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更新于：2025-11-26
Gabapentin
加巴喷丁
更新于：2025-11-26
概要
基本信息
简介Gabapentin 是辉瑞公司开发的一种小分子药物，可作为 CACNA2D2 和 Cav2.2 阻断剂发挥作用。该药物已被批准用于治疗各种疾病，包括焦虑、咳嗽、糖尿病性神经病变、癫痫、纤维肌痛、不宁腿综合征和癫痫发作。加巴喷丁的作用机制包括阻断钙离子流入神经元，从而降低其兴奋性，缓解疼痛和抽搐等症状。自 1993 年首次获得批准以来，加巴喷丁已成为治疗这些疾病的广泛处方药。但需要注意的是，加巴喷丁可能会引起某些副作用，如嗜睡、头晕、协调困难等。因此，其使用必须由医疗保健提供者密切监测，患者应遵循规定的剂量和使用指南。 |
药物类型 小分子化药 |
别名 1-(Aminomethyl)cyclohexaneacetic acid、Gabapentin (JAN/USP/INN)、CI-945 + [16] |
作用方式 阻滞剂 |
作用机制 CACNA2D1阻滞剂(电压门控性钙通道α2/δ亚基-1阻滞剂)、CACNA2D2阻滞剂(电压门控性钙通道α2/δ亚基-2阻滞剂) |
原研机构 |
最高研发阶段批准上市 |
最高研发阶段(中国)撤市 |
特殊审评孤儿药 (美国) |
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结构/序列
分子式C9H17NO2 |
InChIKeyUGJMXCAKCUNAIE-UHFFFAOYSA-N |
CAS号60142-96-3 |
关联
696
项与 加巴喷丁 相关的临床试验NCT07158476
Efficacy of Methylprednisolone for Pain Control After ACL Repair: A Randomized Controlled Trial
Opioids are commonly used after orthopedic surgery for pain control but have been shown to increase complications, surgeries, readmissions, and risk for opioid use disorder. The purpose of this study is to investigate the impact of adding a methylprednisolone taper to the pain regimen after ACL repair surgery to determine if this results in decreased postoperative pain and opioid use without increasing complications.
开始日期2025-10-21 |
申办/合作机构 |
NCT06997016
Enhanced Recovery After Surgery (ERAS) in Live Donor Kidney Transplant Recipients
The goal of this interventional study is to learn if an Enhanced Recovery After Surgery (ERAS) protocol works to reduce the need for narcotic pain medications in live donor kidney transplant recipients. The main questions it aims to answer are:
Does the ERAS protocol lower the amount of opioid narcotic medication needed to manage post-surgery pain? Does the ERAS protocol help lower pain scores after surgery? Researchers will compare the ERAS protocol to previous patients where the ERAS protocol was not used to see if the ERAS protocol works to reduce post-surgery pain.
Participants will be asked to:
* Drink a pre-surgery carbohydrate drink two hours before your surgery.
* Take a pre-surgery dose of Tylenol by mouth.
* Take a pre-surgery dose of Gabapentin by mouth.
* The surgeon will administer a local numbing medication at the surgery site by injection during the surgery.
* Begin walking with assistance about 12 hours after your surgery.
* Allow the research staff to collect data about your kidney function. This data will be collected on your postoperative clinic visits, which generally occur about twice weekly for one month. This information will determine your kidney health, need for hospitalization, and side effects that may occur.
Does the ERAS protocol lower the amount of opioid narcotic medication needed to manage post-surgery pain? Does the ERAS protocol help lower pain scores after surgery? Researchers will compare the ERAS protocol to previous patients where the ERAS protocol was not used to see if the ERAS protocol works to reduce post-surgery pain.
Participants will be asked to:
* Drink a pre-surgery carbohydrate drink two hours before your surgery.
* Take a pre-surgery dose of Tylenol by mouth.
* Take a pre-surgery dose of Gabapentin by mouth.
* The surgeon will administer a local numbing medication at the surgery site by injection during the surgery.
* Begin walking with assistance about 12 hours after your surgery.
* Allow the research staff to collect data about your kidney function. This data will be collected on your postoperative clinic visits, which generally occur about twice weekly for one month. This information will determine your kidney health, need for hospitalization, and side effects that may occur.
开始日期2025-10-15 |
申办/合作机构 |
NCT07047040
Analgesic Efficacy of Pre-operative Dose of Ketorolac And Gabapentin in Patients Undergoing Unilateral Total Knee Arthroplasty A Randomized Double Blinded Controlled Trial
Evaluation of the analgesic efficacy of a pre-operative dose of ketorolac and gabapentin in reducing post-operative pain scores in patients undergoing TKA
开始日期2025-08-15 |
申办/合作机构 |
100 项与 加巴喷丁 相关的临床结果
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100 项与 加巴喷丁 相关的转化医学
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100 项与 加巴喷丁 相关的专利（医药）
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10,687
项与 加巴喷丁 相关的文献（医药）2026-03-01·Medical Gas Research
Effects of pulsed radiofrequency combined with ozone on zoster-associated pain: a systematic review and meta-analysis
Review
作者: Shen, Qiu-Song ; Kan, Hou-Ming ; Ding, Xiao-Tong ; Huang, Jin-Zhao ; Wang, Rui-Yu
Pulsed radiofrequency combined with ozone therapy has been a newly proposed treatment method for zoster-associated pain in recent years. To explore the effectiveness of a regimen of pulsed radiofrequency combined with ozone for the treatment of zoster-associated pain. We searched commonly used English databases (the Cochrane Library, PubMed, CINAHL, Embase, and Web of Science) and Chinese databases (the CNKI, WanFang, CBM, and VIP databases) for randomized controlled trials. Two researchers independently screened the literature on the basis of the set conditions and extracted data from the included literature. The meta-analysis was conducted via Review Manager 5.4 software. A meta-analysis was conducted on 18 studies, with a total of 1496 participants (742 in the experimental group and 754 in the control group). The results revealed that the pulsed radiofrequency combined with ozone presented lower unidimensional pain scores (standardized mean difference [SMD] = −1.55, 95% confidence interval [CI] = [−2.04, −1.06]; heterogeneity: P < 0.00001, I2 = 94%; test effect: Z = 6.18, P < 0.00001), a lower pain rating index (mean difference [MD] = −2.65, 95% CI = [−3.86, −1.44]; heterogeneity: P = 0.001, I2 = 85%; test effect: Z = 4.29, P < 0.0001) and presented pain intensity scores (MD = −0.58, 95% CI = [−0.62, −0.54]; heterogeneity: P = 0.61, I2 = 0%; test effect: Z = 27.91, P < 0.00001), a lower Pittsburgh sleep quality index (MD = −1.62, 95% CI = [−2.94, −0.31]; heterogeneity: P < 0.00001, I2 = 93%; test effect: Z = 2.42, P = 0.02), and lower interleukin-6 expression levels (SMD = −1.94, 95% CI = [−2.91, −0.97]; heterogeneity: P < 0.00001, I2 = 93%; test effect: Z = 3.92, P < 0.0001), lower gabapentin consumption (MD = −146.92, 95% CI = [−189.93, −103.91]; heterogeneity: P = 0.23, I2 = 30%; test effect: Z = 6.70, P < 0.00001). Pulsed radiofrequency combined with ozone is an effective treatment for zoster-associated pain that can effectively alleviate patients’ pain and improve sleep quality, providing a new treatment option for zoster-associated pain in the future.
2026-02-01·Biomaterials advances
Multimodal topical gel combining 2-hydroxyflavanone, gabapentin, and ketamine alleviates diabetic vulvodynia and allodynia with concurrent tissue regeneration in streptozocin-induced rat models
Article
作者: Bashir, Nasreena ; Ayyaz, Fatima ; Ali, Gowhar ; Islam, Nazar-Ul- ; Ayaz, Muhammad ; Khan, Pordil ; Qayyum, Jibran ; Mir, Mushtaq Ahmad
Neuropathic pain arises from damage or illness affecting either central or peripheral or both somatosensory systems. Vulvodynia, a chronic neuropathic pain disorder in women, remains largely neglected despite its significant impact. This study was aimed to evaluate safety and efficacy of a multimodal analgesic gel (MMG-10 %) in relieving diabetic neuropathic pain; specifically vulvodynia and allodynia in female rats. We have formulated a highly promising flavonoid, 2'-Hydroxyflavanone (2-HF) with gabapentin and ketamine. Streptozotocin-induced Diabetes Mellitus (DM) was used as a painful neuropathic model. Static and dynamic vulvodynia and allodynia were assessed using parameters including Flinching Response Threshold (FRT), Paw Withdrawal Threshold (PWT), Flinching Response Latency (FRL) and Paw withdrawal Latency (PWL) by applying the stimuli of Von Frey Filaments to the vulvar region and hind mid-planter regions of paws. A uniform quantity for five consecutive days post 29 days of MMG-10 % and control gel (1.0 mg/cm2) was applied three times daily (TDS) on vulvar area for vulvodynia and mid-plantar paws for allodynia studies. Safety with respect to sensorimotor functions was assessed via Rota rod and Balance beam tests. We conducted the vulvar histological tissue study to evaluate diabetes-induced structural damage and assess the therapeutic potential of a multimodal gel in tissue regeneration. Treatment with tested MMG 10 % resulted in a significant increase in FRT, PWT, FRL and PWL respectively (***p < 0.001, ** p < 0.01, p > 0.05) compared to the STZ treated group. Falling latency time was not affected in all treated groups exhibiting sensorimotor safety. The multimodal gel demonstrated significant regenerative efficacy by reducing atrophy, desquamation, and hyperkeratosis, effectively restoring vulvar tissue integrity in diabetic animals. Our MMG-10 %) could be potentially an effective therapeutic remedy for the relief against diabetes-induced vulvodynia and allodynia.
2026-01-01·WATER RESEARCH
Investigation of reaction mechanisms of ozone with amines: evaluation of 18O isotopic labeling techniques in aqueous solution
Article
作者: Ra, Jiwoon ; von Gunten, Urs
Reaction mechanisms of amine compounds with ozone were investigated with 18O isotope labeling of the final products, nitrate and aldehydes (or ketones), for varying concentrations of 18O-labeled water. For oximes and gabapentin, nitrate and aldehydes showed an increased 18O isotopic ratio/composition for higher proportions of 18O-labeled water, while no effect was observed for amino acids, peptidic amino groups, and aliphatic (or aryl-type) primary amines. Gabapentin might react through an oxime intermediate involving oxygen exchange with water during the ozone reaction. In contrast, amino acids, peptidic amino groups, and aliphatic (or aryl-type) primary amines might have nitroalkanes as common reaction intermediates, which do not involve oxygen exchange with water during ozone transformation reactions. The 18O isotopic composition of aldehydes was significantly influenced by oxygen exchange through hydration, even after the ozone reaction was complete. Thus, 18O isotopic composition of aldehydes is unsuitable for mechanistic studies. In contrast, formation of ketones and carboxylic acids was not affected by hydration, indicating that their 18O isotopic composition could be used to assess reaction intermediates. However, since aldehydes are typical precursors to carboxylic acids during ozonation, the source of oxygen in carboxylic acids remains inconclusive due to the hydration of aldehydes. Overall, the use of 18O-labeled ozone or water for elucidating ozone-induced reaction mechanisms cannot be generally applied and has to be critically evaluated for each reaction system.
154
项与 加巴喷丁 相关的新闻（医药）2025-11-19
过去十年，猫科医学的治疗格局正被创新药物与经典疗法的优化迭代彻底重塑。从疼痛管理到致命传染病治疗，从慢性肾病到心血管疾病，一系列针对性药物的涌现，不仅破解了临床治疗的诸多难题，更为药物开发者提供了清晰的创新方向。基于发表在Journal of Feline Medicine and Surgery 中的文章，本文整合权威临床综述核心数据，从作用机制、临床应用、研发亮点三个维度，为药物开发者与临床医生呈现猫科药物的最新全景、。
一、疼痛管理类药物
疼痛是猫科临床最常见的诉求，这类药物的核心研发趋势是 “延长作用时间、优化给药方式、降低不良反应”，同时覆盖术后疼痛、慢性骨关节痛等多场景需求。
丁丙诺啡（Buprenorphine）：长效制剂引领革新
作为脂溶性阿片类药物，丁丙诺啡通过部分激动 μ 受体、拮抗 κ 受体发挥轻中度镇痛作用，全身不良反应少于其他阿片类药物。其研发突破集中在新型制剂：
高浓度皮下注射剂（1.8mg/ml）：术前 1 小时给药，术后镇痛可持续 24 小时，软组织手术后 72 小时内无需追加镇痛药物的比例达 66/93；
透皮溶液（20mg/ml）：涂抹于颈背部皮肤，通过角质层缓释实现长效镇痛，绝育手术后 96 小时内无不良事件发生率达 80%（89/112）。
研发关键点：利用药物与 μ 受体的慢解离特性和天花板效应控制不良反应，同时解决传统剂型需 24 小时内重复给药的痛点，但需注意部分猫可能出现高热、散瞳等反应，严重时需多次使用纳洛酮逆转。
普瑞巴林（Pregabalin）与加巴喷丁（Gabapentin）：焦虑与疼痛的双重解决方案
两者均作用于中枢神经系统电压门控钙通道 α-2-δ 亚基，减少兴奋性神经递质释放，核心差异在于药代动力学与临床定位：
普瑞巴林：口服生物利用度高达 94%，半衰期 14.7 小时，单次给药即可缓解兽医就诊相关焦虑，同时可作为神经病理性疼痛的辅助治疗；
加巴喷丁：口服吸收受食物影响小，半衰期 2.8-3.8 小时，更适合作为镇静剂使用，慢性肾病猫需减量，镇痛证据较弱，建议作为多模式镇痛的一部分。
研发启示：针对猫对压力的高敏感性，“镇痛 + 抗焦虑” 双效设计可提升临床适用性，液体混悬剂型更易给药，提高宠主依从性。
Frunevetmab单抗：靶向骨关节痛的单克隆抗体
作为猫特异性抗神经生长因子（NGF）单克隆抗体，通过阻断 NGF 介导的疼痛传导，专门用于骨关节炎镇痛。每 28 天皮下注射一次，两次给药后可达稳态浓度，临床研究显示能显著改善患猫活动能力。
二、代谢与内分泌疾病药物
糖尿病、慢性肾病相关贫血等代谢性疾病是猫科常见病，这类药物的研发核心是 “靶向病理机制、减少依赖、降低并发症”。
SGLT2 抑制剂：糖尿病治疗的口服新选择
通过阻断肾脏近端小管 SGLT2 受体，减少葡萄糖重吸收，实现尿糖排泄降糖，无需依赖内源性或外源性胰岛素：
制剂差异：贝格列净为 15mg 片剂，食物可促进吸收；维格列净为 15mg/ml 口服溶液，食物会降低吸收；
临床数据：新诊断糖尿病猫使用后，血糖快速降至正常水平，部分猫可改善胰岛素敏感性，但需警惕糖尿病酮症酸中毒（发生率 5-7%），治疗前需排除胰腺炎、脱水等禁忌症。
研发亮点：针对猫 2 型糖尿病的病理特点，规避传统胰岛素注射的依从性问题，但需严格监测治疗前 2 周的尿酮体与酸碱状态。
莫利司他（Molidustat）：慢性肾病贫血的创新疗法
作为缺氧诱导因子脯氨酰羟化酶（HIF-PH）抑制剂，通过稳定 HIF 促进内源性促红细胞生成素分泌，无需额外注射促红素：
给药方案：口服混悬液，5mg/kg 每日一次，连续使用 28 天需停药 7 天；
临床效果：慢性肾病贫血猫治疗 28 天后，50% 出现红细胞压积显著升高（>25% 或绝对增加≥4%）；
研发优势：相比传统促红素，口服剂型更便捷，且可能无需补充铁剂（人类研究显示可降低铁调素），但需监测高血压、高钾血症等不良反应。
卡莫瑞林（Capromorelin）：慢性肾病相关体重下降的食欲调节剂
作为生长激素促分泌剂，通过激活饥饿素受体促进食欲与生长激素分泌，专门用于慢性肾病猫的体重管理：
药代动力学：空腹给药后 0.25-1 小时达峰浓度，半衰期 1.1 小时，食物会使峰浓度降低 50%；
注意事项：可能导致血糖短暂升高，糖尿病猫需谨慎使用，禁止用于肢端肥大症患猫。
三、感染性疾病药物
猫传染性腹膜炎（FIP）曾是致死率近 100% 的疾病，瑞德西韦与 GS-441524 的研发成功彻底改变了这一现状。
瑞德西韦（Remdesivir）与 GS-441524：冠状病毒的精准抑制
作用机制：瑞德西韦为前药，在体内转化为 GS-441524 三磷酸代谢物，抑制冠状病毒 RNA 依赖的 RNA 聚合酶，阻断病毒复制；
临床应用：根据感染类型调整剂量，渗出性 FIP 瑞德西韦剂量 15mg/kg 静脉注射，中枢神经系统受累时 GS-441524 需增至 10mg/kg 每日两次；
关键数据：75-100% 患猫在 48-72 小时内出现临床改善，渗出性 FIP 治疗周期可缩短至 42 天，无明显不良反应，但非法制剂可能导致尿石症。
研发价值：针对病毒复制关键酶的靶向设计，为动物冠状病毒疾病治疗提供模板，口服制剂的开发进一步提升可及性。
四、心血管与血栓疾病药物
肥厚型心肌病（HCM）、主动脉血栓栓塞（ATE）等疾病风险高，药物研发聚焦 “抗血栓、延缓病程、降低侵袭性”。
雷帕霉素（Rapamycin）：心肌病的潜在新疗法
通过抑制哺乳动物雷帕霉素靶蛋白（mTOR），减少心肌肥厚，改善自噬活性，已获 FDA 有条件批准用于亚临床 HCM 的心室肥厚管理。
给药方案：每周口服一次，0.3mg/kg 剂量可显著降低左心室壁厚度，同时具有抗炎与潜在抗凝作用；
研发方向：针对 HCM 的多因素病理机制，mTOR 通路抑制为慢性心血管疾病提供了 “延缓进展” 而非单纯对症的治疗思路，但需监测血糖升高风险。
利伐沙班（Rivaroxaban）：口服抗凝的新选择
直接抑制凝血因子 Xa，减少凝血酶生成，用于预防 HCM 相关血栓形成。口服生物利用度高，2.5 小时达峰浓度，半衰期 7.5 小时，可替代传统注射用肝素。
注意要点：严重肝病猫禁用，慢性肾病猫需慎用，与氯吡格雷联用时出血风险增加（15%），需避免突然停药。
替米沙坦（Telmisartan）：高血压与蛋白尿的双重管理
作为血管紧张素 II 受体拮抗剂，选择性阻断 AT1 受体，同时改善慢性肾病相关蛋白尿。口服溶液 10mg/ml，初始剂量 1.5mg/kg 每日两次，14 天后调整至 2mg/kg 每日一次。
临床优势：相比血管紧张素转换酶抑制剂，对蛋白尿的改善效果更显著，57.2% 患猫可从蛋白尿转为非蛋白尿状态，但需监测肾功能与血钾。
五、泌尿系统与其他疾病药物
坦索罗辛（Tamsulosin）：尿路梗阻的辅助治疗
选择性 α1A/1D 受体拮抗剂，放松尿路平滑肌，用于输尿管结石梗阻的医疗管理，31%（22/70）患猫可实现结石排出，但对尿道远端骨骼肌梗阻效果有限，需注意低血压风险。
核心研发与临床应用建议：
剂型优先：猫对口服片剂依从性低，液体混悬液、透皮制剂、长效注射剂更具临床优势，同时可通过调味提升接受度；
安全性设计：猫的肝脏代谢与肾脏排泄特性独特，需针对性开展药代动力学研究，避免照搬犬或人类剂量，慢性肾病、肝病猫的剂量调整方案需明确；
靶向性研发：单克隆抗体、通路抑制剂等靶向药物可提高疗效、减少不良反应，如 NGF 抗体、HIF-PH 抑制剂等，是未来研发热点；
临床监测要点：新疗法需明确监测指标，如 SGLT2 抑制剂需监测酮体，雷帕霉素需监测血糖，确保治疗安全。
内容来源：《Clinical therapeutics in feline medicine updates for old andnew drugs》
链接🔗：
兽药手册｜Zorbium（丁丙诺啡透皮溶液）-猫咪术后止痛
兽药手册｜猫咪出行、就医焦虑？Bonqat（普瑞巴林） 来帮忙！
兽药手册｜卡莫瑞林口服溶液-猫体重减轻
铲屎官必看！猫咪糖尿病新药 Bexacat （贝格列净）全解析
兽药手册｜Senvelgo (维格列净)-猫糖尿病治疗口服溶液
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2025-11-18
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截至11月18日15点59分，近期共有 397 本期刊发布了 941 篇文章，其中糖尿病相关的文章共 343 篇，覆盖 35 个领域的内容。中国专家参与发表的文章有 94 篇。今日，影响因子最高的文章刊登在 Journal of the American Medical Association (IF: 55.000) 期刊上。
今日头条
Headlines
01 International journal of surgery IF: 10.100 袖状胃切除术与Roux-en-Y胃旁路术用于治疗2型糖尿病合并肥胖：随机对照试验的系统综述和荟萃分析
Cheng, Yuanchao, Xie, Yuchen, Sun, Wenjuan, Chen, Chen, Li, Chanjuan, Pérez-López, Faustino R, etc.
