Phase IV Study of the Pharmacokinetics of Long-Acting Injectable Cabotegravir and Rilpivirine in Pregnant and Postpartum Women With HIV in the United States

Phase IV, multi-site, open-label, non-randomized study of the pharmacokinetics (PK) of long-acting injectable cabotegravir and rilpivirine (CAB LA + RPV LA) during pregnancy and postpartum.

开始日期2026-07-15

申办/合作机构

National Institute of Mental Health

[+1]

NCT07650916

/ Not yet recruiting临床3期

A Phase III, Randomized, Multicenter, Parallel-group, Non-inferiority, Open-label Study Evaluating the Efficacy, Safety, and Tolerability of Cabotegravir Ultra Long-acting Plus Rilpivirine Ultra Long-acting or Cabotegravir Long-acting Plus Rilpivirine Long-acting in Adults and Adolescents With HIV Who Are Virologically Suppressed on ART

This study compares the efficacy, safety and tolerability of CAB ULA and RPV ULA administered with CAB long acting (LA) and RPV LA administered in adults and adolescents with HIV who are virologically suppressed on anti-retroviral therapy (ART).

开始日期2026-06-29

申办/合作机构

ViiV Healthcare Ltd.

NCT07637877

/ Recruiting临床2期IIT

Targeted Therapies for Immunological Non-Responders in People With HIV: A Multicenter Clinical Study

This study focuses on people with HIV who experience incomplete immune reconstitution despite suppressive antiretroviral therapy (ART), characterized by persistently low CD4⁺ T cell counts and residual inflammation. The underlying cause is largely attributed to the persistent HIV latent reservoir. Recent evidence indicates that rilpivirine, a non-nucleoside reverse transcriptase inhibitor (NNRTI) commonly used in ART, has an immunomodulatory function beyond its antiviral activity. It activates the CARD8 inflammasome - an intracellular "kill switch" - triggering pyroptosis selectively in HIV-infected cells. In this study, rilpivirine will be added to suppressive ART in patients with incomplete immune reconstitution. The investigators hypothesize that this strategy will reduce the latent reservoir, restore CD4⁺ T cell counts and function, attenuate excessive immune activation, and ultimately improve long-term clinical outcomes.

开始日期2026-06-15

申办/合作机构

广州医科大学附属市八医院（广州市第八人民医院、广州市肝病医院、广州市传染病研究所）

[+1]

100 项与盐酸利匹韦林相关的临床结果

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100 项与盐酸利匹韦林相关的转化医学

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100 项与盐酸利匹韦林相关的专利（医药）

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1,960

项与盐酸利匹韦林相关的文献（医药）

2026-12-31·HIV Research & Clinical Practice

Successful initiation of fully parenteral antiretroviral therapy in a treatment-naïve person with HIV-1 infection and intestinal failure

Article

作者: Sram, Krystof ; Lhotan, Jakub ; Jilich, David ; Sevela, Stanislav ; Rozsypal, Hanus

INTRODUCTION:

In patients with severe surgical and gastrointestinal complications, standard oral combination antiretroviral therapy (ARV) may be temporarily impossible. Long-acting cabotegravir/rilpivirine (CAB/RPV LA) is approved for virologically suppressed individuals pretreated with oral therapy, but data on its use in treatment-naïve, critically ill patients with absent enteral absorption are extremely limited.

CLINICAL PRESENTATION:

We report a 26-year-old male admitted with fulminant hypertriglyceridaemic necrotizing pancreatitis complicated by abdominal compartment syndrome, multiple laparotomies, open abdomen with enteric fistulae, short bowel syndrome type I, chronic intestinal failure requiring parenteral nutrition, portal vein thrombosis, and prolonged intensive care. HIV-1 infection was diagnosed early (HIV RNA 5,000 copies/mL; CD4+ 780 cells/µL). Within three months, HIV RNA rose to 320,000 copies/mL and CD4+ declined to 570 cells/µL. Given absent gastrointestinal passage, standard ARV was initially deferred, but rapid virological rebound necessitated urgent treatment. An off-label fully parenteral regimen was initiated: intravenous zidovudine (AZT) with intramuscular CAB/RPV LA. Therapy was well tolerated alongside surgery, parenteral nutrition, antimicrobials, and anticoagulation. HIV RNA decreased to <20 copies/mL within 65 days and remained suppressed, with CD4+ recovery. Intravenous AZT was discontinued after 35 days, and CAB/RPV LA continued as maintenance during recovery and home parenteral nutrition.

DISCUSSION:

Fully parenteral ARV, including CAB/RPV LA, may provide a safe and effective bridge to durable viral suppression in patients with absolute contraindications to oral therapy, warranting further evaluation.

2026-07-01·INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Virological outcomes of PWH who discontinued cabotegravir/rilpivirine long-acting therapy in a real-world context

Article

作者: Gagliardini, Roberta ; Marchetti, Giulia ; Squillace, Nicola ; Giacomelli, Andrea ; Monforte, Antonella d'Arminio ; Antinori, Andrea ; Raccagni, Angelo Roberto ; Muccini, Camilla ; Bana, Nicholas Brian ; Mazzotta, Valentina ; Tavelli, Alessandro ; Saracino, Annalisa

OBJECTIVES:

The aim of this study was to describe virological outcomes in people with HIV (PWH) after discontinuation of long-acting (LA) cabotegravir (CAB) plus rilpivirine (RPV).

METHODS:

All PWH enrolled in the Icona Cohort who discontinued CAB/RPV LA and had at least one follow-up after discontinuation were included.

RESULTS:

A total of 84 out of 805 (10.4%) PWH discontinued CAB/RPV, mainly due to toxicity or adverse events (67.9%). Most individuals (72.6%) returned to the same oral antiretroviral regimen used prior LA therapy. The 12-month cumulative probability of discontinuing oral ART after CAB/RPV was 19.9% (95% confidence interval [CI] 11.9-32.2%). After switching back to oral ART all individuals except one maintained or achieved HIV RNA levels below 50 copies/mL.

CONCLUSION:

These findings suggest that PWH who discontinue LA CAB/RPV and resume oral ART maintain or achieve high rates of virologic suppression.

2026-07-01·JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Brief Report: Real-World Uptake and Clinical Outcomes of Long-Acting Injectable Cabotegravir/Rilpivirine in the United States, 2021–2023

Article

作者: Kourtis, Athena P ; Briggs-Hagen, Melissa ; O'Shea, Jesse ; Iqbal, Kashif ; Derton, Abigail ; Henson, James ; Buchacz, Kate

Background::

Long-acting injectable antiretroviral therapy offers an alternative to daily oral regimens for people with HIV. We assessed national uptake and characteristics of persons prescribed injectable cabotegravir/rilpivirine (CAB/RPV) in the United States from 2021 to 2023.

Methods::

We conducted a retrospective cohort study using HealthVerity Marketplace, a national claims database with pharmacy, medical, and laboratory data. People with HIV with ≥1 closed, approved prescription claim for CAB/RPV or oral ART were identified. Demographic, clinical, and payer characteristics, viral load (VL), and CD4 counts were examined.

Results::

From 2021 to 2023, 4087 individuals were prescribed CAB/RPV (21,698 prescriptions), comprising 1.3% of all ART prescriptions by 2023. CAB/RPV recipients were more likely to be aged 25–44 and enrolled in Medicaid. CAB/RPV prescribing was disproportionately low in the Southern United States and among adults 55 years and older, despite higher HIV prevalence in these groups. Among individuals with a detectable VL at initiation (52.2%), 7.2% had viremia (≥200 copies/mL). Among those with ≥1 follow-up VL (n = 2234), 1.8% experienced confirmed virologic failure, defined as ≥2 VLs ≥200 copies/mL. CD4 counts remained stable, with median values near 700 cells/mm 3 pre- and postinitiation.

Conclusion::

While CAB/RPV uptake is increasing, its use remains modest and uneven. High rates of virologic suppression support its real-world effectiveness, but disparities by age, region, and payer point to persistent barriers. Continued real-world monitoring and targeted implementation strategies are critical to fully realizing the potential of long-acting injectable ART.

