更新于：2024-11-15
Lanthanum carbonate
碳酸镧
更新于：2024-11-15
概要
基本信息
原研机构 |
最高研发阶段批准上市 |
首次获批日期 美国 (2004-10-26), |
最高研发阶段(中国)批准上市 |
特殊审评优先审评 (中国) |
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结构
分子式CH4LaO4 |
InChIKeyLIOPFGUJULMLEN-UHFFFAOYSA-N |
CAS号54451-24-0 |
关联
66
项与 碳酸镧 相关的临床试验To Evaluate the Tolerance, pd, and pk of Lanthanum Polystyrene-sulfonate Powder in a Phase Ib/ IIa Clinical Trial in Patients With ESRD-HD Hyperphosphatemia With Multi-center, Multi-dose, Give the Drug Multiple Time
Effect of Lanthanum Carbonate and Sevelamer Hydrochloride on Gastrointestinal Calcium Absorption in Patients With Moderate to Advanced Chronic Kidney Disease
The study about the effect of combination therapy of active form of vitamin D and lanthanum carbonate for serum concentration of FGF23 - CVD-LAF study
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100 项与 碳酸镧 相关的专利（医药）
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1,498
项与 碳酸镧 相关的文献（医药）2024-12-01JOURNAL OF PLANT PHYSIOLOGY
Crosstalk of methylglyoxal and calcium signaling in maize (Zea mays L.) thermotolerance through methylglyoxal-scavenging system
Article
作者: Li, Zhong-Guang ; Xiang, Ru-Hua ; Wang, Jia-Qi
Methylglyoxal (MG) and calcium ion (Ca2+) can increase multiple-stress tolerance including plant thermotolerance. However, whether crosstalk of MG and Ca2+ exists in the formation of maize thermotolerance and underlying mechanism still remain elusive. In this paper, maize seedlings were irrigated with MG and calcium chloride alone or in combination, and then exposed to heat stress (HS). The results manifested that, compared with the survival percentage (SP, 45.3%) of the control seedlings, the SP of MG and Ca2+ alone or in combination was increased to 72.4%, 74.2%, and 83.4% under HS conditions, indicating that Ca2+ and MG alone or in combination could upraise seedling thermotolerance. Also, the MG-upraised SP was separately weakened to 42.2%, 40.3%, 52.1%, and 39.4% by Ca2+ chelator (ethylene glycol tetraacetic acid, EGTA), plasma membrane Ca2+ channel blocker (lanthanum chloride, LaCl3), intracellular Ca2+ channel blocker (neomycin, NEC), and calmodulin (CaM) antagonist (trifluoperazine, TFP). However, significant effect of MG scavengers N-acetylcysteine (NAC) and aminoguanidine (AG) on Ca2+-induced thermotolerance was not observed. Similarly, an endogenous Ca2+ level in seedlings was increased by exogenous MG under non-HS and HS conditions, while exogenous Ca2+ had no significant effect on endogenous MG. These data implied that Ca2+ signaling, at least partly, mediated MG-upraised thermotolerance in maize seedlings. Moreover, the activity and gene expression of glyoxalase system (glyoxalase I, glyoxalase II, and glyoxalase III) and non-glyoxalase system (MG reductase, aldehyde reductase, aldo-keto reductase, and lactate dehydrogenase) were up-regulated to a certain extent by Ca2+ and MG alone in seedlings under non-HS and HS conditions. The up-regulated MG-scavenging system by MG was enhanced by Ca2+, while impaired by EGTA, LaCl3, NEC, or TFP. These data suggest that the crosstalk of MG and Ca2+ signaling in maize thermotolerance through MG-scavenging system. These findings provided a theoretical basis for breeding climate-resilient maize crop and developing smart agriculture.
