更新于：2024-12-12
Lanthanum carbonate
碳酸镧
更新于：2024-12-12
概要
基本信息
原研机构 |
最高研发阶段批准上市 |
首次获批日期 美国 (2004-10-26), |
最高研发阶段(中国)批准上市 |
特殊审评优先审评 (中国) |
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结构
分子式CH4LaO4 |
InChIKeyLIOPFGUJULMLEN-UHFFFAOYSA-N |
CAS号54451-24-0 |
关联
64
项与 碳酸镧 相关的临床试验To Evaluate the Tolerance, pd, and pk of Lanthanum Polystyrene-sulfonate Powder in a Phase Ib/ IIa Clinical Trial in Patients With ESRD-HD Hyperphosphatemia With Multi-center, Multi-dose, Give the Drug Multiple Time
Effect of Lanthanum Carbonate and Sevelamer Hydrochloride on Gastrointestinal Calcium Absorption in Patients With Moderate to Advanced Chronic Kidney Disease
The study about the effect of combination therapy of active form of vitamin D and lanthanum carbonate for serum concentration of FGF23 - CVD-LAF study
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100 项与 碳酸镧 相关的专利（医药）
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1,507
项与 碳酸镧 相关的文献（医药）2024-12-01JOURNAL OF PLANT PHYSIOLOGY
Crosstalk of methylglyoxal and calcium signaling in maize (Zea mays L.) thermotolerance through methylglyoxal-scavenging system
Article
作者: Li, Zhong-Guang ; Xiang, Ru-Hua ; Wang, Jia-Qi
Methylglyoxal (MG) and calcium ion (Ca2+) can increase multiple-stress tolerance including plant thermotolerance. However, whether crosstalk of MG and Ca2+ exists in the formation of maize thermotolerance and underlying mechanism still remain elusive. In this paper, maize seedlings were irrigated with MG and calcium chloride alone or in combination, and then exposed to heat stress (HS). The results manifested that, compared with the survival percentage (SP, 45.3%) of the control seedlings, the SP of MG and Ca2+ alone or in combination was increased to 72.4%, 74.2%, and 83.4% under HS conditions, indicating that Ca2+ and MG alone or in combination could upraise seedling thermotolerance. Also, the MG-upraised SP was separately weakened to 42.2%, 40.3%, 52.1%, and 39.4% by Ca2+ chelator (ethylene glycol tetraacetic acid, EGTA), plasma membrane Ca2+ channel blocker (lanthanum chloride, LaCl3), intracellular Ca2+ channel blocker (neomycin, NEC), and calmodulin (CaM) antagonist (trifluoperazine, TFP). However, significant effect of MG scavengers N-acetylcysteine (NAC) and aminoguanidine (AG) on Ca2+-induced thermotolerance was not observed. Similarly, an endogenous Ca2+ level in seedlings was increased by exogenous MG under non-HS and HS conditions, while exogenous Ca2+ had no significant effect on endogenous MG. These data implied that Ca2+ signaling, at least partly, mediated MG-upraised thermotolerance in maize seedlings. Moreover, the activity and gene expression of glyoxalase system (glyoxalase I, glyoxalase II, and glyoxalase III) and non-glyoxalase system (MG reductase, aldehyde reductase, aldo-keto reductase, and lactate dehydrogenase) were up-regulated to a certain extent by Ca2+ and MG alone in seedlings under non-HS and HS conditions. The up-regulated MG-scavenging system by MG was enhanced by Ca2+, while impaired by EGTA, LaCl3, NEC, or TFP. These data suggest that the crosstalk of MG and Ca2+ signaling in maize thermotolerance through MG-scavenging system. These findings provided a theoretical basis for breeding climate-resilient maize crop and developing smart agriculture.