一项发表在International Journal of Surgery的研究系统比较了袖状胃切除术（SG）与Roux-en-Y胃旁路术（RYGB）对2型糖尿病（T2DM）合并肥胖患者的治疗效果。该研究由Cheng Yuanchao等人完成，旨在评估不同手术方式在T2DM缓解和肥胖管理中的差异，特别关注了不同缓解标准（如HbA1c阈值）和随访时长对治疗终点的影响。
研究团队对22项随机对照试验进行了系统综述和荟萃分析，共纳入1500名患者。采用随机效应模型比较了RYGB和SG组在T2DM和肥胖相关指标上的差异，并通过试验序列分析验证了结果的稳定性。分析涵盖了1年、3年和5年的随访数据，以全面评估手术的长期效果。
结果显示，RYGB在短期（＜3年）随访期内表现更优。在T2DM缓解方面，在使用HbA1c<6.0或HbA1c<6.5作为缓解目标时，RYGB组在1年和3年时的缓解率显著高于SG组。RYGB组在术后1年和3年时的T2DM缓解率更佳，HbA1C水平更低，但5年时两组之间的这些差异均无统计学意义。此外，RYGB在改善血脂方面也显示出优势，总胆固醇和低密度脂蛋白（LDL）的降低幅度更大。
研究结论指出，与SG相比，RYGB在短期（<3年）内对T2DM缓解率和血脂管理具有更佳效果，而在长期随访中差异不显著。这一发现揭示了不同T2DM缓解标准在评估手术结局时的影响，为临床决策提供了依据。
本文由 韩玉莲 编辑
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International journal of surgery | Ahead of Print.
10.1097/JS9.0000000000003894
02 Frontiers in nutrition IF: 05.100 肥胖指标、胰岛素抵抗标志物与中国中老年人骨关节炎的关联
Zhang, Suyao, Jiang, Zhen, Liao, Huayuan, Bian, Huwei, Zhou, Junan, Wang, Haibo, etc.
南京中医药大学常州附属医院Zhang Suyao等最新发表的一项基于中国健康与养老追踪调查（CHARLS）数据的研究揭示，肥胖指标和胰岛素抵抗替代标志物与中老年人骨关节炎（OA）风险存在显著关联。该研究分析了2011年至2020年的全国性数据，旨在评估多种代谢指标在OA早期筛查中的价值。
研究纳入10,457名45岁及以上参与者进行横断面分析，其中3,667人诊断为OA。通过多变量逻辑回归模型，在完全校正混杂因素后，发现所有作为连续变量的指标包括体脂百分比（BFP）、脂质积累产物（LAP）、体重指数（BMI）、腰围身高比（WHtR）等肥胖指标，以及甘油三酯-葡萄糖指数（TyG）及其衍生指标（TyG-WC、TyG-BMI、TyG-WHtR），均与OA风险呈正相关（（P<0.05））。
进一步通过受试者工作特征曲线分析，比较各指标诊断性能。结果显示，TyG-WHtR的曲线下面积（AUC）达0.680，优于其他指标，其敏感性和特异性分别为0.681和0.579，表明该指标在OA风险预测中具有较高应用潜力。
为验证结果的稳健性，研究团队进行了纵向队列分析，对5,718名基线无OA的参与者中位随访108个月。多变量Cox回归表明，TyG-WHtR每增加1单位，OA发病风险升高20%（HR=1.20）。当按四分位分组时，最高组较最低组风险增加46%，且存在显著剂量反应关系（P<0.05）。
该研究系统评估了多种肥胖和胰岛素抵抗（IR）替代标志物在中国中老年人群中的OA预测价值。其中，TyG WHtR显示出最强的预测性能，表明其作为OA早期筛查工具的潜力。本研究强调肥胖和IR是可改变的危险因素，为OA的早期预防和控制提供了依据。
本文由 韩玉莲 编辑
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Frontiers in nutrition | Volume 12, Issue
10.3389/fnut.2025.1627421
03 Diabetes, obesity & metabolism IF: 05.700 荷兰2型糖尿病患者口服司美格鲁肽治疗的临床结局真实世界评估：一项使用PHARMO数据网络的回顾性观察性队列研究
Postema, Abigail, Gaspersz, Jordy, Baak, Brenda N, Huisman, Eline L, Hoogstraten, Charlotte, Hagelund, Lise Meinicke, etc.
一项针对荷兰2型糖尿病患者口服司美格鲁肽治疗临床结局的真实世界评估研究近日发表于Diabetes, Obesity & Metabolism期刊。该研究采用回顾性观察性队列设计，利用PHARMO数据网络，旨在评估口服司美格鲁肽在常规临床实践中的效果。
研究覆盖了2020年1月1日至2022年12月31日期间启动口服司美格鲁肽的GLP-1受体激动剂初治型2型糖尿病患者。从数据网络中识别出932例患者，其中731例未曾使用过GLP-1受体激动剂，平均年龄为62岁，基线HbA1c为70 mmol/mol，基线体重为102 kg。
在12个月随访期内，对320例患者（平均随访8.1个月）的分析显示，HbA1c平均降低16.05 mmol/mol，且70%的患者达到个体化HbA1c目标。同时，在260例患者（平均随访8.2个月）中，体重平均减少4.73 kg。
研究还评估了其他临床参数，包括血脂和血压变化。结果显示，血脂参数和舒张压变化极小，而收缩压表现出中度变化。
这项研究基于真实世界数据，证实口服司美格鲁肽在荷兰GLP-1受体激动剂初治2型糖尿病患者中能显著改善血糖控制和体重管理，这一结果与前瞻性临床试验数据一致。这些研究结果为荷兰早期采用口服司美格鲁肽患者的真实世界血糖控制和体重减轻提供了初步数据。
本文由 韩玉莲 编辑
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Diabetes, obesity & metabolism | Ahead of Print.
10.1111/dom.70251
中国发表（94）
China
J Gen Intern Med IF: 04.200Ahead of Print.No.01Effects of Glucagon-Like Peptide-1 Receptor Agonists After Treatment Withdrawal: A Systematic Review and Meta-AnalysisGLP-1受体激动剂停药后效果的系统综述与荟萃分析DOI: 10.1007/s11606-025-09950-4
Cell death and differentiation IF: 15.400Ahead of Print.No.02HERP constrains white adipose expansion and inflammation by STEAP4 stabilizationHERP通过STEAP4稳定化抑制白色脂肪扩张和炎症DOI: 10.1038/s41418-025-01608-2
Scientific reports IF: 03.900Volume 15, Issue 1No.03Author Correction: Preliminary evidence of immune infiltration and neutrophil degranulation in peripheral blood of non-obese OSA patients related to cognitive decline作者更正：非肥胖OSA患者外周血中免疫浸润和中性粒细胞脱颗粒与认知下降相关的初步证据DOI: 10.1038/s41598-025-27943-5
J Steroid Biochem Mol Biol IF: 02.500Ahead of Print.No.04Urinary metabolomic biomarkers for diagnosing central precocious puberty and revealing sexual dimorphism尿液代谢组学生物标志物用于诊断中枢性性早熟及揭示性别二态性DOI: 10.1016/j.jsbmb.2025.106901
Journal of Advanced Research IF: 13.000Ahead of Print.No.05Glycyrrhetinic acid augments lipid catabolism via immune-neural modulation in adipose tissue甘草次酸通过免疫神经调节增强脂肪组织中的脂质分解代谢DOI: 10.1016/j.jare.2025.11.019
Scientific reports IF: 03.900Volume 15, Issue 1No.06Molecular mechanisms of olanzapine against agitation in schizophrenia and bipolar disorder based on network pharmacology and molecular docking基于网络药理学和分子对接的奥氮平对抗精神分裂症和双相障碍中激越症状的分子机制DOI: 10.1038/s41598-025-24139-9
npj science of food IF: 07.800Volume 9, Issue 1No.07Protective effects of Parabacteroides distasonis against high-fat diet-induced brain injury in miceParabacteroides distasonis 对高脂饮食诱导的小鼠脑损伤的保护作用DOI: 10.1038/s41538-025-00591-9
ENeuro IF: 02.700Ahead of Print.No.08A Positive Relationship Exists Between the Triglyceride to Glucose Index and Waist to Hip Ratio with Stroke Risk in Middle Aged and Older Chinese甘油三酯-葡萄糖指数与腰臀比与中老年中国人卒中风险呈正相关关系DOI: 10.1523/ENEURO.0264-25.2025
Psychiatry research IF: 03.900Ahead of Print.No.09Associations between maternal lipid metabolism and immune characteristics in children with autism spectrum disorder母体脂质代谢与自闭症谱系障碍儿童免疫特征之间的关联DOI: 10.1016/j.psychres.2025.116833
Nature communications IF: 15.700Volume 16, Issue 1No.10Multivariate genome-wide analyses of insulin resistance unravel novel loci and therapeutic targets for cardiometabolic health多变量全基因组分析揭示胰岛素抵抗的新基因位点和心脏代谢健康治疗靶点DOI: 10.1038/s41467-025-64985-9
npj science of food IF: 07.800Volume 9, Issue 1No.11Metabolomic signature of ultraprocessed food consumption and microvascular complications among individuals with type 2 diabetes超加工食品消费的代谢组学特征与2型糖尿病患者微血管并发症DOI: 10.1038/s41538-025-00597-3
Cell death and disease IF: 09.600Volume 16, Issue 1No.12MSCs ameliorates hyperglycemia-induced endothelial injury through modulation of mitochondrial dynamics间充质基质细胞通过调节线粒体动力学改善高血糖诱导的内皮损伤DOI: 10.1038/s41419-025-08175-x
Nutrition & diabetes IF: 05.200Volume 15, Issue 1No.13Long-term time in target range for body mass index (BMI) and diabetes incidence: insights from CHARLS长期体重指数（BMI）达标时间与糖尿病发病率：来自CHARLS的见解DOI: 10.1038/s41387-025-00404-8
Eur J Nucl Med Mol Imaging IF: 07.600Ahead of Print.No.14Whole-body (18)F-FDG PET/CT identifies subclinical metabolic phenotypes in normoglycemic adults全身(18)F-FDG PET/CT识别正常血糖成人的亚临床代谢表型DOI: 10.1007/s00259-025-07635-y
Journal of robotic surgery IF: 03.000Volume 20, Issue 1No.15Intraoperative pancreatic duct defect extent-guided classification (IPDECT): a novel robotic strategy for benign and low-grade malignant pancreatic tumors术中胰管缺损程度引导分类（IPDECT）：一种用于良性和低度恶性胰腺肿瘤的新型机器人策略DOI: 10.1007/s11701-025-02914-0
Scientific reports IF: 03.900Volume 15, Issue 1No.16Synergistic effects of body fat percentage and C-reactive protein triglyceride-glucose index on cardiovascular disease risk: a Chinese cohort study身体脂肪百分比和C-反应蛋白甘油三酯-葡萄糖指数对心血管疾病风险的协同效应：一项中国队列研究DOI: 10.1038/s41598-025-24094-5
Scientific reports IF: 03.900Volume 15, Issue 1No.17The AST/ALT ratio as a mediator of heavy metal exposure and diabetic kidney disease (DKD) risk: A NHANES studyAST/ALT比率作为重金属暴露与糖尿病肾病风险的中介因子：一项NHANES研究DOI: 10.1038/s41598-025-23843-w
Cell discovery IF: 12.500Volume 11, Issue 1No.18Integrated transcriptome profiling of plasma exosomes reveals molecular stratification of exocrine and endocrine disorders and S100A8-mediated cell interactions in chronic pancreatitis整合血浆外泌体转录组分析揭示慢性胰腺炎中外分泌和内分泌紊乱的分子分层及S100A8介导的细胞相互作用DOI: 10.1038/s41421-025-00832-x
International journal of surgery IF: 10.100Ahead of Print.No.19Association between circulating vitamin D levels and the risk of major endocrine diseases: insights from a longitudinal prospective cohort study循环维生素D水平与主要内分泌疾病风险之间的关联：来自纵向前瞻性队列研究的见解DOI: 10.1097/JS9.0000000000004003
Photodiagnosis Photodyn Ther IF: 02.600Ahead of Print.No.20Observation of Choroidal Blood Flow Parameters in Patients with Diabetic Retinopathy Based on Ultra-Widefield SS-OCTA基于超广角SS-OCTA观察糖尿病视网膜病变患者的脉络膜血流参数DOI: 10.1016/j.pdpdt.2025.105285
Renal failure IF: 03.000Volume 47, Issue 1No.21Associations of hypoglycemic medications, cordycepin and vaccination with clinical outcomes in diabetic kidney disease patients with COVID-19降糖药物、虫草素和疫苗接种与糖尿病肾病患者COVID-19临床结局的关联DOI: 10.1080/0886022X.2025.2584572
Am J Physiol Endocrinol Metab IF: 03.100Ahead of Print.No.22Insulin Resistance and SIK1 Hyperactivation: Implications for Vascular Remodeling in Recurrent Pregnancy Loss胰岛素抵抗与SIK1过度活化：对复发性流产中血管重塑的影响DOI: 10.1152/ajpendo.00515.2024
Frontiers in veterinary science IF: 02.900Volume 12, Issue No.23Quercetin promotes production of secondary hair follicle stem cells in cashmere goat: a mechanistic study槲皮素促进绒山羊次级毛囊干细胞生成：机制研究DOI: 10.3389/fvets.2025.1689059
Patient preference and adherence IF: 02.000Volume 19, Issue No.24Barriers to the Prevention of Insulin Injection-Associated Lipohypertrophy for Individuals with Diabetes糖尿病患者胰岛素注射相关脂肪增生预防的障碍DOI: 10.2147/PPA.S541975
Am J Cancer Res IF: 02.900Volume 15, Issue 10No.25Fluid shear stress-mediated upregulated exosomal-IGF2 promotes hepatocellular carcinoma cell migration and metastasis流体剪切应力介导的上调外泌体-IGF2促进肝细胞癌细胞迁移和转移DOI: 10.62347/OHTF9780
International journal of surgery IF: 10.100Ahead of Print.No.26Preoperative semaglutide before sleeve gastrectomy compared to surgery alone is associated with greater short-term weight loss and dyslipidemia remission: a prospective non-randomized controlled trial袖状胃切除术术前使用司美格鲁肽与单独手术相比，与更显著的短期体重减轻和血脂异常缓解相关：一项前瞻性非随机对照试验DOI: 10.1097/JS9.0000000000004001
ACS omega IF: 04.300Volume 10, Issue 44No.27Photonic Crystal Microarray-Assisted Point-of-Care Testing for Rapid and Convenient Detection of Microalbuminuria光子晶体微阵列辅助的即时检测用于快速方便地检测微量白蛋白尿DOI: 10.1021/acsomega.5c06208
PeerJ IF: 02.400Volume 13, Issue No.28The cuproptosis-related gene ITGB6 and LTBP1 may be associated with diabetic kidney disease progression and immune cell infiltration铜死亡相关基因ITGB6和LTBP1可能与糖尿病肾病进展及免疫细胞浸润相关DOI: 10.7717/peerj.20346
Frontiers in medicine IF: 03.000Volume 12, Issue No.29Construction and validation of a clinical prediction model for diabetic ketoacidosis糖尿病酮症酸中毒临床预测模型的构建与验证DOI: 10.3389/fmed.2025.1638927
Pak J Med Sci IF: 01.700Volume 41, Issue 10No.30Association between red cell distribution width and its ratio with albumin and diabetic nephropathy/retinopathy: A systematic review and meta-analysis红细胞分布宽度及其与白蛋白比值与糖尿病肾病/视网膜病变的关联：一项系统综述和荟萃分析DOI: 10.12669/pjms.41.10.12622
J Diabetes Metab Disord IF: 01.600Volume 24, Issue 2No.31Association between circadian syndrome and periodontitis in U.S. adults: results from NHANES 2009-2014美国成年人中昼夜节律综合征与牙周炎的关联：来自NHANES 2009-2014的结果DOI: 10.1007/s40200-025-01785-4
PloS one IF: 02.600Volume 20, Issue 11No.32Computational identification of novel SIRT4 inhibitors for diabetic nephropathy using pharmacophore modeling, molecular simulations, and DFT calculations基于药效团建模、分子模拟和DFT计算的新型SIRT4抑制剂在糖尿病肾病中的计算识别DOI: 10.1371/journal.pone.0336948
Chronic illness IF: 01.800Ahead of Print.No.33Long COVID and symptom persistence in post-discharge omicron patients: Insights into C-reactive protein长新冠与出院后奥密克戎患者症状持续性：C反应蛋白的启示DOI: 10.1177/17423953251387913
Acta diabetologica IF: 02.900Ahead of Print.No.34METTL14-dependent regulation of HMGB1 attenuates inflammation in diabetic retinopathyMETTL14依赖的HMGB1调控减弱糖尿病视网膜病变中的炎症DOI: 10.1007/s00592-025-02623-y
Invest Ophthalmol Vis Sci IF: 04.700Volume 66, Issue 14No.35Palmitic Acid Induces Ferroptosis in Retinal Microvascular Endothelial Cells by Palmitoylation of Keap1 to Affect Diabetic Retinopathy棕榈酸通过Keap1的棕榈酰化诱导视网膜微血管内皮细胞铁死亡以影响糖尿病视网膜病变DOI: 10.1167/iovs.66.14.41
Curēus IF: 01.300Volume 17, Issue 10No.36Decoding Hypercarotenemia: Integrating Pathophysiology, Clinical Recognition, and Precision Management解码高胡萝卜素血症：整合病理生理学、临床识别与精准管理DOI: 10.7759/cureus.94519
Journal of food science IF: 03.400Volume 90, Issue 11No.37Phosphorylation of Polysaccharides From Lavandula Angustifolia Extracted Using Ultrasound: Characterization, Antioxidant, and Hypoglycemic Activity超声提取的薰衣草多糖磷酸化：表征、抗氧化和降血糖活性DOI: 10.1111/1750-3841.70676
FCVM IF: 02.900Volume 12, Issue No.38A 98 years old super elderly coronary heart disease patient treated with enhanced external counterpulsation: a case report98岁超高龄冠心病患者接受增强型体外反搏治疗：一例报告DOI: 10.3389/fcvm.2025.1616457
Diabetes Metab Syndr Obes IF: 03.000Volume 18, Issue No.39Quantitative CT Assessment of Skeletal Muscle and Abdominal Fat Distribution: Predictive Value for Type 2 Diabetes Mellitus定量CT评估骨骼肌和腹部脂肪分布：对2型糖尿病的预测价值DOI: 10.2147/DMSO.S550824
J Diabetes Metab Disord IF: 01.600Volume 24, Issue 2No.40Ferroptosis-related differentially expressed genes in patients with diabetes糖尿病患者中铁死亡相关的差异表达基因DOI: 10.1007/s40200-025-01740-3
Frontiers in pharmacology IF: 04.800Volume 16, Issue No.41Efficacy and influencing factors analysis of SGLT2 inhibitors in treating heart failure following acute myocardial infarctionSGLT2抑制剂治疗急性心肌梗死后心力衰竭的有效性及影响因素分析DOI: 10.3389/fphar.2025.1693420
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.42The gut-adipose/pancreas axis: a novel perspective on glycolipid metabolism dysregulation in MAFLD and T2DM pathogenesis肠道-脂肪/胰腺轴：MAFLD和T2DM发病机制中糖脂代谢紊乱的新视角DOI: 10.3389/fendo.2025.1664233
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.43Periodontal therapy mitigates inflammation via TNF-α reduction and improves glycolipid metabolism in diabetic patients: a cross-sectional cohort study牙周治疗通过减少TNF-α减轻炎症并改善糖尿病患者糖脂代谢：一项横断面队列研究DOI: 10.3389/fendo.2025.1668695