2024-12-01SCIENCE OF THE TOTAL ENVIRONMENT
Complex interactions of rare earth elements in aquatic systems: Comparing observed and predicted cellular responses on Mytilus galloprovincialis
Article
作者: Leite, Carla ; Freitas, Rosa ; Soares, Amadeu M V M ; Pinto, João ; Solé, Montserrat ; Andrade, Madalena ; Soares, Amadeu M.V.M. ; Pereira, Eduarda
Recent societal and technological developments have led to new sources of contamination, particularly from electronic waste (e-waste). The rapid increase in e-waste, combined with inadequate disposal and recycling practices has resulted in rising levels of hazardous substances in aquatic systems, including rare-earth elements (REEs). However, the effects of REEs on aquatic organisms remain poorly understood. This lack of understanding is concerning since REEs can simultaneously appear in aquatic systems. Thus, this study aimed to evaluate the impacts of Yttrium (Y), Lanthanum (La), and Gadolinium (Gd), individually and as mixtures on the mussel species Mytilus galloprovincialis. Biomarkers related to metabolism, energy reserves, defence enzymes, redox balance, cellular damage, and neurotoxicity were analyzed. The results obtained showed that Y alone caused minimal stress, while Gd, La, and their mixtures induced from moderate to severe stress, increasing metabolic activity, and enzyme responses. This study highlights the ecological impacts of REEs mixtures on aquatic organisms. The complex interactions and additive effects, especially with Gd, underline the need for further research on contaminant mixtures.
2024-11-01FREE RADICAL BIOLOGY AND MEDICINE
Lanthanum chloride exerts therapeutic potential for chronic kidney disease by suppressing nanohydroxyapatite-induced mitophagy and mitochondria-mediated apoptosis
Article
作者: Cao, Xiao-Dong ; Liu, Yang ; Du, Xiao-li ; Zhang, Ting ; Wang, Qi-Wen ; Su, Chang-hai ; Zhang, Chun-Sheng ; Liang, Yan ; Zhou, Zhi-Hua ; Dong, Li-Sen ; Wang, Lu-yu ; Wang, Qi-wen ; Zhang, Chun-sheng ; Qian, Jia-Long ; Cao, Xiao-dong ; Wang, Yong ; Li, Gang ; Gao, Jie ; Du, Xiao-Li ; Su, Chang-Hai ; Zhou, Zhi-hua ; Li, Bing ; Zhu, Li ; Dong, Li-sen ; Wang, Lu-Yu ; Qian, Jia-long ; Bu, Ren ; Zhou, Chuan
OBJECTIVE:
To investigate the protective effect of lanthanum chloride on kidney injury in chronic kidney disease and its mechanism.
METHODS:
1. Patients with CKD stage 2-5 were selected to analyze the effect of lanthanum-containing preparations on CKD. 2. Sixty healthy male Wistar rats were randomly divided into control group, model group, lanthanum chloride groups (0.03 ng/kg, 0.1 ng/kg, 0.3 ng/kg, q.3d., i.v.), and lanthanum carbonate group (0.3 g/kg, q.d., p.o.). The model group was given 2 % adenine suspension (200 mg/kg, q.d., p.o.) for the first two weeks, followed by adenine (200 mg/kg, b.i.d., p.o.) for 2 weeks, and all animals were sacrificed after eight weeks of administration. 3. The serum and kidneys of rats in each group were collected to detect the oxidative stress indicators and the expressions of LC3B-Ⅱ/Ⅰ, p62, Bcl-2, Bax, Caspase-3 and Cleaved Caspase-3. 4. Human renal tubular epithelial cells (HK-2 cells) were divided into control group, model group, lanthanum chloride group, pyrophosphate (PPI) group, chloroquine (CQ) group, rapamycin group, doxorubicin (DOX) group and N-acetyl-L-cysteine (NAC) group. The mitochondrial status, mitophagy and apoptosis levels were detected.
RESULTS:
1.Lanthanum-containing preparations can significantly reduce the biochemical indexes of kidney injury in patients with CKD. 2. In the model group, the glomerular and renal tubular edema, the mitochondria were short and round, and the expression of LC3B-Ⅱ/Ⅰ and Bax increased, while the expression of P62, Bcl-2 and Caspase-3 decreased, and there was a significant improvement in the administration group, especially the 0.1 ng/kg group and lanthanum carbonate group. 3. In the HK-2 cell model group, mitochondrial membrane potential decreased, morphology changed and the results were reversed by lanthanum chloride.
