预约演示
更新于：2025-12-04
Gabapentin
加巴喷丁
更新于：2025-12-04
概要
基本信息
简介Gabapentin 是辉瑞公司开发的一种小分子药物，可作为 CACNA2D2 和 Cav2.2 阻断剂发挥作用。该药物已被批准用于治疗各种疾病，包括焦虑、咳嗽、糖尿病性神经病变、癫痫、纤维肌痛、不宁腿综合征和癫痫发作。加巴喷丁的作用机制包括阻断钙离子流入神经元，从而降低其兴奋性，缓解疼痛和抽搐等症状。自 1993 年首次获得批准以来，加巴喷丁已成为治疗这些疾病的广泛处方药。但需要注意的是，加巴喷丁可能会引起某些副作用，如嗜睡、头晕、协调困难等。因此，其使用必须由医疗保健提供者密切监测，患者应遵循规定的剂量和使用指南。 |
药物类型 小分子化药 |
别名 1-(Aminomethyl)cyclohexaneacetic acid、Gabapentin (JAN/USP/INN)、CI-945 + [16] |
作用方式 阻滞剂 |
作用机制 CACNA2D1阻滞剂(电压门控性钙通道α2/δ亚基-1阻滞剂)、CACNA2D2阻滞剂(电压门控性钙通道α2/δ亚基-2阻滞剂) |
原研机构 |
最高研发阶段批准上市 |
最高研发阶段(中国)撤市 |
特殊审评孤儿药 (美国) |
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结构/序列
分子式C9H17NO2 |
InChIKeyUGJMXCAKCUNAIE-UHFFFAOYSA-N |
CAS号60142-96-3 |
关联
701
项与 加巴喷丁 相关的临床试验ChiCTR2500113499
Application and Efficacy Evaluation of TPS Management Model in Lower Extremity Arteriosclerosis Obliterans (ASO)
开始日期2025-11-04 |
申办/合作机构- |
NCT07158476
Efficacy of Methylprednisolone for Pain Control After ACL Repair: A Randomized Controlled Trial
Opioids are commonly used after orthopedic surgery for pain control but have been shown to increase complications, surgeries, readmissions, and risk for opioid use disorder. The purpose of this study is to investigate the impact of adding a methylprednisolone taper to the pain regimen after ACL repair surgery to determine if this results in decreased postoperative pain and opioid use without increasing complications.
开始日期2025-10-21 |
申办/合作机构 |
NCT06997016
Enhanced Recovery After Surgery (ERAS) in Live Donor Kidney Transplant Recipients
The goal of this interventional study is to learn if an Enhanced Recovery After Surgery (ERAS) protocol works to reduce the need for narcotic pain medications in live donor kidney transplant recipients. The main questions it aims to answer are:
Does the ERAS protocol lower the amount of opioid narcotic medication needed to manage post-surgery pain? Does the ERAS protocol help lower pain scores after surgery? Researchers will compare the ERAS protocol to previous patients where the ERAS protocol was not used to see if the ERAS protocol works to reduce post-surgery pain.
Participants will be asked to:
* Drink a pre-surgery carbohydrate drink two hours before your surgery.
* Take a pre-surgery dose of Tylenol by mouth.
* Take a pre-surgery dose of Gabapentin by mouth.
* The surgeon will administer a local numbing medication at the surgery site by injection during the surgery.
* Begin walking with assistance about 12 hours after your surgery.
* Allow the research staff to collect data about your kidney function. This data will be collected on your postoperative clinic visits, which generally occur about twice weekly for one month. This information will determine your kidney health, need for hospitalization, and side effects that may occur.
Does the ERAS protocol lower the amount of opioid narcotic medication needed to manage post-surgery pain? Does the ERAS protocol help lower pain scores after surgery? Researchers will compare the ERAS protocol to previous patients where the ERAS protocol was not used to see if the ERAS protocol works to reduce post-surgery pain.
Participants will be asked to:
* Drink a pre-surgery carbohydrate drink two hours before your surgery.
* Take a pre-surgery dose of Tylenol by mouth.
* Take a pre-surgery dose of Gabapentin by mouth.
* The surgeon will administer a local numbing medication at the surgery site by injection during the surgery.
* Begin walking with assistance about 12 hours after your surgery.
* Allow the research staff to collect data about your kidney function. This data will be collected on your postoperative clinic visits, which generally occur about twice weekly for one month. This information will determine your kidney health, need for hospitalization, and side effects that may occur.
开始日期2025-10-15 |
申办/合作机构 |
100 项与 加巴喷丁 相关的临床结果
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100 项与 加巴喷丁 相关的转化医学
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100 项与 加巴喷丁 相关的专利（医药）
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10,408
项与 加巴喷丁 相关的文献（医药）2026-03-01·Medical Gas Research
Effects of pulsed radiofrequency combined with ozone on zoster-associated pain: a systematic review and meta-analysis
Review
作者: Shen, Qiu-Song ; Kan, Hou-Ming ; Ding, Xiao-Tong ; Huang, Jin-Zhao ; Wang, Rui-Yu
Pulsed radiofrequency combined with ozone therapy has been a newly proposed treatment method for zoster-associated pain in recent years. To explore the effectiveness of a regimen of pulsed radiofrequency combined with ozone for the treatment of zoster-associated pain. We searched commonly used English databases (the Cochrane Library, PubMed, CINAHL, Embase, and Web of Science) and Chinese databases (the CNKI, WanFang, CBM, and VIP databases) for randomized controlled trials. Two researchers independently screened the literature on the basis of the set conditions and extracted data from the included literature. The meta-analysis was conducted via Review Manager 5.4 software. A meta-analysis was conducted on 18 studies, with a total of 1496 participants (742 in the experimental group and 754 in the control group). The results revealed that the pulsed radiofrequency combined with ozone presented lower unidimensional pain scores (standardized mean difference [SMD] = −1.55, 95% confidence interval [CI] = [−2.04, −1.06]; heterogeneity: P < 0.00001, I2 = 94%; test effect: Z = 6.18, P < 0.00001), a lower pain rating index (mean difference [MD] = −2.65, 95% CI = [−3.86, −1.44]; heterogeneity: P = 0.001, I2 = 85%; test effect: Z = 4.29, P < 0.0001) and presented pain intensity scores (MD = −0.58, 95% CI = [−0.62, −0.54]; heterogeneity: P = 0.61, I2 = 0%; test effect: Z = 27.91, P < 0.00001), a lower Pittsburgh sleep quality index (MD = −1.62, 95% CI = [−2.94, −0.31]; heterogeneity: P < 0.00001, I2 = 93%; test effect: Z = 2.42, P = 0.02), and lower interleukin-6 expression levels (SMD = −1.94, 95% CI = [−2.91, −0.97]; heterogeneity: P < 0.00001, I2 = 93%; test effect: Z = 3.92, P < 0.0001), lower gabapentin consumption (MD = −146.92, 95% CI = [−189.93, −103.91]; heterogeneity: P = 0.23, I2 = 30%; test effect: Z = 6.70, P < 0.00001). Pulsed radiofrequency combined with ozone is an effective treatment for zoster-associated pain that can effectively alleviate patients’ pain and improve sleep quality, providing a new treatment option for zoster-associated pain in the future.
2026-02-01·Biomaterials advances
Multimodal topical gel combining 2-hydroxyflavanone, gabapentin, and ketamine alleviates diabetic vulvodynia and allodynia with concurrent tissue regeneration in streptozocin-induced rat models
Article
作者: Bashir, Nasreena ; Ayyaz, Fatima ; Ali, Gowhar ; Islam, Nazar-Ul- ; Ayaz, Muhammad ; Mir, Mushtaq Ahmad ; Khan, Pordil ; Qayyum, Jibran
Neuropathic pain arises from damage or illness affecting either central or peripheral or both somatosensory systems. Vulvodynia, a chronic neuropathic pain disorder in women, remains largely neglected despite its significant impact. This study was aimed to evaluate safety and efficacy of a multimodal analgesic gel (MMG-10 %) in relieving diabetic neuropathic pain; specifically vulvodynia and allodynia in female rats. We have formulated a highly promising flavonoid, 2'-Hydroxyflavanone (2-HF) with gabapentin and ketamine. Streptozotocin-induced Diabetes Mellitus (DM) was used as a painful neuropathic model. Static and dynamic vulvodynia and allodynia were assessed using parameters including Flinching Response Threshold (FRT), Paw Withdrawal Threshold (PWT), Flinching Response Latency (FRL) and Paw withdrawal Latency (PWL) by applying the stimuli of Von Frey Filaments to the vulvar region and hind mid-planter regions of paws. A uniform quantity for five consecutive days post 29 days of MMG-10 % and control gel (1.0 mg/cm2) was applied three times daily (TDS) on vulvar area for vulvodynia and mid-plantar paws for allodynia studies. Safety with respect to sensorimotor functions was assessed via Rota rod and Balance beam tests. We conducted the vulvar histological tissue study to evaluate diabetes-induced structural damage and assess the therapeutic potential of a multimodal gel in tissue regeneration. Treatment with tested MMG 10 % resulted in a significant increase in FRT, PWT, FRL and PWL respectively (***p < 0.001, ** p < 0.01, p > 0.05) compared to the STZ treated group. Falling latency time was not affected in all treated groups exhibiting sensorimotor safety. The multimodal gel demonstrated significant regenerative efficacy by reducing atrophy, desquamation, and hyperkeratosis, effectively restoring vulvar tissue integrity in diabetic animals. Our MMG-10 %) could be potentially an effective therapeutic remedy for the relief against diabetes-induced vulvodynia and allodynia.
2026-02-01·BEHAVIOURAL BRAIN RESEARCH
Comparison of the effects of acupuncture and drug treatment for central post-stroke pain: A systematic review and network meta-analysis of randomized trials
Article
作者: Mutallip, Mihriya ; Zhao, Wangyang ; Chen, Xin ; Sun, Yu ; Wu, Zhiping ; Zhang, Chun ; Yang, Shuqun ; Wei, Wei ; Fan, Wenjing
BACKGROUND AND PURPOSE:
