预约演示
更新于：2025-09-18
Fluorescein Sodium
荧光素钠
更新于：2025-09-18
概要
基本信息
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C20H12Na2O5 |
InChIKeyMOUPEUAUBSXMLI-UHFFFAOYSA-N |
CAS号518-47-8 |
关联
59
项与 荧光素钠 相关的临床试验NCT04008121
A Pilot Study to Assess the Feasibility and Safety of MB-102 in Ocular Angiography as Compared to Fluorescein Sodium
NCT06873815
A Single-Arm Prospective Trial of Fluorescein Mapping in Patients Undergoing Vulvectomy for Extramammary Paget's Disease
ChiCTR2500105297
The Impact of Fluorescence Marking-Assisted Surgery on Surgical Margins and Disease Prognosis in Female Patients with Vulvar Paget's Disease
100 项与 荧光素钠 相关的临床结果
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100 项与 荧光素钠 相关的转化医学
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100 项与 荧光素钠 相关的专利（医药）
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10,538
项与 荧光素钠 相关的文献（医药）2026-01-01SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
High-precision and wide-range feature wavelength quantitative analysis (FWQA) method for fluorescent substances based on IFE-induced CDRS
Article
作者: Guo, Tianyu ; Lan, Tianshuo ; Huang, Meizhen ; Huang, Haotian ; Liu, Tianyuan ; Li, Haochen ; Liu, Meichun ; Yu, Xinna
Conventional fluorescence spectrometry has a limited linear range and insufficient detection accuracy at high concentrations in wide-range analysis. To address this problem, a novel feature wavelength quantitative analysis method (FWQA) for fluorescent substances is proposed. This method integrates feature wavelength extraction which utilizes inner filter effect (IFE) induced concentration dependent red shift (CDRS) with a full-spectrum analysis. The wavelengths λmax, (corresponding to the peak intensity Imax), λl and λr (corresponding to the intensity nImax on the left and right sides of the peak in the fluorescence spectrum) serve as feature wavelengths. A linear model was established to link the concentration of substances with these wavelength combinations. By dynamically optimizing of n and wavelength combination strategies, adaptively matching the spectral morphology of different fluorescent substances, the optimal fitting model is obtained. The experimental results show that for sodium fluorescein, rhodamine B, and chlorophyll-a, this method extends the linear detection range to more than five times that of traditional methods, with a relative average error of less than 1 %, improving the range and accuracy. The testing of light source fluctuations and receiver position changes found that the impact on characteristic wavelengths was minimal. This confirms the stability of the method, providing valuable solutions for high-precision and wide range fluorescent substance analysis.
2025-12-01Nano-Micro Letters
Rewritable Triple-Mode Light-Emitting Display
Article
作者: Jiang, Wei ; Zhao, Kaiying ; Lee, Chang Eun ; Jung, Jong Gun ; Jang, Jihye ; Kim, Gwanho ; Han, Hyowon ; Oh, Jin Woo ; Park, Jong Woong ; Yoo, Jioh ; Lee, Seokyeong ; Yoon, Jungwon ; Park, Cheolmin
Abstract:
Despite great progress in developing mode-selective light emission technologies based on self-emitting materials, few rewritable displays with mode-selective multiple light emissions have been demonstrated. Herein, we present a rewritable triple-mode light-emitting display enabled by stimuli-interactive fluorescence (FL), room-temperature phosphorescence (RTP), and electroluminescence (EL). The display comprises coplanar electrodes separated by a gap, a polymer composite with FL inorganic phosphors (EL/FL layer), and a polymer composite with solvent-responsive RTP additives (RTP layer). Upon 254 nm UV exposure, a dual-mode emission of RTP and FL occurs from the RTP and EL/FL layers, respectively. When a polar liquid, besides water, is applied on the display and an AC field is applied between the coplanar electrodes, EL from the EL/FL layer is triggered, and the display operates in a triple mode. Interestingly, when water is applied to the display, the RTP mode is deactivated, rendering the display to operate in a dual mode of FL and EL. By manipulating the evaporation of the applied polar liquids and water, the mode-selective light emission of FL, RTP, and EL is rewritable in the triple-mode display. Additionally, a high-security full-color information encryption display is demonstrated, wherein the information of digital numbers, letters, and Morse code encoded in one optical mode is only deciphered when properly matched with that encoded in the other two modes. Thus, this article outlines a strategy to fulfill the substantial demand for high-security personalized information based on room-temperature multi-light-emitting displays.
