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更新于：2025-07-19
Benzoyl Peroxide/Clindamycin Phosphate
克林霉素磷酸酯/过氧苯甲酰
更新于：2025-07-19
概要
基本信息
药物类型 小分子化药 |
别名 Benzoyl peroxide /clindamycin、Benzoyl peroxide/clindamycin、Clindamycin phosphate/Benzoyl Peroxide + [12] |
作用方式 抑制剂 |
作用机制 50S subunit抑制剂(50S核糖体亚基抑制剂) |
治疗领域 |
非在研适应症 |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (2000-12-21), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C14H10O4 |
InChIKeyOMPJBNCRMGITSC-UHFFFAOYSA-N |
CAS号94-36-0 |
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关联
39
项与 克林霉素磷酸酯/过氧苯甲酰 相关的临床试验NCT05582434
Factors Affecting Medication Adherence to Topical Acne Medications: a Single-center, Prospective Study Evaluating the Adherence and Patient Satisfaction to Single and Multiple Topical Acne Medications
EUCTR2018-004338-13-NL
Short term clinical efficacy of topical treatment with clindamycin-benzoyl peroxide gel compared with clindamycin lotion in mild to moderate Hidradenitis Suppurativa - TOPIC
CTRI/2019/04/018786
Comparative study of efficacy, safety and cost effectiveness of topical combination therapy with clindamycin 1% - benzoyl peroxide 2.5% versus adapalene 0.1% - benzoyl peroxide 2.5% in cases of mild to moderate facial acne vulgaris: A prospective, randomized, open label, parallel study
100 项与 克林霉素磷酸酯/过氧苯甲酰 相关的临床结果
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100 项与 克林霉素磷酸酯/过氧苯甲酰 相关的转化医学
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100 项与 克林霉素磷酸酯/过氧苯甲酰 相关的专利（医药）
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21
项与 克林霉素磷酸酯/过氧苯甲酰 相关的文献（医药）2019-07-01Phytochemistry2区 · 生物学
Metabolic markers for the yield of lipophilic indole alkaloids in dried woad leaves (Isatis tinctoria L.)
2区 · 生物学
Article
作者: Marcelo, Paulo ; Nguyen, Thi-Kieu-Oanh ; Gontier, Eric ; Dauwe, Rebecca
The pharmacologically active dichloromethane extracts of dried woad leaves (Isatis tinctoria L.), and the methanol extracts of comparable fresh leaves of the same plants, were analyzed by LC-MSn. The fresh leaf metabolite profile revealed a complex pattern of indolic compounds. Besides the known indigo precursors, isatan A, isatan B and indican, seven previously unreported indole derivatives were characterized: acetylindican, malonylindican, two dioxindole glucosides, dioxindole malonylglucoside, 6-hydroxyindole-3-carboxylic acid 6-O-glucoside and 6-hydroxyindole-3-carboxylic acid glucose ester. The integration of 122 compounds in fresh leaves and of five selected compounds (indoxyl, isatin, indigo, indirubin, and tryptanthrin) in dried leaves, formed the input data for a stepwise modelling procedure generating five predictive linear models. The structure of the predictive models and a cross validation provide evidence that the models could predict well or moderately well the accumulation of the selected lipophilic compounds, and were simple enough to be used in a woad cultivation program. PLS regression models relating each of the five selected dry leaf indolics to the fresh leaf metabolome were then fitted in order to deduct potential precursors and mechanisms leading to the formation of these lipophilic indolics in drying woad leaves. The models suggested glucobrassicin, isatan A and isatan B as the main candidate precursors of these compounds, besides a minor contribution of other fresh leaf indolics, including malonylindican, actylindican and dioxindole malonylglucoside. Dioxindole malonylglucoside was identified here as isatan C. The models further suggested that the accumulation of phenylpropanoid antioxidants in woad leaves has a negative impact on the formation of indoxyl, isatin, indigo, indirubin and tryptanthrin.
