ACYW群脑膜炎球菌多糖结合疫苗(Meningococcal groups (A/C/Y/W-135) polysaccharide diphtheria toxoid conjugate vaccine(Sanofi)) - 在研适应症：脑膜炎球菌感染，侵袭性脑膜炎球菌病，脑膜炎_专利_临床

概要

基本信息

药物类型

预防性疫苗、类毒素疫苗、结合疫苗

别名

Menactra Infant/Toddler、Menactra Toddler、MenACYW-TT

+ [9]

靶点-

作用方式

刺激剂

作用机制

免疫刺激剂

治疗领域

感染神经系统疾病其他疾病+ [1]

在研适应症

脑膜炎球菌感染侵袭性脑膜炎球菌病脑膜炎+ [2]

非在研适应症-

原研机构

Sanofi

在研机构

Sanofi Pasteur SASanofi Pasteur, Inc.

深圳赛诺菲生物制品有限公司

+ [1]

非在研机构

Sanofi

权益机构

Dr. Reddy's Laboratories Ltd.Sanofi Pasteur, Inc.

Handok, Inc.

+ [1]

最高研发阶段批准上市

首次获批日期

美国 (2005-01-14),

侵袭性脑膜炎球菌病

最高研发阶段(中国)临床3期

特殊审评-

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关联

46

项与 ACYW群脑膜炎球菌多糖结合疫苗相关的临床试验

CTR20253146

/ Active, not recruiting临床3期

一项在中国健康儿童和青少年（2 至 17 岁）中评估研究性四价脑膜炎球菌结合疫苗的免疫原性和安全性的改良双盲、多中心、III 期临床试验

2-6岁人群：评估接种单剂 MenACYW 结合疫苗后与接种单剂A群C群脑膜炎球菌多糖结合疫苗后相比，在A和C血清群脑膜炎的血清学应答和抗体应答方面的非劣效性，对W和Y血清群的血清学应答的充分性，以及安全性的描述。7-17岁人群：评估接种单剂 MenACYW 结合疫苗后与接种单剂ACWY群脑膜炎球菌多糖疫苗后相比，在A，C, W, Y血清群脑膜炎的血清学应答和抗体应答方面的非劣效性以及安全性的描述

开始日期2025-09-27

申办/合作机构

深圳赛诺菲生物制品有限公司

[+1]

NCT06436274

/ Active, not recruiting临床4期IIT

Efficacy of Human Papillomavirus (HPV) Vaccination to Prevent Infection Among Women Living With HIV: A Prospective, Individual, Double-Blind, Randomized Controlled Study.

The Efficacy of Human Papillomavirus (HPV) Vaccination to Prevent Infection Among Women Living with HIV: A Prospective, Individual, Double-Blind, Randomized Controlled Study is evaluating immediate or delayed single-dose nonavalent HPV vaccination among women living with HIV who received prior HPV vaccination.

开始日期2024-10-14

申办/合作机构

The General Hospital Corp.

[+4]

CTR20231927

/ Completed临床1期

一项在中国健康青少年、儿童、幼儿和婴儿中开展的研究性四价脑膜炎球菌结合疫苗的开放标签、年龄递减的安全性和免疫原性 I 期研究

主要目的：（安全性）描述 MenACYW 结合疫苗与对照疫苗（即本地已获批的 A群C群脑膜炎球菌多糖结合疫苗：罗益或绿竹）的安全性特征。次要目的：1. 队列I：给予单剂疫苗后对相应A、C、Y 和 W 血清群脑膜炎球菌以及A 和 C 血清群脑膜炎球菌的抗体应答。2. 队列 II：给予单剂疫苗后对相应A、C、Y 和 W 血清群脑膜炎球菌以及A 和 C 血清群脑膜炎球菌的抗体应答3. 队列 III：给予单剂疫苗后对相应A、C、Y 和 W 血清群脑膜炎球菌以及A 和 C 血清群脑膜炎球菌的抗体应答4. 队列 IV：给予2剂疫苗后对相应A、C、Y 和 W 血清群脑膜炎球菌以及A 和 C 血清群脑膜炎球菌的抗体应答5. 队列 V：给予3剂疫苗后对相应A、C、Y 和 W 血清群脑膜炎球菌以及A 和 C血清群脑膜炎球菌的抗体应答6. 描述在接种前以及接种第 1、2 或 3 剂次相应研究疫苗（MenACYW结合疫苗和对照疫苗）后 30 天，对相应A、C、Y和 W 血清群脑膜炎球菌的免疫原性