390

项与盐酸利匹韦林相关的新闻（医药）

2026-06-24

·北京医学感染与传染研究

抗菌化疗杂志81卷 1-6期、增刊1期（2026年6月24日更新）

Journal of Antimicrobial Chemotherapy Volume 81, Issue 1抗菌化疗杂志81卷 1期 https://academic.oup.com/jac/issue 50th Anniversary Collection（50周年纪念合集） Review（综述） 1 Artificial intelligence for improving decision-making in bacterial infection management: a narrative review 人工智能在改善细菌感染治疗决策中的应用：一项叙述性综述 Anisia Talianu and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf470, https://doi.org/10.1093/jac/dkaf470 Reviews（综述） 2 Evolving landscape of methicillin-resistant Staphylococcus pseudintermedius: the emergence of new epidemic waves across Europe, Asia and North America 耐甲氧西林中间型葡萄球菌的演变格局：欧洲、亚洲和北美洲新流行浪潮的出现 Lillian Rose Giarratana and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf340, https://doi.org/10.1093/jac/dkaf340 3 Azithromycin resistance in non-typhoidal Salmonella: a review 非伤寒沙门氏菌对阿奇霉素的耐药性：综述 Zhe Zhu and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf341, https://doi.org/10.1093/jac/dkaf341 4 Antibiotic pharmacodynamics: from MIC to advanced metrics and their applications 抗生素药效动力学：从最低抑菌浓度到高级指标及其应用 Malin Andersson and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf374, https://doi.org/10.1093/jac/dkaf374 5 Progress in the study of drug resistance mechanism of Bacillus cereus 蜡样芽孢杆菌耐药机制研究进展 Yuhang Zhang and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf399, https://doi.org/10.1093/jac/dkaf399 6 The curious constraints on clofazimine 氯法齐明的奇特限制 Maple Goh and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf430, https://doi.org/10.1093/jac/dkaf430 7 Antiplasmid systems: a novel strategy to combat antibiotic resistance 抗质粒系统：对抗抗生素耐药性的新策略 Mohd Asim and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf472, https://doi.org/10.1093/jac/dkaf472 Systematic Review（系统综述） 8 Coccidioidomycosis in Europe: a systematic literature review of epidemiology, treatment and outcomes 欧洲球孢子菌病：流行病学、治疗和预后的系统文献综述 Priya Shastri and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf407, https://doi.org/10.1093/jac/dkaf407 9 Systematic review of antimicrobial pharmacokinetic/pharmacodynamic indices in murine thigh and hollow fibre dose fractionation studies analysed with a standard method 用标准方法分析小鼠大腿和空心纤维剂量分次研究中的抗菌药物药代动力学/药效动力学指数的系统综述 Najla Alabdulkarim and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf446, https://doi.org/10.1093/jac/dkaf446 Virtual Roundtable（虚拟圆桌会议） 10 Procalcitonin in the management of lower respiratory tract infection and sepsis 降钙素原在下呼吸道感染和败血症治疗中的应用 Ramy H Elshaboury and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf298, https://doi.org/10.1093/jac/dkaf298 Original Research（论著） 11 Model-based assessment of letermovir pharmacokinetics in allogeneic haematopoietic stem cell transplant recipients 来特莫韦在异基因造血干细胞移植受者中药代动力学的基于模型的评估 Chrisoula Tahtsidou and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf427, https://doi.org/10.1093/jac/dkaf427 12 In vitro exebacase (CF-301) activity against methicillin-susceptible or methicillin-resistant Staphylococcus aureus and coagulase-negative staphylococci strains isolated from patients with infective endocarditis 体外试验评估依拉环素（CF-301）对甲氧西林敏感或甲氧西林耐药金黄色葡萄球菌及凝固酶阴性葡萄球菌（从感染性心内膜炎患者中分离）的活性 María-Alexandra Cañas and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf435, https://doi.org/10.1093/jac/dkaf435 13 Evaluation of subcutaneous amoxicillin/clavulanic acid pharmacokinetics as an alternative to the intravenous route in older patients—the PhASAge Study 评估皮下注射阿莫西林/克拉维酸药代动力学作为老年患者静脉给药替代方案——PhASAge研究 Nicolas Grégoire and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf381, https://doi.org/10.1093/jac/dkaf381 14 Real-life use of isavuconazole in Spanish children and adolescents 西班牙儿童和青少年中艾沙康唑的实际使用情况 Natalia Mendoza-Palomar and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf394, https://doi.org/10.1093/jac/dkaf394 15 No pharmacovigilance signal of intracranial hypertension associated with glycylcyclines: a FAERS-based disproportionality analysis 基于FAERS数据库的不成比例性分析：未发现甘氨酰环素类与颅内高压相关的药物警戒信号 Slobodan M Jankovic and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf395, https://doi.org/10.1093/jac/dkaf395 16 Posaconazole enteral tube administration in adults: pharmacokinetic target attainment of oral suspension compared with crushed delayed-release tablet 成人经肠内营养管给予泊沙康唑：口服混悬液与碾碎的缓释片的药代动力学目标达成情况比较 Nirjan Bhattarai and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf396, https://doi.org/10.1093/jac/dkaf396 17 Characterizing CYP3A4-mediated drug interactions: a fixed-sequence pharmacokinetic Chinese study of posaconazole and ruxolitinib in haematological malignancies CYP3A4介导的药物相互作用特征：一项关于泊沙康唑和鲁索替尼在血液系统恶性肿瘤中的固定序列药代动力学中国研究 Beibei Liang and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf398, https://doi.org/10.1093/jac/dkaf398 18 Differences in prescription for impetigo and cellulitis across years in three European countries 三个欧洲国家不同年份脓疱病和蜂窝织炎的处方差异 Thomas Bettuzzi and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf400, https://doi.org/10.1093/jac/dkaf400 19 β-Lactam concentrations monitored in the early phase of community-acquired sepsis in the intensive care unit 重症监护室社区获得性脓毒症早期阶段监测的β-内酰胺浓度 Karolina Liljedahl Prytz and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf401, https://doi.org/10.1093/jac/dkaf401 20 Enhanced antimycobacterial efficacy of simulated inhaled clofazimine versus oral clofazimine in combination with azithromycin and ethambutol in a hollow-fiber system 在空心纤维系统中，模拟吸入氯法齐明与口服氯法齐明联合阿奇霉素和乙胺丁醇的抗结核分枝杆菌疗效增强比较 Jelmer Raaijmakers and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf402, https://doi.org/10.1093/jac/dkaf402 21 Identification of antimicrobial resistance genes in Escherichia coli through network diffusion 通过网络扩散法鉴定大肠杆菌中的抗生素耐药基因 Anis Mansouri and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf404, https://doi.org/10.1093/jac/dkaf404 22 Preclinical evaluation of epetraborole in the hollow fibre system model of Mycobacterium abscessus lung disease 依培硼罗在脓肿分枝杆菌肺病空心纤维系统模型中的临床前评估 Sanjay Singh and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf405, https://doi.org/10.1093/jac/dkaf405 23 The β-lactamase inhibitor concentration-dependent minimum inhibitory concentration (MICcBLI) as methodology to assess the pharmacokinetic/pharmacodynamic relationship of piperacillin/tazobactam for dosing optimization β-内酰胺酶抑制剂浓度依赖性最低抑菌浓度（MICcBLI）作为评估哌拉西林/他唑巴坦药代动力学/药效动力学关系以优化给药的方法 Malin Andersson and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf406, https://doi.org/10.1093/jac/dkaf406 24 Unravelling the triad of penicillin-binding proteins, β-lactamase activity, and mRNA dynamics in Pseudomonas aeruginosa AmpC induction 解析铜绿假单胞菌AmpC诱导过程中青霉素结合蛋白、β-内酰胺酶活性和mRNA动态的三元关系 Maria Montaner and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf408, https://doi.org/10.1093/jac/dkaf408 25 Unnoticed spread of linear VanA-plasmids in vancomycin-variable Enterococcus faecium strains across different regions: a diagnostics challenge 不同地区万古霉素可变型粪肠球菌菌株中线性VanA质粒的未被察觉的传播：一项诊断挑战 Ana C Almeida-Santos and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf409, https://doi.org/10.1093/jac/dkaf409 26 Switching from etravirine to doravirine in virologically suppressed people with HIV: results from the French multicentre SWEED observational study 在病毒学抑制的HIV感染者中从依曲韦林切换至多拉韦林：法国多中心SWEED观察性研究的结果 Romain Palich and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf410, https://doi.org/10.1093/jac/dkaf410 27 HIV-1 drug resistance among pregnant and breastfeeding mothers and its association with paediatric HIV infections in the Dolutegravir era in Uganda 乌干达多替拉韦时代孕产妇及哺乳期母亲中HIV-1耐药情况及其与儿童HIV感染的关联 Anne Kapaata and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf411, https://doi.org/10.1093/jac/dkaf411 28 Outpatient antibiotic prescribing for medically attended respiratory syncytial virus, influenza, or human metapneumovirus illness among high-risk adults in rural Wisconsin, United States 美国威斯康星州农村地区高风险成人因呼吸道合胞病毒、流感或人偏肺病毒感染就诊时的门诊抗生素处方情况 Sarah C J Jorgensen and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf412, https://doi.org/10.1093/jac/dkaf412 29 Omadacycline as a drug candidate for Mycobacterium avium infections: in vitro insights on single and combination therapies 奥马环素作为鸟分枝杆菌感染候选药物：单药及联合治疗的体外研究 Saskia E Mudde and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf413, https://doi.org/10.1093/jac/dkaf413 30 Post-pandemic trends in Streptococcus pneumoniae serotype epidemiology and antibiotic susceptibility in adults with invasive and non-invasive pneumococcal disease in the USA (2022–2023) 后疫情时代美国成人侵袭性与非侵袭性肺炎链球菌病血清型流行病学及抗生素敏感性趋势（2022-2023） Mekki F Bensaci and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf414, https://doi.org/10.1093/jac/dkaf414 31 Benznidazole pharmacokinetics in patients with chronic Chagas disease: association with demographic factors and adverse drug reactions 慢性恰加斯病患者苯芴醇药代动力学：与人口统计学因素及药物不良反应的关联 Gabriel P E Silveira and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf416, https://doi.org/10.1093/jac/dkaf416 32 Acquired antimicrobial resistance genes in Bordetella Species: a global genomic analysis 博德特氏菌属中获得的抗菌药物耐药基因：全球基因组分析 Biao Tang and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf418, https://doi.org/10.1093/jac/dkaf418 33 Machine learning for personalized antimicrobial susceptibility breakpoints: (Adaptive clinical breakpoint interpretation) 基于机器学习的个性化抗菌药物敏感性折点制定（自适应临床折点解释） Yinzheng Zhong and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf419, https://doi.org/10.1093/jac/dkaf419 34 Multicentre investigation of Wickerhamomyces anomalus fungemia in India: emerging resistance and mechanistic insights 印度异常威克汉姆酵母菌血症的多中心研究：新发耐药性及机制洞察 Shristi Verma and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf420, https://doi.org/10.1093/jac/dkaf420 35 Reducing aztreonam/avibactam waste: insights from Monte Carlo simulations 减少氨曲南/阿维巴坦浪费：蒙特卡洛模拟的启示 Yeleen Fromage and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf421, https://doi.org/10.1093/jac/dkaf421 36 Nanoparticle-based co-delivery of ciprofloxacin and meropenem enhances synergistic activity against multidrug-resistant hypervirulent Klebsiella pneumoniae clinical isolates 基于纳米颗粒的环丙沙星与美罗培南共递送可增强对多重耐药高毒力肺炎克雷伯菌临床分离株的协同活性 Reham Mostafa and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf422, https://doi.org/10.1093/jac/dkaf422 37 Development of population pharmacokinetic models of total and free piperacillin in critically ill children and young adults for Monte Carlo simulations and model-informed precision dosing 危重症儿童及青年总游离哌拉西林群体药代动力学模型开发：用于蒙特卡洛模拟及模型引导的精准给药 Sonya Tang Girdwood and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf423, https://doi.org/10.1093/jac/dkaf423 38 Reaching the target: time and dose required to achieve target vancomycin plasma concentrations in admitted patients 达标分析：住院患者达到目标万古霉素血浆浓度所需的时间与剂量 W Töpfer and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf424, https://doi.org/10.1093/jac/dkaf424 39 Notable transmitted HIV drug resistance among people who inject drugs in Pakistan 巴基斯坦注射毒品人群中显著传播的HIV耐药性 Stephanie Melnychuk and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf425, https://doi.org/10.1093/jac/dkaf425 40 Synergistic but clinically unattainable: amoxicillin/ceftriaxone combination against ampicillin-susceptible Enterococcus faecium 协同但临床难以实现：阿莫西林/头孢曲松联合对氨苄西林敏感粪肠球菌的体外活性 Ahmed Ashrin and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf426, https://doi.org/10.1093/jac/dkaf426 41 Pharmacodynamic studies of taniborbactam (VNRX-5133) combined with cefepime against β-lactamase–producing Gram-negative bacteria in a neutropenic murine thigh infection model 中性粒细胞减少小鼠大腿感染模型中他尼硼巴坦（VNRX-5133）联合头孢吡肟对产β-内酰胺酶革兰氏阴性菌的药效动力学研究 Panagiota-Christina Georgiou and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf431, https://doi.org/10.1093/jac/dkaf431 42 Epidemiology and treatment of endocarditis secondary to Enterobacterales other than Serratia spp. 非塞拉蒂亚属肠杆菌目细菌所致心内膜炎的流行病学及治疗 Clayton F Hausberger and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf432, https://doi.org/10.1093/jac/dkaf432 43 Enhanced activity of apramycin and apramycin-based combinations against Mycobacteroides abscessus 阿普拉霉素及其组合对脓肿分枝杆菌的增强活性 Yanqin Huang and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf433, https://doi.org/10.1093/jac/dkaf433 44 Efflux-mediated multidrug resistance mechanism in Trichophyton indotineae and Trichophyton rubrum; role of ABC transporters and MFS gene 印度毛癣菌与红色毛癣菌中由ABC转运蛋白和MFS基因介导的流出泵型多重耐药机制 Dipika Shaw and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf434, https://doi.org/10.1093/jac/dkaf434 45 Sphingobacterium spp. as intrinsic producers of SPI Ambler class B metallo-β-lactamases 鞘氨醇杆菌属作为SPI Ambler B类金属β-内酰胺酶的固有产生者 Delphine Girlich and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf436, https://doi.org/10.1093/jac/dkaf436 46 Global phylogeography and genomic characterization of blaNDM-1-positive carbapenem-resistant Acinetobacter soli blaNDM-1阳性碳青霉烯耐药溶胶阿卡净菌的全球系统发育地理学及基因组特征 Pengpeng Min and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf437, https://doi.org/10.1093/jac/dkaf437 47 Pharmacokinetics and tolerability of one-month daily rifapentine for latent tuberculosis treatment in haemodialysis patients 血液透析患者潜伏性结核治疗中每月一次每日利福喷丁的药代动力学及耐受性 Thornthun Ueaphongsukkit and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf439, https://doi.org/10.1093/jac/dkaf439 48 In vitro susceptibility of cefepime-enmetazobactam, cefepime-taniborbactam and cefepime-zidebactam towards carbapenemase-producing Enterobacterales 头孢吡肟-恩美他唑巴坦、头孢吡肟-他尼硼巴坦及头孢吡肟-齐德巴坦对产碳青霉烯酶肠杆菌目的体外敏感性 Marion Dutkiewicz and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf440, https://doi.org/10.1093/jac/dkaf440 49 In vitro efficacy of sulbactam/durlobactam combined with β-lactam antibiotics in Australian Mycobacterium abscessus isolates 舒巴坦/杜洛巴坦联合β-内酰胺类抗生素对澳大利亚脓肿分枝杆菌分离株的体外疗效 Kirby Patterson-Fahy and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf441, https://doi.org/10.1093/jac/dkaf441 50 Harnessing CRISPR–Cas9 and CRISPRi systems to reverse antibiotic resistance in a clinical multidrug-resistant Escherichia coli isolate 利用CRISPR-Cas9及CRISPRi系统逆转临床多重耐药大肠杆菌分离株的抗生素耐药性 Ruonan Zhao and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf442, https://doi.org/10.1093/jac/dkaf442 51 Cotrimoxazole in the intensive care unit: an impossible task for the fixed association in real life? 重症监护室中复方磺胺甲噁唑的应用：固定组合在现实中的不可行性？ Manon Launay and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf443, https://doi.org/10.1093/jac/dkaf443 52 National representative survey of pretreatment HIV drug resistance in Colombia: analysis of antiretroviral resistance-associated mutations using next-generation sequencing 哥伦比亚全国代表性调查：基于下一代测序的抗逆转录病毒耐药相关突变分析 Ernesto Martínez-Buitrago and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf444, https://doi.org/10.1093/jac/dkaf444 53 A model-based comparison of dose reduction strategies for fixed-dose dolutegravir-containing regimens 基于模型的含固定剂量多替拉韦方案减量策略比较 Laura Dickinson and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf445, https://doi.org/10.1093/jac/dkaf445 54 Therapeutic drug monitoring and target attainment of unbound flucloxacillin in hospitalized patients with measured MICs (FLUTE) 住院患者中游离氟氯西林的治疗药物监测及目标达成情况（基于实测最低抑菌浓度的FLUTE研究） Pjotr P Temme and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf447, https://doi.org/10.1093/jac/dkaf447 55 Nirmatrelvir-ritonavir addition to acute care formulary: a retrospective, multi-centre evaluation of quantitative economic and qualitative clinical outcomes 奈玛特韦/利托那韦纳入急症治疗目录：一项多中心回顾性评估定量经济与定性临床结果的研究 Jose Valdes Ledesma and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf448, https://doi.org/10.1093/jac/dkaf448 56 Local antibiotic resistance surveillance in nursing homes using lot quality assurance sampling: a feasibility study 采用批量质量保证抽样法对养老院进行本地抗生素耐药性监测的可行性研究 Sacha Kuil and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf451, https://doi.org/10.1093/jac/dkaf451 57 High in vitro activity of the novel antimicrobial gepotidacin against Neisseria gonorrhoeae isolates in eight WHO Enhanced Gonococcal Antimicrobial Surveillance Programme countries in three WHO regions, 2021–24 2021-2024年，在世卫组织三个区域的八个世卫组织增强淋球菌抗菌药物监测计划国家中，新型抗菌药物吉皮达星对淋病奈瑟菌分离株的体外活性较高 Josefine Ahlstrand and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf452, https://doi.org/10.1093/jac/dkaf452 58 Despite increasing use of integrase inhibitors to treat HIV infection, resistance to this class remains stable 尽管整合酶抑制剂用于治疗HIV感染的使用量不断增加，但此类药物的耐药性仍保持稳定 Cathia Soulie and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf454, https://doi.org/10.1093/jac/dkaf454 59 Fine-needle aspiration in infected necrotizing pancreatitis in the delayed intervention era: a post hoc analysis of safety, microbiological yield and therapeutic implications 延迟干预时代感染性坏死性胰腺炎的细针穿刺抽吸术：安全性、微生物学检出率及治疗意义的事后分析 Hannah S Pauw and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf455, https://doi.org/10.1093/jac/dkaf455 60 β-Lactam dosing in critically ill children: predictors for target non-attainment 危重症儿童β-内酰胺类药物给药：未达目标浓度的预测因素 Stef Schouwenburg and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf457, https://doi.org/10.1093/jac/dkaf457 61 Co-administration of triazoles with calcineurin or mammalian target of rapamycin inhibitors in solid organ transplant patients hospitalized with invasive aspergillosis 实体器官移植患者合并侵袭性曲霉病住院时三唑类药物与钙调磷酸酶抑制剂或哺乳动物雷帕霉素靶蛋白抑制剂的联合用药情况 Barbara Alexander and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf461, https://doi.org/10.1093/jac/dkaf461 62 In vitro selection of cefiderocol-resistant mutants in Acinetobacter baumannii harbouring the most common carbapenemase genes 携带最常见碳青霉烯酶基因的鲍曼不动杆菌中头孢地尔耐药突变体的体外筛选 Otávio Hallal Ferreira Raro and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf462, https://doi.org/10.1093/jac/dkaf462 63 Preventing resistance development in infections by OXA β-lactamase-producing Pseudomonas aeruginosa: correlating clinical outcomes with hollow-fibre model input 预防产OXA β-内酰胺酶铜绿假单胞菌感染耐药性的产生：将临床结局与中空纤维模型输入相关联 María M Montero and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf464, https://doi.org/10.1093/jac/dkaf464 64 A national pilot community pharmacy–led urinary tract infection service: clinical and patient-reported outcomes from 9077 consultations 全国社区药房主导的尿路感染服务试点项目：9077次咨询的临床结局和患者报告结局 Efi Mantzourani and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf466, https://doi.org/10.1093/jac/dkaf466 65 Towards enhanced translational value: preclinical drug activity testing against actively multiplying, nutrient-starved and pellicle biofilm-embedded Mycobacterium abscessus 提高转化价值：针对活跃增殖、营养匮乏和生物膜包裹的脓肿分枝杆菌进行临床前药物活性测试 Henriëtte M Meliefste and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf468, https://doi.org/10.1093/jac/dkaf468 Research Letters（研究快报） 66 Novel multiresistance transposon Tn7731 in bovine Pasteurella multocida from Germany 德国牛源多杀性巴氏杆菌中新型多重耐药转座子Tn7731 Henrike Krüger-Haker and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf336, https://doi.org/10.1093/jac/dkaf336 67 Efficacy of eravacycline in difficult-to-treat (DTR) Acinetobacter baumannii bacteraemia in ICU: a case report 厄他培南治疗重症监护病房难治性鲍曼不动杆菌菌血症的疗效：一例病例报告 Monica Melchio and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf347, https://doi.org/10.1093/jac/dkaf347 68 Possible increased risk of Epstein–Barr virus (EBV) infection and post-transplant lymphoproliferative disease (PTLD) in letermovir-exposed haematopoietic cell transplantation recipients 来特莫韦暴露的造血细胞移植受者中EB病毒感染和移植后淋巴增殖性疾病风险可能增加 Jose F Camargo and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf348, https://doi.org/10.1093/jac/dkaf348 69 Dalbavancin dosing in a severely underweight woman with prosthetic valve endocarditis: the critical role of proactive therapeutic drug monitoring 达巴万星在严重体重不足人工瓣膜心内膜炎女性患者中的给药：主动治疗药物监测的关键作用 Ambra Barco and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf365, https://doi.org/10.1093/jac/dkaf365 70 Cefazolin-induced seizures in a haemodialysis patient with elevated serum and cerebrospinal fluid concentrations: a case report 血液透析患者头孢唑林血清和脑脊液浓度升高诱发癫痫：一例病例报告 Kohei Hasegawa and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf373, https://doi.org/10.1093/jac/dkaf373 71 Retrospective analysis of pharmacological therapeutic monitoring of caspofungin in patients undergoing continuous renal replacement therapy using polyacrylonitrile membranes 使用聚丙烯腈膜进行连续性肾脏替代治疗的患者中卡泊芬净药代动力学治疗监测的回顾性分析 Antoine Hérault and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf390, https://doi.org/10.1093/jac/dkaf390 72 Diffusion of OXA-48- and NDM-5-producing Klebsiella pneumoniae ST383 clone in Central Italy 产OXA-48和NDM-5的肺炎克雷伯菌ST383克隆在意大利中部的传播 Gloria D’Achille and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf397, https://doi.org/10.1093/jac/dkaf397 73 Durability of lenacapavir in viremic heavily treatment-experienced people with HIV: real-world data from the PRESTIGIO Registry 来那卡帕韦在病毒载量阳性且接受过大量抗逆转录病毒治疗的HIV感染者中的持久性：来自PRESTIGIO登记处的现实数据 Tommaso Clemente and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf415, https://doi.org/10.1093/jac/dkaf415 74 Co-carriage of the oxazolidinone resistance genes cfr and optrA in a linezolid-resistant Staphylococcus rostri isolate from a pig-farm worker 猪场工人利奈唑胺耐药猪鼻支原体分离株中噁唑烷酮类耐药基因cfr和optrA的共携带情况 Gi Yong Lee and Soo-Jin Yang Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf428, https://doi.org/10.1093/jac/dkaf428 75 Importance of reviewing the package insert from gradient strip manufacturers 梯度扩散法药敏纸片生产商说明书审阅的重要性 Mandy Wootton and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf429, https://doi.org/10.1093/jac/dkaf429 76 One resistance gene, many transposons: repeated formation of compound and pseudo-compound transposons carrying the aphA1 kanamycin and neomycin resistance gene 一个耐药基因，多个转座子：携带aphA1卡那霉素和新霉素耐药基因的复合及假复合转座子的重复形成 Christopher J Harmer and Ruth M Hall Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf450, https://doi.org/10.1093/jac/dkaf450 77 Absence of lymphogranuloma venereum among men who have sex with men on PrEP receiving doxycycline postexposure prophylaxis 接受暴露后多西环素预防性治疗的暴露前预防用药男男性行为者中未发现性病淋巴肉芽肿 Cristina Gómez-Ayerbe and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf456, https://doi.org/10.1093/jac/dkaf456 78 In vitro activity of gepotidacin against Chlamydia trachomatis 吉皮达星对沙眼衣原体的体外活性 Arabella Touati and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 1, January 2026, dkaf460, https://doi.org/10.1093/jac/dkaf460 Journal of Antimicrobial Chemotherapy Volume 81, Issue 2抗菌化疗杂志 81卷 2期 https://academic.oup.com/jac/issue Viewpoints（观点） 1 Long-acting glycopeptides: what are the barriers to access in patients who need them most, and how can they be overcome? 长效糖肽类：最需要它们的患者获取药物的障碍有哪些，如何克服？ Aleece MacPhail and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 2, February 2026, dkaf471, https://doi.org/10.1093/jac/dkaf471 2 Redefining antifungal prophylaxis in acute leukaemia in the era of targeted therapies 靶向治疗时代急性白血病抗真菌预防的重新定义 Marcio Nucci and Johan Maertens Journal of Antimicrobial Chemotherapy, Volume 81, Issue 2, February 2026, dkag010, https://doi.org/10.1093/jac/dkag010 Reviews（综述） 3 Research progress on resistance mechanisms and clinical efficacy of tigecycline against Klebsiella pneumoniae 替加环素对肺炎克雷伯菌的耐药机制及临床疗效研究进展 Meilin Wu and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 2, February 2026, dkaf504, https://doi.org/10.1093/jac/dkaf504 4 Liposomal amphotericin B and renal safety: review of the evidence and clinical considerations 两性霉素B脂质体与肾脏安全性：证据回顾及临床考量 Johan Maertens and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 2, February 2026, dkaf473, https://doi.org/10.1093/jac/dkaf473 5 Strategies for mitigating severe COVID-19 in patients with haematological malignancy during the omicron era 奥密克戎时代减轻血液系统恶性肿瘤患者严重新冠肺炎的策略 Keiji Okinaka and Joshua T Schiffer Journal of Antimicrobial Chemotherapy, Volume 81, Issue 2, February 2026, dkaf489, https://doi.org/10.1093/jac/dkaf489 Systematic Reviews（系统综述） 6 Safety and efficacy of gepotidacin in urinary tract infection: a GRADE-assessed systematic review and meta-analysis 吉泊替达辛治疗尿路感染的安全性和有效性：一项基于GRADE评估的系统综述和荟萃分析 Taha Ibrahim and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 2, February 2026, dkaf469, https://doi.org/10.1093/jac/dkaf469 7 The emerging clinical relevance and antimicrobial resistance of Pluralibacter gergoviae: a systematic review 产吲哚金黄杆菌日益凸显的临床相关性和抗菌药物耐药性：一项系统综述 Bruna Abdul Ahad Saad and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 2, February 2026, dkaf476, https://doi.org/10.1093/jac/dkaf476 8 A comprehensive analysis of the mutational landscape determining polymyxin resistance in Klebsiella pneumoniae 决定肺炎克雷伯菌多粘菌素耐药性的突变谱综合分析 Sambit Kumar Dwibedy and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 2, February 2026, dkaf503, https://doi.org/10.1093/jac/dkaf503 9 Factors promoting or hindering self-administered outpatient parenteral antimicrobial therapy: a systematic literature review 促进或阻碍自我给药门诊静脉注射抗菌药物治疗的因素：一项系统文献综述 Hester H Stoorvogel and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 2, February 2026, dkaf490, https://doi.org/10.1093/jac/dkaf490 Original Research（论著） 10 Cefepime/enmetazobactam for Gram-negative periprosthetic joint infections? A randomized porcine study on target tissue pharmacokinetics 头孢吡肟/恩美唑巴坦治疗革兰氏阴性假体周围关节感染？一项关于猪的靶组织药代动力学的随机研究 M B D Nielsen and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 2, February 2026, dkaf487, https://doi.org/10.1093/jac/dkaf487 11 Impact of extracorporeal membrane oxygenation modes on voriconazole exposure in critically ill patients 体外膜肺氧合模式对危重患者伏立康唑暴露的影响 Xinrui Wang and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 2, February 2026, dkaf501, https://doi.org/10.1093/jac/dkaf501 12 Model-based assessment of VRC07-523LS dosing in infants through population pharmacokinetic -pharmacodynamic modelling in adults and infants 基于模型通过成人和婴儿群体药代动力学-药效学模型评估VRC07-523LS在婴儿中的给药方案 Dustin Huynh and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 2, February 2026, dkaf449, https://doi.org/10.1093/jac/dkaf449 13 Antibiotic resistance of Pseudomonas aeruginosa strains—intracellular metabolomics analysis 铜绿假单胞菌菌株的抗生素耐药性——细胞内代谢组学分析 Karolina Anna Mielko-Niziałek and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 2, February 2026, dkaf453, https://doi.org/10.1093/jac/dkaf453 14 In vitro activity of cefepime/zidebactam against sulbactam/durlobactam-susceptible and -resistant Acinetobacter baumannii clinical isolates 头孢吡肟/齐多巴坦对舒巴坦/杜洛巴坦敏感和耐药鲍曼不动杆菌临床分离株的体外活性 Carlo Tascini and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 2, February 2026, dkaf467, https://doi.org/10.1093/jac/dkaf467 15 Prevalence of macrolide resistance in Mycoplasma pneumoniae in The Netherlands 荷兰肺炎支原体大环内酯类抗生素耐药性的流行情况 Patrick D J Sturm and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 2, February 2026, dkaf475, https://doi.org/10.1093/jac/dkaf475 16 Simulated lung exposure in pneumonia patients to evaluate the antibacterial capacity and resistance suppression of clinical tigecycline regimens against carbapenem-resistant Acinetobacter baumannii 模拟肺炎患者肺部暴露情况以评估临床替加环素方案对碳青霉烯类耐药鲍曼不动杆菌的抗菌能力和耐药抑制作用 Xiaonan Zhang and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 2, February 2026, dkaf477, https://doi.org/10.1093/jac/dkaf477 17 Enterococcus faecium harbouring vanA, optrA and cfr(D) on a linear plasmid in Canada: a CANWARD surveillance case 加拿大发现携带vanA、optrA和cfr(D)的粪肠球菌线性质粒：一项CANWARD监测病例 Melissa McCracken and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 2, February 2026, dkaf478, https://doi.org/10.1093/jac/dkaf478 18 The effect of intrauterine exposure to aminoglycosides on neonatal hearing 宫内暴露于氨基糖苷类抗生素对新生儿听力的影响 Daniel Leshin-Carmel and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 2, February 2026, dkaf483, https://doi.org/10.1093/jac/dkaf483 19 Ceftazidime/avibactam: a potent arsenal against multidrug-resistant Pseudomonas aeruginosa-unveiling in vitro and in vivo strategies 头孢他啶/阿维巴坦：对抗多重耐药铜绿假单胞菌的有力武器——揭示体内外策略 Jiaju Zhuo and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 2, February 2026, dkaf495, https://doi.org/10.1093/jac/dkaf495 20 Comparison of disk diffusion, MIC test strip and broth microdilution for eravacycline susceptibility testing of 422 Staphylococcus aureus isolates using ChinaCAST breakpoints 采用中国CAST折点，比较422株金黄色葡萄球菌对依拉环素的纸片扩散法、最低抑菌浓度测试条法和肉汤微量稀释法的敏感性测试结果 Xinying Wang and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 2, February 2026, dkaf502, https://doi.org/10.1093/jac/dkaf502 21 Penetration of daptomycin in cerebrospinal fluid during pneumococcal meningitis 肺炎链球菌性脑膜炎期间达托霉素在脑脊液中的渗透情况 Pascal Chavanet and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 2, February 2026, dkaf474, https://doi.org/10.1093/jac/dkaf474 22 Rapid molecular diagnostics for detection of extensively drug-resistant Salmonella Typhi 用于检测广泛耐药伤寒沙门菌的快速分子诊断技术 Emma L Sweeney and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 2, February 2026, dkaf481, https://doi.org/10.1093/jac/dkaf481 23 Gender inequality and antibiotic consumption: analysis of pharmaceutical sales data from 70 countries, 2000–22 性别不平等与抗生素消费：基于2000 - 2022年70个国家药品销售数据的分析 Deepshikha Batheja and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 2, February 2026, dkag002, https://doi.org/10.1093/jac/dkag002 24 Real-world evaluation of isavuconazole in children with cancer 伊沙康唑在儿童癌症患者中的现实应用评估 Janine Nijhuis and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 2, February 2026, dkaf485, https://doi.org/10.1093/jac/dkaf485 25 Assessing antimicrobial susceptibility testing guideline adherence by laboratories providing bacteriology services in Ghana: a pilot study 加纳提供细菌学服务的实验室对抗菌药物敏感性试验指南依从性的评估：一项试点研究 Joseph Elikem Efui Acolatse and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 2, February 2026, dkag003, https://doi.org/10.1093/jac/dkag003 26 Resistance to second-generation integrase inhibitors in people with HIV following treatment failure on dolutegravir- or bictegravir-based ART in Taiwan 台湾地区基于多替拉韦或比克替拉韦的抗逆转录病毒治疗失败后，HIV感染者对第二代整合酶抑制剂的耐药性 Guan-Jhou Chen and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 2, February 2026, dkaf488, https://doi.org/10.1093/jac/dkaf488 27 In vitro activity of gepotidacin against a challenging panel of multidrug-resistant Neisseria gonorrhoeae isolates 吉泊西汀对一组具有挑战性的多重耐药淋病奈瑟菌分离株的体外活性 Michelle Jayne Cole and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 2, February 2026, dkag001, https://doi.org/10.1093/jac/dkag001 28 A disproportionality analysis of adverse events associated with omadacycline based on the FDA adverse event reporting system database 基于美国食品药品监督管理局（FDA）不良事件报告系统数据库的奥马环素相关不良事件比例失衡分析 Ye-Lei Zhao and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 2, February 2026, dkag006, https://doi.org/10.1093/jac/dkag006 29 Weight-band-based simplification of oral allometric miltefosine dosing in paediatric patients with visceral leishmaniasis 基于体重范围的口服异速缩放米替福新给药方案在儿童内脏利什曼病患者中的简化应用 Andres Mazariegos Herrera and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 2, February 2026, dkag014, https://doi.org/10.1093/jac/dkag014 30 evelopment of a capability framework for antimicrobial stewardship specialist health professionals working in the NHS in England: utilizing Delphi methodology 运用德尔菲法为在英国国家医疗服务体系（NHS）中工作的抗菌药物管理专业人员制定能力框架 Ryan A Hamilton and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 2, February 2026, dkaf438, https://doi.org/10.1093/jac/dkaf438 31 First characterization of insertions in the HIV-1 integrase-coding region from people with HIV 首次对来自艾滋病病毒感染者的HIV-1整合酶编码区插入情况进行特征分析 Nhat Quang Tu and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 2, February 2026, dkaf491, https://doi.org/10.1093/jac/dkaf491 32 Development of an impedance-based fast antimicrobial susceptibility test for Neisseria gonorrhoeae 开发一种基于阻抗的淋病奈瑟菌快速抗菌药物敏感性检测方法 Caitlin N Daniels and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 2, February 2026, dkaf493, https://doi.org/10.1093/jac/dkaf493 33 Juvenile toxicity and developmental safety of Zintrodiazine, a novel antimalarial candidate, in Wistar rats 新型抗疟候选药物Zintrodiazine在Wistar大鼠中的幼年毒性和发育安全性研究 Hitesh A Kadu and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 2, February 2026, dkag008, https://doi.org/10.1093/jac/dkag008 34 Do the redefined EUCAST susceptibility categories warrant adjustment of paediatric antibiotic dosages? Pragmatic physiologically based pharmacokinetic modelling of four commonly used agents 欧洲抗微生物药物敏感性试验委员会（EUCAST）重新定义的敏感性分类是否需要调整儿童抗生素剂量？