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更新于：2026-04-22
Nemonoxacin Malate
苹果酸奈诺沙星
更新于：2026-04-22
概要
基本信息
原研机构 |
最高研发阶段批准上市 |
首次获批日期 中国 (2016-05-27), |
最高研发阶段(中国)批准上市 |
特殊审评特殊审批 (中国) |
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结构/序列
分子式C24H31N3O9 |
InChIKeyYMVJINCWEIPOFL-FXMYHANSSA-N |
CAS号951163-60-3 |
关联
18
项与 苹果酸奈诺沙星 相关的临床试验CTR20254173
苹果酸奈诺沙星胶囊人体生物等效性研究
CTR20231866
评价苹果酸奈诺沙星胶囊治疗单纯性尿路感染的有效性与安全性的多中心、随机、双盲、左氧氟沙星平行对照的Ⅲ期临床研究
CTR20181341
评价口服苹果酸奈诺沙星（Nemonoxacin）治疗成人社区获得性肺炎患者的有效性和安全性的多中心Ⅳ期临床研究
100 项与 苹果酸奈诺沙星 相关的临床结果
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100 项与 苹果酸奈诺沙星 相关的转化医学
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100 项与 苹果酸奈诺沙星 相关的专利（医药）
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86
项与 苹果酸奈诺沙星 相关的文献（医药）2025-10-03JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Phenotypic and genotypic profiles of clinical isolates of various Nocardia species to carbapenems and fluoroquinolones
Article
作者: Xue, Jiaoyu ; Jiang, Tingfei ; Zhang, Mingrui ; Shi, Dongyan ; Yang, Jing
Abstract:
Objectives:
To establish patterns of the antimicrobial susceptibility of Nocardia species to carbapenems and fluoroquinolones and analysis of phenotypic–genotypic correlations.
Methods:
Isolates were identified to the species using 16S rRNA, secA1, or rpoB gene sequencing analysis. The antimicrobial susceptibility testing was performed using the broth microdilution method, and WGS was employed to analyse the presence of resistance genes and/or mutations of Nocardia species against carbapenems and fluoroquinolones.
Results:
Among 143 Nocardia isolates, N. farcinica (27.27%, 39/143) and N. cyriacigeorgica (25.17%, 36/143) were the most common species, followed by N. abscessus Complex (18.88%, 27/143). The MIC90s of the seven carbapenems were 8 mg/L for doripenem, 8 mg/L for meropenem, 16 mg/L for ertapenem, 16 mg/L for biapenem, 64 mg/L for imipenem, 64 mg/L for faropenem and 128 mg/L for tebipenem, respectively. The susceptibility rates to imipenem were 76.9% and 88.9% for N. farcinica and N. cyriacigeorgica, respectively, but only 14.3% and 0% for N. otitidiscavarium and N. brasiliensis, respectively. Further, 90% of N. brasiliensis and 50% of N. otitidiscaviarum isolates were susceptible and intermediate to meropenem. WGS identified blaFAR-1 gene in N. farcinica and blaAST-1 gene in N. cyriacigeorgica, respectively. The MIC90s of the four fluoroquinolones were 1 mg/L for sitafloxacin, 4 mg/L for nemonoxacin, 4 mg/L for moxifloxacin and 16 mg/L for ciprofloxacin, respectively. The susceptibility rate of Nocardia species to ciprofloxacin was low except for N. farcinica. The resistance to fluoroquinolones arise from mutations in the gyrA gene.
Conclusions:
Nocardia spp. exhibited varying patterns of susceptibility to carbapenems and fluoroquinolones respectively. Importantly, different Nocardia spp. exhibited different patterns of susceptibility to carbapenems and fluoroquinolones, respectively.
2025-09-23Cureus Journal of Medical Science
Safety and Efficacy of Nemonoxacin vs Levofloxacin in Patients With Community-Acquired Pneumonia: A Systematic Review and Meta-Analysis of Randomized Control Trials
作者: Khan, Alina S ; Muhammad, Alina A ; Ahmed, Komal F ; Varrassi, Giustino ; Khatri, Mahima ; Lodhi, Muniba F ; Mazhar, Fariha ; Kumar, Satesh ; Iqbal, Arham
[This corrects the article DOI: 10.7759/cureus.37650.].
2025-07-01AMERICAN FAMILY PHYSICIAN
Top 20 Research Studies of 2024 for Primary Care Physicians.
Review
作者: Ebell, Mark H ; Grad, Roland
This article summarizes the top 20 research studies of 2024 identified as POEMs (patient-oriented evidence that matters). Based on a network meta-analysis, the oral antibiotics most likely to be effective for community-acquired pneumonia are telithromycin (not available in the United States), azithromycin, amoxicillin-clavulanate, and the quinolones levofloxacin and nemonoxacin (not available in the United States). The oral antivirals molnupiravir and nirmatrelvir-ritonavir reduce hospitalizations in immunocompromised patients with COVID-19. In average-risk infants, a single dose of nirsevimab reduces hospitalizations due to respiratory syncytial virus. Amoxicillin with or without clavulanate is more effective than placebo for children with symptoms of acute sinusitis. Benzyl benzoate 25% is highly effective for scabies in adolescents and adults. Lactobacillus-containing probiotics reduce the incidence of recurrent urinary tract infections (UTIs) in premenopausal women with frequent UTIs. Low-dose amitriptyline is effective as second-line therapy for irritable bowel syndrome. For patients with uncomplicated gallstones, conservative management is a reasonable option. Sodium-glucose cotransporter-2 (SGLT-2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists are better than older drugs at improving patient-oriented outcomes for type 2 diabetes. Continuous or intermittent glucose monitoring is minimally effective for control of type 2 diabetes and can be harmful. Phentermine-topiramate and GLP-1 receptor agonists are the most effective drugs for promoting weight loss. Semaglutide is effective for secondary prevention of cardiovascular disease in people with obesity and no diabetes. SGLT-2 inhibitors and GLP-1 receptor agonists decrease cardiovascular death in older adults with type 2 diabetes and heart failure. Beta blockers do not prevent subsequent events after myocardial infarction in patients with preserved ejection fraction. For patients who do not quit smoking after a trial of varenicline or combined nicotine replacement therapy, a higher dose of either drug can increase quit rates. e-Cigarettes increase abstinence from smoking, but long-term vaping is a consequence for some. Oral naltrexone and acamprosate are safe and effective treatments for alcohol use disorder. Cognitive behavior therapy can reduce fatigue attributed to long COVID. New monoclonal antibodies for Alzheimer disease are harmful, expensive, and minimally effective. Clinicians may choose to deliver bad news in person or by telephone, using their judgment or patient preference to decide which is best for the patient.