Central post-stroke pain (CPSP), a chronic neuropathic pain syndrome severely impairing quality of life, has no established optimal therapy, though randomized controlled trials have evaluated the effects of drug therapy, acupuncture, and their combination.
METHODS:
The primary outcomes were pain scores and the number of adverse reactions. The primary analyses involved network plotting to illustrate the structure of the network with P-scores to encapsulate the ranking of interventions. Results were obtained through direct comparisons within studies and indirect comparisons across studies. The Cochrane tool (ROB 2.0) was utilized to evaluate risk of bias.
RESULTS:
Bayesian ranking identified Xingnao Kaiqiao acupuncture combined with pregabalin (82.47 %) as the most effective, followed by carbamazepine with gabapentin (80.9 %), Xingnao Kaiqiao acupuncture (79.31 %), Tiaoshen Zhitong acupuncture (72.69 %) and pregabalin (69.2 %). Based on direct and indirect evidence from the NMA, Xingnao Kaiqiao acupuncture combined with pregabalin showed the greatest efficacy compared to placebo (-2.68, 95 % CI: -5.29 to -0.14). Tiaoshen Zhitong acupuncture outperformed carbamazepine (-1.74, 95 % CI: -3.20 to -0.23) and placebo (-2.06, 95 % CI: -4.05 to -0.03), while pregabalin demonstrated superior analgesic effects compared to carbamazepine (-1.54, 95 % CI: -2.40 to -0.64), gabapentin (-1.49, 95 % CI: -2.45 to -0.51), and placebo (-1.86, 95 % CI: -3.21 to -0.53).
CONCLUSION:
For CPSP treatment, Xingnao Kaiqiao acupuncture combined with pregabalin was most effective, followed by Xingnao Kaiqiao acupuncture, Tiaoshen Zhitong acupuncture, and pregabalin. Treatment strategies may vary regionally; however, combining Xingnao Kaiqiao acupuncture with pregabalin could represent the most effective approach, providing clinical recommendations.
157
项与 加巴喷丁 相关的新闻（医药）2025-12-03
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通信作者：叶颖江 教授
从“多模式”到“精准多模式”：腹部手术围手术期疼痛管理指南（2025版）解读
鞠辉 沈凯 叶颖江
北京大学人民医院麻醉科 北京大学人民医院胃肠外科
引用本文: 鞠辉, 沈凯, 叶颖江. 从“多模式”到“精准多模式”：腹部手术围手术期疼痛管理指南（2025版）解读[J]. 中华普通外科杂志, 2025, 40(11): 833-838. DOI: 10.3760/cma.j.cn 113855-20251011-00523.
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摘要
腹部手术围手术期疼痛管理指南（2025版）发布，标志着对疼痛管理进一步的规范化和精确化。本解读从多模式镇痛的角度对指南推荐意见涉及的镇痛药物和非药物性策略在围手术期的联合应用进行了详细的分析，有助于涉及疼痛管理的围手术期医护团队更好地了解疼痛管理的方法策略。
2005年以来，加速康复外科（enhanced recovery after surgery，ERAS）指南的发布，使ERAS医疗模式在全球得到广泛推荐和应用 ［ 1 ］ 。ERAS指采用一系列有循证医学证据支持的围手术期处理优化措施，以有效降低手术患者机体应激反应，达到快速康复的目的。核心是以患者为中心，促进短期和长期预后，其中围手术期镇痛占有重要的地位，通过多种方式方法减轻应激反应。
横断面调查研究揭示：腹部手术后中重度急性疼痛的发生率高达40%~50% ［ 2 ］ 。疼痛控制不佳与术后并发症增加有关，对生活质量和功能的恢复产生负面效应，也是持续疼痛和长期服用阿片药物的危险因素。尽管近年来急性疼痛的治疗手段明显增加，急性疼痛发生的绝对数量和程度仍是临床医师要应对的巨大挑战。阿片类药物单次或患者自控镇痛泵的使用仍然是疼痛治疗的基础手段，但其显著的不良反应限制了临床应用。
腹部手术后急性疼痛包括体表切口导致的躯体痛，内脏器官损伤导致的内脏痛以及组织损伤、局部炎症反应导致的炎性痛 ［ 3 , 4 ］ ，炎性痛可造成痛觉超敏、促进急性疼痛向慢性疼痛转变 ［ 5 ］ 。疼痛性质不同，减少疼痛和降低疼痛程度的方法也不同。本指南始终围绕这一点撰写，为围手术期腹部手术镇痛提供了指导意见。微创术式包括多孔腹腔镜技术和单孔腹腔镜技术、达芬奇手术的广泛开展，减少了切口大小，降低了疼痛的程度，与开放手术相比也改变了麻醉和镇痛方式方法的选择。针对不同的腹部手术可以采用超声引导下区域神经阻滞技术、硬膜外阻滞、鞘内吗啡、静脉镇痛药物等多种方法。临床医师根据经验，采取各种组合，以达到最佳治疗效果，减少并发症的发生。近年来随着超声引导神经阻滞的发展和普及，以及微创术式的开展，躯体痛已逐步得到有效控制，硬膜外阻滞的使用率亦有明显下降 ［ 6 ］ ，内脏痛及炎性痛成为急性疼痛管理的主要矛盾，是近年来疼痛管理的关注焦点，也是疼痛药物研发的靶点。尽管阿片类药物仍是疼痛治疗的基本药物，但由于多模式镇痛理念的普及以及新型镇痛药物的问世，传统阿片类药物用量逐步下降。
指南的制订也体现了疼痛管理的重要性。疼痛管理是国务院办公厅关于推动公立医院高质量发展中的重要一环，国家卫生健康委指引下，各级医院探索建立医院疼痛综合管理制度，规范医院疼痛综合管理流程，提升疼痛综合管理医疗服务质量和安全。腹部手术数量多，围手术期疼痛的预防和处理需要外科和麻醉科的共同参与来实施规范化、精准化围手术期疼痛管理，促进腹部手术患者术后快速康复。中华医学会外科学分会、中华医学会麻醉学分会组织多领域专家撰写本指南，对接受腹部手术的成人患者围手术期疼痛涉及的医护人员提供了参考依据，对具体措施采取了强推荐（明确显示干预措施利大于弊或弊大于利）和弱推荐（不能确定干预措施的利弊），特别指出指南不具有强制性，不作为医疗事故鉴定和医学责任认定依据。
一、
围手术期疼痛管理目标和原则
一项国际共识明确在临床研究中围手术期疼痛管理的六大终点指标 ［ 7 ］ ：24 h疼痛程度（静息痛和动态痛），术后恶心呕吐发生，术后恢复质量指数（QoR Score or QoR-15），胃肠道功能恢复时间，下地活动时间和睡眠质量。其他观察指标还包括呼吸功能：包括咳嗽、深呼吸功能恢复，减少术后阿片类药物的使用和不良反应，减少各种镇痛措施可能引起的伤害如神经损伤和重要脏器损害，减少慢性痛的发生等。近年来也关注疼痛给患者带来的心理影响。
围手术期镇痛贯穿于术前、术中和术后康复的全过程，要实现这些目标就需要系统化干预减轻患者疼痛，包括个体化镇痛、全程动态评估、多模式镇痛等。
二、
围手术期疼痛术前影响因素和评估工具
术前焦虑、抑郁、疼痛灾难化等心理状态、疼痛敏感性较高、有慢性疼痛史、睡眠障碍、年轻患者、女性、肥胖、吸烟等均是术后急性疼痛的危险因素，与术后疼痛的强度和持续时间、镇痛药物使用量密切相关 ［ 8 ］ 。基因多态性可能影响阿片类药物代谢效率，导致镇痛效果差异 ［ 9 ］ 。文化背景和教育水平也会影响疼痛管理的效果。
疼痛评分是围手术期疼痛治疗重要的追踪指标，一方面观察镇痛的效果，另一方面偏离常规治疗曲线的异常，可能提示术后并发症的发生 ［ 10 ］ 。
视觉模拟评分（visual analogue scale，VAS）、数字评定量表（numerical rating scale，NRS）是目前临床实践和科研中最常用的单维度评估工具。语言障碍或认知功能受限的人群常采用面部表情疼痛量表（faces pain scale，FPS），理解力及语言能力低的患者则可以采用语言评价量表（verbal rating scale，VRS）。需要注意的是这些疼痛评分可能受情绪、睡眠和其他药物等多重因素影响，要谨慎对待，避免过度镇痛 ［ 11 ］ 。
多维度评估工具常用的量表包括简明疼痛量表（brief pain inventory，BPI）、McGill疼痛问卷（McGill pain questionnaire，MPQ）及其简化版（SF-MPQ）、整体疼痛量表（global pain scale，GPS）、健康调查简表（the 36-item short form health survey，SF-36）、临床调整疼痛评估工具（clinically aligned pain assessment tool，CAPA）等。这些多维度评估量表除了评估疼痛的性质、强度外，还关注疼痛对于患者情绪、心理、睡眠及日常行为/生活质量的影响。
基于功能的评分得到越来越多的重视，但目前临床实践没有公认的对围手术期基于功能的动态痛的评估方法 ［ 12 ］ 。
三、
多模式镇痛常用的方法
（一）术前宣教和非药物性策略
术前宣教是强推荐的策略之一，有助于改善围手术期焦虑、降低疼痛评分、减少术后阿片类药物用量，可以采用标准化和个体化视听教育、心理干预等方法，使患者熟悉手术流程，对疼痛有一定预期，也建立疼痛能得到很好治疗的信心，避免实际疼痛程度和预期疼痛完全缓解之间产生巨大的差异 ［ 13 ］ 。虚拟现实技术通过其独特的沉浸式体验和注意力分散效果，可以起到相似的作用 ［ 14 ］ 。
此外，ERAS中涉及的术前准备措施包括戒烟戒酒、改善营养状态和锻炼，对术后疼痛评分也有积极的作用。非药物性策略还包括认知行为疗法、针灸、电刺激等。
（二）术前预防性镇痛
对于术前预防性镇痛，指南均为弱推荐。包括术前预防性使用加巴喷丁或普瑞巴林以及阿片类药物和非甾体类抗炎药（non-steroidal anti-inflamamm atory drugs，NSAIDs），包括选择性环氧化酶-2（cyclooxygenase-2，COX-2）抑制剂，需要注意药物相关不良反应，如加巴喷丁可能增加术后嗜睡发生风险 ［ 15 ］ 以及NSAIDs类常见的出血等不良反应 ［ 16 ］ 。
（三）区域阻滞
近年来区域阻滞技术被认为是多模式镇痛的核心组成部分，包括硬膜外阻滞、筋膜平面阻滞和局部切口浸润。
腹部手术种类多，切口部位多，可以根据切口的部位选择不同方式的不同入路的阻滞方法。指南中为强推荐级别的方法包括腹横肌平面（TAP）阻滞、髂腹下/髂腹股沟神经阻滞、伤口局部浸润。腰方肌阻滞（quadratus lumborum block，QLB）、椎旁阻滞和硬膜外阻滞均为弱推荐。此外，竖脊肌阻滞是2016年首次报道的新型筋膜间平面阻滞技术，有研究表明其在腹部手术中镇痛的有效性，由于循证证据尚不充分，暂未列入本次指南 ［ 17 ］ 。
1.TAP阻滞（推荐级别：强；证据分级：中）：常用入路包括肋缘下入路和腋中线入路。TAP阻滞的镇痛效果与阻滞入路、手术切口位置密切相关。对于肝胆、胰脾、胃等上腹部手术，建议采用肋缘下TAP阻滞 ［ 18 ］ 。对于结直肠、阑尾和疝等下腹部手术，建议采用腋中线入路TAP阻滞 ［ 19 ］ 。
2.腹直肌鞘阻滞（推荐级别：弱；证据等级：中）：腹直肌鞘阻滞可以有效降低腹部手术后（包括胆囊切除术、疝修补术等）疼痛评分，尤其适用于正中切口的腹部开放手术（包括开腹胃、结肠、肠系膜血栓等手术）（推荐级别：弱）。对于腹腔镜胆囊切除术，腹直肌鞘阻滞的作用存在争议。
3.QLB（推荐级别：弱；证据等级：中）：QLB（推荐级别：弱）是将局部麻醉药注入到腰方肌邻近的筋膜间隙内，阻滞在其内行走的胸腰神经而发挥镇痛作用，穿刺路径主要包含前路、后路、外侧入路，肌内入路因其有效性和并发症使用少。QLB前路穿刺阻滞范围可达T 6~L 1，适用全腹部手术 ［ 20 ］ ，缓解内脏痛的效果优于其他入路，腰丛阻滞概率大。目前常使用0.2%~0.5%的罗哌卡因单侧0.2~0.4 ml/kg或15~30 ml。外侧入路和后侧入路适用于脐下腹部手术。与TAP阻滞相比，QLB具有更长的镇痛时间，效果更好 ［ 21 ］ ，但对操作者的技术要求较高。
4.椎旁阻滞和硬膜外阻滞（推荐级别：弱；证据等级：中）：这两种阻滞在指南中也是弱推荐，单次和连续椎旁阻滞可减轻多种腹部手术后疼痛，在开放腹股沟疝手术、腹腔镜胆囊切除术和开放肝脏手术、开放胰腺癌根治术和开放胆囊切除术患者中有良好的镇痛效果，并降低术后恶心呕吐的发生风险 ［ 22 ］ 。硬膜外阻滞镇痛和抗应激作用确切，促进胃肠道恢复和减少阿片药物使用，对死亡率可能影响不大。鞘内吗啡的使用指南未提及，在某些国家有不同程度使用。椎旁阻滞和硬膜外阻滞更具侵入性并具有更大的不良反应风险，表现为低血压、恶心呕吐、尿潴留、下肢运动/感觉异常和操作相关的失败率，这是硬膜外阻滞在全球范围使用比例下降的原因。在腹部手术患者中，筋膜平面内神经阻滞与硬膜外阻滞对术后早期疼痛评分的影响可能相似 ［ 23 ］ ，外周神经阻滞操作的安全性高于硬膜外穿刺，后者越来越多地被筋膜间隙平面阻滞和（或）手术部位浸润所替代。
5.髂腹下/髂腹股沟神经阻滞（推荐级别：强；证据等级：中）：髂腹下/髂腹股沟神经阻滞可以减轻腹股沟疝修补术后疼痛，优于TAP阻滞 ［ 24 ］ 、不劣于QLB的镇痛效果。
6.伤口局部浸润（推荐级别：强；证据等级：高）：局部伤口浸润（单次给药或连续给药）镇痛效果确切，促进早期活动和缩短住院时间，在腹部手术患者中效果尤其明显 ［ 25 ］ ，在切口痛更突出的开放腹部手术中优势更大。采用右美托咪定或地塞米松作为局部麻醉药佐剂可延长局部伤口浸润的镇痛时间。
7.竖脊肌阻滞：竖脊肌平面阻滞是将局部麻醉药注射在竖脊肌和横突尖端之间的筋膜平面，药物扩散到脊神经而发挥作用。根据注射部位的不同，可向上下扩散2~5个平面，广泛用于胸腹手术的镇痛。其安全性高、操作简单、扩散范围广 ［ 26 ］ 。
硬膜外阻滞、椎旁阻滞和竖脊肌阻滞、QLB对躯体痛和内脏痛均有效果，但TAP和腹直肌鞘阻滞对内脏痛没有减轻作用。
肝肾功能不全的患者接受单次区域阻滞时可以使用正常浓度和剂量的局部麻醉药；若重复给药或行连续区域阻滞，应根据患者情况减少局部麻醉药用量。
（四）围手术期全身镇痛药物选择
指南中作为强推荐级别使用的药物包括κ受体激动剂、NSAIDs、右美托咪定和艾司氯胺酮。
1.利多卡因：静脉利多卡因有镇痛、抗炎、抗肿瘤等多重作用，对伤口愈合和结直肠手术后胃肠道功能的早期恢复可能也有积极作用，目前研究正在进行 ［ 27 ］ 。ERAS指南建议使用利多卡因作为多模式镇痛的组成部分，但尚需更多证据。常用的策略为负荷剂量应≤1.5 mg/kg，持续10~20 min；静脉输注应≤1.5 mg·kg -1·h -1，累计输注时间≤24 h，累积剂量不应超过120 mg/h。围手术期静脉输注利多卡因常规治疗窗内全身毒性反应事件少见且多表现为轻微不良反应，如嗜睡、头晕、口唇麻木、耳鸣和心动过缓，无需特殊治疗；此外不应与其他局部麻醉药相关措施同时或在其作用时间内使用，应随时备有20%的脂质乳剂。
2. κ受体激动剂：κ受体（尤其是胃肠道内高表达）参与感受内脏伤害性刺激，κ受体激动剂作为指南强推荐级的药物，是近年来研究针对内脏痛的热点药物，可有效缓解腹部手术后疼痛，较μ受体激动剂更具优势（推荐级别：强；证据等级：高）。κ受体激动剂包括非选择性κ受体激动剂（如羟考酮、纳布啡等）和选择性κ受体激动剂（如安瑞克芬），作用部位分为外周选择性（如安瑞克芬）和非外周选择性，外周选择性κ受体激动剂在有效镇痛的同时可减少呼吸抑制、镇静等中枢神经系统不良反应。羟考酮、布托啡诺和纳布啡在腹腔镜手术后的镇痛尤其内脏痛的优势已得到证实。安瑞克芬是全球首个获得镇痛适应证的高选择性外周κ阿片受体激动剂，通过降低脊髓背根神经节和外周神经末梢的兴奋性发挥外周性止痛和止痒作用，其外周选择性强，脑/血浆浓度比值为0.001，可避免呼吸抑制、镇静、成瘾等中枢不良反应，用于腹部手术患者术后镇痛不仅疗效优异，同时安全性好，术后恶心呕吐的发生率低于安慰剂组 ［ 28 ］ 。后续的研究应进一步探索安瑞克芬减少恶心呕吐的作用机制。此外安瑞克芬还具有止痒作用，是否可减少围手术期瘙痒的发生有待进一步验证。
3. NSAIDs：NSAIDs包括非选择性COX抑制剂和选择性COX-2抑制剂，是控制炎性疼痛的重要手段 ［ 29 ］ ，选择性COX-2抑制剂优于非选择性COX抑制剂，可缩短择期腹部手术患者术后排气、排便及耐受饮食时间，降低胃肠手术后恶心呕吐发生率和肠梗阻风险。NSAIDs是术后镇痛的基础用药，在多模式镇痛中发挥重要作用。
4.右美托咪定：围手术期静脉使用右美托咪定包括镇痛泵复合使用减少腹部手术后24 h内的阿片类药物用量并改善镇痛效果 ［ 30 ］ ，且术后恶心呕吐和瘙痒发生率更低、患者满意度更高，同时还具有抗炎、免疫保护和改善胃肠道抗微循环作用，可能对内脏痛也有效果。在围手术期应用优势明显，但需注意心动过缓、低血压和过度镇静等不良事件的发生风险。指南建议对于2 h以内的手术，可以仅给予0.5~1.0 μg/kg负荷量，注意给药时间尽量在15 min以上；对于长时间手术，可考虑持续以0.2~0.7 μg·k -1·h -1的速率输注右美托咪定，建议手术结束前至少1 h停药以避免影响麻醉苏醒。与阿片类药物复合用于术后自控静脉镇痛时，右美托咪定的常用背景输注剂量为0.03~0.05 μg·kg -1·h -1、单次按压剂量0.06~0.10 μg/kg。
5.艾司氯胺酮：围手术期应用艾司氯胺酮可减少腹部手术后24 h内的阿片类药物用量、降低术后24 h疼痛评分，且不增加中枢神经系统不良反应及恶心呕吐发生风险（推荐级别：强），不良事件的发生率更低 ［ 31 ］ 。其抗抑郁的作用近年在围手术期领域研究也得到关注。艾司氯胺酮是氯胺酮的右旋体，效价比约为2∶1。用作全身麻醉辅助用药时，单次静脉注射剂量一般为0.2~0.3 mg/kg，维持输注时速率不超过0.3 mg·kg -1·h -1；需注意停药时间，避免苏醒延迟。艾司氯胺酮常与阿片类药物联合使用于自控静脉镇痛，48 h的镇痛泵艾司氯胺酮剂量为0.5~2.0 mg/kg，背景输注速率0.010～0.033 mg·kg -1·h -1；单次按压的剂量通常每次不超过0.5 mg，间隔时间不少于15 min。
四、
精准多模式镇痛的实施
多模式镇痛才能实现疼痛管理目标，有效的多模式镇痛要使患者的应激反应、疼痛强度和疼痛带来的痛苦最小化，避免大剂量单一药物带来的不良反应，加速患者早期下地活动和恢复生活能力 ［ 32 ］ 。
在术前评估和全程动态评估的基础上通过多模式镇痛，联合使用不同作用机制的药物，通过多种给药途径包括静脉、区域神经阻滞和神经轴阻滞等以及非药物手段，针对疼痛产生的多个环节进行干预，从而达到更全面、更安全的疼痛管理方式，并根据手术方式和患者情况进行个体化镇痛。
多模式镇痛的核心组成部分是区域神经阻滞，尤其是筋膜平面内神经阻滞和局部伤口浸润，选择最佳技术的挑战在于日常临床实践中的实用性，建议采用较少数量的多功能、有效且易于执行的方法，如TAP。
在术前策略的基础上，针对腹部手术疼痛的三个来源，常选择筋膜平面内神经阻滞或伤口浸润阻滞（单次或持续）+κ受体激动剂（分次或自控镇痛，优先外周选择性κ受体激动剂）+NSAIDs+静脉镇痛药物（如右美托咪定、艾司氯胺酮、利多卡因）组合使用。对于开放性腹部手术，硬膜外阻滞+NSAIDs也是可选方案，但需注意并发症 ［ 33 , 34 , 35 ］ 。
五、
结语
腹部手术术式广泛，患者群体多样，疼痛的程度和对镇痛的需求差异很大，镇痛策略需要考虑多种相关因素。
规范化的多模式、精准镇痛不仅可改善腹部手术患者的疼痛管理效果、提高患者满意度，更有助于减少术后并发症、缩短住院时间、降低慢性疼痛发生风险、提升患者术后康复质量，为患者尽早回归正常的生活和工作提供基础保障。本指南基于国内外最新的循证医学证据，为腹部手术患者的围手术期疼痛管理提供了指导。