——对四种常用药物的实用生理药代动力学建模研究 Marika A de Hoop-Sommen and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 2, February 2026, dkaf463, https://doi.org/10.1093/jac/dkaf463 35 Exploring the opportunity for therapeutic drug monitoring (TDM) and precision dose antimicrobials in an outpatient antimicrobial therapy (OPAT) service: a prospective observational study 门诊抗菌治疗（OPAT）服务中开展治疗药物监测（TDM）和精准剂量抗菌治疗的机遇：一项前瞻性观察研究 R C Wilson and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 2, February 2026, dkaf484, https://doi.org/10.1093/jac/dkaf484 36 Impact of sex, age and body composition on rilpivirine and cabotegravir trough concentrations in people with HIV receiving long-acting injectable antiretroviral therapy 性别、年龄和身体成分对接受长效注射用抗逆转录病毒治疗的HIV感染者利匹韦林和卡博特韦谷浓度的影响 Maria Vittoria Cossu and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 2, February 2026, dkag024, https://doi.org/10.1093/jac/dkag024 37 Pharmacokinetics of cefiderocol during prolonged intermittent kidney replacement therapy in two patients with septic shock 头孢地尔在两例感染性休克患者长时间间歇性肾脏替代治疗期间的药代动力学 Julius J Schmidt and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 2, February 2026, dkaf496, https://doi.org/10.1093/jac/dkaf496 38 Understanding mechanisms of reduced cefiderocol susceptibility in pvdS and fecI mutants of Pseudomonas aeruginosa 了解铜绿假单胞菌pvdS和fecI突变体对头孢地尔敏感性降低的机制 Yoshinori Yamano and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 2, February 2026, dkag004, https://doi.org/10.1093/jac/dkag004 39 Biomarker-informed PBPK modelling of meropenem in paediatric severe pneumonia: implications for target-site PK/PD 基于生物标志物的美罗培南在儿童重症肺炎中的生理药动学模型构建：对靶部位药代动力学/药效学的影响 Yao Liu and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 2, February 2026, dkaf500, https://doi.org/10.1093/jac/dkaf500 40 Evaluating hypoalbuminaemia thresholds associated with delayed blood sterilization among patients receiving cefazolin or antistaphylococcal penicillins for MSSA bacteraemia 评估接受头孢唑林或抗葡萄球菌青霉素治疗甲氧西林敏感金黄色葡萄球菌（MSSA）菌血症患者中，与血液延迟灭菌相关的低白蛋白血症阈值 Sunish Shah and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 2, February 2026, dkaf498, https://doi.org/10.1093/jac/dkaf498 Research Letters（研究快讯） 41 False-negative result in fourth-generation HIV screening tests after weak detection of p24 antigen in the context of inappropriate post-exposure prophylaxis use: a case report 不当使用暴露后预防用药导致第四代HIV筛查试验p24抗原弱检出后出现假阴性结果：一例病例报告 J Kimmerlin and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 2, February 2026, dkaf459, https://doi.org/10.1093/jac/dkaf459 42 Proposal for the nomenclature of tmexCD-toprJ-like gene clusters 关于tmexCD-toprJ样基因簇命名的建议 Chengzhen Wang and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 2, February 2026, dkaf482, https://doi.org/10.1093/jac/dkaf482 43 IS26-mediated chromosomal integration of virulence plasmid fragments in ST2237 carbapenem-resistant Klebsiella pneumoniae IS26介导的毒力质粒片段在ST2237型碳青霉烯耐药肺炎克雷伯菌染色体中的整合 Yan Li and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 2, February 2026, dkag018, https://doi.org/10.1093/jac/dkag018 Letter to the Editor（致编辑的信） 44 Comment on: Retrospective analysis of pharmacological therapeutic monitoring of caspofungin in patients undergoing continuous renal replacement therapy using polyacrylonitrile membranes 对“采用聚丙烯腈膜对接受连续性肾脏替代治疗的患者进行卡泊芬净药代动力学监测的回顾性分析”的评论 Gwénola Marais and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 2, February 2026, dkaf465, https://doi.org/10.1093/jac/dkaf465 45 Antimicrobial use for the treatment of bacterial sexually transmitted infections among doxycycline post-exposure prophylaxis (DoxyPEP) users in Milan, Italy-right-to-reply 意大利米兰地区使用多西环素暴露后预防（DoxyPEP）人群中，用于治疗细菌性传播感染的抗菌药物使用情况——回应说明 Angelo Roberto Raccagni and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 2, February 2026, dkag027, https://doi.org/10.1093/jac/dkag027 ACKNOWLEDGEMENT OF REFEREES（鸣谢审稿专家） 46 Acknowledgement of Referees 鸣谢审稿专家 Journal of Antimicrobial Chemotherapy, Volume 81, Issue 2, February 2026, dkaf417, https://doi.org/10.1093/jac/dkaf417 CORRECTION（更正） 47 Correction to: Comment on: Antiviral effect of Evusheld in COVID-19 hospitalized patients infected with pre-Omicron or Omicron variants: a modelling analysis of the randomized DisCoVeRy trial 更正：关于Evusheld在感染奥密克戎变异株前或奥密克戎变异株的新冠住院患者中的抗病毒效果：对随机DisCoVeRy试验的建模分析的评论 Journal of Antimicrobial Chemotherapy, Volume 81, Issue 2, February 2026, dkaf492, https://doi.org/10.1093/jac/dkaf492 Journal of Antimicrobial Chemotherapy Volume 81, Issue 3抗菌化疗杂志 81卷 3期 https://academic.oup.com/jac/issue REVIEW（综述） 1 Closing the PrEP access gap in Europe: a strategic framework for equity and innovation among difficult-to-reach populations 缩小欧洲暴露前预防获取差距：面向难以触及（PrEP）人群的公平与创新战略框架 Josep M Llibre and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag052, https://doi.org/10.1093/jac/dkag052 2 Precision dosing of systemic antifungals in adults: therapeutic drug monitoring, empiric dose optimization and barriers to implementation 成人全身性抗真菌药物的精准给药：治疗药物监测、经验性剂量优化及实施障碍 Daniel B Chastain and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag055, https://doi.org/10.1093/jac/dkag055 3 Bacterial DNA topoisomerase IV and DNA gyrase inhibitors: history of the quinolones, their clinical usage and potential alternatives for the future 细菌DNA拓扑异构酶IV和DNA旋转酶抑制剂：喹诺酮类药物的历史、临床应用及未来潜在替代方案 Daisuke Fukuda and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag054, https://doi.org/10.1093/jac/dkag054 4 Combating multidrug-resistant Klebsiella pneumoniae: current therapeutic regimens and future directions 应对多重耐药肺炎克雷伯菌：当前治疗方案与未来方向 Robiul Islam and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag064, https://doi.org/10.1093/jac/dkag064 SYSTEMATIC REVIEW（系统综述） 5 Global and regional prevalence of metallo-β-lactamases in carbapenem-resistant Acinetobacter baumannii: a systematic review and meta-analysis 耐碳青霉烯类鲍曼不动杆菌中金属β-内酰胺酶的全球和区域流行情况：一项系统综述和荟萃分析 Stamatis Karakonstantis and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag037, https://doi.org/10.1093/jac/dkag037 Original Research（论著） 6 The effect of oral ciprofloxacin at conventional doses on the QT interval in a tertiary outpatient setting 三级门诊常规剂量口服环丙沙星对患者QT间期的影响 Weber Liu and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag020, https://doi.org/10.1093/jac/dkag020 7 Bictegravir concentrations in breastmilk of healthy, lactating women without HIV 未感染人类免疫缺陷病毒（HIV）的健康哺乳期女性乳汁中的比克替拉韦浓度 L C van der Wekken-Pas and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag022, https://doi.org/10.1093/jac/dkag022 8 Management and outcomes of Stenotrophomonas maltophilia recovered from deep-site clinical specimens: a bicentric retrospective cohort study 从深部部位临床标本中分离出的嗜麦芽窄食单胞菌的治疗及转归：一项双中心回顾性队列研究 Anastasia Saade and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag021, https://doi.org/10.1093/jac/dkag021 9 Development of a risk prediction model for vancomycin-associated acute kidney injury: a multicentre retrospective study 万古霉素相关急性肾损伤风险预测模型的建立：一项多中心回顾性研究 Tomoyuki Ishigo and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag012, https://doi.org/10.1093/jac/dkag012 10 Cooperation between HIV-1 integrase natural polymorphism K156N and 3′PPT mutations in dolutegravir monotherapy failure HIV-1 整合酶天然多态性 K156N 与 3′PPT 突变在多替拉韦单药治疗失败中的协同作用 Jolieke A T van Osch and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag033, https://doi.org/10.1093/jac/dkag033 11 Impact of body mass index and serum albumin levels on isavuconazole plasma concentrations in patients with haematological malignancies 体重指数和血清白蛋白水平对血液系统恶性肿瘤患者艾沙康唑血浆浓度的影响 Jie Gao and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag032, https://doi.org/10.1093/jac/dkag032 12 Pharmacokinetics of cefotaxime and its metabolite desacetyl-cefotaxime to optimize dosing in critically ill children and children with sickle cell disease 用以优化危重症儿童和镰状细胞病儿童给药剂量的头孢噻肟及其代谢产物去乙酰头孢噻肟的药代动力学研究 Seef Abdalla and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag019, https://doi.org/10.1093/jac/dkag019 13 Summary of ceftriaxone-resistant Neisseria gonorrhoeae in Canada, 2017–24 2017 - 2024年加拿大头孢曲松耐药淋病奈瑟菌情况汇总 Robyn Thorington and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag007, https://doi.org/10.1093/jac/dkag007 14 Improving perioperative prophylactic antibiotic prescribing using a novel decision-support tool 使用新型决策支持工具改进围手术期预防性抗生素处方 Mark Mcintyre and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag015, https://doi.org/10.1093/jac/dkag015 15 Comparative activity of established versus new-generation β-lactams against AmpC-hyperproducing clinical isolates of Enterobacter cloacae complex and Klebsiella aerogenes: a multicentre study 针对产超广谱AmpC酶的阴沟肠杆菌复合群和产气克雷伯菌临床分离株，比较已上市与新一代β-内酰胺类抗生素的抗菌活性：一项多中心研究 Ángel Rodríguez-Villodres and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag034, https://doi.org/10.1093/jac/dkag034 16 Impact of eravacycline on fibrinogen 依拉环素对纤维蛋白原的影响 Emily Stevenson and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag030, https://doi.org/10.1093/jac/dkag030 17 Biliary pharmacokinetic/pharmacodynamic analysis of continuous infusion ceftazidime–avibactam in a case series of orthotopic liver transplant recipients 原位肝移植受者连续输注头孢他啶-阿维巴坦的药代动力学/药效学胆系分析：一项病例系列研究 Milo Gatti and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag009, https://doi.org/10.1093/jac/dkag009 18 Autoaggregation-associated carbapenem tolerance mediated by mrkH inactivation identified from a cohort of Klebsiella pneumoniae species complex clinical isolates 从肺炎克雷伯菌复合群临床分离株队列中鉴定出由mrkH失活介导的与自动聚集相关的碳青霉烯耐受性 Natsuki Yamanaka and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag017, https://doi.org/10.1093/jac/dkag017 19 In vitro activity of double and triple antimicrobial combinations against carbapenem-resistant Pseudomonas aeruginosa biofilm 双联和三联抗菌药物组合对碳青霉烯耐药铜绿假单胞菌生物膜的体外活性研究 Si-Ho Kim and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag031, https://doi.org/10.1093/jac/dkag031 20 LYSC98 as a novel vancomycin-derived agent effective against antibiotic-resistant pathogens in tolerant state LYSC98作为一种新型万古霉素衍生物，对耐受状态下的耐药病原体有效 Xing Xia and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag036, https://doi.org/10.1093/jac/dkag036 21 HBV status modulates transaminase decrease after switching from tenofovir disoproxil fumarate to tenofovir alafenamide in people with HIV HIV感染者从富马酸替诺福韦二吡呋酯切换为丙酚替诺福韦后，HBV状态对转氨酶下降的调节作用 Giuseppe Lapadula and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag045, https://doi.org/10.1093/jac/dkag045 22 Pharmacokinetics of colistin in adult critically ill patients in South Africa 南非成人危重症患者中多黏菌素的药代动力学研究 Veshni Pillay-Fuentes Lorente and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag011, https://doi.org/10.1093/jac/dkag011 23 Antifungal susceptibility surveillance of clinical moulds to olorofim, manogepix, amphotericin B, triazoles and echinocandins at 10 tertiary hospitals in China (2019–24) 2019 - 2024年中国10家三级医院临床霉菌对奥罗芬净、马诺盖匹克斯、两性霉素B、三唑类和棘白菌素类抗真菌药的敏感性监测 Su Chen and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag016, https://doi.org/10.1093/jac/dkag016 24 Short-cycle three-day-per-week efavirenz/emtricitabine/tenofovir disoproxil fumarate therapy: a seven-year extension study 短周期每周三日依非韦伦/恩曲他滨/富马酸替诺福韦二吡呋酯疗法：一项为期七年的延长研究 Beatriz Borjabad and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag040, https://doi.org/10.1093/jac/dkag040 25 Risk of hypertension in people with HIV in the USA initiating modern antiretroviral regimens: pooled analysis of blood pressure data from five clinical trials 美国感染HIV者启动现代抗逆转录病毒治疗方案后患高血压的风险：五项临床试验血压数据汇总分析 Priscilla Y Hsue and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag005, https://doi.org/10.1093/jac/dkag005 26 Real-world drug monitoring of dalbavancin using a three-dose regimen of 1500mg at days 1, 15 and 43 in bone and joint or cardiovascular infection 采用第1、15和43天各1500毫克的三剂量方案对达巴万星（Dalbavancin）在骨关节或心血管感染治疗中的实际药物监测研究 Thomas Lin and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag039, https://doi.org/10.1093/jac/dkag039 27 Nationwide patterns of HIV drug resistance and high viral load in Sub-Saharan African countries 撒哈拉以南非洲国家全国范围内的HIV耐药及高病毒载量模式 Abubaker Ibrahim Elbur and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkaf497, https://doi.org/10.1093/jac/dkaf497 28 Risk factors for suboptimal target attainment of commonly used ß-lactam antibiotics in older adults: a prospective cohort study 老年人常用β-内酰胺类抗生素未达最佳治疗目标的风险因素：一项前瞻性队列研究 Arnaud De Clercq and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag048, https://doi.org/10.1093/jac/dkag048 29 Physiologically based pharmacokinetic modelling to optimize dosing regimen of biapenem in renal impairment and elderly populations 基于生理的药代动力学模型优化肾功能不全及老年人群比阿培南给药方案 Wenyan Li and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkaf499, https://doi.org/10.1093/jac/dkaf499 30 Early targeted therapy guided by rapid phenotypic antimicrobial susceptibility testing in critically ill patients with Gram-negative bacterial bloodstream infections: a retrospective cohort study 快速表型抗菌药物敏感性试验指导下的早期目标性治疗对革兰氏阴性菌血流感染危重患者的效果：一项回顾性队列研究 Salvatore Rotundo and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag056, https://doi.org/10.1093/jac/dkag056 31 Impact of COVID-19-related healthcare changes on antibiotic resistance in clinical Escherichia coli isolates: interrupted time series analyses in Scotland, UK 与新冠肺炎相关的医疗变化对英国苏格兰地区临床大肠杆菌分离株抗生素耐药性的影响：中断时间序列分析 Laura Ciaccio and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag049, https://doi.org/10.1093/jac/dkag049 32 Multicentre evaluation of teicoplanin prescribing and monitoring in the UK and Ireland: the TUcK–SHOP study 英国和爱尔兰替考拉宁处方与监测的多中心评估：TUcK–SHOP研究 Stephen Hughes and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag038, https://doi.org/10.1093/jac/dkag038 33 Diabetes and risk of significant fibrosis in adults with HIV and metabolic dysfunction-associated steatotic liver disease: a prospective cohort study 糖尿病与HIV合并代谢功能障碍相关脂肪性肝病成人患者发生显著肝纤维化的风险：一项前瞻性队列研究 Win Min Han and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag053, https://doi.org/10.1093/jac/dkag053 34 A pharmacovigilance analysis of carbapenem-related utilizing the FDA adverse event reporting system (FAERS) database from 2013 to 2025 基于美国食品药品监督管理局不良事件报告系统（FAERS）数据库2013 - 2025年数据的碳青霉烯类相关药物警戒分析 Connor Frey and Parham Elmi Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag060, https://doi.org/10.1093/jac/dkag060 35 Effects of extracorporeal membrane oxygenation on the pharmacokinetics and tissue penetration rates of vancomycin and linezolid: data from Landrace pigs 体外膜肺氧合对万古霉素和利奈唑胺药代动力学及组织穿透率的影响：来自长白猪的数据 Huifang Zhang and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag063, https://doi.org/10.1093/jac/dkag063 36 Switching to bictegravir/emtricitabine/tenofovir alafenamide in people with HIV and prior resistance mutations. Data from the Italian ARCA cohort: the BIC-BARRIER study. B/F/TAF switch: mutations and outcomes 在既往存在耐药突变的人类免疫缺陷病毒（HIV）感染者中换用比克替拉韦/恩曲他滨/丙酚替诺福韦治疗。来自意大利ARCA队列的数据：BIC-BARRIER研究。比克替拉韦/恩曲他滨/丙酚替诺福韦（B/F/TAF）换药方案：耐药突变与治疗结果 Laura Pezzati and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag035, https://doi.org/10.1093/jac/dkag035 37 A two-stage diagnostic model for discriminating and assessing risk of meropenem heteroresistance in Pseudomonas aeruginosa 用于鉴别和评估铜绿假单胞菌对美罗培南异质性耐药风险的二阶段诊断模型 Yali Fan and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag061, https://doi.org/10.1093/jac/dkag061 38 Microdialysis assessment of gentamicin for second-line antimicrobial prophylaxis in abdominal surgery 微透析评估庆大霉素在腹部手术中作为二线抗菌预防药物的效果 Quentin Saint-Genis and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag071, https://doi.org/10.1093/jac/dkag071 39 Genetic and clinical predictors of voriconazole pharmacokinetics and hepatotoxicity: focused on CYP2C19 normal and intermediate metabolizers 伏立康唑药代动力学及肝毒性的遗传和临床预测因素：聚焦于CYP2C19正常代谢型和中间代谢型 Hui Li and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag065, https://doi.org/10.1093/jac/dkag065 40 Stakeholder perspectives on the offer and acceptance of self-administration of outpatient parenteral antimicrobial therapy: a qualitative study 利益相关者对提供和接受门诊患者自行注射抗菌药物治疗的看法：一项定性研究 Hester H Stoorvogel and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag068, https://doi.org/10.1093/jac/dkag068 41 Is current guidance for cloxacillin prophylaxis dosages in hip and knee arthroplasty adequate? Evidence from a prospective Swedish cohort 当前髋关节和膝关节置换术中氯唑西林预防性用药剂量指南是否充分？来自一项前瞻性瑞典队列研究的证据 Katja Wallander and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag067, https://doi.org/10.1093/jac/dkag067 42 Effect of pretreatment HIV drug resistance on mortality, attrition and viral suppression in patients initiating antiretroviral therapy and genetic transmission network: an observational cohort study in Southwest China 治疗前HIV药物耐药性对开始接受抗逆转录病毒治疗患者的死亡率、失访率和病毒抑制率的影响以及遗传传播网络：中国西南地区一项观察性队列研究 Litai Qin and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag073, https://doi.org/10.1093/jac/dkag073 RESEARCH LETTER（研究快讯） 43 Varicella and varicella zoster virus meningoencephalitis in a diffuse large B-cell lymphoma patient after chimeric antigen receptor-T-cell therapy 嵌合抗原受体T细胞疗法后，弥漫性大B细胞淋巴瘤患者发生水痘及水痘-带状疱疹病毒脑膜脑炎 Yan Feng and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag041, https://doi.org/10.1093/jac/dkag041 44 The ‘double hit’ on dalbavancin pharmacokinetics: hypertriglyceridaemia and augmented renal clearance in a child with glycogen storage disease type Ib 糖原累积病Ib型患儿中，高甘油三酯血症和肾清除率增加对达巴万星药代动力学的“双重打击” Bianca Monti and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag028, https://doi.org/10.1093/jac/dkag028 45 Tn7860, a novel chromosomal pseudo-compound transposon carrying the OptrA gene in Enterococcus faecalis Tn7860，粪肠球菌中携带OptrA基因的一种新型染色体假复合转座子 Francesca Romana Massacci and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag046, https://doi.org/10.1093/jac/dkag046 46 HBV reactivation after switching to cabotegravir plus rilpivirine therapy among people living with HIV: do not forget the reservoir HIV感染者换用卡博特韦（cabotegravir）联合利匹韦林（rilpivirine）治疗后乙肝病毒再激活：切勿忽视病毒储存库 Rémi Rouget and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag050, https://doi.org/10.1093/jac/dkag050 47 An inoperable mediastinal infection involving vascular graft treated with weekly oritavancin as chronic suppressive therapy. A case report with pharmacokinetic data 一例涉及血管移植物的无法手术的纵隔感染，采用每周一次的奥利万星作为慢性抑制疗法。附药代动力学数据的病例报告 Pierangelo Chinello and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag013, https://doi.org/10.1093/jac/dkag013 48 Evaluation of the Carbapenemase Detection Kit (Colloidal Gold; Macro & Micro Test): a new immunochromatographic assay for rapid detection of carbapenemases in Enterobacterales 碳青霉烯酶检测试剂盒（胶体金法；宏基因与微基因检测法）评估：一种用于快速检测肠杆菌目细菌中碳青霉烯酶的新型免疫层析法 Hippolyte De Swardt and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag066, https://doi.org/10.1093/jac/dkag066 49 Cefalexin use in UK acute pyelonephritis practice: unaddressed challenges in dosing, breakpoints and clinical evidence 头孢氨苄在英国急性肾盂肾炎治疗中的应用：给药、断点和临床证据方面尚未解决的挑战 Stephen Hughes and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag051, https://doi.org/10.1093/jac/dkag051 LETTERS TO THE EDITOR（致编辑的信） 50 Comment on: Antimicrobial use for the treatment of bacterial sexually transmitted infections among doxycycline post-exposure prophylaxis (DoxyPEP) users in Milan, Italy 评论：意大利米兰多西环素暴露后预防（DoxyPEP）使用者中用于治疗细菌性性传播感染的抗菌药物使用情况 Chris Kenyon Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag025, https://doi.org/10.1093/jac/dkag025 51 Possible increased risk of Epstein–Barr virus (EBV) infection and post-transplant lymphoproliferative disease (PTLD) in letermovir-exposed haematopoietic cell transplantation recipients: right-to-reply 来特莫韦暴露的造血细胞移植受者发生EB病毒（EBV）感染和移植后淋巴增殖性疾病（PTLD）的风险可能增加：答复权 Jose F Camargo and Anthony D Anderson Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag043, https://doi.org/10.1093/jac/dkag043 52 Antimicrobial use for the treatment of bacterial sexually transmitted infections among doxycycline post-exposure prophylaxis (DoxyPEP) users in Milan, Italy—right-to-reply 意大利米兰市使用多西环素暴露后预防（DoxyPEP）人群中，用于治疗细菌性性传播感染的抗菌药物使用情况——答复权声明 Angelo Roberto Raccagni and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag026, https://doi.org/10.1093/jac/dkag026 53 Comment on: Artificial intelligence for improving decision-making in bacterial infection management 述评：人工智能在细菌感染管理决策中的优化作用 Daniele Roberto Giacobbe Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag078, https://doi.org/10.1093/jac/dkag078 CORRECTION（更正） 54 Correction to: Bayesian estimation of the prevalence of antimicrobial resistance: a mathematical modelling study 更正：抗菌药物耐药性流行率的贝叶斯估计：一项数学建模研究 Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkaf494, https://doi.org/10.1093/jac/dkaf494 55 Correction to: National representative survey of pretreatment HIV drug resistance in Colombia: analysis of antiretroviral resistance-associated mutations using next-generation sequencing 更正：哥伦比亚具有全国代表性的治疗前HIV耐药性调查：使用下一代测序技术分析抗逆转录病毒耐药相关突变 Journal of Antimicrobial Chemotherapy, Volume 81, Issue 3, March 2026, dkag057, https://doi.org/10.1093/jac/dkag057 Journal of Antimicrobial Chemotherapy Volume 81, Issue 4抗菌化疗杂志81卷 4期 https://academic.oup.com/jac/issue 50TH ANNIVERSARY COLLECTION（50周年纪念合集） GARROD LECTURE（加罗德讲座） 1 Garrod lecture: achieving the UNGA AMR mortality reduction goals 加罗德讲座：实现联合国大会抗菌药物耐药性死亡率降低目标 Ramanan Laxminarayan Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag082, https://doi.org/10.1093/jac/dkag082 REVIEW（综述） 2 25 years of improvement in mortality in invasive aspergillosis in haematology patients: will it be sustained or is it under threat? 侵袭性曲霉病血液病患者25年死亡率改善情况：这种改善能否持续，还是正受到威胁？ Johan A Maertens and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag077, https://doi.org/10.1093/jac/dkag077 3 A strategic discovery roadmap towards high-quality leads and drug development candidates for kinetoplastid diseases. Part 2: from molecule to confirmed hit 针对锥虫病的从高质量潜在客户和药物开发候选者出发的战略发现路线图。第二部分：从分子到确证活性分子 Sarah Hendrickx and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag110, https://doi.org/10.1093/jac/dkag110 VIRTUAL ROUNDTABLE（虚拟圆桌会议） 4 Diagnosis and risk factors for invasive mould disease—a round table discussion on directing antifungal therapy according to the available evidence 侵袭性霉菌病的诊断与危险因素——根据现有证据指导抗真菌治疗的圆桌讨论 Ana Alastruey-Izqueirdo and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag062, https://doi.org/10.1093/jac/dkag062 EDITORIALS, MESSAGES FROM THE OUTGOING AND INCOMING EDITORS-IN-CHIEF（社论、离任与就任主编寄语） 5 Message from the incoming Editor-in-Chief of JAC 《抗菌化疗杂志》就任主编寄语 Monica A Slavin Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkaf479, https://doi.org/10.1093/jac/dkaf479 6 Message from the outgoing Editor-in-Chief 离任主编寄语 J Peter Donnelly Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkaf480, https://doi.org/10.1093/jac/dkaf480 REVIEW（综述） 7 Experimental biofilm models for pharmacokinetic and pharmacodynamic investigations: bridging in vitro, ex vivo and in vivo systems 用于药代动力学和药效学研究的实验性生物膜模型：连接体外、离体和体内系统 Stephanie Supparitsch and Markus Zeitlinger Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag091, https://doi.org/10.1093/jac/dkag091 8 Antimicrobial therapy for infected necrotizing pancreatitis: microbiology, antimicrobial resistance and pharmacokinetics 感染性坏死性胰腺炎的抗菌治疗：微生物学、抗菌药物耐药性及药代动力学 Hannah S Pauw and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag092, https://doi.org/10.1093/jac/dkag092 9 Continuous linezolid infusion: the new way to dose, the old risks to fear 持续输注利奈唑胺：新的给药方式，仍需警惕旧有风险 Daniel Muñoz-Pichuante and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag100, https://doi.org/10.1093/jac/dkag100 10 Alignment of national standard treatment guidelines with WHO AWaRe recommendations for adult primary care infectious diseases: implications for antimicrobial stewardship 将国家标准治疗指南与世卫组织（WHO）针对成人初级保健传染病的“慎用、监测、备用”（AWaRe）推荐意见相统一：对抗菌药物管理的影响 Huda Arooj and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag099, https://doi.org/10.1093/jac/dkag099 SYSTEMATIC REVIEW（系统综述） 11 Healthcare providers’ experiences in caring for MDRO carriers with a focus on the moral dimensions of care: a systematic review 医疗服务提供者护理多重耐药菌（MDRO）携带者的经历——聚焦护理中的道德维度：一项系统综述 Carlijn Damsté and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag059, https://doi.org/10.1093/jac/dkag059 12 Extrapolation of oritavancin PK/PD targets to inform therapeutic drug monitoring: a systematic review 奥利他万星药代动力学/药效学目标的外推用以指导治疗药物监测：一项系统综述 Giammarco Baiardi and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag117, https://doi.org/10.1093/jac/dkag117 ORIGINAL RESEARCH（论著） 13 Beyond plasma: defining the translation value of epithelial lining fluid exposure profiles for the treatment of pneumonia 超越血浆：明确上皮衬里液暴露谱对肺炎治疗的转化价值 Yakun Fu and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkaf458, https://doi.org/10.1093/jac/dkaf458 14 Impact of loading dose β-lactam therapy on outcomes of KPC-producing Klebsiella pneumoniae bloodstream infections in non-ICU patients: a real world study 负荷剂量β-内酰胺类药物治疗非重症监护病房患者产KPC肺炎克雷伯菌血流感染的疗效影响：一项现实研究 Luisa Frallonardo and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag087, https://doi.org/10.1093/jac/dkag087 15 Rezafungin exhibits anti-biofilm properties against fungal biofilms in vitro 雷扎芬净在体外对真菌生物膜表现出抗生物膜特性 Hafsa Abduljalil and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag058, https://doi.org/10.1093/jac/dkag058 16 Vancomycin resistance predicts increased mortality in patients with Enterococcus faecium bloodstream infections: a six-year experience at a large tertiary care Italian hospital 万古霉素耐药性可预测屎肠球菌血流感染患者死亡率增加：意大利一家大型三级医院六年来的经验 Lucia Graziani and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag069, https://doi.org/10.1093/jac/dkag069 17 Fluoroquinolones and the risk of panic attacks: a systematic review and disproportionality analysis using individual case safety reports from the FDA Adverse Event Reporting System (FAERS) database 氟喹诺酮类药物与惊恐发作风险：基于美国食品药品监督管理局不良事件报告系统（FAERS）数据库中个体病例安全报告的系统综述和比例失衡分析 Keeirah Hiertika Raguram and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag083, https://doi.org/10.1093/jac/dkag083 18 Cefuroxime concentrations in facial artery musculomucosal flap, buccal submucosa, subcutaneous tissue, and plasma following bolus or continuous infusion in patients undergoing oral cancer resection: a randomized clinical microdialysis study 在接受口腔癌切除术的患者中，采用随机临床微透析研究，探究头孢呋辛在面动脉肌黏膜瓣、颊黏膜下层、皮下组织和血浆中的浓度（团注或持续输注后） Johanne Ravn Hansen and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag085, https://doi.org/10.1093/jac/dkag085 19 Infection point of care tests bridge the experience gap of antibiotic STOP decisions: clinicians versus students 感染即时检测可弥补抗生素停药决策方面的经验差距：临床医生与学生对比 Archit Singhal and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkaf486, https://doi.org/10.1093/jac/dkaf486 20 Functional analysis of a novel macrolide–lincosamide resistance gene erm(57) in Cutibacterium avidum 痤疮丙酸杆菌中一种新型大环内酯 - 林可酰胺类耐药基因erm(57)的功能分析 Juri Koizumi and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag029, https://doi.org/10.1093/jac/dkag029 21 HIV drug resistance amongst children and adolescents with viraemia in Lesotho and Tanzania: a nested analysis in the GIVE MOVE trial 莱索托和坦桑尼亚病毒血症儿童及青少年中的HIV耐药性：GIVE MOVE试验的嵌套分析 Christof Manuel Schönenberger and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag070, https://doi.org/10.1093/jac/dkag070 22 Identification and assessment of paediatric cefepime-induced neurotoxicity in a retrospective cohort of paediatric intensive care patients 在儿科重症监护患者回顾性队列中识别和评估儿科头孢吡肟诱导的神经毒性 Kathryn Pavia and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag075, https://doi.org/10.1093/jac/dkag075 23 Prioritization of adverse events related to integrase inhibitors and NNRTIs: a disproportionality analysis using data from the FAERS database 整合酶抑制剂和非核苷类逆转录酶抑制剂相关不良事件的优先级排序：基于FAERS数据库数据的比例失衡分析 Gao-yang Wang and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag074, https://doi.org/10.1093/jac/dkag074 24 Clinical and immunovirological status in children, adolescents and young adults with early-life-acquired HIV: a Spanish multi-cohort analysis since 2020 自2020年以来西班牙多队列分析中，儿童、青少年及青年时期感染HIV者的临床及免疫病毒学状态 Laura Tarancon-Diez and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag079, https://doi.org/10.1093/jac/dkag079 25 Population pharmacokinetics of meropenem in critically ill adult patients receiving extracorporeal membrane oxygenation—an ASAP ECMO study 接受体外膜肺氧合治疗的危重成年患者美罗培南的群体药代动力学——一项ASAP ECMO研究 Mohd H Abdul–Aziz and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag090, https://doi.org/10.1093/jac/dkag090 26 Evaluation of HIV-1 transmitted drug-resistance among subtypes circulating from 2022 to 2024 in Italy: a refined analysis through next-generation sequencing 2022年至2024年意大利流行HIV-1亚型间传播耐药性的评估：通过下一代测序技术进行的精细分析 Daniele Armenia and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag084, https://doi.org/10.1093/jac/dkag084 27 Characterization of efflux pump channel of florfenicol for resistance-enhancing variant RE-CmeABC in Campylobacter 耐药增强型变异体RE-CmeABC中氟苯尼考外排泵通道在弯曲菌中的特性研究 Hong Yao and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag047, https://doi.org/10.1093/jac/dkag047 28 Genomic characterization of colistin heteroresistance in Acinetobacter baumannii: Evidence for lpxD deletion and collateral sensitivity 鲍曼不动杆菌中黏菌素异质性耐药的基因组特征：lpxD缺失及附带敏感性的证据 Banu Sancak and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag076, https://doi.org/10.1093/jac/dkag076 29 Sustaining stewardship: longitudinal evaluation of an integrated antimicrobial programme in the ICU 持续管理：重症监护室（ICU）综合抗菌药物管理项目的纵向评估 Ashmitha Thomas and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag086, https://doi.org/10.1093/jac/dkag086 30 Global dissemination of optrA-mediated linezolid resistance in enterococci 利奈唑胺耐药性基因optrA介导的肠球菌在全球的传播 Jia Qi Beh and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag089, https://doi.org/10.1093/jac/dkag089 31 Predicting oral cephalosporin susceptibility in Escherichia coli blood isolates using parenteral cephalosporin susceptibility testing 利用肠外头孢菌素敏感性试验预测大肠杆菌血培养分离株对口服头孢菌素的敏感性 Tho H Pham and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag093, https://doi.org/10.1093/jac/dkag093 32 The pharmacodynamics of polymyxin B in Acinetobacter baumannii in murine thigh and lung infection models 在小鼠大腿和肺部感染模型中多粘菌素B对鲍曼不动杆菌的药效动力学研究 Sanne van den Berg and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag097, https://doi.org/10.1093/jac/dkag097 33 Genomic insights into the tmexCD-toprJ: plasmid-mediated evolution, dissemination and diversity in bacterial populations 关于tmexCD-toprJ的基因组见解：质粒介导的细菌群体进化、传播与多样性 Lilan Wan and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag107, https://doi.org/10.1093/jac/dkag107 34 Baseline resistance mutations and virological response to dolutegravir in treatment-naïve patients: a multicentre NGS study 初治患者基线耐药突变与多替拉韦病毒学应答：一项多中心下一代测序（NGS）研究 Alexy Inciarte and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag080, https://doi.org/10.1093/jac/dkag080 35 Novel integrase mutations linked to genotypic DTG resistance in African non-B HIV-1 strains: the DTG RESIST study 非洲非B型HIV-1毒株中与多替拉韦（DTG）基因型耐药相关的新型整合酶突变：DTG耐药研究 Nuri Han and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag088, https://doi.org/10.1093/jac/dkag088 36 Pharmacological evaluation of an ex vivo cervicovaginal HIV prevention model 体外宫颈阴道HIV预防模型的药理学评估 Lindsey B Collins and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag103, https://doi.org/10.1093/jac/dkag103 37 The magnitude of the pharmacodynamic index for NOSO-502: pathogen clearance, emergence of resistance and human dose predictions NOSO-502药效学指数的幅度：病原体清除、耐药性出现和人体剂量预测 Sanne van den Berg and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag106, https://doi.org/10.1093/jac/dkag106 38 Temocillin: a therapeutic alternative in bone and joint infections due to third generation cephalosporin-resistant Enterobacterales? 