Frontiers in nutrition IF: 05.100Volume 12, Issue No.44A body composition-based clustering study and its association with metabolic phenotypes among the general population in China基于身体成分的聚类研究及其与中国普通人群代谢表型的关联DOI: 10.3389/fnut.2025.1636849
Nutrition and cancer IF: 02.400Ahead of Print.No.45Letter to the Editor: Revisiting the Impact of Obesity on Cancer-Specific Survival in Rectal Cancer-Clinical and Translational Implications重新审视肥胖对直肠癌癌症特异性生存的影响——临床与转化意义DOI: 10.1080/01635581.2025.2584453
International journal of surgery IF: 10.100Ahead of Print.No.46Comparison of NaPSflex and standard nasal cannula during sedation for gastrointestinal endoscopy in obese patients: a randomized cohort trialNaPSflex与标准鼻导管在肥胖患者胃肠道内窥镜镇静中的比较：一项随机队列试验DOI: 10.1097/JS9.0000000000003903
International journal of surgery IF: 10.100Ahead of Print.No.47Correlation between changes of nutritional parameter changes and alopecia in patients with obesity undergoing laparoscopic sleeve gastrectomy: a prospective cohort study肥胖患者接受腹腔镜袖状胃切除术后营养参数变化与脱发的相关性：一项前瞻性队列研究DOI: 10.1097/JS9.0000000000004004
International journal of surgery IF: 10.100Ahead of Print.No.48Sleeve gastrectomy versus roux-en-Y gastric bypass for remission of type 2 diabetes mellitus and obesity: systematic review and meta-analysis of randomized controlled trials袖状胃切除术与Roux-en-Y胃旁路术用于治疗2型糖尿病合并肥胖：随机对照试验的系统综述和荟萃分析DOI: 10.1097/JS9.0000000000003894
Obesity surgery IF: 03.100Ahead of Print.No.49The Impact of Metabolic Surgery on Infertility: a Bibliometric Analysis of Research Trends and Scientific Contributions代谢手术对不孕症的影响：研究趋势与科学贡献的文献计量分析DOI: 10.1007/s11695-025-08345-y
Nephrol Dial Transplant IF: 05.600Ahead of Print.No.50Trends in nephrology: Cardiovascular Kidney-Metabolic syndrome肾脏病学趋势：心血管-肾脏-代谢综合征DOI: 10.1093/ndt/gfaf250
Frontiers in immunology IF: 05.900Volume 16, Issue No.51Adipose tissue: an inflammatory organ that can not be ignored in periodontal disease related to obesity脂肪组织：在肥胖相关牙周病中不可忽视的炎症器官DOI: 10.3389/fimmu.2025.1698207
Frontiers in public health IF: 03.400Volume 13, Issue No.52Risk identification and improvement strategies for BMI and physical fitness and health grade cross-classification: a cross-sectional study based on Chinese college studentsBMI与体能健康等级交叉分类的风险识别及改进策略：一项基于中国大学生的横断面研究DOI: 10.3389/fpubh.2025.1660686
FCVM IF: 02.900Volume 12, Issue No.53The association between Chinese visceral adiposity index and hypertension among middle-aged and older population: a cross-sectional study based on CHARLS中国内脏脂肪指数与中老年人群高血压的关联：基于CHARLS的横断面研究DOI: 10.3389/fcvm.2025.1664848
Nature and science of sleep IF: 03.400Volume 17, Issue No.54Associations of Sleep-Disordered Breathing and Insomnia with Incident Metabolic Syndrome - The Hispanic Community Health Study/Study of Latinos睡眠呼吸障碍和失眠与新发代谢综合征的关联 - The Hispanic Community Health Study/Study of LatinosDOI: 10.2147/NSS.S546410
Comput Struct Biotechnol J IF: 04.100Volume 27, Issue No.55Metabolic phenotypes: Molecular bridges between health homeostasis and disease imbalance代谢表型：健康稳态与疾病失衡之间的分子桥梁DOI: 10.1016/j.csbj.2025.10.057
Diabetes Metab Syndr Obes IF: 03.000Volume 18, Issue No.56Lean Mass Index, Not Body Mass Index, is Essentially Associated with Arterial Stiffness in Chinese Adults: A Cross-Sectional Study瘦体重指数而非体重指数与中国人动脉僵硬度密切相关：一项横断面研究DOI: 10.2147/DMSO.S556617
Diabetes Metab Syndr Obes IF: 03.000Volume 18, Issue No.57Effect of Lifestyle Intervention on the Mobilization of Fat Depots and Organ Iron Deposition in Individuals with Obesity: A Prospective Study生活方式干预对肥胖个体脂肪库动员和器官铁沉积的影响：一项前瞻性研究DOI: 10.2147/DMSO.S564591
Diabetes Metab Syndr Obes IF: 03.000Volume 18, Issue No.58Can Routine Hematological Markers Improve Obesity Risk Stratification? A Translational Comment on El-Aghbary et al [Letter]常规血液学标志物能否改善肥胖风险分层？对El-Aghbary等人的转化评论DOI: 10.2147/DMSO.S571753
Front Sports Act Living IF: 02.600Volume 7, Issue No.59A lifestyle-based prediction model for obesity in Chinese adolescent students基于生活方式的中国青少年学生肥胖预测模型DOI: 10.3389/fspor.2025.1677707
Frontiers in nutrition IF: 05.100Volume 12, Issue No.60The association between weight-adjusted-waist index and cognitive function: the cross-sectional and longitudinal evidence from CHARLS体重调整腰围指数与认知功能的关联：来自CHARLS的横断面和纵向证据DOI: 10.3389/fnut.2025.1601541
Frontiers in nutrition IF: 05.100Volume 12, Issue No.61Association between obesity indices, insulin resistance markers, and osteoarthritis in middle-aged and elderly Chinese adults肥胖指标、胰岛素抵抗标志物与中国中老年人骨关节炎的关联DOI: 10.3389/fnut.2025.1627421
Food science & nutrition IF: 03.800Volume 13, Issue 11No.62Anti-Obesity Effects Exerted by Achyranthes bidentata Polysaccharides in Diet-Induced Obese Mice牛膝多糖在饮食诱导肥胖小鼠中的抗肥胖作用DOI: 10.1002/fsn3.71185
Frontiers in oncology IF: 03.300Volume 15, Issue No.63Global, regional, and national burden of ovarian cancer attributable to high body mass index, 1990-2021: insights from the global burden of disease study 20211990-2021年高体重指数导致的卵巢癌全球、区域和国家负担：来自2021年全球疾病负担研究的见解DOI: 10.3389/fonc.2025.1568716
ACS omega IF: 04.300Volume 10, Issue 44No.64Computational Screening and Experimental Validation of Natural Compounds that Enhance Butyrate Production in Gut Bacteria and Promote Muscle Cell Mass天然化合物增强肠道细菌丁酸盐生产并促进肌肉细胞质量的计算机筛选与实验验证DOI: 10.1021/acsomega.5c07510
Frontiers in pediatrics IF: 02.000Volume 13, Issue No.65An analysis of the global burden of childhood and adolescent asthma attributable to high BMI: 1990-2021高BMI导致的儿童和青少年哮喘全球负担分析：1990-2021DOI: 10.3389/fped.2025.1646693
PeerJ IF: 02.400Volume 13, Issue No.66The association of maternal pre-pregnancy body mass index with macrosomia: a birth cohort study from China母亲孕前体重指数与巨大儿的关联：一项来自中国的出生队列研究DOI: 10.7717/peerj.20332
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.67Hypothalamic FTO upregulates BDNF to promote GnRH expression through the PI3K/Akt pathway, leading to precocious puberty下丘脑FTO通过PI3K/Akt通路上调BDNF促进GnRH表达导致性早熟DOI: 10.3389/fendo.2025.1665391
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.68PNPLA3-Ile148Met and TM6SF2-Glu167Lys increase susceptibility to metabolic dysfunction-associated steatotic liver disease in childrenPNPLA3-Ile148Met和TM6SF2-Glu167Lys增加儿童代谢功能障碍相关脂肪性肝病的易感性DOI: 10.3389/fendo.2025.1689656
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.69Yerba Maté and its impact on glycemic control and metabolic health: a systematic review and meta-analysis马黛茶对血糖控制和代谢健康的影响：系统评价和荟萃分析DOI: 10.3389/fendo.2025.1641592
Journal of inflammation research IF: 04.100Volume 18, Issue No.70Immune Microenvironmental Differences Between Obese and Healthy People in a High-Altitude Hypoxic Environment高海拔缺氧环境下肥胖与健康人群免疫微环境的差异DOI: 10.2147/JIR.S562386
Frontiers in nutrition IF: 05.100Volume 12, Issue No.71The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio is associated with early onset type 2 diabetes with NAFLD: a cross-sectional study in China非高密度脂蛋白胆固醇与高密度脂蛋白胆固醇比值与早发2型糖尿病合并NAFLD相关：一项中国横断面研究DOI: 10.3389/fnut.2025.1662125
Funct Integr Genomics IF: 03.100Volume 25, Issue 1No.72Epigenetic silencing of MSTN via m6A modification underlies the renoprotective effects of engineered MSC exosomes with RBM15 depletion in diabetic nephropathym6A修饰介导的MSTN表观遗传沉默是RBM15耗竭工程化MSC外泌体在糖尿病肾病中肾保护作用的基础DOI: 10.1007/s10142-025-01746-3
Frontiers in pharmacology IF: 04.800Volume 16, Issue No.73Agonizing GABA(B)R suppresses GLP-1RA's chronotropic effect and reduces post-myocardial infarction arrhythmogenesis激动GABA(B)R抑制GLP-1RA变时效应并减少心肌梗死后心律失常发生DOI: 10.3389/fphar.2025.1616181
Annals of medicine IF: 04.300Volume 57, Issue 1No.74C-reactive protein-triglyceride glucose index in predicting three-vessel coronary artery disease risk: a retrospective study using machine learning approachesC反应蛋白-甘油三酯葡萄糖指数预测三支冠状动脉疾病风险：一项基于机器学习方法的回顾性研究DOI: 10.1080/07853890.2025.2584308
QJM IF: 06.400Ahead of Print.No.75Lifestyles, Metabolome, and Diabetic Kidney Disease: A Cohort Study生活方式、代谢组与糖尿病肾病：一项队列研究DOI: 10.1093/qjmed/hcaf281
The FASEB journal : IF: 04.200Volume 39, Issue 22No.76Liraglutide Mitigates Renal Injury in Diabetic Kidney Disease by Suppressing Podocyte Cholesterol Accumulation Through mTOR/VMP1-Regulated Autophagy利拉鲁肽通过mTOR/VMP1调节的自噬抑制足细胞胆固醇积累减轻糖尿病肾病肾损伤DOI: 10.1096/fj.202502041RRR
Pulse IF: 07.300Volume 13, Issue 1No.77Comparison between Triglyceride Glucose Index and Homeostasis Model Assessment of Insulin Resistance in Their Associations with Vascular Dysfunction: Danyang Study甘油三酯葡萄糖指数与稳态模型评估胰岛素抵抗在血管功能障碍关联中的比较：Danyang StudyDOI: 10.1159/000548848
JGH open : IF: 01.500Volume 9, Issue 11No.78A Clinical Analysis of the Association Between Nifedipine and Insulin Usage and the Increased Incidence of Colonic Polyps硝苯地平和胰岛素使用与结肠息肉发病率增加关联的临床分析DOI: 10.1002/jgh3.70269
J Asian Nat Prod Res IF: 01.300Ahead of Print.No.79Rutin inhibits hepatic gluconeogenesis and increases glycogen synthesis through the IRS/PI3K/akt signaling pathway in insulin resistant hepatocytes芦丁通过IRS/PI3K/Akt信号通路抑制胰岛素抵抗肝细胞的肝糖异生并增加糖原合成DOI: 10.1080/10286020.2025.2577900
Anatol J Cardiol IF: 01.500Ahead of Print.No.80Triglyceride-Glucose Index and the Risk of Calcific Aortic Valve Stenosis: A Bidirectional Mendelian Randomization Study甘油三酯-葡萄糖指数与钙化性主动脉瓣狭窄风险：一项双向孟德尔随机化研究DOI: 10.14744/AnatolJCardiol.2025.5649
Annals of medicine IF: 04.300Volume 57, Issue 1No.81Clinical characteristics of tracheobronchial mucormycosis: a retrospective analysis of twenty cases气管支气管毛霉菌病的临床特征：二十例回顾性分析DOI: 10.1080/07853890.2025.2584286
Food & function IF: 05.400Ahead of Print.No.82Morinda citrifolia L. (noni) and its potential in the management of systemic metabolic disorder (SMD)Morinda citrifolia L. (noni) 及其在系统性代谢紊乱（SMD）管理中的潜力DOI: 10.1039/d5fo03892h
Medical science monitor IF: 02.100Volume 31, Issue No.83Association of Hyperuricemia with Cardiovascular Risk Factors and Cardiac Structural Changes in Patients Undergoing Maintenance Hemodialysis in Southwest China中国西南部维持性血液透析患者高尿酸血症与心血管危险因素及心脏结构变化的关联DOI: 10.12659/MSM.949422
Diabetes & metabolism journal IF: 08.500Volume 49, Issue 6No.84Sex Differences in Albuminuria Risk with Metformin Use: Insights from a Cross-Sectional Study and Drug-Target Mendelian Randomization Analysis二甲双胍使用中白蛋白尿风险的性别差异：基于横断面研究和药物靶点孟德尔随机化分析的见解DOI: 10.4093/dmj.2025.0664
Int J Gynaecol Obstet IF: 02.400Ahead of Print.No.85A case of intrauterine fetal death due to spontaneous rupture of the umbilical artery脐动脉自发性破裂致宫内胎儿死亡一例DOI: 10.1002/ijgo.70647
Anatol J Cardiol IF: 01.500Ahead of Print.No.86Sarcopenic Obesity and Cardiovascular Disease Risk and Mortality: A Systematic Review and Meta-Analysis肌肉减少性肥胖与心血管疾病风险和死亡率的系统综述和荟萃分析DOI: 10.14744/AnatolJCardiol.2025.5635
Anatol J Cardiol IF: 01.500Ahead of Print.No.87PCSK9 Inhibition Protects Against Myocardial Ischemia-Reperfusion Injury in Type 2 Diabetes Rats Via Suppressing Inflammation and ApoptosisPCSK9抑制通过抑制炎症和凋亡保护2型糖尿病大鼠心肌缺血再灌注损伤DOI: 10.14744/AnatolJCardiol.2025.5523
CNS neuroscience & therapeutics IF: 05.000Volume 31, Issue 11No.88Dialogue Between the Clock Gene Bmal1 and Retinopathy: What Is the Exact Relationship?时钟基因Bmal1与视网膜病变之间的对话：确切关系是什么DOI: 10.1111/cns.70490
Annals of medicine IF: 04.300Volume 57, Issue 1No.89Association between triglyceride-glucose index upon admission and the subsequent occurrence of acute kidney injury in adult patients with diabetic ketoacidosis: a single-center retrospective cohort study入院时甘油三酯-葡萄糖指数与成人糖尿病酮症酸中毒患者随后发生急性肾损伤的关联：一项单中心回顾性队列研究DOI: 10.1080/07853890.2025.2588005
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.90Nomogram-based prediction of hypoglycemia risk in elderly community-dwelling patients with type 2 diabetes: Development and validation in a multicentre real-world cohort基于列线图的2型糖尿病老年社区居住患者低血糖风险预测：在多中心真实世界队列中的开发和验证DOI: 10.1111/dom.70297
Clin Pharmacol Ther IF: 05.500Ahead of Print.No.91Advances in Incretin-Based Therapies for MAFLD: Mechanisms and Clinical Evidence基于肠促胰岛素的疗法在MAFLD中的进展：机制与临床证据DOI: 10.1002/cpt.70131
Endocrinology and metabolism IF: 04.200Ahead of Print.No.92Joint Associations of the Geriatric Nutrition Risk Index and Frailty with All-Cause and Cause-Specific Mortality in Diabetes Patients: A Prospective Cohort Study老年营养风险指数和衰弱与糖尿病患者全因及病因特异性死亡率的联合关联：一项前瞻性队列研究DOI: 10.3803/EnM.2025.2441
J Cachexia Sarcopenia Muscle IF: 09.100Volume 16, Issue 6No.933D Body Scanning-Derived Normative Values of Appendicular Circumferences: A Novel Tool for Sarcopenia Screening in Chinese Adults三维身体扫描衍生的肢体周长参考值：一种用于中国成年人肌肉减少症筛查的新工具DOI: 10.1002/jcsm.70135
Advanced science IF: 14.100Ahead of Print.No.94CARD9 Conveys Pancreatic Islet Sympathetic Nervous β2 Signals to Reshape Macrophage Creatine Metabolism in Type 1 DiabetesCARD9介导胰腺胰岛交感神经β2信号传导重塑1型糖尿病巨噬细胞肌酸代谢DOI: 10.1002/advs.202507543
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BMJ Open Diabetes Res Care IF: 04.100Volume 13, Issue 6No.26Text messaging interventions are associated with reductions in HbA1c among patients with diabetes: a systematic review and meta-analysis短信干预与糖尿病患者HbA1c降低相关：一项系统回顾和荟萃分析DOI: 10.1136/bmjdrc-2025-005218
