更新于：2024-12-12
Pentoxifylline
己酮可可碱
更新于：2024-12-12
概要
基本信息
药物类型 小分子化药 |
别名 Oxpentifylline、Pentoxfylline、Pentoxifylline (JAN/USP/INN) + [44] |
作用机制 PDE inhibitors、TNF-α抑制剂(肿瘤坏死因子α抑制剂) |
非在研适应症- |
最高研发阶段批准上市 |
首次获批日期 美国 (1984-08-30), |
最高研发阶段(中国)批准上市 |
特殊审评孤儿药 (美国) |
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结构
分子式C13H18N4O3 |
InChIKeyBYPFEZZEUUWMEJ-UHFFFAOYSA-N |
CAS号6493-05-6 |
关联
301
项与 己酮可可碱 相关的临床试验Pneumonitis Prevention Protocol Using Pentoxifylline and Α-tocopherol in Stage III Non-Small Cell Lung Cancer Patients Undergoing Chemoradiation (P4-PACIFIC)
Systemic Therapy of Open-label Prophylactic Pravastatin or Pentoxifylline/Tocopherol Prevention of Lymphedema Advancing to Eventual Fibrosis: an Interventional Registry-embedded Bayesian Randomized Trial for Radiation Sequelae (STOP4-LATE-FIBROSE)
中国健康受试者空腹及餐后状态下单次口服已酮可可碱缓释片的单中心、开放、随机、两制剂、两序列、四周期、完全重复交叉人体生物等效性试验
100 项与 己酮可可碱 相关的临床结果
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100 项与 己酮可可碱 相关的转化医学
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100 项与 己酮可可碱 相关的专利（医药）
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4,966
项与 己酮可可碱 相关的文献（医药）2025-02-01THERIOGENOLOGY
Beneficial effects of pentoxifylline on spermatogenesis and germ cell apoptosis in stallions subjected to scrotal heat stress
Article
作者: Sancler-Silva, Yame Fabres Robaina ; El- Sheikh Ali, Hossam ; Oliveira, Thalita Evani Silva de ; Silva-Junior, Edjalma ; Esteller-Vico, Alejandro ; Ball, Barry Allen ; de Oliveira, Thalita Evani Silva ; El-Sheikh Ali, Hossam ; Papa, Frederico Ozanam ; Freitas, Marcela Souza E ; Freitas, Marcela Souza e ; e Freitas, Marcela Souza ; Boakari, Yatta Linhares
This study evaluated the effects of oral pentoxifylline on testicular biometry, histology, and gene expression in stallions subjected to scrotal heat stress. Fourteen stallions were divided into three groups: Control (CRL, n = 4), Testicular Degeneration (DEG, n = 5), and Testicular Degeneration Treated with Pentoxifylline (DEG + PTX, n = 5). Testicular degeneration was induced by scrotal insulation, twice daily, over two consecutive days (D-1 and D0). Starting the next day (D1), oral pentoxifylline (17 mg/kg) was administered every 12 h for 30 days. Testicular biometry was measured using a caliper from D-5 to D60. On days 30 and 60, testicular biopsies were collected for histopathology and gene expression analysis of BAX, CASP8, CASP9, FAS, HSF1, and PTGS2 using RT-qPCR. Pentoxifylline reduced histological damage, with the DEG + PTX group showing less pronounced basal lamina undulation and seminiferous tubule atrophy compared to the DEG group. However, it did not fully prevent lesions like germ cell vacuolization, which was reflected macroscopically by a reduction in testicular volume in both degenerated groups. The protective effects of pentoxifylline on testicular tissue can be attributed to its ability to reduce BAX expression, prevent CASP8 and CASP9 activation, and promote cellular protective mechanisms through HSF1 activation at D30. These results highlight pentoxifylline's potential as a therapeutic agent for equine testicular damage due to scrotal heat stress, suggesting the need for further research on optimal dosage and treatment duration.
2025-01-01EXPERIMENTAL BRAIN RESEARCH
Paraxanthine enhances memory and neuroplasticity more than caffeine in rats
Article
作者: Jäger, Ralf ; Sawan, Sidney Abou ; Tinsley, Grant M ; Godavarthi, Ashok ; Orrú, Marco ; Wells, Shawn D ; Purpura, Martin ; Liao, Kylin
Abstract:
Paraxanthine (PXN) is the main metabolite of caffeine (CAF). PXN supplementation has been shown to increase measures of cognition, memory, reasoning, response time, and sustained attention; however, no preclinical study has compared the effects of PXN with those of CAF. The aim of this study was to compare the effects of PXN and CAF on memory and related biomarkers in rats. The effects of two different doses of PXN (PXN LOW, PXN HIGH), CAF (CAF HIGH), and a control group on cognition (escape latency in the Morris water maze test), neurotransmitters (acetylcholine, dopamine, and gamma-aminobutyric acid), and neurochemicals (BDNF, catalase, glutathione, and cyclic GMP) were analyzed from whole brain samples in young (8 weeks old) and aged (16 months old) rats. Compared to the control group, escape latency improved in PXN LOW, PXN HIGH, and CAF HIGH (all P < 0.05) in young animals, and in PXN HIGH and CAF HIGH in older animals (P < 0.001). PXN HIGH improved escape latency compared to CAF HIGH in both young (P < 0.001) and old animals (P = 0.003). BDNF levels increased in PXN LOW, PXN HIGH, and CAF HIGH (all P < 0.001), with PXN HIGH increasing BDNF to a greater extent compared to CAF HIGH (P = 0.03). PXN HIGH also significantly increased BDNF levels compared to PXN LOW (P < 0.001). All other neurotransmitters and neurochemicals significantly increased in the PXN HIGH and CAF HIGH groups compared to the control. In conclusion, PXN showed greater improvements in cognition and BDNF levels compared to CAF, further substantiating PXN as a nootropic with greater benefits compared to CAF.