替莫西林：治疗第三代头孢菌素耐药肠杆菌目引起的骨关节感染的一种替代疗法？ Louise Piquart and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag105, https://doi.org/10.1093/jac/dkag105 39 Metallo-β-lactamase–producing Enterobacterales: cyanide-containing efflux pump inhibitors as potential dual-activity inhibitors 产金属β-内酰胺酶的肠杆菌科细菌：含氰化物的外排泵抑制剂作为潜在的双活性抑制剂 Otávio Hallal Ferreira Raro and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag122, https://doi.org/10.1093/jac/dkag122 40 Outer membrane vesicles transmit blaNDM-5 and package metallo-β-lactamases to promote antibiotic resistance in Escherichia coli 外膜囊泡传递blaNDM-5并包装金属β-内酰胺酶以促进大肠杆菌的抗生素耐药性 Ting-Yin Lu and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag123, https://doi.org/10.1093/jac/dkag123 41 Characterization of a ST412-K57 colistin-resistant hypervirulent Klebsiella pneumoniae strain of chicken origin 一株鸡源ST412-K57多粘菌素耐药高毒力肺炎克雷伯菌的特征分析 Qiu Xu and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag114, https://doi.org/10.1093/jac/dkag114 42 Olorofim in combination with azole antifungals: results from the Phase 2 salvage therapy study 奥罗芬明与唑类抗真菌药联合使用：2期挽救治疗研究结果 Johan Maertens and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag118, https://doi.org/10.1093/jac/dkag118 RESEARCH LETTER（研究快讯） 43 Infant HIV transmission despite maternal viral suppression: a case of post-weaning seroconversion 母体病毒得到抑制，婴儿仍发生HIV传播：一例断奶后血清转阳病例 Shadia Nakalema and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag072, https://doi.org/10.1093/jac/dkag072 44 Urinary antigen–negative Legionella pneumonia in critically ill patients: value of systematic molecular testing for optimal antimicrobial therapy 危重患者中尿抗原阴性军团菌肺炎：系统分子检测在优化抗菌治疗中的价值 Livia Foglia Manzillo and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag101, https://doi.org/10.1093/jac/dkag101 45 Contribution of SHV-1 overexpression to carbapenem resistance in a Klebsiella pneumoniae clinical isolate SHV-1过表达对某株肺炎克雷伯菌临床分离株碳青霉烯类抗生素耐药性的影响 Céline Plainvert and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag108, https://doi.org/10.1093/jac/dkag108 LETTER TO THE EDITOR（致编辑的信） 46 Comment on: Possible increased risk of Epstein–Barr virus (EBV) infection and posttransplant lymphoproliferative disease (PTLD) in letermovir-exposed haematopoietic cell transplantation recipients 评论：接受莱特莫韦治疗的造血细胞移植受者中，EB病毒（EBV）感染和移植后淋巴增殖性疾病（PTLD）的风险可能增加 Jan Styczynski Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag042, https://doi.org/10.1093/jac/dkag042 47 Comment on: Antimicrobial use for the treatment of bacterial sexually transmitted infections among doxycycline post-exposure prophylaxis users in Milan, Italy 评论：意大利米兰地区使用多西环素暴露后预防措施人群中针对细菌性性传播感染的抗菌药物使用情况 Luca Bortolani and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag023, https://doi.org/10.1093/jac/dkag023 48 Retrospective analysis of pharmacological therapeutic monitoring of caspofungin in patients undergoing continuous renal replacement therapy using polyacrylonitrile membranes—right to reply 使用聚丙烯腈膜进行连续肾脏替代治疗的患者中卡泊芬净药物治疗监测的回顾性分析——答复权 Antoine Hérault and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag095, https://doi.org/10.1093/jac/dkag095 49 Comment on: Temocillin versus other intravenous beta-lactams for urinary tract infections caused by third-generation cephalosporin-resistant Enterobacterales: a multicentre retrospective matched-cohort study 评论：替莫西林与其他静脉注射β-内酰胺类抗生素治疗第三代头孢菌素耐药肠杆菌目引起的尿路感染：一项多中心回顾性匹配队列研究 Shanshan Ru and Yingzhe Zhang Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag096, https://doi.org/10.1093/jac/dkag096 50 Comment on: Long-acting glycopeptides: what are the barriers to access in patients who need them most, and how can they be overcome? 评论：长效糖肽类抗生素：对于最需要它们的患者，获取的障碍是什么，如何克服？ Marco Bongiovanni Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag102, https://doi.org/10.1093/jac/dkag102 51 Comment on ‘Retrospective analysis of pharmacological therapeutic monitoring of caspofungin in patients undergoing continuous renal replacement therapy using polyacrylonitrile membranes’ 评论：“对使用聚丙烯腈膜进行连续肾脏替代治疗的患者中卡泊芬净的药理学治疗监测的回顾性分析” Julien Massol and Frédéric Baud Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag094, https://doi.org/10.1093/jac/dkag094 52 Comment on: ‘Epidemiology and treatment of endocarditis secondary to Enterobacterales other than Serratia spp’ 对“除塞拉蒂亚属（Serratia spp）外肠杆菌目所致心内膜炎的流行病学和治疗”的评论 Gianpiero Tebano and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag098, https://doi.org/10.1093/jac/dkag098 53 ‘Comparing serotype coverage of pneumococcal vaccines with PCV21 (V116), a new 21-valent conjugate pneumococcal vaccine, and the epidemiology of its eight unique Streptococcus pneumoniae serotypes (15A, 15C, 16F, 23A, 23B, 24F, 31 and 35B) causing invasive pneumococcal disease in adult patients in Canada: SAVE study, 2018–2021-right-to-reply’ “比较肺炎球菌疫苗的血清型覆盖率——PCV21（V116，一种新型21价结合肺炎球菌疫苗）与加拿大成人患者中导致侵袭性肺炎球菌疾病的其8种独特肺炎链球菌血清型（15A、15C、16F、23A、23B、24F、31和35B）的流行病学：SAVE研究，2018 - 2021年——回应” John J Schellenberg and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag126, https://doi.org/10.1093/jac/dkag126 54 Comment on: Antagonistic in vitro interaction between olorofim and voriconazole against Aspergillus fumigatus 评论：奥罗芬明与伏立康唑对烟曲霉的体外拮抗作用 Corinne Pinder and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag119, https://doi.org/10.1093/jac/dkag119 55 Epidemiology and treatment of endocarditis secondary to Enterobacterales other than Serratia spp.: right-to-reply 除塞氏杆菌属外肠杆菌科细菌所致心内膜炎的流行病学和治疗：回应 Sunish Shah and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 4, April 2026, dkag121, https://doi.org/10.1093/jac/dkag121 Journal of Antimicrobial Chemotherapy Volume 81, Issue 5抗菌化疗杂志81卷 5期 https://academic.oup.com/jac/issue 50TH ANNIVERSARY COLLECTION（50周年纪念合集） REVIEW（综述） 1 A strategic discovery roadmap towards high-quality leads and drug development candidates for kinetoplastid diseases. Part 1: setting the stage 针对动基体病的高质量先导化合物及药物开发候选物的战略发现路线图。第一部分：背景介绍 Sarah Hendrickx and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 5, May 2026, dkag109, https://doi.org/10.1093/jac/dkag109 REVIEW（综述） 2 Pathophysiology, risk factors and clinical management for polymyxin-associated acute kidney injury 多粘菌素相关急性肾损伤的病理生理学、危险因素及临床治疗 Simiao Zhao and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 5, May 2026, dkag132, https://doi.org/10.1093/jac/dkag132 SYSTEMATIC REVIEW（系统综述） 3 Definitions and rates of treatment failure in females with uncomplicated urinary tract infection: a systematic literature review 女性单纯性尿路感染治疗失败的定义及发生率：一项系统文献综述 Meghan E Luck and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 5, May 2026, dkag112, https://doi.org/10.1093/jac/dkag112 4 Therapeutic drug monitoring and the role of pharmacokinetics/pharmacodynamics in optimizing beta-lactam antibiotic dosing for deep-seated infections: a systematic review 在针对深部感染的β-内酰胺类抗生素优化给药方案中治疗药物监测以及药代动力学/药效学的作用：一项系统综述 Cassandra Vale and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 5, May 2026, dkag142, https://doi.org/10.1093/jac/dkag142 ORIGINAL RESEARCH（论著） 5 Optimizing cloxacillin prophylaxis in hip and knee arthroplasty based on population pharmacokinetics of unbound plasma concentrations 基于游离血浆浓度群体药代动力学优化髋关节和膝关节置换术中的氯唑西林预防用药方案 Gustaf Beijer and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 5, May 2026, dkag116, https://doi.org/10.1093/jac/dkag116 6 The tissue distribution and pharmacokinetics of [14C]-olorofim following intravenous dosing in the rat 大鼠静脉注射[14C]奥洛罗芬后的组织分布及药代动力学研究 Derek Law and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 5, May 2026, dkag120, https://doi.org/10.1093/jac/dkag120 7 Insights from the WHO Tricycle-aligned Fleming Fund EQASIA External Quality Assessment (EQA) programme detecting ESBL-, AmpC- and carbapenemase-producing Escherichia coli in South and South-East Asia 世界卫生组织三轮车项目（Tricycle）协同的弗莱明基金南亚和东南亚地区外部质量评估（EQASIA EQA）计划在检测南亚和东南亚地区产超广谱β-内酰胺酶（ESBL）、AmpC酶和碳青霉烯酶的大肠埃希菌方面的见解 Hiba Al-Mir and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 5, May 2026, dkag129, https://doi.org/10.1093/jac/dkag129 8 The plasma and intracellular exposure of intramuscularly administered long-acting cabotegravir and rilpivirine in people with HIV HIV感染者肌内注射长效卡博特韦和利匹韦林后的血浆及细胞内暴露情况 Micol Ferrara and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 5, May 2026, dkag113, https://doi.org/10.1093/jac/dkag113 9 In vitro synergistic activity of minocycline and biapenem against cefiderocol-resistant New Delhi metallo-β-lactamase-producing Enterobacterales 米诺环素与比阿培南在体外对产新德里金属β-内酰胺酶且对头孢地尔耐药的肠杆菌科细菌的协同作用 Takashi Okanda and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 5, May 2026, dkag128, https://doi.org/10.1093/jac/dkag128 10 Mortality risk of ESBL producers in Escherichia coli bacteraemia: a comprehensive analysis using the PROBAC cohort 产超广谱β-内酰胺酶大肠埃希菌菌血症的死亡风险：基于PROBAC队列的综合分析 Paula Olivares-Navarro and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 5, May 2026, dkag130, https://doi.org/10.1093/jac/dkag130 11 Molecular mechanism of envZ regulating β-lactam antibiotic resistance and virulence in Escherichia coli EnvZ调控大肠埃希菌β-内酰胺类抗生素耐药性及毒力的分子机制 Kun Yang and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 5, May 2026, dkag104, https://doi.org/10.1093/jac/dkag104 12 In vitro activity of amoxicillin combined with oral cephalosporins against endocarditis-associated E. faecalis clinical isolates 阿莫西林联合口服头孢菌素针对心内膜炎相关粪肠球菌临床分离株的体外活性 David Luque Paz and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 5, May 2026, dkag127, https://doi.org/10.1093/jac/dkag127 13 Genome-wide association studies builds a predictive model and reveals novel resistance features for macrolide-resistant Bordetella pertussis 全基因组关联研究构建预测模型并揭示大环内酯类耐药百日咳鲍特菌的新耐药特征 Jialiang Chen and Guowei Liang Journal of Antimicrobial Chemotherapy, Volume 81, Issue 5, May 2026, dkag131, https://doi.org/10.1093/jac/dkag131 14 Real-world validation of a reduced-dose continuous infusion cefepime regimen: pharmacodynamic target attainment, efficacy and neurotoxicity 减量持续静脉输注头孢吡肟方案的实际应用验证：药效学目标达成情况、疗效及神经毒性 Kieffer Korvin and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 5, May 2026, dkag138, https://doi.org/10.1093/jac/dkag138 15 Cross-species and cross-border spread of aph(3′)-ia-mediated neomycin resistance in Escherichia coli from animals: a genomic perspective 从基因组角度研究动物源大肠杆菌中aph(3′)-ia介导的新霉素耐药性的跨物种和跨国传播 Mattia Pirolo and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 5, May 2026, dkag143, https://doi.org/10.1093/jac/dkag143 16 Prevalence of cyp51A variants in a US collection of Aspergillus fumigatus clinical isolates and comparative analysis of their contribution to triazole antifungal resistance 美国烟曲霉临床分离株集合中cyp51A变异体的流行情况及其对三唑类抗真菌药物耐药性作用的比较分析 Luisa Fernanda Gómez Londoño and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 5, May 2026, dkag124, https://doi.org/10.1093/jac/dkag124 17 In vitro and in vivo activity of daptomycin plus ceftaroline for the treatment of experimental endocarditis due to Enterococcus faecalis with and without high-level aminoglycoside resistance 达托霉素联合头孢洛林对高水平氨基糖苷类耐药及非耐药粪肠球菌所致实验性心内膜炎的体内外疗效研究 María-Alexandra Cañas and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 5, May 2026, dkag136, https://doi.org/10.1093/jac/dkag136 18 Pharmacokinetics of a three-dose regimen of intramuscular benzathine penicillin G in pregnant women with syphilis 三剂苄星青霉素G肌内注射方案在妊娠期梅毒患者中的药代动力学研究 Eshetie Melese Birru and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 5, May 2026, dkag145, https://doi.org/10.1093/jac/dkag145 19 Cefiderocol resistance mediated by mutation of the miniconductance mechanosensitive channel MscM in Klebsiella oxytoca 由产气克雷伯菌中微小电导机械敏感通道MscM发生突变所介导的头孢地尔耐药性 Pia Turowski and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 5, May 2026, dkag147, https://doi.org/10.1093/jac/dkag147 20 The veterinary clinic backyard lawn used for relief walks of hospitalized dogs is a hotspot for OXA-type carbapenemases in multiple Enterobacterales 兽医诊所后院供住院犬只散步的草坪是多种肠杆菌科细菌中OXA型碳青霉烯酶的传播热点区域 Yvonne Spahr and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 5, May 2026, dkag144, https://doi.org/10.1093/jac/dkag144 21 Pharmacokinetics of cefazolin in bariatric surgery patients: a preoperative perspective 头孢唑林在减肥手术患者中的药代动力学：术前视角 Alexandra Porlier and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 5, May 2026, dkag150, https://doi.org/10.1093/jac/dkag150 RESEARCH LETTERS（研究快讯） 22 Plasmid-encoded FRI-10 carbapenemase harboured by non-Enterobacter species isolated from a wastewater sample in Tokyo, Japan 从日本东京废水样本中分离出的非肠杆菌科物种携带质粒编码的FRI-10碳青霉烯酶 Kou Murakami and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 5, May 2026, dkag133, https://doi.org/10.1093/jac/dkag133 23 Synergistic activity of cefepime/enmetazobactam with meropenem, piperacillin, piperacillin/tazobactam, cefiderocol and fosfomycin against Klebsiella pneumoniae carrying blaKPC allelic variants 头孢吡肟/恩美唑巴坦与美罗培南、哌拉西林、哌拉西林/他唑巴坦、西他沙星和磷霉素针对携带blaKPC等位基因变体的肺炎克雷伯菌的协同作用 Alice Crema and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 5, May 2026, dkag141, https://doi.org/10.1093/jac/dkag141 24 MRSA and carbapenem-resistant Acinetobacter baumannii on the fall: successful infection prevention and control in Chilean ICUs 耐甲氧西林金黄色葡萄球菌和耐碳青霉烯类鲍曼不动杆菌数量下降：智利重症监护病房感染预防与控制的成功案例 Patricio Ross and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 5, May 2026, dkag146, https://doi.org/10.1093/jac/dkag146 LETTER TO THE EDITOR（致编辑的信） 25 Comment on: Model-based assessment of VRC07-523LS dosing in infants through population pharmacokinetic–pharmacodynamic modelling in adults and infants 评论：基于模型的评估VRC07-523LS在婴儿中的给药剂量——基于成人和婴儿群体药代动力学-药效学模型 Wanhua Qiu Journal of Antimicrobial Chemotherapy, Volume 81, Issue 5, May 2026, dkag139, https://doi.org/10.1093/jac/dkag139 26 Comment on: Comparing serotype coverage of pneumococcal vaccines with PCV21 (V116), a new 21-valent conjugate pneumococcal vaccine, and the epidemiology of its eight unique Streptococcus pneumoniae serotypes (15A, 15C, 16F, 23A, 23B, 24F, 31 and 35B) causing invasive pneumococcal disease in adult patients in Canada: SAVE study, 2018–21 评论：比较含21种血清型的肺炎球菌疫苗PCV21（V116）（一种新型21价结合肺炎球菌疫苗）的血清型覆盖范围，以及2018 - 2021年SAVE研究中导致加拿大成年患者侵袭性肺炎球菌疾病的8种独特肺炎链球菌血清型（15A、15C、16F、23A、23B、24F、31和35B）的流行病学情况 Gokul Raj Pullagura and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 5, May 2026, dkag125, https://doi.org/10.1093/jac/dkag125 27 Comment on: Distinct population structure and genomic context of NarAB between broiler and human clinical Enterococcus isolates 评论：肉鸡源和人临床来源肠球菌分离株中NarAB的不同种群结构和基因组背景 Alex Wong Journal of Antimicrobial Chemotherapy, Volume 81, Issue 5, May 2026, dkag134, https://doi.org/10.1093/jac/dkag134 28 Distinct population structure and genomic context of narAB between broiler and human clinical Enterococcus isolates—authors’ response 肉鸡源和人临床来源肠球菌分离株中narAB的不同种群结构和基因组背景——作者回复 Jayanth Balakuntla and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 5, May 2026, dkag135, https://doi.org/10.1093/jac/dkag135 Journal of Antimicrobial Chemotherapy Volume 81, Issue 6抗菌化疗杂志81卷 6期 https://academic.oup.com/jac/issue 50TH ANNIVERSARY COLLECTION（50周年纪念合集） REVIEW（综述） 1 A strategic discovery roadmap towards high-quality leads and drug development candidates for kinetoplastid diseases. Part 3: from lead towards a drug development candidate 针对动基体疾病高质量先导化合物和药物开发候选物的战略发现路线图。第三部分：从先导化合物到药物开发候选物 Sarah Hendrickx and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 6, June 2026, dkag111, https://doi.org/10.1093/jac/dkag111 ORIGINAL RESEARCH（原创研究） 2 Population pharmacokinetics and probability of target attainment of tigecycline in critically ill children 危重患儿中替加环素（Tigecycline）的群体药代动力学及目标达成概率研究 Wenjuan Hu and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 6, June 2026, dkag156, https://doi.org/10.1093/jac/dkag156 3 Phenotypic and genotypic characterization of HMB-3, a metallo-beta-lactamase from Pseudomonas asiatica 假单胞菌属亚洲种（Pseudomonas asiatica）中金属β-内酰胺酶HMB-3的表型和基因型特征 Jacqueline Findlay and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 6, June 2026, dkag148, https://doi.org/10.1093/jac/dkag148 4 Early adequate linezolid concentrations and clinical outcomes in confirmed Gram-positive infections: the role of therapeutic drug monitoring 确诊的革兰氏阳性菌感染中早期达到适宜利奈唑胺浓度与临床预后的关系：治疗药物监测的作用 Daniel Fresán and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 6, June 2026, dkag137, https://doi.org/10.1093/jac/dkag137 5 Monte Carlo simulations identify suboptimal PK/PD target attainment with standard maribavir dosing 蒙特卡洛模拟表明标准剂量马立巴韦的药动学/药效学靶标达成情况欠佳 Yeleen Fromage and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 6, June 2026, dkag153, https://doi.org/10.1093/jac/dkag153 6 Exploring the pharmacokinetic mechanisms that affect bictegravir exposure during pregnancy 探究妊娠期间影响比克替拉韦暴露的药代动力学机制 L van der Wekken-Pas and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 6, June 2026, dkag159, https://doi.org/10.1093/jac/dkag159 7 Artificial intelligence for analysing antibiotic use: an exploratory study in a tertiary care paediatric hospital in Italy 人工智能用于分析抗生素使用情况：意大利一家三级儿科医院的探索性研究 Elio Castagnola and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 6, June 2026, dkag162, https://doi.org/10.1093/jac/dkag162 8 Antimicrobial activity of aztreonam–avibactam against KPC variant-producing Klebsiella pneumoniae with ceftazidime–avibactam resistance 氨曲南-阿维巴坦对产KPC变异体且对头孢他啶-阿维巴坦耐药的肺炎克雷伯菌的抗菌活性 Jingchun Kong and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 6, June 2026, dkag152, https://doi.org/10.1093/jac/dkag152 9 Highly transformable Haemophilus influenzae as a potential amplifier of quinolone resistance dissemination 高转化型流感嗜血杆菌作为喹诺酮耐药性传播的潜在放大器 Takeaki Wajima and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 6, June 2026, dkag160, https://doi.org/10.1093/jac/dkag160 10 Comparative nephrotoxicity of polymyxin B versus colistin: evidence from ensemble learning and propensity score matching 多黏菌素B与黏菌素的肾毒性比较：来自集成学习和倾向评分匹配的证据 Murat Özdede and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 6, June 2026, dkag044, https://doi.org/10.1093/jac/dkag044 11 Emulating a target trial of early compared with late initiation of appropriate antibiotic therapy for hospital-acquired monobacterial Gram-negative bloodstream infections 模拟医院获得性单菌革兰氏阴性菌血流感染早期与晚期开始恰当抗生素治疗的对照试验 Abdullah T Aslan and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 6, June 2026, dkag161, https://doi.org/10.1093/jac/dkag161 12 Flufenamic acid resensitizes MRSA to gentamicin through synergistic ion modulation 氟苯尼考通过协同离子调节使MRSA对庆大霉素重新敏感 Xiaomin Ren and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 6, June 2026, dkag154, https://doi.org/10.1093/jac/dkag154 13 Description of OXA-244 carbapenemase-producing Escherichia coli in farm animals in The Netherlands, 2024 2024年荷兰农场动物中OXA-244碳青霉烯酶产大肠杆菌的描述 K T Veldman and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 6, June 2026, dkag155, https://doi.org/10.1093/jac/dkag155 14 Clinical outcomes of beta-bactam monotherapy versus beta-lactam plus azithromycin in hospitalized patients with community-acquired pneumoniae β-内酰胺类单药治疗与β-内酰胺类联合阿奇霉素治疗社区获得性肺炎住院患者的临床预后比较 Ilona Zhygalova Zhygalova and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 6, June 2026, dkag158, https://doi.org/10.1093/jac/dkag158 15 ‘Leaving no stones unturned’: up to 10 years results on the effectiveness, tolerability and metabolic safety of dolutegravir+lamivudine (DTG+3TC) as a switch regimen in the ODOACRE cohort "不遗余力"：ODOACRE队列中多替拉韦+拉米夫定（DTG+3TC）作为转换方案长达10年的有效性、耐受性及代谢安全性结果 Arturo Ciccullo and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 6, June 2026, dkag172, https://doi.org/10.1093/jac/dkag172 16 Evaluation of a novel lateral flow immunochromatographic assay, Certest ResisCheck® Carbapenemases, for the rapid detection and differentiation of carbapenemase in Gram-negative bacteria from bacterial culture 新型侧向流免疫层析检测试剂Certest ResisCheck® Carbapenemases用于革兰氏阴性菌培养物中碳青霉烯酶快速检测与鉴别的评估 Laura Monge-Olivares and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 6, June 2026, dkag149, https://doi.org/10.1093/jac/dkag149 17 Temocillin efficacy and emergence of resistance in Enterobacter cloacae Complex in a murine peritonitis model 替莫西林对产气肠杆菌复合群的疗效及耐药性演变：小鼠腹膜炎模型研究 N Alanbari and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 6, June 2026, dkag151, https://doi.org/10.1093/jac/dkag151 18 Temporal association between aerosolized colistin use and colistin resistance in the ICU: a time-series analysis ICU中雾化粘菌素使用与粘菌素耐药之间的时间关联：一项时间序列分析 Weechang Kang and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 6, June 2026, dkag169, https://doi.org/10.1093/jac/dkag169 19 Can antimicrobial stewardship programmes be implemented during an armed conflict? A retrospective interventional cohort study 武装冲突期间能否实施抗菌药物管理计划？一项回顾性干预性队列研究 Hailie D Uren and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 6, June 2026, dkag115, https://doi.org/10.1093/jac/dkag115 20 Voriconazole therapy and CYP2C19 phenotype: identifying patients who may need alternative antifungal therapy 伏立康唑治疗与CYP2C19表型：识别可能需要替代抗真菌治疗的患者 Eman Wehbe and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 6, June 2026, dkag168, https://doi.org/10.1093/jac/dkag168 21 Impact of cardiopulmonary bypass on cefuroxime plasma and interstitial tissue concentrations in patients undergoing cardiac bypass surgery—a prospective controlled clinical trial 体外循环对心脏旁路手术患者头孢呋辛血浆及组织间质浓度的影响——一项前瞻性对照临床试验 Stefanie Nothofer and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 6, June 2026, dkag171, https://doi.org/10.1093/jac/dkag171 22 Population pharmacokinetic analysis and dosing regimen optimization of eravacycline in critically ill patients with carbapenem-resistant Acinetobacter baumannii pneumonia 对碳青霉烯耐药鲍曼不动杆菌肺炎危重患者中埃拉环素的药代动力学分析及给药方案优化 Luqi Lou and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 6, June 2026, dkag178, https://doi.org/10.1093/jac/dkag178 23 Durability and mechanistic performance of aztreonam/avibactam versus aztreonam plus ceftazidime/avibactam against Stenotrophomonas maltophilia complex 氨曲南/阿维巴坦与氨曲南联合头孢他啶/阿维巴坦对抗嗜麦芽窄食单胞菌复合群的耐久性和机制性能比较 Ashlan J Kunz Coyne and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 6, June 2026, dkag177, https://doi.org/10.1093/jac/dkag177 24 High-dose daptomycin for the treatment of invasive infections due to Enterococcus faecalis isolates with intermediate susceptibility 高剂量达托霉素治疗粪肠球菌中介敏感株所致侵袭性感染的疗效 Sidney Drake and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 6, June 2026, dkag179, https://doi.org/10.1093/jac/dkag179 25 Updated mapping of Plasmodium falciparum kelch13 gene polymorphisms in Madagascar, 2024 2024年马达加斯加恶性疟原虫kelch13基因多态性的最新图谱更新 Camille Roesch and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 6, June 2026, dkag181, https://doi.org/10.1093/jac/dkag181 26 Efficacy of ceftazidime/avibactam against 10 clinical isolates of Pseudomonas aeruginosa in icodextrin-based peritoneal dialysis solution and patient-derived dialysate 头孢他啶/阿维巴坦针对icodextrin基腹膜透析液及患者来源透析液中10株铜绿假单胞菌临床分离株的抗菌活性 Stephanie Supparitsch and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 6, June 2026, dkag185, https://doi.org/10.1093/jac/dkag185 27 Cefiderocol activity against multidrug-resistant isolates from the PERSEUS study: relationship between cefiderocol minimum inhibitory concentration and clinical outcomes 头孢德罗对PERSEUS研究中多重耐药分离株的抗菌活性：头孢德罗最低抑菌浓度与临床预后之间的关系 Rafael Cantón and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 6, June 2026, dkag164, https://doi.org/10.1093/jac/dkag164 28 Class 1 DISARM system in restriction of conjugative carbapenemase-encoding plasmids in Klebsiella pneumoniae sequence type 23 1类DISARM系统对肺炎克雷伯菌ST23中接合型碳青霉烯酶编码质粒的限制作用 Qingqing Du and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 6, June 2026, dkag167, https://doi.org/10.1093/jac/dkag167 29 Acute kidney injury following amikacin therapy: a retrospective cohort study 阿米卡星治疗后急性肾损伤：一项回顾性队列研究 Iris Zohar and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 6, June 2026, dkag188, https://doi.org/10.1093/jac/dkag188 30 Performance of EUCAST disc diffusion and supplementary methods to detect reduced susceptibility to linezolid in enterococci— the NordicAST LRE-study EUCAST纸片扩散法及补充方法检测肠球菌利奈唑胺低敏感性的表现——NordicAST LRE研究 Bjørg Christina Haldorsen and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 6, June 2026, dkag174, https://doi.org/10.1093/jac/dkag174 31 In vitro exposure to non-antipseudomonal antibiotics (NAPA) induces Pseudomonas aeruginosa resistance to antipseudomonal antibiotics (APA) 体外暴露于非抗假单胞菌抗生素（NAPA）可诱导铜绿假单胞菌对抗假单胞菌抗生素（APA）产生耐药性 David Lasry and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 6, June 2026, dkag182, https://doi.org/10.1093/jac/dkag182 32 Sub-inhibitory polyether ionophores enhance resistance plasmid transfer and transiently perturb the broiler gut resistome 亚抑制浓度的聚醚离子载体可促进耐药质粒转移并暂时扰乱肉鸡肠道耐药组 Jingyue Yang and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 6, June 2026, dkag190, https://doi.org/10.1093/jac/dkag190 33 Influence of a putative TonB-dependent receptor on cefiderocol susceptibility in clinical Enterobacter hormaechei isolates 推测的TonB依赖性受体对临床肠杆菌hormaechei分离株中头孢地尔敏感性的影响 Pia Turowski and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 6, June 2026, dkag193, https://doi.org/10.1093/jac/dkag193 RESEARCH LETTERS（研究快报） 34 Early bictegravir failure and emergence of R263K-mediated class-wide HIV integrase inhibitors resistance linked to over-the-counter supplement use 比克替拉韦早期治疗失败与R263K介导的与非处方补充剂使用相关的全类HIV整合酶抑制剂耐药的出现 Elisa Minacori and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 6, June 2026, dkag157, https://doi.org/10.1093/jac/dkag157 35 Environmental benefits of switching from intravenous to oral administration of ciprofloxacin 环丙沙星从静脉给药转换为口服给药的环境效益 Nicolas De Jaegher and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 6, June 2026, dkag163, https://doi.org/10.1093/jac/dkag163 36 Macrolide resistance via 23S rRNA gene mutation in Corynebacterium ulcerans 白喉棒状杆菌通过23S rRNA基因突变介导的大环内酯类耐药 Chiara Crestani and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 6, June 2026, dkag166, https://doi.org/10.1093/jac/dkag166 37 Prosthesis-associated Burkholderia cepacia complex infection managed with sequential directed therapy including ceftolozane/tazobactam 采用包括头孢妥仑/他唑巴坦在内的序贯导向疗法治疗假体相关洋葱伯克霍尔德菌复合感染 Elia Asensi-Díaz and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 6, June 2026, dkag165, https://doi.org/10.1093/jac/dkag165 38 Drug interactions and kidney safety of bictegravir/emtricitabine/tenofovir alafenamide in kidney transplant recipients with HIV: an interventional pilot study 比克替拉韦/恩曲他滨/丙酚替诺福韦在合并HIV的肾移植受者中的药物相互作用及肾脏安全性：一项干预性 pilot 研究 Thomas Stehlé and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue 6, June 2026, dkag176, https://doi.org/10.1093/jac/dkag176 39 Harmonizing antimicrobial susceptibility testing: a comparison of CLSI and EUCAST categorizations 抗菌药物敏感性试验的协调：CLSI与EUCAST分类法的比较 Eric Farfour and Marie Lavollay Journal of Antimicrobial Chemotherapy, Volume 81, Issue 6, June 2026, dkag081, https://doi.org/10.1093/jac/dkag081 LETTER TO THE EDITOR（致编辑的信） 40 Comment on: Impact of loading dose β-lactam therapy on outcomes of KPC-producing Klebsiella pneumoniae bloodstream infections in non-ICU patients: a real world study 对"负荷剂量β-内酰胺类治疗对非ICU患者产KPC肺炎克雷伯菌血流感染结局的影响：一项现实研究"的评论 Xuefeng Yu Journal of Antimicrobial Chemotherapy, Volume 81, Issue 6, June 2026, dkag173, https://doi.org/10.1093/jac/dkag173 41 Comment on: ‘Cooperation between HIV-1 integrase natural polymorphism K156N and 3′PPT mutations in dolutegravir monotherapy failure’ 评论："HIV-1整合酶天然多态性K156N与3′PPT突变在多替拉韦单药治疗失败中的协同作用" Muhammad Ifham Hanif and Mentari Maratus Sholihah Journal of Antimicrobial Chemotherapy, Volume 81, Issue 6, June 2026, dkag175, https://doi.org/10.1093/jac/dkag175 Journal of Antimicrobial Chemotherapy Volume 81, Issue Supplement_1抗菌化疗杂志81卷增刊1期 https://academic.oup.com/jac/issue/81/Supplement_1?login=false SUPPLEMENT（增刊） Breaking Evidence and Insights into Effective Utilization and Implementation of Procalcitonin 降钙素原有效利用与实施的突破性证据与见解 VIRTUAL ROUNDTABLE（线上圆桌论坛） 1 Procalcitonin in the management of lower respiratory tract infection and sepsis 降钙素原在下呼吸道感染和脓毒症治疗中的应用 Ramy H Elshaboury and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue Supplement_1, June 2026, Pages i1–i5, https://doi.org/10.1093/jac/dkaf298 VIEWPOINT（观点） 2 Beyond the algorithm: reframing biomarker-guided antibiotic stewardship with behavioural insights 超越算法：以行为学见解重构生物标志物导向的抗菌药物管理 Patrycja Sleboda and others Journal of Antimicrobial Chemotherapy, Volume 81, Issue Supplement_1, June 2026, Pages i6–i8, https://doi.org/10.1093/jac/dkag140 CORRECTION（更正） 3 Correction to: Procalcitonin in the management of lower respiratory tract infection and sepsis 更正：降钙素原在下呼吸道感染和脓毒症治疗中的应用 Journal of Antimicrobial Chemotherapy, Volume 81, Issue Supplement_1, June 2026, Page i9, https://doi.org/10.1093/jac/dkag170

