Benzoyl Peroxide/Clindamycin Phosphate

☝ 点击上方 一键预约 ☝   最新最热的医药健康新闻政策 鉴于5年时限要求，本轮过后将有16款产品无缘明年国谈，有化药、生物药也有中药，有仿制药、改良药也有创新药。这其中多款产品自获批以来并未上市销售，例如“二甲双胍恩格列净片(Ⅳ)”、“二甲双胍恩格列净片(Ⅴ)”、“甲磺酸加诺沙星片”、“克林霉素磷酸酯过氧苯甲酰凝胶”、“蛇床子总香豆素软膏”、“乌美溴铵吸入粉雾剂”。 比较可惜的就是“阿立哌唑口服溶液”，国内15家企业上市并已早早纳入国采，在符合国谈要求的情况下，在最后一年艰难通过形式审查，但也竟不能直接纳入常规目录。 当然还有“二甲双胍恩格列净片(Ⅳ)”、“二甲双胍恩格列净片(Ⅴ)”，国内分别上市1家和4家企业，但限于规格比例不同而不能纳入医保，这毫无疑问会影响到对患者用药方案的调整。 还有那“甲磺酸加诺沙星片”、“克林霉素磷酸酯过氧苯甲酰凝胶”、上市后连商业化都不做，企业开发意义是啥。“可利霉素片”更可惜了，不能纳入医保只能在DTP药房卖一卖，抗生素不纳入医保何时能回收研发成本呢。 此外，今年剔除医保的43个产品终于查全了，被剔除的产品基本属于无销售数据可认为临床不用即没价值的产品。但2款国谈产品此次被剔除属实可惜，尤其是“头孢托仑匹酯颗粒”尚有很多企业在开发仿制。 （来源: 篱笆外边) 药闻康策 新媒体矩阵微信公众号 点击下方  一键关注 【免责声明】 1.“药闻康策”部分文章信息来源于网络转载是出于传递更多信息之目的，并不意味着赞同其观点或证实其内容的真实性。如对内容有疑议，请及时与我司联系。2.“药闻康策”致力于提供合理、准确、完整的资讯信息，但不保证信息的合理性、准确性和完整性，且不对因信息的不合理、不准确或遗漏导致的任何损失或损害承担责任。3.“药闻康策”所有信息仅供参考，不做任何商业交易或医疗服务的根据，如自行使用“药闻康策”内容发生偏差，我司不承担任何责任，包括但不限于法律责任，赔偿责任。 欢迎转发分享、点赞、点在看

TUESDAY, July 16, 2024 -- Being regular is good for you, a new study shows. Predictable bowel movements could be tied to your long-term health, allowing your body to absorb essential nutrients without producing harmful organ-damaging toxins, researchers found. The “Goldilocks zone” of bowel movement frequency, once or twice a day, is associated with better health, results show. That gives gut microbes enough time to digest dietary fiber, which they ferment into beneficial short-chain fatty acids, explained lead researcher Johannes Johnson-Martinez , a doctoral student with the Institute for Systems Biology in Seattle. “After that, the ecosystem switches to fermentation of proteins, which produces several toxins that can make their way into the bloodstream,” Johnson-Martinez explained in an institute news release. For the study, researchers analyzed medical and lifestyle data for more than 1,400 healthy adults, according to the study published July 16 in the journal Cell Reports Medicine. These folks were divided into four groups based on bowel movement frequency -- constipation , low-normal, high-normal and diarrhea . The constipated moved their bowels once or twice a week, low-normal three to six times a week, and high-normal one to three times a day. People with constipation and diarrhea tend to have higher levels of bacteria associated with toxic protein fermentation, results showed. The toxins produced by protein fermentation can cause organ damage, the researchers added. For example, a protein fermentation byproduct called indoxyl-sulfate is significantly associated with reduced kidney function, results show. Blood levels of that byproduct and another toxin called p-cresol-sulfate were elevated in people with constipation. Meanwhile, other toxins associated with liver damage were higher in people with diarrhea. “Chronic constipation has been associated with neurodegenerative disorders and with chronic kidney disease progression in patients with active disease,” said researcher Sean Gibbons , an associate professor with the Institute for Systems Biology. “However, it has been unclear whether or not bowel movement abnormalities are early drivers of chronic disease and organ damage, or whether these retrospective associations in sick patients are merely a coincidence,” Gibbons added. “Here, in a generally healthy population, we show that constipation, in particular, is associated with blood levels of microbially derived toxins known to cause organ damage, prior to any disease diagnosis.” Not surprisingly, people tend to be in the Goldilocks zone if they eat a fiber-rich diet, drink lots of water, and have regular exercise, researchers said. Younger people, women and those with a lower BMI tend to have less frequent bowel movements, results show. Mental health also can affect a person’s bowel movements, results show. “Overall, this study shows how bowel movement frequency can influence all body systems, and how aberrant bowel movement frequency may be an important risk factor in the development of chronic diseases,” Gibbons said. “These insights could inform strategies for managing bowel movement frequency, even in healthy populations, to optimize health and wellness.” Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.