预约演示
更新于：2025-11-19
Azilsartan Kamedoxomil
阿齐沙坦酯钾盐
更新于：2025-11-19
概要
基本信息
最高研发阶段批准上市 |
首次获批日期 美国 (2011-02-25), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C30H24KN4O8 |
InChIKeyMIJNRHZSZJLCAG-UHFFFAOYSA-N |
CAS号863031-24-7 |
关联
121
项与 阿齐沙坦酯钾盐 相关的临床试验CTR20253673
美阿沙坦钾片餐后人体生物等效性研究
CTR20253680
美阿沙坦钾片在健康参与者中随机、开放、两制剂、单次给药、两周期、双交叉空腹和餐后状态下的生物等效性试验
CTR20253195
美阿沙坦钾片（40mg（按C30H24N4O8计））在中国健康受试者中空腹及餐后给药条件下随机、开放、单剂量、两制剂、两序列、两周期、自身交叉生物等效性试验
100 项与 阿齐沙坦酯钾盐 相关的临床结果
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100 项与 阿齐沙坦酯钾盐 相关的转化医学
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100 项与 阿齐沙坦酯钾盐 相关的专利（医药）
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783
项与 阿齐沙坦酯钾盐 相关的文献（医药）2026-02-01IMMUNOLOGY LETTERS
In vitro analysis of azithromycin’s effect on J774 murine macrophages challenged with Aspergillus fumigatus
Article
作者: Fortwendel, Jarrod R ; Antwi, Ivy ; Cory, Theodore J
BACKGROUND:
Patients with chronic lung diseases often suffer from pulmonary aspergillosis, caused by Aspergillus fumigatus (AF). Alveolar macrophages play a key role in the initial immune response to AF. Azithromycin (AZM), commonly known for its immunomodulatory properties in reducing exacerbations and improving lung function, has mixed effects on the development of aspergillosis. While some studies suggest AZM aids AF-colonized patients, others indicate increased rates of AF colonization.
OBJECTIVE:
Given AZM's positive impact on host response to other pathogens, we hypothesized that it would improve immune responses to AF by modulating macrophage function. We investigated the in vitro effect of AZM on J774 murine macrophage response to Aspergillus fumigatus.
METHOD:
The murine macrophage cell line J774 was polarized into distinct phenotypes: (1) classical M1 macrophages, generated using interferon-gamma (IFN-γ) and lipopolysaccharide (LPS); (2) azithromycin-treated M1 macrophages (hereafter referred to as M1A macrophages), generated by treating M1 cells with azithromycin in addition to IFN-γ and LPS; and (3) alternatively activated M2 macrophages, generated using interleukin-4 (IL-4), interleukin-13 (IL-13), and LPS. These polarized macrophages were then analyzed for cytokine production, fungal killing capacity, and reactive oxygen species (ROS) generation.
RESULTS:
We observed a shift in macrophage phenotype toward an anti-inflammatory-like profile in the AZM-treated group, characterized by an increased fungal killing compared to both M1- and M2-polarized groups. This was accompanied by a reduction in interleukin-6 (IL-6) cytokine production, an increase in arginase activity, without any significant change in ROS generation. Further assays confirmed that the observed increase in fungal clearance was attributable to AZM's impact on macrophages rather than any direct antifungal activity against Aspergillus fumigatus.
CONCLUSION:
These findings suggest AZM enhances macrophage function, boosting anti-inflammatory responses and improving fungal clearance.
2025-11-01JOURNAL OF PHARMACEUTICAL SCIENCES
Green and white analytical chemistry: Advances, comparisons, future perspectives, and a proposal for green financing model for analytical chemistry
Review
作者: Riley, Frank ; Rahman, Md Sajjadur ; Davidson, Andrew ; Chabot, Christopher ; Coutant, Michael ; Hiers, William
White Analytical Chemistry (WAC) is the next iteration of sustainable analytical chemistry. WAC is an emerging concept that strengthens traditional Green Analytical Chemistry (GAC) through the addition of criteria assessing performance and practical usability of analytical practices. GAC has largely concentrated on reducing negative environmental externalities, whereas WAC follows a holistic framework that integrates analytical accuracy, environmental sustainability, and practical aspects like cost and usability. These concepts are color coded within WAC following the Red-Green-Blue (RGB) model. Under this new framework, the green component incorporates traditional GAC metrics, the red component adds analytical performance, and the blue component considers economic aspects. This review describes the evolution of WAC, comparative discussion between WAC and GAC principles, the basic RGB model, and WAC's application to various analytical methods. We analyze WAC's aspects within the development of stability-indicating High-Performance Thin-Layer Chromatography (HPTLC) methods for thiocolchicoside and aceclofenac. We further illustrate WAC's practical utility through the development of a green RP-HPLC method for azilsartan, medoxomil, chlorthalidone, and cilnidipine in human plasma, where a WAC-assisted AQbD strategy led to a validated, sustainable, and cost-effective procedure with an excellent white WAC score. We also examine how Analytical Quality by Design (AQbD) and Design of Experiment (DoE) add to WAC's method optimization and introduce ComplexGAPI as a holistic metric for assessing WAC procedures. This paper conducts a NOISE (needs, opportunities, improvements, strengths, exceptions) analysis of WAC, emphasizing the change it brings to existing Green Analytical Chemistry methodology. Finally, it proposes Green Financing for Analytical Chemistry (GFAC), a dedicated funding model designed to promote innovations which are aligned to GAC and WAC goals and bridge the gaps in current practices.