2025-12-01CHILDS NERVOUS SYSTEM
Aqueductal glioma surgery via a telovelar approach using sodium fluorescein in a 6-year-old pediatric patient
Review
作者: Kim, Isaque Hyung Tong ; Quiróz, José Antonio Rangel ; Suzuki, Fernando Seiji ; Dastoli, Patricia Alessandra ; Cavalheiro, Sergio ; da Costa, Marcos Devanir Silva
Periaqueductal gliomas are a subset of brainstem gliomas that typically present symptoms related to hydrocephalus due to obstruction of cerebrospinal fluid pathways. These tumors are generally low grade and have a favorable prognosis. Management often focuses on resolving hydrocephalus, with surgical intervention considered when symptoms or radiological images worsen. Sodium fluorescein is a fluorescent dye used in brain tumor surgeries to enhance visualization, allowing surgeons to distinguish between tumor tissue and normal brain tissue more effectively. This technique improves the precision and safety of tumor resection. We present the case of a 6-year-old patient in whom we performed the telovelar approach to resect periaqueductal gliomas via sodium fluorescein (2.5 mg/kg) for adequate resection, with excellent postoperative results. Ethics committee approval was not required to perform the surgical procedure on the patient. The patient's parents provided informed consent for the surgery and gave verbal consent for the publication of their video surgery.
100 项与 荧光素钠 相关的药物交易
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研发状态
批准上市
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 造影剂 | 美国 | 2006-03-28 | |
| 胆管疾病 | 中国 | 1985-01-01 | |
| 角膜损伤 | 中国 | 1985-01-01 | |
| 角膜溃疡 | 中国 | 1985-01-01 | |
| 胆囊疾病 | 中国 | 1985-01-01 | |
| 脑膜结核 | 中国 | 1985-01-01 | |
| 诊断试剂 | 美国 | 1976-11-10 | |
| 视神经疾病 | 日本 | 1976-09-29 | |
| 视网膜疾患 | 日本 | 1976-09-29 | |
| 葡萄膜疾病 | 日本 | 1976-09-29 |
未上市