BMJ Global Health IF: 06.100Volume 10, Issue 11No.27Embedding equity and diversity principles in a complex multinational setting: methods, tools, capacity development and experiences from the first year of the Joint Action on Cardiovascular Diseases and Diabetes (JACARDI)在复杂多国环境中嵌入公平与多样性原则：心血管疾病与糖尿病联合行动(JACARDI)第一年的方法、工具、能力发展与经验DOI: 10.1136/bmjgh-2025-019829
J Child Adolesc Psychopharmacol IF: 02.200Ahead of Print.No.28How Much Is Too Much? Escalating Psychotropic Class Polypharmacy, Diabetes Risk, and Clinical Complexity in Stimulant New Users多少算太多？兴奋剂新用户中升级的精神药物类别多药联用、糖尿病风险与临床复杂性DOI: 10.1177/10445463251399806
Int J Pharm IF: 05.200Ahead of Print.No.29Additive manufacturing of microneedles: a quality by design approach to clinical translation增材制造微针：基于质量源于设计方法的临床转化DOI: 10.1016/j.ijpharm.2025.126399
Hormone and metabolic research IF: 01.800Ahead of Print.No.30Proteomic Signatures and Blood Adenosine Triphosphate Levels as Markers of Empagliflozin Efficacy in Type 2 Diabetes Mellitus and Heart Failure蛋白质组学特征和血液腺苷三磷酸水平作为恩格列净在2型糖尿病和心力衰竭中有效性的标志物DOI: 10.1055/a-2716-7109
Cardiovascular Research IF: 13.300Ahead of Print.No.31Transcriptional readthrough at Atf4 locus suppresses Rps19bp1 and impairs heart developmentAtf4位点的转录通读抑制Rps19bp1并损害心脏发育DOI: 10.1093/cvr/cvaf237
Molecular metabolism IF: 06.600Ahead of Print.No.32REGULATION OF HDL DYSFUNCTIONALITY BY PHOSPHATIDYLETHANOLAMINE LINKS POLY-UNSATURATED FATTY ACIDS WITH ATHEROSCLEROTIC CARDIOVASCULAR DISEASES磷脂酰乙醇胺调节HDL功能障碍将多不饱和脂肪酸与动脉粥样硬化性心血管疾病联系起来DOI: 10.1016/j.molmet.2025.102281
Kobe J Med SciVolume 71, Issue 3No.33Apolipoprotein B48 as a Marker of Residual Coronary Risk: Diagnostic Insights from a Comparative Analysis with Ankle-Brachial Index载脂蛋白B48作为残余冠状动脉风险的标志物：与踝臂指数的比较分析诊断见解DOI: 10.24546/0100497875
Nature medicine IF: 50.000Ahead of Print.No.34Brain activity associated with breakthrough food preoccupation in an individual on tirzepatide大脑活动与替尔泊肽治疗个体中突破性食物沉迷相关DOI: 10.1038/s41591-025-04035-5
Scientific reports IF: 03.900Volume 15, Issue 1No.35A COM-B-guided lifestyle intervention reduces metabolic syndrome in overweight and obese adolescents: a multiphase study in Vietnam基于COM-B模型的生活方式干预减少越南超重和肥胖青少年的代谢综合征：一项多阶段研究DOI: 10.1038/s41598-025-24085-6
Zhongguo Ying Yong Sheng Li Xue Za ZhiVolume 41, Issue No.36Aprocitentan in Resistant Hypertension: Mechanistic Insights, Clinical Evidence, and Future DirectionsAprocitentan 在抵抗性高血压中的应用：机制见解、临床证据与未来方向DOI: 10.62958/j.cjap.2025.030
Diab Vasc Dis Res IF: 03.000Volume 22, Issue 6No.37Unusual painless upper limb ischemia in a patient with diabetes. A case study糖尿病患者中罕见的无痛性上肢缺血：一例研究DOI: 10.1177/14791641251380498
Discover Oncology IF: 02.900Volume 16, Issue 1No.38SGLT2 inhibitors and their role in reducing mortality among cancer patients with type 2 diabetes undergoing immune checkpoint inhibitor therapySGLT2抑制剂及其在降低接受免疫检查点抑制剂治疗的2型糖尿病癌症患者死亡率中的作用DOI: 10.1007/s12672-025-04046-1
JACC IF: 22.300Volume 86, Issue 21, Page 1981-2101No.39Remnant Cholesterol and Cardiovascular Risk in Young Adults: Moving Beyond Low-Density Lipoprotein Cholesterol残余胆固醇与年轻成人心血管风险：超越低密度脂蛋白胆固醇DOI: 10.1016/j.jacc.2025.08.097
Open veterinary journal IF: 01.000Volume 15, Issue 10No.40Successful treatment with recombinant human GH in a kitten with suspected congenital hyposomatotropism用重组人生长激素成功治疗疑似先天性生长激素缺乏症的小猫DOI: 10.5455/OVJ.2025.v15.i10.59
Journal of diabetes research IF: 03.400Volume 2025, Issue No.41Impact of a Nurse Practitioner-Led Diabetes Program on Barriers to CGM Use in a Federally Qualified Health Center After Medicaid Expansion护士执业医师主导的糖尿病项目对医疗补助扩展后联邦合格健康中心中CGM使用障碍的影响DOI: 10.1155/jdr/5724236
Touch reviews in endocrinologyVolume 21, Issue 2No.42Advancing the Therapeutic Frontier in Thyroid Eye Disease甲状腺眼病治疗前沿进展DOI: 10.17925/EE.2025.21.2.2
J Clin Transl Endocrinol IF: 03.300Volume 42, Issue No.43Insights into intramuscular adipose-muscle signaling in the diabetic lower extremity糖尿病下肢肌内脂肪-肌肉信号传导的见解DOI: 10.1016/j.jcte.2025.100422
J Clin Exp Hepatol IF: 03.200Volume 16, Issue 1No.44Time Restricted Hypo-caloric Diet Achieves Better Insulin Sensitivity over Hypo-caloric Diet Alone in Patients With Metabolic Dysfunction-associated Steatotic Liver Disease: A Randomized Controlled Trial时间限制性低热量饮食在代谢功能障碍相关脂肪性肝病患者中比单纯低热量饮食更能改善胰岛素敏感性：一项随机对照试验DOI: 10.1016/j.jceh.2025.103198
Frontiers in pediatrics IF: 02.000Volume 13, Issue No.45Long term endocrine issues in adults born prematurely: a systematic review早产儿成年后长期内分泌问题：一项系统回顾DOI: 10.3389/fped.2025.1646976
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.46Deciphering the epigenetic role of KDM4A in pancreatic β-like cell differentiation from iPSCs解读KDM4A在iPSCs来源胰腺β样细胞分化中的表观遗传作用DOI: 10.3389/fendo.2025.1697097
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.47Nutrition therapy in the era of automated insulin delivery自动化胰岛素输送时代的营养疗法DOI: 10.3389/fendo.2025.1690486
Front Clin Diabetes Healthc IF: 02.200Volume 6, Issue No.48Ferroptosis and pyroptosis in diabetes mellitus: emerging therapeutic potential of GLP-1 receptor agonists铁死亡和细胞焦亡在糖尿病中的作用：GLP-1受体激动剂的新兴治疗潜力DOI: 10.3389/fcdhc.2025.1657710
Pak J Med Sci IF: 01.700Volume 41, Issue 10No.49Ultra-Widefield Fluorescein Angiography-Based Targeted Retinal Photocoagulation versus Panretinal Photocoagulation in Proliferative Diabetic Retinopathy: A Randomized Controlled Trial基于超广角荧光素血管造影的靶向视网膜光凝与全视网膜光凝在增殖性糖尿病视网膜病变中的比较：一项随机对照试验DOI: 10.12669/pjms.41.10.12535
Frontiers in nutrition IF: 05.100Volume 12, Issue No.50Body composition as a complementary tool for detection of metabolic syndrome 6 years postpartum: a St. Carlos Cohort follow-up体成分作为产后6年代谢综合征检测的补充工具：圣卡洛斯队列随访研究DOI: 10.3389/fnut.2025.1689658
Pak J Med Sci IF: 01.700Volume 41, Issue 10No.51The Effect of spinal anesthesia on sensory and motor block in cesarean cases with a diagnosis of gestational diabetes mellitus脊髓麻醉对诊断为妊娠期糖尿病的剖宫产病例中感觉和运动阻滞的影响DOI: 10.12669/pjms.41.10.12138
Clinical interventions in aging IF: 03.700Volume 20, Issue No.52Balance and Gait Disorders in the Aged Population. Causes, Assessment and Management: A Literature Review老年人群平衡与步态障碍：原因、评估与管理——文献综述DOI: 10.2147/CIA.S531235
BMJ open IF: 02.300Volume 15, Issue 11No.53Move to improve: protocol for a single-arm, pragmatic feasibility trial of an individualised physical activity programme for children with chronic conditionsMove to Improve：针对慢性病儿童个体化体力活动方案的单臂、实用性可行性试验方案DOI: 10.1136/bmjopen-2025-101909
BMJ open IF: 02.300Volume 15, Issue 11No.54Burden and predictors of age-related macular degeneration among old age patients with diabetes attending comprehensive specialised hospitals in Northwest Ethiopia: a multicentre cross-sectional prospective study埃塞俄比亚西北部综合性专科医院老年糖尿病患者中年龄相关性黄斑变性的负担和预测因素：一项多中心横断面前瞻性研究DOI: 10.1136/bmjopen-2025-105305
BMJ open IF: 02.300Volume 15, Issue 11No.55Progression in adult patients with early-stage chronic kidney disease attending tertiary hospitals in Dodoma, Tanzania: prospective longitudinal study坦桑尼亚Dodoma三级医院成人早期慢性肾脏病患者的进展：前瞻性纵向研究DOI: 10.1136/bmjopen-2024-094121
BMJ open IF: 02.300Volume 15, Issue 11No.56Health risk behaviours, mental health and HbA1c: an overview of reviews of observational studies健康风险行为、心理健康与糖化血红蛋白：观察性研究综述的概述DOI: 10.1136/bmjopen-2024-092657
Proc Natl Acad Sci U S A IF: 09.100Volume 122, Issue 47No.57Rac1 promotes proximal tubule kidney repair by coupling the actin cytoskeleton to mitochondrial functionRac1通过耦合肌动蛋白细胞骨架与线粒体功能促进近端小管肾脏修复DOI: 10.1073/pnas.2504565122
Retina IF: 02.100Ahead of Print.No.58DRSplus retinographer in patients with diabetes: a comparison study by consensus grading, Reading Center and Artificial IntelligenceDRSplus视网膜成像仪在糖尿病患者中的应用：基于共识分级、阅读中心和人工智能的比较研究DOI: 10.1097/IAE.0000000000004734
Hospital practiceAhead of Print.No.59Navigating collaboration in complex care: perspectives from general practitioners, hospital specialists, and patients - a qualitative study复杂护理中的协作导航：来自全科医生、医院专科医生和患者的视角——一项定性研究DOI: 10.1080/21548331.2025.2586449
PloS one IF: 02.600Volume 20, Issue 11No.60Sociodemographic intersections and risk of multiple long-term conditions: A systematic review社会人口学交叉与多长期疾病风险：一项系统综述DOI: 10.1371/journal.pone.0336958
International journal of surgery IF: 10.100Ahead of Print.No.61Predictors of readmission after esophagectomy for esophageal cancer: a systematic review and meta-analysis食管癌食管切除术后再次入院的预测因素：一项系统回顾和荟萃分析DOI: 10.1097/JS9.0000000000003860
International journal of surgery IF: 10.100Ahead of Print.No.62Intelligent evaluation system for anticoagulant and antiplatelet therapy in surgical patients手术患者抗凝与抗血小板治疗的智能评估系统DOI: 10.1097/JS9.0000000000003980
Indian Journal of Public Health IF: 00.900Ahead of Print.No.63Effect of Dietary and Physical Activity Counseling on Blood Glucose Level of Pregnant Women with Gestational Diabetes Mellitus Attending a Tertiary Care Hospital in Lucknow - A Quasi-experimental Study饮食和体力活动咨询对勒克瑙一家三级医院就诊的妊娠期糖尿病孕妇血糖水平的影响 - 一项准实验研究DOI: 10.4103/ijph.ijph_82_24
Am J Physiol Endocrinol Metab IF: 03.100Ahead of Print.No.64Assessing the Rate-Dependence of the First Phase of Glucose-Stimulated Insulin Secretion: Dynamic Perifusion Studies with Isolated Human Pancreatic Islets评估葡萄糖刺激胰岛素分泌第一阶段的速率依赖性：使用分离人胰岛的动态灌注研究DOI: 10.1152/ajpendo.00307.2025
Eur J Cancer Prev IF: 02.500Ahead of Print.No.65Pancreatic findings in participants in a program of low-dose computed tomography screening for lung cancer肺癌低剂量计算机断层扫描筛查项目中参与者的胰腺发现DOI: 10.1097/CEJ.0000000000000997
Journal of gastroenterology IF: 05.500Ahead of Print.No.66TRPV6-related pancreatitis: natural history and the impact of the pancreas-specific deletion on pancreatitis in miceTRPV6相关胰腺炎：自然史及胰腺特异性缺失对小鼠胰腺炎的影响DOI: 10.1007/s00535-025-02323-y
Diabetologia IF: 10.200Ahead of Print.No.67The virtual Morris water maze for cognitive function assessment in adolescents with type 1 diabetes虚拟莫里斯水迷宫用于1型糖尿病青少年认知功能评估DOI: 10.1007/s00125-025-06598-x
Diabetologia IF: 10.200Ahead of Print.No.68Diverse combination of factors associated with the development of diabetic kidney disease among data-driven diabetes subtypes: analysis of the J-DREAMS registry数据驱动糖尿病亚型中与糖尿病肾病发展相关的多种因素组合：J-DREAMS注册研究分析DOI: 10.1007/s00125-025-06594-1
Rev Esp Enferm Dig IF: 04.000Ahead of Print.No.69The implementation of PCR-guided therapy in the eradication of Helicobacter pylori: experience from the European Registry on H. pylori management (Hp-EuReg)PCR指导治疗在根除幽门螺杆菌中的应用：来自欧洲幽门螺杆菌管理注册中心(Hp-EuReg)的经验DOI: 10.17235/reed.2025.11699/2025
Drug Metab Pers TherAhead of Print.No.70Neural network modelling of experimental diabetes to study new antidiabetic drugs神经网络建模在实验性糖尿病中研究新型抗糖尿病药物DOI: 10.1515/dmpt-2025-0049
J Clin Endocrinol Metab IF: 05.100Ahead of Print.No.71Response to Letter to the Editor from Mou and Tian: "Central Precocious Puberty in Males, GnRHa-Treated or Untreated, Did Not Impact Fertility and Health in Mid-Adulthood"对Mou和Tian编辑来信的回应：男性中枢性性早熟，GnRHa治疗或未治疗，未影响中年生育与健康DOI: 10.1210/clinem/dgaf561
Rheumatology IF: 04.400Ahead of Print.No.72Effects of systemic TNF inhibition on postprandial glucose-regulatory hormones in inflammatory arthritis系统TNF抑制对炎性关节炎中餐后血糖调节激素的影响DOI: 10.1093/rheumatology/keaf601
Chemical communications IF: 04.200Ahead of Print.No.73Amino acid-modified G-quartet hydrogel for glucose-responsive insulin release in vivo氨基酸修饰的G-四链体水凝胶用于体内葡萄糖响应性胰岛素释放DOI: 10.1039/d5cc05351j
J Diabetes Sci Technol IF: 03.700Ahead of Print.No.74Beyond Time in Range: Hidden Statistical Challenges of Continuous Glucose Monitoring Data in Diabetes Drug Development超越时间在范围：连续葡萄糖监测数据在糖尿病药物研发中的隐藏统计挑战DOI: 10.1177/19322968251394046
The FASEB journal : IF: 04.200Volume 39, Issue 22No.75Central Osmolality Sensing for Arginine Vasopressin Release Is Mediated by WNK1-OSR1/SPAK-Kv3.1 Cascade中枢渗透压感知精氨酸加压素释放由WNK1-OSR1/SPAK-Kv3.1级联介导DOI: 10.1096/fj.202502072RR
Sci Diabetes Self Manag Care IF: 02.200Ahead of Print.No.76Clinician, Youth, and Parent Perspectives on Diabetes Technology Education临床医生、青少年及家长对糖尿病技术教育的观点DOI: 10.1177/26350106251383865
Curēus IF: 01.300Volume 17, Issue 10No.77Beyond the Break: Radiologic Diagnosis and Outcomes of Necrotizing Fasciitis Complicating Orthopedic Fractures骨折之外：坏死性筋膜炎并发症骨科骨折的影像学诊断与结局DOI: 10.7759/cureus.94721
Curēus IF: 01.300Volume 17, Issue 10No.78Comparing Artificial Intelligence and Obstetrics Residents in Answering Standardized Patient Questions Regarding Gestational Diabetes比较人工智能与产科住院医师在回答标准化患者关于妊娠期糖尿病问题上的表现DOI: 10.7759/cureus.94662
Curēus IF: 01.300Volume 17, Issue 10No.79Non-resolving, Progressive, Non-ketotic Hyperglycemic Hemichorea-Hemiballismus Syndrome in an Elderly Male老年男性非缓解性进行性非酮症高血糖性偏侧舞蹈症-偏侧投掷症综合征DOI: 10.7759/cureus.94603
Curēus IF: 01.300Volume 17, Issue 10No.80Coronary Angiographic Profile and Incidence of Coronary Artery Disease in Patients Undergoing Permanent Pacemaker Implantation for Conduction Abnormalities接受永久性起搏器植入术治疗传导异常患者的冠状动脉造影特征及冠心病发病率DOI: 10.7759/cureus.94518
Curēus IF: 01.300Volume 17, Issue 10No.81Temporal and Regional Trends in the Crude Prevalence of Diabetes in Canada From 2000 to 2022: An Ecological Study Using Aggregated Surveillance Data2000年至2022年加拿大糖尿病粗患病率的时间与区域趋势：一项基于聚合监测数据的生态学研究DOI: 10.7759/cureus.94556
