Inebilizumab-cdon

2024年11月28日，国家医保局与人力资源社会保障部发布《国家基本医疗保险、工伤保险和生育保险药品目录(2024年)》(以下简称“2024国家医保目录”)，翰森制药4款创新药续约纳入，1款合作的创新药新增适应症纳入，该目录将于2025年1月1日正式执行。 阿美乐®（甲磺酸阿美替尼片）翰森制药自主研发的中国首个原研三代表皮生长因子受体（EGFR）酪氨酸激酶抑制剂（TKI）创新药，其已获批的两项适应症均已纳入2024国家医保目录： 1. EGFR外显子19 缺失或外显子21（L858R）置换突变的局部晚期或转移性非小细胞肺癌（NSCLC）成人患者的一线治疗； 2. 既往经EGFR-TKI治疗时或治疗后出现疾病进展，并且经检测确认存在EGFR T790M突变阳性的局部晚期或转移性NSCLC成人患者的治疗。 豪森昕福®（甲磺酸氟马替尼片）翰森制药自主研发的中国首个原研新型二代Bcr-AbI TKI，用于治疗费城染色体阳性的慢性髓性白血病（Ph+ CML）慢性期成人患者。 昕越®（伊奈利珠单抗注射液）靶向CD19 B细胞消耗性抗体，用于抗水通道蛋白4（AQP4）抗体阳性的视神经脊髓炎谱系疾病（NMOSD）成人患者。 孚来美®（聚乙二醇洛塞那肽注射液）翰森制药自主研发的中国首个长效GLP-1受体激动剂，也是全球第一款PEG化长效降糖药物，用于改善成人2型糖尿病患者的血糖控制。 希维奥®（塞利尼索片）翰森制药合作的全球首个全新机制口服选择性核输出蛋白（XPO1）抑制剂，其已获批的两项适应症均已纳入2024国家医保目录，医保支付范围为： 1. 用于既往接受过治疗且对至少一种蛋白酶体抑制剂，一种免疫调节剂以及一种抗CD38单抗难治的复发或难治性多发性骨髓瘤成人患者； 2. 用于既往接受过至少2线系统性治疗的复发或难治性弥漫性大B细胞淋巴瘤（R/R DLBCL）成人患者。 翰森制药自主研发的中国首个原研三代表皮生长因子受体（EGFR）酪氨酸激酶抑制剂（TKI）创新药，其已获批的两项适应症均已纳入2024国家医保目录： 1. EGFR外显子19 缺失或外显子21（L858R）置换突变的局部晚期或转移性非小细胞肺癌（NSCLC）成人患者的一线治疗； 靶向CD19 B细胞消耗性抗体，用于抗水通道蛋白4（AQP4）抗体阳性的视神经脊髓炎谱系疾病（NMOSD）成人患者。 翰森制药合作的全球首个全新机制口服选择性核输出蛋白（XPO1）抑制剂，其已获批的两项适应症均已纳入2024国家医保目录，医保支付范围为： 1. 用于既往接受过治疗且对至少一种蛋白酶体抑制剂，一种免疫调节剂以及一种抗CD38单抗难治的复发或难治性多发性骨髓瘤成人患者； 2. 用于既往接受过至少2线系统性治疗的复发或难治性弥漫性大B细胞淋巴瘤（R/R DLBCL）成人患者。 此外，创新药圣罗莱®（培莫沙肽注射液）、恒沐®（艾米替诺福韦片）已纳入2023国家医保目录，目前尚在协议期内，协议有效期至2025年12月31日；迈灵达®（吗啉硝唑氯化钠注射液）已纳入国家医保常规目录乙类。公司已上市创新药所有适应症均位列医保目录内，有助于进一步提高各创新药在患者中的可及性和可负担性。 翰森制药始终聚焦未被满足的临床需求，探索生物科技前沿技术领域，推动医药产业高质量发展，努力将创新成果惠及更多患者。 声明： 1、翰森制药不推荐任何未获批药品使用或未获批适应症用药。 2、本新闻稿中的医疗信息仅供信息和新闻报道使用，不用于广告目的，不要将其用于医疗保健或诊断建议。 前瞻性说明 本新闻稿包含的信息可能包括与翰森制药业务和产品前景、计划、信念、预期和策略相关的前瞻性声明。这些声明是基于推测性假设的预测，并不保证未来的表现。它们受到诸如科学、商业、政治、经济、财务、法律因素以及竞争环境和社会条件等风险和不确定性的影响，这些因素很多都是翰森制药无法控制且难以预测的，因此实际结果可能与此处所述有显著差异，且过去的证券价格趋势不应作为未来行情的指导。因此，投资者在使用这些信息进行投资决策时应谨慎行事。“致力于”“预期”“相信”“预测”“意图”“预计”“可能”“将”“应该”“计划”“继续”“目标”“考虑”“估计”“指导”“潜在”“追求”以及于任何未来计划、行动或事件的讨论中使用的类似词语和术语，均表示前瞻性声明。 翰森制药不承诺或保证前瞻性信息的准确性、及时性或完整性，并且不承担更新或修订这些前瞻性声明的义务。无论是翰森制药还是其任何董事、员工或代理人，均不对任何证明不准确或无法实现的前瞻性声明负责，也不对因依赖本新闻稿中提供的信息而产生的任何损失或损害负责，包括但不限于直接、偶然、间接或惩罚性的损害。 本新闻稿中的所有信息均为发布之日的最新信息。翰森制药不承担因新发展、未来事件或其他情况而更新或修订这些信息的责任，除非法律要求。此外，翰森制药保留在任何时候未经通知对本新闻稿的全部或部分内容进行更改、更正或中断的权利。对于特别与上市公司有关的信息，公司鼓励投资者参考翰森制药（03692.HK）的公告和财务报告。

The annual meeting of the American College of Rheumatology was held this year from Nov. 14 to 19 in Washington, D.C., and attendees included rheumatology specialists, physicians, scientists, and other health professionals. The conference featured presentations focusing on the latest advances in the diagnosis and treatment of arthritis as well as other rheumatic and musculoskeletal diseases. During one presentation, Chuan-Ju Liu, Ph.D., of the Yale University School of Medicine in New Haven, Connecticut, discussed how the sodium channel Nav1.7 represents a novel and actionable target to preserve joint structure and slow osteoarthritis progression, addressing not only pain but also structural deterioration. Liu highlighted recent discoveries linking sodium channel Nav1.7 to the regulation of joint structure in osteoarthritis. He outlined how sodium channels in chondrocytes play a critical role in maintaining cartilage integrity and how targeting these channels could mitigate cartilage degeneration. "Preclinical studies demonstrated that modulating Nav1.7 can prevent joint deterioration, suggesting a promising therapeutic approach," Liu said. "Although still in the early stages, this research points toward the potential for developing