更新于：2024-12-24
Amlodipine besilate/Valsartan
苯磺酸氨氯地平/缬沙坦
更新于：2024-12-24
概要
基本信息
药物类型 小分子化药 |
别名 Amlodipine (as besylate)/Valsartan、Amlodipine /Valsartan、Amlodipine/Valsartan + [16] |
作用机制 AT1R拮抗剂(血管紧张素II-1型受体拮抗剂)、VDCCs阻滞剂(电压门控性钙通道复合体阻滞剂) |
治疗领域 |
非在研适应症- |
非在研机构 |
最高研发阶段批准上市 |
首次获批日期 欧盟 (2007-01-15), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C24H29N5O3 |
InChIKeyACWBQPMHZXGDFX-QFIPXVFZSA-N |
CAS号137862-53-4 |
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关联
102
项与 苯磺酸氨氯地平/缬沙坦 相关的临床试验Clinical Outcomes in Newly Diagnosed Hypertensive Patients with EXTOR (Fixed-Dose Combination of Amlodipine/Valsartan) in Routine Pakistani Practice.
缬沙坦氨氯地平片（I）在健康人体空腹/餐后状态下的
生物等效性试验
A Single Dose, Randomized, Open-label, Two-treatment, Four-period, Two-sequence, Replicate Crossover Bioequivalence Study of Generic Amlodipine and Valsartan Tablets 10/160 mg and Reference Product (Exforge® 10/160 mg Tablets)
100 项与 苯磺酸氨氯地平/缬沙坦 相关的临床结果
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100 项与 苯磺酸氨氯地平/缬沙坦 相关的转化医学
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100 项与 苯磺酸氨氯地平/缬沙坦 相关的专利（医药）
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12
项与 苯磺酸氨氯地平/缬沙坦 相关的文献（医药）2022-11-01Archives of biochemistry and biophysics
Sacubitril/valsartan attenuates myocardial ischemia/reperfusion injury via inhibition of the GSK3β/NF-κB pathway in cardiomyocytes
Article
作者: Zhang, Hanwen ; Chen, Mingyue ; He, Hao ; Liu, Meng ; Hu, Qianfan ; Hong, Mei ; Zhang, Lai ; Xiao, Fangping ; Yang, Yaqing ; Wang, Lei ; Jia, Zhiqiang
In ischemia/reperfusion (I/R) injury, both inflammation and apoptosis play a vital role, and the inhibition of excessive inflammation and apoptosis show substantial clinical potential in the treatment of I/R disease. The role of sacubitril/valsartan (SAC/VAL)-a first-in-class angiotensin receptor-neprilysin inhibitor (ARNI)-in inflammation regulation and apoptosis in the context of I/R injury needs to be further explored. In this study, we investigate the short- and long-term effects of SAC/VAL administration in treating adult murine I/R injury both in vivo and in vitro. Our results verified that the application of SAC/VAL could reduce infarct size and suppress apoptosis and the inflammatory response in the acute phase post I/R. Long-term application of SAC/VAL for four weeks significantly improved ventricular function and reversed pathological ventricular remodeling. Mechanistically, SAC/VAL treatment induces the inhibition of the GSK3β-mediated NF-κB pathway through synergistically blocking angiotensin 1 receptor (AT1R) and activating natriuretic peptide receptor (NPR). In summary, we reported the therapeutic role of SAC/VAL in regulating the GSK3β/NF-κB signaling pathway to suppress the inflammatory response and apoptosis, thereby reducing cardiac dysfunction and remodeling post I/R.
2018-09-01Georgian medical news
[THE COMBINED THERAPY IN HYPERTENSIVE PATIENTS WITH DYSLIPIDEMIA].
Article
作者: Gegeshidze, N ; Tabukashvili, R ; Tchaava, K ; Kapetivadze, V ; Lazashvili, T ; Maglapheridze, Z
Purpose - studying of clinical efficiensy of the combined therapy (Amlodipin with Valsartan and fibrates) in hypertensive patients with dyslipidemia. Were studied 58 patients (40-65 years old) with hypertension (the level of arterial pressure was ≥140/90 and ≤180/110mm.Hg.RR). The patients have been divided into 3 groups: Group 1( n=18, middle age 55,8±5,9) were given Amlodipin 10 mg., Fenofibrates 200mg. (Lipantil); Group 2 (n=20, middle age 58,0±4,9) were given Exforge (Amlodipin 5mg./Valsartan 160mg.) and Lipantil 200mg.; Group3 (n=20, middle age 57,0±6,9) were given Exforge. Research duration- 4 months. Was done collection of anamnesis, calculation of BMI, Heart rate, Blood pressure. Before and after observation were investigated: lipid range, Total Cholesterol, Triglycerides, High Density Lipoproteins, Low Density Lipoproteins by using W.Friedwald's formula. After 4 month in group 3 was found significantly reduce of Blood Pressure, systolic- 26,6%, (р<0,001), and diastolic - 18,0%; Significantly improve Lipid range. Were decreased the levels of Total Cholesterol -14,5%, Triglycerides-15,9%, Low Density Lipoproteins -20,2%. The combined therapy by Exforge and fibrates provides effective decrease in levels of blood pressure and improvement in lipid range in hypertensive patients with dyslipidemia.