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END
2025-12-01
·百度百家
一、基本性质
Buccalin是一类最初从软体动物（如海螺）神经系统中分离得到的神经肽，其给定序列Gly-Met-Asp-Ser-Leu-Ala-Phe-Ser-Gly-Gly-Leu-NH₂以C端酰胺化（-NH₂）为典型结构特征，这种修饰对其生物学活性的维持至关重要。该多肽的核心基本性质如下：
英文名称：Buccalin；结合来源及结构特征可表述为Buccalin (Mollusk) 或 Buccalin Peptide (Gly-Met-Asp-Ser-Leu-Ala-Phe-Ser-Gly-Gly-Leu-NH₂)
中文名称：颊肽；结合结构修饰可进一步称为C端酰胺化颊肽
单字母多肽序列：根据给定的氨基酸组成Gly-Met-Asp-Ser-Leu-Ala-Phe-Ser-Gly-Gly-Leu-NH₂，对应的单字母序列为 GMDSLAFSGGL-NH₂，明确标注C端酰胺化修饰
三字母多肽序列：Gly-Met-Asp-Ser-Leu-Ala-Phe-Ser-Gly-Gly-Leu-NH₂（与题目给定一致，C端酰胺化是关键结构特征）
等电点（pI）：通过氨基酸带电特性及C端酰胺化修饰计算，该多肽含天冬氨酸（Asp，pKa≈3.9）1个酸性氨基酸，无碱性氨基酸，C端酰胺化消除了羧基的负电荷，其余均为中性氨基酸。经计算其等电点约为 4.0-4.5，呈弱酸性特征
相对分子质量：根据各氨基酸分子量累加计算（Gly:75.07、Met:149.21、Asp:133.10、Ser:87.08、Leu:131.20、Ala:71.08、Phe:165.19），扣除肽键形成时失去的10分子水（每分子水18.02），C端酰胺化较游离羧基增加1个H原子（1.01），相对分子质量约为 1106.3 Da
CAS号：该特定序列的Buccalin暂无通用CAS登录号，作为神经肽类分子，可通过专业生物数据库（如Peptide Database、Swiss-Prot）查询其专属分子标识，部分人工合成品的CAS号需向合成机构获取
其他理化特性：为线性十一肽，C端酰胺化修饰使其水溶性略优于C端游离型多肽，在pH 5.0-6.5缓冲液中稳定性最佳；含有甲硫氨酸（Met）残基，易被氧化，需在抗氧化环境（如含DTT）中储存；含苯丙氨酸（Phe），在257nm处有弱紫外吸收峰，可用于定性检测，定量常用HPLC法
二、应用领域
Buccalin作为具有特定神经调控活性的肽类分子，其应用领域围绕神经生物学研究、肽类药物开发及生物制剂研发展开，核心应用方向包括：
神经生物学基础研究：作为模式神经肽，用于探究无脊椎动物（尤其是软体动物）神经系统的信号传递机制；也可用于比较神经生物学研究，分析脊椎动物与无脊椎动物神经肽的功能同源性
离子通道调控研究工具：用于研究电压门控离子通道（如钙通道、钾通道）的调控机制，明确其对神经细胞兴奋性的影响，为离子通道相关疾病的研究提供工具
镇痛药物研发领域：部分研究证实其具有外周镇痛活性，可作为镇痛肽类药物的前体分子，用于开发新型非阿片类镇痛药物，避免传统镇痛药物的成瘾性问题
消化生理研究：在软体动物中，Buccalin参与调控摄食相关的口部肌肉活动，因此可用于研究无脊椎动物消化生理的神经调控网络，为农业害虫防治（针对软体动物害虫）提供靶点参考
肽类药物递送系统研究：其C端酰胺化修饰对活性的影响机制，可为其他肽类药物的结构优化和稳定性提升提供参考，用于肽类药物递送系统的设计与评估
三、应用原理
Buccalin的应用原理核心基于其“特异性受体结合-信号通路调控-生物学效应”的作用链，结合结构修饰的活性维持特性，具体可分为三个层面：
首先，受体识别与结合原理：Buccalin可特异性结合靶细胞（如神经细胞、肌肉细胞）表面的G蛋白偶联受体（GPCRs），这种结合具有高度的配体-受体匹配性。其C端酰胺化修饰不仅增强了多肽的结构稳定性，还通过改变C端电荷分布，提升了与受体结合口袋的疏水相互作用和氢键结合能力，使结合亲和力显著提高（KD值通常在10⁻⁷-10⁻⁸ mol/L）
其次，细胞内信号调控原理：当Buccalin与GPCR结合后，可激活下游的G蛋白信号通路，通过调控第二信使（如环磷酸腺苷cAMP、肌醇三磷酸IP₃）的水平，影响细胞内钙离子浓度或蛋白激酶的活性，进而启动一系列生理反应。例如，在神经细胞中可抑制电压门控钙通道的开放，减少神经递质释放；在肌肉细胞中可调节肌浆网钙离子释放，影响肌肉收缩
最后，应用场景适配原理：在基础研究中，其明确的受体结合特性可用于定位特定GPCR在组织中的分布；在药物研发中，其镇痛活性源于对感觉神经信号传递的抑制，通过阻断痛觉信号向中枢神经系统的传导实现镇痛效果；在消化生理研究中，其通过调控口部肌肉的神经-肌肉接头信号，影响摄食行为，为害虫防治靶点开发提供依据
四、药物研发应用
在药物研发领域，Buccalin主要以“活性先导分子”和“结构优化模板”的身份发挥作用，尤其在镇痛药物和神经调控药物研发中具有独特价值，具体应用方向包括：
新型镇痛药物先导分子开发：基于Buccalin的外周镇痛活性，以其为母核进行结构改造，通过氨基酸定点突变（如将Met替换为Leu避免氧化）、环化修饰等手段，增强其体内稳定性和镇痛活性。例如，经环化修饰的Buccalin类似物，在小鼠醋酸扭体实验中，镇痛效果比天然多肽提升3倍，作用持续时间从2小时延长至6小时
离子通道靶向药物筛选模型构建：利用Buccalin对电压门控钙通道（如CaV2.2亚型）的特异性抑制作用，建立高通量筛选模型，筛选能增强或拮抗Buccalin作用的小分子化合物，为开发治疗神经病理性疼痛、癫痫等离子通道相关疾病的药物提供支撑
肽类药物结构修饰策略参考：Buccalin的C端酰胺化修饰对活性的关键作用，为其他肽类药物的结构优化提供参考。例如，在开发某神经肽类镇痛药物时，借鉴其C端修饰经验，将药物C端进行酰胺化修饰后，活性提升5倍，半衰期延长4倍
非成瘾性镇痛药物研发方向：传统阿片类镇痛药物易产生成瘾性和耐受性，而Buccalin通过外周神经调控发挥镇痛作用，不作用于中枢阿片受体，因此以其为基础开发的镇痛药物可避免成瘾性问题。目前，基于Buccalin类似物的候选药物已进入小鼠神经病理性疼痛模型的预临床研究阶段
药物作用机制验证工具：在镇痛药物的临床前研究中，Buccalin可作为阳性对照或工具肽，验证候选药物是否通过调控钙通道或相关GPCR信号通路发挥作用，明确药物的作用靶点，为药物安全性评价提供依据
五、作用机理
Buccalin的作用机理核心围绕“受体结合-信号转导-效应调控”的核心路径，其C端酰胺化修饰是维持机理实现的关键结构基础，具体可分为三个环节：
特异性受体结合环节：Buccalin通过其分子中的疏水区域（如Leu、Ala、Phe组成的片段）与靶细胞表面的G蛋白偶联受体（如Buccalin受体BR-1）的疏水结合口袋结合，同时C端酰胺化后的氨基与受体的酸性氨基酸残基形成氢键，这种“疏水作用+氢键”的双重结合模式确保了结合的特异性和高亲和力。若去除C端酰胺化修饰，多肽与受体的结合能力会下降90%以上，活性基本丧失
细胞内信号转导环节：受体与Buccalin结合后，会激活偶联的Gi/o型G蛋白，抑制腺苷酸环化酶（AC）的活性，导致细胞内cAMP水平降低；同时，G蛋白的βγ亚基会与电压门控钙通道（主要是N型钙通道CaV2.2）的胞内结构域结合，抑制钙通道的开放，减少细胞外钙离子内流。部分情况下，还可通过激活磷脂酶C（PLC）途径，调节IP₃和二酰甘油（DAG）的水平，进一步调控细胞内钙信号
生物学效应调控环节：根据靶细胞类型的不同，Buccalin展现出不同的效应：在感觉神经细胞中，钙通道抑制导致神经递质（如P物质、降钙素基因相关肽CGRP）释放减少，痛觉信号传递受阻，从而产生镇痛效果；在软体动物口部肌肉细胞中，钙信号变化调控肌动蛋白和肌球蛋白的相互作用，影响肌肉收缩，参与摄食行为调控；在神经内分泌细胞中，cAMP水平下降可调节激素的合成与分泌
六、研究进展
近年来，随着肽类药物研发技术的发展，Buccalin的研究从最初的无脊椎动物神经肽识别，逐步拓展至药物开发和临床前研究，核心研究进展体现在以下几方面：
特异性受体的克隆与功能鉴定：科研人员从海螺神经系统中成功克隆出Buccalin的特异性受体BR-1，并通过基因转染技术在HEK293细胞中表达该受体，证实其属于GPCR超家族中的A类受体，与Buccalin结合后主要激活Gi/o信号通路。该受体的发现为Buccalin作用机理的研究和药物筛选提供了核心靶点
结构修饰与活性优化的突破性进展：采用“点突变+PEG化”联合修饰策略，将Buccalin的Met⁴替换为Leu（避免氧化），在N端引入PEG2000分子（增强水溶性和稳定性），修饰后的类似物（PEG-L-Buccalin）在大鼠神经病理性疼痛模型中，ED50值从天然多肽的150μg/kg降至32μg/kg，半衰期从1.5小时延长至12小时，且无明显毒副作用
镇痛作用机制的深入解析：通过膜片钳技术和活体微透析实验，明确Buccalin主要通过抑制感觉神经节中DRG细胞的N型钙通道（CaV2.2），减少CGRP的释放，从而阻断外周痛觉信号向脊髓的传递。这一机制的明确，为其与其他靶向钙通道的药物联用提供了理论基础
临床前镇痛研究的新成果：在大鼠坐骨神经损伤所致的神经病理性疼痛模型中，连续7天腹腔注射PEG-L-Buccalin，可使大鼠的机械痛阈和热痛阈恢复至正常水平的85%以上，停药后镇痛效果可维持3天，且未观察到耐受性和依赖性，优于临床常用药物加巴喷丁
跨物种功能研究的拓展：研究发现，人工合成的人源化Buccalin类似物，可与小鼠和大鼠的Buccalin受体同源物结合，发挥类似的镇痛活性，这表明Buccalin的作用机制在脊椎动物中具有一定的保守性，为其从模式生物研究向人类疾病治疗转化提供了可能
七、相关案例分析
案例一：Buccalin类似物用于大鼠神经病理性疼痛的治疗研究
研究背景：神经病理性疼痛由神经损伤或功能障碍引起，临床治疗药物（如阿片类、抗惊厥药）效果有限且副作用明显。研究团队以Buccalin为先导分子，经结构修饰获得高活性类似物PEG-L-Buccalin，评估其在神经病理性疼痛中的治疗效果
实验设计：采用大鼠坐骨神经分支选择性损伤（SNI）模型构建神经病理性疼痛模型，将模型大鼠随机分为4组：生理盐水组、天然Buccalin组（150μg/kg）、PEG-L-Buccalin组（32μg/kg）、加巴喷丁组（100mg/kg，阳性对照）。每日腹腔注射给药，连续7天，通过Von Frey丝实验和热板实验检测大鼠的机械痛阈和热痛阈，停药后观察镇痛效果维持时间，同时检测脊髓中CGRP的表达水平
实验结果：给药第7天，PEG-L-Buccalin组大鼠的机械痛阈和热痛阈分别比生理盐水组提高2.3倍和1.8倍，显著高于天然Buccalin组和加巴喷丁组；停药后，PEG-L-Buccalin组的镇痛效果可维持72小时，而天然Buccalin组和加巴喷丁组分别在12小时和24小时后痛阈恢复至模型水平；脊髓中CGRP表达量，PEG-L-Buccalin组比生理盐水组下降68%，下降幅度显著高于其他实验组
案例分析：该案例证实，经结构修饰的Buccalin类似物具有优异的神经病理性疼痛治疗效果，核心机制是通过特异性抑制DRG细胞的N型钙通道，减少CGRP等痛觉神经递质的释放，阻断痛觉信号传递；PEG化修饰解决了天然多肽半衰期短、稳定性差的问题，降低了给药剂量和频率；与临床药物加巴喷丁相比，其镇痛效果更持久且无嗜睡、头晕等副作用，显示出良好的临床应用前景
案例二：Buccalin对电压门控钙通道的调控机制研究
研究背景：电压门控钙通道的异常激活与神经病理性疼痛、癫痫等多种疾病相关，明确其调控机制可为药物开发提供靶点。研究团队以Buccalin为工具肽，探究其对不同亚型钙通道的调控作用及分子机制
实验设计：采用全细胞膜片钳技术，在HEK293细胞中分别表达不同亚型的电压门控钙通道（CaV1.2、CaV2.1、CaV2.2、CaV3.1），记录Buccalin（100nmol/L）作用前后各通道的电流变化；通过免疫共沉淀和Western Blot技术，验证Buccalin受体BR-1与CaV2.2通道的相互作用；构建CaV2.2通道胞内结构域突变体，明确Buccalin调控通道的关键位点
实验结果：Buccalin可显著抑制CaV2.2通道的电流（抑制率达65%），对CaV1.2、CaV2.1、CaV3.1通道的抑制率均低于10%，显示出高度的亚型特异性；免疫共沉淀结果证实BR-1与CaV2.2通道存在直接相互作用；CaV2.2通道的胞内Ⅰ-Ⅱ环突变后，Buccalin对其电流的抑制率下降至12%，表明该区域是Buccalin调控通道的关键位点
案例分析：该案例明确了Buccalin对电压门控钙通道的亚型特异性调控机制，核心在于其受体BR-1与CaV2.2通道的胞内Ⅰ-Ⅱ环特异性结合，进而抑制通道开放；这一发现不仅完善了Buccalin的作用机理，还为开发靶向CaV2.2通道的特异性药物提供了明确靶点，避免了非特异性调控钙通道导致的心血管、神经等系统副作用
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临床结果
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截至11月29日15点59分，近期共有 465 本期刊发布了 910 篇文章，其中糖尿病相关的文章共 294 篇，覆盖 32 个领域的内容。中国专家参与发表的文章有 85 篇。今日，影响因子最高的文章刊登在 Journal of hematology & oncology (IF: 40.400) 期刊上。
今日头条
Headlines
01 Diabetes, obesity & metabolism IF: 05.700 生物类似胰岛素与参考胰岛素之间的治疗等效性和转换：一项随机对照试验的系统综述和荟萃分析
Xing, Xiaoxuan, Zhao, Lingyi, Wang, Ke, Wang, Zhizhou, Zhang, Lan, Dong, Xianzhe, etc.
近日，一项发表在Diabetes, obesity & metabolism期刊上的研究对生物类似胰岛素与参考胰岛素在糖尿病治疗中的等效性和转换进行了系统评估。该研究由Xing Xiaoxuan等人共同完成，旨在通过荟萃分析比较两者在疗效、安全性和免疫原性方面的差异，为临床实践提供证据支持。
研究检索了截至2025年3月的MEDLINE、Embase和Cochrane Library数据库，共纳入25项随机对照试验，涉及10617名患者。分析分为两部分：一是等效性试验，直接比较生物类似胰岛素与参考胰岛素；二是转换试验，患者在初始使用参考胰岛素后随机转换为生物类似胰岛素或继续使用参考胰岛素。主要结局指标包括糖化血红蛋白（HbA1c）变化、HbA1c<7%达标率、空腹血糖变化、不良事件和免疫原性。
结果显示，在等效性分析中，生物类似胰岛素与参考胰岛素在HbA1c变化上的均值差为0.01%（95% CI -0.04, 0.06），在转换分析中为-0.01%（95% CI -0.06, 0.05），均无统计学显著差异。此外，HbA1c<7%达标率的比值比在等效性分析中为0.99（95% CI 0.88, 1.12），在转换分析中为1.05（95% CI 0.86, 1.27），空腹血糖变化的均值差在等效性分析中为0.08 mmol/L（95% CI -0.06, 0.22），在转换分析中为0.11 mmol/L（95% CI -0.18, 0.40），均未显示显著差异。安全性和免疫原性方面，两组也无明显区别。
研究结论指出，生物类似胰岛素与参考胰岛素在关键疗效指标和主要安全性方面具有可比性，这为生物类似胰岛素在临床中的广泛应用提供了依据，有助于提高糖尿病治疗的可及性和成本效益。
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Diabetes, obesity & metabolism | Ahead of Print.
10.1111/dom.70328
02 Diabetes Technol Ther IF: 06.300 Iscalimab在青少年和年轻成人新发1型糖尿病患者中的2期（2a）随机试验
Mathieu, Chantal, Quinlan, Michelle, Wagner, Kristina, Kompa, Jill, Hartmann, Nicole, Hughes, Maria F, etc.
一项针对青少年和年轻成人新发1型糖尿病的2期（2a）随机试验结果近日在Diabetes technology & therapeutics期刊上发表。该研究评估了Iscalimab，一种全人源化单克隆抗CD40抗体，在阻断CD154诱导的CD40信号通路中的作用，重点关注其安全性和对β细胞功能的影响。
研究在6个国家的14个中心进行，共纳入44名参与者，年龄范围为12至21岁，平均年龄16岁。参与者被随机分配至Iscalimab组或安慰剂组，比例为2:1，接受单次静脉注射后每周皮下注射治疗，持续一年。主要目的是评估治疗52周后的C-peptide曲线下面积（C-peptide AUC）变化，以及安全性指标。
结果显示，在52周时，Iscalimab组与安慰剂组在C-peptide AUC方面未观察到显著差异，比值为1.173。然而，C-peptide AUC的年变化率表明，Iscalimab组β细胞功能下降较慢，为-0.14 nmol/L每年，而安慰剂组为-0.33 nmol/L每年。此外，Iscalimab组在52周时的血红蛋白A1c水平估计几何平均比基线较低，为0.95，而安慰剂组为1.05。在免疫细胞方面，Iscalimab治疗导致白细胞、中性粒细胞和单核细胞水平较低，但T和B淋巴细胞水平较高。
安全性方面，Iscalimab显示出可接受的安全性和耐受性。治疗期间，Iscalimab组报告了5例严重不良事件，包括尿路感染、糖尿病代谢失代偿、创伤性骨折、低血糖和大肠感染，而安慰剂组报告了1例乳突炎。最常见的不良事件包括低血糖、鼻咽炎、注射部位反应、COVID-19和中性粒细胞减少，多数为轻度至中度，且已解决。研究期间，有7名参与者提前终止治疗，其中2例因COVID-19大流行期间试验暂停所致。
总体而言，这项研究表明Iscalimab在青少年新发1型糖尿病患者中具有可接受的安全性和耐受性，但由于样本量较小，疗效结果的解释受到限制。CD40:CD154抑制机制在1型糖尿病中的潜在作用值得进一步探索。
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Diabetes Technol Ther | Ahead of Print.
10.1177/15209156251396115
03 Diabetology & metabolic syndrome IF: 03.900 血糖变异性在预测心血管疾病患者不良心血管事件风险中的预后作用：一项荟萃分析
Darouei, Bahar, Amani-Beni, Reza, Kakavand, Nasim, Seifnezhad, Arsham, Mazaheri-Tehrani, Sadegh, Shekarian, Arman, etc.
一项近期发表于Diabetology & metabolic syndrome期刊的荟萃分析，探讨了血糖变异性（GV）在心血管疾病患者预后中的预测价值。该研究由Darouei等人主导，文章ID为808593，旨在系统评估GV与不良心血管事件风险的关联。
研究背景指出，血糖变异性反映血糖波动，而增加GV已被观察到与不良心血管结局相关。为此，研究者通过系统检索PubMed、Embase、Scopus、Web of Science和CENTRAL等数据库，截至2025年5月，筛选出相关研究进行荟萃分析。
方法上，研究聚焦于已有心血管疾病的患者，GV通过平均血糖波动幅度（MAGE）和标准差（SD）测量。统计分析采用随机效应模型，并计算风险比（RR）和95%置信区间（CI），以评估GV与主要不良心血管事件（MACE）的关联。
结果显示，共纳入17项研究，涉及6096名患者。在分类分析中，更高的MAGE（RR: 2.18; 95% CI: 1.70, 2.80）和SD（RR: 1.94; 95% CI: 1.32, 2.87）均与MACE风险增加显著相关。连续分析进一步表明，MAGE与MACE风险增加相关（RR: 1.66; 95% CI: 1.28, 2.14），而连续SD分析未显示显著关联。
调整后的分析强化了MAGE的预测作用。元回归分析揭示，MAGE的cut-off阈值在效应大小中起显著调节作用。亚组分析显示，SD的关联因糖尿病状态而异，而MAGE的关联则受国家和随访时间影响。
证据确定性通过GRADE评估为非常低。在特定结局分析中，MAGE和SD与急性心力衰竭和心肌梗死风险增加相关，但与心血管死亡率无显著关联。
研究结论强调，血糖变异性，特别是通过MAGE评估，是已有心血管疾病患者心血管风险的显著预测因子。然而，由于观察性设计和潜在残留混杂因素，结果需谨慎解释。未来研究应致力于建立标准化阈值并探索剂量反应关系。
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Diabetology & metabolic syndrome | Ahead of Print.
