预约演示
更新于：2026-06-17
Dexketoprofen Trometamol
右酮洛芬氨丁三醇
更新于：2026-06-17
概要
基本信息
原研机构 |
在研机构 |
非在研机构 |
权益机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C16H14O3 |
InChIKeyDKYWVDODHFEZIM-NSHDSACASA-N |
CAS号22161-81-5 |
关联
90
项与 右酮洛芬氨丁三醇 相关的临床试验CTIS2025-524061-24-01
Study to compare drug availability in the bloodstream of two oral formulations of dexketoprofen in healthy volunteers under fasting conditions.
CTR20250538
一项多中心、随机、双盲、安慰剂平行对照设计，评价右酮洛芬氨丁三醇注射液治疗术后中至重度疼痛的安全性和有效性研究
NCT06878014
Comparison of Safety Profile and Efficacy of Different Doses of Intrathecal Morphine in Total Hip Replacement.
100 项与 右酮洛芬氨丁三醇 相关的临床结果
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100 项与 右酮洛芬氨丁三醇 相关的转化医学
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100 项与 右酮洛芬氨丁三醇 相关的专利（医药）
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1,130
项与 右酮洛芬氨丁三醇 相关的文献（医药）2026-06-01REGIONAL ANESTHESIA AND PAIN MEDICINE
Effect of erector spinae plane block on postoperative nausea and vomiting in lumbar disc herniation surgery
Article
作者: Kavak Akelma, Fatma ; Nalbant, Burak ; Gokbulut Ozaslan, Nihal ; Erdem, Gokhan
Background:
Postoperative nausea and vomiting (PONV) is the most frequent surgical complication after pain. We assessed the effect of the erector spinae plane (ESP) block on PONV incidence, nausea severity, pain levels, rescue antiemetic and analgesic requirements, intraoperative remifentanil use, and the correlation between pain and nausea severity in patients undergoing elective single-level lumbar disc herniation (LDH) surgery.
Methods:
A prospective, randomized, double-blind study included 92 patients with American Society of Anesthesiologists I–II status who were scheduled for lumbar disc herniation surgery under general anesthesia. Patients were randomized into two groups: the ESP group (Group E) and the control group (Group C). The ESP group received bilateral ESP block with 20 mL of 0.25% bupivacaine per side (total 40 mL) alongside standard intraoperative analgesia, while the control group received a sham block. All patients received intravenous ondansetron for PONV prophylaxis. Postoperatively, standard analgesia was provided; patients with a Numerical Rating Scale (NRS) score ≥4 received intravenous dexketoprofen. We defined PONV as significant nausea (NRS≥4), vomiting, or the need for rescue medication. Patients with persistent nausea (>20 min), no improvement in nausea score, or multiple vomiting episodes received 4 mg intravenous ondansetron.
Results:
A total of 81 patients (Group E: 40, Group C: 41) were included in the final analysis. The overall PONV incidence at 0–24 hours was 10% in the ESP group and 34.1% in the control group (p<0.05). The ESP group exhibited a significantly lower incidence of nausea at 0–2, 2–4, and 4–12 hours postoperatively (p<0.05). Rescue antiemetic use was also lower in the ESP group (p<0.05). Intraoperative remifentanil requirements decreased in the ESP group (p<0.05). Pain intensity was significantly lower in the ESP group at 0–2, 2–4, and 4–12 hours (p<0.05), with reduced rescue analgesic use at 0–24 hours (p<0.05). Postoperative pain and nausea intensity showed a strong positive correlation at 0–2 hours (p<0.001), with moderate correlations at 2–4, 4–12 (p<0.001), and 12–24 hours (p=0.003).
Conclusion:
ESP block reduced PONV incidence and severity while providing effective analgesia in LDH surgery. This technique may contribute to multimodal analgesia and PONV prophylaxis.
Trial registration number:
NCT06710457
/
https://www.clinicaltrials.gov/
(November/26/2024).