Curēus IF: 01.300Volume 17, Issue 10No.82Bezold's Abscess Secondary to a Subclinical Mastoid Infection: Diagnostic Challenges and Literature Review贝佐尔德脓肿继发于亚临床乳突感染：诊断挑战与文献回顾DOI: 10.7759/cureus.94544
Curēus IF: 01.300Volume 17, Issue 10No.83Use of Continuous Glucose Monitoring in Non-diabetic Individuals for Cardiovascular Prevention: A Systematic Review of Its Impact on Guiding Lifestyle Interventions连续葡萄糖监测在非糖尿病人群心血管预防中的应用：对其指导生活方式干预影响的系统综述DOI: 10.7759/cureus.94460
Curēus IF: 01.300Volume 17, Issue 10No.84The Impact of Conservative Versus Pharmacological Management on Maternal and Neonatal Outcomes in Gestational Diabetes: A Systematic Review and Meta-Analysis保守治疗与药物治疗对妊娠期糖尿病母婴结局的影响：一项系统回顾和荟萃分析DOI: 10.7759/cureus.94610
World J Emerg Med IF: 03.200Volume 16, Issue 6No.85BRASH syndrome: a systematic review of clinical manifestations and associated risk factorsBRASH综合征：临床表现及相关风险因素的系统综述DOI: 10.5847/wjem.j.1920-8642.2025.107
Frontiers in immunology IF: 05.900Volume 16, Issue No.86Editorial: Autoimmunity: novel insights and future perspectives社论：自身免疫：新见解与未来展望DOI: 10.3389/fimmu.2025.1728233
Frontiers in immunology IF: 05.900Volume 16, Issue No.87The complement pathway and the pathophysiology of fibroproliferative cutaneous scarring补体通路与纤维增生性皮肤疤痕的病理生理学DOI: 10.3389/fimmu.2025.1701998
BMJ open IF: 02.300Volume 15, Issue 11No.88Prognostic impact of heart failure, chronic kidney disease and atherosclerotic disease alone or combined in an elderly population: a retrospective cohort study based on electronic health record data心力衰竭、慢性肾脏病和动脉粥样硬化性疾病单独或组合在老年人群中的预后影响：一项基于电子健康记录数据的回顾性队列研究DOI: 10.1136/bmjopen-2024-094853
Clinical epidemiology IF: 03.200Volume 17, Issue No.89Leveraging a Bayesian Approach in a Comparative Effectiveness Trial of Major Adverse Cardiovascular Events在主要不良心血管事件比较效果试验中应用贝叶斯方法DOI: 10.2147/CLEP.S540048
The Pan African medical journal IF: 01.000Volume 52, Issue No.90Acute drug intoxication: predictive factors for hospitalization急性药物中毒：住院的预测因素DOI: 10.11604/pamj.2025.52.23.47923
Journal of diabetes research IF: 03.400Volume 2025, Issue No.91A Qualitative Analysis of Provider-Level Barriers to Prescribing Diabetes Technology糖尿病技术处方提供者层面障碍的定性分析DOI: 10.1155/jdr/8873848
PeerJ IF: 02.400Volume 13, Issue No.92Assessment of distinct effects of Parinari curatellifolia Planch.ex Benth Ethanolic leaf extract on glucose transport in different cell types评估Parinari curatellifolia Planch.ex Benth乙醇叶提取物在不同细胞类型中对葡萄糖转运的独特影响DOI: 10.7717/peerj.20269
Frontiers in public health IF: 03.400Volume 13, Issue No.93Early risk detection of metabolic syndrome using sex-specific machine learning models in military personnel基于性别特异性机器学习模型的军事人员代谢综合征早期风险检测DOI: 10.3389/fpubh.2025.1625461
JMIR IF: 06.000Volume 27, Issue No.94Effects of a Digital Health Intervention for Adults With Type 2 Diabetes Mellitus on Health Care Resource Use and Health Care Charges in the United States: Retrospective Cohort Study数字健康干预对美国成人2型糖尿病患者医疗资源使用和医疗费用的影响：一项回顾性队列研究DOI: 10.2196/67320
BMJ open IF: 02.300Volume 15, Issue 11No.95Effect of the FoodSwitch application on type 2 diabetes in Sweden: a study protocol for the randomised controlled DIgitAl diabeTES Treatment - the Healthy Eating, heaLthy Patients trial (DIATEST-HELP)FoodSwitch应用程序对瑞典2型糖尿病的影响：随机对照数字糖尿病治疗-健康饮食、健康患者试验（DIATEST-HELP）的研究方案DOI: 10.1136/bmjopen-2025-110141
BMJ open IF: 02.300Volume 15, Issue 11No.96Prevalence, determinants and consequences of delayed treatment intensification among type 2 diabetes mellitus patients at the University of Gondar Comprehensive Specialised Hospital, Northwest Ethiopia, 2024: a mixed-methods study埃塞俄比亚西北部贡德尔大学综合专科医院2型糖尿病患者延迟治疗强化的患病率、决定因素及后果：一项混合方法研究DOI: 10.1136/bmjopen-2025-105455
BMJ open IF: 02.300Volume 15, Issue 11No.97Enablers and barriers of e-learning utilising smart technologies in type 2 diabetes care for clinicians: a systematic review2型糖尿病护理中智能技术电子学习的促进因素与障碍：一项系统评价DOI: 10.1136/bmjopen-2025-103328
Curēus IF: 01.300Volume 17, Issue 10No.98Widespread Progressive Telangiectasia in a 54-Year-Old Caucasian Male54岁白人男性广泛性进行性毛细血管扩张症DOI: 10.7759/cureus.94588
Curēus IF: 01.300Volume 17, Issue 10No.99A Multidisciplinary Approach to Silent Ischaemic Strokes Unveiling Primary CNS Vasculitis: Exploring Beyond the Apparent多学科方法揭示原发性CNS血管炎：探索无声缺血性卒中的表象之外DOI: 10.7759/cureus.94547
Curēus IF: 01.300Volume 17, Issue 10No.100Role of Trace Elements in Diabetic Retinopathy: A Systematic Review微量元素在糖尿病视网膜病变中的作用：一项系统综述DOI: 10.7759/cureus.94461
Curēus IF: 01.300Volume 17, Issue 10No.101Cardiovascular Outcomes of SGLT-2 Inhibitors in Hypertensive Patients With and Without Diabetes: A Retrospective Observational StudySGLT-2抑制剂在高血压患者（有和没有糖尿病）中的心血管结局：一项回顾性观察研究DOI: 10.7759/cureus.94467
Curēus IF: 01.300Volume 17, Issue 10No.102The Impact of Lipaemia on the Laboratory Results in a Patient With Diabetes脂血症对糖尿病患者实验室结果的影响DOI: 10.7759/cureus.94402
Curēus IF: 01.300Volume 17, Issue 10No.103Treatment Adherence and Its Determinants in the Geriatric Population With Non-communicable Diseases Living in Urban Slums of Pune: An Analytical Cross-Sectional Study浦那城市贫民窟老年非传染性疾病患者治疗依从性及其决定因素：一项分析性横断面研究DOI: 10.7759/cureus.94645
Journal of diabetes research IF: 03.400Volume 2025, Issue No.104Mechanisms and Pathways Linking Depression and Type 2 Diabetes Outcomes: A Scoping Review抑郁症与2型糖尿病结局关联的机制与路径：范围综述DOI: 10.1155/jdr/5590413
Korean J Community NutrVolume 30, Issue 5No.105Sex differences in the association between Korean Healthy Eating Index and type 2 diabetes mellitus in Korean adults: a prospective cohort study韩国成年人中韩国健康饮食指数与2型糖尿病关联的性别差异：一项前瞻性队列研究DOI: 10.5720/kjcn.2025.00227
J Diabetes Metab Disord IF: 01.600Volume 24, Issue 2No.106Association of CYP2C9, CYP2C19, CYP2C8, CYP2A6, and CYP3A4 gene polymorphism with drug response in an Indian cohort of patients with type 2 diabetes mellitusCYP2C9、CYP2C19、CYP2C8、CYP2A6和CYP3A4基因多态性与印度2型糖尿病患者队列中药物反应的关联DOI: 10.1007/s40200-025-01762-x
Tropical life sciences research IF: 01.100Volume 36, Issue 2No.107Antihyperglycaemic Activity of Standardised Ethanolic Extract of Swietenia macrophylla King Seeds on Goto-Kakizaki Type 2 Diabetic Rats标准化的Swietenia macrophylla King种子乙醇提取物在Goto-Kakizaki 2型糖尿病大鼠中的抗高血糖活性DOI: 10.21315/tlsr2025.36.2.5
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.108Genetic/epigenetic RNA dysregulation in type 2 diabetes mellitus complicated with ischemic heart disease2型糖尿病并发缺血性心脏病中的遗传/表观遗传RNA失调DOI: 10.3389/fendo.2025.1687145
IF: 00.700Volume 35, Issue 11No.109Clinical Utility of Multiplex PCR for Managing Community-Acquired Pneumonia in Diabetic and Non-Diabetic Patients多重PCR在管理糖尿病与非糖尿病患者社区获得性肺炎中的临床效用DOI: 10.29271/jcpsp.2025.11.1466
Pain reports IF: 03.100Volume 10, Issue 6No.110Chronic pain and mortality risk among middle-age and older Japanese: the Shika town cohort study日本中老年人慢性疼痛与死亡风险：志贺町队列研究DOI: 10.1097/PR9.0000000000001361
Hormone research in p?diatrics : IF: 02.700Ahead of Print.No.111T1Drink: Education gaps and safety issues concerning alcohol consumption in young adults with type 1 diabetes mellitus - A JENIOUS-driven international Initiative reportT1Drink：1型糖尿病年轻成人饮酒的教育差距与安全问题——JENIOUS驱动的国际倡议报告DOI: 10.1159/000549602
Muscle & nerve IF: 03.100Ahead of Print.No.112Corneal Immune Cells and Their Relation to Diabetic Peripheral Neuropathy and Neuropathic Pain角膜免疫细胞及其与糖尿病周围神经病变和神经性疼痛的关系DOI: 10.1002/mus.70061
Curēus IF: 01.300Volume 17, Issue 10No.113Atezolizumab-Induced Thyroiditis and Immune Checkpoint Inhibitor (ICI)-Type 1 Diabetes Mellitus: Diagnostic and Therapeutic Challenges in ICI-Associated EndocrinopathiesAtezolizumab诱导的甲状腺炎和免疫检查点抑制剂（ICI）相关1型糖尿病：ICI相关内分泌疾病的诊断与治疗挑战DOI: 10.7759/cureus.94593
Journal of diabetes research IF: 03.400Volume 2025, Issue No.114Pilot Study of Early Adoption of Automated Insulin Delivery in Underresourced Youth资源不足青少年中早期采用自动化胰岛素输送的试点研究DOI: 10.1155/jdr/6886806
Curēus IF: 01.300Volume 17, Issue 10No.115The Effect of Diabetic Neuropathy on Recurrent Laryngeal Nerve Monitoring During Thyroid Surgery糖尿病神经病变对甲状腺手术中喉返神经监测的影响DOI: 10.7759/cureus.94739
Am J Lifestyle Med IF: 01.300Ahead of Print.No.116Sleep Quality in Patients With Type 2 Diabetes Mellitus2型糖尿病患者的睡眠质量DOI: 10.1177/15598276251395665
BMJ open IF: 02.300Volume 15, Issue 11No.117Sociodemographic and clinical factors associated with non-adherence to stroke medication: an analytical, multi-hospital cross-sectional survey in Punjab, Pakistan社会人口学和临床因素与卒中药物非依从性相关：巴基斯坦旁遮普省的一项分析性、多医院横断面调查DOI: 10.1136/bmjopen-2025-105613
BMJ open IF: 02.300Volume 15, Issue 11No.118Role of e-health in addressing sarcopenic obesity: a scoping review protocol电子健康在应对肌少性肥胖中的作用：一项范围综述方案DOI: 10.1136/bmjopen-2025-103773
J Pediatr Endocrinol Metab IF: 01.000Ahead of Print.No.119The differential impact of automated insulin delivery systems on body mass index in children with type 1 diabetes自动胰岛素输送系统对1型糖尿病儿童体重指数的差异化影响DOI: 10.1515/jpem-2025-0442
PloS one IF: 02.600Volume 20, Issue 11No.120Classifying complex multimorbidity using latent class analysis and machine learning to generate insights into clustering of mental and cardiometabolic conditions使用潜在类别分析和机器学习对复杂共病进行分类以揭示心理和心脏代谢疾病的聚类模式DOI: 10.1371/journal.pone.0335676
Dermatology IF: 02.700Ahead of Print.No.121Ethnic Differences in Hidradenitis Suppurativa: Comorbidities, Lesion Distribution, and Disease Severity in a Taiwanese Population化脓性汗腺炎的种族差异：台湾人群中的共病、病变分布和疾病严重程度DOI: 10.1159/000549610
Neuroepidemiology IF: 04.000Ahead of Print.No.122The role of dietary and lifestyle factors in multiple sclerosis risk in a middle eastern country: A case-control study饮食和生活方式因素在中东国家多发性硬化风险中的作用：一项病例对照研究DOI: 10.1159/000549446
Digestive diseases IF: 02.100Ahead of Print.No.123Risk Factors for Rectal Neuroendocrine Tumors: A Population-Based Cohort Study of Sex-Specific Associations直肠神经内分泌肿瘤的风险因素：一项基于人群的队列研究，探讨性别特异性关联DOI: 10.1159/000549579
Eur J Cancer Prev IF: 02.500Ahead of Print.No.124Cancer as a main contributor to multimorbidity in the UK Biobank: analysis of risk factors using conventional statistical modelling and machine learning癌症是英国生物样本库中多重疾病的主要贡献者：使用传统统计建模和机器学习的风险因素分析DOI: 10.1097/CEJ.0000000000000998
Annals of intensive care IF: 05.500Volume 15, Issue 1No.125Physiological comparison of noninvasive ventilation and CPAP on inspiratory efforts after extubation in critically ill patients with morbid obesity: a post-hoc analysis病态肥胖危重患者拔管后无创通气与CPAP对吸气努力的生理比较：一项事后分析DOI: 10.1186/s13613-025-01603-3
Obesity surgery IF: 03.100Ahead of Print.No.126Surgeons' Perspectives on Insurance Coverage for Metabolic and Bariatric Surgery in India: An Obesity and Metabolic Surgery Society of India (OSSI) Survey印度外科医生对代谢与减重手术保险覆盖的视角：印度肥胖与代谢手术学会（OSSI）调查DOI: 10.1007/s11695-025-08324-3
Obesity surgery IF: 03.100Ahead of Print.No.127What Really Matters in Weight Loss after Bariatric Surgery - 10 Years Follow-Up (BARI-10 -POL Study)减重手术后体重减轻的关键因素 - 10年随访（BARI-10 -POL 研究）DOI: 10.1007/s11695-025-08385-4
Obesity surgery IF: 03.100Ahead of Print.No.128Effects of Bariatric Surgery on Sleep Disorder Symptoms and Sleep Quality减重手术对睡眠障碍症状和睡眠质量的影响DOI: 10.1007/s11695-025-08381-8
Eur J Orthop Surg Traumatol IF: 01.500Volume 36, Issue 1No.129Correction: Fixation in total knee arthroplasty: are cemented implants still mandatory in younger and obese patients?更正：全膝关节置换术中的固定：年轻与肥胖患者中骨水泥植入物是否仍属必需DOI: 10.1007/s00590-025-04590-0
Diabetologia IF: 10.200Ahead of Print.No.130Artificial intelligence-driven clinical decision support systems to assist healthcare professionals and people with diabetes in Europe at the point of care: a Delphi-based consensus roadmap人工智能驱动的临床决策支持系统在欧洲护理点协助医疗专业人员和糖尿病患者：基于德尔菲法的共识路线图DOI: 10.1007/s00125-025-06601-5
Surgery today IF: 01.600Ahead of Print.No.131Incidence of incisional hernia following open repair for an abdominal aortic aneurysm in Japanese patients日本患者腹主动脉瘤开放修复术后切口疝发生率DOI: 10.1007/s00595-025-03175-y
Clinical pharmacokinetics IF: 04.000Ahead of Print.No.132Population Pharmacokinetic Modeling of Oxcarbazepine and Its Active Metabolite 10-Monohydroxy Derivative to Inform Dosing in Children with Obesity奥卡西平及其活性代谢物10-单羟基衍生物在肥胖儿童中的群体药代动力学建模以指导剂量DOI: 10.1007/s40262-025-01579-0
Clinical autonomic research IF: 03.400Ahead of Print.No.133Resting-state brain dynamics are associated with body fat percentage and sympathetic outflow in healthy adults静息态脑动力学与健康成年人体脂百分比和交感神经流出的关联DOI: 10.1007/s10286-025-01173-1
Rev Esp Enferm Dig IF: 04.000Ahead of Print.No.134Improvement in perianal pathology and quality of life after bariatric surgery: prospective multicentric study with 12-month follow-up减重手术后肛周病理和生活质量的改善：12个月随访的前瞻性多中心研究DOI: 10.17235/reed.2025.11639/2025
J Occup Environ Med IF: 01.400Ahead of Print.No.135Work Productivity Burden Among Patients with Obstructive Sleep Apnea and Obesity Compared to Controls without Obstructive Sleep Apnea or Obesity阻塞性睡眠呼吸暂停和肥胖患者与无阻塞性睡眠呼吸暂停或肥胖的对照组相比的工作生产力负担DOI: 10.1097/JOM.0000000000003617
J Neuropsychiatry Clin Neurosci IF: 02.900Ahead of Print.No.136Functional Neurological Disorder, Sleep, and Dreaming: A Large Online Questionnaire-Based Study功能性神经障碍、睡眠与梦境：一项大型在线问卷研究DOI: 10.1176/appi.neuropsych.20250092