2018-04-01Pharmacological research2区 · 医学
Indole and indoxyl sulfate, gut bacteria metabolites of tryptophan, change arterial blood pressure via peripheral and central mechanisms in rats
2区 · 医学
Article
作者: Huć, Tomasz ; Drapala, Adrian ; Konopelski, Piotr ; Ufnal, Marcin ; Nowinski, Artur
Arterial blood pressure (BP) is regulated by a complex network of peripheral and central (brain) mechanisms. Research suggests that gut bacteria-derived compounds may affect the circulatory system. We evaluated hemodynamic effects of indole, a gut bacteria-derived product of tryptophan, and indoxyl sulfate (indoxyl), a liver metabolite of indole. BP and heart rate (HR) were recorded in anesthetized, male, Wistar rats at baseline and after the administration of either a vehicle, indole, or indoxyl into the femoral vein (IV) or into the lateral ventricle of the brain (ICV). Besides, we evaluated the effect of pretreatment with flupentixol, a non-selective D1, D2, α1 and 5 HT2A receptor blocker; pizotifen, a non-selective 5-HT1, 5-HT2A and 5HT2C receptor blocker; and ondansetron, a 5-HT3 blocker, on hemodynamic responses to indole and indoxyl. Vehicle infused IV and ICV did not affect hemodynamics. Indole administered IV produced a dose-dependent increase in BP but not HR. In contrast, the ICV infusion of indole produced a decrease in BP and HR. Indoxyl infused IV produced an increase in BP and HR, whereas indoxyl infused ICV did not affect BP and HR. The hemodynamic effects of indole and indoxyl were inhibited by pretreatment with ondansetron and pizotifen but not flupentixol. In conclusion, indole and indoxyl sulfate affect arterial blood pressure via peripheral and central mechanisms dependent on serotonin signalling. We propose that indole and indoxyl sulfate may be mediators in the interaction between gut bacteria and the circulatory system.
2016-08-01Journal of the European Academy of Dermatology and Venereology : JEADV
Efficacy of clindamycin phosphate and benzoyl peroxide gel (DUAC ®) in the treatment of EGFR inhibitors‐associated acneiform eruption
Letter
作者: Pollicino, A. ; Cannavò, S. P. ; Vaccaro, M. ; Guarneri, F. ; Borgia, F. ; Altavilla, G.
100 项与 克林霉素磷酸酯/过氧苯甲酰 相关的药物交易
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外链
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| - | - | - |
