更新于：2024-11-04
Hydrochlorothiazide/Valsartan
缬沙坦氢氯噻嗪
更新于：2024-11-04
概要
基本信息
药物类型 小分子化药 |
别名 Co-Dio、Co-Diovan、Co-Tareg + [26] |
作用机制 AT1R拮抗剂(血管紧张素II-1型受体拮抗剂)、NCC抑制剂(噻嗪类敏感氯化钠协同转运蛋白抑制剂) |
治疗领域 |
在研适应症 |
非在研适应症 |
最高研发阶段批准上市 |
首次获批日期 美国 (1998-03-06), |
最高研发阶段(中国)无进展 |
特殊审评优先审评 (中国) |
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结构
分子式C31H37ClN8O7S2 |
InChIKeyUIYUUEDFAMZISF-FTBISJDPSA-N |
CAS号186615-83-8 |
关联
52
项与 缬沙坦氢氯噻嗪 相关的临床试验健康受试者在空腹和餐后状态下单次口服缬沙坦氢氯噻嗪片的随机、开放、两序列、两制剂、四周期、完全重复交叉的生物等效性试验
缬沙坦氢氯噻嗪片在中国健康受试者中空腹和餐后单次口服给药、随机、开放、两制剂、三序列、三周期、部分重复交叉生物等效性试验
健康受试者在空腹和餐后状态下单次口服缬沙坦氢氯噻嗪片的随机、开放、两序列、两制剂、四周期、完全重复交叉的生物等效性试验。
100 项与 缬沙坦氢氯噻嗪 相关的临床结果
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100 项与 缬沙坦氢氯噻嗪 相关的转化医学
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100 项与 缬沙坦氢氯噻嗪 相关的专利（医药）
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18
项与 缬沙坦氢氯噻嗪 相关的文献（医药）2023-06-01Nutrition (Burbank, Los Angeles County, Calif.)
Intermittent food restriction upregulates critical hypothalamic genes involved in energy regulation imbalance
Article
作者: Tavares do Carmo, Maria das Graças ; Concha Vilca, Carlos ; Albuquerque, Kelse Tibau de ; Batista, Leandro Oliveira ; Rosas Fernández, Mariana
The effect of intermittent food restriction (IFR) on the Central Nervous System is unclear, especially when alternated with an obesity-inducing diet (DIO). This study aimed to evaluate key genes involved in energy-regulation imbalance in the hypothalamus after IFR and DIO alternation. Therefore, 45-d-old female Wistar rats were divided into 4 groups: standard control (ST-C), fed with an ad libitum standard diet; DIO control (DIO-C), fed with a DIO in the first and last 15 d of the intervention and a standard diet between the 16th and 45th day; standard restricted (ST-R), fed with a standard diet in the first and last 15 d of the intervention followed by IFR at 50% of the ST-C diet between the 16th and 45th day; and DIO restricted (DIO-R), fed with a DIO in the first and last 15 d of the intervention and subjected to IFR under the same conditions as the ST-R group. At 105 d of age, animals were euthanized, and the hypothalamus was removed for quantitative polymerase chain reaction analysis. The ST-R and DIO-R groups showed higher inhibitor of nuclear factor kappa-B kinase subunit beta (P < 0.001; P = 0.029) and nuclear factor kappa B (P < 0.001; P = 0.029) gene expression when compared with the ST-C group. The same held true for the JNK (P = 0.001; P = 0.003) and PPARα genes (both P < 0.001). Instead, the DIO-R group exhibited higher CCL5 gene expression than the ST-C (P = 0.001) and DIO-C (P < 0.001) groups, whereas all groups had higher SOCS3 gene expression than did the ST-C group. These data together suggest that IFR, whether combined with DIO or not, alters the expression of critical genes involved in energy regulation imbalance in the hypothalamus, which warrants caution and more research, because long-term usage might be hazardous.
2023-04-01International journal of social robotics3区 · 计算机科学
Socially Aware Robot Obstacle Avoidance Considering Human Intention and Preferences
3区 · 计算机科学
Article
作者: Smith, Trevor ; Hewitt, Nathan ; Hu, Boyi ; Gu, Yu ; Chen, Yuhao
In order to navigate safely and effectively with humans in close proximity, robots must be capable of predicting the future motions of humans. This study first consolidates human studies in motion, intention, and preference into a discretized human model that can readily be used in robotics decision making algorithms. Cooperative Markov Decision Process (Co-MDP), a novel framework that improves upon Multiagent MDPs, is then proposed for enabling socially aware robot obstacle avoidance. Utilizing the consolidated and discretized human model, Co-MDP allows the system to (1) approximate rational human behavior and intention, (2) generate socially-aware robotic obstacle avoidance behavior, and (3) remain robust to the uncertainty of human intention and motion variance. Simulations of a human-robot co-populated environment verify Co-MDP as a feasible obstacle avoidance algorithm. In addition, the anthropomorphic behavior of Co-MDP was assessed and confirmed with a human-in-the-loop experiment. Results reveal that participants can not directly differentiate agents that were controlled by human operators from Co-MDP, and the reported confidences of their choices indicates that the predictions from participants were backed by behavioral evidence rather than random guesses. Thus the main contributions for this paper are: consolidating past human studies of rational human behavior and intention into a simple, discretized model; the development of Co-MDP: a robotic decision framework that can utilize this human model and maximize the joint utility between the human and robot; and an experimental design for evaluation of the human acceptance of obstacle avoidance algorithms.
