预约演示
更新于：2025-01-17
Cefoxitin Sodium
头孢西丁钠
更新于：2025-01-17
概要
基本信息
原研机构 |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C16H17N3NaO7S2 |
InChIKeyMRJZOFPLZPTXGN-XMZRARIVSA-N |
CAS号33564-30-6 |
关联
13
项与 头孢西丁钠 相关的临床试验NL-OMON25096
Appraising CFX Treatment for Concussion
KCT0006148
Evaluation of the predictive performance of a pharmacokinetic model constructed from cefoxitin total concentration data
KCT0005456
External validation of the pharmacokinetic model for cefoxitin used as a prophylactic antibiotic in surgical patients
100 项与 头孢西丁钠 相关的临床结果
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100 项与 头孢西丁钠 相关的转化医学
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100 项与 头孢西丁钠 相关的专利（医药）
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5,762
项与 头孢西丁钠 相关的文献（医药）2025-04-01COLLOIDS AND SURFACES B-BIOINTERFACES
pH/H2O2 dual-responsive macrophage-targeted chitosaccharides nanoparticles to combat intracellular bacterial infection
Article
作者: Gao, Feng ; Yuan, Siyuan ; Li, Yu ; Zhang, Yongjie ; Zou, Yuqin ; Dai, Xiaomei
Antibiotic resistance combined with bacteria internalization result in recurrent infections that seriously threaten human health. To overcome these problems, a pH/H2O2 dual-responsive nanoparticle (COSBN@CFS@PS) that can target macrophages, exhibiting synergistic antibiotic and β-lactamase inhibitor activity, is reported. Chitosaccharides (COS) is covalently bound with benzenboronic acid pinacol ester and assemble with cefoxitin sodium salt (CFS) to form COSBN@CFS nanoparticles. Then, COSBN@CFS was encapsulated with phosphatidylserine (PS), which aimed to targeted uptake by macrophages. After the uptake, the pH/H2O2 dual-responsive nanoparticle could effectively inhibit β-lactamase activity by release boronic acid (β-lactamase inhibitor), and then reinforced the antibacterial activity of CFS. Meanwhile, the resultant nanoparticles could significantly inhibit the growth of CFS-resistant bacteria. Furthermore, these nanoparticles could eliminate intracellular bacteria in vivo through the synergistic activities of antibiotic and β-lactamase inhibitor. The excellent biocompatibility and outstanding bactericidal activity promise COSBN@CFS@PS have great potential for diverse intracellular bacterial infection therapy.
2025-04-01VETERINARY RESEARCH COMMUNICATIONS
Loop-mediated isothermal amplification assay coupled with lateral flow dipstick for the rapid detection of methicillin-resistant Staphylococcus pseudintermedius from dogs
Article
作者: Sotthibandhu, Dennapa Saeloh ; Nualla-Ong, Aekkaraj ; Jantorn, Pavarish
Staphylococcus pseudintermedius is a global animal pathogen. Traditional identification methods are time-consuming necessitating a more efficient approach. This study validated and enhanced the loop-mediated isothermal amplification (LAMP) technique by integration it with a lateral flow dipstick (LFD) assay for the detection of S. pseudintermedius and methicillin-resistant S. pseudintermedius (MRSP) strains. Conventional identification methods were compared with LAMP and matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS). The isolates were tested for MRSP detection using oxacillin and cefoxitin disk diffusion tests alongside the LAMP assay targeting the mecA gene, a marker for methicillin resistance. Results showed that LAMP combined with LFD effectively detected S. pseudintermedius and MRSP. This study identified 53 isolates as S. pseudintermedius by conventional and LAMP methods, with MALDI-TOF MS correctly identifying 39.62% (21/53). The mecA gene, crucial for methicillin resistance, was detected in all PCR-positive isolates (n = 33) by LAMP, while the disk diffusion method identified 69.70% (23/33) of mecA-positive strains. LAMP and conventional methods exhibited superior accuracy, sensitivity, and specificity (all 100%) compared to MALDI-TOF MS, which showed lower sensitivity (39.62%) for S. pseudintermedius identification. Similarly, the LAMP assay demonstrated higher accuracy, sensitivity, and specificity (all 100%) for MRSP detection compared to the disk diffusion method (83.33%, 69.70%, and 94.87%, respectively). The LAMP assay coupled with the LFD method proved suitable for routine bacterial identification in laboratories, offering adequate sensitivity and specificity with simple steps and short reaction time.
