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更新于：2025-06-30
Benzoyl Peroxide/Clindamycin Phosphate
克林霉素磷酸酯/过氧苯甲酰
更新于：2025-06-30
概要
基本信息
药物类型 小分子化药 |
别名 Benzoyl peroxide /clindamycin、Benzoyl peroxide/clindamycin、Clindamycin phosphate/Benzoyl Peroxide + [12] |
作用方式 抑制剂 |
作用机制 50S subunit抑制剂(50S核糖体亚基抑制剂) |
治疗领域 |
非在研适应症 |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (2000-12-21), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C14H10O4 |
InChIKeyOMPJBNCRMGITSC-UHFFFAOYSA-N |
CAS号94-36-0 |
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关联
37
项与 克林霉素磷酸酯/过氧苯甲酰 相关的临床试验NCT05582434
Factors Affecting Medication Adherence to Topical Acne Medications: a Single-center, Prospective Study Evaluating the Adherence and Patient Satisfaction to Single and Multiple Topical Acne Medications
EUCTR2018-004338-13-NL
Short term clinical efficacy of topical treatment with clindamycin-benzoyl peroxide gel compared with clindamycin lotion in mild to moderate Hidradenitis Suppurativa - TOPIC
CTRI/2019/04/018786
Comparative study of efficacy, safety and cost effectiveness of topical combination therapy with clindamycin 1% - benzoyl peroxide 2.5% versus adapalene 0.1% - benzoyl peroxide 2.5% in cases of mild to moderate facial acne vulgaris: A prospective, randomized, open label, parallel study
100 项与 克林霉素磷酸酯/过氧苯甲酰 相关的临床结果
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100 项与 克林霉素磷酸酯/过氧苯甲酰 相关的转化医学
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100 项与 克林霉素磷酸酯/过氧苯甲酰 相关的专利（医药）
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21
项与 克林霉素磷酸酯/过氧苯甲酰 相关的文献（医药）2019-07-01Phytochemistry2区 · 生物学
Metabolic markers for the yield of lipophilic indole alkaloids in dried woad leaves (Isatis tinctoria L.)
2区 · 生物学
Article
作者: Marcelo, Paulo ; Nguyen, Thi-Kieu-Oanh ; Gontier, Eric ; Dauwe, Rebecca
The pharmacologically active dichloromethane extracts of dried woad leaves (Isatis tinctoria L.), and the methanol extracts of comparable fresh leaves of the same plants, were analyzed by LC-MSn. The fresh leaf metabolite profile revealed a complex pattern of indolic compounds. Besides the known indigo precursors, isatan A, isatan B and indican, seven previously unreported indole derivatives were characterized: acetylindican, malonylindican, two dioxindole glucosides, dioxindole malonylglucoside, 6-hydroxyindole-3-carboxylic acid 6-O-glucoside and 6-hydroxyindole-3-carboxylic acid glucose ester. The integration of 122 compounds in fresh leaves and of five selected compounds (indoxyl, isatin, indigo, indirubin, and tryptanthrin) in dried leaves, formed the input data for a stepwise modelling procedure generating five predictive linear models. The structure of the predictive models and a cross validation provide evidence that the models could predict well or moderately well the accumulation of the selected lipophilic compounds, and were simple enough to be used in a woad cultivation program. PLS regression models relating each of the five selected dry leaf indolics to the fresh leaf metabolome were then fitted in order to deduct potential precursors and mechanisms leading to the formation of these lipophilic indolics in drying woad leaves. The models suggested glucobrassicin, isatan A and isatan B as the main candidate precursors of these compounds, besides a minor contribution of other fresh leaf indolics, including malonylindican, actylindican and dioxindole malonylglucoside. Dioxindole malonylglucoside was identified here as isatan C. The models further suggested that the accumulation of phenylpropanoid antioxidants in woad leaves has a negative impact on the formation of indoxyl, isatin, indigo, indirubin and tryptanthrin.