2026-06-23

·北京医学感染与传染研究

传染病杂志 233卷 1-6期、增刊1期（2026年6月23日更新）

The Journal of Infectious Diseases. Volume 233 Issue 1 传染病杂志 233卷 1期 https://academic.oup.com/jid/issue/ Editorial（社论） 1 Virulent Bacteriophages for Controlling Shiga Toxin–Producing Escherichia coli (STEC) Without Inducing Toxin Production 用于控制产志贺毒素大肠杆菌（STEC）且不诱导毒素产生的烈性噬菌体 Glen D Armstrong The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 1–2, https://doi.org/10.1093/infdis/jiaf036 Invited Perspective（特邀观点） 2 With All Good Intentions: How CDC Decisions Harmed Science and People John Weiser 好心办坏事：美国疾控中心（CDC）的决策如何损害了科学和民众 The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 3–5, https://doi.org/10.1093/infdis/jiaf584 Perspectives（观点） 3 Persistence Is Resistance: The Fight to End the HIV Epidemic Hangs in the Balance 坚持即抵抗：结束艾滋病流行的斗争悬而未决 Colleen F Kelley and others The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 6–8, https://doi.org/10.1093/infdis/jiaf389 Special Collection on Contemporary Research on Antimicrobial Resistance（抗菌药物耐药性当代研究特辑） Call for Papers: Antimicrobial Resistance（征稿启事：抗菌药物耐药性） 4 How Pooled Procurement Can Expand Access to Novel Antibacterial Therapeutics Globally 集中采购如何在全球范围内扩大新型抗菌疗法的可及性 Jessica Swenson The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 9–15, https://doi.org/10.1093/infdis/jiaf370 5 Pharmacokinetics and Safety of Clofazimine in Women With Rifampicin-resistant Tuberculosis During Pregnancy and the Postpartum Period: Results From IMPAACT P1026s 妊娠期及产后利福平耐药结核病女性患者使用氯法齐明的药代动力学和安全性：IMPAACT P1026s研究结果 Jennifer A Hughes and others The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 16–26, https://doi.org/10.1093/infdis/jiaf504 6 Emergence of ST3390: A Novel Apigmented MRSA Clone From the CC5 Lineage ST3390的出现：源自CC5谱系的一种新型非色素性耐甲氧西林金黄色葡萄球菌克隆 Emily A Felton and others The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 27–37, https://doi.org/10.1093/infdis/jiaf410 7 Establishing a Practical Approach to Sewer Monitoring for Antimicrobial Resistance Genes and Organisms at Healthcare Facilities 建立医疗机构针对抗菌药物耐药基因和耐药菌的污水监测实用方法 Rachel S Poretsky and others The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 38–48, https://doi.org/10.1093/infdis/jiaf434 8 Real-world Prevalence of Nonintegrase INSTI Resistance-Associated Mutations and Virological Outcomes in People Who Have Recently Acquired HIV-1 in the United Kingdom 英国近期感染HIV-1人群中非整合酶INSTI耐药相关突变的现实流行率及病毒学结果 Christine Kelly and others The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 49–58, https://doi.org/10.1093/infdis/jiaf500 9 Detection of Carbapenem-Resistant Bacteria in Skilled Nursing Facility Wastewater 在专业护理机构废水中检测碳青霉烯类耐药细菌 Susanna Lenz and others The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 59–69, https://doi.org/10.1093/infdis/jiaf534 10 Investigating Azithromycin Activity Against ESBL-Producing Escherichia coli Under Physiologically Relevant Conditions 在生理相关条件下研究阿奇霉素对产超广谱β-内酰胺酶大肠杆菌的活性 Sean Jung and others The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 70–75, https://doi.org/10.1093/infdis/jiaf480 ID Translational Science Update（传染病转化医学更新） 11 Planning and Analyzing a Low-Biomass Microbiome Study: A Data Analysis Perspective 低生物量微生物组研究的规划与分析：数据分析视角 George I Austin and Tal Korem The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 76–86, https://doi.org/10.1093/infdis/jiae378 Major Articles and Brief Reports（主要论著和简短报告） Bacterial Disease Pathogenesis（细菌性疾病发病机制） 12 Virulent Bacteriophages for Controlling Shiga Toxin–Producing Escherichia coli Without Inducing Toxin Production 用于控制产志贺毒素大肠杆菌（STEC）且不诱导毒素产生的烈性噬菌体 Eunshin Cho and others The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 87–95, https://doi.org/10.1093/infdis/jiaf035 13 Hygromycin A Treatment of Borrelia burgdorferi–Infected Peromyscus leucopus Suggests Potential as a Reservoir-Targeted Antibiotic 对伯氏疏螺旋体感染的白足鼠使用潮霉素A治疗，提示其作为针对储存宿主抗生素的潜在作用 Stephanie S You and others The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 96–100, https://doi.org/10.1093/infdis/jiaf363 14 Low Intrinsic Killing Activity and no Impact of Its Positivity on Phase 3 Pneumococcal Vaccine Adult Studies 固有杀菌活性低，且其阳性对3期肺炎球菌疫苗成人研究无影响 Weifeng Xu and others The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 101–111, https://doi.org/10.1093/infdis/jiaf427 15 Population Structure of Escherichia coli Isolated From the Human Bloodstream, Human and Animal Feces, and the Environment in Northern Tanzania 坦桑尼亚北部从人体血液、人和动物粪便以及环境中分离出的大肠杆菌的种群结构 Deng B Madut and others The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 112–121, https://doi.org/10.1093/infdis/jiaf437 Viral Disease Pathogenesis（病毒性疾病发病机制） 16 Evaluating the Breadth and Reliability of Influenza Vaccine Protection Indicators: A Secondary Analysis of an Animal Challenge Trial 评估流感疫苗保护指标的广度和可靠性：动物挑战试验的二次分析 Yao Lu and others The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 122–131, https://doi.org/10.1093/infdis/jiaf331 17 Assessing the Transmissibility and Outbreak Risk of Measles in the United States, 2024–2030 评估2024 - 2030年美国麻疹的传播性和暴发风险 Subekshya Bidari and others The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 132–136, https://doi.org/10.1093/infdis/jiaf342 18 Coronavirus Disease 2019 Risk in Patients With Autoimmune Diseases Using Biologics or Small Molecules: A Population-Based Cohort Study 使用生物制剂或小分子药物治疗的自身免疫性疾病患者感染2019冠状病毒病的风险：一项基于人群的队列研究 Eun Mi Song and others The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 137–147, https://doi.org/10.1093/infdis/jiaf347 19 Leveraging Lyme Disease Surveillance to Simulate Powassan Virus Prevalence 利用莱姆病监测来模拟伯氏疏螺旋体脑炎病毒流行率 James M McCluskey and others The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 148–152, https://doi.org/10.1093/infdis/jiaf368 20 Human Metapneumovirus–, Respiratory Syncytial Virus–, and Influenza-Associated Pneumonia Hospitalizations in Colorado Adults Aged ≥50 Years, 2016–2023 2016 - 2023年科罗拉多州50岁及以上成年人中与人类偏肺病毒、呼吸道合胞病毒和流感相关的肺炎住院情况 Eric A F Simões and others The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 153–163, https://doi.org/10.1093/infdis/jiaf381 Malaria Disease Pathogenesis（疟疾发病机制） 21 Digital PCR Reveals High PvDBP1 but not PvEBP/DBP2 and PvRBP2b Copy Number in Plasmodium vivax From Duffy-Negative Individuals in Central Africa 数字PCR显示，在非洲中部杜菲血型阴性个体中，恶性疟原虫的PvDBP1拷贝数高，但PvEBP/DBP2和PvRBP2b拷贝数不高 Bernis Neneyoh Yengo and others The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 164–172, https://doi.org/10.1093/infdis/jiaf322 22 Elevated Soluble Urokinase-Type Plasminogen Activator Receptor Levels, Organ Dysfunction, and Death in Children Hospitalized With Malaria: Considerations for Use as a Risk Stratification Tool 疟疾住院儿童中可溶性尿激酶型纤溶酶原激活物受体水平升高、器官功能障碍和死亡：作为风险分层工具的考量 Charles Ssuuna and others The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 173–177, https://doi.org/10.1093/infdis/jiaf327 23 Vaccine-Induced Antibodies to a C-Terminal Plasmodium falciparum Circumsporozoite Protein Epitope Associated With Protection Against Malaria Challenge 疫苗诱导产生的针对疟原虫环子孢子蛋白C端表位的抗体与对疟疾挑战的保护作用相关 DeAnna J Friedman-Klabanoff and others The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 178–190, https://doi.org/10.1093/infdis/jiaf391 24 Cytokines Associated With Moderate and Severe Adverse Events During a Sporozoite Malaria Vaccine Trial With Controlled Human Malaria Infection 在受控人体疟疾感染的孢子虫疟疾疫苗试验中，与中度和重度不良事件相关的细胞因子 Lauren P Jatt and others The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 191–196, https://doi.org/10.1093/infdis/jiaf435 Global Health（全球健康） 25 HIV and Syphilis Coinfection in Pregnancy and Adverse Birth Outcomes in Uganda 乌干达妊娠期HIV和梅毒合并感染与不良出生结局 Mehal Churiwal and others The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 197–205, https://doi.org/10.1093/infdis/jiaf453 26 Antibodies to Tick Salivary Antigens AV422 and Calreticulin in Patients With Spotted Fever Group Rickettsioses and Other Febrile Illnesses in Northern Tanzania 坦桑尼亚北部斑点热群立克次体病及其他发热性疾病患者体内针对蜱唾液抗原AV422和钙网织蛋白的抗体 Ganga S Moorthy and others The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 206–215, https://doi.org/10.1093/infdis/jiaf506 27 Virological Tools Fail to Properly Identify “Unusual” Hepatitis C Virus Subtypes Resistant to Direct-Acting Antiviral Drugs in The Gambia 病毒学工具未能正确识别冈比亚对直接抗病毒药物耐药的“罕见”丙型肝炎病毒亚型 Erwan Vo-Quang and others The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 216–220, https://doi.org/10.1093/infdis/jiaf378 Major Articles and Brief Reports（主要论著和简短报告） Public Health（公共健康） 28 A Framework for Assessing the Opportunity for Advanced Research, Development, and Regulatory Approval of Medical Countermeasures: A Component of BARDA's Emerging Infectious Diseases Strategy 评估医疗对策先进研究、开发和监管批准机会的框架：生物医学高级研究与发展管理局（BARDA）新兴传染病战略的组成部分 Richard C White and others The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e1–e10, https://doi.org/10.1093/infdis/jiaf486 Bacterial Disease Pathogenesis（细菌性疾病发病机制） 29 Prevalence of Candidate Vaccine Targets and Genomic Features of Pediatric Invasive Streptococcus Agalactiae in Japan 日本儿科侵袭性无乳链球菌候选疫苗靶点的流行率及基因组特征 Masashi Kasai and others The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e11–e21, https://doi.org/10.1093/infdis/jiaf491 30 Daptomycin-Loaded Nanocarriers Facilitate Synergistic Killing of Methicillin-Resistant Staphylococcus aureus via Lipid-Mediated Interactions and Targeting 载达托霉素纳米载体通过脂质介导的相互作用和靶向作用促进对耐甲氧西林金黄色葡萄球菌的协同杀伤 Jhih-Hang Jiang and others The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e22–e33, https://doi.org/10.1093/infdis/jiaf492 31 Comparing Respiratory Illness Surveillance Case Definitions to Detect Bordetella pertussis in Children Aged <5 Years With Respiratory Illness in South Africa, 2017–2023 Kate Bishop and others 比较呼吸道疾病监测病例定义以检测2017 - 2023年南非5岁以下呼吸道疾病患儿中的百日咳博德特氏菌 The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e34–e43, https://doi.org/10.1093/infdis/jiaf501 32 Insights on Recurrent and Sequential Clostridioides difficile Infections From Genomic Surveillance in Minnesota, USA, 2019–2021 2019 - 2021年美国明尼苏达州基因组监测对复发性及序贯性艰难梭菌感染的见解 Daniel Evans and others The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e44–e54, https://doi.org/10.1093/infdis/jiaf505 33 Single-Cell Transcriptome Profiling Reveals the Immune Dysregulation Characteristics of Mice Infected With Brucella abortus 单细胞转录组分析揭示感染牛布鲁氏菌小鼠的免疫失调特征 Guangzhi Zhang and others The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e55–e66, https://doi.org/10.1093/infdis/jiaf522 34 Culture and Adaptation of Pseudomonas aeruginosa During Early Infection in Children With Cystic Fibrosis 囊性纤维化患儿早期感染期间铜绿假单胞菌的培养与适应 Sumitra D Mitra and others The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e67–e76, https://doi.org/10.1093/infdis/jiaf527 Viral Disease Pathogenesis（病毒性疾病发病机制） 35 Hyperendemicity of Rift Valley Fever in Southwestern Uganda Associated With the Rapidly Evolving Lineage C Viruses 乌干达西南部裂谷热高度流行与快速进化的C谱系病毒相关 Barnabas Bakamutumaho and others The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e77–e88, https://doi.org/10.1093/infdis/jiaf417 36 Relative Effectiveness of High-Dose Versus Standard-Dose Influenza Vaccination Against Hospitalizations and Deaths According to Frailty Score: A Post Hoc Analysis of the DANFLU-1 Randomized Trial 根据衰弱评分比较高剂量与标准剂量流感疫苗对住院和死亡的相对有效性：DANFLU - 1随机试验的事后分析 Caroline Espersen and others The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e89–e98, https://doi.org/10.1093/infdis/jiaf420 37 Emergence of Two New Lineages of the Cosmopolitan Dengue Virus Serotype 2 in Yunnan, China, 2024 2024年中国云南出现两种新的全球流行性登革热病毒2型谱系 Man Li and others The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e99–e108, https://doi.org/10.1093/infdis/jiaf422 38 Cerebrospinal Fluid Immune Cell Alterations in Women With Neuropsychiatric Long COVID 神经精神性新冠长期症状女性患者脑脊液免疫细胞改变 Benjamin Orlinick and others The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e109–e117, https://doi.org/10.1093/infdis/jiaf468 39 The Role of Enoxaparin in Influenza Virus Infections and its Therapeutic Implications 依诺肝素在流感病毒感染中的作用及其治疗意义 Marta Bermejo-Jambrina and others The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e118–e131, https://doi.org/10.1093/infdis/jiaf470 40 Monkeypox Virus Shedding Despite Tecovirimat Treatment in a Cohort in Toronto, Canada 加拿大多伦多一队列中接受特考韦瑞治疗后猴痘病毒仍排出的情况 Jacklyn R Hurst and others The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e132–e139, https://doi.org/10.1093/infdis/jiaf471 41 Disentangling Temporal Trends of Clade Ib Monkeypox Virus Transmission in Burundi 厘清布隆迪Ib支系猴痘病毒传播的时间趋势 Shihui Jin and others The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e140–e144, https://doi.org/10.1093/infdis/jiaf475 42 Profiling Human Papillomavirus Lineage-Specific Capsid Antigenicity With Geographically Diverse Natural Infection Antibodies 利用地理多样性自然感染抗体剖析人乳头瘤病毒谱系特异性衣壳抗原性 Kavita Panwar and others The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e145–e150, https://doi.org/10.1093/infdis/jiaf502 43 Respiratory Virus Infections and Pulmonary Impairment After Allogeneic Hematopoietic Cell Transplantation 异基因造血细胞移植后呼吸道病毒感染与肺功能损害 Guang-Shing Cheng and others The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e151–e163, https://doi.org/10.1093/infdis/jiaf503 Antimicrobial Resistance (AMR)（抗菌药物耐药性） 44 Insights Into Global Antimicrobial Resistance Dynamics Through the Sequencing of Enteric Bacteria From US International Travelers 通过对美国国际旅行者肠道细菌测序洞察全球抗菌药物耐药性动态 Sushmita Sridhar and others The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e164–e173, https://doi.org/10.1093/infdis/jiaf469 45 The Burden of Surgical Site Infections With Pathogens Presumably Resistant to Perioperative Prophylaxis in Orthopedic Tumor Surgery: Secondary Analysis of the Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY) Trial 骨科肿瘤手术中疑似对围手术期预防用药耐药的手术部位感染负担：肿瘤手术预防性抗生素方案（PARITY）试验的二次分析 Sabine Kuster and others The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e174–e182, https://doi.org/10.1093/infdis/jiaf513 46 Foreign Combatants Wounded in Ukraine Colonized by Extensively Drug-Resistant Organisms: A Potential Source of Global Dissemination 在乌克兰受伤的外国战斗人员被广泛耐药菌定植：全球传播的潜在来源 Patrick Mc Gann and others The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e183–e191, https://doi.org/10.1093/infdis/jiaf538 HIV/AIDs（HIV/艾滋病） 47 Long-Acting Antiretroviral Therapy for Breastfeeding Women With HIV Experiencing Barriers to Adherence in Zimbabwe: Modeling Clinical Impact and Cost-effectiveness 针对津巴布韦存在依从性障碍的感染HIV的哺乳期妇女采用长效抗逆转录病毒疗法的临床影响和成本效益建模 Sujata E Tewari and others The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e192–e202, https://doi.org/10.1093/infdis/jiaf521 48 Resistance Analyses of Lenacapavir, Emtricitabine/Tenofovir Alafenamide and Emtricitabine/Tenofovir Disoproxil Fumarate in the PURPOSE 1 and 2 Studies PURPOSE 1和2研究中来那卡帕韦、恩曲他滨/丙酚替诺福韦和恩曲他滨/富马酸替诺福韦二吡呋酯的耐药性分析 Stephanie Cox and others The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e203–e211, https://doi.org/10.1093/infdis/jiaf533 49 Resistance Analysis of Low-Level Virologic Rebound During HIV-1 Treatment With Lenacapavir and Broadly Neutralizing Antibodies Teropavimab and Zinlirvimab 使用来那卡帕韦和广谱中和抗体特罗帕维单抗及津利瑞单抗治疗HIV - 1期间低水平病毒学反弹的耐药性分析 Lisa Selzer and others The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e212–e220, https://doi.org/10.1093/infdis/jiaf559 50 IL-4 Correlates With Bone Mineral Density in Men, and IL-4 Depletion May Drive Bone Loss in Men With HIV 白细胞介素 - 4与男性骨矿物质密度相关，白细胞介素 - 4耗竭可能导致感染HIV男性骨丢失 Ighovwerha Ofotokun and others The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e221–e229, https://doi.org/10.1093/infdis/jiaf570 Correspondence（读者来信） 51 External Validation of Pediatric Pneumonia and Bronchiolitis Risk Scores to Predict Mortality in Children Hospitalized in Kenya: A Retrospective Cohort Study 儿科肺炎和毛细支气管炎风险评分在预测肯尼亚住院儿童死亡率方面的外部验证：一项回顾性队列研究 Becky Gordon and others The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e230–e238, https://doi.org/10.1093/infdis/jiaf377 52 Seroprevalence of Antibodies Against Legionella Species in Northeastern Australian Blood Donors, 2016 and 2023 2016年和2023年澳大利亚东北部献血者中针对军团菌属抗体的血清阳性率 Juniper Lethbridge and others The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e239–e249, https://doi.org/10.1093/infdis/jiaf407 53 Diagnostic Performance and Kinetics of Hepatitis E Viral RNA and IgM Antibody Test Positivity in a Genotype 1 Outbreak in South Sudan 南苏丹1型基因型戊型肝炎病毒暴发期间戊型肝炎病毒RNA和IgM抗体检测阳性的诊断性能和动力学 Aybüke Koyuncu and others The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e250–e258, https://doi.org/10.1093/infdis/jiaf436 54 Leptospirosis Prevalence and Risk Factors Among Patients Presenting With Fever to 4 Healthcare Sites in Sub-Saharan Africa and South East Asia: An International Multisite Observational and Nested Case–Control Study 撒哈拉以南非洲和东南亚4个医疗站点发热患者中钩端螺旋体病的流行率和危险因素：一项国际多站点观察性和嵌套病例对照研究 John A Crump and others The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e259–e270, https://doi.org/10.1093/infdis/jiaf464 55 Refined Transgenic Mouse Models Which Recapitulate the Natural Features of Chronic Wasting Disease With Rapid Prion Disease Onsets 改良转基因小鼠模型可快速引发朊病毒病并重现慢性消耗性疾病的自然特征 Joseph P DeFranco and others The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e271–e276, https://doi.org/10.1093/infdis/jiaf529 Correction（更正） 56 Correction to: Monocytes and Macrophages, Targets of Severe Acute Respiratory Syndrome Coronavirus 2: The Clue for Coronavirus Disease 2019 Immunoparalysis 更正：单核细胞和巨噬细胞——严重急性呼吸综合征冠状病毒2的靶点：2019冠状病毒病免疫麻痹的线索 The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Page e277, https://doi.org/10.1093/infdis/jiaf622 Editor's Note（编者按） 57 Editor's Note: Bartonella quintana Bacteremia and Overproduction of Interleukin-10: Model of Bacterial Persistence in Homeless People 编者按：五日热巴尔通体菌血症和白细胞介素 - 10过度产生：无家可归者细菌持续存在的模型 The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Page e278, https://doi.org/10.1093/infdis/jiaf623 58 Editor's Note: Oral Ivermectin in the Treatment of Body Lice 编者按：口服伊维菌素治疗体虱 The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Page e279, https://doi.org/10.1093/infdis/jiaf627 JID 2025 Reviewer Recognition（《传染病杂志》2025年审稿人认证） 59 2025 JID Reviewer Recognition List 2025年《传染病杂志》审稿人认证名单 The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e280–e286, https://doi.org/10.1093/infdis/jiag015 The Journal of Infectious Diseases. Volume 233 Issue 2 传染病杂志 233卷 2期 https://academic.oup.com/jid/issue/ Editorials（社论） 1 2025 Content Collections from the IDSA Journals 2025年美国感染病学会（IDSA）期刊内容合集 Roger Bedimo and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 221–222, https://doi.org/10.1093/infdis/jiag041 2 “Fostemsavir: More Than Meets the Eye” “福替沙韦：不止于表面所见” Siddharth Kogilwaimath and Netanya S Utay The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 223–226, https://doi.org/10.1093/infdis/jiaf462 3 On-Demand Dosing of HIV Preexposure Prophylaxis for Women: Has Their Time Finally Come? 女性按需服用艾滋病病毒暴露前预防药物：时机是否已到？ Susan P Buchbinder and Peter L Anderson The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 227–229, https://doi.org/10.1093/infdis/jiaf507 Invited Perspective（特邀观点） 4 The Changing Paradigm in Infectious Diseases—Host-Directed Medicine: Implications for the Next Generation of ID Physicians 感染性疾病领域的范式转变——宿主导向疗法：对下一代传染病医师的影响 Jatin M Vyas and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 230–234, https://doi.org/10.1093/infdis/jiaf497 Invited ID Translational Science Update（特邀传染病转化医学更新） 5 Targeting Tryptophan Metabolism for Tuberculosis Biomarkers and Host-Directed Therapy 以色氨酸代谢为靶点，开发结核病生物标志物和宿主导向疗法 Jeffrey M Collins and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 235–243, https://doi.org/10.1093/infdis/jiaf510 6 Clinical Commentary on: Targeting Tryptophan Metabolism for Tuberculosis Biomarkers and Host-Directed Therapy 关于“以色氨酸代谢为靶点，开发结核病生物标志物和宿主导向疗法”的临床评论 Joel D Ernst The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 244–246, https://doi.org/10.1093/infdis/jiaf624 Major Articles and Brief Reports（主要论著与简要报告） HIV/AIDs（人类免疫缺陷病毒/艾滋病） 7 Fostemsavir Decreases the Levels of Anti-gp120 CD4-Induced Antibodies in Heavily Treatment-Experienced People With HIV 福替沙韦可降低经治重度HIV感染者体内抗gp120 CD4诱导抗体的水平 Mehdi Benlarbi and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 247–256, https://doi.org/10.1093/infdis/jiaf461 8 Optimizing On-Demand Tenofovir Disoproxil Fumarate/Emtricitabine Dosing in Women for HIV Prevention 优化女性按需服用富马酸替诺福韦二吡呋酯/恩曲他滨预防HIV感染的剂量 Nathan Engel and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 257–260, https://doi.org/10.1093/infdis/jiaf459 9 Cabotegravir and Rilpivirine Concentrations and HIV-1 RNA Suppression in Genital Fluids and Rectum in People with HIV on Long-Acting Intramuscular Cabotegravir Plus Rilpivirine Antiretroviral Therapy 接受长效肌肉注射卡博特韦加利匹韦林抗逆转录病毒治疗的HIV感染者生殖道分泌物和直肠中的卡博特韦和利匹韦林浓度及HIV-1 RNA抑制情况 Analuz Fernández and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 261–266, https://doi.org/10.1093/infdis/jiaf551 10 Elimination of Human Immunodeficiency Virus Reservoirs Harboring Intact Proviruses 清除携带完整前病毒的HIV储存库 Min Li and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 267–277, https://doi.org/10.1093/infdis/jiaf373 11 Vaccination Against Pathogens Targeting Cell-Derived Cryptic Antigens 针对细胞来源的隐蔽抗原的病原体疫苗接种 Emily S Clark and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 278–286, https://doi.org/10.1093/infdis/jiaf593 12 NAT2 Polymorphisms and Antituberculosis-Induced Hepatotoxicity in Thai People Living With HIV: Insights From a Pharmacogenetic–Pharmacokinetic Cohort Study 泰国HIV感染者NAT2基因多态性与抗结核治疗所致肝毒性的关系：一项药物基因组学-药代动力学队列研究的见解 Napon Hiranburana and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 287–297, https://doi.org/10.1093/infdis/jiaf511 Bacterial Disease Pathogenesis（细菌性疾病发病机制） 13 Interplay between Tetanus, Diphtheria, Acellular Pertussis Vaccination in Pregnancy and Infant Pneumococcal Vaccination in Shaping Infant Pneumococcal Vaccine Serotype Carriage 孕期接种破伤风、白喉、无细胞百日咳疫苗与婴儿接种肺炎球菌疫苗对婴儿肺炎球菌疫苗血清型携带的影响 Eline Van den Bosch and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 298–306, https://doi.org/10.1093/infdis/jiaf458 14 Role of Activin A–Mediated KAT8 Expression in Regulating Ferroptosis During Mycobacterium tuberculosis Infection Activin A介导的KAT8表达在结核分枝杆菌感染中调节铁死亡的作用 Bijewar Ashish Satish and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 307–318, https://doi.org/10.1093/infdis/jiaf482 15 Phospholipid Transporter MlaFEDCB Regulates Klebsiella pneumoniae Virulence by Modulating Fimbriae Synthesis and Stress-adaptive Growth 磷脂转运蛋白MlaFEDCB通过调节菌毛合成和应激适应性生长来调控肺炎克雷伯菌的毒力 Xiaoyu Zhao and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 319–327, https://doi.org/10.1093/infdis/jiaf517 16 Novel KPC-2 Plasmid in a Clinical Salmonella Rissen Selected by Antibiotic Pressure 抗生素压力下临床沙门氏菌里森氏菌中新型KPC-2质粒的出现 María Aznar Fernández and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 328–333, https://doi.org/10.1093/infdis/jiaf536 Viral Disease Pathogenesis（病毒性疾病发病机制） 17 Respiratory Syncytial Virus Fusion Protein Epitope-Specific Antibodies and Neutralizing Activities Against Various Respiratory Syncytial Virus Strains 呼吸道合胞病毒融合蛋白表位特异性抗体对多种呼吸道合胞病毒株的中和活性 Hisao Okabe and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 334–341, https://doi.org/10.1093/infdis/jiaf375 18 Clinical and Environmental Surveillance of Poliovirus Type 2 Outbreak Using a Novel Specific Real-time Quantitative Polymerase Chain Reaction Assay, Israel, 2022–2023 2022-2023年以色列利用新型特异性实时定量聚合酶链反应检测法对2型脊髓灰质炎病毒疫情进行临床和环境监测 Itay Bar-Or and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 342–350, https://doi.org/10.1093/infdis/jiaf387 19 Robust COVID-19 Mortality Risk Assessment: Validation of a Two-Step Algorithm From the National COVID Cohort Collaborative 稳健的COVID-19死亡风险评估：国家COVID队列协作组织的两步算法验证 Bingnan Li and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 351–362, https://doi.org/10.1093/infdis/jiaf393 20 Histone Deacetylase 6 Regulates α-Tubulin to Inhibit the Stimulator of Interferon Genes/NLR Family Pyrin Domain-Containing 3-Mediated Microglial Pyroptosis Induced by Herpes Simplex Virus Type 1 Infection 组蛋白去乙酰化酶6调节α-微管蛋白，抑制1型单纯疱疹病毒感染诱导的干扰素基因刺激因子/NLR家族含吡啶结构域蛋白3介导的小胶质细胞焦亡 Qiongzhen Zeng and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 363–374, https://doi.org/10.1093/infdis/jiaf404 Parasites（寄生虫） 21 Schistosome Infection is Associated With High-Risk Human Papillomavirus Persistence, Together With Altered Cervicovaginal Microbiota 血吸虫感染与高危型人乳头瘤病毒持续感染及宫颈阴道微生物群改变相关 Crispin Mukerebe and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 375–380, https://doi.org/10.1093/infdis/jiaf447 22 The Source-Sink Dynamics of Plasmodium vivax May Undermine Malaria Elimination Efforts in the Amazon: An Epidemiological and Population Genomic Study 恶性疟原虫的源-汇动态可能破坏亚马逊地区疟疾消除工作：一项流行病学和群体基因组学研究 Nathalia Rammé M de Albuquerque and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 381–390, https://doi.org/10.1093/infdis/jiaf457 23 Seasonal Variation and Interspecies Dynamics Among Plasmodium falciparum and ovale Species in Bagamoyo, Tanzania 坦桑尼亚巴加莫约地区恶性疟原虫和卵形疟原虫的季节性变化及种间动态 Kelly Carey-Ewend and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 391–400, https://doi.org/10.1093/infdis/jiaf498 24 Genome Sequencing of Leishmania tropica in Tissues of Moroccan Patients Reveals Microfocal Transmission Underlain by (Pseudo)Clonal and Sexual Reproduction 摩洛哥患者组织中利什曼原虫热带种的基因组测序揭示了（假）克隆和有性繁殖导致的微灶性传播 Othmane Daoui and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 401–410, https://doi.org/10.1093/infdis/jiaf485 25 Trichomonas vaginalis Among Cisgender Women Taking Doxycycline Postexposure Prophylaxis 顺性别女性服用多西环素暴露后预防药物期间的阴道毛滴虫感染情况 Fredericka Albertina Sesay and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 411–415, https://doi.org/10.1093/infdis/jiaf519 26 A BEACON for Novel Disease Threats: Leveraging Artificial Intelligence for Informal Event-Based Outbreak Surveillance 应对新型疾病威胁的“灯塔”：利用人工智能进行非正式事件疫情监测 Nahid Bhadelia and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e287–e289, https://doi.org/10.1093/infdis/jiaf642 Major Articles and Brief Reports（主要论著与简要报告） Bacterial Disease Pathogenesis（细菌性疾病发病机制） 27 Chlamydia trachomatis-specific T Cell Immunity Reflects Widespread Exposure in South African Adolescents and Young Women 沙眼衣原体特异性T细胞免疫反映南非青少年和年轻女性广泛暴露情况 Rubina Bunjun and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e290–e300, https://doi.org/10.1093/infdis/jiaf595 28 Serum IgG1 and IgG3 Antibodies to Chlamydia trachomatis Pgp3 and Hsp60 in Men of Subfertile Couples 不育夫妇男性体内针对沙眼衣原体Pgp3和Hsp60的血清IgG1和IgG3抗体 Tiina Holster and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e301–e310, https://doi.org/10.1093/infdis/jiaf535 29 Publicly Available Neisseria Gonorrhoeae Genomes Predominantly Represent In Vitro-Derived Nonpiliated Variants 公开可用的淋病奈瑟菌基因组主要代表体外衍生的非菌毛变异体 Iryna Boiko and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e311–e321, https://doi.org/10.1093/infdis/jiaf557 30 Signal Transducers and Activators of Transcription 1 (STAT1), STAT2, and T Cells Mediate Interferon-Dependent Protection Against Neurobrucellosis 信号转导和转录激活因子1（STAT1）、STAT2和T细胞介导干扰素依赖性抗神经布鲁氏菌病的保护作用 Charles R Moley and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e322–e331, https://doi.org/10.1093/infdis/jiaf565 31 [18F]Fluorodeoxyglucose Positron Emission Tomography for Diagnosis and Monitoring of Acute Staphylococcus aureus Vascular Graft Infection in a Rat Model [18F]氟脱氧葡萄糖正电子发射断层扫描在诊断和监测大鼠急性金黄色葡萄球菌血管移植物感染中的应用 Emma Faddy and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e332–e341, https://doi.org/10.1093/infdis/jiaf594 32 Safety and Immunogenicity of a Klebsiella pneumoniae Tetravalent Bioconjugate Vaccine (Kleb4V) Administered to Healthy Adults: A First-in-Human Phase I/II Randomized and Controlled Study 健康成年人接种肺炎克雷伯菌四价生物结合疫苗（Kleb4V）的安全性和免疫原性：一项首次人体I/II期随机对照研究 C Alaimo and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e342–e351, https://doi.org/10.1093/infdis/jiaf600 COVID-2019 Disease Pathogenesis（新冠肺炎发病机制） 33 Prevalence of Symptoms Associated With Long COVID Among Adolescents in the United States, Summer 2022 2022年夏季美国青少年中与新冠长期症状相关症状的流行情况 Deja L Edwards and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e352–e362, https://doi.org/10.1093/infdis/jiaf454 34 COVID-19 Vaccine Effectiveness in Patients With Hematologic Malignancies: A Nationwide Cohort Study 血液系统恶性肿瘤患者中COVID-19疫苗的有效性：一项全国性队列研究 Quincy Hofsink and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e363–e372, https://doi.org/10.1093/infdis/jiaf523 35 Safety and Immunogenicity of a Severe Acute Respiratory Syndrome Coronavirus 2 Spike Subunit Vaccine Stabilized in the Prefusion Conformation by a Second-Generation Molecular Clamp and Evaluated in Adults Aged 18–55 Years: A Randomized, Double-Blind, Active Comparator, Phase I Trial 一种由第二代分子夹稳定在融合前构象的严重急性呼吸综合征冠状病毒2型刺突亚单位疫苗在18 - 55岁成年人中的安全性和免疫原性：一项随机、双盲、活性对照、I期试验 Keith J Chappell and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e373–e382, https://doi.org/10.1093/infdis/jiaf568 Viral Disease Pathogenesis（病毒性疾病发病机制） 36 Durability of the Mumps Antibody Response After the Third Dose of MMR Vaccine 接种第三剂麻腮风疫苗后腮腺炎抗体反应的持久性 Sun B Sowers and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e383–e391, https://doi.org/10.1093/infdis/jiaf520 37 Immune Responses to BK Virus in Renal Transplant Recipients Receiving Intravenous Immunoglobulin Treatment 接受静脉注射免疫球蛋白治疗的肾移植受者对BK病毒的免疫反应 Kevin D He and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e392–e403, https://doi.org/10.1093/infdis/jiaf525 38 Epstein-Barr Virus Antibody Response Patterns in Endemic and Nonendemic Cases of Nasopharyngeal Carcinoma 鼻咽癌流行区和非流行区病例中EB病毒抗体反应模式 Ilona Argirion and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e404–e408, https://doi.org/10.1093/infdis/jiaf526 39 Genomic Surveillance and Antigenic Characterization of Respiratory Syncytial Virus (RSV) in Spain During the 2023-2024 Season of Nirsevimab Administration 2023 - 2024年西班牙尼塞韦单抗给药季节呼吸道合胞病毒（RSV）的基因组监测和抗原特征分析 María Iglesias-Caballero and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e409–e418, https://doi.org/10.1093/infdis/jiaf530 40 Establishment of a Cynomolgus Macaque Model for Human Adenovirus Type 55–Induced Respiratory Disease 建立食蟹猴模型用于研究人类55型腺病毒引起的呼吸道疾病 Sang Hwan Seo and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e419–e429, https://doi.org/10.1093/infdis/jiaf542 41 Adenovirus 40 and 41 Antibodies Associated With Protection From Infection in a Bangladeshi Birth Cohort 孟加拉国出生队列中与预防腺病毒40型和41型感染相关的抗体 Jennifer Hendrick and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e430–e440, https://doi.org/10.1093/infdis/jiaf558 42 Natural History of Nipah Virus in Hamsters: Strain, Route, and Sex-Associated Variability Characterized Using Large Datasets to Inform Pre-Clinical Study Design 利用大型数据集研究仓鼠中尼帕病毒的自然史：不同毒株、感染途径和性别的变异性，为临床前研究设计提供依据 Katherine A Davies and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e441–e453, https://doi.org/10.1093/infdis/jiaf549 43 Estimation of Prevention-Effective CAB-LA Concentrations Among Men Who Have Sex With Men (MSM) and Transgender Women (TGW) in HPTN 083 在HPTN 083研究中估算男男性行为者（MSM）和跨性别女性（TGW）中预防有效的长效卡博特韦浓度 Brett Hanscom and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e454–e461, https://doi.org/10.1093/infdis/jiaf561 44 Assessment of Concordant Human Papillomavirus Infection With 9-Valent Vaccine Types Across Anogenital Sites in Young Men 评估年轻男性肛门生殖器部位九价疫苗类型人乳头瘤病毒的一致感染情况 Cara J Broshkevitch and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e462–e470, https://doi.org/10.1093/infdis/jiaf564 Parasites（寄生虫） 45 From Skin to Sequence: Pan-species Detection and Speciation of Leishmania 从皮肤到序列：利什曼原虫的全物种检测与鉴定 Nicholas R Duncan and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e471–e480, https://doi.org/10.1093/infdis/jiaf345 46 A Human Monoclonal Antibody Targeting α-Gal Ameliorates Experimental Cutaneous Leishmaniasis 一种靶向α-半乳糖苷的人单克隆抗体可改善实验性皮肤利什曼病 Hyeseon Cho and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e481–e490, https://doi.org/10.1093/infdis/jiaf350 47 Artemisinin Partial Resistance Mutations in Zanzibar and Tanzania Suggest Regional Spread and African Origins, 2023 2023年桑给巴尔和坦桑尼亚的青蒿素部分耐药突变提示区域传播和非洲起源 Sean V Connelly and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e491–e495, https://doi.org/10.1093/infdis/jiaf431 48 A Multivalent Peptide Vaccine Against Malaria, Targeting Plasmodium Circumsporozoite Protein and Mosquito AgTRIO 一种针对疟疾的多价肽疫苗，靶向疟原虫环子孢子蛋白和蚊子AgTRIO Yu-Min Chuang and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e496–e500, https://doi.org/10.1093/infdis/jiaf432 49 Spontaneous Clearance of Polymerase Chain Reaction–Positive Plasmodium vivax Parasitemia in Northwestern Thailand: An Epidemiological Perspective 泰国西北部聚合酶链反应阳性的恶性疟原虫血症的自发清除：流行病学视角 Pyae Linn Aung and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e501–e509, https://doi.org/10.1093/infdis/jiaf473 50 Gene Editing of a Carcinogenic Liver Fluke Tetraspanin Impairs Parasite Surface Biogenesis and Extracellular Vesicle Uptake by Human Host Cells 对致癌性肝吸虫四跨膜蛋白进行基因编辑，可损害寄生虫表面生物合成以及人宿主细胞对细胞外囊泡的摄取 Sujittra Chaiyadet and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e510–e520, https://doi.org/10.1093/infdis/jiaf466 Antimicrobial Resistance (AMR)（抗菌药物耐药性） 51 Ampicillin/Sulbactam in Combination with Ceftazidime/Avibactam Against Metallo-β-Lactamase-Producing Carbapenem-Resistant Acinetobacter baumannii: A Genomics-Informed Mechanism-based model 氨苄西林/舒巴坦联合头孢他啶/阿维巴坦治疗产金属β-内酰胺酶的碳青霉烯耐药鲍曼不动杆菌：基于基因组学的机制模型 Bhavatharini Arun and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e521–e533, https://doi.org/10.1093/infdis/jiaf567 52 CRISPR-Cas–associated SCCmec Variants in Methicillin-resistant Staphylococcus aureus Evade Rapid Diagnostic Detection 耐甲氧西林金黄色葡萄球菌中与CRISPR-Cas相关的SCCmec变异体可逃避快速诊断检测 Magdalena Podkowik and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e534–e540, https://doi.org/10.1093/infdis/jiaf575 53 Evaluation of Phenotypic and Genotypic Susceptibility Testing Methods for Newer β-lactam/β-lactamase Inhibitor Combinations in Multidrug Resistant Pseudomonas aeruginosa 评估多药耐药铜绿假单胞菌中新型β-内酰胺/β-内酰胺酶抑制剂组合的表型和基因型敏感性检测方法 Clayton W Hall and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e541–e549, https://doi.org/10.1093/infdis/jiaf585 Fungi（真菌） 54 Adrenal Corticosteroids and Increased Intracranial Pressure in Nonimmunocompromised Patients With Cryptococcal Meningitis 非免疫抑制患者隐球菌性脑膜炎的肾上腺皮质类固醇与颅内压升高 John E Bennett and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e550–e552, https://doi.org/10.1093/infdis/jiaf490 55 Corticosteroid Therapy and Long-Term Outcomes of Post-Infectious Inflammatory Syndrome in Non-HIV Immunosuppressed Cryptococcal Meningitis: A Multicenter Case Series 非HIV免疫抑制隐球菌性脑膜炎患者感染后炎性综合征的皮质类固醇治疗和长期预后：一项多中心病例系列研究 Yuya Ito and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e553–e560, https://doi.org/10.1093/infdis/jiaf620 56 Cerebral Venous Thrombosis in Previously Healthy Patients with Cryptococcal Meningitis 既往健康患者隐球菌性脑膜炎并发脑静脉血栓形成 Seher H Anjum and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e561–e569, https://doi.org/10.1093/infdis/jiaf653 57 The Gut as a Source of Infection for Fungal Pathogens: Increased Fecal Candida albicans Precedes Onset of Candida Late-Onset Sepsis in Very Preterm Infants 肠道作为真菌病原体感染的来源：极早产儿白色念珠菌粪便含量增加早于迟发性念珠菌脓毒症发作 Rimke R de Kroon and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e570–e581, https://doi.org/10.1093/infdis/jiaf524 Correspondence（读者来信） 58 Accurate Measurement of Viral Clearance in Early-Phase Antiviral Studies in Coronavirus Disease 2019 2019冠状病毒病早期抗病毒研究中病毒清除的准确测量 Phrutsamon Wongnak and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e582–e584, https://doi.org/10.1093/infdis/jiaf442 59 Evaluating Viral Load Sampling Schemes and Swabbing Methods for Optimal Surrogacy 评估病毒载量采样方案和拭子采集方法以实现最佳替代指标 Allyson Mateja and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e585–e586, https://doi.org/10.1093/infdis/jiaf443 60 Effect of 5FU on paracoccidioidomycosis 5-氟尿嘧啶对副球孢子菌病的影响 David A Stevens The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Page e587, https://doi.org/10.1093/infdis/jiaf508 61 Response to D. Stevens Letter 对D. Stevens信件的回复 Nycolas Preite The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Page e588, https://doi.org/10.1093/infdis/jiaf509 62 Evaluating Clinical Impacts of Accessory Genome Elements: Escherichia coli Type III Secretion System 2 in Escherichia coli and Beyond! 