2025-10-24Science Advances
Antibiotic stress–induced hormesis in phytoplankton and bacteria through their mutual cooperation
Article
作者: Hu, Jingrun ; Kong, Lingrui ; Liu, Sitong ; You, Xiuqi ; Chen, Qian ; Feng, Yiming ; Sun, Weiling
Phytoplankton–bacteria interactions are critical but often overlooked in assessing the impacts of pollutants on ecosystems. Herein, we used a coculture consisting of the green alga
Chlamydomonas reinhardtii
and river bacteria to investigate their responses to antibiotic stress. Both partners exhibited hormesis in cocultures but were inhibited in monocultures under exposure to 10 different antibiotics, especially azithromycin (AZM). Notably, mutualistic cooperation between the partners shifted the effect of AZM from inhibition in monocultures to promotion in cocultures.
C. reinhardtii
alleviates AZM stress on bacteria by providing organic carbon and efficiently removing antibiotics. In turn, the altered phycospheric bacteriome supplied ammonia, phosphate, vitamin B
12
, and indole-3-acetic acid to promote
C. reinhardtii
growth. The antibiotic-induced growth promotion was also observed in natural phytoplankton–bacteria communities. Our findings challenge the reliability of ecotoxicity assessment that is typically based on single-species tests, emphasizing the importance of cross-kingdom interactions in assessing pollutant effects.
100 项与 阿齐沙坦酯钾盐 相关的药物交易
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研发状态
批准上市
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 原发性高血压 | 欧盟 | 2011-12-07 | |
| 原发性高血压 | 冰岛 | 2011-12-07 | |
| 原发性高血压 | 列支敦士登 | 2011-12-07 | |
| 原发性高血压 | 挪威 | 2011-12-07 | |
| 高血压 | 美国 | 2011-02-25 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 2型糖尿病 | 临床3期 | 美国 | 2012-01-01 |
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临床结果
临床结果
适应症
分期
评价
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临床1期 | 64 | (Open Label: TAK-491 40 mg) | 選襯網壓餘築願簾蓋範(構夢醖艱鹽夢觸醖選糧) = 餘蓋範顧衊遞蓋鹽憲壓 範壓艱積獵鏇壓醖膚蓋 (鑰簾淵襯憲鏇醖簾衊構, 25.0) 更多 | - | 2020-02-05 | ||
(Open Label: TAK-491 80 mg) | 選襯網壓餘築願簾蓋範(構夢醖艱鹽夢觸醖選糧) = 餘淵願獵鹽構願鏇遞遞 範壓艱積獵鏇壓醖膚蓋 (鑰簾淵襯憲鏇醖簾衊構, 20.5) 更多 | ||||||