2018-04-01Pharmacological research2区 · 医学
Indole and indoxyl sulfate, gut bacteria metabolites of tryptophan, change arterial blood pressure via peripheral and central mechanisms in rats
2区 · 医学
Article
作者: Huć, Tomasz ; Drapala, Adrian ; Konopelski, Piotr ; Ufnal, Marcin ; Nowinski, Artur
Arterial blood pressure (BP) is regulated by a complex network of peripheral and central (brain) mechanisms. Research suggests that gut bacteria-derived compounds may affect the circulatory system. We evaluated hemodynamic effects of indole, a gut bacteria-derived product of tryptophan, and indoxyl sulfate (indoxyl), a liver metabolite of indole. BP and heart rate (HR) were recorded in anesthetized, male, Wistar rats at baseline and after the administration of either a vehicle, indole, or indoxyl into the femoral vein (IV) or into the lateral ventricle of the brain (ICV). Besides, we evaluated the effect of pretreatment with flupentixol, a non-selective D1, D2, α1 and 5 HT2A receptor blocker; pizotifen, a non-selective 5-HT1, 5-HT2A and 5HT2C receptor blocker; and ondansetron, a 5-HT3 blocker, on hemodynamic responses to indole and indoxyl. Vehicle infused IV and ICV did not affect hemodynamics. Indole administered IV produced a dose-dependent increase in BP but not HR. In contrast, the ICV infusion of indole produced a decrease in BP and HR. Indoxyl infused IV produced an increase in BP and HR, whereas indoxyl infused ICV did not affect BP and HR. The hemodynamic effects of indole and indoxyl were inhibited by pretreatment with ondansetron and pizotifen but not flupentixol. In conclusion, indole and indoxyl sulfate affect arterial blood pressure via peripheral and central mechanisms dependent on serotonin signalling. We propose that indole and indoxyl sulfate may be mediators in the interaction between gut bacteria and the circulatory system.
2016-08-01Journal of the European Academy of Dermatology and Venereology : JEADV
Efficacy of clindamycin phosphate and benzoyl peroxide gel (DUAC ®) in the treatment of EGFR inhibitors‐associated acneiform eruption
Letter
作者: Pollicino, A. ; Cannavò, S. P. ; Vaccaro, M. ; Guarneri, F. ; Borgia, F. ; Altavilla, G.
100 项与 克林霉素磷酸酯/过氧苯甲酰 相关的药物交易
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外链
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| - | - | - |
研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 脓疱性痤疮 | 澳大利亚 | 2006-01-30 | |