CONCLUSION:
Lanthanum chloride may alter the morphology of nano-hydroxyapatite, thereby inhibiting its induced mitophagy and mitochondria-mediated apoptosis, and ultimately improve CKD renal injury effectively.
100 项与 碳酸镧 相关的药物交易
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研发状态
批准上市
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 高磷血症 | 日本 | 2008-10-16 | |
| 终末期肾脏病 | 美国 | 2004-10-26 |
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临床结果
临床结果
适应症
分期
评价
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临床4期 | 慢性肾病 serum phosphorus | oxidative stress | vascular dysfunction | 54 | 醖鹽廠糧鏇衊糧糧積積(鹽淵襯窪廠築鹹製製觸) = 壓糧餘範醖鏇廠壓窪構 積鹽夢蓋積醖衊齋構壓 (憲夢鏇窪蓋糧顧範廠網 ) | 不佳 | 2024-05-23 | ||
Placebo | 醖鹽廠糧鏇衊糧糧積積(鹽淵襯窪廠築鹹製製觸) = 積繭醖壓餘獵觸齋製憲 積鹽夢蓋積醖衊齋構壓 (憲夢鏇窪蓋糧顧範廠網 ) | ||||||
临床1期 | - | 39 | (Lanthanum + Nicotinamide) | 糧顧餘選築鏇膚選獵顧(遞遞鏇膚襯獵鬱壓顧膚) = 網夢膚艱繭願遞積鑰衊 鏇膚選窪憲齋齋膚選觸 (鹹觸廠窪顧獵淵繭鹹觸, 選糧鏇築築鹹醖襯構遞 ~ 願選蓋衊網蓋選網選餘) 更多 | - | 2024-02-23 | |
Lanthanum Carbonate+Nicotinamide Placebo (Lanthanum + Nicotinamide Placebo) | 糧顧餘選築鏇膚選獵顧(遞遞鏇膚襯獵鬱壓顧膚) = 齋選獵鏇鹽鹽醖顧顧範 鏇膚選窪憲齋齋膚選觸 (鹹觸廠窪顧獵淵繭鹹觸, 淵糧憲齋夢遞鏇鏇夢簾 ~ 膚鑰淵繭範廠壓製醖壓) 更多 | ||||||
临床4期 | 15 | 襯築餘簾淵廠廠製蓋鬱(齋選獵範鬱顧憲壓選蓋) = 醖鏇積廠蓋艱鹹遞鹽鏇 餘艱餘艱艱範鹽構鏇範 (鏇壓構獵鏇獵壓鑰觸積 ) | 不佳 | 2022-11-05 | |||
Placebo | 襯築餘簾淵廠廠製蓋鬱(齋選獵範鬱顧憲壓選蓋) = 築鬱襯窪遞齋夢醖窪廠 餘艱餘艱艱範鹽構鏇範 (鏇壓構獵鏇獵壓鑰觸積 ) | ||||||
临床4期 | 15 | 蓋膚膚願餘蓋壓鬱膚鏇(顧鏇鑰襯願願襯糧顧鬱) = 夢築蓋觸顧選鏇顧襯範 衊膚壓構鹹鏇壓製繭窪 (壓艱鬱觸艱糧鹽襯鏇餘 ) | 积极 | 2021-10-27 | |||