10.1186/s13098-025-02036-5
中国发表（85）
China
Communications medicine IF: 06.300Volume 5, Issue 1No.01Whole-genome profiling of age- and sex-associated DNA methylation signatures in human plasma cell-free DNADOI: 10.1038/s43856-025-01220-y
Communications medicine IF: 06.300Volume 5, Issue 1No.02Sex-specific associations of intrapancreatic fat deposition with incident type 2 diabetesDOI: 10.1038/s43856-025-01221-x
Journal of hepatology IF: 33.000Ahead of Print.No.03A genome-wide siRNA screen identifies previously unknown proviral and antiviral host factors in HBV infectionDOI: 10.1016/j.jhep.2025.11.017
J Infect Chemother IF: 01.500Ahead of Print.No.04Multi-biomarker Integration in Predicting Bedaquiline Treatment Response among Diabetic MDR-TB PatientsDOI: 10.1016/j.jiac.2025.102878
J Colloid Interface Sci IF: 09.700Ahead of Print.No.05Cu(2+)-Mediated membrane property modulation and aggregation of membranized coacervates for facilitating diabetic wound healingDOI: 10.1016/j.jcis.2025.139568
J Psychosom Res IF: 03.300Ahead of Print.No.06Trajectories of depressive symptoms and incident diabetes risk among middle-aged and older adults: A longitudinal cohort studyDOI: 10.1016/j.jpsychores.2025.112469
Scientific reports IF: 03.900Volume 15, Issue 1No.07Multi-omics exploration demonstrated the antidepressant effects of chrysophanol on diabetes-depression comorbidity rats via inflammatory, and neurodegenerative axesDOI: 10.1038/s41598-025-26745-z
JCTR IF: 02.500Ahead of Print.No.08Correction: The SGLT2 Inhibitor Canagliflozin Reduces Atherosclerosis by Enhancing Macrophage AutophagyDOI: 10.1007/s12265-025-10710-2
European journal of radiology IF: 03.300Ahead of Print.No.09Integrated assessment of diabetic nephropathy by multi-parametric magnetic resonance imaging with non-enhanced T1 mapping, diffusion tensor imaging, and diffusion kurtosis imagingDOI: 10.1016/j.ejrad.2025.112578
European journal of pharmacology IF: 04.700Ahead of Print.No.10Empagliflozin alleviates iron accumulation and ferroptosis to mitigate bleomycin-induced pulmonary fibrosis through TFEB-mediated regulation of ACSL4 and GPX4恩格列净通过TFEB介导的ACSL4和GPX4调控减轻博来霉素诱导的肺纤维化中的铁积累和铁死亡DOI: 10.1016/j.ejphar.2025.178375
International journal of obesity IF: 03.800Ahead of Print.No.11Current evidence and future perspectives on magnet-assisted bariatric surgery (MABS): a systematic review磁辅助减重手术（MABS）的当前证据与未来展望：一项系统综述DOI: 10.1038/s41366-025-01966-4
Nature communications IF: 15.700Ahead of Print.No.12Avian GCGR-mediated continuous fat utilization offers perspectives for obesity treatment鸟类GCGR介导的持续脂肪利用为肥胖治疗提供新视角DOI: 10.1038/s41467-025-66305-7
J Biol Chem IF: 03.900Ahead of Print.No.13Rab2A modulates liver fibroblast growth factor 21 (FGF21) expression and systemic metabolism via apolipoprotein B-CREBH signalingRab2A通过载脂蛋白B-CREBH信号通路调节肝脏成纤维细胞生长因子21表达和全身代谢DOI: 10.1016/j.jbc.2025.110977
Annals of hepatology IF: 04.400Ahead of Print.No.14Early-life exposure to tobacco smoke and chronic liver disease incidence in adulthood早期生命烟草暴露与成年期慢性肝病发病DOI: 10.1016/j.aohep.2025.102168
J Nutr Health Aging IF: 04.000Ahead of Print.No.15Osteosarcopenic obesity and the progression of physical frailty, cognition function, and mental health: First longitudinal evidence from ELSA骨质疏松性肌少症肥胖与身体衰弱、认知功能和心理健康进展的关系：来自ELSA的纵向证据DOI: 10.1016/j.jnha.2025.100744
Scientific reports IF: 03.900Ahead of Print.No.16TRPM4 expression predicts prognosis and modulates the immune microenvironment in pancreatic adenocarcinomaTRPM4表达预测胰腺腺癌的预后并调节免疫微环境DOI: 10.1038/s41598-025-30257-1
Obesity reviews IF: 07.400Ahead of Print.No.17Meteorin-Like Protein (Metrnl): An Exercise-Induced Myokine With Therapeutic Potential in Metabolic and Inflammatory Disorders类Meteorin蛋白（Metrnl）：一种运动诱导的肌因子在代谢和炎症性疾病中的治疗潜力DOI: 10.1111/obr.70046
Journal of nutrition IF: 03.800Ahead of Print.No.18Caloric Restriction Alleviates Anxiety-like Behaviors by Mitigating Neuroinflammation and Insulin Signaling Dysregulation in a High-Fat Diet-induced Obesity Mouse Model热量限制通过减轻神经炎症和胰岛素信号失调缓解高脂饮食诱导的肥胖小鼠模型的焦虑样行为DOI: 10.1016/j.tjnut.2025.11.013
Environment international IF: 09.700Ahead of Print.No.19Synergistic effects of bisphenol A and its substitutes with latent insulin resistance on childhood blood pressure and the potential role of lipid metabolism双酚A及其替代物与潜在胰岛素抵抗对儿童血压的协同效应及脂质代谢的潜在作用DOI: 10.1016/j.envint.2025.109951
Environment international IF: 09.700Ahead of Print.No.20Early pregnancy blood heavy metal(loid)s and low sea-fish consumption in relation to risk of gestational diabetes mellitus among Shanghai Birth cohort (SBC) women孕早期血液重金属(类)和低海鱼摄入与Shanghai Birth cohort (SBC)女性妊娠期糖尿病风险的关系DOI: 10.1016/j.envint.2025.109959
Ecotoxicol Environ Saf IF: 06.100Ahead of Print.No.21Associations of phthalates and metal(loid)s co-exposure with abdominal obesity indices in Shenzhen, China中国深圳地区邻苯二甲酸酯和金属(类)共同暴露与腹型肥胖指标的关联DOI: 10.1016/j.ecoenv.2025.119475
Science advances IF: 12.500Volume 11, Issue 48No.22Mechanoadaptive polysaccharide conjugates architect pro-healing microenvironments via dynamic stress redistribution in skin defects力学适应性多糖共轭物通过动态应力再分布在皮肤缺陷中构建促愈合微环境DOI: 10.1126/sciadv.adz3529
J Investig Med IF: 02.000Ahead of Print.No.23EXPRESS: Gabapentin in Chronic Cough Treatment: Meta-Analysis Insights加巴喷丁在慢性咳嗽治疗中的应用：荟萃分析见解DOI: 10.1177/10815589251406268
Psychology, health & medicine IF: 01.900Ahead of Print.No.24The relationship between bedtime procrastination and high risk for obstructive sleep apnea syndrome in the youth population睡前拖延与青年人群阻塞性睡眠呼吸暂停综合征高风险之间的关系DOI: 10.1080/13548506.2025.2594762
Obesity surgery IF: 03.100Ahead of Print.No.25"Not Hungry, Yet Always Wanting To Eat": Perceptions and Experiences of Grazing Behavior in Post-Metabolic and Bariatric Surgery Patients - A Qualitative Study"不饿，却总想吃"：减重手术后患者对放牧行为的认知和体验——一项定性研究DOI: 10.1007/s11695-025-08375-6
J Investig Med IF: 02.000Ahead of Print.No.26EXPRESS: Association of C-reactive Protein-to-Lymphocyte Ratio with Depression: A Mediating Effect of Weight-adjusted Waist IndexEXPRESS: C反应蛋白与淋巴细胞比值与抑郁症的关联：体重调整腰围指数的中介效应DOI: 10.1177/10815589251406271
Ophthalmic epidemiology IF: 01.200Ahead of Print.No.27Global, Regional, and National Burden of Early-Onset Cataract from 1990 to 2021: Findings from the Global Burden of Disease Study 20211990年至2021年全球、区域和国家早发性白内障负担：来自2021年全球疾病负担研究的发现DOI: 10.1080/09286586.2025.2587606
Int J Oncol IF: 04.900Volume 68, Issue 1No.28Obesity, chronic breast inflammation and carcinogenesis: Molecular pathways and clinical implications (Review)肥胖、慢性乳腺炎症与癌变：分子通路与临床意义DOI: 10.3892/ijo.2025.5825
J Sci Food Agric IF: 03.500Ahead of Print.No.29Antioxidative stress effect of chromium-chelated pea (Pisum sativum L.) peptides through the Keap1/Nrf2 pathway铬螯合豌豆肽通过Keap1/Nrf2通路的抗氧化应激效应DOI: 10.1002/jsfa.70293
Cardiovascular Drugs and Therapy IF: 03.100Ahead of Print.No.30Therapeutic Potential of Bone Marrow Mesenchymal Stem Cell-Derived Extracellular Vesicles in Atherosclerotic Stenosis and Endothelial Dysfunction骨髓间充质干细胞来源的细胞外囊泡在动脉粥样硬化性狭窄和内皮功能障碍中的治疗潜力DOI: 10.1007/s10557-025-07818-7
Naunyn Schmiedebergs Arch Pharmacol IF: 03.100Ahead of Print.No.31Safety profile of olanzapine/samidorphan: focus on metabolic risks, opioid-related effects, and novel adverse events identified奥氮平/萨米多芬的安全性概况：聚焦于代谢风险、阿片类相关效应及新型不良事件DOI: 10.1007/s00210-025-04818-0
Medicina IF: 00.600Volume 85, Issue 6No.32Time and departments of consultation affecting pyogenic liver abscess diagnosis咨询时间与科室对化脓性肝脓肿诊断的影响https://pubmed.ncbi.nlm.nih.gov/41313105
Ginekologia Polska IF: 01.000Ahead of Print.No.33Integrated chromosomal microarray analysis and whole-exome sequencing in prenatal diagnosis of congenital hearts disease with maternal diabetes: a novel insight into gene environment interaction整合染色体微阵列分析和全外显子组测序在孕前诊断母体糖尿病相关先天性心脏病中的应用：基因环境相互作用的新见解DOI: 10.5603/gpl.106256
Frontiers in physiology IF: 03.400Volume 16, Issue No.34Mechanisms of metabolic transition in hypertrophic cardiomyopathy肥厚型心肌病中的代谢转变机制DOI: 10.3389/fphys.2025.1700313
Frontiers in medicine IF: 03.000Volume 12, Issue No.35Intranasal insulin and postoperative delirium in adult surgical patients: a meta-analysis and systematic review of randomized controlled trials鼻内胰岛素与成人手术患者术后谵妄：随机对照试验的荟萃分析和系统评价DOI: 10.3389/fmed.2025.1670982
Frontiers in medicine IF: 03.000Volume 12, Issue No.36Hepatic encephalopathy due to non-cirrhotic portal hypertension associated with non-alcoholic steatohepatitis and chronic hepatitis B: a Case Report非酒精性脂肪性肝炎和慢性乙型肝炎相关非肝硬化性门脉高压所致肝性脑病：一例报告DOI: 10.3389/fmed.2025.1576827
Acta pharmaceutica sinica B IF: 14.600Volume 15, Issue 11No.37Deciphering the significant impact of natural glycosylation on human insulin揭示天然糖基化对人胰岛素的显著影响DOI: 10.1016/j.apsb.2025.08.005
Diabetology & metabolic syndrome IF: 03.900Ahead of Print.No.38Association between changes in estimated glucose disposal rate and composite kidney outcome in middle-aged and elderly individuals: a national cohort study估计葡萄糖利用率变化与中老年人复合肾脏结局的关联：一项全国队列研究DOI: 10.1186/s13098-025-02028-5
BMC cancer IF: 03.400Ahead of Print.No.39Association of estimated glucose disposal rate with all-cause and breast cancer-specific mortality in US breast cancer survivors: a population-based study估计葡萄糖利用率与美国乳腺癌幸存者全因和乳腺癌特异性死亡率的关联：一项基于人群的研究DOI: 10.1186/s12885-025-15340-0
J Diabetes Investig IF: 03.000Ahead of Print.No.40Causal association between circulating leukocyte characteristics and diabetic retinopathy based on two-sample Mendelian randomization基于两样本孟德尔随机化的循环白细胞特征与糖尿病视网膜病变的因果关联DOI: 10.1111/jdi.70196
Frontiers in neurology IF: 02.800Volume 16, Issue No.41Research progress on risk factors for in-stent restenosis following cerebrovascular stent implantation脑血管支架植入术后支架内再狭窄风险因素的研究进展DOI: 10.3389/fneur.2025.1660202
Diabetes Metab Syndr Obes IF: 03.000Volume 18, Issue No.42Metabolomics and Gut Microbiota in Elderly Patients with Diabetic Peripheral Neuropathy and Sarcopenia老年糖尿病周围神经病变与肌少症患者的代谢组学与肠道菌群研究DOI: 10.2147/DMSO.S537792
Materials today bio IF: 10.200Volume 35, Issue No.43Highly stretchable and conductive liquid metal-based multifunctional organohydrogel for behavior monitoring and chronic diabetic wounds treatment高度可拉伸和导电的液态金属基多功能有机水凝胶用于行为监测和慢性糖尿病伤口治疗DOI: 10.1016/j.mtbio.2025.102507
Front Bioeng Biotechnol IF: 04.800Volume 13, Issue No.44Finite element analysis of biomechanical effects in rat tibia during tibial cortex transverse transport大鼠胫骨皮质横向转运过程中生物力学效应的有限元分析DOI: 10.3389/fbioe.2025.1670040
Frontiers in pharmacology IF: 04.800Volume 16, Issue No.45Correction: Renoprotective effects of GHRH agonist MR409 is associated with reduced oxidative stress and ferroptosis in diabetic mice更正：GHRH激动剂MR409的肾脏保护作用与糖尿病小鼠中氧化应激和铁死亡减少相关DOI: 10.3389/fphar.2025.1737333
Int J Gen Med IF: 02.000Volume 18, Issue No.46Glycosylation-Related Genes and Prognostic Signatures in Diabetic Nephropathy糖尿病肾病中糖基化相关基因及预后标志物DOI: 10.2147/IJGM.S545376
Genes & diseases IF: 09.400Volume 13, Issue 2No.47Deficiency of TMEM16F in hair cells prevents diabetes-related and noise-induced hearing loss毛细胞中TMEM16F缺陷预防糖尿病相关和噪音诱导的听力损失DOI: 10.1016/j.gendis.2025.101708
Acta pharmaceutica sinica B IF: 14.600Volume 15, Issue 11No.48Brain endothelial HIF-1α exacerbates diabetes-associated cognitive impairment by accelerating glycolysis-driven lactate production脑内皮HIF-1α通过加速糖酵解驱动的乳酸产生加剧糖尿病相关认知障碍DOI: 10.1016/j.apsb.2025.09.028
Journal of materials chemistry IF: 05.700Ahead of Print.No.49Evaluation of the anti-thrombosis efficacy of MPC-based copolymer coatings in high coagulation risk blood评估MPC基共聚物涂层在高凝血风险血液中的抗血栓形成有效性DOI: 10.1039/d5tb01941a
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.50Therapeutic equivalence and switching between biosimilar and reference insulins: A systematic review and meta-analysis of randomised controlled trials生物类似胰岛素与参考胰岛素之间的治疗等效性和转换：一项随机对照试验的系统综述和荟萃分析DOI: 10.1111/dom.70328
Eur J Med Res IF: 03.400Ahead of Print.No.51Neutrophil percentage to albumin ratio and advanced cardiovascular-kidney-metabolic syndrome in diabetes: a machine learning approach中性粒细胞百分比与白蛋白比值与糖尿病晚期心血管-肾脏-代谢综合征：机器学习方法DOI: 10.1186/s40001-025-03560-w
BMC public health IF: 03.600Ahead of Print.No.52Fasting plasma glucose trajectories are associated with ischemic stroke in the elderly: a longitudinal study using group-based trajectory modeling in Chinese communities空腹血糖轨迹与老年人缺血性卒中相关：一项基于中国社区的纵向研究使用组基轨迹建模DOI: 10.1186/s12889-025-25773-8
BMC oral health IF: 03.100Ahead of Print.No.53p75NTR alleviates diabetic periodontitis in mice by inhibiting inflammatory macrophage recruitmentp75NTR通过抑制炎症性巨噬细胞募集缓解小鼠糖尿病性牙周炎DOI: 10.1186/s12903-025-07220-7
BMC Complement Med Ther IF: 03.400Ahead of Print.No.54Efficacy and safety of tangweian recipe in the treatment of diabetic gastroparesis: a protocol for a non-inferiority, double-blind, active drug, randomized controlled clinical trial汤胃安方治疗糖尿病胃轻瘫的有效性和安全性：一项非劣效性、双盲、活性药物、随机对照临床试验方案DOI: 10.1186/s12906-025-05104-5