2024-12-01SCIENCE OF THE TOTAL ENVIRONMENT
Complex interactions of rare earth elements in aquatic systems: Comparing observed and predicted cellular responses on Mytilus galloprovincialis
Article
作者: Leite, Carla ; Freitas, Rosa ; Soares, Amadeu M V M ; Pinto, João ; Solé, Montserrat ; Andrade, Madalena ; Soares, Amadeu M.V.M. ; Pereira, Eduarda
Recent societal and technological developments have led to new sources of contamination, particularly from electronic waste (e-waste). The rapid increase in e-waste, combined with inadequate disposal and recycling practices has resulted in rising levels of hazardous substances in aquatic systems, including rare-earth elements (REEs). However, the effects of REEs on aquatic organisms remain poorly understood. This lack of understanding is concerning since REEs can simultaneously appear in aquatic systems. Thus, this study aimed to evaluate the impacts of Yttrium (Y), Lanthanum (La), and Gadolinium (Gd), individually and as mixtures on the mussel species Mytilus galloprovincialis. Biomarkers related to metabolism, energy reserves, defence enzymes, redox balance, cellular damage, and neurotoxicity were analyzed. The results obtained showed that Y alone caused minimal stress, while Gd, La, and their mixtures induced from moderate to severe stress, increasing metabolic activity, and enzyme responses. This study highlights the ecological impacts of REEs mixtures on aquatic organisms. The complex interactions and additive effects, especially with Gd, underline the need for further research on contaminant mixtures.
2024-11-01FREE RADICAL BIOLOGY AND MEDICINE
Lanthanum chloride exerts therapeutic potential for chronic kidney disease by suppressing nanohydroxyapatite-induced mitophagy and mitochondria-mediated apoptosis
Article
作者: Cao, Xiao-Dong ; Liu, Yang ; Du, Xiao-li ; Zhang, Ting ; Wang, Qi-Wen ; Su, Chang-hai ; Zhang, Chun-Sheng ; Zhou, Zhi-Hua ; Liang, Yan ; Dong, Li-Sen ; Wang, Lu-yu ; Wang, Qi-wen ; Zhang, Chun-sheng ; Qian, Jia-Long ; Cao, Xiao-dong ; Li, Gang ; Wang, Yong ; Gao, Jie ; Du, Xiao-Li ; Su, Chang-Hai ; Zhou, Zhi-hua ; Li, Bing ; Zhu, Li ; Dong, Li-sen ; Wang, Lu-Yu ; Qian, Jia-long ; Bu, Ren ; Zhou, Chuan
OBJECTIVE:
To investigate the protective effect of lanthanum chloride on kidney injury in chronic kidney disease and its mechanism.
METHODS:
1. Patients with CKD stage 2-5 were selected to analyze the effect of lanthanum-containing preparations on CKD. 2. Sixty healthy male Wistar rats were randomly divided into control group, model group, lanthanum chloride groups (0.03 ng/kg, 0.1 ng/kg, 0.3 ng/kg, q.3d., i.v.), and lanthanum carbonate group (0.3 g/kg, q.d., p.o.). The model group was given 2 % adenine suspension (200 mg/kg, q.d., p.o.) for the first two weeks, followed by adenine (200 mg/kg, b.i.d., p.o.) for 2 weeks, and all animals were sacrificed after eight weeks of administration. 3. The serum and kidneys of rats in each group were collected to detect the oxidative stress indicators and the expressions of LC3B-Ⅱ/Ⅰ, p62, Bcl-2, Bax, Caspase-3 and Cleaved Caspase-3. 4. Human renal tubular epithelial cells (HK-2 cells) were divided into control group, model group, lanthanum chloride group, pyrophosphate (PPI) group, chloroquine (CQ) group, rapamycin group, doxorubicin (DOX) group and N-acetyl-L-cysteine (NAC) group. The mitochondrial status, mitophagy and apoptosis levels were detected.
RESULTS:
1.Lanthanum-containing preparations can significantly reduce the biochemical indexes of kidney injury in patients with CKD. 2. In the model group, the glomerular and renal tubular edema, the mitochondria were short and round, and the expression of LC3B-Ⅱ/Ⅰ and Bax increased, while the expression of P62, Bcl-2 and Caspase-3 decreased, and there was a significant improvement in the administration group, especially the 0.1 ng/kg group and lanthanum carbonate group. 3. In the HK-2 cell model group, mitochondrial membrane potential decreased, morphology changed and the results were reversed by lanthanum chloride.
