更新于：2024-12-06
Empagliflozin/Linagliptin/Metformin Hydrochloride
恩格列净/利格列汀/二甲双胍
更新于：2024-12-06
概要
基本信息
药物类型 小分子化药 |
别名 Empagliflozin/Linagliptin/Metformin、Empagliflozin/metformin/linagliptin、EmpaLinaMet XR + [5] |
作用机制 DPP-4抑制剂(二肽基肽酶IV抑制剂)、PRKAB1激活剂(腺苷酸活化蛋白激酶亚基β1激活剂)、SGLT2抑制剂(钠-葡萄糖协同转运蛋白-2抑制剂) |
治疗领域 |
在研适应症 |
非在研适应症- |
最高研发阶段批准上市 |
首次获批日期 美国 (2020-01-27), |
最高研发阶段(中国)- |
特殊审评- |
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结构
分子式C25H28N8O2 |
InChIKeyLTXREWYXXSTFRX-QGZVFWFLSA-N |
CAS号668270-12-0 |
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关联
3
项与 恩格列净/利格列汀/二甲双胍 相关的临床试验Bioequivalence of a Low Strength Fixed Dose Combination Tablet of Empagliflozin/Linagliptin/Metformin Extended Release Compared to the Free Combination of Empagliflozin, Linagliptin, and Metformin Extended Release Tablets Following Oral Administration in Healthy Male and Female Subjects (an Open-label, Randomised, Single-dose, Two-period, Two-sequence Crossover Study)
Bioequivalence of a Fixed Dose Combination Tablet of Empagliflozin/Linagliptin/Metformin Extended Release Compared to the Free Combination of Empagliflozin, Linagliptin, and Metformin Extended Release Tablets Following Oral Administration in Healthy Male and Female Subjects (an Open-label, Randomised, Single-dose, Two-period, Two-sequence Crossover Study)
Relative Bioavailability of Two FDC Tablet Strengths of Empagliflozin/Linagliptin/Metformin Extended Release Compared to the Free Combination of Empagliflozin, Linagliptin and Metformin Extended Release Following Oral Administration in Healthy Male and Female Subjects (an Open-label, Randomised, Single-dose, Two-period, Two-sequence Crossover Study)
100 项与 恩格列净/利格列汀/二甲双胍 相关的临床结果
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100 项与 恩格列净/利格列汀/二甲双胍 相关的转化医学
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100 项与 恩格列净/利格列汀/二甲双胍 相关的专利（医药）
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2
项与 恩格列净/利格列汀/二甲双胍 相关的文献（医药）2023-03-15BMC chemistry
HPLC-DAD technique for the quantification of a recently approved anti-diabetic triple combination along with two toxic official impurities: Toxicity confirmation aided by molecular docking application.
Article
作者: Kamel, Ebraam B. ; Eissa, Maya S. ; Bahgat, Eman A. ; Hashem, Hisham ; Saleh, Hanaa
BACKGROUND:
Gliflozins and gliptins are two distinct groups of pharmacological drugs that reduce blood glucose levels in individuals with type II diabetes in various ways that may perform their functions harmoniously. Trijardy® tablet, which contains empagliflozin, linagliptin, and metformin, was recently approved. The scientific database does not yet have a method that is sensitive enough to quantify the aforementioned medications in the presence of metformin official toxic impurities melamine and cyanoguanidine. Molecular docking modeling was utilized in this work to further prove the toxicity of melamine.
METHODS:
The five analytes listed before were quantified using RP-HPLC-diode array detector and a Zorbax® C8 column (4.6 × 250 mm, 5 μm) with isocratic mobile phase composed of acetonitrile and 0.05 M potassium dihydrogen phosphate buffer, which had been treated by ?-phosphoric acid to restore a pH of 4.0 (90:10, v/v) at a flow rate of 1.2 mL/min and the eluted peaks were scanned at 250 nm.
CONCLUSION:
The utilization of the simplest isocratic elution mode give the current technique a significant time-and cost-saving benefit. The current method can quantify the triple therapy agents in the presence of each other as well as with two official toxic impurities of metformin in one short analytical run.
2020-06-01The Medical letter on drugs and therapeutics4区 · 医学
In brief: Trijardy XR - a new 3-drug combination for Type 2 diabetes.
4区 · 医学
Article
1
项与 恩格列净/利格列汀/二甲双胍 相关的新闻（医药）2022-08-30
·药时代
100 项与 恩格列净/利格列汀/二甲双胍 相关的药物交易
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外链
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| - | - | - |
研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 2型糖尿病 | 美国 | 2020-01-27 |
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临床结果
临床结果
适应症
分期
评价
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临床1期 | - | 30 | (Empagliflozin/Linagliptin/Metformin FDC (Test)) | 餘廠遞憲膚獵鏇構鹽範(廠鹹餘網艱夢簾廠膚築) = 鏇鑰壓鹹壓襯選願淵觸 鏇鑰夢積繭襯構醖繭壓 (糧選壓艱簾鏇窪艱簾繭, 齋鏇選選範鑰繭糧餘餘 ~ 積鬱憲顧憲蓋築淵壓膚) 更多 | - | 2020-02-21 | |
(Empagliflozin/Linagliptin/Metformin FC (Reference)) | 餘廠遞憲膚獵鏇構鹽範(廠鹹餘網艱夢簾廠膚築) = 壓鏇鹹憲壓淵壓餘窪襯 鏇鑰夢積繭襯構醖繭壓 (糧選壓艱簾鏇窪艱簾繭, 觸製鹹蓋鬱壓獵鑰鹽艱 ~ 鹹鹹製鬱繭艱膚鏇網鬱) 更多 |
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