2026-04-01BIOMEDICAL CHROMATOGRAPHY
A Robust LC‐MS/MS Bioanalytical Strategy for Simultaneous Quantification of Tramadol HCl and Dexketoprofen Trometamol and Its Use in Pharmacokinetic Studies
Article
作者: Sathish Kumar Konidala ; Adusumalli Srinivasa Rao ; P. Bangaraiah
ABSTRACT:
This study reports the first bioanalytical method for simultaneous estimation of Tramadol HCl and dexketoprofen trometamol in rat plasma using Tapentadol as an internal standard. A validated LC‐MS/MS method was developed following USFDA guidelines. Analytes were extracted from plasma by protein precipitation technique using acetonitrile. Chromatographic separation was achieved on a Waters Symmetry Shield RP‐18 column (250 × 4.6 mm, 5 μm) with an isocratic mobile phase of acetonitrile and 0.1% formic acid in HPLC grade water (30:70 v/v) at a flow rate of 1.0 mL/min, yielding a 7‐min runtime. Detection was performed using electrospray ionization with ion transitions of m/z 222.3398 → 70.0307 for Tapentadol, m/z 264.4351 → 96.4527 for Tramadol HCl, and m/z 376.4239 → 100.4520 for dexketoprofen trometamol. The method showed good accuracy, with mean recoveries of 92.79%–98.15% for Tramadol HCl and 91.78%–98.37% for dexketoprofen trometamol. Excellent linearity was obtained, with
r2
values of 0.99983 (22.5–900 ng/mL) and 0.99963 (7.5–300 ng/mL), respectively. All validation parameters met acceptable criteria. The method is suitable for evaluating pharmacokinetic parameters that indicate drug efficacy and safety.
2026-04-01Journal of Orthopaedics
The role of preemptive analgesia with various analgesic drugs in patients undergoing orthopedic surgeries: A systematic review 2015–2020
Review
作者: Mahjub, Hossein ; Moradi, Ahmad ; Bakhshaei, Mohammad Hossein ; Najafi-Vosough, Roya ; Haddadi, Arya ; Pashmakian, Soode
Introduction:
Effective postoperative pain management remains a major challenge, particularly in orthopedic surgeries, as poor control can increase patient stress, prolong opioid use, and delay recovery and hospital discharge. This structured review aimed to evaluate the effectiveness of various analgesic agents in preventing or reducing postoperative pain in patients undergoing orthopedic procedures.
Methods:
A comprehensive systematic search was conducted in the Web of Science, PubMed, and Scopus databases from 2015 up to the end of December 2020. Additionally, the reference lists of relevant articles were screened to identify further eligible studies. Only randomized clinical trials investigating preemptive analgesia in orthopedic surgery patients were included.
Results:
Fourteen articles were initially identified, with five studies meeting the final inclusion criteria. These trials investigated the effects of different pharmacological agents on preemptive pain control. Analgesic effects were observed with intravenous ibuprofen administered prior to incision.For dexketoprofen and tramadol, analgesic benefits were reported in postoperative administration protocols rather than true pre-incision (preemptive) use.
Conclusion:
Preemptive administration of intravenous ibuprofen appears effective in reducing postoperative pain in adults undergoing orthopedic surgery. Evidence for dexketoprofen and tramadol relates primarily to postoperative or perioperative use rather than true preemptive administration.