2022-04-01Small (Weinheim an der Bergstrasse, Germany)2区 · 材料科学
The Multicomponent Synergistic Effect of Sandwich Structure Hierarchical Nanofibers for Enhanced Sodium Storage
2区 · 材料科学
Article
作者: Zhang, Qiuyu ; Zhang, Fangrong ; Wang, Ting ; Chen, Junjie ; Tian, Nan ; Zhang, Baoliang
Abstract:
Constructing hierarchical micro/nanostructures as anodes for sodium ion batteries is an important approach for exploiting efficient energy storage devices. Herein, sandwich structure hierarchical nanofibers composed of hollow carbon fibers as the substrate, and MoS2 as the interlayer with Co and/or ZnS nanoparticles anchoring in carbon skeletons as the outer shell (carbon nanofiber/MoS2/Co‐ZnS⊂NC) are prepared via a multistep reaction strategy. Profiting from the unique hierarchical structure, abundant migration channels of Na+, and multicomponent synergistic effects, the rapid diffusion kinetics are ensured and the utilization of active materials is maximized. The coaxial structure can evenly disperse volumetric strain, making structural stability guaranteed. Hierarchical nanofibers deliver a high reversible capacity of 352.3 mAh g−1 at 5.0 A g−1 over 3000 cycles. A discharge capacity of 182.5 mAh g−1 is retained even after 10 000 cycles at 10.0 A g−1 as well as a high rate capacity of 202.0 mAh g−1 up to 30 A g−1. The optimal atomic ratio of Co element is further verified by the kinetic analysis. The full‐cells assembled with Na3V2(PO4)3 cathode provide a high capacity of 179.2 mAh g−1 at 1.0 A g−1 for 500 cycles. Combining in situ and ex situ characterizations and theoretical calculations, possible sodium storage mechanisms and the origin of superior electrochemical properties are revealed.
100 项与 缬沙坦氢氯噻嗪 相关的药物交易
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外链
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 高血压 | 美国 | 1998-03-06 |
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10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 原发性高血压 | 临床3期 | 美国 | 2005-10-01 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床4期 | 384 | 築選淵範襯憲壓鑰顧壓(築艱蓋襯糧艱觸築獵艱) = 獵壓餘鏇鹹積築淵鏇餘 簾窪鏇築獵醖衊蓋鹽願 (鏇憲範顧鑰鑰鹹繭簾膚 ) 更多 | - | 2011-10-01 | |||
築選淵範襯憲壓鑰顧壓(築艱蓋襯糧艱觸築獵艱) = 糧製糧襯醖製願醖艱製 簾窪鏇築獵醖衊蓋鹽願 (鏇憲範顧鑰鑰鹹繭簾膚 ) 更多 | |||||||
临床4期 | 384 | (Valsartan) | 鬱簾積範襯鬱觸簾鬱鑰(鹽觸簾鹽衊窪遞簾餘憲) = 築構壓窪網觸顧襯壓構 網選餘齋淵襯製衊壓鹹 (窪廠簾積膚襯襯壓鏇網, 積蓋鹹艱獵顧膚壓築構 ~ 膚選糧鹽顧齋積鹽網窪) 更多 | - | 2010-12-15 | ||
(HCTZ) | 鬱簾積範襯鬱觸簾鬱鑰(鹽觸簾鹽衊窪遞簾餘憲) = 製鏇鑰獵製鏇窪艱醖簾 網選餘齋淵襯製衊壓鹹 (窪廠簾積膚襯襯壓鏇網, 餘鏇淵願餘構鬱網網簾 ~ 遞餘構憲齋鏇壓遞製窪) 更多 | ||||||
临床4期 | 412 | 繭廠餘顧繭鬱簾襯製齋(鬱醖鹹鬱膚醖網糧蓋鏇) = 選夢觸齋鏇餘糧憲衊醖 壓遞醖膚醖窪衊鏇窪鏇 (憲鹽醖網憲夢鏇觸簾觸, 糧膚淵憲築選鬱遞繭膚 ~ 艱蓋築網齋鹽醖鏇醖顧) 更多 | - | 2009-02-10 |
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