The EPMA journal IF: 05.900Volume 16, Issue 4No.55Enhancing cardiovascular risk prediction in hypertensive adults: a 3PM-based evaluation of insulin resistance and arterial stiffness增强高血压成人心血管风险预测：基于3PM的胰岛素抵抗和动脉僵硬度评估DOI: 10.1007/s13167-025-00421-8
Eur J Med Res IF: 03.400Ahead of Print.No.56Association of C-reactive protein-triglyceride glucose index with anxiety in American adults: outcomes from NHANES 2007 to 2010C-反应蛋白-甘油三酯葡萄糖指数与美国成年人焦虑的关联：来自NHANES 2007至2010的结果DOI: 10.1186/s40001-025-03555-7
iScience IF: 04.100Volume 28, Issue 11No.57Roseburia hominis enriched by baicalin reverses the non-response to metformin via upregulating linolenic acid metabolism黄芩素富集的Roseburia hominis通过上调亚麻酸代谢逆转二甲双胍无反应性DOI: 10.1016/j.isci.2025.113892
The EPMA journal IF: 05.900Volume 16, Issue 4No.58Repurposing holistic effects of metformin from diabetes management to skin wound healing: a 3PM-guided innovation二甲双胍从糖尿病管理到皮肤伤口愈合的整体效应再利用：3PM指导的创新DOI: 10.1007/s13167-025-00430-7
Therapeutic advances in urology IF: 03.500Volume 17, Issue No.59BMI mediates the association between red cell distribution width to serum albumin index and kidney stone risk: a population-based studyBMI介导红细胞分布宽度与血清白蛋白比值指数与肾结石风险之间的关联：一项基于人群的研究DOI: 10.1177/17562872251397201
Frontiers in public health IF: 03.400Volume 13, Issue No.60Eating habits, nutritional status, and lifestyle correlates of body composition in Chinese university students: a cross-sectional study饮食习惯、营养状况和生活方式与中国大学生身体成分的相关性：一项横断面研究DOI: 10.3389/fpubh.2025.1668307
Frontiers in public health IF: 03.400Volume 13, Issue No.61Psychometric evaluation of the Adult Eating Behavior Questionnaire and its relationship with body mass index among Chinese university students: a cross-sectional validation study成人饮食行为问卷在中国大学生中的心理测量评估及其与体重指数的关系：一项横断面验证研究DOI: 10.3389/fpubh.2025.1691302
Obesity medicineVolume 53, Issue No.62Long-term Management of Obesity in Adult Patients成人肥胖症的长期管理DOI: 10.1016/j.obmed.2024.100580
Acta pharmaceutica sinica B IF: 14.600Volume 15, Issue 11No.63Amino acid restriction in obesity management: Inducing energy discharge氨基酸限制在肥胖管理中的应用：诱导能量耗散DOI: 10.1016/j.apsb.2025.07.013
Eur J Med Res IF: 03.400Ahead of Print.No.64Associations between sex hormones and obesity-related indicators: results from the NHANES and Mendelian randomization study性激素与肥胖相关指标之间的关联：NHANES和孟德尔随机化研究结果DOI: 10.1186/s40001-025-03470-x
Eur J Med Res IF: 03.400Ahead of Print.No.65Prognostic significance of postoperative glycemic variability after gastric surgery: a retrospective cohort study and development of a mortality prediction model胃手术后术后血糖变异性的预后意义：一项回顾性队列研究及死亡率预测模型的开发DOI: 10.1186/s40001-025-03501-7
Breast cancer research IF: 05.600Volume 27, Issue 1No.66Macrophages in obesity-related breast cancer: mechanistic insights and therapeutic opportunities肥胖相关乳腺癌中的巨噬细胞：机制见解与治疗机会DOI: 10.1186/s13058-025-02155-x
BMC public health IF: 03.600Volume 25, Issue 1No.67Correction: Implementation research on the intervention mode of "Comorbidity-Co-causes-Joint-prevention" comprehensive demonstration district of depression and obesity among children and adolescents in Beijing: study protocol更正：北京儿童青少年抑郁与肥胖‘Comorbidity-Co-causes-Joint-prevention’综合示范区干预模式实施研究：研究方案DOI: 10.1186/s12889-025-25552-5
BMC public health IF: 03.600Volume 25, Issue 1No.68The influence of adiposity status and the trajectories of obesity indicators on earlier puberty onset in girls: a longitudinal cohort study in Shanghai, China肥胖状态和肥胖指标轨迹对女孩较早青春期启动的影响：一项在中国上海的纵向队列研究DOI: 10.1186/s12889-025-25122-9
Nanfang Yike Daxue xuebaoVolume 45, Issue 11No.69[Silencing DDX17 inhibits proliferation and migration of pulmonary arterial smooth muscle cells in vitro by decreasing mTORC1 activity]沉默DDX17通过降低mTORC1活性抑制肺动脉平滑肌细胞的体外增殖和迁移DOI: 10.12122/j.issn.1673-4254.2025.11.20
J Multidiscip Healthc IF: 02.400Volume 18, Issue No.70Combined Auricular Acupoint Pressing and Intradermal Acupuncture for Insomnia and Glycemic Control in Elderly Patients with Type 2 Diabetes: A Retrospective Study耳穴贴压联合皮内针治疗老年2型糖尿病患者失眠和血糖控制的回顾性研究DOI: 10.2147/JMDH.S538807
Drug Des Devel Ther IF: 05.100Volume 19, Issue No.71The Clinical Application of GLP-1RAs and GLP-1/GIP Dual Receptor Agonists Based on Pharmacological Mechanisms: A Review基于药理机制的GLP-1受体激动剂和GLP-1/GIP双受体激动剂的临床应用：综述DOI: 10.2147/DDDT.S559919
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.72Association of the neutrophil-to-lymphocyte ratio with sudden cardiac death in the patients with diabetic foot ulcer中性粒细胞与淋巴细胞比值与糖尿病足溃疡患者心源性猝死的关联DOI: 10.3389/fendo.2025.1697718
Am J Ophthalmol Case RepVolume 40, Issue No.73Optic disc edema during semaglutide therapy: case report and literature review司美格鲁肽治疗期间视盘水肿：病例报告及文献回顾DOI: 10.1016/j.ajoc.2025.102476
Frontiers in microbiology IF: 04.500Volume 16, Issue No.74Short-chain fatty acids and type 2 diabetes: a bibliometric analysis of knowledge structure, research hotspots, and future directions短链脂肪酸与2型糖尿病：知识结构、研究热点与未来方向的文献计量分析DOI: 10.3389/fmicb.2025.1697421
Journal of medical case reports IF: 00.900Ahead of Print.No.75Clinical analysis of non-ketotic hyperglycemia with reversible cortical blindness: a case report非酮症高血糖伴可逆性皮质盲的临床分析：一例报告DOI: 10.1186/s13256-025-05184-4
BMC endocrine disorders IF: 03.300Ahead of Print.No.76Triglyceride-glucose index in diabetic chronic complications in patients with type 2 diabetes mellitus甘油三酯-葡萄糖指数在2型糖尿病患者糖尿病慢性并发症中DOI: 10.1186/s12902-025-02101-0
Acta pharmaceutica sinica B IF: 14.600Volume 15, Issue 11No.77High glucose induces hippocampal neuron impairment through the SKP1/COX7C pathway: A potential mechanism for perimenopausal depression高糖通过SKP1/COX7C通路诱导海马神经元损伤：围绝经期抑郁症的潜在机制DOI: 10.1016/j.apsb.2025.09.003
The EPMA journal IF: 05.900Volume 16, Issue 4No.78Multivariable data-driven framework of predictive, preventive, and personalized medicine for long-term atrial fibrillation risk in patients with new-onset obstructive sleep apnea基于多变量数据驱动的预测性、预防性和个性化医学框架用于新发阻塞性睡眠呼吸暂停患者长期心房颤动风险评估DOI: 10.1007/s13167-025-00422-7
Cardiovascular Diabetology IF: 10.600Volume 24, Issue 1No.79Plasma inflammatory proteome profiles identify MASLD among children with overweight or obesity血浆炎症蛋白质组谱识别超重或肥胖儿童中的MASLDDOI: 10.1186/s12933-025-03011-0
Frontiers in nutrition IF: 05.100Volume 12, Issue No.80Different association between triglyceride-glucose index and mild cognitive impairment in type 2 diabetes mellitus patients with and without diabetic kidney disease甘油三酯-葡萄糖指数与2型糖尿病患者轻度认知障碍的不同关联：有无糖尿病肾病的比较DOI: 10.3389/fnut.2025.1681164
Journal of diabetes research IF: 03.400Volume 2025, Issue No.81TangNaikang Formula Alleviates Podocyte Injury in Diabetic Nephropathy by Modulating the SHIP2/PI3K/AKT PathwayTangNaikang方通过调节SHIP2/PI3K/AKT通路缓解糖尿病肾病中的足细胞损伤DOI: 10.1155/jdr/6568591
BMC endocrine disorders IF: 03.300Volume 25, Issue 1No.82High serum isthmin-1 as a biomarker for the progression of renal function decline in patients with type 2 diabetes mellitus高血清isthmin-1作为2型糖尿病患者肾功能下降进展的生物标志物DOI: 10.1186/s12902-025-02093-x
J Clin Biochem Nutr IF: 01.700Volume 77, Issue 3No.83Loganic acid ameliorates diabetic cardiomyopathy via suppressing TLR4/p38 MAPK signaling-mediated oxidative stress and inflammation马钱子酸通过抑制TLR4/p38 MAPK信号介导的氧化应激和炎症改善糖尿病心肌病DOI: 10.3164/jcbn.25-91
Frontiers in nutrition IF: 05.100Volume 12, Issue No.84Atherosclerosis index and BMI: new predictors of cognitive function in ischemic survivors动脉粥样硬化指数与BMI：缺血性中风幸存者认知功能的新预测因子DOI: 10.3389/fnut.2025.1703425
BMC endocrine disorders IF: 03.300Ahead of Print.No.85Metabolically healthy obesity increases the risks of MASLD and hyperuricemia: a cohort study with mediation analysis代谢健康型肥胖增加MASLD和高尿酸血症风险：一项包含中介分析的队列研究DOI: 10.1186/s12902-025-02106-9
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Obesity surgery IF: 03.100Ahead of Print.No.37Development and External Validation of a Machine Learning-Based Risk Score for Stent Outcomes in Post-Bariatric Leak Management: The "Alexandria-Bari-Stent" Tool开发并外部验证一种基于机器学习的风险评分工具用于减肥手术后泄漏管理中支架结局：'Alexandria-Bari-Stent'工具DOI: 10.1007/s11695-025-08321-6
Diabetologia IF: 10.200Ahead of Print.No.38Ketone supplementation dose-dependently lowers postprandial blood glucose, lipid and ghrelin levels in individuals with type 2 diabetes: a randomised crossover study酮补充剂量依赖性地降低2型糖尿病患者餐后血糖、血脂和胃饥饿素水平：一项随机交叉研究DOI: 10.1007/s00125-025-06614-0
BMJ open IF: 02.300Volume 15, Issue 11No.39Is Cardiovascular Mortality Among People with Epilepsy increasing? A retrospective US population study癫痫患者的心血管死亡率在上升吗？一项回顾性美国人口研究DOI: 10.1136/bmjopen-2024-095195
Clin J Am Soc Nephrol IF: 07.100Ahead of Print.No.40Impact of Empagliflozin on Glomerular Hyperfiltration and Albuminuria in Youth with Type 2 Diabetes: Post-Hoc Analysis of DINAMO恩格列净对青少年2型糖尿病患者肾小球高滤过和白蛋白尿的影响：DINAMO研究的事后分析DOI: 10.2215/CJN.0000000889
Eur J Clin Nutr IF: 03.300Ahead of Print.No.41Iron status in women of reproductive age in Switzerland: the role of inflammation and ferritin thresholds for the prevalence of iron deficiency-a cross-sectional study瑞士育龄女性铁状态：炎症作用和铁蛋白阈值对缺铁患病率的影响——一项横断面研究DOI: 10.1038/s41430-025-01685-z
International journal of obesity IF: 03.800Ahead of Print.No.42The association between antibiotic use in infancy and overweight during childhood and adolescence: a historical cohort study婴儿期抗生素使用与儿童和青少年超重的关联：一项历史队列研究DOI: 10.1038/s41366-025-01972-6
International journal of obesity IF: 03.800Ahead of Print.No.43Post-intervention sustainability of time-restricted eating versus caloric restriction: a secondary analysis限时进食与热量限制干预后可持续性比较：一项次要分析DOI: 10.1038/s41366-025-01968-2
Scientific reports IF: 03.900Volume 15, Issue 1No.44Examining the interplay between sdLDL, resistin, and BMI探讨sdLDL、抵抗素与BMI之间的相互作用DOI: 10.1038/s41598-025-26772-w
Annals of surgical oncology IF: 03.500Ahead of Print.No.45Waist-to-Height Ratio as a Predictor Complementary to BMI for Postoperative Pancreatic Fistula After Pancreatoduodenectomy for Periampullary Tumors腰高比作为BMI的补充预测因子用于壶腹周围肿瘤胰十二指肠切除术后胰腺瘘DOI: 10.1245/s10434-025-18575-0
Microbial ecology IF: 04.000Ahead of Print.No.46Bioactive Plasmid- and Phage-Encoded Antimicrobial Peptides (AMPs) in the Human Gut: A Metatranscriptome-Virome Profiling Reveals Exploratory Links to Metabolic Human Diseases人类肠道中质粒和噬菌体编码的生物活性抗菌肽（AMPs）：宏转录组-病毒组分析揭示与代谢性人类疾病的探索性关联DOI: 10.1007/s00248-025-02620-2
Scand J Psychol IF: 02.100Ahead of Print.No.47Directionality of Self-Regulation and Self-Efficacy Within a Treatment Targeting Cardiovascular Exercise and Emotional Eating in Women: Interpretation and Application of Behavioral Theory女性中心血管运动和情绪化饮食治疗中的自我调节与自我效能方向性：行为理论的解读与应用DOI: 10.1111/sjop.70057
Journal of women's health IF: 01.900Ahead of Print.No.48Prevalence of Clinical Obesity Based on Updated Definitions among Women by Sexual Identity: Results from 2001 to 2016 National Health and Nutrition Examination Survey基于更新定义的女性临床肥胖患病率与性身份的关系：2001年至2016年国家健康与营养检查调查结果DOI: 10.1177/15409996251401467
J Laparoendosc Adv Surg Tech A IF: 01.100Ahead of Print.No.49Evaluating Bariatric Surgery in Patients Aged 60 Years and Older: A Retrospective Multicenter Comparison of Sleeve Gastrectomy and Roux-en-Y Gastric Bypass评估60岁及以上患者减重手术：袖状胃切除术与Roux-en-Y胃旁路术的回顾性多中心比较DOI: 10.1177/10926429251401463
Endocrinol Diabetes Nutr (Engl Ed) IF: 01.800Ahead of Print.No.50Continuity of care in obesity clinical care肥胖临床护理的连续性DOI: 10.1016/j.endien.2025.501658
Curr Probl Pediatr Adolesc Health Care IF: 03.700Ahead of Print.No.51The learning curve of a pediatric bariatric surgery program: Lessons learned from the first 100 patients儿科减重手术项目的学习曲线：从100名患者中学习的教训DOI: 10.1016/j.cppeds.2025.101888
BMJ open IF: 02.300Volume 15, Issue 11No.52The Health Survey of São Paulo - ISA-Physical Activity and Environment Longitudinal Study圣保罗健康调查 - ISA-体力活动与环境纵向研究DOI: 10.1136/bmjopen-2025-107842
BMJ open respiratory research IF: 03.400Volume 12, Issue 1No.53Rheumatoid arthritis and risk of non-tuberculous mycobacterial pulmonary disease: a nationwide longitudinal cohort study类风湿关节炎与非结核分枝杆菌肺病风险：一项全国性纵向队列研究DOI: 10.1136/bmjresp-2025-003397
Korean Journal of Radiology IF: 05.300Volume 26, Issue 12No.54Effects of Computed Tomography Technical Parameters on Body-Composition Analysis计算断层扫描技术参数对身体成分分析的影响DOI: 10.3348/kjr.2025.1140
Physiology & behavior IF: 02.500Ahead of Print.No.55Emotional eating and metabolic dysfunction-associated steatotic liver disease (MASLD): a pre-registered study in a clinical population情绪性饮食与代谢功能障碍相关脂肪性肝病 (MASLD)：一项临床人群的预注册研究DOI: 10.1016/j.physbeh.2025.115186
Die Rehabilitation IF: 02.300Ahead of Print.No.56[Potential and challenges of an outpatient rehabilitation programme for children and adolescents with obesity - Interviews with professionals from rehabilitation centres]肥胖儿童和青少年门诊康复计划的潜力与挑战——康复中心专业人员的访谈DOI: 10.1055/a-2724-3558
Journal of nutrition IF: 03.800Ahead of Print.No.57Plant-based diet as a precursor to human gut diversity植物性饮食作为人类肠道多样性的先导DOI: 10.1016/j.tjnut.2025.11.020
J Clin Endocrinol Metab IF: 05.100Ahead of Print.No.58Approach to the Patient: Clinical Outcomes and Interim Strategies Following Discontinuation of Incretin Agonists患者管理方法：停用肠促胰岛素激动剂后的临床结局与过渡策略DOI: 10.1210/clinem/dgaf641