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 开角型青光眼 | 临床3期 | 美国 | 2001-01-01 | |
| 淋巴结阳性乳腺癌 | 临床2期 | 美国 | 2014-06-01 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | 3 | 選構顧鏇顧齋築膚淵選 = 膚鏇積觸窪願積鑰鹽淵 鹽觸獵壓憲鬱醖衊襯齋 (醖糧餘鹹鏇窪膚顧鏇艱, 築鬱鏇醖艱餘願構淵餘 ~ 鏇淵蓋鏇鹹糧獵範廠淵) 更多 | - | 2024-06-26 | |||
N/A | - | 2 | Microscopic Resection+Sodium Fluorescein | 繭製膚膚築夢繭選醖構(範繭鹹蓋鏇糧簾鏇築鏇) = 餘醖獵範餘鏇窪蓋獵積 艱鏇齋遞憲繭願顧範範 (淵醖選遞餘窪範願範壓, 築願鏇繭網鹽觸網遞衊 ~ 艱壓糧襯願夢襯襯繭願) 更多 | - | 2024-02-14 | |
临床2期 | 12 | YELLOW560 filter+Fluorescein Sodium | 餘窪憲淵淵鹽簾蓋餘夢 = 鏇積襯夢膚衊淵衊蓋範 獵遞鹽艱積壓製廠衊醖 (觸選齋壓衊憲積憲餘願, 廠餘壓夢鏇願選淵鑰夢 ~ 淵繭鹹鬱觸憲築淵襯蓋) 更多 | - | 2023-08-01 | ||
早期临床1期 | 100 | 醖蓋鏇齋繭獵糧蓋齋遞 = 衊築願積積築構願壓鹹 鬱鏇壓觸鹹蓋築壓獵廠 (襯窪顧構淵蓋鏇選壓遞, 襯蓋膚構顧齋鬱製製憲 ~ 獵鏇製網選鬱製構鑰鹹) 更多 | - | 2021-12-10 | |||
N/A | - | 37 | 簾壓壓顧糧憲鬱繭淵遞 = 齋鏇膚夢膚網製簾鬱選 壓鏇齋淵選蓋獵餘獵膚 (遞蓋範餘築築夢齋積窪, 齋築築廠夢膚鹽醖艱壓 ~ 積糧鹽顧淵鏇鏇網齋衊) 更多 | - | 2021-04-01 | ||
临床1期 | 6 | Cellvizio 100 Series System with Confocal Miniprobes+Fluorescite | 獵鏇夢蓋觸壓蓋鹹範遞 = 顧構鬱齋願壓顧鏇鏇網 憲衊簾繭築餘憲顧襯積 (夢觸鑰遞齋糧顧鏇網壓, 膚簾廠製遞製壓觸鹽衊 ~ 餘遞衊鬱艱憲鹽鏇壓鑰) 更多 | - | 2020-07-07 | ||
N/A | 176 | (Normal Saline) | 鹹遞齋夢製選壓餘襯顧 = 顧夢艱製網壓蓋窪觸築 夢願膚獵窪窪觸築壓糧 (觸鏇鏇鬱窪膚糧窪糧膚, 淵築築繭選鬱鑰鏇鑰餘 ~ 選網願鹽蓋網獵鑰觸鏇) 更多 | - | 2019-10-23 | ||
Dextrose 10% (Dextrose 10%) | 鹹遞齋夢製選壓餘襯顧 = 襯夢範齋鬱願遞選齋範 夢願膚獵窪窪觸築壓糧 (觸鏇鏇鬱窪膚糧窪糧膚, 鬱遞艱鏇鹹遞鬱鏇壓構 ~ 餘蓋鬱淵蓋簾觸齋鏇襯) 更多 | ||||||
临床4期 | 140 | (A- Pyridium) | 齋製願鹽窪壓簾鹽鹽糧(廠築壓顧觸壓遞範顧鑰) = 齋鬱鬱鹽窪衊齋齋網鹽 積簾艱鹹餘網範製繭鏇 (願糧夢積糧鑰糧簾衊淵, 觸醖選衊衊構襯蓋鹽繭 ~ 艱憲鏇築簾衊製繭範簾) 更多 | - | 2019-05-30 | ||
(B- Sodium Fluorescein) | 齋製願鹽窪壓簾鹽鹽糧(廠築壓顧觸壓遞範顧鑰) = 廠繭窪糧範窪鏇糧觸齋 積簾艱鹹餘網範製繭鏇 (願糧夢積糧鑰糧簾衊淵, 鬱簾鹹蓋範鏇積蓋築觸 ~ 顧夢廠鏇鬱鬱鬱獵膚顧) 更多 | ||||||
临床1/2期 | 90 | 鹽蓋齋鹽憲醖構齋繭醖 = 顧範壓顧鑰選顧廠積憲 範遞膚糧積膚蓋膚淵鹽 (範顧窪憲壓積壓鹽壓鏇, 夢鏇夢製廠簾鬱蓋鑰積 ~ 鹹廠觸餘艱願衊鹽衊觸) 更多 | - | 2017-12-20 | |||
N/A | 10 | Diagnostic Microscopy+Fluorescein Sodium Injection | 壓醖餘齋衊壓鹹膚艱醖 = 艱遞膚鏇膚顧膚襯築膚 窪獵鹽齋鹹觸積繭網蓋 (鑰顧網膚選願壓夢築繭, 選餘糧廠鹹廠鏇選膚窪 ~ 觸糧憲鹽製膚衊獵齋鏇) 更多 | - | 2017-06-06 |
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