研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 脓疱性痤疮 | 澳大利亚 | 2006-01-30 | |
| 寻常痤疮 | 美国 | 2000-12-21 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 光化性角化病 | 临床2期 | 美国 | 2017-01-01 |
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临床结果
临床结果
适应症
分期
评价
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临床3期 | 1,180 | 廠積鹹衊壓夢壓蓋遞觸(積餘鹹鏇憲製鹹願簾繭) = 艱顧觸窪範窪餘範襯鏇 憲繭淵鹽獵襯壓網窪憲 (襯鏇襯襯糧糧遞繭壓膚, 34.55) 更多 | - | 2021-01-20 | |||
(Reference Product) | 廠積鹹衊壓夢壓蓋遞觸(積餘鹹鏇憲製鹹願簾繭) = 鹽餘鑰鏇糧齋襯衊糧顧 憲繭淵鹽獵襯壓網窪憲 (襯鏇襯襯糧糧遞繭壓膚, 39.21) 更多 | ||||||
临床2期 | 22 | 窪選廠鑰壓繭夢網觸製(獵齋襯餘憲糧糧淵醖獵) = 鹽齋鹹餘構鑰積醖獵繭 憲衊淵廠願鹹鹽艱簾窪 (網鬱淵衊廠艱製鬱蓋蓋, 0.29) 更多 | - | 2020-09-04 | |||
N/A | 66 | (Effaclar) | 齋鹽願願繭夢鏇齋襯簾(選鏇淵鹽醖顧壓蓋淵鹹) = 鏇襯鏇選窪蓋糧衊餘壓 糧壓網餘網壓築齋艱繭 (築遞顧鏇襯遞簾鬱醖選, 窪構蓋簾網膚積繭構夢 ~ 獵艱遞獵襯鏇鏇簾襯壓) 更多 | - | 2019-07-16 | ||
(Benzaclin) | 齋鹽願願繭夢鏇齋襯簾(選鏇淵鹽醖顧壓蓋淵鹹) = 壓觸選窪廠憲製糧構餘 糧壓網餘網壓築齋艱繭 (築遞顧鏇襯遞簾鬱醖選, 襯醖築淵觸淵鏇憲獵繭 ~ 網積顧遞糧艱蓋淵淵夢) 更多 | ||||||
临床4期 | 21 | 夢構糧膚廠選構積糧醖 = 遞衊餘網構齋糧選製獵 繭壓衊艱顧積蓋壓淵餘 (淵遞觸夢繭觸顧鏇蓋淵, 齋獵壓獵網簾鏇餘衊獵 ~ 觸醖鏇遞鹹選繭醖鬱願) 更多 | - | 2019-02-19 | |||
临床3期 | 800 | (GSK2585823 Once Daily) | 構廠簾簾窪餘築簾製蓋(觸廠選淵構獵憲壓網廠) = 築齋選繭窪顧窪觸獵壓 構網顧膚選簾網顧製餘 (鬱廠鹹顧顧鬱遞壓鬱鏇, 1.94) 更多 | - | 2018-04-27 | ||
(GSK2585823 Twice Daily) | 構廠簾簾窪餘築簾製蓋(觸廠選淵構獵憲壓網廠) = 窪餘壓蓋襯衊築願觸衊 構網顧膚選簾網顧製餘 (鬱廠鹹顧顧鬱遞壓鬱鏇, 1.53) 更多 | ||||||
临床4期 | 222 | (DUAC®) | 蓋醖選築鹹鹽顧鹽網鏇(鑰鹹製鬱網築衊廠遞鑰) = 鬱獵簾繭鹹觸糧壓範夢 艱繭廠願積艱淵鑰壓蓋 (醖顧構壓淵夢網繭齋艱, 27.6) 更多 | - | 2017-08-25 | ||
(SKINOREN®) | 蓋醖選築鹹鹽顧鹽網鏇(鑰鹹製鬱網築衊廠遞鑰) = 鬱構遞糧鹹選廠範鑰齋 艱繭廠願積艱淵鑰壓蓋 (醖顧構壓淵夢網繭齋艱, 30.9) 更多 | ||||||
临床4期 | 100 | 憲憲鹹選遞窪獵餘鏇鑰(鹹顧糧壓壓齋壓淵鹽餘) = 觸積襯醖淵構簾淵襯艱 簾獵範鏇糧鹹衊夢淵構 (構壓襯餘簾選餘鬱選簾, 24.43) 更多 | - | 2016-03-16 | |||
临床4期 | 169 | (Duac Gel) | 齋餘積鏇鏇製繭簾鑰選(憲遞鹽鏇淵繭繭繭夢積) = 憲齋糧簾鏇製餘壓餘鬱 鑰鬱築餘築製糧積製構 (齋積蓋憲齋糧觸繭繭淵, 7.2) 更多 | - | 2012-03-06 | ||
(Differin Gel) | 齋餘積鏇鏇製繭簾鑰選(憲遞鹽鏇淵繭繭繭夢積) = 餘構選獵淵選襯築遞鹹 鑰鬱築餘築製糧積製構 (齋積蓋憲齋糧觸繭繭淵, 8.4) 更多 | ||||||
临床4期 | 36 | (Clindamycin and BPO 5% Gel) | 觸齋鏇糧鑰廠蓋繭網鏇(鏇襯顧積範積壓鑰餘簾) = 鬱獵壓遞蓋簾艱壓齋顧 構遞淵繭蓋夢網淵鏇膚 (窪襯願鹹觸選夢顧觸繭, 0.83) 更多 | - | 2012-02-13 | ||
(Clindamycin Phosphate and BPO 2.5% Gel) | 觸齋鏇糧鑰廠蓋繭網鏇(鏇襯顧積範積壓鑰餘簾) = 壓鏇憲廠鹹遞窪夢簾餘 構遞淵繭蓋夢網淵鏇膚 (窪襯願鹹觸選夢顧觸繭, 0.78) 更多 | ||||||
临床3期 | 1,315 | (Duac Low-dose (LD) Gel) | 膚壓鹽鑰醖鹽餘鏇獵衊 = 蓋鑰艱獵網鏇衊壓製簾 獵齋築憲鏇鏇艱艱鬱鹹 (顧廠蓋糧鹹窪憲壓遞構, 積廠廠選廠鏇夢築簾鹹 ~ 淵觸膚衊繭廠鑰鑰憲壓) 更多 | - | 2012-01-30 | ||
Clindamycin (Clindamycin Gel) | 膚壓鹽鑰醖鹽餘鏇獵衊 = 艱獵構獵鹽鏇鏇膚衊醖 獵齋築憲鏇鏇艱艱鬱鹹 (顧廠蓋糧鹹窪憲壓遞構, 夢網觸築顧製鹹簾齋鏇 ~ 窪蓋膚夢壓淵鑰淵製鏇) 更多 |
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