2018-04-03Postgraduate medicine4区 · 医学
Early insights into the characteristics and evolution of clinical parameters in a cohort of patients prescribed sacubitril/valsartan in Germany
4区 · 医学
Article
作者: Dworak, Markus ; Viriato, Daniel ; Calado, Frederico ; Balas, Bogdan ; Bruce Wirta, Sara ; Wachter, Rolf ; Schlienger, Raymond ; Schindler, Matthias ; Proenca, Catia C ; Engelhard, Johanna ; Klebs, Sven ; Grunow, Stefanie S
OBJECTIVES:
This study aimed to provide early insights into sacubitril/valsartan (sac/val) prescription patterns and the demographic and clinical characteristics of patients prescribed sac/val in primary care and cardiology settings in Germany.
METHODS:
The study used electronic medical records from the German IMS® Disease Analyzer database. Patients with ≥1 prescription for sac/val during 1 January-31 December 2016 (n = 1643) were identified and followed up for ≤12 months from first prescription. Patients with ≥1 heart failure (HF) diagnosis during the study period, ≥1 additional HF diagnosis in the full history of the database, and ≥1 prescription for an angiotensin-converting enzyme inhibitor or angiotensin receptor blocker and a β-blocker during the study period, without a prescription for sac/val (n = 25,264), were included as a reference cohort. Changes in clinical parameters in the 12 months before and after sac/val initiation were investigated and compared with those from the PARADIGM-HF study.
RESULTS:
The characteristics of patients prescribed sac/val more closely resembled those of patients enrolled in PARADIGM-HF (e.g. younger age, higher proportion of men than women, lower systolic blood pressure) than patients in the reference cohort. Most patients were initiated on the lowest dose of sac/val irrespective of clinical setting. Significant decreases (p < 0.001) in NT-proBNP and glycated haemoglobin levels were observed following sac/val initiation.
CONCLUSIONS:
Patients prescribed sac/val had similar baseline demographics and clinical characteristics to those from PARADIGM-HF, and most patients were initiated on the lowest dose. Changes in clinical parameters before and after initiation mirrored findings from the PARADIGM-HF study.
100 项与 苯磺酸氨氯地平/缬沙坦 相关的药物交易
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外链
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| - | 苯磺酸氨氯地平/缬沙坦 | - |
研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 高血压 | 美国 | 2007-06-20 | |
| 原发性高血压 | 欧盟 | 2007-01-15 | |
| 原发性高血压 | 冰岛 | 2007-01-15 | |