100 项与 右酮洛芬氨丁三醇 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 术后疼痛 | 中国 | 2023-05-29 | |
| 偏头痛 | 中国 | 2006-10-27 | |
| 疼痛 | 中国 | 2006-10-27 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 绞痛 | 临床3期 | 中国 | 2018-12-27 | |
| 腰痛 | 临床3期 | 中国 | 2018-12-27 | |
| 急性疼痛 | 临床3期 | 西班牙 | 2016-04-12 | |
| 镇痛 | 临床3期 | 中国 | 2015-10-16 | |
| 中度疼痛 | 临床3期 | 中国 | 2015-10-16 | |
| 重度疼痛 | 临床3期 | 中国 | 2015-10-16 | |
| 背痛 | 临床3期 | 中国 | 2015-07-15 | |
| 肾绞痛 | 临床3期 | 中国 | 2015-07-15 |
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临床结果
临床结果
适应症
分期
评价
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临床4期 | 10 | Dexketoprofen chronotherapy | 憲廠築壓鑰繭蓋糧積鏇(顧鑰遞夢鹹鹽遞衊壓淵) = 襯壓襯憲鬱範衊鹽膚簾 鏇築製鬱齋製顧鬱鏇繭 (積鹹範衊構衊築壓觸鹹 ) 更多 | 积极 | 2026-02-01 | ||
Dexketoprofen control therapy | 憲廠築壓鑰繭蓋糧積鏇(顧鑰遞夢鹹鹽遞衊壓淵) = 憲範壓觸膚獵願醖鏇選 鏇築製鬱齋製顧鬱鏇繭 (積鹹範衊構衊築壓觸鹹 ) 更多 | ||||||
临床3期 | - | - | Dexketoprofen 25 mg/Vitamin B (Thiamine 100 mg, Pyridoxine 50 mg, Cyanocobalamin 0.50 mg) FDC | 膚鬱膚齋積醖窪糧顧鏇(獵觸範糧襯襯願網蓋餘) = 繭壓鏇顧選積壓網餘憲 糧鑰鹽顧憲廠憲網齋簾 (廠獵齋膚遞構選願選夢, 2.5 ~ 10.5) | 积极 | 2024-06-01 | |
膚鬱膚齋積醖窪糧顧鏇(獵觸範糧襯襯願網蓋餘) = 壓範築餘醖齋蓋憲範鏇 糧鑰鹽顧憲廠憲網齋簾 (廠獵齋膚遞構選願選夢, 5.0 ~ 13.8) | |||||||
临床3期 | 641 | 糧鬱齋觸壓願遞鏇網淵(簾鑰顧遞願遞觸遞顧艱): P-Value = 0.019 | 积极 | 2016-02-01 | |||
临床4期 | 224 | (Dexketoprofen) | 醖鹽衊獵鹹鹹糧構鏇餘(窪鏇選選鬱鹹鏇蓋蓋齋) = 繭製齋艱醖膚鏇襯壓願 獵鑰願衊鬱鏇繭憲範獵 (範蓋窪願憲鹹艱淵鏇夢, 鏇艱鹽襯鹹淵簾壓構窪 ~ 膚獵願夢築憲積製鏇襯) 更多 | - | 2015-07-23 | ||
(Normal Slaline) | 醖鹽衊獵鹹鹹糧構鏇餘(窪鏇選選鬱鹹鏇蓋蓋齋) = 製願觸獵窪遞襯廠繭廠 獵鑰願衊鬱鏇繭憲範獵 (範蓋窪願憲鹹艱淵鏇夢, 築鹹範糧鏇壓窪鹹淵憲 ~ 淵觸壓顧願繭築糧襯觸) 更多 | ||||||
临床1期 | 26 | (Enantyum® Oral Solution) | 積廠築蓋網廠鑰獵願積(積網齋衊選淵範壓鏇鬱) = 糧鑰窪獵糧廠願廠艱鏇 鑰願鹹鏇構襯範製繭願 (選糧醖網蓋範衊製鹽遞, 餘鏇鬱蓋範壓觸衊選醖 ~ 製鹹遞鹹築鑰製壓積艱) 更多 | - | 2015-07-09 | ||
(Keral® Tablet) | 積廠築蓋網廠鑰獵願積(積網齋衊選淵範壓鏇鬱) = 製觸網顧齋積壓鑰夢夢 鑰願鹹鏇構襯範製繭願 (選糧醖網蓋範衊製鹽遞, 積餘鹹顧繭壓築餘顧淵 ~ 範鹽餘鬱構醖簾遞構淵) 更多 |
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