开始日期2023-08-12

申办/合作机构

深圳赛诺菲生物制品有限公司

[+1]

100 项与 ACYW群脑膜炎球菌多糖结合疫苗相关的临床结果

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100 项与 ACYW群脑膜炎球菌多糖结合疫苗相关的转化医学

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100 项与 ACYW群脑膜炎球菌多糖结合疫苗相关的专利（医药）

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56

项与 ACYW群脑膜炎球菌多糖结合疫苗相关的文献（医药）

2025-05-01·Infectious Diseases and Therapy

Five-Year Immune Persistence of a Quadrivalent Meningococcal Conjugate Vaccine (MenACYW-TT) and Immunogenicity and Safety of a Booster Dose in Children

Article

作者: Ebert, Rolf ; Syrkina, Olga ; Zocchetti, Céline ; Bertrand-Gerentes, Isabelle ; Martinón-Torres, Federico ; Rämet, Mika ; Bchir, Siham ; Simko, Robert

INTRODUCTION:

Many countries recommend vaccination against Neisseria meningitidis serogroups A, C, W, and Y in infants and young children to prevent invasive meningococcal disease. We evaluated the immunogenicity and safety of a quadrivalent meningococcal tetanus toxoid-conjugate vaccine (MenACYW-TT) booster in children primed with the same meningococcal vaccine 5 years earlier. Immune persistence following priming vaccination was also evaluated, and the study is ongoing to generate 10 years' post-priming data.

METHODS:

Healthy children, vaccinated with MenACYW-TT 5 years earlier as toddlers, were enrolled. Participants were randomized to receive MenACYW-TT booster (group 1) or no booster (group 2), stratified by country and meningococcal serogroup C (MenC) vaccination status (primed at age ≤ 1 year vs. naive). Antibodies against each serogroup were measured by serum bactericidal assay using human complement (hSBA). Seroresponse sufficiency at 30 days post-booster was demonstrated if the lower limit of the one-sided 97.5% confidence interval (CI) of the seroresponse rate (proportion of participants with post-vaccination titers ≥ 1:16 when baseline titers were < 1:8 or with a ≥ fourfold increase when baseline titers were ≥ 1:8) was > 75% for each serogroup. Seroprotection rates (proportion with hSBA titers ≥ 1:8) and geometric mean titers (GMTs) for each serogroup were also assessed.

RESULTS:

A total of 209 participants were enrolled across 26 sites in Finland, Germany, Hungary, and Spain (group 1, n = 93; group 2, n = 116). Five years post-priming, GMTs, and seroprotection rates were higher than those observed before priming vaccination in both groups, indicating long-term persistence. Booster seroresponse rates in group 1 for all serogroups ranged from 93.2% to 98.9%, with seroresponse sufficiency demonstrated (lower limit of one-sided 97.5% CIs for the seroresponse rates ranging from 85.7% to 93.8%). Seroprotection rates and GMTs post-booster increased across all serogroups, with nearly all participants seroprotected, suggesting adequate booster response. Seroresponse was comparable between MenC-primed and MenC-naive participants. No new safety concerns were identified.

CONCLUSIONS:

MenACYW-TT provides long-term immune persistence and a robust immune response when administered as a booster in children primed 5 years earlier.