Dental and Medical Problems IF: 03.900Ahead of Print.No.137Gallstones, obesity, insulin resistance, and obstructive sleep apnea - current knowledge on the topic: A literature review胆结石、肥胖、胰岛素抵抗与阻塞性睡眠呼吸暂停——当前知识综述：文献回顾DOI: 10.17219/dmp/204402
Wound repair and regeneration IF: 03.400Volume 33, Issue 6No.138Combinatorial Efficacy of Apigenin-Resveratrol Collagen Bio-Matrix for Wound Repair and Regeneration in Abnormal Lipid Expansion芹菜素-白藜芦醇胶原生物基质在异常脂质扩张中伤口修复和再生的组合有效性DOI: 10.1111/wrr.70114
Chronobiology international IF: 01.700Ahead of Print.No.139Late-eating adolescents consume more energy, make poorer dietary choices, and are more likely to have excess weight: An analysis of the Brazilian Household Budget Survey (2008-2009)晚食青少年摄入更多能量，饮食选择较差，且更易超重：基于巴西家庭预算调查（2008-2009）的分析DOI: 10.1080/07420528.2025.2584192
Epigenomics IF: 02.600Ahead of Print.No.140Blood and adipose tissue DNA methylation in adults born preterm with a very low birth weight - a sibling comparison study早产且出生体重极低的成人中血液和脂肪组织的DNA甲基化——一项同胞对照研究DOI: 10.1080/17501911.2025.2583893
Curēus IF: 01.300Volume 17, Issue 10No.141Improvement in Nighttime Awakening Symptoms After Bracing, Injections, and Carpal Tunnel Release夜间觉醒症状在支具固定、注射和腕管松解术后的改善DOI: 10.7759/cureus.94643
Curēus IF: 01.300Volume 17, Issue 10No.142Vertical Banded Gastroplasty Revisions: A Single-Center Experience垂直束带胃成形术修订：单中心经验DOI: 10.7759/cureus.94559
Curēus IF: 01.300Volume 17, Issue 10No.143Stillbirth Trends and Determinants: A Six-Year Registry-Based Analysis From Two District Hospitals in the United Kingdom (2019-2024)死产趋势与决定因素：英国两家地区医院基于登记数据的六年分析（2019-2024）DOI: 10.7759/cureus.94706
Curēus IF: 01.300Volume 17, Issue 10No.144Pulmonary Embolism Following Quadriceps Tendon Repair With Tourniquet Use Despite Adequate Thromboprophylaxis: A Case Report尽管有充分的抗凝预防，使用止血带的四头肌腱修复术后发生肺栓塞：一例病例报告DOI: 10.7759/cureus.94718
Curēus IF: 01.300Volume 17, Issue 10No.145Three-Year Outcomes of Type 2 Diabetes Remission Following Sleeve Gastrectomy and Roux-en-Y Gastric Bypass in Patients With BMI ≥35: A Single-Center Cohort StudyBMI≥35患者袖状胃切除术与Roux-en-Y胃旁路术后2型糖尿病缓解的三年结局：一项单中心队列研究DOI: 10.7759/cureus.94578
Curēus IF: 01.300Volume 17, Issue 10No.146Effectiveness of Telehealth and Wearable Device-Based Interventions for Managing Childhood and Adolescent Obesity: A Systematic Review and Meta-Analysis远程医疗和基于可穿戴设备的干预在管理儿童和青少年肥胖中的有效性：系统回顾与荟萃分析DOI: 10.7759/cureus.94551
Video journal of sports medicineVolume 5, Issue 6No.147Medial Meniscal Transplant: Technique Video内侧半月板移植：技术视频DOI: 10.1177/26350254251347662
IJTLD openVolume 2, Issue 11No.148Development and evaluation of the phenotypic 2G test to detect drug-resistant TB表型2G测试的开发和评估用于检测耐药结核病DOI: 10.5588/ijtldopen.25.0326
Open veterinary journal IF: 01.000Volume 15, Issue 10No.149Therapeutic efficacy of liposomal caffeic acid in high-fat diet-induced obesity in rats: Targeting hedgehog signalling pathway, adipokines, and insulin resistance脂质体咖啡酸在高脂饮食诱导的大鼠肥胖中的治疗有效性：靶向刺猬信号通路、脂肪因子和胰岛素抵抗DOI: 10.5455/OVJ.2025.v15.i10.13
J Hand Surg Glob OnlineVolume 8, Issue 1No.150Carpal Tunnel Release: A Four-Specialty Comparison Demonstrating Equal Clinical and Economic Efficacy腕管松解术：四个专业比较显示相等的临床和经济效益有效性DOI: 10.1016/j.jhsg.2025.100863
Journal of transplantation IF: 02.200Volume 2025, Issue No.151Incidence and Risk Factors of Obesity and Overweight in Kidney Transplant Recipients and Their Effect on Graft Outcome肾移植受者肥胖与超重的发病率、风险因素及其对移植结果的影响DOI: 10.1155/joot/4990973
Frontiers in medical technology IF: 03.800Volume 7, Issue No.152Microbiome-based therapeutics for metabolic disorders: harnessing microbial intrusions for treatment基于微生物组的代谢紊乱疗法：利用微生物干预进行治疗DOI: 10.3389/fmedt.2025.1695329
Journal of Orthopaedics IF: 01.500Volume 71, Issue No.153Hypothyroidism increases risk of early medical and late mechanical complications after primary total knee arthroplasty: A propensity-matched cohort study甲状腺功能减退症增加原发性全膝关节置换术后早期医疗和晚期机械并发症的风险：一项倾向匹配队列研究DOI: 10.1016/j.jor.2025.08.058
Journal of Orthopaedics IF: 01.500Volume 71, Issue No.154Developing and validating machine learning models to predict length of hospitalization before obese patients undergo elective arthroplasty开发和验证机器学习模型以预测肥胖患者在择期关节置换术前住院时间长度DOI: 10.1016/j.jor.2025.10.008
Touch reviews in endocrinologyVolume 21, Issue 2No.155Bridging Medical Specialities in the Management of Polycystic Ovary Syndrome: Integrating Lessons from Sodium-glucose Cotransporter-2 Inhibitors into a Holistic Approach连接医学专业在多囊卵巢综合征管理中的桥梁作用：整合钠-葡萄糖协同转运蛋白-2抑制剂的教训，实现整体方法DOI: 10.17925/EE.2025.21.2.1
Touch reviews in endocrinologyVolume 21, Issue 2No.156Metabolic Syndrome in Older Adults: When Function Trumps Numbers老年人代谢综合征：当功能胜过数字DOI: 10.17925/EE.2025.21.2.6
Touch reviews in endocrinologyVolume 21, Issue 2No.157Association Between Anthropometry and Cognitive Impairment in Patients with Type 2 Diabetes: Secondary Analysis from the 'Cognition in Diabetes' Study2型糖尿病患者人体测量学与认知障碍之间的关联：来自“糖尿病认知”研究的二次分析DOI: 10.17925/EE.2025.21.2.7
Frontiers in public health IF: 03.400Volume 13, Issue No.158Association of the healthy eating index with overweight and obesity among children aged 4 to 9 years in the United Arab Emirates: a cross-sectional study阿联酋4-9岁儿童健康饮食指数与超重和肥胖的关联：一项横断面研究DOI: 10.3389/fpubh.2025.1644113
Frontiers in public health IF: 03.400Volume 13, Issue No.159Obesity, daily life restrictions, and health behaviors during the COVID-19 pandemic in Korea韩国COVID-19大流行期间的肥胖、日常生活限制和健康行为DOI: 10.3389/fpubh.2025.1653576
Curēus IF: 01.300Volume 17, Issue 11No.160Quality of Life Outcomes After Fundoplication-Augmented One-Anastomosis Gastric Bypass: A Randomized Comparative Study胃底折叠术增强的单吻合口胃旁路术后生活质量结局：一项随机比较研究DOI: 10.7759/cureus.96802
Metabolism open IF: 02.700Volume 28, Issue No.161Liver transplantation in the era of obesity: A metabolic public health crisis meets a surgical frontier肥胖时代的肝移植：代谢公共卫生危机与外科前沿的碰撞DOI: 10.1016/j.metop.2025.100410
Frontiers in neurology IF: 02.800Volume 16, Issue No.162Elemental imbalance and oxidative biomarker shifts in lumbar disc degeneration腰椎间盘退变中的元素不平衡与氧化生物标志物变化DOI: 10.3389/fneur.2025.1662845
SSM, population health IF: 03.100Volume 32, Issue No.163Examining the reversal hypothesis on socioeconomic status and noncommunicable diseases, and gender disparities in China: a nationwide longitudinal analysis between 1991 and 2020检验社会经济地位与非传染性疾病的反转假说及中国的性别差异：1991年至2020年全国性纵向分析DOI: 10.1016/j.ssmph.2025.101867
Obesity science & practice IF: 01.900Volume 11, Issue 6No.164Impact of an MRI Body Fat Imaging Report on Obesity-Related Cardiometabolic Risk: Findings From the BODY-REAL Study, A Randomized TrialMRI体脂成像报告对肥胖相关心血管代谢风险的影响：来自BODY-REAL研究（一项随机试验）的发现DOI: 10.1002/osp4.70099
Health affairs scholarVolume 3, Issue 11No.165The unintended health effects of US COVID-19 lockdowns: a systematic review美国COVID-19封锁的非预期健康影响：一项系统综述DOI: 10.1093/haschl/qxaf208
Frontiers in nutrition IF: 05.100Volume 12, Issue No.166Opposing effects of sugar-free claims on perceived healthiness and sweetness reduce consumers' willingness to pay for sugar-free products无糖声称对感知健康度和甜度的相反影响降低消费者对无糖产品的支付意愿DOI: 10.3389/fnut.2025.1644753
Frontiers in psychology IF: 02.900Volume 16, Issue No.167The relationship between religious coping with body image concern among patients on hemodialysis: the mediating role of self-care血液透析患者宗教应对与身体意象关注的关系：自我护理的中介作用DOI: 10.3389/fpsyg.2025.1498416
Indian journal of orthopaedics IF: 01.100Volume 59, Issue 11No.168Prevalence of Flat Foot in South Indian School Going Children and Concordance between Stahelis Plantar Arch Index, Chippaux Smirak Index and Denis Foot Print Grade in Diagnosing Flat Foot南印度学龄儿童扁平足患病率及Staheli足弓指数、Chippaux-Smirak指数与Denis足印分级在诊断扁平足中的一致性DOI: 10.1007/s43465-025-01486-3
Indian journal of orthopaedics IF: 01.100Volume 59, Issue 11No.169Prevalence of Knee Osteoarthritis in India: A Systematic Review and Meta-Analysis of Population-Based Studies印度膝关节骨关节炎患病率：基于人群研究的系统回顾与荟萃分析DOI: 10.1007/s43465-025-01520-4
Public health in practice IF: 01.900Volume 10, Issue No.170Obesity effects on the health-related quality of life in Japan: Implications from a cross-sectional study肥胖对日本健康相关生活质量的影响：基于横断面研究的启示DOI: 10.1016/j.puhip.2025.100674
JPGN reportsVolume 6, Issue 4No.171Correction to "627/72. Diagnostic indicators of malnutrition in children with obesity"更正“627/72. 儿童肥胖中营养不良诊断指标”DOI: 10.1002/jpr3.70071
JPGN reportsVolume 6, Issue 4No.172The 10-year status of pediatric gastroenterologists' perception of their roles in the management of childhood obesity儿科胃肠病学家对儿童肥胖管理中自身角色认知的10年状况DOI: 10.1002/jpr3.70075
JPRAS open IF: 01.800Volume 46, Issue No.173A scoping review of the Goldilocks mastectomyGoldilocks乳房切除术的范围综述DOI: 10.1016/j.jpra.2025.09.031
PeerJ IF: 02.400Volume 13, Issue No.174Modified STOP-Bang questionnaire for detecting obstructive sleep apnea in individuals with a body mass index below 35 kg/m(2)修改版STOP-Bang问卷用于检测体重指数低于35 kg/m²个体的阻塞性睡眠呼吸暂停DOI: 10.7717/peerj.20310
Royal Society open science IF: 02.900Volume 12, Issue 11No.175The long-term impact of obesity in pregnancy on offspring hypothalamic feeding pathways孕期肥胖对后代下丘脑喂养途径的长期影响DOI: 10.1098/rsos.250681
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.176From awareness to action: evolving endocrinologist practices in obesity treatment in Italy从认识到行动：意大利内分泌学家在肥胖治疗中的实践演变DOI: 10.3389/fendo.2025.1705670
J Clin Invest IF: 13.600Volume 135, Issue 22No.177Estrogen and obesity synergistically suppress protein S via HIF1α, enhancing thrombosis potential雌激素和肥胖通过HIF1α协同抑制蛋白S，增强血栓形成潜力DOI: 10.1172/JCI193976
Headache IF: 04.000Ahead of Print.No.178Effect of GLP-1 receptor agonists on idiopathic intracranial hypertension: A systematic reviewGLP-1受体激动剂对特发性颅内高压的影响：一项系统综述DOI: 10.1111/head.70005
Touch reviews in endocrinologyVolume 21, Issue 2No.179Dual GIP/GLP1-RA, GCGR/GLP-1 RA and GLP1-RA for the Treatment of Metabolic Dysfunction-associated Steatotic Liver Disease with Type 2 Diabetes: A Systematic Review and Meta-analysis双GIP/GLP-1受体激动剂、GCGR/GLP-1受体激动剂和GLP-1受体激动剂治疗2型糖尿病合并代谢功能障碍相关脂肪性肝病的系统回顾和荟萃分析DOI: 10.17925/EE.2025.21.2.5
JoVE IF: 01.000Volume 2025, Issue 224No.180An Obstructive Chronic Pancreatitis Model Established Through Electrocoagulation通过电凝术建立的阻塞性慢性胰腺炎模型DOI: 10.3791/67061
Global Heart IF: 03.100Volume 20, Issue 1, Page 1-1No.181The European Program for Prevention (EPP) - Implementing Proven Preventing Measures Now!欧洲预防计划（EPP）——立即实施已验证的预防措施DOI: 10.5334/gh.1491
Curēus IF: 01.300Volume 17, Issue 10No.182A Triple Threat: Immune Checkpoint Inhibitor-Induced Diabetic Ketoacidosis, Myocarditis, and Adrenal Insufficiency in a Patient With Metastatic Melanoma三重威胁：免疫检查点抑制剂诱导的糖尿病酮症酸中毒、心肌炎和肾上腺功能不全在一例转移性黑色素瘤患者中DOI: 10.7759/cureus.94583
JPRAS open IF: 01.800Volume 46, Issue No.183Comparison of the effect of preemptive pregabalin versus pethidine on postoperative pain after septorhinoplasty比较术前普瑞巴林与术后哌替啶对鼻中隔成形术后疼痛的影响DOI: 10.1016/j.jpra.2025.09.025
Thyroid IF: 06.700Volume 35, Issue 11No.184Scholarly Dialogue on Risk to the Recurrent Laryngeal Nerve with Thermal Ablation Procedures: A Reflection on Empirical Practices热消融手术中喉返神经风险的学术对话：对经验性实践的反思DOI: 10.1177/10507256251390376
Rev Esp Enferm Dig IF: 04.000Ahead of Print.No.185Plasma protein glycosylation: a biomarker for predicting metabolic dysfunction-associated steatotic liver disease in inflammatory bowel disease血浆蛋白糖基化：预测炎症性肠病中代谢功能障碍相关脂肪性肝病的生物标志物DOI: 10.17235/reed.2025.11575/2025
Korean J Community NutrVolume 30, Issue 5No.186Self-reported weight change and diet quality in relation to metabolic syndrome among Korean cancer survivors: a cross-sectional study using the Korea National Health and Nutrition Examination Survey 2019-2021自报体重变化和饮食质量与韩国癌症幸存者代谢综合征的关系：一项使用2019-2021年韩国国民健康与营养调查的横断面研究DOI: 10.5720/kjcn.2025.00241
Ther Innov Regul Sci IF: 01.900Ahead of Print.No.187Nitrosamine Contamination in Pharmaceuticals: A Retrospective Regulatory Analysis of USFDA Recalls and Risk Mitigation Strategies (2018-2025)药品中亚硝胺污染：美国FDA召回和风险缓解策略的回顾性监管分析（2018-2025）DOI: 10.1007/s43441-025-00891-y
World J Emerg Med IF: 03.200Volume 16, Issue 6No.188The protective role of metformin against severe dengue disease in patients with type 2 diabetes mellitus: a preliminary report in Mexico二甲双胍对2型糖尿病患者严重登革热疾病的保护作用：墨西哥的初步报告DOI: 10.5847/wjem.j.1920-8642.2025.105
Touch reviews in endocrinologyVolume 21, Issue 2No.189Foetal Metformin Exposure, Childhood Adiposity and Future Cardiovascular Risk: Can We Connect the Dots?胎儿二甲双胍暴露、儿童期肥胖与未来心血管风险：我们能连接这些点吗？DOI: 10.17925/EE.2025.21.2.4
BMJ open IF: 02.300Volume 15, Issue 11No.190Heart failure in Southern Sweden (HISS): a cross-sectional analysis of primary care patients' characteristics and physicians' adherence to guideline-directed medical therapy瑞典南部心力衰竭（HISS）：初级护理患者特征及医生对指南导向药物治疗依从性的横断面分析DOI: 10.1136/bmjopen-2025-101178
Neurol Neuroimmunol Neuroinflamm IF: 07.500Volume 13, Issue 1No.191Distinct Epitopes Are Associated With Clinical Phenotypes in Autoimmune Nodopathies With Anti-Contactin1 Autoantibodies不同表位与伴有抗Contactin1自身抗体的自身免疫性结节病临床表型相关DOI: 10.1212/NXI.0000000000200507