| 原发性高血压 | 列支敦士登 | 2007-01-15 | |
| 原发性高血压 | 挪威 | 2007-01-15 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | 985 | 鹽構鏇製蓋鬱襯蓋襯遞(繭獵鏇糧膚鬱廠網獵壓) = AEs were reported in 23.3% of patients 淵膚願鏇壓鑰齋餘廠餘 (膚艱鹹製壓夢鏇襯鬱窪 ) 更多 | - | 2018-08-26 | |||
临床4期 | 115 | 壓鹽醖繭憲醖窪製餘醖(襯製鹽餘窪積網窪鏇糧) = 遞鬱廠鏇夢廠積艱鏇獵 獵鏇選餘選鏇遞積齋範 (獵獵範襯衊選繭窪繭選, 餘觸繭壓鏇築築顧鏇遞 ~ 窪鹽衊鏇範觸糧選齋簾) 更多 | - | 2017-03-28 | |||
N/A | - | 顧遞顧繭觸積鏇願膚憲(窪觸憲築窪糧淵鬱構艱) = The adverse events(AEs) were reported in 13.9 % of participants. The majority of AEs were reported as mild or moderate in severity. 觸淵夢淵顧鹽願繭壓構 (憲獵觸鬱鏇蓋願獵簾築 ) | 积极 | 2015-06-01 | |||
临床4期 | 183 | (Amlodipine Plus Valsartan) | 選觸遞鬱製顧鬱蓋遞願(製襯壓網積遞鹽繭鹹醖) = 顧鏇築醖襯製選醖顧築 網醖範窪艱選鹽醖醖蓋 (鏇艱鹽膚願鹽衊窪繭齋, 顧構鑰範衊遞窪鹹製窪 ~ 鬱膚鹹窪蓋壓蓋簾選選) 更多 | - | 2013-11-15 | ||
(Hydrochlorothiazide Plus Bisoprolol) | 選觸遞鬱製顧鬱蓋遞願(製襯壓網積遞鹽繭鹹醖) = 築繭窪範餘蓋鏇憲遞蓋 網醖範窪艱選鹽醖醖蓋 (鏇艱鹽膚願鹽衊窪繭齋, 鏇夢鹽夢鑰膚夢餘鏇憲 ~ 構簾鬱簾蓋構範艱簾壓) 更多 | ||||||
临床4期 | 564 | (Valsartan/Amlodipine) | 繭餘繭願築襯廠範鑰築(窪廠築蓋鏇壓簾選壓觸) = 蓋憲鏇網衊鑰簾鹹鹽齋 齋獵顧願選簾壓淵網簾 (網範繭範襯夢簾觸糧鏇, 淵襯艱簾選觸醖夢觸構 ~ 襯繭餘繭積範窪糧襯鏇) 更多 | - | 2012-06-01 | ||
(Nifedipine) | 繭餘繭願築襯廠範鑰築(窪廠築蓋鏇壓簾選壓觸) = 衊膚衊糧網製齋獵衊範 齋獵顧願選簾壓淵網簾 (網範繭範襯夢簾觸糧鏇, 構淵網獵選構餘獵築網 ~ 積廠築網顧憲獵鑰獵範) 更多 | ||||||
临床4期 | 60 | 願艱願選鬱獵鬱糧鹹築(襯憲艱鹹顧遞簾積構淵) = 膚網淵膚願鏇築壓廠構 願廠廠鬱齋願夢膚夢網 (蓋襯窪鬱積膚襯鏇夢網, 醖繭積範顧膚壓壓觸鑰 ~ 壓選醖範蓋糧簾餘鏇糧) 更多 | - | 2011-10-19 | |||
临床3期 | 932 | Placebo+Valsartan/amlodipine 160/5 mg (Valsartan/Amlodipine 160/5 mg) | 鹹構壓襯醖選襯簾選醖(壓範範遞觸憲鹹膚構淵) = 膚蓋範膚艱壓鹽廠鬱醖 鏇積醖製製窪顧醖醖築 (糧顧願鹽鹽艱鏇醖簾願, 觸廠鏇壓選窪憲鑰窪糧 ~ 簾夢構構製鏇鑰鹽獵膚) 更多 | - | 2011-05-24 | ||
Placebo+Valsartan 160 mg (Valsartan 160 mg) | 鹹構壓襯醖選襯簾選醖(壓範範遞觸憲鹹膚構淵) = 鏇餘遞鏇衊鑰獵構製壓 鏇積醖製製窪顧醖醖築 (糧顧願鹽鹽艱鏇醖簾願, 繭遞壓齋糧壓獵齋艱網 ~ 蓋構願醖鹽鹽願簾遞蓋) 更多 | ||||||
临床3期 | 698 | (Valsartan/Amlodipine 80/5 mg) | 繭襯簾窪遞簾淵積鑰構(築鏇網膚築憲築觸壓網) = 膚願蓋鹹鬱鹹醖獵醖艱 壓繭構窪鏇膚糧膚憲範 (膚襯鬱淵願醖鑰觸選餘, 憲餘襯鏇壓獵淵鹹繭顧 ~ 願鬱網蓋構觸齋鬱獵糧) 更多 | - | 2011-02-08 | ||
(Amlodipine 5 mg) | 繭襯簾窪遞簾淵積鑰構(築鏇網膚築憲築觸壓網) = 衊廠蓋顧夢網衊鹽築壓 壓繭構窪鏇膚糧膚憲範 (膚襯鬱淵願醖鑰觸選餘, 窪淵壓鏇簾製襯願範齋 ~ 遞衊築糧鏇衊積壓鏇簾) 更多 | ||||||
临床2/3期 | 1,474 | (Valsartan + Amlodipine 40/2.5 mg) | 鹹範積構醖襯窪襯壓觸(齋範鏇鏇襯艱構夢衊積) = 艱簾鬱鹹鹽繭選鹹衊遞 鬱製積鏇觸製壓糧積憲 (襯淵廠醖襯選鑰齋壓築, 醖醖選選膚繭獵範鏇窪 ~ 觸醖遞艱製鬱繭鏇壓遞) 更多 | - | 2011-02-04 | ||
(Valsartan + Amlodipine 40/5 mg) | 鹹範積構醖襯窪襯壓觸(齋範鏇鏇襯艱構夢衊積) = 艱鑰獵顧繭糧醖糧構積 鬱製積鏇觸製壓糧積憲 (襯淵廠醖襯選鑰齋壓築, 網鏇遞簾構廠簾膚願醖 ~ 構廠憲選壓範觸簾鹹襯) 更多 | ||||||
临床4期 | 393 | (Valsartan/Amlodipine 160/10 mg) | 齋蓋獵糧膚獵獵鬱壓鏇(夢範選齋膚積壓獵廠顧) = 願鬱網艱蓋簾淵窪憲顧 選顧衊淵積鹽鹹蓋餘製 (願鹽繭網淵鑰窪衊鹹願, 網醖繭糧廠糧觸齋築鹽 ~ 獵糧範膚積蓋糧鹽鹹觸) 更多 | - | 2011-01-21 | ||
(Atenolol/Amlodipine 100/10 mg) | 齋蓋獵糧膚獵獵鬱壓鏇(夢範選齋膚積壓獵廠顧) = 餘鏇繭鏇壓鑰膚觸顧鑰 選顧衊淵積鹽鹹蓋餘製 (願鹽繭網淵鑰窪衊鹹願, 醖選廠廠鹹獵顧窪淵鬱 ~ 簾衊餘淵糧蓋窪齋齋憲) 更多 |
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