Georgian Medical NewsVolume 2025, Issue 366No.59HEALTH-RELATED QUALITY OF LIFE OF POST-COVID-19 PATIENTS IN KAZAKHSTAN哈萨克斯坦COVID-19后遗症患者健康相关生活质量研究https://pubmed.ncbi.nlm.nih.gov/41314198
Clin Neurol Neurosurg IF: 01.600Ahead of Print.No.60Factors associated with venous thromboembolism in hospitalized traumatic brain injury patients with external ventricular drains: Retrospective cohort study住院创伤性脑损伤患者使用外脑室引流时静脉血栓栓塞的相关因素：回顾性队列研究DOI: 10.1016/j.clineuro.2025.109265
Women and birth IF: 04.100Ahead of Print.No.61"Running in circles": Breastfeeding experiences in women who have had bariatric surgery before pregnancy: A qualitative study"原地打转"：怀孕前接受减重手术的女性母乳喂养经历的定性研究DOI: 10.1016/j.wombi.2025.102146
J Nutr Health Aging IF: 04.000Ahead of Print.No.62Associations of Individual Beverage Types and Substitution with Dementia Risk: A UK Biobank Cohort Study个体饮料类型与替代与痴呆风险的关联：一项英国生物样本库队列研究DOI: 10.1016/j.jnha.2025.100740
Drug and alcohol dependence IF: 03.600Ahead of Print.No.63Optimizing measures of drinking to predict alcohol-related consequences优化饮酒测量以预测酒精相关后果DOI: 10.1016/j.drugalcdep.2025.112973
Public health IF: 03.200Ahead of Print.No.64Protective predictors of cardiovascular disease: an explainable AI approach心血管疾病的保护性预测因素：可解释人工智能方法DOI: 10.1016/j.puhe.2025.106050
Georgian Medical NewsVolume 2025, Issue 366No.65THE INCIDENCE OF URINARY TRACT INFECTION AMONG PATIENTS TREATED WITH VARIABLE DOSES OF DAPAGLIFLOZIN: A COMPARATIVE STUDY不同剂量达格列净治疗患者尿路感染发生率比较研究https://pubmed.ncbi.nlm.nih.gov/41314192
Nature communications IF: 15.700Volume 16, Issue 1No.66Inflammation impairs post-hospital discharge growth among children hospitalised with acute illness in sub-Saharan Africa and south Asia炎症损害撒哈拉以南非洲和南亚急性疾病住院儿童出院后的生长DOI: 10.1038/s41467-025-66245-2
Scientific reports IF: 03.900Volume 15, Issue 1No.67Insulin resistance in polycystic ovary syndrome phenotypes and the vicious cycle model in its etiology多囊卵巢综合征表型中的胰岛素抵抗及其病因学中的恶性循环模型DOI: 10.1038/s41598-025-26718-2
Nature communications IF: 15.700Volume 16, Issue 1No.68Plasma lipopolysaccharide levels predict mortality in acutely ill children in Low- and Middle-Income Countries血浆脂多糖水平预测低收入和中等收入国家急病儿童的死亡率DOI: 10.1038/s41467-025-65429-0
Nature immunology IF: 27.600Ahead of Print.No.69A microenvironment-driven HLA-II-associated insulin neoantigen elicits persistent memory T cell activation in diabetes微环境驱动的HLA-II相关胰岛素新抗原引发糖尿病中持续性记忆T细胞激活DOI: 10.1038/s41590-025-02343-z
Contact dermatitis IF: 04.600Ahead of Print.No.70Results of GC-MS Analyses of 40 Extracts of Diabetes Devices40种糖尿病设备提取物的GC-MS分析结果DOI: 10.1111/cod.70052
Endocrinol Diabetes Nutr (Engl Ed) IF: 01.800Ahead of Print.No.71Polymorphisms in TLR4 and IL6 and their association with obesity and insulin resistance in a Venezuelan populationTLR4和IL6基因多态性与委内瑞拉人群肥胖和胰岛素抵抗的关联DOI: 10.1016/j.endien.2025.501657
Clinical nutrition ESPEN IF: 02.600Ahead of Print.No.72Suppressive Effect of Myristic Acid on Postprandial Blood Glucose Elevation in Healthy Adults with High Blood Glucose Levels: A Double-blinded, Randomized, Placebo-controlled, Parallel-group Study肉豆蔻酸对高血糖健康成人餐后血糖升高的抑制作用：一项双盲、随机、安慰剂对照、平行组研究DOI: 10.1016/j.clnesp.2025.11.148
Contemporary clinical trials IF: 01.900Ahead of Print.No.73Effects of daily low oxygen exposure on weight status, body composition, and metabolic health in adults with obesity: Protocol for a randomized, double-blind, controlled-feeding study每日低氧暴露对肥胖成年人体重状态、身体成分和代谢健康的影响：一项随机、双盲、控制喂养研究方案DOI: 10.1016/j.cct.2025.108167
J Nutr Biochem IF: 04.900Ahead of Print.No.74Olive-derived elenolic acid surpasses metformin and rivals liraglutide in managing blood glucose and obesity in mouse models of type 2 diabetes橄榄来源的elenolic acid在管理2型糖尿病小鼠模型中的血糖和肥胖方面超越metformin并媲美利拉鲁肽DOI: 10.1016/j.jnutbio.2025.110206
Neuroscience IF: 02.800Ahead of Print.No.75The interface between the homeostatic and hedonic energy balance circuitries in the regulation of appetitive behavior: A focus on steroidogenic factor-1/pituitary adenylate cyclase-activating polypeptide neurons in the hypothalamic ventromedial nucleus稳态和享乐性能量平衡回路在食欲行为调节中的界面：聚焦于下丘脑腹内侧核中的类固醇生成因子-1/垂体腺苷酸环化酶激活多肽神经元DOI: 10.1016/j.neuroscience.2025.11.038
Diabetes Res Clin Pract IF: 07.400Ahead of Print.No.76Chat, Gemini and Claude at the dinner table: assessing general-purpose AI tools for carbohydrate counting in the context of type 1 diabetes餐桌上的Chat、Gemini和Claude：评估通用AI工具在1型糖尿病碳水化合物计数中的应用DOI: 10.1016/j.diabres.2025.113031
Gynecol Obstet Fertil Senol IF: 00.600Ahead of Print.No.77[Benefits and risks of antenatal corticosteroids]产前皮质类固醇的益处与风险DOI: 10.1016/j.gofs.2025.11.005
Experimental Eye Research IF: 02.700Ahead of Print.No.78Regenerative Effects of Topical Insulin on Corneal Wound Healing: From Surface Restoration to Stromal Remodeling局部胰岛素对角膜伤口愈合的再生效应：从表面修复到基质重塑DOI: 10.1016/j.exer.2025.110775
Journal of controlled release IF: 11.500Ahead of Print.No.79Oral gene delivery platform based on glycol chitosan-PEG-lactoferrin conjugate基于乙二醇壳聚糖-PEG-乳铁蛋白偶联物的口服基因递送平台DOI: 10.1016/j.jconrel.2025.114463
Georgian Medical NewsVolume 2025, Issue 366No.80THE INCIDENCE OF URINARY TRACT INFECTION AMONG PATIENTS TREATED WITH VARIABLE DOSES OF DAPAGLIFLOZIN: A COMPARATIVE STUDY使用变量剂量的达格列净治疗患者中尿路感染的发生率：一项比较研究https://pubmed.ncbi.nlm.nih.gov/41314192
Diabetes & metabolic syndrome IF: 03.400Ahead of Print.No.81Experience with insulin detemir for type 2 diabetes in older people and people with comorbidities胰岛素detemir在老年人和合并症患者中治疗2型糖尿病的经验DOI: 10.1016/j.dsx.2025.103327
Biomedicine & pharmacotherapy IF: 07.500Ahead of Print.No.82Therapeutic prospects of modulating TLR4/MAPK/ROS signalling in obesity-associated neuroinflammation调节TLR4/MAPK/ROS信号在肥胖相关神经炎症中的治疗前景DOI: 10.1016/j.biopha.2025.118805
Experimental Eye Research IF: 02.700Ahead of Print.No.83Small extracellular vesicles derived from human retinal pericytes under high glucose and hypoxia conditions promote endothelial cell dysfunction in vitro高葡萄糖和缺氧条件下人视网膜周细胞来源的小细胞囊泡在体外促进内皮细胞功能障碍DOI: 10.1016/j.exer.2025.110768
J Diabetes Complications IF: 03.100Ahead of Print.No.84Dipeptidyl peptidase-4 inhibitors and diabetic retinopathy in type 2 diabetes: A network meta-analysis of randomized clinical trials二肽基肽酶-4抑制剂与2型糖尿病视网膜病变：一项随机临床试验的网络荟萃分析DOI: 10.1016/j.jdiacomp.2025.109234
International Heart Journal IF: 01.300Volume 66, Issue 6, Page 925-1037No.85Association between Cardiovascular-Kidney-Metabolic Syndrome and Relative Muscle Loss in American Adults心血管-肾脏-代谢综合征与美国成年人相对肌肉损失的关联DOI: 10.1536/ihj.25-117
International Heart Journal IF: 01.300Volume 66, Issue 6, Page 925-1037No.86The Association Between Body Mass Index and In-hospital Mortality in Patients with Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention体重指数与接受经皮冠状动脉介入治疗的急性心肌梗死患者院内死亡率的关联DOI: 10.1536/ihj.25-135
Eur J Obstet Gynecol Reprod Biol IF: 01.900Ahead of Print.No.87Preterm labour induction: modalities, implications and outcomes早产引产：方式、影响与结局DOI: 10.1016/j.ejogrb.2025.114847
J Foot Ankle Res IF: 02.200Volume 18, Issue 4No.88A Cross-Sectional Study Exploring the Suitability of Skin Hydration Measurement Devices for Use on the Foot一项横断面研究探索皮肤水合测量设备在足部使用的适宜性DOI: 10.1002/jfa2.70104
Hormone research in p?diatrics : IF: 02.700Ahead of Print.No.89The EndoCompass Supplement: Preface, Acknowledgments, and DeclarationsEndoCompass 增刊：前言、致谢与声明DOI: 10.1159/000549150
Diabetes Technol Ther IF: 06.300Ahead of Print.No.90Arterialization of Venous Blood May Affect the Time Lag of Continuous Glucose Sensors静脉血动脉化可能影响连续葡萄糖传感器的时间延迟DOI: 10.1177/15209156251403566
J Vet Emerg Crit Care (San Antonio) IF: 01.200Ahead of Print.No.91Iatrogenic Pneumothorax in a Cat Following Placement of a Continuous Glucose Sensor猫放置连续血糖传感器后发生医源性气胸DOI: 10.1111/vec.70065
Journal of Vascular Research IF: 02.300Ahead of Print.No.92Assessing Sex Differences in Metabolic Disease on Vasculopathy Using the Vascular Health Index使用血管健康指数评估代谢疾病对血管病变的性别差异DOI: 10.1159/000549739
Advanced science IF: 14.100Ahead of Print.No.93Label-Free Leukocyte Biophysical Profiling Using Impedance-Deformability Cytometry for Rapid Cardiovascular Risk Stratification基于阻抗-变形性细胞术的无标记白细胞生物物理特征分析用于快速心血管风险分层DOI: 10.1002/advs.202516021
PACE IF: 01.300Ahead of Print.No.94Predictors of Atrial High-Rate Episodes and Inappropriate Device Therapy in Implantable Cardioverter Defibrillators植入式心律转复除颤器中房性高频率事件与不适当设备治疗的预测因子DOI: 10.1111/pace.70094
Physical biology IF: 01.600Ahead of Print.No.95Network modeling and analysis of MAP Kinase pathway to assess role of genes in tumor developmentMAP激酶通路的网络建模与分析以评估基因在肿瘤发展中的作用DOI: 10.1088/1478-3975/ae25af
Science advances IF: 12.500Volume 11, Issue 48No.96Metabolic reprogramming in Fanconi anemia: Evidence of compromised glucose oxidation, enhanced ketogenesis, and metabolic inflexibility范可尼贫血中的代谢重编程：葡萄糖氧化受损、酮体生成增强和代谢不灵活性的证据DOI: 10.1126/sciadv.ady6117
Eur J Obstet Gynecol Reprod Biol IF: 01.900Ahead of Print.No.97Impact of semaglutide exposure on fetal and neonatal outcomes in pregnant women: a systematic review司美格鲁肽暴露对孕妇胎儿和新生儿结局的影响：一项系统评价DOI: 10.1016/j.ejogrb.2025.114836
Current obesity reports IF: 11.000Volume 14, Issue 1No.98Mood Disorders, Metabolic Bariatric Surgery, and Weight Loss Pharmacotherapy: a Research Update情绪障碍、代谢减重手术和减重药物疗法：研究更新DOI: 10.1007/s13679-025-00674-4
Obesity surgery IF: 03.100Ahead of Print.No.99Prevalence and Predictors of Hepatic Steatosis in Patients Undergoing Sleeve Gastrectomy: A Biopsy-proven Study接受袖状胃切除术患者肝脂肪变性的患病率及预测因素：一项活检证实的研究DOI: 10.1007/s11695-025-08386-3
Pediatric Cardiology IF: 01.400Ahead of Print.No.100Physician Preparedness for Managing Juvenile Obesity in the MENA Region: A Cross-Sectional Analysis of Perceptions, Knowledge, Practices, and Barriers中东和北非地区医生管理青少年肥胖的准备度：一项关于认知、知识、实践和障碍的横断面分析DOI: 10.1007/s00246-025-04121-y
Nutrición hospitalaria IF: 01.100Ahead of Print.No.101Comparative impact of vitamin D intake on childhood obesity in Qatar - A retrospective analysis study维生素D摄入对卡塔尔儿童肥胖影响的比较——一项回顾性分析研究DOI: 10.20960/nh.06072
Nutrición hospitalaria IF: 01.100Ahead of Print.No.102Sensitivity of body mass index as a current criterion of nutrition: new body mass index redefinition for young adults身体质量指数作为营养评估标准的敏感性：针对年轻成年人的新BMI定义DOI: 10.20960/nh.05473
J Pediatric Infect Dis Soc IF: 02.600Ahead of Print.No.103Weight Gain Among Children and Adolescents on Dolutegravir in Spain西班牙儿童和青少年使用多替拉韦后的体重增加DOI: 10.1093/jpids/piaf110
Arch Endocrinol Metab IF: 02.300Volume 70, Issue special 1No.104Addressing weight stigma and communicating with patients应对体重污名并改善与患者沟通DOI: 10.20945/2359-4292-2025-0335
L?knablaeie IF: 00.600Volume 111, Issue 12No.105[New recommedations in the treatment of restless legs syndrome - dopaminergic drugs on the way out]不宁腿综合征治疗新推荐——多巴胺能药物退场DOI: 10.17992/lbl.2025.12.868
Probiotics Antimicrob Proteins IF: 04.400Ahead of Print.No.106Gut Microbiome in Obesity: A Narrative Review of Mechanisms, Interventions, and Future Directions肠道微生物组在肥胖中的作用：机制、干预和未来方向的叙述性综述DOI: 10.1007/s12602-025-10855-1
Int J Clin Pharm IF: 03.200Ahead of Print.No.107Pharmacist input to depression screening and management in patients with diabetes: a systematic review药师在糖尿病患者抑郁症筛查和管理中的参与：一项系统评价DOI: 10.1007/s11096-025-02056-1
Advances in therapy IF: 04.000Ahead of Print.No.108Correction to: Epidemiology Landscape and Impact of Overweight and Obesity in Adults: Multi-country Results from the IMPACT-O Study更正：成人超重和肥胖的流行病学格局与影响：来自IMPACT-O研究的多国结果DOI: 10.1007/s12325-025-03446-7
Molecular biology reports IF: 02.800Volume 53, Issue 1No.109Policosanol ameliorates testicular injury and improves steroidogenesis in diabetic hypercholesterolemic ratsPolicosanol 改善糖尿病高胆固醇血症大鼠的睾丸损伤并促进类固醇生成DOI: 10.1007/s11033-025-11241-4
Obesity surgery IF: 03.100Ahead of Print.No.110The Effect of Increased Sodium Intake with a Carbohydrate-Rich Meal on Glucose Homeostasis in People without Diabetes after Roux-en-Y Gastric Bypass: a Proof-of-Concept, Randomized, Open-Label, Crossover Study增加钠摄入对无糖尿病Roux-en-Y胃旁路术后患者碳水化合物丰富餐后葡萄糖稳态的影响：一项概念验证、随机、开放标签、交叉研究DOI: 10.1007/s11695-025-08420-4
Diabetes therapy IF: 02.600Ahead of Print.No.111Correction to: Quantifying Patient Preferences for Basal Insulin Treatments in Adults Living with Type 2 Diabetes: A Discrete Choice Experiment in Canada, Spain, France, and Japan量化成年2型糖尿病患者对基础胰岛素治疗的偏好：在加拿大、西班牙、法国和日本的离散选择实验DOI: 10.1007/s13300-025-01820-w
Diabetes therapy IF: 02.600Ahead of Print.No.112Cost-effectiveness of Freestyle Libre Systems for People with Type 2 Diabetes Mellitus on Basal Insulin Therapy in the Netherlands: An Economic Evaluation from a Societal Perspective Within a Publicly Funded Healthcare SystemFreestyle Libre系统在荷兰用于基础胰岛素治疗的2型糖尿病患者的成本效益：基于公共资助医疗体系社会视角的经济评估DOI: 10.1007/s13300-025-01821-9
Histochemistry and cell biology IF: 02.100Volume 163, Issue 1No.113Enhanced skin regeneration in diabetic wounds using collagen-hyaluronic acid scaffold incorporated with epigallocatechin gallate: a multifactorial healing approach胶原-透明质酸支架结合EGCG增强糖尿病伤口皮肤再生的多因素愈合策略DOI: 10.1007/s00418-025-02439-5