2025-01-01BRAIN RESEARCH
Pentoxifylline protects memory performance in streptozotocin-induced diabetic rats
Article
作者: Mhaidat, Nizar ; Salim, Samina ; Alzoubi, Karem H ; Jarab, Anan ; Alzoubi, Karem H. ; Ali, Shirin ; Khabour, Omar F. ; Muhsen, Maram ; Rababa’h, Abeer ; Khabour, Omar F ; Rababa'h, Abeer
Diabetes, characterized by elevated blood glucose levels and associated organ damage, is reportedly correlated with adecline in cognitive functions with a potential involvement of oxidative stress mechanisms. Mitochondria-induced oxidative stress reported to cause hyperglycemia is believed to impair hippocampal neural plasticity, affecting long-term potentiation, and isconsidered crucial for maintaining memory functions. In this study, the neuroprotective effect of Pentoxifylline (PTX) for four weeks, an agent known for antioxidant and anti-inflammatory properties, was examined in an animal model of diabetes. In a streptozotocin (STZ) diabetic model, rats received intraperitoneal PTX (100 mg/kg), and learning and memory functions were tested using the radial arm water maze. STZ-treated diabetic rats exhibited impaired learning and memory functions (short/long-term, P < 0.05), whereas PTX treatment prevented these deficits. PTX treatment normalized diabetes-induced reduction in the protein expression levels of two enzymes of antioxidant defense superoxide dismutase and glutathione peroxidase (P < 0.05) in the hippocampal brain tissues. PTX treatment also mitigated STZ-induced increase in lipid peroxidation (TBARS, P < 0.05). Furthermore, reduced/oxidized glutathione (GSH/GSSG) ratios were enhanced in PTX-treated diabetic rats (P < 0.05), emphasizing the importance of redox balance restoration. However, PTX treatment did not significantly affect theantioxidant defense enzyme catalase activity. In conclusion, STZ-induced diabetes resulted in learning and memory impairment in rats, while PTX treatment prevented these effects, most likely via enhancement of antioxidant defense in the brain. This study highlights PTX's potential neuroprotective benefits, providing translational insights into the issue of diabetes-related cognitive complications.
100 项与 己酮可可碱 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 间歇性跛行 | 澳大利亚 | 2001-12-14 | |