评估附属基因组元件的临床影响：大肠杆菌III型分泌系统2在大肠杆菌及其他细菌中的作用！ Abi Manesh and others The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e589–e590, https://doi.org/10.1093/infdis/jiaf515 63 Alarming Prevalence of Gonococcal Ceftriaxone Resistance in Vietnam—Role of Periodic Presumptive Antimicrobials? 越南淋球菌头孢曲松耐药性的惊人流行率——定期假定使用抗菌药物的作用？ Chris Kenyon The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e591–e592, https://doi.org/10.1093/infdis/jiaf553 The Journal of Infectious Diseases. Volume 233 Issue 3 传染病杂志 233卷 3期 https://academic.oup.com/jid/issue/ Editorial（社论） 1 Mechanistic Insights Into Increased Vulnerability to Respiratory Infections in HIV-Exposed Uninfected Infants 未感染婴儿HIV暴露对呼吸道感染易感性增加的机制研究 Cheryl Cohen and Penny Moore The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 417–419, https://doi.org/10.1093/infdis/jiaf494 Viewpoint（观点） 2 Every Body Has Value: Ending Discriminatory Restrictions on Anatomical Donations 每例身体都有其价值：终止对解剖捐赠的歧视性限制 Sara Gianella and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 420–422, https://doi.org/10.1093/infdis/jiaf413 ID Translational Science Update（传染病转化医学最新进展） 3 Syphilis Transmission: Contagion of Bodies and Words 梅毒传播：身体与言语的双重传播 Maurizio Bifulco and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 423–427, https://doi.org/10.1093/infdis/jiaf576 Major Articles and Brief Reports（主要论著与简要报告） HIV/AIDs（人类免疫缺陷病毒/艾滋病） 4 Maternal Inflammation Likely Drives Impaired Immune Responses to Respiratory Syncytial Virus in HIV-Exposed Uninfected Infants 母体炎症可能是导致HIV暴露于未感染婴儿对呼吸道合胞病毒免疫应答受损的原因 Christiana Smith and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 428–439, https://doi.org/10.1093/infdis/jiaf493 Bacterial Disease Pathogenesis（细菌性疾病发病机制） 5 Large Reductions in Invasive Pneumococcal Disease and Related Morbidities Among Children in New Zealand After Change From PCV10 to PCV13 新西兰儿童在从PCV10换用PCV13后，侵袭性肺炎球菌病及相关发病率大幅下降 Andrew Anglemyer and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 440–444, https://doi.org/10.1093/infdis/jiaf587 6 Lack of S100A8 Impairs Lung-Protective Immunity Against Streptococcus pneumoniae 缺乏S100A8会损害针对肺炎链球菌的肺部保护性免疫 Lena Ostermann and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 445–457, https://doi.org/10.1093/infdis/jiaf647 7 Microbial Dominance in Diabetic Foot Osteomyelitis Determined With Nanopore Sequencing Techniques Predicts Positive Response to Surgical Intervention 利用纳米孔测序技术确定糖尿病足骨髓炎中的微生物优势种，可预测对手术干预的积极反应 Brian M Schmidt and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 458–464, https://doi.org/10.1093/infdis/jiaf617 8 Characteristics and Antiadhesion Activity of Chicken Single-Chain Fragment Variable Antibodies Against Helicobacter pylori Adhesin A 针对幽门螺杆菌黏附素A的鸡单链抗体片段的特性及其抗黏附活性 Yanan Gong and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 465–474, https://doi.org/10.1093/infdis/jiaf550 9 Bartonella henselae Subverts Host Cell Apoptosis by Linking Intracellular NOD2 Sensing to an AREG/EGFR Autocrine Survival Loop 汉赛巴尔通体通过将细胞内NOD2感知与AREG/EGFR自分泌生存环联系起来，破坏宿主细胞凋亡 Jun He and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 475–484, https://doi.org/10.1093/infdis/jiaf566 Viral Disease Pathogenesis（病毒性疾病发病机制） 10 Influenza-associated Excess Mortality Associated With Influenza B in Hong Kong, 2014–2023 2014 - 2023年香港地区乙型流感相关的超额死亡率 Jessica Y Wong and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 485–492, https://doi.org/10.1093/infdis/jiaf414 11 Disparate Kinetics of Viable Virus Shedding in Immunocompromised Patients: SARS-CoV-2 Versus Influenza Virus—A Prospective Real-World Cohort Study 免疫功能低下患者中存活病毒脱落动力学差异：新冠病毒与流感病毒——一项前瞻性真实世界队列研究 So Yun Lim and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 493–497, https://doi.org/10.1093/infdis/jiaf479 12 Autoantibodies Against Type I Interferons are a Prominent Feature in SARS-CoV-2 Fatal Disease and Hospitalization 针对I型干扰素的自身抗体是严重急性呼吸综合征冠状病毒2型致命性和住院治疗的显著特征 Rebeca Linhares Abreu Netto and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 498–509, https://doi.org/10.1093/infdis/jiaf514 13 Genetic Landscape of a Cohort of Children With Varicella Zoster Virus Encephalitis, Cerebellitis, and Stroke 水痘带状疱疹病毒脑炎、小脑炎和中风患儿队列的遗传学特征 Franziska Winzig and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 510–520, https://doi.org/10.1093/infdis/jiaf448 14 The Diagnostic Value of Soluble Epstein-Barr Virus BZLF1 Protein in Posttransplant Lymphoproliferative Disease Among Solid Organ and Hematopoietic Cell Transplant Recipients 可溶性爱泼斯坦-巴尔病毒BZLF1蛋白在实体器官和造血细胞移植受者移植后淋巴增殖性疾病中的诊断价值 Neval Ete Wareham and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 521–527, https://doi.org/10.1093/infdis/jiaf477 15 Noninvasive Detection of Occult yet Significant Liver Pathology in Alanine Aminotransferase–Normal Chronic Hepatitis B: A Multicenter Study 丙氨酸氨基转移酶正常的慢性乙型肝炎患者中非侵入性检测隐匿却重要的肝脏病理：一项多中心研究 Xinjie Li and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 528–540, https://doi.org/10.1093/infdis/jiaf554 16 Mesenteric Ischemia and Bacterial Translocation Precipitate the Intoxication Phase of Yellow Fever 肠系膜缺血和细菌移位促使黄热病进入中毒阶段 Mateus V Thomazella and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 541–553, https://doi.org/10.1093/infdis/jiaf483 17 Essential Role of Clathrin and Lipid Rafts in pH-dependent Entry of Chandipura Virus: Independence From Caveolin Pathway 网格蛋白和脂质筏在Chandipura病毒pH依赖性进入过程中的重要作用：独立于小窝蛋白途径 Ritudhwaj Tiwari and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 554–559, https://doi.org/10.1093/infdis/jiaf446 Fungi（真菌） 18 Blood Cultures Contain Populations of Genetically Diverse Candida albicans Strains that May Differ in Echinocandin Tolerance and Fitness 血培养中含有遗传多样的白色念珠菌菌株群体，这些菌株在棘白菌素耐受性和适应性方面可能存在差异 Giuseppe Fleres and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 560–572, https://doi.org/10.1093/infdis/jiaf495 19 Interferon-gamma Production Defects Characterize Immune Responses in Patients With Chronic Pulmonary Aspergillosis 干扰素-γ产生缺陷是慢性肺曲霉病患者免疫应答的特征 Nico A F Janssen and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 573–582, https://doi.org/10.1093/infdis/jiaf596 20 Tumor Necrosis Factor Receptor–Associated Factor 1 Inhibits Macrophage Killing of Sporothrix schenckii by Enhancing Expression and Activity of Inducible Nitric Oxide Synthase 肿瘤坏死因子受体相关因子1通过增强诱导型一氧化氮合酶的表达和活性，抑制巨噬细胞对申克孢子丝菌的杀伤作用 Congcong He and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 583–593, https://doi.org/10.1093/infdis/jiaf646 Global Health（全球健康） 21 Rifampin Exposure in Pregnant and Nonpregnant Women With Tuberculosis in India 印度结核病孕妇和非孕妇的利福平暴露情况 Prakruti S Rao and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 594–597, https://doi.org/10.1093/infdis/jiaf467 22 Evaluating the Impact of Unadjusted Confounding and Study Design on Estimated Pathogen-attributable Diarrhea Incidence Among Children in the MAL-ED Cohort 评估未调整混杂因素和研究设计对MAL-ED队列中儿童病原体归因腹泻发病率估计的影响 Charlotte R Doran and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 598–606, https://doi.org/10.1093/infdis/jiaf531 23 Defining Severe Shigellosis in the Enterics for Global Health Study: A Comparison of Leading Diarrhea Severity Definitions Among Children With Shigella Diarrhea 全球肠道健康研究中对儿童严重志贺氏菌病的定义：志贺氏菌腹泻儿童中主要腹泻严重程度定义的比较 Olivia Lang Schultes and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 607–617, https://doi.org/10.1093/infdis/jiaf630 Editorial（社论） 24 Evidence for Neuroinvasive Lassa Virus Infection in Pediatric Patients: Initial Findings and Implications 儿科患者神经侵袭性拉沙病毒感染的证据：初步发现及启示 Andrew P Platt and Daniel S Chertow The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e593–e595, https://doi.org/10.1093/infdis/jiaf548 Perspectives（展望） 25 The Emerging Role of Immunothrombosis in the Control and Pathogenesis of Mycobacterium tuberculosis 免疫血栓形成在结核分枝杆菌控制和发病机制中的新兴作用 Seán Donohue and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e596–e599, https://doi.org/10.1093/infdis/jiaf415 ID Translational Science Update（传染病转化医学最新进展） 26 Whole-Exome Sequencing for the Identification of Genetic Factors Implicated in Severe Bacterial Infections: A Systematic Review 全外显子组测序用于鉴定与严重细菌感染相关的遗传因素：一项系统综述 Morgane Gélin and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e600–e610, https://doi.org/10.1093/infdis/jiag006 Major Articles and Brief Reports（主要论著与简要报告） Viral Disease Pathogenesis（病毒性疾病发病机制） 27 Presence of Lassa Virus RNA in Cerebrospinal Fluid Indicating Neuroinvasive Lassa Fever in Pediatric Patients From Edo State, Nigeria 尼日利亚埃多州儿科患者脑脊液中存在拉沙病毒RNA，表明存在神经侵袭性拉沙热 Hannah Caroline Sophie Müller and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e611–e620, https://doi.org/10.1093/infdis/jiaf547 28 Anti-HBs Immune Complex Levels: A Novel Marker of Hepatitis Flare Following Nucleos(t)ide Analog Withdrawal in HBeAg-negative Chronic Hepatitis B 抗-HBs免疫复合物水平：乙型肝炎e抗原阴性慢性乙型肝炎患者核苷（酸）类似物停药后肝炎发作的新型标志物 S J Hume and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e621–e629, https://doi.org/10.1093/infdis/jiaf569 29 Oral Microbiome Diversity Matters on Nucleos(t)ide Analogue Cessation in Chronic Hepatitis B 慢性乙型肝炎患者核苷（酸）类似物停药时口腔微生物组多样性的重要性 Mahin Ghorbani and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e630–e640, https://doi.org/10.1093/infdis/jiaf591 30 A Phase 1 Double-Blinded Trial to Evaluate Safety, Immunogenicity, and Dosing of Measles-Vectored Chikungunya Virus Vaccine (MV-CHIK) in Healthy Adults 一项评估健康成年人接种麻疹载体基孔肯雅病毒疫苗（MV-CHIK）的安全性、免疫原性和剂量的1期双盲试验 Patricia Winokur and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e641–e645, https://doi.org/10.1093/infdis/jiaf571 31 A Test-Negative Design for Immune Correlates Approximates a Traditional Exposure-Proximal Design but Requires Far Fewer Blood Samples 免疫相关因素的检验阴性设计近似于传统的暴露近端设计，但所需血液样本数量要少得多 Dean Follmann and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e646–e650, https://doi.org/10.1093/infdis/jiaf572 32 Comparison of Healthcare Resource Utilization and Disease Outcomes in Adults Hospitalized with Human Metapneumovirus and Respiratory Syncytial Virus 人偏肺病毒和呼吸道合胞病毒感染住院成人患者的医疗资源利用情况和疾病预后比较 Emily Rayens and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e651–e661, https://doi.org/10.1093/infdis/jiaf597 33 Avian Influenza Virus A(H5N1) Genotype D1.1 Is Better Adapted to Human Nasal and Airway Organoids Than Genotype B3.13 禽流感病毒A(H5N1) D1.1基因型比B3.13基因型更适应人体鼻腔和气道类器官 Xiaojuan Zhang and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e662–e666, https://doi.org/10.1093/infdis/jiaf598 34 The Impact of Corticosteroid Therapy on Patients With West Nile Virus: A Retrospective Cohort Study 皮质类固醇治疗对西尼罗河病毒患者的影响：一项回顾性队列研究 Itamar Poran and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e667–e673, https://doi.org/10.1093/infdis/jiaf601 35 Serological Survey in African Nonhuman Primate Species in Cameroon and the Democratic Republic of the Congo Reveals Low Overall Seroprevalence to Mpox Virus 对喀麦隆和刚果民主共和国非洲非人灵长类物种的血清学调查显示，猴痘病毒总体血清阳性率较低 Neraide Biai and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e674–e686, https://doi.org/10.1093/infdis/jiaf602 Bacterial Disease Pathogenesis（细菌性疾病发病机制） 36 Manufacture of Clostridioides difficile Spores for Experimental Infection of Human Volunteers 用于人体志愿者实验性感染的艰难梭菌孢子制备 Annefleur D O Hensen and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e687–e695, https://doi.org/10.1093/infdis/jiaf612 37 Digital Anorectal Examination to Self-detect Primary Syphilis: A Prospective Cohort Study 数字肛门直肠检查用于自我检测原发性梅毒：一项前瞻性队列研究 Julien Tran and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e696–e705, https://doi.org/10.1093/infdis/jiaf628 38 Higher Promoter Methylation of the Ubiquitin-Associated and SH3 Domain Containing A (UBASH3A) Gene Is Associated With T-Lymphocyte Ontogeny and Reduced Susceptibility to Early-Onset Sepsis 泛素相关和SH3结构域含A（UBASH3A）基因启动子高甲基化与T淋巴细胞发生及早发性脓毒症易感性降低相关 Ziyi Wang and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e706–e711, https://doi.org/10.1093/infdis/jiaf636 39 Efficacies of Sequenced Monotherapies of Mycobacterium avium Lung Infection in Mouse 小鼠肺鸟分枝杆菌感染序贯单一疗法的疗效 Ruth A Howe and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e712–e720, https://doi.org/10.1093/infdis/jiaf640 40 The Landscape and Regulatory Determinants of A-to-I RNA Editing in Escherichia coli and Pseudomonas aeruginosa Isolated From Patients With Urinary Tract and Ear Infections 从尿路感染和耳部感染患者中分离出的大肠杆菌和铜绿假单胞菌中A-to-I RNA编码的格局及调控决定因素 Eyal Elias and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e721–e730, https://doi.org/10.1093/infdis/jiaf645 Parasites（寄生虫） 41 Efficacy of Praziquantel for Treatment of Plasmodium falciparum Infection in Asymptomatic Gabonese Adults: A Double-Blind Placebo-Controlled Randomized Trial 双盲安慰剂对照随机试验评估吡喹酮治疗加蓬无症状成人恶性疟原虫感染的疗效 Johannes Mischlinger and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e731–e739, https://doi.org/10.1093/infdis/jiaf544 42 Chronic Malaria Is Associated With Trauma-related Splenic Rupture Requiring Splenectomy 慢性疟疾与创伤性脾破裂相关，需行脾切除术 Putu A I Shanti and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e740–e744, https://doi.org/10.1093/infdis/jiaf629 43 Extreme Genetic Diversity and Signatures of Balancing Selection in Plasmodium vivax Blood-Stage Antigens 间日疟原虫血液阶段抗原具有极高的遗传多样性和平衡选择的特征 Alison Paolo N Bareng and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e745–e755, https://doi.org/10.1093/infdis/jiaf539 44 How Duffy Blood Group (FY) Polymorphism and Age Modulate Vivax Malaria Risk at the Community Level: A Population-based Retrospective Cohort Study in the Amazon 社区层面杜菲血型（FY）多态性和年龄如何调节间日疟风险：亚马逊地区一项基于人群的回顾性队列研究 Carlos A Prete and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e756–e765, https://doi.org/10.1093/infdis/jiaf562 45 New Viability Assays for Acanthamoeba castellanii Trophozoites and Cysts Allow Rapid Assessment of Drug Activity 卡氏棘阿米巴滋养体和包囊新的活性检测方法可快速评估药物活性 Carrie A Flynn and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e766–e776, https://doi.org/10.1093/infdis/jiaf599 Global Health（全球健康） 46 Stunting Increases Influenza Virus Shedding Duration in Preschool/School-Aged Children 发育迟缓会增加学龄前/学龄儿童流感病毒脱落持续时间 Mia Q Zhu and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e777–e781, https://doi.org/10.1093/infdis/jiaf641 47 False-positive Malaria Rapid Diagnostic Tests are Prevalent Among Children Under 5 Years of Age in Uganda 乌干达5岁以下儿童疟疾快速诊断试验假阳性率较高 Caitlin A Cassidy and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e782–e790, https://doi.org/10.1093/infdis/jiaf604 48 Comparative Analysis of Flight Volume Effects on COVID-19 and Influenza Transmission Across Variable Control Intensities, 2019–2024 2019 - 2024年不同防控强度下航班量对新冠肺炎和流感传播影响的比较分析 Yanfang Xu and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e791–e801, https://doi.org/10.1093/infdis/jiaf545 49 High Seropositivity to rK39 and Capture of Leishmania-Infected Sand Flies in Bihar and Jharkhand Emphasize the Need for Post-Elimination Surveillance of Visceral Leishmaniasis in India 比哈尔邦和贾坎德邦rK39血清阳性率高且捕获到感染利什曼原虫的白蛉，强调印度内脏利什曼病消除后需加强监测 Eva Iniguez and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e802–e811, https://doi.org/10.1093/infdis/jiaf543 Microbiome（微生物组） 50 The Gut Microbiome and Butyrate Differentiate Clostridioides difficile Colonization and Infection in Children 肠道微生物组和丁酸盐可区分儿童艰难梭菌定植和感染 Maribeth R Nicholson and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e812–e822, https://doi.org/10.1093/infdis/jiaf631 51 Gut Microbiota Predicts the Risk of Future COVID-19 Hospitalization and Mortality: Insights From the Population-Based HELIUS Study 肠道微生物群可预测未来新冠肺炎住院和死亡风险：来自基于人群的HELIUS研究的见解 Robert F J Kullberg and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e823–e827, https://doi.org/10.1093/infdis/jiaf541 52 Douching Is Associated With Dysregulated Rectal Mucosal Immunity in Sexual Minority Men 灌洗与性少数男性直肠黏膜免疫失调相关 Courtney A Broedlow and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e828–e838, https://doi.org/10.1093/infdis/jiaf577 Correspondence（读者来信） 53 Effectiveness of 13-Valent Pneumococcal Conjugate Vaccine Against Pneumonia Hospitalization Among Medicare Beneficiaries Aged ≥65 in Long-Term Care 13价肺炎球菌结合疫苗对长期护理机构中≥65岁医疗保险受益人肺炎住院的预防效果 Wenwen Zhao and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Page e839, https://doi.org/10.1093/infdis/jiaf581 54 Letter to the Editor in Response to Zhao et al 致编辑的信（回应赵等人） Lindsay Zielinski and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e840–e841, https://doi.org/10.1093/infdis/jiaf582 55 Fishborne Trematodiases in the United States: A Blind Spot in U.S. Emerging Infectious Disease Preparedness 美国鱼源性吸虫病：美国新兴传染病防范中的盲点 Nathkapach K Rattanapitoon and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e842–e843, https://doi.org/10.1093/infdis/jiaf588 56 Comment on “A Review of Aedes aegypti Control in Peru: Approaches and Lessons Learned” 对“秘鲁伊蚊控制回顾：方法与经验教训”的评论 Carmen Thompson Perea and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e844–e845, https://doi.org/10.1093/infdis/jiaf589 57 Balancing Pharmacokinetic Targets and Lymphocyte Declines with Once-Monthly Oral Islatravir for PrEP 平衡药代动力学目标和淋巴细胞减少情况，每月一次口服艾斯拉特韦用于暴露前预防 Anxin Wen The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e846–e847, https://doi.org/10.1093/infdis/jiaf618 58 Polio-Free, Not Risk-Free: Wastewater as Early Warning 无脊髓灰质炎，但并非无风险：废水作为早期预警 Francesco Branda and others The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e848–e849, https://doi.org/10.1093/infdis/jiaf643 The Journal of Infectious Diseases. Volume 233 Issue Supplement_1 传染病杂志 233卷增刊1期 https://academic.oup.com/jid/issue/233/Supplement_1 SUPPLEMENT（增刊） Molecular Epidemiology of β-Lactam Resistance in Gram-negative Bacteria in China 中国革兰氏阴性菌β-内酰胺酶类抗生素耐药性的分子流行病学 Supplement Articles（增补论著） 1 Aztreonam-Avibactam Resistance Due to Synergistic Interplay of ampC-Related Mutations in Carbapenem-Resistant Enterobacter spp 碳青霉烯耐药肠杆菌属中因ampC相关突变的协同作用导致的氨曲南-阿维巴坦耐药 Yang Zeng and others The Journal of Infectious Diseases, Volume 233, Issue Supplement_1, 15 March 2026, Pages S1–S9, https://doi.org/10.1093/infdis/jiaf384 2 Molecular Mechanisms of β-Lactam Resistance and Its Contribution to Multidrug Resistance in Helicobacter pylori 幽门螺杆菌β-内酰胺酶类抗生素耐药的分子机制及其对多重耐药的影响 Jun Zhou and others The Journal of Infectious Diseases, Volume 233, Issue Supplement_1, 15 March 2026, Pages S10–S20, https://doi.org/10.1093/infdis/jiaf385 3 Molecular Epidemiology and Persistence of Multidrug-Resistant Acinetobacter baumannii in Zhejiang, China (2015–2020): Insights Into Resistance, Virulence, and Transmission Dynamics 2015 - 2020年中国浙江地区多重耐药鲍曼不动杆菌的分子流行病学及持久性：对耐药性、毒力和传播动态的见解 Yisha Zhang and others The Journal of Infectious Diseases, Volume 233, Issue Supplement_1, 15 March 2026, Pages S21–S30, https://doi.org/10.1093/infdis/jiaf425 4 Clinical Outcomes in Hypervirulent Carbapenem-Resistant Klebsiella pneumoniae Infection: A Cohort Study 高毒力碳青霉烯耐药肺炎克雷伯菌感染的临床预后：一项队列研究 Ya Hu and others The Journal of Infectious Diseases, Volume 233, Issue Supplement_1, 15 March 2026, Pages S31–S37, https://doi.org/10.1093/infdis/jiaf460 5 Reduced Susceptibility to Cefepime–Taniborbactam in Carbapenem-Resistant Klebsiella pneumoniae Attributed to Penicillin-Binding Protein 3 Modifications 碳青霉烯耐药肺炎克雷伯菌中因青霉素结合蛋白3修饰导致对头孢吡肟-他尼硼巴坦敏感性降低 Baofang Zhang and others The Journal of Infectious Diseases, Volume 233, Issue Supplement_1, 15 March 2026, Pages S38–S46, https://doi.org/10.1093/infdis/jiaf463 6 Isolation of Lytic Bacteriophages Against Carbapenem-Resistant Klebsiella pneumoniae of Capsular Type KL64 From Water Collected at Multiple Sites Across China 从中国多个地点采集的水样中分离出针对荚膜型KL64碳青霉烯耐药肺炎克雷伯菌的溶菌性噬菌体 Juan Li and others The Journal of Infectious Diseases, Volume 233, Issue Supplement_1, 15 March 2026, Pages S47–S55, https://doi.org/10.1093/infdis/jiaf607 7 Clinical and Molecular Characteristics of Carbapenem-Resistant Klebsiella pneumoniae Causing Bloodstream Infection in a Chinese Teaching Hospital 中国某教学医院引起血流感染的碳青霉烯耐药肺炎克雷伯菌的临床和分子特征 Quanfeng Liao and others The Journal of Infectious Diseases, Volume 233, Issue Supplement_1, 15 March 2026, Pages S56–S63, https://doi.org/10.1093/infdis/jiaf613 8 OmpK35 and OmpK36 Deficiencies Driving High-level Carbapenem Resistance in ST11 Klebsiella Pneumoniae OmpK35和OmpK36缺失导致ST11型肺炎克雷伯菌高水平碳青霉烯耐药 Jiayuan Qin and others The Journal of Infectious Diseases, Volume 233, Issue Supplement_1, 15 March 2026, Pages S64–S71, https://doi.org/10.1093/infdis/jiaf621 9 Carbapenem-Resistant Klebsiella pneumoniae of Sequence Type 11: A Scoping Review 序列型11的碳青霉烯耐药肺炎克雷伯菌：一项范围综述 Yongqiang Yang and others The Journal of Infectious Diseases, Volume 233, Issue Supplement_1, 15 March 2026, Pages S72–S80, https://doi.org/10.1093/infdis/jiaf635 10 Emergence of Carbapenem-Resistant Escherichia coli Coharboring blaCTX-M-199 and Penicillin-Binding Protein 3 Insertion Conferring Increased Aztreonam/Avibactam Resistance in South China 中国南方出现携带blaCTX-M-199且青霉素结合蛋白3插入导致氨曲南/阿维巴坦耐药性增强的碳青霉烯耐药大肠埃希菌 Jiong Wang and others The Journal of Infectious Diseases, Volume 233, Issue Supplement_1, 15 March 2026, Pages S81–S91, https://doi.org/10.1093/infdis/jiag025 11 Challenges and Strategies in Managing β-Lactam–Resistant Pseudomonas aeruginosa in China 中国应对β-内酰胺酶类抗生素耐药的铜绿假单胞菌所面临的挑战和策略 Yue Li and others The Journal of Infectious Diseases, Volume 233, Issue Supplement_1, 15 March 2026, Pages S92–S103, https://doi.org/10.1093/infdis/jiag033 12 New Delhi Metallo-β-Lactamase Carbapenem-Resistant Klebsiella pneumoniae in Neonates: A Genome-Based Surveillance Study 新生儿中新德里金属β-内酰胺酶碳青霉烯耐药肺炎克雷伯菌：一项基于基因组的监测研究 Liting Liang and others The Journal of Infectious Diseases, Volume 233, Issue Supplement_1, 15 March 2026, Pages S104–S112, https://doi.org/10.1093/infdis/jiag034 13 Trends of Carbapenem-Resistant Gram-negative Bacteria in China: A Surveillance Study Between 2015 and 2024 2015 - 2024年中国碳青霉烯耐药革兰氏阴性菌的趋势：一项监测研究 Yan Guo and others The Journal of Infectious Diseases, Volume 233, Issue Supplement_1, 15 March 2026, Pages S113–S117, https://doi.org/10.1093/infdis/jiag083 The Journal of Infectious Diseases. Volume 233 Issue 4 传染病杂志 233卷 4期 https://academic.oup.com/jid/issue/ Editorial（社论） 1 The Editors' Update: JID Continues to Evolve 社论更新：《传染病杂志》持续发展 Cornelius J (Neil) Clancy and others The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 619–620, https://doi.org/10.1093/infdis/jiag159 2 Protocols for Randomized Controlled Trials: Advancing Transparency in Infectious Diseases 随机对照试验方案：提高传染病研究的透明度 Jean-Jacques Parienti and others The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Page 621, https://doi.org/10.1093/infdis/jiag134 3 Dissecting the Impact of the Gut Microbiome on HIV Reservoir Dynamics 剖析肠道微生物组对HIV储存库动态的影响 Christopher M Basting and Nichole R Klatt The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 622–624, https://doi.org/10.1093/infdis/jiaf560 Viewpoint（观点） 4 Doxycycline Post-exposure Prophylaxis and Off-target Antimicrobial Resistance: Potential Amplification Within Sexual Networks 多西环素暴露后预防用药与非靶向抗菌药物耐药性：性网络内潜在的耐药性放大 Manon Roberts and Peter Davis The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 625–627, https://doi.org/10.1093/infdis/jiaf439 5 Clearing the Air: Rethinking Airway Infection With CFTR Modulators 清除迷雾：重新思考囊性纤维化跨膜转导调节因子调节剂治疗下的气道感染 Edith T Zemanick and Ranjani Somayaji The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 628–630, https://doi.org/10.1093/infdis/jiaf625 Invited ID Translational Science Update（特邀传染病转化医学更新） 6 Microbiota, Mucus, and Modulators: Cystic Fibrosis Infection Pathogenesis in the Cystic Fibrosis Transmembrane Conductance Regulator Modulator Era 微生物群、黏液与调节剂：囊性纤维化跨膜转导调节因子调节剂时代囊性纤维化感染的发病机制 Christina S Thornton and others The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 631–639, https://doi.org/10.1093/infdis/jiaf626 Major Articles and Brief Reports（论著与简报） HIV/AIDs（人类免疫缺陷病毒/艾滋病） 7 HIV Reservoir Dynamics and Bacteriome Composition Along the Gut Axis 肠道轴上HIV储存库动态与细菌群组成 Mattia Trunfio and others The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 640–651, https://doi.org/10.1093/infdis/jiaf546 8 Mitochondrial DNA Fragment Dynamics in Acute and Chronic Human Immunodeficiency Virus: Insights From Human and Nonhuman Primate Models 急性和慢性人类免疫缺陷病毒感染中线粒体DNA片段动态：来自人类和非人类灵长类动物模型的见解 Jing Sun and others The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 652–663, https://doi.org/10.1093/infdis/jiag014 9 Multiancestry Genome-Wide Association Study Identifies Variants in a Zinc Finger Gene Cluster as Novel Regulators of HIV Control 多祖先全基因组关联研究确定锌指基因簇中的变异体作为HIV控制的新型调节因子 Abraham Awada and others The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 664–673, https://doi.org/10.1093/infdis/jiag072 Bacterial Disease Pathogenesis（细菌性疾病发病机制） 10 Respiratory Syncytial Virus–Mediated Gas6/Axl Axis Induces Hyporesponsive Macrophages to Promote Pneumococcal Proliferation in the Nasopharynx 呼吸道合胞病毒介导的Gas6/Axl轴诱导巨噬细胞低反应性以促进鼻咽部肺炎链球菌增殖 Saki Ishikawa and others The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 674–684, https://doi.org/10.1093/infdis/jiag004 11 Variable Staphylothrombin Activity in Staphylococcus aureus Bloodstream Infections 金黄色葡萄球菌血流感染中可变的葡萄球菌凝血酶活性 Gregory L Damhorst and others The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 685–695, https://doi.org/10.1093/infdis/jiag012 12 TLR4–MyD88–NF-κB Signaling in the Airway Epithelium Promotes Acinetobacter baumannii Clearance 气道上皮细胞中的TLR4-MyD88-NF-κB信号通路促进鲍曼不动杆菌的清除 Jisun Kim and others The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 696–705, https://doi.org/10.1093/infdis/jiag061 Viral Disease Pathogenesis（病毒性疾病发病机制） 13 Ganciclovir Dosing in Premature Infants Receiving Treatment for Congenital Cytomegalovirus Infection: Results of a Prospective Pharmacokinetic Study 先天性巨细胞病毒感染接受治疗的早产儿更昔洛韦剂量：一项前瞻性药代动力学研究结果 Edward P Acosta and others The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 706–713, https://doi.org/10.1093/infdis/jiaf528 14 National- and State-level SARS-CoV-2 Immunity Trends From January 2020 to December 2023: a Mathematical Modeling Analysis 2020年1月至2023年12月国家及州级SARS-CoV-2免疫趋势：一项数学建模分析 Fayette Klaassen and others The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 714–724, https://doi.org/10.1093/infdis/jiaf532 15 Risk- and Response-Adapted Treatment in Pediatric Epstein-Barr Virus–Associated Hemophagocytic Lymphohistiocytosis 儿童EB病毒相关噬血细胞性淋巴组织细胞增生症的风险和反应适应性治疗 Jing Miao and others The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 725–734, https://doi.org/10.1093/infdis/jiaf556 16 IPVS Consensus Statement on The Natural History of Cervical Human Papillomavirus Infection 国际乳头瘤病毒学会关于宫颈人乳头瘤病毒感染自然史的共识声明 Marc D Ryser and others The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 735–744, https://doi.org/10.1093/infdis/jiaf574 17 Long Non-Coding RNA NEAT1 Inhibits Enterovirus 71 Replication by Enhancing IFN-β Transcription Through DDX60 Signaling: Pathological Insights and Clinical Implications 长链非编码RNA NEAT1通过DDX60信号增强IFN-β转录抑制肠道病毒71型复制：病理学见解与临床意义 Dong Li and others The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 745–757, https://doi.org/10.1093/infdis/jiaf578 18 A Threshold in Anti–EBNA-1 Antibody Titers Distinguishes Salivary EBV Shedders From Nonshedders 抗EBNA-1抗体滴度的阈值可区分唾液EB病毒脱落者与非脱落者 João Vitor Mahler and others The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 758–762, https://doi.org/10.1093/infdis/jiag010 Tuberculosis（结核病） 19 Tuberculosis Disease Prevalence Among People Who Smoke Illicit Drugs: A Respondent- Driven Sampling Study in the Western Cape, South Africa 南非西开普省使用受访者驱动抽样法研究吸食非法毒品者中结核病的患病率 Samantha Malatesta and others The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 763–772, https://doi.org/10.1093/infdis/jiaf481 20 Childhood Tuberculosis and Risk of Frailty in Later Life: Evidence From a Nationally Representative Study in Brazil 巴西一项全国代表性研究显示儿童期结核病与晚年衰弱风险的关系 Evelyn Lepka de Lima and Márlon Juliano Romero Aliberti The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 773–776, https://doi.org/10.1093/infdis/jiaf563 21 A Monovalent SMAC Mimetic as a Potential Host-Directed Therapy for Tuberculosis 单价SMAC模拟物作为结核病潜在宿主导向疗法 Jiahong Ji and others The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 777–786, https://doi.org/10.1093/infdis/jiag031 22 Cerebrospinal Fluid Hypo-inflammation Drives Mortality in HIV-Associated Tuberculous Meningitis 脑脊液低炎症反应是HIV相关结核性脑膜炎死亡的原因 Anna L Wilt and others The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 787–798, https://doi.org/10.1093/infdis/jiag032 Editorial（社论） 23 Guiding Lines: Practical and Accessible Approaches for Analyzing Serological Data for Infectious Disease Surveillance 指导方针：用于传染病监测的血清学数据分析的实用且易获取的方法 Laura C Steinhardt The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e850–e852, https://doi.org/10.1093/infdis/jiag054 Perspectives（观点） 24 Commensal Bacteria: An Under-recognized Cause of Pneumonia 共生菌：一种被忽视的肺炎病因 Daniel M Musher and others The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e853–e856, https://doi.org/10.1093/infdis/jiag053 25 The Role of Antiviral Treatment of Influenza in Reducing Hospitalizations and Other Severe Outcomes: A Need for More Evidence 抗病毒治疗流感在减少住院和其他严重结局方面的作用：需要更多证据 Mark W Tenforde and others The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e857–e861, https://doi.org/10.1093/infdis/jiaf573 Major Articles and Brief Reports（论著与简报） Special Report（专题报告） 26 Whose Line Is it Anyway? Defining Seropositivity Cutoffs for Infectious Disease Surveillance 究竟以谁为准？确定传染病监测血清阳性临界值 Michael T White and others The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e862–e871, https://doi.org/10.1093/infdis/jiaf537 Parasites（寄生虫） 27 Quantifying the Role of Importation on Sustained Malaria Transmission in a Low-to-Moderate Burden Region of Southwest Uganda 量化输入在维持乌干达西南部低至中度负担地区疟疾持续传播中的作用 Adrienne Epstein and others The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e872–e881, https://doi.org/10.1093/infdis/jiag008 28 Antibody-Dependent Neutrophil Phagocytosis of Plasmodium falciparum–Infected Erythrocytes Is Mediated by FcγRIIa 抗体依赖的中性粒细胞吞噬恶性疟原虫感染的红细胞由FcγRIIa介导 Maria Saeed and others The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e882–e890, https://doi.org/10.1093/infdis/jiag071 29 Comparison of CD4 T-Cell Response in Plasmodium falciparum and vivax Malaria 恶性疟原虫和间日疟原虫疟疾中CD4 T细胞反应的比较 Mayimuna Nalubega and others The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e891–e901, https://doi.org/10.1093/infdis/jiag115 HIV/AIDs（人类免疫缺陷病毒/艾滋病） 30 Persistent Increased Plasmacytoid Dendritic Cells and Inflammation in People With HIV Years After Tuberculosis 结核病治愈数年后，HIV感染者体内浆细胞样树突状细胞持续增多且炎症反应持续存在 Maureen Ward and others The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e902–e912, https://doi.org/10.1093/infdis/jiaf499 31 Neuroaxonal Injury in Acute HIV Infection and Following Immediate Antiretroviral Therapy 急性HIV感染期及立即接受抗逆转录病毒治疗后出现的神经轴突损伤 Phillip Chan and others The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e913–e922, https://doi.org/10.1093/infdis/jiaf583 32 Weekly Oral Prophylaxis With MK-8527 Protects Rhesus Macaques From Intrarectal Challenge With Simian–Human Immunodeficiency Virus 每周口服MK-8527进行预防可保护恒河猴免受猴-人免疫缺陷病毒的直肠攻击 Tracy L Diamond and others The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e923–e931, https://doi.org/10.1093/infdis/jiaf610 33 Partial Post-exposure Protection by Topical Inserts Containing Tenofovir Alafenamide Fumarate/Elvitegravir in a Macaque Model of Rectal Simian HIV (SHIV) Infection 在猕猴直肠猴免疫缺陷病毒（SHIV）感染模型中，含富马酸替诺福韦艾拉酚胺/埃维替韦的局部插入物提供部分暴露后保护 Natalia Makarova and others The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e932–e936, https://doi.org/10.1093/infdis/jiaf611 34 Human Immunodeficiency Virus–Associated Proteomic Signature of Myocardial Fibrosis and Incident Heart Failure 人类免疫缺陷病毒相关心肌纤维化和偶发心力衰竭的蛋白质组学特征 Tess E Peterson and others The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e937–e947, https://doi.org/10.1093/infdis/jiag013 Bacterial Disease Pathogenesis（细菌性疾病发病机制） 35 Treatment of Pseudomonas by Removal of Cloaking Antibodies: Is Common Polysaccharide Antigen a Factor? 通过去除伪装抗体治疗铜绿假单胞菌感染：常见多糖抗原是否是一个因素？ Joshua N Monteith and others The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e948–e956, https://doi.org/10.1093/infdis/jiag002 36 High Prevalence and Genotypic Diversity of Persistent Chlamydia Trachomatis Infections Among South African Adolescent Girls and Young Women: A Tale of Two Cities 南非少女和年轻女性中持续性沙眼衣原体感染的患病率高且基因型多样：两个城市的对比情况 Smritee Dabee and others The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e957–e962, https://doi.org/10.1093/infdis/jiag023 37 The Effect of Pertussis Vaccination During Pregnancy on the Binding Epitopes and Avidity of Anti–Pertussis Toxin Immunoglobulin G Antibodies in Infants and Their Mothers 孕期接种百日咳疫苗对婴儿及其母亲体内抗百日咳毒素免疫球蛋白G抗体的结合表位和亲和力的影响 Aapo Knuutila and others The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e963–e972, https://doi.org/10.1093/infdis/jiag048 Tuberculosis（结核病） 38 Accuracy of the Phenotypic 1G Test to Detect Mycobacterium tuberculosis and Drug Resistance From Sputa in the US-Mexico Border 表型1G试验检测美国-墨西哥边境痰液中结核分枝杆菌及耐药性的准确性 Mia Aguirre and others The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e973–e980, https://doi.org/10.1093/infdis/jiaf638 39 Mycobacterium tuberculosis–Specific CFP-10/ESAT-6 CD4 and CD8 T-Cell Non-IFN-γ+ Responses Are Common in Young Kenyan Children Despite Low Reported Tuberculosis Exposure 尽管报告的结核病暴露率较低，但肯尼亚幼儿中仍普遍存在结核分枝杆菌特异性CFP-10/ESAT-6 CD4和CD8 T细胞非γ干扰素阳性反应 Sylvia M LaCourse and others The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e981–e989, https://doi.org/10.1093/infdis/jiag039 40 Modeling the Impact of Case Finding for Tuberculosis: The Role of Infection Dynamics 结核病病例发现的影响建模：感染动态的作用 Theresa S Ryckman and others The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e990–e998, https://doi.org/10.1093/infdis/jiag050 41 Population Pharmacokinetic Modeling of Standard- and High-Dose Rifampicin for Tuberculosis Preventive Therapy in the 2R2 Randomized Controlled Trial 2R2随机对照试验中用于结核病预防治疗的标准剂量和高剂量利福平的群体药代动力学建模 Fajri Gafar and others The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e999–e1010, https://doi.org/10.1093/infdis/jiag052 Viruses（病毒） 42 Improved Immune Response Against Influenza A Viruses With Receipt of a Recombinant Influenza Vaccine in Healthcare Personnel With Prior Low Antibody Response to Egg-Based Influenza Vaccines, Israel, 2019–2020 2019-2020年，以色列既往对基于鸡蛋的流感疫苗抗体反应低的医护人员接种重组流感疫苗后，对甲型流感病毒的免疫反应有所改善 Kelsey M Sumner and others The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e1011–e1021, https://doi.org/10.1093/infdis/jiaf605 43 Antineuraminidase Antibody Responses in Older Adults After Consecutive Vaccinations With Enhanced Influenza Vaccines: A Randomized Controlled Trial 老年人连续接种强化流感疫苗后抗神经氨酸酶抗体反应：一项随机对照试验 Pavithra Daulagala and others The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e1022–e1030, https://doi.org/10.1093/infdis/jiaf616 44 The Pandemic Respiratory Virus Epidemiological Surveillance Trial-A Self-swab Surveillance System for Respiratory Viruses Nested Within FluTracking 大流行性呼吸道病毒流行病学监测试验——嵌入FluTracking的呼吸道病毒自我拭子监测系统 Camille Esneau and others The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e1031–e1039, https://doi.org/10.1093/infdis/jiaf632 45 Intracellular Ganciclovir Triphosphate Concentrations in Children With Congenital Cytomegalovirus Infection 先天性巨细胞病毒感染患儿体内更昔洛韦三磷酸的细胞内浓度 Brent Lindquist-Kleissler and others The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e1040–e1045, https://doi.org/10.1093/infdis/jiaf633 46 Hepatitis E Virus Infection in Patients With Chronic Liver Diseases: A Latin American Multicenter Study 拉丁美洲多中心研究：慢性肝病患者中的戊型肝炎病毒感染情况 Anabella Clara Fantilli and others The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e1046–e1055, https://doi.org/10.1093/infdis/jiaf615 47 In Vivo Risk Assessment of Yellow Fever Virus Transmission Through Breastfeeding, and Mechanistic Insights 母乳喂养传播黄热病病毒的体内风险评估及机制研究 Jeanne Pascard and others The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e1056–e1068, https://doi.org/10.1093/infdis/jiaf637 Letters to the Editor（致编辑的信） 48 Re: Estimating the Early Transmission Inhibition of New Treatment Regimens for Drug-Resistant Tuberculosis 回复：估算耐药结核病新治疗方案对早期传播的抑制作用 Tom A Yates and David A Barr The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e1069–e1070, https://doi.org/10.1093/infdis/jiaf655 49 Reply to Yates and Barr 回复耶茨和巴尔 Ruvandhi R Nathavitharana and others The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e1071–e1072, https://doi.org/10.1093/infdis/jiaf656 50 How “Enhanced” Are Enhanced Influenza Vaccines for Neuraminidase? Antigen Content and Baseline Immunity Revisited 强化流感疫苗对神经氨酸酶的“强化”程度如何？重新审视抗原含量和基线免疫力 Xiaowei Zhang The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e1073–e1074, https://doi.org/10.1093/infdis/jiag042 51 Response to Letter to the Editor Regarding the Immunogenicity of Enhanced Influenza Vaccines in Inducing Neuraminidase Inhibition Antibodies 回复致编辑的关于“强化流感疫苗诱导神经氨酸酶抑制抗体免疫原性”的信 Pavithra Daulagala and others The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e1075–e1076, https://doi.org/10.1093/infdis/jiag043 52 Comment on B-Cell Subset Representation Predicts SARS-CoV-2 Vaccine Response in Solid Organ Transplant Recipients 关于“B细胞亚群表征预测实体器官移植受者对SARS-CoV-2疫苗反应”的评论 Pınar Belviranlı Keskin The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Page e1077, https://doi.org/10.1093/infdis/jiag055 53 Response to Dr Belviranli Keskin's Comments 回复贝尔维兰利·凯斯金的评论 James J Knox and others The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Page e1078, https://doi.org/10.1093/infdis/jiag056 54 Beyond Antibodies: Influenza Vaccine Induced T-Cell Response in Hematological Malignancy— Commentary on Insights From Hall et al 超越抗体：流感疫苗在血液系统恶性肿瘤患者中诱导的T细胞反应——对霍尔等人见解的评论 Katja M Sauer and others The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e1079–e1080, https://doi.org/10.1093/infdis/jiag079 55 Advancing Understanding of Viral Interference: Insights From Rhinovirus–SARS-CoV-2 Cross-protection and Immunologic Perspectives 加深对病毒干扰的理解：来自鼻病毒-SARS-CoV-2交叉保护和免疫学视角的见解 Weikai Dong and others The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e1081–e1082, https://doi.org/10.1093/infdis/jiag080 56 When PD-1 Meets Plaque: Making CD8 Senescence Signals Clinically Actionable in Treated HIV 当PD-1遇上斑块：使治疗后的HIV感染者中CD8细胞衰老信号具有临床可操作性 Xiaowei Zhang The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e1083–e1084, https://doi.org/10.1093/infdis/jiag081 The Journal of Infectious Diseases. Volume 233 Issue 5 传染病杂志 233卷 5期 https://academic.oup.com/jid/issue/ Editorial（社论） 1 Beyond Transplantation: Cytomegalovirus Viremia as a Therapeutic Target in Non-Cytomegalovirus Syndromes 超越移植：巨细胞病毒血症作为非巨细胞病毒综合征的治疗靶点 Ghady Haidar The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 799–801, https://doi.org/10.1093/infdis/jiaf648 2 When Time Is of the Essence: Hepatitis C Virus RNA Point-of-Care Testing in 15Minutes Becomes a Reality 当时间至关重要：15分钟内完成丙型肝炎病毒RNA即时检测成为现实 Tanya L Applegate and Jason Grebely The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 802–805, https://doi.org/10.1093/infdis/jiaf652 Trainee’s Corner（实习生专栏） 3 The Day I Was Told I Wasn’t Doing Science—And Why I’m Grateful for It 被告知我没有在做科学的那一天——以及我为何对此心怀感激 Sara Gianella The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 806–808, https://doi.org/10.1093/infdis/jiaf614 JID Viewpoint（《传染病杂志》观点） 4 Restoring TB-specific Immunity in Early HIV Infection—the Dual Promise of Early Antiretroviral and TB Preventive Treatment 在HIV感染早期恢复结核特异性免疫——早期抗逆转录病毒治疗与结核预防性治疗的双重前景 Patrick K Moonan and others The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 809–811, https://doi.org/10.1093/infdis/jiaf518 Major Articles and Brief Reports（主要论著与简报） Viral Disease Pathogenesis（病毒性疾病发病机制） 5 Cytomegalovirus DNAemia in Hospitalized Adults With SARS-CoV-2 Infection Requiring Supplemental Oxygen: Virologic and Clinical Characteristics and Association With Outcomes 需要补充氧疗的住院成人SARS-CoV-2感染患者中的巨细胞病毒DNA血症：病毒学与临床特征及其与预后的关系 Michael Boeckh and others The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 812–822, https://doi.org/10.1093/infdis/jiaf649 6 Development of a Rapid Automated Point-of-Care Test for Hepatitis C Viral RNA on the DASH Rapid Polymerase Chain Reaction System 基于DASH快速聚合酶链反应系统的丙型肝炎病毒RNA快速自动化即时检测的开发 Jennifer L Reed and others The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 823–830, https://doi.org/10.1093/infdis/jiaf608 7 Serum Markers of Fibroinflammatory Activity PRO-C3 and CPa9-HNE Are Associated with Liver-Related Outcomes in Patients with Chronic Hepatitis C 纤维炎症活动血清标志物PRO-C3和CPa9-HNE与慢性丙型肝炎患者肝脏相关预后有关 Emilie Toft Skovgaard and others The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 831–839, https://doi.org/10.1093/infdis/jiaf552 8 A Rapid Assay for Hepatitis C Virus RNA Detection Using Reverse-Transcription Loop-Mediated Isothermal Amplification–Coupled CRISPR-Cas12b–Based Strategy 基于逆转录环介导等温扩增联合CRISPR-Cas12b策略的丙型肝炎病毒RNA快速检测方法 Avisha Chowdhury and others The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 840–847, https://doi.org/10.1093/infdis/jiaf609 9 Maternal-Fetal Letermovir Exposure In Vivo and Physiologically Based Pharmacokinetic Modeling: A Rationale for Congenital Cytomegalovirus Therapy 体内母胎来特莫韦暴露及生理药代动力学建模：先天性巨细胞病毒治疗的理论基础 Valentine Faure Bardon and others The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 848–857, https://doi.org/10.1093/infdis/jiaf619 10 Feasibility and Safety of Aerosolized Influenza Virus Challenge in Humans Using Two Modern Delivery Systems 使用两种现代递送系统进行雾化流感病毒人体激发的可行性与安全性 Nadine Rouphael and others The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 858–867, https://doi.org/10.1093/infdis/jiaf603 11 Rhinovirus-Associated Lower Respiratory Tract Infection in Hospitalized Adult Patients: A Retrospective Cohort Study 住院成人患者中与鼻病毒相关的下呼吸道感染：一项回顾性队列研究 Rongling Zhang and others The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 868–876, https://doi.org/10.1093/infdis/jiaf651 Bacterial Disease Pathogenesis（细菌性疾病发病机制） 12 Decoding Hypervirulence in Carbapenem-Resistant Klebsiella pneumoniae: Genomic and Phenotypic Profiling Reveals Capsular Polysaccharide as a Key Driver of Pathogenicity 解码碳青霉烯耐药肺炎克雷伯菌的高毒力：基因组与表型分析揭示荚膜多糖是致病性的关键驱动因素 Li Xu and others The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 877–887, https://doi.org/10.1093/infdis/jiag075 13 Inflammatory Cytokine Profile in Pregnant Women Colonized With Group B Streptococcus Reveals IL-17a as a Potential Biomarker to Identify at-risk Newborns B族链球菌定植孕妇的炎症细胞因子谱显示IL-17a可作为识别高危新生儿的潜在生物标志物 Narjis Amar and others The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 888–898, https://doi.org/10.1093/infdis/jiag092 14 Epitope-Based Multimeric Subunit Vaccine (ATOMSSUISpenta) Confers Broad Protection Against Streptococcus suis Infection 表位基多聚体亚单位疫苗（ATOMSSUISpenta）对猪链球菌感染提供广泛保护 Sun-Young Kim and others The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 899–911, https://doi.org/10.1093/infdis/jiag131 Parasites（寄生虫） 15 Pfs230 Domains 7–10 Encoded by DNA Vaccines Induce Potent Complement-Independent Transmission-Blocking Antibody Against Plasmodium falciparum DNA疫苗编码的Pfs230结构域7–10可诱导强效非补体依赖性抗恶性疟原虫传播阻断抗体 Yi Cao and others The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 912–923, https://doi.org/10.1093/infdis/jiaf555 16 Uneven Plasmodium falciparum Transmission and Cryptic ovale Transmission From the Asymptomatic Reservoir in Bagamoyo, Tanzania 坦桑尼亚巴加莫约无症状感染库中恶性疟原虫传播不均与隐匿性卵形疟原虫传播 Jessica T Lin and others The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 924–933, https://doi.org/10.1093/infdis/jiaf634 17 Mzb1 Promotes Progression of Schistosomiasis by Inducing Endoplasmic Reticulum Stress Mzb1通过诱导内质网应激促进血吸虫病进展 Lanyue Pan and others The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 934–945, https://doi.org/10.1093/infdis/jiaf639 Antimicrobial Resistance (AMR)（抗生素耐药） 18 Longitudinal Trends in Pediatric Non-Salmonella Gram-Negative Enterobacterales Infections at a Tertiary Care Center in West Africa, 2005–2023 西非一家三级医疗中心2005–2023年儿童非沙门氏菌革兰阴性肠杆菌科感染的纵向趋势 Sumanth Cherukumilli and others The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 946–956, https://doi.org/10.1093/infdis/jiag027 19 The Effect of a 5-Day Course of Azithromycin on Streptococcus Pneumoniae Carriage and Antimicrobial Resistance Among Kenyan Children Discharged From Hospital 阿奇霉素5天疗程对出院肯尼亚儿童肺炎链球菌携带率及抗菌药物耐药性的影响 Tanya E Libby and others The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 957–965, https://doi.org/10.1093/infdis/jiag028 20 Comparative Analysis of High-Dose Dual Therapies in First-Line Helicobacter pylori Eradication: An Inverse Probability of Treatment-Weighted Multicenter Study 高剂量双联方案一线幽门螺杆菌根除治疗的比较分析：一项逆概率加权多中心研究 Qingzhou Kong and others The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 966–974, https://doi.org/10.1093/infdis/jiag059 Editorial（社论） 21 Implementation Does Not Occur in a Vacuum: Sustaining a Comprehensive and Global Vision for HIV Research 实施并非在真空中发生：维持全面且全球化的HIV研究愿景 Sara Gianella and others The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1085–e1087, https://doi.org/10.1093/infdis/jiag063 22 Uncovering the Hidden Impacts of Modern Medicine's Expanding Pharmacopeia on Clostridioides difficile Infection Risk 揭示现代医学不断扩展的药物谱对艰难梭菌感染风险的隐性影响 Alison Laufer Halpin and L Clifford McDonald The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1088–e1091, https://doi.org/10.1093/infdis/jiag011 Perspectives（观点） 23 Future Directions for NIH HIV Research: A Look Ahead to 2026 美国国立卫生研究院HIV研究的未来方向：展望2026年 Geri R Donenberg and Robert W Eisinger The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1092–e1093, https://doi.org/10.1093/infdis/jiag062 ID Translational Science Update（传染病转化医学更新） 24 Immune Responses to Phage Therapy in Humans: A Review 人体对噬菌体疗法的免疫应答：综述 Kiran Bosco and others The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1094–e1103, https://doi.org/10.1093/infdis/jiag096 Major Articles and Brief Reports（主要论著与简报） Bacterial Disease Pathogenesis（细菌性疾病发病机制） 25 Antibiotic and Nonantibiotic Drugs Associated With Clostridioides difficile Infection Risk: a Pharmacopoeia-Wide Case-Cohort Study 与艰难梭菌感染风险相关的抗菌及非抗菌药物：一项全药物谱病例-队列研究 Kevin A Brown and others The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1104–e1114, https://doi.org/10.1093/infdis/jiag001 26 Age-Specific Concentrations and Seroprevalence of Antibodies Against Salmonella Enteritidis (O:9) and Salmonella Typhimurium (O:4,5) Across 3 Sites in Kenya 肯尼亚3个地区针对鼠伤寒沙门氏菌（O:9）和伤寒沙门氏菌（O:4,5）抗体的年龄特异性浓度与血清流行率 Esther M Muthumbi and others The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1115–e1123, https://doi.org/10.1093/infdis/jiag114 27 Influence of Chlamydia trachomatis Sequence Variation on pgp3 Antigenicity 沙眼衣原体序列变异对pgp3抗原性的影响 Filomeno Coelho da Silva and others The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1124–e1129, https://doi.org/10.1093/infdis/jiag067 28 Increased Diversity and Introduction of Multidrug-Resistant Strains of Neisseria gonorrhoeae Following Cessation of COVID-19 Pandemic–Related Travel Restrictions: An Observational Genomic Epidemiologic Study 新冠疫情相关旅行限制解除后淋病奈瑟菌多样性增加及多重耐药菌株的引入：一项观察性基因组流行病学研究 Rosa C Coldbeck-Shackley and others The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1130–e1140, https://doi.org/10.1093/infdis/jiag097 29 Disease-Attenuated Pneumococcal Biosynthesis Gene Mutants Invade the Mucosal Epithelium and Induce Innate Immunity 致病性减弱的肺炎链球菌生物合成基因突变体可侵入黏膜上皮并诱导先天免疫 Caroline M Weight and others The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1141–e1153, https://doi.org/10.1093/infdis/jiag124 HIV/AIDs（人类免疫缺陷病毒/艾滋病） 30 Functional and Transcriptional Senescence Profiles of CD8+ T Cells Associate With the Presence of Carotid Plaques in People Living With HIV HIV感染者中CD8+ T细胞的功能及转录衰老特征与颈动脉斑块有关 Marc J T Blaauw and others The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1154–e1164, https://doi.org/10.1093/infdis/jiag018 31 Estimating HIV-1 Viremic Time From Reservoir Sequence Diversity With Uncertainty Quantification 利用库序列多样性估算HIV-1病毒血症时间及不确定性量化 Edward N Kankaka and others The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1165–e1172, https://doi.org/10.1093/infdis/jiag020 32 Longitudinal Changes in Cognition and Brain Imaging in Persons With Human Immunodeficiency Virus 人类免疫缺陷病毒感染者认知功能与脑影像学的纵向变化 James Kennedy and others The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1173–e1180, https://doi.org/10.1093/infdis/jiag029 Antimicrobial Resistance (AMR)（抗生素耐药） 33 Epidemiological and Molecular Surveillance of Multiresistant Citrobacter freundii Complex in a Tertiary Care Hospital: A Retrospective Cohort Study 三级医疗机构中多重耐药弗氏柠檬酸杆菌复合群的流行病学与分子监测：一项回顾性队列研究 Pérince Fonton and others The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1181–e1192, https://doi.org/10.1093/infdis/jiag066 34 The Influence of National Antibiotic Consumption on Neisseria Gonorrhoeae Antibiotic Resistance in Norway, 2003–2024 2003–2024年挪威全国抗生素消耗对淋病奈瑟菌耐药性的影响 Patricia Campbell The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1193–e1202, https://doi.org/10.1093/infdis/jiag076 35 Restoration of Mucosa-Associated Invariant T-Cell Function in Healthcare-Associated Bacterial Infections Supports Recovery of Carbapenem Efficacy Against Resistant Bacteria Ex Vivo 医疗相关细菌感染中黏膜相关恒定T细胞功能的恢复支持碳青霉烯类药物对耐药菌疗效的体外恢复 Yiting Xue and others The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1203–e1214, https://doi.org/10.1093/infdis/jiag151 Parasites（寄生虫） 36 Febrile Temperature Augments Ring-stage Plasmodium falciparum Adhesion to Brain Endothelial Cells 发热温度增强环期恶性疟原虫对脑内皮细胞的黏附 Fatou Joof and others The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1215–e1225, https://doi.org/10.1093/infdis/jiaf474 37 Safety, Tolerability, and Pharmacokinetics of 6-Diazo-5-Oxo-L-Norleucine in Malawian Adults With and Without Malaria: A Phase 1 Dose-Escalation Clinical Trial 6-重氮-5-氧代-L-正亮氨酸在马拉维有无疟疾成年人群中的安全性、耐受性与药代动力学：一项1期剂量递增临床试验 Brittany A Riggle and others The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1226–e1237, https://doi.org/10.1093/infdis/jiag121 38 Tracking Plasmodium knowlesi Through Fecal DNA for Monitoring Zoonotic Transmission in Wild Macaques Across Southeast and South Asia 通过粪便DNA追踪诺氏疟原虫以监测东南亚和南亚野生猕猴中的人畜共患传播 Dhammika Leshan Wannigama and others The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1238–e1243, https://doi.org/10.1093/infdis/jiag128 Viruses（病毒） 39 Effectiveness of Measles-Mumps-Rubella Vaccination Among Persons Residing in a Congregate Migrant Shelter During a Measles Outbreak: An Observational Cohort Study 麻疹爆发期间聚集性移民收容所居住者麻疹-腮腺炎-风疹疫苗的有效性：一项观察性队列研究 Chelsea S Lutz and others The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1244–e1252, https://doi.org/10.1093/infdis/jiaf650 40 Quantifying the Impact of Switching From Rotarix to Rotavac Rotavirus Vaccine in Ghana 量化加纳从Rotarix转换为Rotavac轮状病毒疫苗的影响 Ernest O Asare and others The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1253–e1260, https://doi.org/10.1093/infdis/jiag003 41 Persistent T Cell Immunity Following Nipah Virus Infection: Evidence From Malaysian Survivors 尼帕病毒感染后T细胞免疫的持续存在：来自马来西亚幸存者的证据 Puteri Ainaa S Ibrahim and others The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1261–e1266, https://doi.org/10.1093/infdis/jiag017 42 Characterization of Mouse-Adapted Marburg and Ravn Viruses in Inbred BALB/c and Outbred CD-1 Mice BALB/c近交系与CD-1远交系小鼠中适应小鼠的马尔堡病毒与拉文病毒的特征研究 Katherine A Davies and others The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1267–e1272, https://doi.org/10.1093/infdis/jiag019 43 Cross-reactive H5N1 Neuraminidase Antibodies by Age and Influenza A Imprinting Cohorts of the Past Century: Population-Based Serosurvey, British Columbia, Canada 过去一个世纪不同年龄与甲型流感印记队列中H5N1神经氨酸酶交叉反应抗体：加拿大不列颠哥伦比亚省人群血清学调查 Danuta M Skowronski and others The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1273–e1284, https://doi.org/10.1093/infdis/jiag030 44 Inflammasome Activation and Oxidative Stress in SARS-CoV-2 Infection and Symptomatic Rebound SARS-CoV-2感染及症状反弹中的炎症小体激活与氧化应激 Silvia Lucena Lage and others The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1285–e1297, https://doi.org/10.1093/infdis/jiag037 Letters to the Editor（致编辑的信） 45 Reply to Gianella: Redefining Science Together 致Gianella的回复：共同重新定义科学 Rachel A Bender Ignacio The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1298–e1299, https://doi.org/10.1093/infdis/jiaf644 46 Response to the Day I Was Told I Wasn’t Doing Science—And Why I’m Grateful for It 对《被告知我没有在做科学的那一天——以及我为何对此心怀感激》的回应 Darcy Wooten The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Page e1300, https://doi.org/10.1093/infdis/jiag084 47 Reply to Gianella: Women in Academic Medicine Will Lead a Sea Change 致Gianella的回复：女性学者将引领学术医学的海变 Maile A Y Karris The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Page e1301, https://doi.org/10.1093/infdis/jiag109 48 Between Two Standards: Reflections on the Double Bind From a Female Chinese Infectious Disease Physician 两种标准之间：一位中国女性传染病医生对双重束缚的反思 Nan Xu The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1302–e1303, https://doi.org/10.1093/infdis/jiag101 49 When “Logistics”Becomes Science: A Research Coordinator's Response on Team-Based Discovery 当"后勤"变成科学：一位研究协调员关于团队协作发现的回应 Cheryl Dullano The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Page e1304, https://doi.org/10.1093/infdis/jiag102 50 Pushing the Stone Uphill Together 共同推石上山 Scott L Letendre The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1305–e1306, https://doi.org/10.1093/infdis/jiag125 The Journal of Infectious Diseases. Volume 233 Issue 6 传染病杂志 233卷 6期 https://academic.oup.com/jid/issue/ Editorial（社论） 1 Increasing Handgrip Strength to Combat Frailty in Human Immunodeficiency Virus: Linking Immune Exhaustion to a Bone Health Indicator 提高握力以对抗人类免疫缺陷病毒患者的衰弱：将免疫耗竭与骨健康指标相联系 Jean-Pierre Routy and Stephane Isnard The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages 975–976, https://doi.org/10.1093/infdis/jiag082 2 Immune Checkpoint Inhibition Therapy Beyond the Tumor: Implications for Hepatitis B Virus in Hepatocellular Carcinoma 免疫检查点抑制疗法在肿瘤之外的应用：对肝细胞癌中乙型肝炎病毒的启示 Renato Bobadilla and Arthur Y Kim The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages 977–980, https://doi.org/10.1093/infdis/jiag058 Perspective（观点） 3 The Recurring Issue of Syphilis in Europe: Comment on “Ancient Genomes Reveal a Deep History of Treponema pallidum in the Americas” 欧洲梅毒的反复问题——评《古代基因组揭示美洲苍白密螺旋体的深层历史》 M Dehmane and others The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages 981–982, https://doi.org/10.1093/infdis/jiag022 ID Translational Science Update（传染病转化医学最新动态） 4 Evidence-Based Assessment of the Role of Pharyngeal Gonorrhea and Commensal Neisseria Species in the Emergence of Antimicrobial Resistance in Neisseria Gonorrhoeae: Data Gaps and Future Research 咽部淋病与共生奈瑟菌属在淋病奈瑟菌耐药性出现中作用的循证评估：数据缺口与未来研究 Amber D Kimble and others The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages 983–994, https://doi.org/10.1093/infdis/jiag197 Major Articles and Brief Reports（论著与简报） HIV/AIDs（人类免疫缺陷病毒/艾滋病） 5 Frailty in People with HIV Is Linked to Inflammation, Bone Health, and T-Cell Exhaustion HIV感染者的衰弱与炎症、骨健康及T细胞耗竭相关 Michael L Freeman and others The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages 995–1004, https://doi.org/10.1093/infdis/jiag046 6 A New Type of Nonsuppressible Viremia Produced by HIV-Infected Macrophage HIV感染巨噬细胞产生的一种新型不可抑制性病毒血症 Matthew J Moeser and others The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages 1005–1014, https://doi.org/10.1093/infdis/jiag171 Viral Disease Pathogenesis（病毒性疾病发病机制） 7 Immune Checkpoint Inhibitor-Induced Rapid Decline in Hepatitis B Virus Markers Improves the Prognosis of Hepatitis B Virus–Related Hepatocellular Carcinoma Patients 免疫检查点抑制剂诱导的乙型肝炎病毒标志物快速下降改善乙肝相关肝细胞癌患者的预后 Yujie Ran and others The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages 1015–1026, https://doi.org/10.1093/infdis/jiag036 8 Nasal Biomarkers of Acute Illness Severity and Predictors of Recurrent Wheeze in Infants Infected With Respiratory Syncytial Virus 呼吸道合胞病毒感染婴儿的急性疾病严重程度的鼻部生物标志物及反复喘息的预测因素 Mary T Caserta and others The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages 1027–1035, https://doi.org/10.1093/infdis/jiag049 9 Epidemiological, Clinical, and Virological Characterizations of Yezo Virus Infections, an Emerging Tick-borne Orthonairovirus Disease in Japan 日本新兴蜱传正内罗病毒病——耶佐病毒感染的流行病学、临床及病毒学特征 Hiroki Yamaguchi and others The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages 1036–1045, https://doi.org/10.1093/infdis/jiag073 10 Single-Cell Sequencing Reveals Varying Cell-Mediated Immunity Profiles in Individuals With Distinct Antibody Responses Following Ad5-nCoV Booster 单细胞测序揭示Ad5-nCoV加强针接种后不同抗体应答者的细胞免疫谱差异 Conghui Liao and others The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages 1046–1057, https://doi.org/10.1093/infdis/jiag078 11 Middle East Respiratory Syndrome Coronavirus–Specific T-Cell Responses in Dromedary Camel Abattoir Workers in Nigeria Suggests Frequent Zoonotic Spillover 尼日利亚单峰驼屠宰场工人中中东呼吸综合征冠状病毒特异性T细胞反应提示频繁的人畜共患溢出 Chris K P Mok and others The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages 1058–1062, https://doi.org/10.1093/infdis/jiag095 12 Incidence and Severity of Postacute Sequelae of SARS-CoV-2 Infection in the Omicron Era: A Prospective Cohort Study 奥密克戎时代SARS-CoV-2感染后急性后遗症的发生率与严重程度：一项前瞻性队列研究 Dan-Yu Lin and others The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages 1063–1068, https://doi.org/10.1093/infdis/jiag026 Bacterial Disease Pathogenesis（细菌性疾病发病机制） 13 Real-World Effectiveness of Sequential Pneumococcal Vaccination in Older Adults: A Cohort Study 老年人序贯肺炎球菌疫苗接种的现实有效性：一项队列研究 Yong Yi Tan and others The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages 1069–1080, https://doi.org/10.1093/infdis/jiag147 14 Safety and Immunogenicity of a Trivalent Salmonella Conjugate Vaccine to S. Typhi, S. Typhimurium, and S. Enteritidis 针对伤寒沙门氏菌、鼠伤寒沙门氏菌和肠炎沙门氏菌的三价沙门氏菌结合疫苗的安全性与免疫原性 Wilbur H Chen and others The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages 1081–1090, https://doi.org/10.1093/infdis/jiag156 15 The Natural History of Mycoplasma genitalium in the Pharynx and Rectum in a Cohort of Men Who Have Sex With Men: Prevalence, Incidence, Duration, and Symptoms 生殖支原体在男男性行为者咽部和直肠中的自然史：患病率、发病率、持续时间及症状 Lindley A Barbee and others The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages 1091–1099, https://doi.org/10.1093/infdis/jiag173 16 A Genomic Analysis of Community-Associated C. difficile Infection Demonstrates Integration With National and International Strain Clusters and Limited Direct Transmission 社区相关性艰难梭菌感染的基因组分析显示其与国内外菌株簇的整合及有限的直接传播 Nicole D Pecora and others The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages 1100–1109, https://doi.org/10.1093/infdis/jiag176 Antimicrobial Resistance (AMR)（抗生素耐药） 17 Recurrent Plasmodium falciparum Parasitemia and Drug Resistance Mutations During Intermittent Preventive Treatment of Malaria in Pregnancy in Uganda 乌干达妊娠期疟疾间歇性预防治疗期间恶性疟原虫复现及耐药突变 Jimmy Kizza and others The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages 1110–1119, https://doi.org/10.1093/infdis/jiag074 18 Stepwise Evolution of Triple Antimicrobial Resistance in Neisseria meningitidis 脑膜炎奈瑟菌三重耐药性的逐步演化 José Eduardo O Marín and others The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages 1120–1129, https://doi.org/10.1093/infdis/jiag113 19 Asymptomatic Screening for Neisseria gonorrhoeae Among Gay and Bisexual Men Attending Public Sexual Health Services in Australia and Associations With Patterns of Ceftriaxone Consumption: A Retrospective Observational Study 澳大利亚男男性行为者在公共性健康服务机构中淋病奈瑟菌无症状筛查及其与头孢曲松消费模式的关联：一项回顾性观察研究 Arthur Wong and others The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages 1130–1140, https://doi.org/10.1093/infdis/jiag192 Editorial（社论） 20 Cytomegalovirus and Aging—How Can the Field Move Forward? 巨细胞病毒与衰老——该领域如何向前推进？ Michael Boeckh and Lawrence Corey The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1307–e1309, https://doi.org/10.1093/infdis/jiag099 21 New Insights From Perinatal HIV: A Way Forward for HIV Cure Research 围产期HIV的新见解——HIV治愈研究的前进方向 Rajesh T Gandhi and others The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1310–e1312, https://doi.org/10.1093/infdis/jiag057 ID Translational Science Update（传染病转化医学最新动态） 22 What's Hot in HIV in 2025—A Basic and Translational Science Review From IDWeek 2025 2025年HIV研究热点——IDWeek 2025基础与转化医学综述 Ana Rafaela Teixeira and Marina Caskey The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1313–e1319, https://doi.org/10.1093/infdis/jiag135 Major Articles and Brief Reports（论著与简报） Viruses（病毒） 23 A Pathogen Penalty? Associations Between Persistent Infections and Biological Aging in the US 病原体惩罚？美国持续感染与生物学衰老之间的关联 Jennifer Momkus and others The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1320–e1329, https://doi.org/10.1093/infdis/jiaf606 24 Transient Interferon-Driven Natural Killer Cell Activation in Acute Hepatitis C 急性丙型肝炎中一过性干扰素驱动的自然杀伤细胞激活 Benedikt Strunz and others The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1330–e1340, https://doi.org/10.1093/infdis/jiaf654 25 Risk-Based Prophylactic Human Papillomavirus Vaccination of Heterosexual US Men Aged 27 to 45 Years for Prevention of Oropharyngeal Cancer 基于风险用以预防口咽癌的美国男性27至45岁异性恋人群预防性人乳头瘤病毒疫苗接种 Anil K Chaturvedi and others The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1341–e1344, https://doi.org/10.1093/infdis/jiag038 26 Machine Learning–Enabled Quantification of Hepatocellular Necrosis in the Liver After Lethal Marburg and Ebola Virus Exposures 机器学习辅助定量分析致死性马尔堡病毒和埃博拉病毒暴露后肝脏肝细胞坏死程度 Yanling Liu and others The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1345–e1354, https://doi.org/10.1093/infdis/jiag040 27 Influenza Vaccination Effectiveness Against Influenza-Associated Hospitalization in Children and the Effects of Repeated Vaccination 流感疫苗对儿童流感相关住院的有效性及重复接种的影响 Xuan Yu and others The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1355–e1363, https://doi.org/10.1093/infdis/jiag047 28 Repeat Influenza Vaccination Effects in 2021/22 and 2022/23 in a Community-Based Cohort in Hong Kong 2021/22及2022/23季香港社区队列中重复接种流感疫苗的效果 Jennifer C Zhong and others The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1364–e1373, https://doi.org/10.1093/infdis/jiag051 29 Anti-spike IgG Avidity Enhances Neutralization of Severe Acute Respiratory Syndrome Coronavirus 2: A Prospective Study of Primary Infections and Immunizations 抗刺突蛋白IgG亲合力增强对严重急性呼吸综合征冠状病毒2的中和作用：初次感染与免疫接种的前瞻性研究 Visa Nurmi and others The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1374–e1385, https://doi.org/10.1093/infdis/jiag068 30 Genomic Evolution of Influenza A Virus During the 2024–2025 Season, the Johns Hopkins Health System: Antigenic Drift Reduces Serum Neutralization 2024—2025季约翰斯·霍普金斯卫生系统中甲型流感病毒的基因组进化：抗原漂移降低血清中和能力 David Villafuerte and others The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1386–e1395, https://doi.org/10.1093/infdis/jiag069 HIV/AIDs（人类免疫缺陷病毒/艾滋病） 31 Dynamics of Intact and Defective Human Immunodeficiency Virus Type 1 (HIV-1) Proviruses During Decades of Suppressive Antiretroviral Treatment in Young Adults With Perinatal HIV 围产期感染HIV青年人在数十年抑制性抗逆转录病毒治疗期间完整与缺陷型人类免疫缺陷病毒1型（HIV-1）前病毒的动态变化 Priya Khetan and others The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1396–e1406, https://doi.org/10.1093/infdis/jiag045 32 Unsuppressed Viremia and Lower CD4 Count Associated With Faster Telomere Attrition in African Children With Perinatal Human Immunodeficiency Virus on Long-term Antiretroviral Therapy 未抑制的病毒血症及较低CD4计数与长期接受抗逆转录病毒治疗的非洲围产期感染HIV的儿童端粒加速缩短相关 Julian P G Shellard and others The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1407–e1417, https://doi.org/10.1093/infdis/jiag060 33 Limited Sex-Based Differences in Viral Outcomes of ART-Treated SIV/SHIV Infection ART治疗的SIV/SHIV感染中病毒学结局的性别差异有限 Kedan Endrias and others The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1418–e1422, https://doi.org/10.1093/infdis/jiag064 34 Mitochondrial Haplogroups and Left Ventricular Diastolic Dysfunction in People Living With and Without HIV 线粒体单倍群与HIV感染者及非感染者的左心室舒张功能障碍 Craig Cronin and others The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1423–e1432, https://doi.org/10.1093/infdis/jiag090 Bacterial Disease Pathogenesis（细菌性疾病发病机制） 35 Cefazolin Inoculum Effect and Cefazolin Microbiological Treatment Failure in Serious Methicillin-Susceptible Staphylococcus aureus Infections: A Multicenter Retrospective Cohort Study 甲氧西林敏感金黄色葡萄球菌严重感染中头孢唑林接种效应与微生物学治疗失败：一项多中心回顾性队列研究 Mitchell A Jeffs and others The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1433–e1442, https://doi.org/10.1093/infdis/jiag199 36 Investigation of Correlates of Protection Against Gonococcal Infection by Comparative Immunoprofiling of Responses in Experimental and Clinical Studies 通过实验和临床研究中免疫反应的比较分析，探究淋球菌感染保护的相关因素 Samantha A McKeand and others The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1443–e1453, https://doi.org/10.1093/infdis/jiag216 Parasites（寄生虫） 37 Schistosoma mansoni Infections Are Associated With Fecal Calprotectin Markers of Gut Inflammation After Accounting for HIV, Hepatitis B, and Malaria 在控制HIV、乙型肝炎和疟疾因素后，曼氏血吸虫感染与肠道炎症粪便钙卫蛋白标志物相关 Lauren Wilburn and others The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1454–e1464, https://doi.org/10.1093/infdis/jiag094 38 Expelling of Plasmodium falciparum Sporozoites by Anopheles stephensi Mosquitoes During Repeated Feeding 按蚊在反复吸血过程中驱逐恶性疟原虫子孢子 Chiara Andolina and others The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1465–e1469, https://doi.org/10.1093/infdis/jiag130 39 Predicting Risk of Plasmodium Vivax Microscopy-Detected Episodes Using Serological Markers in Patients With Plasmodium falciparum Malaria: A Multicountry Diagnostic Performance Evaluation 利用血清学标志物预测恶性疟原虫疟疾患者中间日疟原虫镜检检出发作的风险：一项多国诊断效能评估 Maulina Hafidzah and others The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1470–e1479, https://doi.org/10.1093/infdis/jiag164 40 Hidden Infections, Emerging Resistance: Underdiagnosed Plasmodium vivax and Multidrug Resistance-1 (pvmdr1) Gene Amplification in the Guiana Shield 隐匿感染，耐药新兴：圭亚那盾区漏诊的间日疟原虫及多药耐药基因1（pvmdr1）基因扩增 Maria Carolina Silva de Barros Puça and others The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1480–e1489, https://doi.org/10.1093/infdis/jiag196 Fungi（真菌） 41 Treatment Monitoring and Outcome Prediction in Invasive Aspergillosis Using Immunologic Markers 利用免疫学标志物监测侵袭性曲霉病的治疗效果及预后预测 Ana Pereira and others The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1490–e1499, https://doi.org/10.1093/infdis/jiag140 42 MHC-I Upregulation and Increased Glucose Dependence Define Innate Antifungal Immune Responses to Cryptococcus neoformans MHC-I上调及葡萄糖依赖性增加是针对新型隐球菌的先天抗真菌免疫应答的特征 Ayesha S Nair and Karen L Wozniak The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1500–e1510, https://doi.org/10.1093/infdis/jiag144 Letters to the Editor（致编辑的信） 43 Infectious Disease Risk Management in Body Donation Programs 遗体捐献项目中的传染病风险管理 Brandi Schmitt and others The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1511–e1512, https://doi.org/10.1093/infdis/jiaf579 44 In Response to Schmitt et al: Data Do Not Support Exclusionary Policies 回应Schmitt等人：数据不支持排斥性政策 Sara Gianella and others The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1513–e1515, https://doi.org/10.1093/infdis/jiaf580 45 CXCR6 in the Blood Is Not the Liver: Clarifying NK-Cell “Homing” and Postcure ADCC Imprints in Acute Hepatitis C 血液中的CXCR6不等于肝脏：澄清急性丙型肝炎中NK细胞"归巢"及治愈后ADCC印迹 Anxin Wen The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1516–e1517, https://doi.org/10.1093/infdis/jiag044 46 Holding One Another in a Time of Loss and Uncertainty 在失去与不确定的时代中彼此守望 Sara Gianella The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1518–e1519, https://doi.org/10.1093/infdis/jiag110 47 Comment on “Comparative Analysis of High-Dose Dual Therapies in First-Line Helicobacter pylori Eradication: An Inverse Probability of Treatment-Weighted Multicenter Study” 评《高剂量双联方案一线根除幽门螺杆菌的比较分析：一项基于逆概率治疗加权的多中心研究》 Guofu Mao and others The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1520–e1521, https://doi.org/10.1093/infdis/jiag139 Corrections（勘误） 48 Correction to: Epidemiology and Risk Factors of Norovirus Infections Among Diarrhea Patients Admitted to Tertiary Care Hospitals in Bangladesh 勘误：孟加拉国三级医院腹泻住院患者中诺如病毒感染的流行病学及危险因素 The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Page e1522, https://doi.org/10.1093/infdis/jiag234 49 Correction to: Rickettsia rickettsii subsp californica subsp nov, the Etiologic Agent of Pacific Coast Tick Fever 勘误：立克次体加州亚种新亚种——太平洋海岸蜱传热的病原体 The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1523–e1524, https://doi.org/10.1093/infdis/jiag016 50 Correction to: Hybrid B- and T-Cell Immunity Associates With Protection Against Breakthrough Infection After Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination in Avon Longitudinal Study of Parents and Children (ALSPAC) Participants 勘误：杂合B细胞和T细胞免疫与严重急性呼吸综合征冠状病毒2疫苗接种后突破性感染的保护相关——艾文纵向父母与儿童研究（ALSPAC）参与者分析 The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Page e1525, https://doi.org/10.1093/infdis/jiag161