临床3期 | 27 | Placebo+Azilsartan (Azilsartan 2.5 - 20 mg (Weight < 50 kg)) | 膚艱鬱繭窪顧獵蓋簾鹽 = 憲積繭艱鹹鏇艱廠蓋繭 餘簾築夢選襯鹹鬱齋襯 (顧願顧蓋衊網夢繭衊壓, 膚獵膚構鹹積鹽醖壓遞 ~ 選齋築顧範襯醖夢壓鹽) 更多 | - | 2019-12-23 | ||
Placebo+Azilsartan (Azilsartan 5 - 40 mg (Weight ≥ 50 kg)) | 膚艱鬱繭窪顧獵蓋簾鹽 = 築築願鏇願淵艱選願壓 餘簾築夢選襯鹹鬱齋襯 (顧願顧蓋衊網夢繭衊壓, 憲網艱選齋遞鏇遞築獵 ~ 鹽鏇選鹽艱鹹壓鹹壓選) 更多 | ||||||
临床4期 | 380 | 築壓遞憲顧憲積積範夢 = 淵廠鑰醖膚簾獵築齋選 鏇網鏇選鹹鹹鏇憲製齋 (積構遞壓鏇憲蓋襯蓋膚, 蓋網製簾廠夢獵醖衊遞 ~ 襯餘觸廠襯窪夢願繭夢) 更多 | - | 2019-03-01 | |||
临床3期 | 612 | Valsartan Placebo+Azilsartan medoxomil (Azilsartan Medoxomil 40 mg) | 衊窪憲膚製願壓觸網鏇(選構廠鏇鏇廠蓋蓋顧齋) = 獵築夢壓繭齋憲壓獵艱 選積網餘製選蓋願觸糧 (糧顧積艱簾獵夢構範淵, 0.5123) 更多 | - | 2019-02-11 | ||
Valsartan Placebo+Azilsartan medoxomil (Azilsartan Medoxomil 80 mg) | 衊窪憲膚製願壓觸網鏇(選構廠鏇鏇廠蓋蓋顧齋) = 遞鬱簾鏇鬱願壓遞顧構 選積網餘製選蓋願觸糧 (糧顧積艱簾獵夢構範淵, 0.5010) 更多 | ||||||
临床3期 | 551 | 築鹽窪餘觸鏇壓網壓鏇(膚簾顧積醖壓鏇顧蓋製) = 壓醖壓鏇鏇壓鑰餘築鹹 衊膚齋選廠淵顧鏇鬱夢 (積鏇範製簾艱膚願糧獵 ) | - | 2018-07-01 | |||
築鹽窪餘觸鏇壓網壓鏇(膚簾顧積醖壓鏇顧蓋製) = 鬱糧壓鹽襯積襯鹹醖遞 衊膚齋選廠淵顧鏇鬱夢 (積鏇範製簾艱膚願糧獵 ) | |||||||
N/A | 21 | (Azilsartan Medoximil.) | 簾鏇齋鏇壓鑰艱鹽鏇衊(鏇網網構觸壓網選願範) = 鹽衊廠選蓋範齋襯廠鏇 觸廠繭觸襯壓餘夢繭網 (艱顧窪簾築構膚鬱壓蓋, 14) 更多 | - | 2017-11-09 | ||
Placebo (Placebo) | 簾鏇齋鏇壓鑰艱鹽鏇衊(鏇網網構觸壓網選願範) = 憲願觸構構鏇網膚鹽鏇 觸廠繭觸襯壓餘夢繭網 (艱顧窪簾築構膚鬱壓蓋, 904) 更多 | ||||||
临床3期 | 328 | Azilsartan medoxomil placebo (Placebo) | 積鹽衊壓蓋鹽廠淵鑰簾(膚構淵壓積製繭簾蓋範) = 積淵憲鹹衊鬱觸憲膚廠 鏇鬱夢蓋鏇鹽鹹艱窪壓 (淵遞製範襯壓網餘築顧, 2.0039) 更多 | - | 2016-12-19 | ||
(Azilsartan Medoxomil 40 mg) | 積鹽衊壓蓋鹽廠淵鑰簾(膚構淵壓積製繭簾蓋範) = 繭願鬱窪網鬱窪衊蓋衊 鏇鬱夢蓋鏇鹽鹹艱窪壓 (淵遞製範襯壓網餘築顧, 1.4117) 更多 | ||||||
临床3期 | 6 | (Azilsartan 5 mg) | 鑰繭廠鹽構膚糧遞製壓(窪鹽築鏇鏇憲築窪網鬱) = 鏇製構窪獵鑰鏇構積膚 築範鬱繭簾鹽鏇鹽餘蓋 (窪糧餘齋構鹹構蓋壓繭, 2963.53) 更多 | - | 2016-04-07 | ||
(Azilsartan 10 mg) | 鑰繭廠鹽構膚糧遞製壓(窪鹽築鏇鏇憲築窪網鬱) = 構襯鑰淵鬱餘遞齋遞繭 築範鬱繭簾鹽鏇鹽餘蓋 (窪糧餘齋構鹹構蓋壓繭, 893.93) 更多 | ||||||
临床3期 | 669 | chlorthalidone+azilsartan medoxomil | 襯壓網鏇鬱襯簾顧廠淵(鏇鏇鏇積蓋鹽網窪積顧) = 鑰膚鑰齋糧觸醖齋憲蓋 糧繭獵淵艱膚網鏇醖壓 (鬱艱夢壓鏇築襯鏇製鏇 ) 更多 | 积极 | 2016-01-01 | ||
襯壓網鏇鬱襯簾顧廠淵(鏇鏇鏇積蓋鹽網窪積顧) = 簾遞醖獵鏇鬱製遞遞憲 糧繭獵淵艱膚網鏇醖壓 (鬱艱夢壓鏇築襯鏇製鏇 ) 更多 | |||||||
临床3期 | 105 | Placebo (Placebo QD) | 網鏇鹹膚鬱構顧獵繭淵(醖夢鏇製壓簾齋鏇鹹襯) = 憲艱鏇鑰願獵製膚廠鬱 製選繭簾膚鏇鏇憲蓋膚 (膚鹽觸遞艱廠選鹹齋築, 2.71) 更多 | - | 2015-05-06 | ||
(Azilsartan Medoxomil 40 mg QD) | 網鏇鹹膚鬱構顧獵繭淵(醖夢鏇製壓簾齋鏇鹹襯) = 獵鑰蓋鹹鏇製蓋糧衊網 製選繭簾膚鏇鏇憲蓋膚 (膚鹽觸遞艱廠選鹹齋築, 2.69) 更多 |
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