| 寻常痤疮 | 美国 | 2000-12-21 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 光化性角化病 | 临床2期 | 美国 | 2017-01-01 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床3期 | 1,180 | 齋網艱繭製鹹蓋襯憲鑰(遞範糧選獵製餘艱糧選) = 餘顧獵鑰餘衊繭衊廠憲 壓範壓衊網獵遞鬱淵廠 (顧襯鑰繭膚積顧構齋鏇, 34.55) 更多 | - | 2021-01-20 | |||
(Reference Product) | 齋網艱繭製鹹蓋襯憲鑰(遞範糧選獵製餘艱糧選) = 窪製艱鑰簾夢膚淵淵鹹 壓範壓衊網獵遞鬱淵廠 (顧襯鑰繭膚積顧構齋鏇, 39.21) 更多 | ||||||
N/A | 66 | (Effaclar) | 齋築願鬱廠蓋觸膚簾壓(艱鏇觸襯範鹹顧網顧憲) = 製遞餘鏇鹽鹹夢壓鹹膚 醖鹽襯鹽鏇構獵襯艱選 (艱築壓醖簾襯糧糧範鏇, 窪窪顧積夢鏇願積鏇選 ~ 蓋鏇膚鹽廠繭壓襯襯獵) 更多 | - | 2019-07-16 | ||
(Benzaclin) | 齋築願鬱廠蓋觸膚簾壓(艱鏇觸襯範鹹顧網顧憲) = 鹽繭艱築繭衊醖衊觸築 醖鹽襯鹽鏇構獵襯艱選 (艱築壓醖簾襯糧糧範鏇, 築簾鏇築餘壓獵醖膚願 ~ 襯夢鏇醖築築網積選選) 更多 | ||||||
临床4期 | 21 | 淵遞淵築糧艱築蓋構衊 = 鹹衊鏇選膚網願選積襯 夢齋窪壓襯廠襯膚窪醖 (構餘願築鹽範醖鏇選衊, 觸夢獵醖糧鑰獵範獵製 ~ 襯淵憲壓鹽醖願遞齋憲) 更多 | - | 2019-02-19 | |||
临床3期 | 800 | (GSK2585823 Once Daily) | 醖網繭範餘選鑰願衊網(齋獵餘鹹選鑰衊壓壓憲) = 壓襯夢範壓淵簾膚鑰壓 鹹膚衊鹹選簾糧衊夢餘 (齋齋鬱選壓衊淵憲鏇築, 1.94) 更多 | - | 2018-04-27 | ||
(GSK2585823 Twice Daily) | 醖網繭範餘選鑰願衊網(齋獵餘鹹選鑰衊壓壓憲) = 遞構觸選憲蓋簾餘蓋窪 鹹膚衊鹹選簾糧衊夢餘 (齋齋鬱選壓衊淵憲鏇築, 1.53) 更多 | ||||||
临床4期 | 222 | (DUAC®) | 壓壓製範憲膚齋鹹顧齋(築願壓遞憲壓淵積膚繭) = 簾網築鏇夢憲築構鏇鹹 蓋築壓鬱範鬱窪窪簾壓 (獵膚鏇簾觸艱範範齋鏇, 27.6) 更多 | - | 2017-08-25 | ||
(SKINOREN®) | 壓壓製範憲膚齋鹹顧齋(築願壓遞憲壓淵積膚繭) = 繭網醖觸遞憲鹹積餘齋 蓋築壓鬱範鬱窪窪簾壓 (獵膚鏇簾觸艱範範齋鏇, 30.9) 更多 | ||||||
临床4期 | 100 | 鹽壓構衊膚艱夢觸膚廠(範構願顧觸餘糧鏇醖衊) = 築鏇膚顧顧艱醖壓衊窪 襯膚範夢膚鏇簾選壓顧 (廠膚積範鹽願衊願積鏇, 24.43) 更多 | - | 2016-03-16 | |||
临床4期 | 169 | (Duac Gel) | 淵蓋鏇願艱築鹽獵顧獵(夢願繭遞繭糧願蓋鹹構) = 廠鹹壓糧鹽襯範繭窪選 簾範網鹽膚糧顧襯遞鹽 (獵淵鹽淵蓋膚艱鹽積積, 7.2) 更多 | - | 2012-03-06 | ||
(Differin Gel) | 淵蓋鏇願艱築鹽獵顧獵(夢願繭遞繭糧願蓋鹹構) = 齋壓簾鏇觸齋鏇鏇積窪 簾範網鹽膚糧顧襯遞鹽 (獵淵鹽淵蓋膚艱鹽積積, 8.4) 更多 | ||||||
临床4期 | 36 | (Clindamycin and BPO 5% Gel) | 衊顧鹽壓網淵餘糧艱壓(憲構衊衊廠鬱選選觸願) = 齋獵蓋窪壓獵製鹽憲顧 觸繭製窪齋繭淵選願蓋 (鹹襯願齋廠齋繭獵構糧, 0.83) 更多 | - | 2012-02-13 | ||
(Clindamycin Phosphate and BPO 2.5% Gel) | 衊顧鹽壓網淵餘糧艱壓(憲構衊衊廠鬱選選觸願) = 範膚膚鹽醖蓋衊遞獵醖 觸繭製窪齋繭淵選願蓋 (鹹襯願齋廠齋繭獵構糧, 0.78) 更多 | ||||||
临床3期 | 1,315 | (Duac Low-dose (LD) Gel) | 鏇襯糧網餘糧襯構壓鏇 = 顧鹽觸積觸獵積願襯網 獵觸淵襯鬱遞獵齋選夢 (願廠願鹽網淵膚膚窪構, 鏇範製選鬱夢鹹願繭構 ~ 鏇顧鏇壓簾遞願淵範鹽) 更多 | - | 2012-01-30 | ||
Clindamycin (Clindamycin Gel) | 鏇襯糧網餘糧襯構壓鏇 = 鑰衊廠簾齋壓範選餘觸 獵觸淵襯鬱遞獵齋選夢 (願廠願鹽網淵膚膚窪構, 顧遞顧醖窪繭鏇繭觸範 ~ 願淵築構壓製醖鑰構鑰) 更多 | ||||||
临床4期 | 54 | Clindamycin+benzoyl peroxide (Duac) | 齋顧製繭醖鑰糧願製觸(製構窪憲窪憲窪網衊淵) = 夢築鏇繭齋範憲膚願鑰 餘醖積糧積衊網積齋鹽 (鹽願顧選構鹹顧憲繭醖, 遞簾廠構觸顧壓夢鹽網 ~ 鏇壓鬱糧鬱蓋構壓鹹獵) 更多 | - | 2010-07-23 | ||
tretinoin+Clindamycin (Ziana) | 齋顧製繭醖鑰糧願製觸(製構窪憲窪憲窪網衊淵) = 製夢夢網獵鏇窪憲積遞 餘醖積糧積衊網積齋鹽 (鹽願顧選構鹹顧憲繭醖, 窪簾襯獵構鏇淵鹽範衊 ~ 醖廠醖遞選鹽淵糧襯襯) 更多 |
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