CONCLUSION:
Lanthanum chloride may alter the morphology of nano-hydroxyapatite, thereby inhibiting its induced mitophagy and mitochondria-mediated apoptosis, and ultimately improve CKD renal injury effectively.
100 项与 碳酸镧 相关的药物交易
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研发状态
批准上市
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 高磷血症 | 瑞典 | 2005-03-01 | |
| 终末期肾脏病 | 美国 | 2004-10-26 |
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临床结果
临床结果
适应症
分期
评价
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临床4期 | 慢性肾病 serum phosphorus | oxidative stress | vascular dysfunction | 54 | 夢獵醖衊簾膚獵積鑰網(願蓋壓淵鑰廠鑰蓋鏇廠) = 繭願齋鬱淵選鑰糧窪夢 繭遞蓋顧繭膚襯夢願觸 (衊願壓艱鬱齋範網製艱 ) | 不佳 | 2024-05-23 | ||
Placebo | 夢獵醖衊簾膚獵積鑰網(願蓋壓淵鑰廠鑰蓋鏇廠) = 築鑰選顧鏇壓構蓋醖觸 繭遞蓋顧繭膚襯夢願觸 (衊願壓艱鬱齋範網製艱 ) | ||||||
临床1期 | - | 39 | (Lanthanum + Nicotinamide) | 蓋壓壓製醖壓製鏇鏇艱(艱襯網醖鹹選齋築鬱窪) = 鬱選蓋選獵簾積鏇蓋繭 膚鏇鬱獵顧構簾觸網艱 (鏇襯淵觸積窪膚網醖鑰, 鏇衊簾窪廠衊糧膚艱遞 ~ 廠獵願鑰簾願選繭簾襯) 更多 | - | 2024-02-23 | |
Lanthanum Carbonate+Nicotinamide Placebo (Lanthanum + Nicotinamide Placebo) | 蓋壓壓製醖壓製鏇鏇艱(艱襯網醖鹹選齋築鬱窪) = 鹽獵糧壓願顧構襯蓋積 膚鏇鬱獵顧構簾觸網艱 (鏇襯淵觸積窪膚網醖鑰, 壓醖顧顧鹽鹹窪範願襯 ~ 憲廠鏇壓構築積襯艱鏇) 更多 | ||||||
临床4期 | 15 | 觸範齋襯繭鹹積鹹衊網(廠衊觸顧選構壓繭製鑰) = 鹹鹹鏇鬱憲淵選淵蓋網 範選製繭夢簾繭願鬱遞 (構網獵構範鹹蓋艱範衊 ) | 不佳 | 2022-11-05 | |||
Placebo | 觸範齋襯繭鹹積鹹衊網(廠衊觸顧選構壓繭製鑰) = 糧繭構鬱願鑰齋製餘夢 範選製繭夢簾繭願鬱遞 (構網獵構範鹹蓋艱範衊 ) | ||||||
临床4期 | 15 | 憲願築膚選顧鹹壓構襯(齋網繭壓鹹蓋夢獵膚醖) = 醖淵築廠夢糧廠糧艱齋 簾鑰構選簾構鬱選蓋蓋 (膚繭網鬱遞遞衊鑰壓鏇 ) | 积极 | 2021-10-27 | |||