Am J Physiol Cell Physiol IF: 04.700Ahead of Print.No.192Emerging Roles of Astrocytes in Autonomic Control of Blood Pressure and Hypertension星形胶质细胞在自主控制血压和高血压中的新兴作用DOI: 10.1152/ajpcell.00587.2025
JAMA Pediatrics IF: 18.000Ahead of Print.No.193Once-Weekly Navepegritide in Children With Achondroplasia: The APPROACH Randomized Clinical Trial每周一次Navepegritide在软骨发育不全儿童中的应用：APPROACH随机临床试验DOI: 10.1001/jamapediatrics.2025.4771
JAMA IF: 55.000Ahead of Print.No.194Peripheral Neuropathy: A Review周围神经病变：综述DOI: 10.1001/jama.2025.19400
Diabetes IF: 07.500Ahead of Print.No.195Cerebrospinal Fluid Fatty Acids, Hypothalamic Inflammation, and Weight Loss in Human Obesity: A Longitudinal Study脑脊液脂肪酸、下丘脑炎症与人类肥胖中的体重减轻：一项纵向研究DOI: 10.2337/db25-0595
JAMA Network Open IF: 09.700Volume 8, Issue 11No.196Racial and Ethnic Disparities in Cesarean Birth Trends in the United States美国剖宫产趋势中的种族与民族差异DOI: 10.1001/jamanetworkopen.2025.44078
JAMA Internal Medicine IF: 23.300Ahead of Print.No.197Sex Differences in Mortality and Receipt of Kidney Replacement Therapy Among Adults With Stage 5 Chronic Kidney Disease成人5期慢性肾脏病患者死亡率和肾脏替代治疗接受率的性别差异DOI: 10.1001/jamainternmed.2025.5979
Cell Mol Neurobiol IF: 04.800Volume 45, Issue 1No.198Comprehensive Molecular Evaluation of Transcription Factor 7-like 2, Long Noncoding RNA (ANRIL), and CYP2C19*17 Gene Variants and Their Association with Predisposition and Progression in Stroke Patients全面分子评估转录因子7样2、长链非编码RNA（ANRIL）和CYP2C19*17基因变异及其与卒中患者易感性和进展的关联DOI: 10.1007/s10571-025-01625-2
J Plast Surg Hand Surg IF: 00.900Volume 60, Issue No.199Risk factors for free flap failure in the reconstruction of diabetic foot ulcers糖尿病足溃疡重建中游离皮瓣失败的风险因素DOI: 10.2340/jphs.v60.44803
JAHA IF: 05.300Ahead of Print.No.200Circulating Markers of Inflammation and Endothelial Dysfunction Associated With Increased Progression of Internal Carotid Intima-Media Thickness in the Population-Based Framingham Heart Study在基于人群的Framingham心脏研究中，循环炎症和内皮功能障碍标志物与颈内动脉内膜中层厚度进展增加相关DOI: 10.1161/JAHA.124.040460
Drug Deliv Transl Res IF: 05.500Ahead of Print.No.201Dual drug co-encapsulation into liposomes and liposome-derived nanosystems for improved synergistic treatment of skin diseases双药物共封装于脂质体及其衍生纳米系统以改善皮肤疾病的协同治疗DOI: 10.1007/s13346-025-02016-2
Frontiers in pharmacology IF: 04.800Volume 16, Issue No.202Bangpungtongsung-san alleviates depressive-like behavior and metabolic disturbances in high-fat diet-induced obesity: mechanisms involving inflammation, CREB/BDNF signaling, and NMDA receptor modulationBangpungtongsung-san 缓解高脂饮食诱导肥胖中的抑郁样行为与代谢紊乱：机制涉及炎症、CREB/BDNF信号通路及NMDA受体调节DOI: 10.3389/fphar.2025.1565592
Indian J Dent ResAhead of Print.No.203Association of Periodontitis with Cardiometabolic Risk Factors in Post-menopausal Women with Type 2 Diabetes Mellitus - A Comparative Study牙周炎与2型糖尿病绝经后女性心脏代谢风险因素的关联 - 一项比较研究DOI: 10.4103/ijdr.ijdr_756_23
Journal of diabetes research IF: 03.400Volume 2025, Issue No.204Effect of Glucagon-Like Peptide-1 Receptor Agonists on Renal and Cardiovascular Risk Factors in Patients With Type 2 Diabetes Mellitus: A Retrospective Study胰高血糖素样肽-1受体激动剂对2型糖尿病患者肾及心血管风险因素的影响：一项回顾性研究DOI: 10.1155/jdr/2663671
Health science reports IF: 02.100Volume 8, Issue 11No.205Effects of Propolis Supplementation on Metabolic Syndrome Indices, Isfahan, Iran, 2023: A Randomized Controlled Clinical Trial蜂胶补充对代谢综合征指标的影响：伊朗伊斯法罕2023年随机对照临床试验DOI: 10.1002/hsr2.71499
Am J Cardiovasc Drugs IF: 03.000Ahead of Print.No.206Cardiovascular Pharmacotherapy and Glucose Metabolism: The Good, the Bad and the Unsightly心血管药物治疗与葡萄糖代谢：益处、风险与隐忧DOI: 10.1007/s40256-025-00777-2
RSC medicinal chemistry IF: 03.600Ahead of Print.No.2072-Oxoindolin-thiazoline hybrids as scaffold-based therapeutics for T2DM-associated cognitive impairment: design, synthesis, in vitro and in silico studies2-氧代吲哚啉-噻唑啉杂合物作为基于支架的疗法用于T2DM相关认知障碍：设计、合成、体外和计算机研究DOI: 10.1039/d5md00628g
ACS omega IF: 04.300Volume 10, Issue 44No.208Experimental and Computational Insights of a Benzytrietylammonium [CoBr(4)] Salt: A Potential Photocatalyst and Inflammation-Related Enzyme InhibitorBenzytrietylammonium [CoBr(4)]盐的实验与计算见解：一种潜在的光催化剂和炎症相关酶抑制剂DOI: 10.1021/acsomega.5c01220
Curēus IF: 01.300Volume 17, Issue 10No.209Cardiovascular Sequel in Type-2 Diabetes Mellitus Patients on Various Dipeptidyl Peptidase-4 (DPP-4) Inhibitors: A Systemic Review and Meta-Analysis2型糖尿病患者使用不同二肽基肽酶-4抑制剂的心血管后遗症：系统回顾与荟萃分析DOI: 10.7759/cureus.94567
Cerebral cortex IF: 02.900Volume 35, Issue 11No.210Functional topography of glutamatergic and GABAergic neurotransmissions along the rostrocaudal axis of the posterior insular cortex regulating cardiovascular/autonomic responses to stress in rats谷氨酸能和GABA能神经传递沿后岛叶皮层吻尾轴的功能拓扑调节大鼠应激心血管/自主神经反应DOI: 10.1093/cercor/bhaf304
The journal of physiology IF: 04.400Ahead of Print.No.211Isolating the effects of carbohydrate and lipid availability on exercise-induced skeletal muscle signalling in males分离碳水化合物和脂质可用性对运动诱导骨骼肌信号传导的影响（男性）DOI: 10.1113/JP289864
The journal of physiology IF: 04.400Ahead of Print.No.212Histamine mediates food intake, but not muscle adaptations, following 10 weeks of resistance training in humans组胺介导食物摄入，但不介导肌肉适应，在人类10周阻力训练后DOI: 10.1113/JP289240
Diabetes & metabolism journal IF: 08.500Volume 49, Issue 6No.213Effects of CXCR1/2 Blockade with Ladarixin on Streptozotocin-Induced Type 1 Diabetes Mellitus and Peripheral Neuropathy and Retinopathy in Rat (Diabetes Metab J 2025;49:990-1005)Ladarixin阻断CXCR1/2对链脲佐菌素诱导的1型糖尿病及周围神经病变和视网膜病变在大鼠中的影响DOI: 10.4093/dmj.2025.0927
Diabetes & metabolism journal IF: 08.500Volume 49, Issue 6No.214Effects of CXCR1/2 Blockade with Ladarixin on Streptozotocin-Induced Type 1 Diabetes Mellitus and Peripheral Neuropathy and Retinopathy in Rat (Diabetes Metab J 2025;49:990-1005)Ladarixin 阻断 CXCR1/2 对 Streptozotocin 诱导的大鼠 Type 1 Diabetes Mellitus 及其 Peripheral Neuropathy 和 Retinopathy 的影响DOI: 10.4093/dmj.2025.0801
J Pak Med Assoc IF: 00.800Volume 75, Issue 10No.215Association of maternal obesity and gestational weight gain with adverse maternal and perinatal outcomes母体肥胖与妊娠期体重增加与不良母婴结局的关联DOI: 10.47391/JPMA.20564
J Pak Med Assoc IF: 00.800Volume 75, Issue 10No.216Frequency of diastasis rectus abdominis and its association with obesity in post menopausal women: a cross-sectional study绝经后女性腹直肌分离发生率及其与肥胖的关联：一项横断面研究DOI: 10.47391/JPMA.21989
Am J Hum Biol IF: 01.700Volume 37, Issue 11No.217Physical, Psychological, and Behavioral Symptoms of Premenstrual Syndrome in Relation to Body Size and Shape经前综合征的身体、心理和行为症状与身体大小和形状的关系DOI: 10.1002/ajhb.70169
Community Dent Oral Epidemiol IF: 02.100Ahead of Print.No.218Patterns and Predictors of Toothbrushing Frequency in Irish Adolescents: The Role of Autism and Intellectual Disability爱尔兰青少年刷牙频率的模式与预测因素：自闭症和智力残疾的作用DOI: 10.1111/cdoe.70038
Gut microbes IF: 11.000Volume 17, Issue 1No.2192'-Fucosyllactose supplementation results in a transient improvement in gut microbial resilience after vancomycin use in adults with overweight or obesity: a randomized, double-blind, placebo-controlled intervention2'-Fucosyllactose 补充在使用万古霉素后导致超重或肥胖成人肠道微生物韧性短暂改善：一项随机、双盲、安慰剂对照干预研究DOI: 10.1080/19490976.2025.2580693
Obesity IF: 04.700Ahead of Print.No.220Association Between Wake-Time Movement Behaviors and Weight Loss Maintenance清醒时间运动行为与减重维持的关联DOI: 10.1002/oby.70082
Health education & behavior IF: 02.100Ahead of Print.No.221Untangling the Relationship Between Income Inequality and Poly-Substance Use Among Adolescents in Canada理清加拿大青少年中收入不平等与多物质使用之间的关系DOI: 10.1177/10901981251389952
Diabetes & metabolism journal IF: 08.500Volume 49, Issue 6No.222A Snapshot of Cardiometabolic Health in Young Adults without Obesity Reveals High Rates of Dysglycemia非肥胖年轻成人心血管代谢健康现状调查揭示高比例血糖异常DOI: 10.4093/dmj.2025.0649
Diabetes & metabolism journal IF: 08.500Volume 49, Issue 6No.223Bridging Efficacy and Adherence in Glucagon-Like Peptide-1 Receptor Agonist Therapy: The Emerging Role of Oral Agents弥合GLP-1受体激动剂治疗中的有效性与依从性：口服药物的新兴作用DOI: 10.4093/dmj.2025.0666
Journal of forensic sciences IF: 01.800Ahead of Print.No.224Elevated beta-hydroxybutyrate within a pediatric population and its associated pathology: A retrospective case series儿科人群中升高的β-羟基丁酸及其相关病理学：一项回顾性病例系列研究DOI: 10.1111/1556-4029.70227
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.225Comment on "Indirect comparative efficacy and safety of tirzepatide 10 and 15 mg versus semaglutide 2.4 mg for the management of obesity and overweight in patients with type 2 diabetes"替尔泊肽10和15毫克与司美格鲁肽2.4毫克在2型糖尿病患者肥胖和超重管理中的间接比较有效性和安全性DOI: 10.1111/dom.70294
Diabetes & metabolism journal IF: 08.500Volume 49, Issue 6No.226Bridging Evidence and Practice: A Consensus Statement from the Korean Diabetes Association on Diabetes Screening, Pharmacological Treatment and Severe Diabetes连接证据与实践：韩国糖尿病协会关于糖尿病筛查、药物治疗和严重糖尿病的共识声明DOI: 10.4093/dmj.2025.0978
Echocardiography IF: 01.400Volume 42, Issue 11No.227Cardiac Structure and Function Among Patients With Heart Failure With Reduced Ejection Fraction and Kidney Disease射血分数降低的心力衰竭和肾脏疾病患者的心脏结构与功能DOI: 10.1111/echo.70341
J Pak Med Assoc IF: 00.800Volume 75, Issue 10No.228Masked malnutrition隐匿性营养不良DOI: 10.47391/JPMA.25-78
J Pak Med Assoc IF: 00.800Volume 75, Issue 10No.229The obestrung personality: A clinical confounder of obesity肥胖紧张人格：肥胖的一个临床混杂因素DOI: 10.47391/JPMA.25-77
J Pak Med Assoc IF: 00.800Volume 75, Issue 10No.230Medical termination of unplanned pregnancies in women with diabetes糖尿病女性非计划妊娠的医疗终止DOI: 10.47391/JPMA.25-76
Medical journal of Australia IF: 08.500Ahead of Print.No.231Rethinking diabetes care for Indigenous Australians: the need for Indigenous-codesigned and led diabetes models of care重新思考澳大利亚原住民糖尿病护理：需要原住民共同设计与领导的糖尿病护理模式DOI: 10.5694/mja2.70108
Diabetic medicine IF: 03.400Ahead of Print.No.232Reply to Manne-Goehler et al. regarding 'Marked improvement in HbA1c following introduction of biosimilar insulin to treatment regimen of children and youth with type 1 diabetes in Mali: A randomised controlled trial'对Manne-Goehler等人关于“在马里1型糖尿病儿童和青少年治疗方案中引入生物类似胰岛素后HbA1c显著改善：一项随机对照试验”的回复DOI: 10.1111/dme.70159
Pain practice IF: 02.700Volume 26, Issue 1No.233Commentary on "Efficacy and Safety of Once-Daily Prolonged-Release Pregabalin for the Treatment of Patients With Diabetic Peripheral Neuropathy: A Randomized, Double-Blind, Active, and Placebo-Controlled Trial"每天一次缓释普瑞巴林治疗糖尿病周围神经病变患者的有效性和安全性：一项随机、双盲、活性药物和安慰剂对照试验DOI: 10.1111/papr.70105
J Hum Nutr Diet IF: 02.500Volume 38, Issue 6No.234Validity of Weighed and Digital Photography Diet Estimation Study in a Childcare Setting在托儿所环境中称重与数字摄影饮食估计研究的有效性DOI: 10.1111/jhn.70160
Glob Health Action IF: 02.600Volume 18, Issue 1No.235Underlying conditions associated with adverse COVID-19 treatment outcomes in selected Kenyan hospitals, October 2020 to December 2021在选定的肯尼亚医院中基础疾病与不良COVID-19治疗结局的关联（2020年10月至2021年12月）DOI: 10.1080/16549716.2025.2572010
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.236Recommendations for real-world evidence of efficacy and safety of GLP-1 agonists in Prader-Willi syndrome: Report of a workshop held by the Foundation for Prader-Willi Research and International Prader Willi Syndrome Organisation关于GLP-1 agonists在Prader-Willi syndrome中有效性和安全性的真实世界证据建议：由Foundation for Prader-Willi Research和International Prader Willi Syndrome Organisation举办的研讨会报告DOI: 10.1111/dom.70282
J Clin Endocrinol Metab IF: 05.100Ahead of Print.No.237Brown Adipose Tissue and Metabolic Markers Differ Between Greenlanders and Danes with Cold-Activation冷激活下格陵兰人与丹麦人的棕色脂肪组织及代谢标记物差异DOI: 10.1210/clinem/dgaf615
Diabetes & metabolism journal IF: 08.500Volume 49, Issue 6No.238Clinical Phenotypes of Diabetic Peripheral Neuropathy: Implications for Phenotypic-Based Therapeutics Strategies (Diabetes Metab J 2025;49:542-64)糖尿病周围神经病变的临床表型：对基于表型的治疗策略的启示DOI: 10.4093/dmj.2025.0759
Diabetes & metabolism journal IF: 08.500Volume 49, Issue 6No.239On a Phenotypic Approach to Diabetic Peripheral Neuropathy (Diabetes Metab J 2025;49:542-64)糖尿病周围神经病变的表型方法 (Diabetes Metab J 2025;49:542-64)DOI: 10.4093/dmj.2025.0611
Diabetes & metabolism journal IF: 08.500Volume 49, Issue 6No.240Association between Fatty Liver Index and Incident Diabetes according to Alcohol Consumption Status in Young Adults脂肪肝指数与新发糖尿病在年轻成人中的关联：基于饮酒状态DOI: 10.4093/dmj.2025.0992
Diabetes & metabolism journal IF: 08.500Volume 49, Issue 6No.241Anthropometric Changes and Risk of Visual Impairment in Patients with Newly Diagnosed Type 2 Diabetes Mellitus新诊断2型糖尿病患者人体测量学变化与视力障碍风险DOI: 10.4093/dmj.2025.0779
Diabetes & metabolism journal IF: 08.500Volume 49, Issue 6No.242A New Era in Islet Transplantation: Stem Cell-Derived and Gene-Edited Islet Therapies胰岛移植的新时代：干细胞来源与基因编辑的胰岛疗法DOI: 10.4093/dmj.2025.0999
Diabetes & metabolism journal IF: 08.500Volume 49, Issue 6No.243Preventing End-Stage Kidney Disease in Older Adults with Type 2 Diabetes Mellitus: Optimal Blood Pressure Targets预防2型糖尿病老年患者终末期肾病：最佳血压目标DOI: 10.4093/dmj.2025.1017
Diabetes & metabolism journal IF: 08.500Volume 49, Issue 6No.244Optimizing Physical Activity Strategies for Older Adults with Diabetes优化老年糖尿病患者体力活动策略DOI: 10.4093/dmj.2025.0967