sodium channel inhibitors or modulators as disease-modifying treatments for osteoarthritis. Over time, this approach may complement or reduce reliance on existing treatments like nonsteroidal anti-inflammatory drugs, which primarily address symptoms and often have side effects." Press Release In another presentation, Daniel Clauw, M.D., of the University of Michigan in Ann Arbor, discussed cannabis therapy for chronic pain among patients with rheumatic diseases. Currently, there are very few randomized clinical trials evaluating the effectiveness and safety of cannabis products. In addition, the results of these studies can vary based on dose, mode of administration, and an individual's metabolism. It is also difficult to determine how much cannabidiol (CBD) and tetrahydrocannabinol (THC) are contained within cannabis products. However, Clauw stressed that cannabis can still be a relatively safe and effective option for the treatment of chronic pain. "Cannabis products likely have a role in treating pain but more research needs to be done regarding what cannabis products work for what types of pain," Clauw said. "We know that CBD is quite safe and legal in all of the United States and people should try that before venturing to THC, which may be helpful in some but has far more potential side effects." Press Release Lihi Eder, M.D., of the Women's College Hospital and University of Toronto, discussed how understanding sex-related differences in psoriatic arthritis is critical to developing approaches that consider the sex of the patient in disease management. Male and female patients with psoriatic arthritis may present differently, with female patients having more pain and disability and a lower response to biologic therapies compared with their male counterparts. Eder said that the mechanisms behind these findings remain unclear, but the differences could be related to biological mechanisms such as pain processing, immune function, and the pharmacokinetics of drugs. They could also be due to sociocultural factors, including coping mechanisms, support systems, and access to care. "Considering sex/gender in patient care could improve outcomes. For example, use of more sensitive imaging such as ultrasound to investigate the source of pain may be more important in females and could provide insights about the cause of pain and inform therapy," Eder said. "More research is needed to identify mechanisms for the observed differences." Press Release ACR: Inebilizumab Reduces Risk for Flares in IgG4-Related Disease TUESDAY, Nov. 19, 2024 -- For patients with immunoglobulin G4-related disease, inebilizumab reduces the risk for flares and increases the likelihood of flare-free complete remission, according to a study published online Nov. 14 in the New England Journal of Medicine to coincide with the annual meeting of the American College of Rheumatology, held from Nov. 14 to 19 in Washington, D.C. Read Full Text ACR: Colchicine No Benefit for Painful Knee Osteoarthritis TUESDAY, Nov. 19, 2024 -- Colchicine fails to improve knee pain, function, or size of synovial effusions with painful knee osteoarthritis, according to a study presented at the annual meeting of the American College of Rheumatology, held from Nov. 14 to 19 in Washington, D.C. Read Full Text Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.