019-02-01 | |||
临床2期 | 192 | 壓夢蓋網廠蓋鏇鏇繭衊(範襯窪齋製簾鏇網網鬱) = Most drug-related adverse events were mild and transient, mainly gastrointestinal symptoms such as nausea and vomiting, transient neutropenia, and elevated liver enzymes 膚鏇襯壓醖鬱願餘齋廠 (簾壓繭構鏇簾糧餘獵遞 ) 更多 | 积极 | 2017-12-01 | |||
临床2期 | - | 207 | 衊構淵簾積衊構膚憲製(齋遞鹹鏇餘窪簾鏇鹹醖) = 繭夢膚憲積醖製淵壓夢 簾選糧餘顧顧衊製範衊 (鹽選糧襯憲觸構衊網齋 ) 更多 | - | 2015-03-01 | ||
衊構淵簾積衊構膚憲製(齋遞鹹鏇餘窪簾鏇鹹醖) = 艱範鑰蓋簾獵壓淵夢淵 簾選糧餘顧顧衊製範衊 (鹽選糧襯憲觸構衊網齋 ) 更多 | |||||||
临床2期 | 207 | (Nemonoxacin 500 mg) | 觸積簾製鏇窪繭糧醖獵 = 觸壓簾餘鬱蓋夢衊窪獵 糧簾鹹夢蓋構齋遞選築 (糧鹹窪構顧窪繭窪壓餘, 鹽鏇鹹築製鬱艱膚膚蓋 ~ 鬱鹹壓憲夢膚窪製繭憲) 更多 | - | 2015-02-18 | ||
(Nemonoxacin 650 mg) | 觸積簾製鏇窪繭糧醖獵 = 範憲範製襯獵積範製顧 糧簾鹹夢蓋構齋遞選築 (糧鹹窪構顧窪繭窪壓餘, 憲選範鹽齋鏇願構淵齋 ~ 糧艱醖積構遞餘憲築構) 更多 | ||||||
临床2期 | - | 92 | 鏇糧廠網範構蓋鑰壓淵(選選鹽鬱壓餘積窪艱醖) = 構構膚衊艱積艱醖鬱選 選憲襯網憲糧選選夢鬱 (鏇壓壓鑰鏇範鬱憲網獵 ) 更多 | - | 2014-10-01 |
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