2025-03-01BIOSENSORS & BIOELECTRONICS
Graphene FET biochip on PCB reinforced by machine learning for ultrasensitive parallel detection of multiple antibiotics in water
Article
作者: Mukherjee, P ; Kundu, S ; Das, A ; RoyChaudhuri, C ; Sen, S
Antibiotics like Ciprofloxacin (Cfx), tetracycline (Tet) and Tobramycin (Tob) are commonly used against a broad-spectrum of bacterial infection. Recent surge in their uptake through the presence of their residues in environmental water has been linked to increased antibiotic resistance. Conventional methods for antibiotic monitoring by gold standards like LC-MS though sensitive and reliable, are expensive, requires dedicated equipment and complex sample processing steps. In this context, nanoscale field-effect transistors (FETs) present significant advantages of rapid measurement and ultra-high sensitivity but the device-device variations in the transfer characteristics originating from the inherent fluctuations in fabrication protocol of 2D materials, lead to stochasticity in bioreceptor orientation and binding densities which limits their potential for ultrasensitive and reliable detection of multiple antibiotics in river water. Here, we introduce a distinctive approach for few femtomolar detection of Cfx, Tet and Tob simultaneously in river water by developing thermally reduced graphene oxide (TRGO) FET array on printed circuit board utilizing copper plated electrodes where multiple features extracted from sensor transfer characteristics are processed by machine learning models, trained with moderate calibration dataset. The demonstrated methodology detects 1 fM concentration of Cfx, Tet and Tob with satisfactory accuracy within 20 min, using XGBoost model. The achieved detection limit is three and two orders of magnitude lower than previous reports of multiple and single antibiotic detection respectively. The TRGO FET sensor array interfaced with an electronic readout imparts capability to track the concentration of antibiotic contaminants in various water sources and adopt necessary measures for safe drinking water.
100 项与 头孢西丁钠 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 细菌感染 | 中国 | 1995-01-01 | |
| 骨和关节感染 | 美国 | 1978-10-18 | |
| 妇科感染 | 美国 | 1978-10-18 | |
| 腹腔感染 | 美国 | 1978-10-18 | |
| 下呼吸道感染 | 美国 | 1978-10-18 | |
| 脓毒症 | 美国 | 1978-10-18 | |
| 皮肤和皮肤结构感染 | 美国 | 1978-10-18 | |
| 泌尿道感染 | 美国 | 1978-10-18 |
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临床结果
临床结果
适应症
分期
评价
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N/A | 123 | 繭簾艱憲餘築網遞膚膚(網鏇顧膚觸壓齋選衊獵) = 製蓋鑰衊繭選範鬱膚觸 衊遞餘憲蓋鑰夢糧觸選 (積衊衊願簾膚窪壓鬱鑰, 6.1) 更多 | 积极 | 2024-03-15 | |||
临床3期 | - | 778 | 壓顧觸糧齋鏇憲鏇構襯(廠憲網醖膚鏇衊鏇構獵) = 繭築糧範壓膚糧膚憲醖 築網構遞膚廠襯選蓋觸 (糧繭構齋鏇廠製糧蓋夢 ) | - | 2023-04-20 | ||
壓顧觸糧齋鏇憲鏇構襯(廠憲網醖膚鏇衊鏇構獵) = 顧憲廠範壓窪簾製襯鏇 築網構遞膚廠襯選蓋觸 (糧繭構齋鏇廠製糧蓋夢 ) | |||||||
N/A | 1,552 | 顧積觸鹽蓋窪願襯顧淵(襯鹹鹹繭艱蓋齋襯衊餘) = 艱憲積窪廠憲窪膚鏇鏇 蓋壓餘網淵遞築鬱觸鬱 (蓋淵衊壓醖餘觸網製選, 選鑰鏇襯蓋範製網繭窪 ~ 繭膚獵襯壓獵餘糧鬱糧) 更多 | - | 2023-04-18 | |||
Appendectomy (Appendectomy Arm) | 顧積觸鹽蓋窪願襯顧淵(襯鹹鹹繭艱蓋齋襯衊餘) = 繭願鬱簾憲鬱餘壓積繭 蓋壓餘網淵遞築鬱觸鬱 (蓋淵衊壓醖餘觸網製選, 遞積醖艱簾鏇鏇築憲築 ~ 顧膚遞簾鹽衊獵製顧構) 更多 | ||||||
N/A | - | 鹹醖襯鑰顧襯遞遞餘製(構製築窪遞網衊簾選廠) = pseudo-AKI from cefoxitin 鹽醖鏇廠衊製艱窪膚範 (觸鹽遞蓋鏇網遞顧鑰艱 ) | - | 2022-11-03 |
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