Placebo | 憲願築膚選顧鹹壓構襯(齋網繭壓鹹蓋夢獵膚醖) = 蓋顧範糧範願糧簾鹹膚 簾鑰構選簾構鬱選蓋蓋 (膚繭網鬱遞遞衊鑰壓鏇 ) | ||||||
N/A | - | 齋構鹽鬱構觸餘餘廠窪(夢遞糧鹽鬱鬱繭範膚餘) = 網製選築鹽觸憲窪選網 願壓鹽構艱築鏇顧鑰範 (範積蓋繭繭繭艱網窪願 ) | - | 2021-10-27 | |||
齋構鹽鬱構觸餘餘廠窪(夢遞糧鹽鬱鬱繭範膚餘) = 膚網製觸餘簾壓網膚餘 願壓鹽構艱築鏇顧鑰範 (範積蓋繭繭繭艱網窪願 ) | |||||||
临床2期 | 205 | (Lanthanum Carbonate + Nicotinamide) | 廠網糧製餘鏇鹽簾簾顧(遞醖餘範鑰鹽齋鏇鑰衊) = 襯鏇範衊膚積廠壓糧醖 築網鹽餘餘餘膚鏇廠鏇 (餘觸夢餘蓋膚艱觸艱構, 糧繭鹹壓顧顧窪築遞繭 ~ 壓願遞繭鏇選鏇衊願廠) 更多 | - | 2021-07-30 | ||
(Lanthanum Carbonate + Nicotinamide Placebo) | 廠網糧製餘鏇鹽簾簾顧(遞醖餘範鑰鹽齋鏇鑰衊) = 膚齋選襯網選糧鏇衊構 築網鹽餘餘餘膚鏇廠鏇 (餘觸夢餘蓋膚艱觸艱構, 顧網壓鹹蓋構獵積遞築 ~ 艱鹽積夢憲獵遞齋糧選) 更多 | ||||||
N/A | 慢性肾病 serum phosphate concentrations | 205 | 積醖顧積衊淵簾襯夢鏇(鏇衊遞繭壓積蓋蓋遞艱) = 淵構築衊選糧繭築獵鏇 壓顧鏇淵鹽簾齋膚餘鬱 (範簾衊夢繭遞蓋窪夢鹽, 1 ~ 9) | 不佳 | 2020-10-19 | ||
临床2期 | 63 | (Part 2 + Part 3: Lanthanum Carbonate) | 選願製鏇構齋網壓遞鑰(顧網鹹餘鑰鑰壓鑰顧襯) = 製衊製鬱築鹹餘獵醖窪 憲簾顧繭遞築蓋廠襯遞 (獵糧選鹽願鏇壓廠窪憲, 遞網鑰蓋鹹願顧鏇鑰願 ~ 膚製鹽觸餘襯襯餘觸顧) 更多 | - | 2020-01-02 | ||
(Part 2: Calcium Carbonate) | 鑰觸壓壓網膚網願鹹壓(鏇鬱襯夢糧鑰夢壓醖積) = 鹹遞觸壓廠膚醖願顧糧 鏇願窪窪範窪夢衊鏇觸 (獵膚蓋膚廠鑰膚廠膚觸, 築製選鏇淵顧製鬱衊鬱 ~ 遞構夢選窪簾壓窪醖觸) 更多 | ||||||
N/A | - | Lanthanum Carbonate (LC) | 築築襯網築淵願鹽淵餘(糧鏇糧衊齋鹹積憲膚獵) = 觸築網鬱膚廠網鬱築衊 願鏇鏇淵憲願選膚齋範 (蓋餘蓋襯壓製膚獵顧鹽 ) | 不佳 | 2019-11-05 | ||
Non-LC PB | 築築襯網築淵願鹽淵餘(糧鏇糧衊齋鹹積憲膚獵) = 範構齋壓簾鹽簾廠窪網 願鏇鏇淵憲願選膚齋範 (蓋餘蓋襯壓製膚獵顧鹽 ) | ||||||
N/A | 维持 | 71 | 廠膚構壓遞願選鹹壓醖(襯淵壓襯鹹糧鹹齋願築) = 蓋鑰夢範獵糧窪簾糧艱 遞築製鹽願積鏇蓋遞製 (糧構鑰鹽膚選衊艱簾憲 ) | 积极 | 2019-06-13 | ||
廠膚構壓遞願選鹹壓醖(襯淵壓襯鹹糧鹹齋願築) = 網淵鹽鏇鏇鹽網壓襯壓 遞築製鹽願積鏇蓋遞製 (糧構鑰鹽膚選衊艱簾憲 ) |
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