Journal of Alzheimer's disease IF: 03.100Ahead of Print.No.245A multi-modal medical management and lifestyle intervention increase cerebral blood flow and lowers diabetic risk in persons with early Alzheimer's disease: Mid-trial results from the PREVENTION trial多模式医疗管理与生活方式干预增加脑血流量并降低早期阿尔茨海默病患者的糖尿病风险：PREVENTION试验中期结果DOI: 10.1177/13872877251388933
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198
Diabetes Mellitus(DM)
糖尿病
131
Obesity
肥胖症
67
Insulin
胰岛素
45
Type 2 diabetes mellitus(T2DM)
2型糖尿病
17
Metabolic Syndrome
代谢综合征
13
Diabetic Kidney Disease(DKD)
糖尿病肾脏病
11
Hypoglycemic Agents
降糖药
10
Glucagon-Like Peptide-1 Receptor Agonists(GLP-1RA)
胰高血糖素样肽-1受体激动剂
10
Diabetic Retinopathy
糖尿病视网膜病
8
Diabetic acidosis
糖尿病性酸中毒
8
Metformin
二甲双胍
7
Semaglutide
司美格鲁肽
6
Gestational Diabetes Mellitus(GDM)
妊娠糖尿病
6
Type 1 diabetes mellitus(T1DM)
1型糖尿病
5
Diabetic Neuropathies
糖尿病性神经病变
4
Tirzepatide
替尔泊肽
3
Liraglutide
利拉鲁肽
3
Diabetic Foot
糖尿病足
3
Pregabalin
普瑞巴林
2
Diabetes Complications
糖尿病并发症
2
Dipeptidyl-Peptidase IV Inhibitors(DPP-4i)
二肽基肽酶-4抑制剂
2
Sitagliptin
西他列汀
1
Saxagliptin
沙格列汀
1
Linagliptin
利格列汀
1
Alogliptin
阿格列汀
1
Exenatide
艾塞那肽
1
Gastrointestinal lipase inhibitor
胃肠道脂肪酶抑制剂
1
Orlistat
奥利司他
1
Sodium-Glucose Transporter 2 Inhibitors(SGLT-2i)
钠-葡萄糖协同转运蛋白2抑制剂
1
Dapagliflozin
达格列净
1
Empagliflozin
恩格列净
1
Painful Diabetic Peripheral Neuropathy(PDPN)
痛性糖尿病周围神经病变
1
gamma-Aminobutyric Acid(GABA)
γ-氨基丁酸
1
Gabapentin
加巴喷丁
1
Diabetic Angiopathies
糖尿病血管病变
编辑：韩玉莲
审校：韩玉莲
临床结果
2025-11-14
叶国强 鄢毅 张达颖△
（南昌大学第一附属医院疼痛科，南昌 330000）
摘要：带状疱疹相关性疼痛是临床上最常见的神经病理性疼痛之一，此类疼痛往往严重影响人们的日常生活。目前关于该病的现有研究报道主要集中在其发病机制及治疗手段，但由于机制交叉复杂，对于不同病程中其优先治疗方案国内外尚无充足的证据链，尤其是后遗痛阶段，治疗效果往往达不到预期。因此，未来我们应重点关注针对于机制的药物研发以及并发症的防治。本文将基于国内外现有文献对该病的机制与治疗方法进行总结更新，以期为临床治疗提供新思路。
带状疱疹 (herpes zoster, HZ) 是一种潜伏于人体内的水痘-带状疱疹病毒 (varicella-zoster virus, VZV)再激活而引起的感染性皮肤病，其临床特点为水疱性皮疹和受累皮肤的神经病理性疼痛。带状疱疹在几周后消失，但神经损伤引起的带状疱疹相关性疼痛 (zoster-associated pain, ZAP) 可在受影响的区域持续数月甚至更长时间，严重影响病人的生活质量及参与日常生活活动的能力。ZAP 是指疱疹病人在出疹前、出疹期间或皮损愈合后出现的神经痛，包括急性带状疱疹神经痛及带状疱疹后神经痛 (postherpetic neuralgia, PHN)。在国内，急性带状疱疹神经痛是指疱疹发病后1个月以内的疼痛，PHN 指皮损愈合后持续 1 个月及以上的疼痛，可常年不愈，是一种难治性慢性疼痛综合征。欧美等发达地区由于疫苗使用更为先进，ZAP 的发生相对少于国内，因早期药物控制佳，病人不易疼痛慢性化，且基于国外对于慢性疼痛的时间界定，故将 PHN 定义为 HZ 皮损愈合后持续 3 个月及以上的疼痛。PHN 病人往往因疼痛伴随影响情绪、睡眠等，长期治疗对心理及经济方面的影响不容忽视。现有的治疗策略旨在减轻 HZ 急性期疼痛并预防或延缓疼痛慢性化。国外学者致力于带状疱疹疫苗的研发，对于 ZAP 的治疗大多在药物方面达成共识，而介入治疗方面研究报道相对较少；国内虽然已提出较多关于该病的药物及介入等治疗手段，但由于不同疾病阶段的 ZAP 发病机制存在交叉较为复杂，导致其对同种治疗方法存在较大的疗效差异，不同治疗措施所适用的时期也不尽相同，目前尚未形成统一标准，通过联合治疗可能会提供更好地效果，因此需要为病人选择个性化的治疗方案。本文将重点对 ZAP 的治疗相关最新研究证据及进展进行综述，以期为 ZAP 的临床治疗提供新思路。
一、流行病学
ZAP 在全球范围内均有发生，Zhang 等报告ZAP 在中国的发病率约为 4.28‰，Kawai 等研究发现 ZAP 在北美及欧洲地区的发病率同亚太地区相似，据统计在 3‰ ～5‰之间，而在拉丁美洲及非洲关于此方面的研究报道较少。ZAP 在≥ 60 岁的老年群体中更容易发生，在≥ 70 岁时其发病率达到峰值。此外女性相对于男性更易发生 PHN。Kwan 等研究发现 HZ 在系统性红斑狼疮病人中普遍流行，可能与糖皮质激素的使用有关。McKay等研究表明，造血细胞移植、癌症、艾滋病和实体器官移植等此类免疫功能低下群体的成年病人，ZAP 发病率明显高于正常成年人。总的来说，高龄女性和免疫低下病人是 ZAP 的高危群体。
二、发病机制
ZAP 的发生机制目前尚不完全明确，可能与脊髓及脊髓以上痛觉相关神经元的兴奋性异常升高和突触传递增强（中枢敏化）或伤害性感受神经元对传入信号的敏感性增加（外周敏化）相关。Li 等研究证实，VZV 通过上调背根神经节和脊髓背角中T 型钙离子通道 α1H 亚基上 Cav3.2 基因的表达来参与 ZAP 的维持。然而，不同病程中可能存在不同机制主导或多种机制并存的现象，急性期疼痛属于伤害感受性疼痛，部分伴有神经病理性疼痛，非急性期疼痛则属于典型的神经病理性疼痛，这也对疼痛表现和治疗决策形成一定影响。
三、临床表现
1. 分期
急性与亚急性期疼痛：发疹前常有乏力、低热、食欲不振等全身症状，皮损出现前（前驱痛）、皮损期和皮损出现后疼痛，常表现为烧灼样、针刺样、电击样痛或钝痛，可伴皮肤感觉过敏或瘙痒。
PHN：受累部位通常大于皮损区域，可表现为：①烧灼样或针刺样痛，常持续发作；②电击样痛、撕裂样痛、放射样痛或跳痛，间断性发作；③痛觉过敏或痛觉超敏；④皮肤感觉过敏和感觉异常。
2. 皮损特点
典型皮损表现为沿皮节单侧分布的成簇性水疱伴疼痛，常见于单侧胸背部或头面部，其中肋间神经占 50%、颈枕神经、三叉神经（主要是眼支）、腰丛各占 10%～20%，骶尾神经占 2%～8%，其他部位 < 1%。
3. 特殊临床类型
（1）眼带状疱疹 (herpes zoster ophthalmicus, HZO)：HZO 为 VZV 累及三叉神经眼支引起，其特征是前额、眼部、鼻腔上部或鼻梁部疱疹区疼痛及水泡或丘疹簇，50%～85% 的 HZO 病例出现结膜炎、葡萄膜炎、巩膜外层炎、角膜炎或视网膜炎等眼部不适，甚至还可出现视神经炎、视神经肿胀、视神经水肿、动眼神经麻痹等，罕见的并发症有脑炎、脑血管炎。有研究证实 HZO 发生 PHN 的概率远高于其他部位，且其发病率在 50 岁以上人群显著增加。HZO 是眼科急症，如不早期干预，不仅增加 PHN发生风险，严重者还会造成视力丧失。
（2）耳带状疱疹：耳带状疱疹的特征是耳痛和耳郭或外耳道的红斑水疱，在这种情况下，通常会出现听力损失和头晕等听觉前庭症状，若同时伴有面神经麻痹相关症状，可诊断为拉姆齐-亨特综合征 (Ramsay-Hunt Syndrome, RHS)。RHS 是由于在面神经膝状神经节中潜伏的 VZV 再激活所致，占所有HZ 病例的比例不到 1%，但却多达 1/3 的病人在没有皮疹的情况下发生，其常与贝尔麻痹（特发性面神经麻痹）难以区分，并且可能因多颅神经受累而复杂化。
（3）顿挫型带状疱疹：仅出现红斑、丘疹而不发生水疱。
（4）无疹型带状疱疹：仅出现皮区疼痛而无皮疹。
（5）播散型带状疱疹 (disseminated herpes zoster, DHZ)：在恶性肿瘤或免疫功能极度低下者体内，病毒经血液播散，导致除受累皮节外全身皮肤出现广泛性水疱样疹（≥ 10 个），常伴高热等全身中毒症状，还可出现视网膜炎、急性视网膜坏死及慢性进展性脑炎等并发症，部分 DHZ 病例可合并内脏受累且病死率较高。
（6）中枢神经系统带状疱疹：VZV 侵犯脑实质及脑膜时，可发生病毒性脑炎和脑膜炎，易引起人格改变、意识模糊、头痛、恶心和步态问题。
（7）深型带状疱疹：最常见的非眼部区域是肛周，侵犯内脏神经时可引起胃肠道及泌尿系统症状，表现为腹痛、溃疡、尿潴留、排尿困难等。
（8）复发型带状疱疹：其在免疫正常人群中较为罕见，在免疫抑制者中复发率更高，且与首次发病相比，其发病部位不确定，临床表现及疼痛程度可轻可重。
（9）泛发型带状疱疹：同时累及 2 个及以上神经节，对侧或同侧多个皮节产生皮损。
四、治疗方法
1. 急性期 ZAP 的药物治疗
该阶段治疗目的在于减轻神经刺激，快速抑制急性期疼痛，尽量预防 PHN 发生。
（1）镇痛药物：
对于轻中度疼痛病人，可考虑使用非甾体抗炎药或弱阿片类药物（如布洛芬、曲马多等），对于中重度疼痛病人可考虑使用离子通道调节剂、三环类抗抑郁药、5-HT 和去甲肾上腺素再摄取抑制剂及阿片类药物。非甾体抗炎药包括氟比洛芬酯、布洛芬、塞来昔布、艾瑞昔布等，可发挥镇痛、抗炎等作用；阿片类药物包括羟考酮、吗啡、芬太尼等，可通过与外周和中枢神经系统内的 μ、k 等受体结合抑制外周及中枢敏化；离子通道阻滞剂包括钙离子通道阻滞剂（如加巴喷丁、普瑞巴林）和钠离子通道阻滞剂（如利多卡因），前者通过抑制痛觉过敏与中枢敏化以镇痛、改善睡眠与情感障碍，后者则减少外周神经异常放电达到缓解疼痛的目的；三环类抗抑郁药物适用于控制神经病理性疼痛，包括多塞平、阿米替林等，与离子通道阻滞剂联用可发挥协同作用；5-HT 和去甲肾上腺素再摄取抑制剂通过抑制突触间隙内 5-HT 和去甲肾上腺素的再摄取，进而提高突触间隙内二者的浓度，可抑制疼痛传导途径中下行通路，从而产生镇痛作用（如度洛西汀、文拉法辛）。
（2）糖皮质激素：
在欧洲最新指南中尚未推荐糖皮质激素系统应用于 HZ 急性期疼痛阶段。既往国内皮肤科对于激素使用较为谨慎，但近些年其相关研究也逐渐增加；神经科认为早期使用该药物可快速抑制神经炎症引起的爆发性疼痛；疼痛科则认为对于病情复杂或伴有并发症的病人，早期使用糖皮质激素或许有较好地疗效，而部分免疫抑制者则需禁用该药物。
（3）营养神经药物：
目前临床上普遍认为神经营养药物对缓解神经病理性疼痛有一定作用，主要包括甲钴胺、维生素 B12、牛痘疫苗接种家兔炎症皮肤提取物等。
（4）干扰素 α：
干扰素 α 是由免疫细胞、神经胶质细胞及神经元细胞等合成分泌的一种细胞因子，具有抗病毒、抗肿瘤和免疫调节作用。有研究报道干扰素 α-2b 凝胶（涂抹）或者注射液（肌注）联合抗病毒药物或者椎旁神经注射，可缓解 HZ 病人的疼痛并且可以降低炎症因子水平，但由于样本量不大且相关研究较少，临床上对该方法的疗效还尚未定论。
2. PHN 的药物治疗
当疼痛程度较轻时，单独局部治疗足以解决问题；中重度疼痛可考虑联合全身性药物治疗。
（1）局部治疗：
5% 利多卡因贴剂与辣椒素在美国与欧洲被批准用于治疗 PHN。尽管有效性数据有限，利多卡因仍被认为是一线治疗。一项荟萃分析显示，对于 3 个月以上的慢性疼痛，经30～90 分钟的持续辣椒素治疗后，高浓度的 8% 辣椒素贴剂相较于低浓度 0.075% 辣椒素乳膏疗效更优，但前者具有一定刺激性，部分病人会出现短期的烧灼感或红斑等表现。肉毒杆菌毒素A (botulinum toxin-A, BTX-A) 是一种强效的神经毒素，能够阻断运动神经元和感觉神经元末梢的冲动传递。其常见的不良反应是注射时产生局部疼痛，但可在数小时内缓解。Xiao 等随机对照研究显示，BTX-A皮下注射能够显著缓解 PHN 疼痛且效果优于局部0.5% 利多卡因注射。此外，也有研究显示椎旁神经注射干扰素 α 同样对 PHN 病人有效。
（2）全身治疗：
有证据支持抗惊厥药（加巴喷丁、普瑞巴林）与三环类抗抑郁药（阿米替林）用于治疗 PHN；尽管缺乏有效性证据证明阿片类药物的疗效，但曲马多在临床上应用仍较常见。
3. 微创介入治疗
（1）神经阻滞 (nerve block, NB)：
不同受损神经分布区有不同的阻滞方式，包括周围神经阻滞 (peripheral nerve block, PNB)、三叉神经半月节阻滞、星状神经节阻滞 (stellate ganglion block, SGB)、椎旁神经阻滞 (paravertebral block, PVB) 及硬膜外阻滞等。头面部疱疹阻滞靶点包括眶上、眶下、耳颞、颏神经及枕神经等周围神经，HZ 侵犯三叉神经导致相关疼痛也可以对更深的分支进行阻滞，如上下颌神经甚至到三叉神经半月节。有报道表明SGB 可用于缓解头面部 ZAP，临床上也有 SGB 治疗 RHS 的病例，阻滞成功的标志是病人出现患侧霍纳征（如眼睑下垂、流泪等）表现，其具体机制可能与交感神经功能调节相关。对于颈胸腰段出现的ZAP，选择性 PVB 通过将局部麻醉药物注射至背根神经节 (dorsal root ganglion, DRG) 附近，迅速抑制炎症反应和水肿，阻断痛觉的神经传导通路，以达到同侧受累区域的镇痛效果；对于出现上下肢根性症状的病人，可以选择硬膜外阻滞将局部麻醉药物送至更深的位置甚至硬膜囊外，而少数骶尾会阴区PHN 病人可考虑奇神经节阻滞，该技术适应证广泛，常采用超声等影像定位，强调药物剂量及不良反应的最小化。为应对急性期 ZAP 病程中的“炎症风暴”，临床医师会选择加入少量糖皮质激素与局部麻醉药物混合稀释，通过药物冲击从而达到更直观的治疗效果。
（2）连续射频 (continuous radio frequency, CRF)：
又称射频热凝或标准射频，是利用高频电流产生高温效应，达到神经热损伤的目的。当温度达到41℃～45℃时开始出现神经传导阻滞，超过 60℃时，传导痛温觉的 C 纤维与 Aδ 纤维会发生变性，70℃～75℃时这些神经纤维被破坏但传导触觉的Aα、Aβ 纤维的功能被保存，高于 85℃则无选择的破坏所有神经纤维。
其优点包括操作简单、可操控性强、可选择性大、并发症少且可重复实施。不同于 NB 的药物介导作用，CRF 通过电流热效应进行神经破坏，其对靶点位置要求更精确，更侧重于神经本身的物理性调节，可调控性更高；由于该技术的神经损伤风险，临床上更多的是用于外周神经的调控。
然而，由于 CRF 是一种对组织的热凝损伤，其伴随的并发症包括对邻近神经组织的破坏及长期或永久的感觉和运动功能丧失。因此，为减少医源性问题发生，对于脊神经根或 DRG 等安全性要求更高的部位，国内目前更推荐实施神经调控治疗。
（3）脉冲射频 (pulsed radiofrequency, PRF)：
不同于 CRF 的热效应，PRF 通过场效应来发挥作用。射频仪间断发出脉冲式电流，传导至针尖前方，在神经组织附近形成高电压激活神经元，改变神经电位传导状态，但电极尖端温度不超过 42℃，因此不会破坏感觉运动神经功能。PRF 的潜在机制涉及通过抑制伤害性 C 纤维，从而长期抑制从外周到中枢神经系统的疼痛信号。此外，脊髓背角水平小胶质细胞失活、促炎细胞因子减少、内源性阿片类药物前体信使核糖核酸增加、去甲肾上腺素能和 5-HT能下行疼痛抑制途径的增强、A-δ 纤维的轻微损伤已被发现有助于减轻 PRF 应用后的疼痛。
相较于标准 PRF，高电压长时程 PRF 治疗效果更优。Song 等的研究结果提示高电压 PRF 近期与远期效果均优于标准 PRF，而 Wen 等研究表明 2 次重复高电压长时程 PRF 可有效缓解急性期疱疹痛。该技术不仅具有传统 CRF 的优点，还能通过使用间断的脉冲电刺激神经系统，避免传统 CRF 可能带来的热损伤，减少对神经组织的损害，提高了治疗的安全性，更推荐于 DRG 及三叉神经节等部位 ZAP。极少数骶尾会阴区疱疹痛病人可考虑行骶神经联合奇神经节 PRF，效果更佳。
（4）神经电刺激：
神经电刺激通过植入电极刺激神经产生麻木感以达到缓解疼痛的目的，临床上常用的包括脊髓电刺激 (spinal cord stimulation, SCS)、周围神经电刺激 (peripheral nerve stimulation, PNS)、经皮神经电刺激 (transcutaneous electric nerve stimulation, TENS) 三种神经调控式。
有研究表明，SCS、PNS、TENS 均可以诱导 ZAP 病人的皮质 α 振荡变化，这种动态变化可能在一定程度上介导植入式神经电刺激对 ZAP 的镇痛作用。SCS 通过影像定位将电极植入硬膜外腔，电极产生电流作用于脊髓背角感觉神经元和脊髓侧角交感神经中枢，减少神经痛觉信号传递，抑制或关闭引起疼痛电位变化的门控通道；另一方面，持续电流可以增加中枢阿片类受体的表达，抑制内源性阿片类物质的释放，从而达到镇痛效果。陈燕中等研究发现 SCS 在1、3及7周时对 ZAP的治疗效果均优于 PRF 且差异有统计学意义。
PNS 同样通过影像引导，定位确切后将电极植入皮下外周神经旁，多适用于 HZO 病人及顶枕部ZAP 等。PNS 抗伤害性作用的机制尚不清楚。既往的神经影像学研究表明，其可能干扰伤害性输入信号的高阶加工，例如通过加强疼痛的下行抑制通路。PNS 也可能促进内源性内啡肽和其他类鸦片物质的释放增加，使神经传导速度恢复正常，并降低传导潜伏期。目前仍需要进一步的临床研究来阐明 PNS的病理生理及作用机制。国内外已有多项研究表明PNS 能够有效治疗 ZAP。
TENS 是通过皮肤将特定的低频脉冲电流输入人体，反馈性的进行神经调节，减少疼痛信息的传导和增加疼痛相关物质的释放，进而缓解疼痛。其操作较前两者更简单，创伤相对更小。Mokhtari 等关于 TENS 的机制与应用综述中明确指出其在 ZAP中的应用。
（5）联合治疗：
对于顽固性的 ZAP 以及 PHN等采用单一手段治疗效果不佳，可以考虑多方式联合治疗。在一项 201 例顽固性 ZAP 病人治疗的随机对照研究中，高谦等研究发现 PRF 联合 NB 的短期及远期效果明显优于任意单一治疗方式。Ma等和 Liu 等研究发现 PNS 联合三叉神经半月节 PRF 或是与眶上神经 PRF 交叉调控皆优于单独进行 PNS，且远期疗效显著。
（6）中枢靶控输注：
也称鞘内泵注射，是指将镇痛药物直接给到椎管内作用于脊髓和大脑中枢神经系统，通过阻断或抑制脊髓后角疼痛信号的传导，从而达到较强的镇痛效果，该方法往往适用于顽固性 HZ 疼痛病人。
4. 其他治疗
（1）物理治疗：
常见的物理治疗手段包括光疗、三氧治疗及低温冲击波疗法。相对于传统的红外线照射光疗，近年来新涌现出的碳素光和半导体激光疗法在抑制炎症反应以缓解疼痛方面的效果则更为显著。三氧治疗的优势在于能够消除致痛因子和促进神经修复，而低温冲击疗法则利用低温刺激阻断了痛觉信号通路的传导。
（2）中医治疗：
中医治疗主要依赖中药，包括中药的口服、外敷与针灸，可以疏通经脉，调节气血，调和脏腑，增强免疫力，从而缩短疼痛持续时间和防治疾病。
（3）心理治疗：
近年来，随着对 PHN 病理生理机制进一步了解，已有研究证实了认知行为疗法、正念疗法、健康宣教及心理支持等心理干预治疗此类慢性疼痛的价值。
五、总结与展望
ZAP 是临床上的常见病，其中 PHN 更是一类令人头疼的顽固性慢性疾病。区域、性别、季节性变化等因素对该病的群体分布影响尚不明确，然而随着人口的老龄化及免疫功能降低，其发病率在未来将持续增长。ZAP 的发病机制比较复杂，以中枢敏化与外周敏化为关键，不同病程可能存在多种机制交叉，神经胶质细胞、神经元修复等药物靶点可能是未来的研究方向。由于经济状况不同，国外发达国家致力于 HZ 疫苗的研发以期降低发病率，对于已受疼痛困扰的病人其治疗研究证据相对较少，其中以抗病毒药物治疗更为常见。相对而言，我国人口基数大，老龄化严重，ZAP 发病率高，因此更侧重于治疗方面的研究。镇痛药、激素、神经营养药以及生物因子等体现了药物治疗的多样性，肋间、椎旁、神经节及硬膜外等靶点体现了 NB 治疗的多样性，射频、神经电刺激等微创介入手段则提供了更好地选择。尽管目前国内对于 ZAP 的治疗已达成部分共识，但不同病程阶段尤其是 PHN 时期或是 HZO、RHS 等特殊类型 ZAP 的治疗，尚缺乏足够的研究证明某种治疗方式孰优孰劣。目前也发现一些药物、物理手段及微创介入之间相互联合治疗的研究，其中大多得到了较高的病人满意度。
综上所述，PHN 及特殊类型 ZAP 的防治仍是未来的关注重点，在不断深入了解发病机制的基础上，需要不断更新并规范有效的治疗手段。或许，基于疾病本身的个体化方案和多模式联合镇痛能够为该病的临床治疗提供新思路。
来源：叶国强 鄢 毅 张达颖.带状疱疹相关性疼痛的研究进展[J].中国疼痛医学杂志,2025,31(6):461~466
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疫苗临床研究临床结果
100 项与 加巴喷丁 相关的药物交易
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 周围神经痛 | 比利时 | 2006-10-27 | |
| 周围神经痛 | 捷克 | 2006-10-27 | |
| 周围神经痛 | 法国 | 2006-10-27 | |
| 周围神经痛 | 德国 | 2006-10-27 | |
| 周围神经痛 | 匈牙利 | 2006-10-27 | |
| 周围神经痛 | 冰岛 | 2006-10-27 | |
| 周围神经痛 | 爱尔兰 | 2006-10-27 | |
| 周围神经痛 | 意大利 | 2006-10-27 | |
| 周围神经痛 | 拉脱维亚 | 2006-10-27 | |
| 周围神经痛 | 卢森堡 | 2006-10-27 | |
| 周围神经痛 | 荷兰 | 2006-10-27 | |
| 周围神经痛 | 挪威 | 2006-10-27 | |
| 周围神经痛 | 波兰 | 2006-10-27 | |
| 周围神经痛 | 葡萄牙 | 2006-10-27 | |
| 周围神经痛 | 斯洛文尼亚 | 2006-10-27 | |
| 周围神经痛 | 瑞典 | 2006-10-27 | |
| 周围神经痛 | 英国 | 2006-10-27 | |
| 疱疹后神经痛 | 美国 | 2000-03-02 | |
| 焦虑症 | 日本 | 1993-12-30 | |
| 咳嗽 | 日本 | 1993-12-30 |
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 消化不良 | 临床3期 | 美国 | 2010-03-01 | |
| 难治性慢性咳嗽 | 临床3期 | 澳大利亚 | 2008-10-15 | |
| 潮热 | 临床3期 | 美国 | 2008-09-01 | |
| 血管舒缩症 | 临床3期 | 美国 | 2008-09-01 | |
| 入睡和睡眠障碍 | 临床3期 | 美国 | 2004-10-01 | |
| 震颤 | 临床3期 | 美国 | 2004-03-01 | |
| 腕管综合征 | 临床3期 | 中国香港 | 2003-10-01 | |
| 肌萎缩侧索硬化 | 临床3期 | 美国 | 1999-12-31 | |
| 唇疱疹 | 临床1期 | 比利时 | 2008-07-01 | |
| 尿毒症瘙痒 | 临床阶段不明 | 中国 | 2005-10-01 |
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| 研究 | 分期 | 人群特征 | 评价人数 | 分组 | 结果 | 评价 | 发布日期 |
|---|
N/A | 500 | 顧齋範廠鏇衊築遞鹽觸(壓鏇鹹憲淵鏇鏇簾獵築) = 醖鹽憲衊遞蓋繭襯獵遞 膚鬱範積遞簾壓衊餘襯 (衊衊選範鹹顧網蓋鏇積 ) 更多 | 不佳 | 2025-10-24 | |||
临床4期 | 110 | Gabapentin Placebo (Placebo) | 糧顧憲淵選鑰鑰繭遞獵(鏇膚範鑰夢選簾觸網鬱) = 鹹鑰糧構鏇範夢鏇網廠 願壓網製範淵鏇網窪醖 (繭選網衊顧憲簾獵積鹹, 鑰鏇壓遞鏇願觸鹽鹽窪 ~ 網鹹構艱艱憲築餘觸網) 更多 | - | 2025-08-12 | ||
(Intervention) | 糧顧憲淵選鑰鑰繭遞獵(鏇膚範鑰夢選簾觸網鬱) = 淵顧蓋醖襯願壓觸獵夢 願壓網製範淵鏇網窪醖 (繭選網衊顧憲簾獵積鹹, 窪繭夢衊獵糧艱襯襯積 ~ 襯淵構獵範艱鑰衊醖願) 更多 | ||||||
临床4期 | 58 | 憲鹹窪壓鹽鏇構窪憲觸 = 鹽鹽壓夢夢鬱蓋襯艱窪 願齋鑰願淵觸顧願夢繭 (襯築醖齋觸遞繭鹽窪鏇, 鬱鹹觸鏇選選窪夢衊願 ~ 憲積廠壓糧鹽壓觸餘鹹) 更多 | - | 2025-07-08 | |||
憲鹹窪壓鹽鏇構窪憲觸 = 窪鏇繭廠夢鬱齋壓襯夢 願齋鑰願淵觸顧願夢繭 (襯築醖齋觸遞繭鹽窪鏇, 齋衊鏇鬱憲衊鑰築遞鹽 ~ 鹹淵膚膚積網鹹獵繭壓) 更多 | |||||||
N/A | - | 145 | Patient-controlled analgesia (PCA) with intravenous opioids | - | 积极 | 2025-05-14 | |
積廠鹹艱製糧夢範構醖(窪淵襯獵醖蓋襯壓蓋膚) = 糧艱淵製鹹膚艱繭窪廠 鏇鑰築遞壓糧觸窪襯觸 (觸網鏇衊願積選選壓製 ) 更多 | |||||||
临床4期 | 48 | (Standard Protocol) | 繭膚膚壓齋廠繭築鹽觸(繭鹹淵鬱齋願觸夢範夢) = 鹹願簾壓築選醖壓憲廠 廠糧餘鏇獵選膚齋淵鹹 (獵壓製構遞遞鑰繭壓構, 襯獵鹽衊鹹顧膚鏇遞窪 ~ 願顧製網襯鏇壓蓋鬱鑰) 更多 | - | 2024-09-19 | ||
(Enhanced Recovery Protocol) | 繭膚膚壓齋廠繭築鹽觸(繭鹹淵鬱齋願觸夢範夢) = 繭齋鬱糧積遞繭簾遞鑰 廠糧餘鏇獵選膚齋淵鹹 (獵壓製構遞遞鑰繭壓構, 築憲網網醖築製鹽觸淵 ~ 遞築鹹膚鑰選齋鹹構鬱) 更多 | ||||||
临床1/2期 | - | Gabapentin 300mg TID | 繭艱鹹願醖鬱襯選繭醖(齋製憲鏇膚獵願廠網膚) = 製觸願鏇繭範餘遞鬱獵 鹽鹹壓壓願憲鹹顧鑰構 (獵餘窪鏇蓋鑰製遞醖餘 ) | - | 2024-05-24 | ||
Intranasal Ketamine 30mg TID | 繭艱鹹願醖鬱襯選繭醖(齋製憲鏇膚獵願廠網膚) = 鹹繭憲鹹艱鏇窪觸壓壓 鹽鹹壓壓願憲鹹顧鑰構 (獵餘窪鏇蓋鑰製遞醖餘 ) | ||||||
N/A | 56 | Acupuncture (True Acupuncture) | 齋遞選餘餘築壓鏇繭衊(遞願夢獵壓艱製憲鹹淵) = 願齋餘淵鏇憲憲製醖壓 糧鹽鬱蓋顧築窪遞製窪 (顧鏇窪構築醖構願構網, 5.01) 更多 | - | 2024-04-23 | ||
Sham Acupuncture (Sham Acupuncture) | 齋遞選餘餘築壓鏇繭衊(遞願夢獵壓艱製憲鹹淵) = 夢蓋鏇憲淵鬱膚壓衊鏇 糧鹽鬱蓋顧築窪遞製窪 (顧鏇窪構築醖構願構網, 2.44) 更多 | ||||||
临床2期 | 70 | (Post-Operative Non Opioid Pain Protocol) | 選獵繭鹹觸範齋醖憲鏇(願願蓋網觸鹽鬱顧鹽觸) = 鹹繭遞糧憲襯衊範淵廠 網獵遞蓋鹹憲壓築襯獵 (遞觸構糧製鑰夢積簾窪, 2.1) 更多 | - | 2024-04-02 | ||
(Post-Operative Traditional Pain Protocol) | 選獵繭鹹觸範齋醖憲鏇(願願蓋網觸鹽鬱顧鹽觸) = 選壓選構製醖餘醖憲齋 網獵遞蓋鹹憲壓築襯獵 (遞觸構糧製鑰夢積簾窪, 1.8) 更多 | ||||||
临床3期 | 20 | (No Gabapentin) | 廠範憲鏇淵構鑰衊膚願(窪鏇衊艱蓋糧餘窪餘襯) = 糧繭簾齋顧夢積淵顧繭 遞築廠襯鏇選築齋夢網 (鬱鑰簾簾齋築壓壓築廠, 遞製膚鑰繭獵壓壓鏇選 ~ 遞夢膚鏇製艱衊積製網) 更多 | - | 2024-03-21 | ||
(300 mg Gabapentin 3X Per Day) | 廠範憲鏇淵構鑰衊膚願(窪鏇衊艱蓋糧餘窪餘襯) = 衊願蓋衊衊觸廠範網積 遞築廠襯鏇選築齋夢網 (鬱鑰簾簾齋築壓壓築廠, 繭鏇鏇蓋鏇糧壓窪積齋 ~ 網襯醖憲窪憲網窪衊遞) 更多 | ||||||
临床2期 | 54 | (N-Acetylcysteine) | 蓋餘壓衊憲積夢餘鹽蓋(獵餘淵範鹹艱鹹襯築蓋) = 鹹憲鏇糧繭鹹齋糧鹹製 衊憲糧鏇顧窪繭淵壓繭 (鏇簾艱鏇鹽積憲艱鹹鏇, 0.543) 更多 | - | 2023-12-13 | ||
(Gabapentin) | 蓋餘壓衊憲積夢餘鹽蓋(獵餘淵範鹹艱鹹襯築蓋) = 衊鑰壓鏇衊淵構遞憲選 衊憲糧鏇顧窪繭淵壓繭 (鏇簾艱鏇鹽積憲艱鹹鏇, 0.646) 更多 |
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