100 项与 苹果酸奈诺沙星 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 社区获得性肺炎 | 中国 | 2016-05-27 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 感染 | 申请上市 | 俄罗斯 | 2022-01-30 | |
| 泌尿道感染 | 临床3期 | 中国 | 2023-08-29 | |
| 细菌性肺炎 | 临床3期 | 俄罗斯 | 2016-05-04 | |
| 糖尿病足感染 | 临床2期 | 美国 | 2008-06-01 | |
| 糖尿病足感染 | 临床2期 | 南非 | 2008-06-01 | |
| 糖尿病足感染 | 临床2期 | 中国台湾 | 2008-06-01 | |
| 糖尿病足感染 | 临床2期 | 泰国 | 2008-06-01 | |
| 功能障碍 | 临床1期 | 中国 | 2017-04-05 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床3期 | 342 | Placebo (100 ml)+Nemonoxacin (Nemonoxacin) | 淵範壓顧鏇壓廠選壓襯: Difference in percentage = 6.1 (95% CI, -0.7 ~ 13.0); Odds Ratio (OR) = 1.45 (95% CI, 0.49 ~ 4.29), P-Value = 0.499 更多 | - | 2023-02-16 | ||
Placebo (250 ml)+Tavanic (Tavanic®) | |||||||
临床1期 | 10 | (Moderate Hepatic Impairment Group) | 鹽鹹壓製壓積獵網鬱鑰(願顧襯範範鹽憲選鬱衊) = 壓鹹鬱糧蓋鏇憲夢醖築 膚艱鑰製鬱繭鏇鬱廠糧 (鹽醖鹹糧範鏇積顧齋窪, (17.30)) | - | 2019-03-01 | ||
(Healthy Control Group) | 鹽鹹壓製壓積獵網鬱鑰(願顧襯範範鹽憲選鬱衊) = 鹹願鹽鬱憲遞願憲積觸 膚艱鑰製鬱繭鏇鬱廠糧 (鹽醖鹹糧範鏇積顧齋窪, (10.16)) | ||||||
临床3期 | 527 | 憲鏇鹹獵獵醖醖餘廠選(鬱壓醖鬱製糧遞壓襯壓) = The incidence of adverse events (AEs) was comparable between nemonoxacin (33.1%, 118/356) and levofloxacin (33.3%, 57/171) 繭積糧顧窪築鏇淵選選 (鹽壓膚製願製糧遞糧衊 ) | 积极 | 2019-02-01 | |||
临床2期 | 192 | 憲夢網齋鹽鑰廠獵襯構(窪願淵觸艱鏇窪夢構醖) = Most drug-related adverse events were mild and transient, mainly gastrointestinal symptoms such as nausea and vomiting, transient neutropenia, and elevated liver enzymes 範構鑰築繭繭夢艱餘願 (積鏇鹽淵網糧鹹廠鏇壓 ) 更多 | 积极 | 2017-12-01 | |||
临床2期 | - | 207 | 構鏇鏇鹽膚積衊鑰鹹繭(蓋夢顧襯憲製築鏇鹹積) = 醖構鑰廠構廠構積艱構 鹽衊艱積鑰艱獵繭夢醖 (簾遞鑰廠遞鏇鹹鏇構鏇 ) 更多 | - | 2015-03-01 | ||
構鏇鏇鹽膚積衊鑰鹹繭(蓋夢顧襯憲製築鏇鹹積) = 鬱淵齋繭夢製憲鏇膚構 鹽衊艱積鑰艱獵繭夢醖 (簾遞鑰廠遞鏇鹹鏇構鏇 ) 更多 | |||||||
临床2期 | 207 | (Nemonoxacin 500 mg) | 憲鬱蓋齋鹽蓋糧網淵膚 = 膚醖窪衊艱襯構遞餘遞 廠獵簾積鑰繭簾築獵餘 (醖鹽鑰齋廠鑰齋憲廠鏇, 製願鹹鏇糧憲繭遞鑰築 ~ 衊鹽鏇衊鑰窪憲壓積壓) 更多 | - | 2015-02-18 | ||
(Nemonoxacin 650 mg) | 憲鬱蓋齋鹽蓋糧網淵膚 = 蓋餘繭構衊鏇網繭構艱 廠獵簾積鑰繭簾築獵餘 (醖鹽鑰齋廠鑰齋憲廠鏇, 顧蓋簾選願簾夢遞獵憲 ~ 獵襯艱壓糧糧鬱網觸衊) 更多 | ||||||
临床2期 | - | 92 | 鹽壓遞遞築醖膚鹹廠衊(積鏇鑰範壓簾膚窪鑰壓) = 繭願構鬱選獵窪衊鏇願 鬱醖夢鏇鏇醖顧襯築蓋 (衊願獵膚蓋選憲鑰範壓 ) 更多 | - | 2014-10-01 |
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