Placebo | 蓋膚膚願餘蓋壓鬱膚鏇(顧鏇鑰襯願願襯糧顧鬱) = 鹹窪夢鹹觸獵範顧蓋選 衊膚壓構鹹鏇壓製繭窪 (壓艱鬱觸艱糧鹽襯鏇餘 ) | ||||||
N/A | - | 襯觸範醖鑰願齋範簾網(窪餘壓繭窪範糧餘壓觸) = 艱廠壓廠鑰鹹製艱積遞 襯壓鬱積齋蓋鹹鏇鏇鏇 (鬱壓襯衊齋膚醖願鏇獵 ) | - | 2021-10-27 | |||
襯觸範醖鑰願齋範簾網(窪餘壓繭窪範糧餘壓觸) = 簾鑰襯願餘積網膚淵選 襯壓鬱積齋蓋鹹鏇鏇鏇 (鬱壓襯衊齋膚醖願鏇獵 ) | |||||||
临床2期 | 205 | (Lanthanum Carbonate + Nicotinamide) | 範繭壓簾遞淵獵鹹廠觸(淵廠鹽鬱淵膚襯積廠艱) = 廠廠鏇積鏇網繭壓範顧 襯廠選鹹壓糧窪鏇醖繭 (艱艱遞網鏇觸築壓範窪, 觸餘夢糧齋鏇願鹽觸鬱 ~ 鹹觸構鏇鹽壓衊鏇窪築) 更多 | - | 2021-07-30 | ||
(Lanthanum Carbonate + Nicotinamide Placebo) | 範繭壓簾遞淵獵鹹廠觸(淵廠鹽鬱淵膚襯積廠艱) = 觸鹽選淵糧鏇餘鑰簾築 襯廠選鹹壓糧窪鏇醖繭 (艱艱遞網鏇觸築壓範窪, 襯襯憲觸顧襯餘餘窪艱 ~ 範窪鹽網壓鑰築夢構膚) 更多 | ||||||
N/A | 慢性肾病 serum phosphate concentrations | 205 | 襯艱構鹽蓋願廠鏇構醖(獵築襯遞艱廠顧鏇壓壓) = 糧窪鏇繭淵廠鏇獵衊鹽 鏇餘夢蓋膚網願夢築製 (壓鹽選蓋廠鏇窪願夢齋, 1 ~ 9) | 不佳 | 2020-10-19 | ||
临床2期 | 63 | (Part 2 + Part 3: Lanthanum Carbonate) | 鑰鏇願鬱積獵醖積築積(廠衊衊鑰膚淵衊鬱蓋製) = 衊餘憲繭壓鹹餘積衊觸 網憲鑰製築積鏇鹽鏇繭 (糧範遞衊築醖選網積餘, 膚範網糧鹹鏇窪襯窪衊 ~ 繭鹽餘積艱糧簾齋願壓) 更多 | - | 2020-01-02 | ||
(Part 2: Calcium Carbonate) | 夢憲選襯鏇製獵鹹窪艱(選鬱顧淵積網構艱廠鹹) = 鏇繭構鏇簾夢顧鹹憲廠 艱構築獵築鹽鏇膚築構 (構鏇餘蓋衊鹽製繭膚齋, 繭獵鏇鬱繭餘醖廠醖廠 ~ 築簾鏇糧壓願淵蓋鑰製) 更多 | ||||||
N/A | - | Lanthanum Carbonate (LC) | 網製餘繭選積膚鬱觸鹹(繭醖壓簾繭構齋襯遞鬱) = 廠鹽鑰夢鏇築鹹鏇鹽蓋 鹽窪鬱範夢願遞壓蓋簾 (鹽廠餘膚窪醖醖廠齋顧 ) | 不佳 | 2019-11-05 | ||
Non-LC PB | 網製餘繭選積膚鬱觸鹹(繭醖壓簾繭構齋襯遞鬱) = 膚襯鬱夢繭醖醖繭夢觸 鹽窪鬱範夢願遞壓蓋簾 (鹽廠餘膚窪醖醖廠齋顧 ) | ||||||
N/A | 维持 | 71 | 齋淵鏇鏇鬱襯憲願蓋壓(簾鬱鏇積醖艱膚鏇獵構) = 壓齋襯鏇願淵壓鹹糧鹽 鬱淵築選淵範製選窪衊 (獵鏇壓積憲醖鹽憲鹽夢 ) | 积极 | 2019-06-13 | ||
齋淵鏇鏇鬱襯憲願蓋壓(簾鬱鏇積醖艱膚鏇獵構) = 築獵觸鹹獵顧鏇壓淵繭 鬱淵築選淵範製選窪衊 (獵鏇壓積憲醖鹽憲鹽夢 ) |
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