TRIAL REGISTRATIONS:

Clinicaltrials.gov, NCT04936685; EudraCT: 2021-000104-38; WHO: U1111-1255-4941. Graphical abstract available for this article.

2025-05-01·PEDIATRIC RESEARCH

Quadrivalent meningococcal tetanus toxoid-conjugate booster vaccination in children aged 10–12 years: phase III randomized trial complementary analysis of immune persistence 3–6 years after priming

Letter

作者: Galarza, Katherine ; Zambrano, Betzana ; Zocchetti, Celine ; Bchir, Siham ; Bertrand-Gerentes, Isabelle ; Peterson, James

Impact:

Immune persistence following primary vaccination with a single dose of meningococcal quadrivalent conjugate vaccines, MenACYW-TT/MCV4-CRM, at age 10–12 years was demonstrated.Most participants primed with MenACYW-TT and MCV4-CRM maintained seroprotective titers against all serogroups, suggesting continued protection.Priming with MenACYW-TT resulted in higher persistent titers for serogroups C, W, and Y than MCV4-CRM.A MenACYW-TT booster induced a robust immune response; almost all participants achieved seroprotection against all serogroups.This analysis supports the ACIP recommendations for routine administration of a primary dose of a meningococcal ACWY conjugate vaccine at 11–12 years, with a booster dose at 16 years.

2024-08-01·Infectious Diseases and Therapy

Immunogenicity and Safety of a Quadrivalent Meningococcal Conjugate Vaccine Versus Nimenrix in Healthy Adolescents: A Randomized Phase IIIb Multicenter Study

Article

作者: Icardi, Giancarlo ; Zocchetti, Céline ; Syrkina, Olga ; Simkó, Róbert ; Bertrand-Gerentes, Isabelle ; Chong, Chan Poh ; Bchir, Siham ; Díez-Domingo, Javier

INTRODUCTION:

Many immunization programs in Europe recommend quadrivalent meningococcal vaccinations, which are often administered concomitantly with other vaccines. We compared the immune response of a tetanus toxoid conjugated quadrivalent meningococcal vaccine (MenACYW-TT, MenQuadfi^®) with another quadrivalent meningococcal conjugate vaccine (MCV4-TT; Nimenrix^®) when administered alone or concomitantly with Tdap-IPV and 9vHPV vaccines in adolescents.

METHODS:

In this phase IIIb trial, healthy adolescents (MenC-naïve or MenC-primed before 2 years of age) from Spain, Italy, Hungary, and Singapore were randomized in a 3:3:2 ratio to receive either MenACYW-TT or MCV4-TT alone, or MenACYW-TT concomitantly with 9vHPV and Tdap-IPV. The primary objective was to demonstrate the non-inferiority of the seroprotection rate (human serum bactericidal assay [hSBA] titer ≥ 1:8) to serogroups A, C, W, and Y 30 days post-vaccination with a single dose of MenACYW-TT or MCV4-TT. Secondary objectives included describing hSBA titers for the four serogroups before and 1 month following vaccination and according to MenC priming status.

RESULTS:

A total of 463 participants were enrolled (MenACYW-TT, n = 173; MCV4-TT, n = 173; MenACYW-TT/9vHPV/Tdap-IPV n = 117). Non-inferiority based on seroprotection was demonstrated for MenACYW-TT versus MCV4-TT for all serogroups. Immune responses were comparable whether MenACYW-TT was administered alone or concomitantly with Tdap-IPV and 9vHPV. Post-vaccination hSBA GMTs were higher in MenACYW-TT vs. MCV4-TT for serogroups C, Y, and W and comparable for serogroup A. The percentages of participants with an hSBA vaccine seroresponse were higher in MenACYW-TT vs. MCV4-TT for all serogroups. For serogroup C, higher GMTs were observed in both MenC-naïve or -primed participants vaccinated with MenACYW-TT vs. MCV4-TT. Seroprotection and seroresponse were higher in MenC-naïve participants vaccinated with MenACYW-TT vs. MCV4-TT and comparable in MenC-primed. The safety profiles were comparable between groups and no new safety concerns were identified.