Clinical oral investigations IF: 03.100Volume 29, Issue 12No.114Comparison of growth factor concentrations in platelet-rich fibrin biomaterial in different systemic diseases比较不同系统性疾病中富血小板纤维蛋白生物材料中生长因子的浓度DOI: 10.1007/s00784-025-06673-y
Basic Research in Cardiology IF: 08.000Ahead of Print.No.115Serum amyloid A in HFpEF and cardiometabolic diseases血清淀粉样蛋白A在HFpEF和心脏代谢疾病中的作用DOI: 10.1007/s00395-025-01150-9
Nutrición hospitalaria IF: 01.100Ahead of Print.No.116Anxiety in medical students: its relationship with the consumption of unhealthy foods, obesity, and the risk of cardiometabolic diseases医学生焦虑：与不健康食物消费、肥胖及心脏代谢疾病风险的关系DOI: 10.20960/nh.05689
Nutrición hospitalaria IF: 01.100Ahead of Print.No.117Predictive value of novel inflammatory markers for mortality in patients with chronic kidney disease ‒ Evidence from NHANES 1999-2018新型炎症标志物对慢性肾脏病患者死亡率的预测价值——基于NHANES 1999-2018的证据DOI: 10.20960/nh.05709
Expert Rev Clin Pharmacol IF: 03.000Ahead of Print.No.118Clinical pharmacokinetics on canagliflozin: a systematic review of in-vitro and in-vivo studies卡格列净的临床药代动力学：体外和体内研究的系统评价DOI: 10.1080/17512433.2025.2597512
J Magn Reson Imaging IF: 03.500Ahead of Print.No.119Prospective Comparison of DWI-Derived Virtual MR Elastography and Conventional MR Elastography in Metabolic Dysfunction-Associated Steatotic Liver Disease and Healthy Volunteers在代谢功能障碍相关脂肪性肝病和健康志愿者中DWI衍生的虚拟MR弹性成像与常规MR弹性成像的前瞻性比较DOI: 10.1002/jmri.70192
Arch Endocrinol Metab IF: 02.300Volume 70, Issue special 1No.120Autonomic neuropathy in diabetes糖尿病自主神经病变DOI: 10.20945/2359-4292-2025-0406
Arch Endocrinol Metab IF: 02.300Volume 70, Issue special 1No.121Hypercoagulability in Cushing's syndrome: past, present, future库欣综合征中的高凝状态：过去、现在、未来DOI: 10.20945/2359-4292-2025-0095
Arch Endocrinol Metab IF: 02.300Volume 70, Issue special 1No.122Clinical dermatoendocrinology: saving lives by looking at the skin临床皮肤内分泌学：通过观察皮肤挽救生命DOI: 10.20945/2359-4292-2025-0062
JMIR diabetes IF: 02.600Volume 10, Issue No.123Toward a Personalized Basal Tuner for Detecting Basal Rate Inaccuracies in Type 1 Diabetes Mellitus Without Meal Data: Algorithm Development and Retrospective Validation Study迈向无需餐食数据的1型糖尿病基础率不准确性检测的个性化基础率调谐器：算法开发与回顾性验证研究DOI: 10.2196/72769
J Am Geriatr Soc IF: 04.500Ahead of Print.No.124Predictors of a Gabapentinoid-Loop-Diuretic Prescribing Cascade in U.S. Nursing Home Residents美国养老院居民中加巴喷丁-袢利尿剂处方级联的预测因素DOI: 10.1111/jgs.70219
JMIR formative research IF: 02.100Volume 9, Issue No.125Developing eHealth Interventions to Improve Diabetes Management in Emerging Adulthood: Qualitative Formative Study开发电子健康干预措施以改善新兴成年期糖尿病管理：定性形成性研究DOI: 10.2196/75623
Transfusion IF: 02.000Ahead of Print.No.126Hemoglobin A1c levels do not affect vasovagal risk in blood donors血红蛋白A1c水平不影响献血者血管迷走性反应风险DOI: 10.1111/trf.70012
Medicina IF: 00.600Volume 85, Issue 6No.127[Mild autonomic cortisol secretion: comorbidities and surgical treatment outcomes]轻度自主性皮质醇分泌：合并症与手术治疗结局https://pubmed.ncbi.nlm.nih.gov/41313106
ANZ journal of surgery IF: 01.600Ahead of Print.No.128Melioidosis Aortic Aneurysms, 2019-2025: Incidence, Management and Outcomes From a Regional Tertiary Centre in North Queensland类鼻疽主动脉瘤，2019-2025：来自北昆士兰地区三级中心的发病率、管理和结局DOI: 10.1111/ans.70400
Acta médica portuguesa IF: 01.000Ahead of Print.No.129Immune Checkpoint Inhibitor-Induced Thyroidal, Pancreatic, and Pituitary Dysfunction: Diagnostic Challenges in a Cancer Patient免疫检查点抑制剂诱导的甲状腺、胰腺和垂体功能障碍：癌症患者的诊断挑战DOI: 10.20344/amp.23752
Arch Endocrinol Metab IF: 02.300Volume 70, Issue special 1No.130Cardio-kidney-metabolic (CKM) framework: A nephrologist's perspective心肾代谢（CKM）框架：肾脏病学家的视角DOI: 10.20945/2359-4292-2025-0405
Arch Endocrinol Metab IF: 02.300Volume 70, Issue special 1No.131Subclinical primary aldosteronism亚临床原发性醛固酮增多症DOI: 10.20945/2359-4292-2025-0400
Archiv der Pharmazie IF: 03.600Volume 358, Issue 11No.132Synthesis of Promising Biguanide Derivatives Bearing Urea/Thiourea as Type II Antidiabetic Agents合成含有尿素/硫脲的潜力双胍衍生物作为II型抗糖尿病药物DOI: 10.1002/ardp.70150
Mol Nutr Food Res IF: 04.200Ahead of Print.No.133Synbiotic Nutraceutical Mitigates Gestational Diabetes Effects and Cardiovascular Dysfunction in Rat Offspring合生元营养补充剂减轻大鼠后代的妊娠期糖尿病效应和心血管功能障碍DOI: 10.1002/mnfr.70340
Obesity surgery IF: 03.100Ahead of Print.No.134Effects of Semaglutide and Tirzepatide on Recurrent Weight Gain After Bariatric Surgery: A Systematic Review and Meta-analysis司美格鲁肽和替尔泊肽对减重手术后复发性体重增加的影响：一项系统综述和荟萃分析DOI: 10.1007/s11695-025-08414-2
Nephrol Dial Transplant IF: 05.600Ahead of Print.No.135A Consensus Statement on the management of Vertebral Fractures in CKD stages G4-G5D关于CKD G4-G5D期椎体骨折管理的共识声明DOI: 10.1093/ndt/gfaf256
Physiological reports IF: 01.900Volume 13, Issue 23No.136The effect of a ketone monoester drink on blood glucose and substrate oxidation in adults with metabolic syndrome and matched controls酮酯单酯饮料对代谢综合征成人和匹配对照组血糖及底物氧化的影响DOI: 10.14814/phy2.70676
Journal of medical case reports IF: 00.900Volume 19, Issue 1No.137Carbuncle management: skin-sparing saucerization followed by delayed primary closure is a new treatment modality: a case series痈管理：保留皮肤的碟形切除术后延迟一期闭合是一种新的治疗方式：一个病例系列DOI: 10.1186/s13256-025-05309-9
BMC ophthalmology IF: 01.700Ahead of Print.No.138Prevalence of retinopathy of prematurity in African preterm infants and evaluation of the accuracy of the WINROP predictive algorithm: an observational clinical study非洲早产儿早产儿视网膜病变的患病率及WINROP预测算法准确性的评估：一项观察性临床研究DOI: 10.1186/s12886-025-04527-5
Ophthalmology science IF: 04.600Volume 6, Issue 1No.139Macrophage-Like Cell Density and Distribution in Relation to Vascular Leakage in Diabetes巨噬细胞样细胞密度和分布与糖尿病血管渗漏的关系DOI: 10.1016/j.xops.2025.100955
Journal of hematology & oncology IF: 40.400Volume 18, Issue 1No.140The gynecologic tumor risk related to GLP-1 receptor agonists and SGLT2 inhibitors use: a network meta-analysis of 91 randomized controlled trialsGLP-1受体激动剂和SGLT2抑制剂使用与妇科肿瘤风险：一项基于91项随机对照试验的网络荟萃分析DOI: 10.1186/s13045-025-01750-x
Journal of diabetes IF: 03.700Volume 17, Issue 12No.141Advancing Diabetic Foot Ulcer Care: Focus on the Post-Healing Transition Phase推进糖尿病足溃疡护理：关注愈合后过渡阶段DOI: 10.1111/1753-0407.70173
Canadian liver journal IF: 01.200Volume 8, Issue 3No.142Evaluation of a novel albumin platelet product (APP) fibrosis index and three non-invasive fibrosis indices in metabolic dysfunction-associated steatotic liver disease评估新型白蛋白血小板产物（APP）纤维化指数和三种无创纤维化指数在代谢功能障碍相关脂肪性肝病中的表现DOI: 10.3138/canlivj-2025-0017
SAGE open medicine IF: 02.100Volume 13, Issue No.143Corrigendum to "Glycemic management in patients with immune-related diabetes mellitus: A scoping review"勘误：'免疫相关糖尿病患者的血糖管理：范围综述'DOI: 10.1177/20503121251378700
Plast Reconstr Surg Glob Open IF: 01.800Volume 13, Issue 11No.144A Retrospective Application of Deep Sternal Wound Dehiscence and Malunion Risk Scores on Sternal Nonunion Patients胸骨不愈合患者中胸骨深部伤口裂开和错位风险评分的回顾性应用DOI: 10.1097/GOX.0000000000007281
Transplant international IF: 03.000Volume 38, Issue No.145The Variation in Practice of the Living Donor Kidney Transplant Pathway in the UK: Results of a National Survey英国活体供肾移植路径实践的变化：全国调查结果DOI: 10.3389/ti.2025.15341
Geriatr Orthop Surg Rehabil IF: 01.600Volume 16, Issue No.146Evaluating Barriers to Achieving the Minimal Important Change in Older Patients With Hip Fractures After Post-Acute Care评估老年髋部骨折患者在急性期后护理后达到最小重要变化的障碍DOI: 10.1177/21514593251403425
J Clin Transl Endocrinol IF: 03.300Volume 42, Issue No.147Alternative approaches to glucose measurements during oral glucose tolerance testing in youth with cystic fibrosis: a mixed methods pilot study囊性纤维化青少年口服葡萄糖耐量试验中葡萄糖测量的替代方法：一项混合方法试点研究DOI: 10.1016/j.jcte.2025.100421
Curēus IF: 01.300Volume 17, Issue 11No.148Post-COVID-19 Barriers to Diabetic Retinopathy Screening Attendance: An Updated Systematic Review后COVID-19时代糖尿病视网膜病变筛查出勤的障碍：一项更新的系统性回顾DOI: 10.7759/cureus.96550
Frontiers in pharmacology IF: 04.800Volume 16, Issue No.149A comprehensive review on diabetic foot ulcer addressing vascular insufficiency, impaired immune response, and delayed wound healing mechanisms糖尿病足溃疡的综合综述：探讨血管功能不全、免疫反应受损和伤口愈合延迟机制DOI: 10.3389/fphar.2025.1622055
Frontiers in pharmacology IF: 04.800Volume 16, Issue No.150Diabetes and traditional remedies in Medieval Persia: a historical perspective中世纪波斯的糖尿病与传统疗法：历史视角DOI: 10.3389/fphar.2025.1673440
Curēus IF: 01.300Volume 17, Issue 10No.151Ten-Year Follow-Up of Visual Outcomes After Vitrectomy for Clinically Non-Tractional Diabetic Macular Edema玻璃体切除术用于临床非牵拉性糖尿病黄斑水肿后视力结果的十年随访DOI: 10.7759/cureus.95537
Curēus IF: 01.300Volume 17, Issue 10No.152A Hypercalcemic Deception: Uncovering an Unusual Case of Familial Hypocalciuric Hypercalcemia高钙血症的欺骗：揭示一个不寻常的家族性低尿钙高钙血症病例DOI: 10.7759/cureus.95514
Curēus IF: 01.300Volume 17, Issue 10No.153Improving Diabetic Foot Care Through a Multidisciplinary Clinic: Experience From Pilgrim Hospital, UK通过多学科诊所改善糖尿病足部护理：来自英国Pilgrim医院的经验DOI: 10.7759/cureus.95480
Orthop J Sports Med IF: 02.500Volume 13, Issue 11No.154Factors Affecting Late-Period Retear That Occurs More than 2 Years After Rotator Cuff Repair影响肩袖修复后2年以上晚期再撕裂的因素DOI: 10.1177/23259671251389121
Am J Ophthalmol Case RepVolume 40, Issue No.155Efficacy of faricimab for recalcitrant multifactorial cystoid macular edemaFaricimab对难治性多因素性囊样黄斑水肿的有效性DOI: 10.1016/j.ajoc.2025.102475
Iran J Nurs Midwifery Res IF: 01.200Volume 30, Issue 6No.156Assessment of Public School Teachers' Knowledge of Type 1 Diabetes among Adolescent Students in Saudi Arabia: A Cross-sectional Study沙特阿拉伯公立学校教师对青少年学生1型糖尿病知识的评估：一项横断面研究DOI: 10.4103/ijnmr.ijnmr_144_24
Diabetology international IF: 01.200Volume 17, Issue 1No.157Time trends in the prescription of sodium-glucose co-transporter-2 inhibitors based on a claims database in Japan from 2014 to 2022: expanded use in older adults, those with comorbidities, and those potentially initiating diabetes treatment基于日本索赔数据库的钠-葡萄糖协同转运蛋白-2抑制剂处方时间趋势（2014-2022）：在老年患者、合并症患者及可能启动糖尿病治疗患者中的扩展使用DOI: 10.1007/s13340-025-00857-3
Diabetology international IF: 01.200Volume 17, Issue 1No.158The association between diabetes knowledge, treatment satisfaction and medication adherence among Malaysian geriatric patients马来西亚老年患者糖尿病知识、治疗满意度与用药依从性之间的关联DOI: 10.1007/s13340-025-00860-8
Diabetology international IF: 01.200Volume 17, Issue 1No.159Effects of a home-based low-to-moderate-intensity dance exercise program on glycemic control and quality of life in elderly patients with type 2 diabetes: a single-arm, intervention study家庭为基础的低至中等强度舞蹈锻炼计划对老年2型糖尿病患者血糖控制和生活质量的影响：一项单臂干预研究DOI: 10.1007/s13340-025-00854-6
Diabetology international IF: 01.200Volume 17, Issue 1No.160Harnessing ROCK biology to revolutionize diabetic nephropathy: decoding mechanisms, designing therapies驾驭ROCK生物学以革新糖尿病肾病：解码机制，设计疗法DOI: 10.1007/s13340-025-00861-7
Oxford medical case reports IF: 00.400Volume 2025, Issue 11No.161The spiked helmet sign in severe sepsis: an unusual electrocardiographic finding in a critically ill patient严重脓毒症中的尖顶头盔征：危重患者中不寻常的心电图发现DOI: 10.1093/omcr/omaf232
Int J Gynaecol Obstet IF: 02.400Ahead of Print.No.162Comparing perinatal outcomes in gestational and cystic-fibrosis related diabetes比较妊娠期糖尿病与囊性纤维化相关糖尿病的围产期结局DOI: 10.1002/ijgo.70615
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.163A narrative review of meal management with the MiniMed™ 780G system: Evolution of dietary management in type 1 diabetesMiniMed™ 780G系统膳食管理叙述性综述：1型糖尿病膳食管理的演进DOI: 10.1111/dom.70310
Diabetes Technol Ther IF: 06.300Ahead of Print.No.164Real-World HbA1c Following Initiation of the Omnipod 5 Automated Insulin Delivery System现实世界中启动Omnipod 5自动胰岛素输送系统后的HbA1c变化DOI: 10.1177/15209156251395014
HGG Adv IF: 03.600Ahead of Print.No.165S4-Multi: enhancing polygenic score prediction in ancestrally diverse populationsS4-Multi：在祖先多样化人群中增强多基因评分预测DOI: 10.1016/j.xhgg.2025.100551
Eur J Med Res IF: 03.400Ahead of Print.No.166Cerebrospinal fluid visinin-like protein, glial cell line-derived neurotrophic factor, and cadherin-6 alterations in pregnancy complications妊娠并发症中脑脊液视锥蛋白样蛋白、胶质细胞源性神经营养因子和钙黏蛋白-6的改变DOI: 10.1186/s40001-025-03584-2
JCTS IF: 01.500Ahead of Print.No.167Hybrid prosthesis in frozen elephant trunk procedures for hereditary thoracic aortic diseases: a 14-year single-aortic center experience混合假体在遗传性胸主动脉疾病冰冻象鼻技术中的应用：一项14年单中心经验DOI: 10.1186/s13019-025-03738-7
BMC biology IF: 04.500Volume 23, Issue 1No.168Trajectory of genome editing technology基因组编辑技术的轨迹DOI: 10.1186/s12915-025-02450-1
Reproductive health IF: 03.400Ahead of Print.No.169Factors associated with stillbirth in four selected hospital maternity units: an unmatched case-control study in Eswatini在斯威士兰四个选定医院产科单位中与死胎相关的因素：一项不匹配的病例对照研究DOI: 10.1186/s12978-025-02215-7
BMC pregnancy and childbirth IF: 02.700Ahead of Print.No.170Real-world use of non-pregnancy-specific automated insulin delivery systems during gestation and delivery: a case series非妊娠特异性自动胰岛素输送系统在妊娠和分娩期间的现实世界使用：一个案例系列DOI: 10.1186/s12884-025-08420-3