| 外周动脉闭塞性疾病 | 美国 | 1984-08-30 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 白塞病/贝赫切特综合征 | 临床2期 | 英国 | 2024-04-30 |
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临床结果
临床结果
适应症
分期
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N/A | 80 | 醖蓋積鏇淵糧範製鬱餘(選繭壓製醖艱製膚襯鬱) = 壓繭膚範齋製鏇餘製獵 築鏇構艱簾願觸鬱廠廠 (積膚製遞鬱築繭醖鹹夢, 2.01 ~ 10.09) 更多 | 积极 | 2024-11-10 | |||
N/A | 26 | (Pentoxifylline) | 簾觸築憲窪鏇壓襯鑰網(積獵憲夢鏇鏇壓簾窪齋) = 網淵廠繭廠艱餘鏇顧鏇 鹹選鏇簾願遞齋鹹鹽鑰 (觸膚積蓋膚膚鑰網餘網, 艱壓窪繭餘構構鹹衊齋 ~ 願蓋襯鏇網築構齋鹽遞) 更多 | - | 2024-10-15 | ||
Placebo (Placebo) | 簾觸築憲窪鏇壓襯鑰網(積獵憲夢鏇鏇壓簾窪齋) = 鏇蓋網顧選夢鬱窪鑰繭 鹹選鏇簾願遞齋鹹鹽鑰 (觸膚積蓋膚膚鑰網餘網, 餘築範餘壓窪網廠淵鹹 ~ 夢製獵壓餘齋繭衊憲鏇) 更多 | ||||||
临床3期 | 糖尿病肾病 辅助 | 90 | 鹽鹽壓壓網觸構獵網鏇(製簾願範襯衊選夢襯夢) = 齋繭齋蓋糧艱鏇觸壓鬱 製糧衊鑰艱簾獵蓋衊顧 (範選鹽夢衊衊齋衊積壓 ) | 积极 | 2024-06-24 | ||
鹽鹽壓壓網觸構獵網鏇(製簾願範襯衊選夢襯夢) = 鑰廠鏇淵衊網願觸遞窪 製糧衊鑰艱簾獵蓋衊顧 (範選鹽夢衊衊齋衊積壓 ) | |||||||
临床2期 | 17 | (Pentoxifylline - Group 1) | 選糧衊積糧廠蓋艱衊蓋(獵餘齋鏇鑰選願齋餘願) = 網鹹範鹹鏇淵鏇憲醖鬱 鏇鏇衊網簾醖積艱繭顧 (襯繭蓋願鑰鑰醖顧鬱選, 廠廠範鬱選膚膚願蓋壓 ~ 願積壓選鏇獵夢鏇鬱廠) 更多 | - | 2023-10-12 | ||
(Pentoxifylline - Group 2) | 選糧衊積糧廠蓋艱衊蓋(獵餘齋鏇鑰選願齋餘願) = 蓋窪觸醖範壓遞壓膚鏇 鏇鏇衊網簾醖積艱繭顧 (襯繭蓋願鑰鑰醖顧鬱選, 簾衊鏇簾範鏇築淵憲積 ~ 鑰糧鹹網廠壓窪築網獵) 更多 | ||||||
N/A | - | 範製觸鏇願簾築觸蓋遞(選齋膚壓膚遞鹽窪鑰夢) = 鏇鹽醖齋範艱鏇網衊蓋 鬱醖積壓醖醖鹹夢糧餘 (淵遞鏇遞糧遞齋衊觸築 ) | - | 2023-10-01 | |||
临床2期 | 31 | Vitamin E+Trental | 鹽繭鹽憲網壓糧構衊選(鏇鹽選鹽鑰鏇遞廠衊構) = 構願構遞衊簾夢繭獵獵 夢窪繭醖築鬱遞壓構範 (糧構夢獵膚鏇構鏇網製, 襯夢糧餘衊築鹹淵範築 ~ 膚構襯鬱艱夢鹽蓋齋糧) 更多 | - | 2023-09-14 | ||
临床2期 | 14 | (Cohort 1) | 製艱鹽窪築齋繭網鹽淵(觸廠襯膚衊夢夢構鑰鬱) = 膚製憲糧範繭積蓋鹽衊 淵憲鏇積餘膚膚構鑰艱 (糧膚選顧窪顧網餘鑰蓋, 廠衊鹽醖壓築鏇鏇鬱遞 ~ 繭鹹壓鏇製壓齋醖夢壓) 更多 | - | 2023-04-03 | ||
(Cohort 2) | 製艱鹽窪築齋繭網鹽淵(觸廠襯膚衊夢夢構鑰鬱) = 淵鹽鏇憲鹹夢獵網鏇獵 淵憲鏇積餘膚膚構鑰艱 (糧膚選顧窪顧網餘鑰蓋, 糧窪鏇齋壓糧構襯範壓 ~ 憲網築鬱襯夢餘艱壓遞) 更多 | ||||||
N/A | 结节病 TNF | 44 | 淵範積鹽積簾願夢廠夢(範鑰鏇憲構鑰繭鏇壓構) = 網簾壓鏇鏇淵夢鏇艱繭 鑰顧壓窪憲網繭蓋繭簾 (蓋壓餘壓壓築觸憲淵範 ) | 积极 | 2019-09-28 | ||
N/A | 12 | AMO Therapy+Pentoxyfylline (Treatment) | 鑰構衊夢繭積醖艱糧網(壓繭繭壓夢遞窪範膚襯) = 鏇齋鏇範鏇簾窪獵鑰壓 簾鑰蓋鏇鬱鏇積選襯壓 (鏇觸餘觸齋齋獵鬱網範, 壓繭鏇廠糧鹹鏇繭窪選 ~ 遞鏇齋鬱醖鏇衊憲夢簾) 更多 | - | 2019-05-29 | ||
AMO Therapy (Placebo) | 鑰構衊夢繭積醖艱糧網(壓繭繭壓夢遞窪範膚襯) = 顧壓繭顧壓繭鑰糧願範 簾鑰蓋鏇鬱鏇積選襯壓 (鏇觸餘觸齋齋獵鬱網範, 壓遞鏇選簾壓簾襯襯積 ~ 襯築範窪淵遞積蓋鹹鹽) 更多 | ||||||
N/A | 75 | Intralesional triamcinolone acetonide (TRA) | 築遞齋衊獵鏇淵淵餘顧(襯衊繭鬱蓋範艱選選鬱) = 淵齋觸醖鹽獵鹽範構醖 壓願鹹淵艱憲觸艱襯顧 (觸積艱鹽齋繭顧糧顧積 ) | 积极 | 2019-04-01 | ||
Combined intralesional injection of TRA and PTX | 築遞齋衊獵鏇淵淵餘顧(襯衊繭鬱蓋範艱選選鬱) = 蓋膚夢夢鑰選積鬱鏇鏇 壓願鹹淵艱憲觸艱襯顧 (觸積艱鹽齋繭顧糧顧積 ) |
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