2026-06-18

·药创新

GSK，把增长曲线交给BD

为400亿英镑营收蓄力。撰文丨蜉蝣 2026年初，GSK完成换帅。 Luke Miels接替Emma Walmsley，成为GSK的新任CEO。Miels不是陌生面孔。他曾在阿斯利康、辉瑞任职，之后长期负责GSK商业运营。接手GSK时，他的任务很明确：在2025年近327亿英镑营收基础上，带领GSK实现2031年超过400亿英镑的营收目标。 400亿营收并不轻松，好在GSK底盘够厚，HIV在增长，呼吸免疫板块也有Nucala（美泊利珠单抗）、Benlysta（贝利尤单抗）这样的成熟资产。但多替拉韦核心专利将于2028年到期，疫苗业务和肿瘤板块增长也受多种因素影响，GSK需要更多能承接2030年前后收入的资产。 Miels上任后，GSK的BD节奏明显加快。2026年以来，GSK达成10笔BD（含收购），潜在交易金额超过180亿美元（表1）。GSK试图用外部资产重塑增长曲线，为2031年400亿英镑营收目标提前蓄力。 400亿难追 GSK目前并不缺现金流。HIV仍是其最强的业务之一。2025年，GSK HIV业务收入达到76.87亿英镑，同比增长11%。其中，Dovato（多替拉韦+拉米夫定）销售额为26.78亿英镑，同比增长22%；Cabenuva（卡替拉韦+利匹韦林）销售额为14.02亿英镑，增长了42%；Apretude（长效卡替拉韦）销售额为4.39亿英镑，同比增长62%。Dovato仍在放量，Cabenuva和Apretude两款长效注射产品也在接力。但受2028年专利到期压力，留给GSK切换产品结构的时间不多。因此，HIV板块很难单独承担GSK的营收增量压力。另一方面，GSK的疫苗业务很稳定，但弹性有限。 Shingrix（重组带状疱疹疫苗）是GSK的拳头产品。2025年Shingrix销售额接近36亿英镑。2017年，该产品获FDA批准上市；2019年进入中国市场。凭借90%保护效力和独家市场地位，Shingrix长期支撑GSK疫苗板块，也是GSK在成人疫苗市场的基本盘。Arexvy作为全球首款获批上市的RSV疫苗，也让GSK在RSV赛道中拿到先发位置。但疫苗业务的收入弹性不如特药。一方面，年度业绩受接种率波动、季节性因素及竞品分流影响较大；另一方面，疫苗依赖人群渗透率提升驱动增长，在目标人群接种趋于饱和后，缺乏持续放量的底层逻辑，难以维持长期高增长，增长曲线更容易见顶走平。 2025年GSK不同板块营收情况图片来源：GSK 2025年财报因此，RI&I（呼吸、免疫学与炎症治疗）被推到更靠前的位置。 2025年，GSK特药板块收入134.74亿英镑，同比增长17%。其中，RI&I同比增长18%，成为仅次于HIV的第二增长支柱。美泊利珠单抗和贝利尤单抗是该领域的代表资产。2025年这两款产品分别为GSK贡献了20.08亿英镑（+15%）和17.73亿英镑（+22%）的销售额，给RI&I提供了足够厚的收入支撑。此外，Depemokimab（德莫奇单抗）是GSK为IL-5通路准备的下一张牌。该药通过长效化设计，将给药频率降至每年两次，用更低频的给药方案延续GSK在嗜酸性粒细胞疾病中的优势。2025年12月16日，Depemokimab获得FDA批准上市，用于12岁及以上嗜酸性粒细胞表型重度哮喘患者的附加维持治疗，成为首个也是目前唯一获批用于该适应症的超长效生物制剂。 2026年3月27日，Depemokimab在国内获批上市，用于治疗重度嗜酸性粒细胞性哮喘（SEA）；一周后，该药又获批新适应症，用于治疗慢性鼻-鼻窦炎伴鼻息肉（CRSwNP）。Nucala的成功证明了IL-5通路的商业化价值，Depemokimab承担的是下一轮产品周期的延续。前期买得克制，后期重点押注专利到期及竞争加剧都在压缩GSK的时间窗口，单靠内部研发，节奏未必跟得上。Miels上任后，GSK把更多动作放到了外部BD上。2026年以来，GSK出手频率明显提高，但买入方向并未离开原有业务版图，仍然围绕RI&I、HIV和肿瘤几条主线补缺口（表1）。表1.GSK2026年BD一览数据来源：GSK官网，药创新整理 1月8日，GSK同时与Noetik和Helix达成合作，切入AI和基因组数据。Noetik合作为期五年，GSK预付5000万美元，获得其在非小细胞肺癌和结直肠癌领域虚拟细胞基础模型的使用许可。Helix合作则围绕GenoSphere队列数据展开，覆盖外显子组、基因组和纵向临床信息。这两笔合作离商业化还远，但对GSK的肿瘤研发有现实意义。GSK手里有Jemperli（多塔利单抗，PD-1）、Zejula（尼拉帕利，PARP抑制剂）、Omjjara（莫洛替尼，激酶抑制剂），也通过ADC授权补过管线，但和头部肿瘤MNC相比，资产厚度仍不算充裕。AI和基因组数据，更多用在靶点识别和适应症选择等前端环节。金额不大，但指向很明确。 1月20日，GSK连做三笔交易。最受关注的是22亿美元收购RAPT Therapeutics，获得处于IIb期临床的长效抗IgE单抗Ozureprubart。该药主攻食物过敏和慢性自发性荨麻疹（CSU），属于GSK重点加码的RI&I领域。 CSU市场已有成熟参照。奥马珠单抗（Omalizumab）长期占据主导地位，2024年销售额逼近45亿美元，但核心专利已于2025年到期。新一代抗IgE抗体的竞争正转向给药频率和效力。Ozureprubart通过每8至12周给药一次，相比Omalizumab更具有便利性优势。GSK买下RAPT，补的是一个具有明确机制和差异化优势的中期资产。同一天，GSK子公司Tesaro与韩国Alteogen达成最高2.65亿美元合作，开发PD-1抗体dostarlimab（Jemperli）的皮下注射制剂。这笔交易不增加新分子，更多服务于Jemperli的生命周期管理。此外，ViiV Healthcare股权调整也在同日披露。GSK、辉瑞、盐野义达成协议，盐野义支付21.25亿美元承接辉瑞持有的ViiV 11.7%股权。ViiV是GSK HIV业务的平台公司。对GSK而言，HIV平台的股权关系更简单，后续长效产品放量也更容易聚焦。 2-5月，GSK把BD继续推向小核酸、肺动脉高压和内脏脂肪代谢。 2月23日，GSK与前沿生物达成小核酸药物授权协议，获得两款早期siRNA候选药物的全球独家开发、生产及商业化权利。其中一款已进入IND阶段，另一款为临床前候选药物。前沿生物获得4000万美元首付款，并有资格获得最高9.63亿美元的里程碑付款。对GSK来说，这是一次偏早期的平台型补仓。 2月25日，GSK以最高9.5亿美元现金收购35Pharma。35Pharma核心资产HS235靶向activin受体信号通路，拟用于肺动脉高压以及射血分数保留型心衰相关肺动脉高压。这笔交易也被视为GSK在为GLP-1热潮之后的慢病管理提前储备弹药。 5月6日，GSK以最高10.05亿美元拿到时安生物的临床阶段管线SA030的大中华区以外全球独家权益。这是一款处于I期临床、靶向ALK7的脂肪靶向长效siRNA候选药物，核心拟开发适应症为肥胖、2型糖尿病、非酒精性脂肪肝等心脏代谢类慢病，可选择性减少内脏脂肪并保留肌肉量，后续还可拓展至肥胖相关慢性肾病、代谢性心血管并发症等适应症。合作补齐了GSK在代谢慢病赛道的差异化空白，避开GLP-1赛道激烈内卷，切入内脏脂肪调控全新机制，可与公司现有FGF21类似物等代谢管线形成协同联用潜力，同时继前沿生物siRNA项目后进一步夯实GSK在小核酸新药领域的技术布局。 6月9日，GSK终于抛出重磅并购交易。斥资106亿美元全现金收购Nuvalent，一举拿下两款已进入FDA上市审评的新一代ALK抑制剂Neladalkib、ROS1抑制剂Zidesamtinib，以及处于I期临床的HER2选择性小分子抑制剂NVL-330与全套精准激酶药物研发平台，直接补齐了公司此前在肺癌精准小分子靶向领域的重大管线空白。这次收购也大幅提升了GSK在全球肿瘤领域的行业竞争力。综合来看，GSK前期买得很“克制”，在业务承压背景下，针对核心治疗领域进行的系统补强与结构优化，并为下一阶段增长提前预留位置。在蓄势和等待中，终于在6月实现对Nuvalent的收购，重押肺癌单一大赛道。理性收缩密集BD之外，GSK也在收缩。 2月2日，GSK计划削减研发岗位，作为科学能力与战略重点对齐的一部分，预计在美国和英国影响多达350个职位。其中，英国受影响员工不到50人，美国受影响员工不到70人。虽然这次裁员规模不大，但也已经说明GSK在买资产的同时，也在清理内部资源。这类调整在MNC里并不少见。研发预算不会平均分给所有项目。低优先级项目失去预算，外部更合适的资产拿到资金。内部岗位缩减和外部BD增加并行出现，反而更接近当下大型药企的正常状态。 3月9日，GSK与Alfasigma达成许可协议。Alfasigma获得linerixibat全球独家开发、生产和商业化权益（表1）。Linerixibat是一种IBAT抑制剂，用于治疗原发性胆汁性胆管炎患者的胆汁淤积性瘙痒。该药已在美国、欧盟和日本获得孤儿药资格认定，在中国获得优先审评。GLISTEN III期试验达到主要终点和关键次要终点，显示其在胆汁淤积性瘙痒和瘙痒相关睡眠干扰方面较安慰剂有改善。根据协议，GSK将获得3亿美元首付款。3月19日，linerixibat获FDA批准上市，触发1亿美元里程碑付款。目前，linerixibat在欧盟、英国、加拿大和中国的上市申请仍在审评中；若欧盟和英国获批，GSK还将获得2000万美元里程碑付款。此外，GSK还有资格获得最高2.7亿美元销售里程碑，以及全球净销售额分级两位数特许权使用费。该交易潜在总金额最高可达6.9亿美元。 linerixibat并非失败资产，它有III期数据也有明确患者需求。GSK选择把linerixibat授权出去，主要因为肝病并不是其资源最集中的领域。GSK继续自己做，可能要投入一套并不轻的商业化资源。授权出去，则能在保留经济权益的同时，把预算留给HIV、RI&I和肿瘤。事实上，这并非GSK首次剥离非核心资产，近年来，GSK已先后出售多款非核心药物的权益，聚焦核心领域。理性收缩已成为GSK优化战略布局的重要手段。结语 2026年，GSK的打法很清晰。疫苗领域继续提供收入支撑，HIV通过ViiV股权调整稳住平台，等待长效产品继续放量；RI&I依靠Nucala、Benlysta和外部买入资产承接更高预期；肿瘤借AI模型和基因组数据提高研发效率，并重押即将商业化的Neladalkib和Zidesamtinib以增加未来收入；非核心资产linerixibat交给更合适的商业化伙伴。交易公告能给市场预期，临床和销售最终兑现成果。GSK已经把筹码分到几条线上。接下来几个财报周期，销售曲线会比BD更有说服力。 END 往期精彩内容胰腺癌突破惊现92%缓解率，合成致死受制药巨头追逐当ADC“一哥”开始交学费，中国药企能接住这个时代机遇吗？和铂医药与百图生科联手，能否开创复杂大分子AI制药新范式？

100 项与盐酸利匹韦林相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D09720 D09958	盐酸利匹韦林	J05AG05	DB08864

研发状态

批准上市

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
HIV感染	美国	Janssen Products LP	2011-05-20

未上市

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
怀孕	临床3期	美国	Janssen Scientific Affairs LLC	2009-04-09
肝炎	临床1期	美国	ViiV Healthcare Ltd.	2011-11-01
丙型肝炎	临床1期	-	Tibotec Pharmaceuticals	2010-11-01
避孕	临床1期	-	Tibotec Pharmaceuticals	2008-07-01
避孕行为	临床1期	-	Tibotec Pharmaceuticals	2008-07-01
获得性免疫缺陷综合征	临床1期	-	Tibotec Pharmaceuticals	2008-06-01

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT03635788 (LATITUDE, Pubmed) 人工标引	临床3期	HIV感染	306	Cabotegravir+rilpivirine	淵顧鹽築鹹壓艱顧醖衊(淵顧衊鹹製餘網壓積餘) = 艱網醖壓範鬱餘選觸網衊憲獵襯遞鑰衊窪醖餘 (遞顧鏇鬱顧膚鹹選糧網 ) 更多	积极	2026-02-26
				Standard care	淵顧鹽築鹹壓艱顧醖衊(淵顧衊鹹製餘網壓積餘) = 鹹艱鑰窪衊蓋網蓋鹹襯衊憲獵襯遞鑰衊窪醖餘 (遞顧鏇鬱顧膚鹹選糧網 ) 更多
NCT04542070 (SOLAR, Pubmed \| J Infect Chemother)	临床3期	HIV感染	396	Cabotegravir+rilpivirine (CAB+RPV) LA Q2M with a 1-month optional once-daily OLI of CABRPV) LA Q2M with a 1-month optional once-daily OLI of CAB+RPV	觸願襯範獵築廠選構夢(鑰範鏇選構憲鬱膚膚醖) = 範醖壓鬱範遞衊膚窪遞夢築願淵夢簾壓淵鏇蓋 (觸網襯憲鑰鹽範窪壓廠 ) 更多	积极	2025-12-01
				Bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF)	觸願襯範獵築廠選構夢(鑰範鏇選構憲鬱膚膚醖) = 蓋鑰憲膚膚鏇壓艱憲窪夢築願淵夢簾壓淵鏇蓋 (觸網襯憲鑰鹽範窪壓廠 ) 更多
NCT05917509 (VOLITION, BusinessWire) 人工标引	临床3期	HIV感染	145	Vocabria + Rekambys (cabotegravir + rilpivirine LA (CAB+RPV LA))	襯鏇獵觸壓艱鏇鹽築簾(鏇觸鹽築顧膚衊夢簾選) = 鑰網選鏇製鏇範衊積製蓋襯窪構夢範構遞網憲 (憲襯鑰壓餘鬱艱範積醖 ) 更多	积极	2025-07-14
NCT03635788 (LATITUDE \| LATITUDE, CTgov)	临床3期	HIV感染	456	Oral CAB+CAB-LA Maintenance Dose+RPV-LA Loading Dose (Step 2 Arm A: LA ART)	製膚觸築廠廠鹽憲醖鑰 = 壓鹽選構鹹襯壓廠簾廠糧夢廠蓋蓋簾艱製餘壓 (醖遞願繭醖顧網膚壓醖, 餘淵壓窪顧醖範製餘醖 ~ 壓襯構鹽構鹽衊膚廠膚) 更多	-	2025-04-24
				Standard of Care (SOC) Oral ART (Step 2 Arm B: SOC)	製膚觸築廠廠鹽憲醖鑰 = 齋顧餘鬱廠蓋夢醖餘艱糧夢廠蓋蓋簾艱製餘壓 (醖遞願繭醖顧網膚壓醖, 醖夢膚鬱淵夢夢壓醖憲 ~ 憲範構觸築襯鹽壓餘簾) 更多
NCT03497676 (IMPAACT 2017/MOCHA, Pubmed \| Lancet HIV)	临床1/2期	HIV感染	139	Long-acting Injectable Cabotegravir 600 mg + Long-acting Injectable Rilpivirine 900 mg	範窪鏇鹹觸鹹簾衊醖餘(觸積醖範網觸窪選膚糧) = 10.8% [95% CI 6.2-17.2] of all 139 participants in the evaluable analysis population had at least one adverse event of grade 3 or above by week 24 鏇鬱選網簾窪憲築壓憲 (窪簾膚衊遞鹽築鑰願鹽 ) 更多	积极	2025-03-01
NCT00799864 (PAINT, CTgov)	临床2期	HIV感染	54	Rilpivirine (Cohort 1 Adolescents: Rilpivirine 25 mg)	齋築積築獵製繭憲製憲(顧遞蓋窪獵築顧獵餘顧) = 築網顧獵艱鏇鑰淵膚醖壓襯夢範壓選衊膚膚獵 (壓鹽遞鹽觸襯夢選齋鏇, 38.0) 更多	-	2024-06-25
				Rilpivirine (Cohort 2 Children (>=25 kg): Rilpivirine 25 mg)	齋築積築獵製繭憲製憲(顧遞蓋窪獵築顧獵餘顧) = 襯襯襯憲鹽壓鬱選鏇醖壓襯夢範壓選衊膚膚獵 (壓鹽遞鹽觸襯夢選齋鏇, 52.2) 更多
NCT03497676 (IMPAACT 2017/MOCHA \| MOCHA, CTgov)	临床1/2期	HIV感染	168	Combination Antiretroviral Therapy (cART)+Long-Acting Injectable Cabotegravir (CAB LA) (Cohort 1C: CAB)	獵鑰蓋醖獵襯獵鑰鹽築 = 網顧襯獵繭積憲淵築夢淵鑰壓窪鹹選構遞鏇遞 (衊觸顧壓獵鑰醖鑰觸鬱, 遞醖簾醖醖鏇鹽襯構鬱 ~ 遞獵蓋簾鹽選齋願艱膚) 更多	-	2024-05-14
				Combination Antiretroviral Therapy (cART)+RPV (Cohort 1R: RPV)	醖齋鑰鑰蓋憲憲遞蓋夢 = 簾鏇糧鹽襯糧淵製繭獵鹹觸廠餘衊製鬱膚顧襯 (鏇醖齋衊願餘憲蓋糧艱, 選顧鬱積壓積製簾觸鬱 ~ 窪餘鹽齋鏇製選醖壓窪) 更多
NCT04012931 (CTgov)	临床2期	HIV感染	26	Rilpivirine (Rilpivirine 12.5 Milligrams (mg) (<20 kg))	糧膚築積醖蓋遞簾餘襯(醖鬱膚繭選獵衊簾襯襯) = 壓鑰糧廠鑰艱觸願顧構積窪膚壓願淵窪衊獵積 (鹹獵齋醖網鏇網繭製衊, NA) 更多	-	2024-05-02
				Rilpivirine (Rilpivirine 15 mg (<20 kg))	壓壓獵觸夢廠積衊醖膚(鹽艱簾齋糧獵膚簾憲製) = 構艱觸醖糧積窪夢鬱顧顧網顧餘獵糧繭淵醖鏇 (蓋襯壓鹽醖顧製蓋鑰艱, NA) 更多
NCT04371380 (CTgov)	临床1期	HIV感染	15	CAB (IM CAB 600 mg)	廠壓廠糧構齋襯鑰積窪(築簾壓鑰觸醖願淵積繭) = 壓壓選淵築廠廠獵糧築築製顧艱願網衊選窪膚 (積艱淵壓範膚築鏇憲憲, 66) 更多	-	2024-04-22
				RPV (IM RPV 900mg)	鏇壓鑰憲簾鹽艱醖觸窪(膚願獵糧觸齋艱構範顧) = 範齋網齋廠憲觸選淵廠積鑰襯膚鹹觸範淵築窪 (壓顧鹽鬱襯醖獵顧範鹽, 37.7) 更多
TMC278-C213 (FDA) 人工标引	临床2期	HIV感染	-	EDURANT+BR (HIV RNA ≤100,000)	廠夢網繭願醖鏇鑰壓簾(艱願觸鬱鏇鏇構鏇願淵) = 齋壓鹹遞醖遞構簾襯蓋鏇糧鹹鏇繭觸壓餘繭淵 (繭襯淵範襯積襯獵鹽夢 ) 更多	优效	2024-03-15
				EDURANT+BR (HIV RNA >100,000)	廠夢網繭願醖鏇鑰壓簾(艱願觸鬱鏇鏇構鏇願淵) = 鬱衊壓願夢遞淵膚夢範鏇糧鹹鏇繭觸壓餘繭淵 (繭襯淵範襯積襯獵鹽夢 ) 更多