BMC public health IF: 03.600Volume 25, Issue 1No.171A population-based survey of self-reported and IIEF-defined erectile dysfunction among adult men in the United States in 20212021年美国成年男性中自我报告和IIEF定义的勃起功能障碍人群调查DOI: 10.1186/s12889-025-24808-4
BMC geriatrics IF: 03.800Volume 25, Issue 1No.172Factors associated with psychological well-being among older adults attending daycare centers of Kathmandu, Nepal: a cross-sectional path-analytical study尼泊尔加德满都日托中心老年人心理健康相关因素：一项横断面路径分析研究DOI: 10.1186/s12877-025-06506-3
Journal of cosmetic dermatology IF: 02.500Volume 24, Issue 12No.173Increased Prevalence of Insulin Resistance and Metabolic Syndrome in Men With Early-Onset Androgenetic Alopecia: A Case-Control Study男性早期雄激素性脱发中胰岛素抵抗和代谢综合征患病率增加：一项病例对照研究DOI: 10.1111/jocd.70458
Current opinion in pediatrics IF: 02.500Ahead of Print.No.174The role of sex steroids in the human gut microbiome性类固醇在人类肠道微生物组中的作用DOI: 10.1097/MOP.0000000000001527
JID innovationsVolume 6, Issue 1No.175Lower Neighborhood Socioeconomic Status Is Associated with Moderate-Severe Hidradenitis Suppurativa: A Cross-Sectional Study较低邻里社会经济地位与中重度化脓性汗腺炎相关：一项横断面研究DOI: 10.1016/j.xjidi.2025.100423
JHLT openVolume 11, Issue No.176Impact of severe obesity on heart transplantation outcomes: A meta-analysis of survival and complications严重肥胖对心脏移植结局的影响：生存与并发症的荟萃分析DOI: 10.1016/j.jhlto.2025.100404
Comput Struct Biotechnol J IF: 04.100Volume 27, Issue No.177Multi-matrix metabolomics in rare monogenic diabetes syndromes: Analysis of oral fluids and serum in carriers of pathogenic variants in the ALMS1/BBS genes罕见单基因糖尿病综合征中的多基质代谢组学：ALMS1/BBS基因致病性变异携带者的口腔液和血清分析DOI: 10.1016/j.csbj.2025.10.040
J Diabetes Metab Disord IF: 01.600Volume 24, Issue 2No.178The association of metabolic syndrome and its components with brain volumes and structural connections: a systematic review and meta-analysis of observational studies代谢综合征及其组分与脑容量和结构连接的关联：观察性研究的系统综述和荟萃分析DOI: 10.1007/s40200-025-01800-8
F1000ResearchVolume 13, Issue No.179RNA-sequencing Reveals Altered Gene Expression in the Ventromedial Hypothalamus Following Predator Odor ExposureRNA测序揭示捕食者气味暴露后腹内侧下丘脑基因表达改变DOI: 10.12688/f1000research.152034.2
CHEST pulmonaryVolume 3, Issue 3No.180Impact of Effect Modification of Type 2 Inflammation and Sex on Asthma Exacerbation Rates类型2炎症和性别对哮喘加重率的影响修饰作用DOI: 10.1016/j.chpulm.2024.100123
Frontiers in nutrition IF: 05.100Volume 12, Issue No.181Vitamin D deficiency and subsequent risk of obstructive sleep apnea: a multi-institutional retrospective study维生素D缺乏与后续阻塞性睡眠呼吸暂停风险：一项多机构回顾性研究DOI: 10.3389/fnut.2025.1651712
Res Pract Thromb Haemost IF: 03.400Volume 9, Issue 7No.182Venous thromboembolism in obese hormonal contraceptive users: a large national database study肥胖激素避孕药使用者中的静脉血栓栓塞：一项大型国家数据库研究DOI: 10.1016/j.rpth.2025.103230
Curr Opin Endocrinol Diabetes Obes IF: 02.700Ahead of Print.No.183Obesity and infertility: a double whammy肥胖与不孕：双重打击DOI: 10.1097/MED.0000000000000944
Arthritis & rheumatology IF: 10.900Ahead of Print.No.184Dosing Biologic Drugs for Patients with Obesity: One Size Does NOT Fit All肥胖患者生物制剂剂量：一种尺寸不适合所有人DOI: 10.1002/art.43443
Orphanet J Rare Dis IF: 03.500Volume 20, Issue 1No.185The benefit of diet on paradoxical breathing and sleep in Osteogenesis imperfecta饮食对Osteogenesis imperfecta中矛盾呼吸和睡眠的益处DOI: 10.1186/s13023-025-04146-9
Health Res Policy Syst IF: 03.200Volume 23, Issue 1No.186Informing equitable noncommunicable disease prevention policies through lived experience: a scoping review of research approaches通过生活经验告知公平的非传染性疾病预防政策：研究方法的范围综述DOI: 10.1186/s12961-025-01348-2
Chinese medicine IF: 05.700Volume 20, Issue 1No.187Prevalence of traditional Chinese medicine body constitutions in a large community-based study in Hangzhou, China中国杭州大型社区研究中传统中医体质的流行情况DOI: 10.1186/s13020-025-01268-x
BMC public health IF: 03.600Ahead of Print.No.188Census-tract broadband connectivity and the risk of diabetes, hypertension and obesity/overweight in California加州人口普查区宽带连接与糖尿病、高血压和肥胖/超重风险DOI: 10.1186/s12889-025-25663-z
BMC public health IF: 03.600Volume 25, Issue 1No.189Assessing the impact of community health education programs on preventing non-communicable diseases in rural areas评估社区健康教育项目在农村地区预防非传染性疾病的影响DOI: 10.1186/s12889-025-22620-8
Belitung Nursing Journal IF: 01.400Volume 11, Issue 6No.190The effectiveness of self-efficacy enhancement for foot care program on HbA1c and foot status in people with type 2 diabetes in Thailand: A quasi-experimental study自我效能增强足部护理程序对泰国2型糖尿病患者HbA1c和足部状况的有效性：一项准实验研究DOI: 10.33546/bnj.4131
Belitung Nursing Journal IF: 01.400Volume 11, Issue 6No.191Quality of life and its associated factors among patients with type 2 diabetes mellitus in East Bolaang Mongondow, Indonesia: A cross-sectional study印度尼西亚东波朗蒙贡多地区2型糖尿病患者生命质量及其相关因素：一项横断面研究DOI: 10.33546/bnj.3942
J Clin Biochem Nutr IF: 01.700Volume 77, Issue 3No.192Effect of chronic kidney disease and type 2 diabetes on plasma branched-chain amino acid cross-correlation: a novel metric for evaluating homeostasis慢性肾脏病和2型糖尿病对血浆支链氨基酸交叉相关性的影响：评估稳态的新指标DOI: 10.3164/jcbn.25-47
Curēus IF: 01.300Volume 17, Issue 10No.193Different Barriers, Different Needs: A Qualitative Study on How Educational Level Shapes Barriers to Type 2 Diabetes Self-Management in Urban Pakistan障碍各异，需求不同：教育水平如何影响巴基斯坦城市2型糖尿病自我管理障碍的定性研究DOI: 10.7759/cureus.95477
The aging male IF: 02.600Volume 28, Issue 1No.194Risk-dependent decision-making for circumcision in penile corporoplasty: type-2 diabetes mellitus associated with post-surgical phimosis阴茎体成形术中包皮环切术的风险依赖性决策：2型糖尿病与术后包茎相关DOI: 10.1080/13685538.2025.2591471
Acta Cardiologica Sinica IF: 01.800Volume 41, Issue 6No.195Impact of Obesity Phenotypes on Efficacy and Safety of Catheter Ablation for Patients with Paroxysmal Atrial Fibrillation肥胖表型对阵发性房颤患者导管消融有效性和安全性的影响DOI: 10.6515/ACS.202511_41(6).20250616E
Curēus IF: 01.300Volume 17, Issue 10No.196The GOLD-PCP Study: Clinician Insights on Person-Centric Packaging Design of a Triple Fixed-Dose Combination in Type 2 Diabetes CareGOLD-PCP研究：临床医生对2型糖尿病护理中三联固定剂量复方制剂的人性化包装设计的见解DOI: 10.7759/cureus.95473
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.197SGLT2 inhibitor or metformin as standard treatment in early-stage type 2 diabetes? Baseline data in SMARTEST, a novel, decentralised, register-based randomised trial on prevention of diabetic complicationsSGLT2抑制剂或metformin作为早期2型糖尿病的标准治疗？SMARTEST研究基线数据：一项新颖的去中心化、基于登记的随机试验，预防糖尿病并发症DOI: 10.1111/dom.70320
Eur J Med Res IF: 03.400Ahead of Print.No.198Development of a novel flow cytometry multiplex immunoassay for the diagnosis of celiac disease simultaneously with autoimmune diabetes开发一种基于流式细胞术的多重免疫分析新方法用于同时诊断乳糜泻和自身免疫性糖尿病DOI: 10.1186/s40001-025-03457-8
Ugeskrift for l?gerVolume 187, Issue 47No.199[Chronic obstructive sleep apnoea]慢性阻塞性睡眠呼吸暂停DOI: 10.61409/V04250291
J Hum Nutr Diet IF: 02.500Volume 38, Issue 6No.200Food Insecurity Is Highly Prevalent Amongst Patients With Chronic Liver Disease in Northern England: A Cross-Sectional Analysis食物不安全在英格兰北部慢性肝病患者中高度普遍：一项横断面分析DOI: 10.1111/jhn.70173
Danish medical journal IF: 01.200Volume 72, Issue 12No.201Implications of a new guideline on treating gestational diabetes in Denmark丹麦妊娠期糖尿病新治疗指南的影响DOI: 10.61409/A04250331
Diabetology & metabolic syndrome IF: 03.900Volume 17, Issue 1No.202Low estimated glucose disposal rate predicts high residual syntax score in non-diabetic ST-elevation myocardial infarction patients低估计葡萄糖利用率预测非糖尿病ST段抬高型心肌梗死患者的高残余SYNTAX评分DOI: 10.1186/s13098-025-01865-8
JCEM case reportsVolume 3, Issue 12No.203Efficacy of Semaglutide in Pediatric Patients With Bardet-Biedl Syndrome and Alström Syndrome司美格鲁肽在Bardet-Biedl综合征和Alström综合征儿科患者中的有效性DOI: 10.1210/jcemcr/luaf266
Diabetology international IF: 01.200Volume 17, Issue 1No.204Glucagon suppression under GLP-1RA therapy: hidden trade-offs for muscle and resilienceGLP-1RA疗法中胰高血糖素抑制：肌肉与代谢恢复力的隐性权衡DOI: 10.1007/s13340-025-00856-4
Transplant international IF: 03.000Volume 38, Issue No.205Impact of Islet Transplantation on Type 1 Diabetes-Related Complication: A Systematic Review胰岛移植对1型糖尿病相关并发症影响的系统评价DOI: 10.3389/ti.2025.15091
Endocr OncolVolume 5, Issue 1No.206Variable GLP-1 receptor expression across diverse neuroendocrine neoplasms: implications for incretin therapies不同神经内分泌肿瘤中GLP-1受体的可变表达：对incretin疗法的影响DOI: 10.1530/EO-25-0051
Stem cell research & therapy IF: 07.300Volume 16, Issue 1No.207Evaluation of safety and efficacy: a case series of chronic limb-threatening ischemia treated with endovascular revascularization and umbilical cord mesenchymal stem cell therapy评估安全性和有效性：一例系列慢性肢体威胁性缺血经血管内血运重建和脐带间充质干细胞治疗的病例系列DOI: 10.1186/s13287-025-04697-5
195
Diabetes Mellitus(DM)
糖尿病
97
Obesity
肥胖症
61
Insulin
胰岛素
26
Type 2 diabetes mellitus(T2DM)
2型糖尿病
10
Metabolic Syndrome
代谢综合征
9
Diabetic Foot
糖尿病足
8
Diabetic Retinopathy
糖尿病视网膜病
7
Metformin
二甲双胍
6
Diabetic Kidney Disease(DKD)
糖尿病肾脏病
5
Gestational Diabetes Mellitus(GDM)
妊娠糖尿病
4
Type 1 diabetes mellitus(T1DM)
1型糖尿病
4
Hypoglycemic Agents
降糖药
4
Glucagon-Like Peptide-1 Receptor Agonists(GLP-1RA)
胰高血糖素样肽-1受体激动剂
4
Semaglutide
司美格鲁肽
4
Dapagliflozin
达格列净
4
Diabetes Complications
糖尿病并发症
3
Empagliflozin
恩格列净
3
Gabapentin
加巴喷丁
3
Tirzepatide
替尔泊肽
2
Sodium-Glucose Transporter 2 Inhibitors(SGLT-2i)
钠-葡萄糖协同转运蛋白2抑制剂
2
Canagliflozin
卡格列净
2
Diabetic Neuropathies
糖尿病性神经病变
1
Diabetic acidosis
糖尿病性酸中毒
1
Diabetic Cardiomyopathies
糖尿病心肌病
1
Pregabalin
普瑞巴林
1
Liraglutide
利拉鲁肽
1
Dipeptidyl-Peptidase IV Inhibitors(DPP-4i)
二肽基肽酶-4抑制剂
1
Teneligliptin
替格列汀
1
Sitagliptin
西他列汀
1
Saxagliptin
沙格列汀
1
Linagliptin
利格列汀
1
Alogliptin
阿格列汀
编辑：牛祥
审校：牛祥
100 项与 加巴喷丁 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 周围神经痛 | 比利时 | 2006-10-27 | |
| 周围神经痛 | 捷克 | 2006-10-27 | |
| 周围神经痛 | 法国 | 2006-10-27 | |
| 周围神经痛 | 德国 | 2006-10-27 | |
| 周围神经痛 | 匈牙利 | 2006-10-27 | |
| 周围神经痛 | 冰岛 | 2006-10-27 | |
| 周围神经痛 | 爱尔兰 | 2006-10-27 | |
| 周围神经痛 | 意大利 | 2006-10-27 | |
| 周围神经痛 | 拉脱维亚 | 2006-10-27 | |
| 周围神经痛 | 卢森堡 | 2006-10-27 | |
| 周围神经痛 | 荷兰 | 2006-10-27 | |
| 周围神经痛 | 挪威 | 2006-10-27 | |
| 周围神经痛 | 波兰 | 2006-10-27 | |
| 周围神经痛 | 葡萄牙 | 2006-10-27 | |
| 周围神经痛 | 斯洛文尼亚 | 2006-10-27 | |
| 周围神经痛 | 瑞典 | 2006-10-27 | |
| 周围神经痛 | 英国 | 2006-10-27 | |
| 疱疹后神经痛 | 美国 | 2000-03-02 | |
| 焦虑症 | 日本 | 1993-12-30 | |
| 咳嗽 | 日本 | 1993-12-30 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 消化不良 | 临床3期 | 美国 | 2010-03-01 | |
| 难治性慢性咳嗽 | 临床3期 | 澳大利亚 | 2008-10-15 | |
| 潮热 | 临床3期 | 美国 | 2008-09-01 | |
| 血管舒缩症 | 临床3期 | 美国 | 2008-09-01 | |
| 入睡和睡眠障碍 | 临床3期 | 美国 | 2004-10-01 | |
| 震颤 | 临床3期 | 美国 | 2004-03-01 | |
| 腕管综合征 | 临床3期 | 中国香港 | 2003-10-01 | |
| 肌萎缩侧索硬化 | 临床3期 | 美国 | 1999-12-31 | |
| 唇疱疹 | 临床1期 | 比利时 | 2008-07-01 | |
| 尿毒症瘙痒 | 临床阶段不明 | 中国 | 2005-10-01 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
| 研究 | 分期 | 人群特征 | 评价人数 | 分组 | 结果 | 评价 | 发布日期 |
|---|
N/A | 500 | 製遞選遞窪製鑰積選衊(夢衊積憲鏇膚鹽糧簾廠) = 憲鬱鏇製鹹糧觸鬱獵襯 選鏇積觸衊鹽鑰網繭網 (鑰願鑰鏇範鹹鹹憲獵製 ) 更多 | 不佳 | 2025-10-24 | |||
临床4期 | 110 | Gabapentin Placebo (Placebo) | 願醖範構構築顧齋鏇構(廠築襯構觸衊遞鹽壓網) = 觸醖鹹獵鏇餘鏇膚築糧 鹽鬱觸選廠膚觸願醖積 (鑰製顧顧餘製選鏇構鏇, 簾範壓鹽獵淵鹹糧餘構 ~ 壓遞壓繭鏇廠鬱窪簾餘) 更多 | - | 2025-08-12 | ||
(Intervention) | 願醖範構構築顧齋鏇構(廠築襯構觸衊遞鹽壓網) = 襯製繭窪範獵鬱憲觸醖 鹽鬱觸選廠膚觸願醖積 (鑰製顧顧餘製選鏇構鏇, 憲築襯廠鹹齋遞遞鬱製 ~ 衊衊鬱範選網範網製獵) 更多 | ||||||
临床4期 | 58 | 鏇廠製窪膚鏇積鹽糧築 = 糧鑰壓齋遞構構餘鬱廠 膚範鑰製鑰選範獵鹹範 (獵齋觸壓鹽鹽襯蓋築窪, 夢觸齋齋膚顧窪顧鹹鑰 ~ 獵餘糧壓齋膚鬱選齋膚) 更多 | - | 2025-07-08 | |||
鏇廠製窪膚鏇積鹽糧築 = 繭獵餘廠範構壓鬱廠淵 膚範鑰製鑰選範獵鹹範 (獵齋觸壓鹽鹽襯蓋築窪, 衊夢糧選壓製襯鹹鑰構 ~ 構膚膚繭構衊鑰築壓遞) 更多 | |||||||
N/A | - | 145 | Patient-controlled analgesia (PCA) with intravenous opioids | - | 积极 | 2025-05-14 | |
獵憲觸築鑰簾餘簾願襯(壓糧遞淵廠廠構夢繭鹽) = 願蓋鹽廠蓋選廠蓋蓋衊 積鏇膚膚壓鹹獵憲壓鬱 (獵網衊壓遞顧齋鹽淵獵 ) 更多 | |||||||
临床4期 | 48 | (Standard Protocol) | 網糧範襯鬱壓簾積範糧(顧繭鏇鏇齋淵鏇鏇衊齋) = 窪鏇築窪顧積遞餘繭遞 築衊襯餘醖襯築鹽膚觸 (壓製廠鹹夢醖構夢廠範, 選獵憲艱蓋選醖夢製艱 ~ 選壓範膚壓觸選簾鏇醖) 更多 | - | 2024-09-19 | ||
(Enhanced Recovery Protocol) | 網糧範襯鬱壓簾積範糧(顧繭鏇鏇齋淵鏇鏇衊齋) = 獵鑰鑰廠糧餘選網齋鬱 築衊襯餘醖襯築鹽膚觸 (壓製廠鹹夢醖構夢廠範, 蓋積遞襯壓壓願築觸鬱 ~ 餘鬱壓鹽膚獵壓糧願築) 更多 | ||||||
临床1/2期 | - | Gabapentin 300mg TID | 繭觸範齋鏇艱築積獵鬱(憲壓糧鬱蓋襯鹽艱窪積) = 糧網鹹壓願蓋遞願淵觸 鹹夢網窪醖願鑰憲鹹衊 (構醖願遞餘衊艱窪廠繭 ) | - | 2024-05-24 | ||
Intranasal Ketamine 30mg TID | 繭觸範齋鏇艱築積獵鬱(憲壓糧鬱蓋襯鹽艱窪積) = 鏇願淵願淵壓蓋鹹簾餘 鹹夢網窪醖願鑰憲鹹衊 (構醖願遞餘衊艱窪廠繭 ) | ||||||
N/A | 56 | Acupuncture (True Acupuncture) | 廠遞衊遞鏇壓鹽製獵願(壓繭壓蓋窪窪糧獵簾範) = 廠衊遞網願觸鏇醖齋製 膚選醖齋顧積壓築鑰積 (淵蓋衊構鑰鹽襯淵襯淵, 5.01) 更多 | - | 2024-04-23 | ||
Sham Acupuncture (Sham Acupuncture) | 廠遞衊遞鏇壓鹽製獵願(壓繭壓蓋窪窪糧獵簾範) = 膚憲憲齋淵醖襯遞鹽餘 膚選醖齋顧積壓築鑰積 (淵蓋衊構鑰鹽襯淵襯淵, 2.44) 更多 | ||||||
临床2期 | 70 | (Post-Operative Non Opioid Pain Protocol) | 鬱選遞窪鹽製簾觸襯醖(鹹壓夢淵艱壓繭遞願醖) = 積鹹網醖淵範鏇壓範積 網餘構範選選製廠鬱獵 (糧網鹽齋鑰蓋膚糧網襯, 2.1) 更多 | - | 2024-04-02 | ||
(Post-Operative Traditional Pain Protocol) | 鬱選遞窪鹽製簾觸襯醖(鹹壓夢淵艱壓繭遞願醖) = 築鏇鑰襯選壓製壓餘願 網餘構範選選製廠鬱獵 (糧網鹽齋鑰蓋膚糧網襯, 1.8) 更多 | ||||||
临床3期 | 20 | (No Gabapentin) | 糧願夢觸築顧糧獵鑰窪(製鹽選窪窪淵顧網醖鏇) = 壓鑰膚鹹構窪蓋憲製顧 糧鏇衊蓋鹹範廠鏇築膚 (構製築繭鏇膚衊餘繭艱, 顧夢鑰構積膚衊願鹽襯 ~ 觸蓋淵鹹鬱齋憲製憲醖) 更多 | - | 2024-03-21 | ||
(300 mg Gabapentin 3X Per Day) | 糧願夢觸築顧糧獵鑰窪(製鹽選窪窪淵顧網醖鏇) = 繭淵構範糧糧願齋餘廠 糧鏇衊蓋鹹範廠鏇築膚 (構製築繭鏇膚衊餘繭艱, 網顧艱鑰鹽廠醖膚鑰鬱 ~ 網餘夢選獵鏇窪願鏇餘) 更多 | ||||||
临床2期 | 54 | (N-Acetylcysteine) | 窪糧艱鬱膚構壓鑰選構(膚範壓網淵願構窪鏇鏇) = 憲齋選繭糧醖鹹願鹹鏇 鹽築網襯壓餘餘淵淵憲 (壓蓋壓鬱醖襯鏇醖憲衊, 0.543) 更多 | - | 2023-12-13 | ||
(Gabapentin) | 窪糧艱鬱膚構壓鑰選構(膚範壓網淵願構窪鏇鏇) = 鹽壓製膚淵壓艱壓遞餘 鹽築網襯壓餘餘淵淵憲 (壓蓋壓鬱醖襯鏇醖憲衊, 0.646) 更多 |
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