CONCLUSIONS:

These data support the concomitant administration of MenACYW-TT with 9vHPV and Tdap-IPV vaccines in adolescents.

TRIAL REGISTRATIONS:

Clinicaltrials.gov, NCT04490018; EudraCT: 2020-001665-37; WHO: U1111-1249-2973.

22

项与 ACYW群脑膜炎球菌多糖结合疫苗相关的新闻（医药）

2026-06-03

·北京医学感染与传染研究

感染性疾病与治疗 15卷 1-6期

Infectious Diseases and Therapy Volume 15, Issue 1 感染性疾病与治疗 15卷 1期 https://link.springer.com/journal/40121/volumes-and-issues/15-1 Review（综述） 1 How to Better Screen for Blood-Borne Viruses, Specifically HIV, in Hospital Emergency Departments: French and European Perspectives 医院急诊科如何更好地筛查血源性病毒（尤其是HIV）：法国和欧洲视角 Anthony Romain ChauvinBruno George SpireOlivier Bouchaud Pages: 1 - 18 2 Understanding the Epidemiology and Contributing Factors of Post-COVID-19 Pertussis Outbreaks: A Narrative Review 了解新冠疫情后百日咳爆发的流行病学及影响因素：叙述性综述 Juan C. Vargas-ZambranoSorin AbrudanDenis Macina Pages: 19 - 41 Part of 1 collection: Digital Features - Infectious Diseases 所属专题集：数字专题 - 传染病 3 The Structure, Properties, and Clinical Utility of Contezolid for Antituberculosis: A Narrative Review 康替唑胺抗结核的结构、特性及临床应用价值：叙述性综述 Tao ChenWeili LiFan Wu Pages: 43 - 56 4 A Review of Doxycycline Post-Exposure Prophylaxis and Its Implications for Antimicrobial Resistance and the Human Microbiome 综述：多西环素暴露后预防用药及其对抗菌药物耐药性和人体微生物组的影响 Ruben Fernandez-IbanezSantiago MorenoMoises Fernandez Pages: 57 - 84 Original Research（论著） 5 Clinical Impact of Implementing a Specific Clinical Pathway for the Management of Clostridioides difficile Infection 实施特定临床方法治疗艰难梭菌感染的临床影响 Miguel Rodríguez-FernándezRocio HerreroNicolás Merchante Pages: 85 - 100 6 Intensive Care Unit Stay and Mechanical Ventilation Among Adults with Respiratory Syncytial Virus-Related Hospitalization by Age and Comorbidity Status 按年龄和合并症状况划分的呼吸道合胞病毒相关住院成人患者的重症监护病房住院时间和机械通气情况 Caihua LiangYun ZhouElizabeth Begier Pages: 101 - 115 7 Treatment Persistence and Switch Among Medicare-Insured People with HIV and Gaps in Care 医疗保险覆盖的HIV感染者治疗坚持情况、用药转换情况及护理缺口 Suying LiUche MordiPhyllis C. Tien Pages: 117 - 132 8 High-Dose Minocycline Improves Outcomes in Acinetobacter baumannii Group Pneumonia: A Propensity-Weighted Cohort Study with MIC-Based Insights for Breakpoint Revision 大剂量米诺环素可改善鲍曼不动杆菌群肺炎的预后：一项基于倾向加权队列的研究，并基于最低抑菌浓度提出折点修订见解 Yu-Tao TsengYang-Chuan ChenYung-Chih Wang Pages: 133 - 148 9 Post-cranial Neurosurgery Cutibacterium acnes Infections: Clinical Correlates, Presentation, and Outcomes—A Matched Case–Case–Control Study 颅脑神经外科术后皮肤杆菌属感染：临床相关性、表现及预后——一项匹配病例-病例-对照研究 Neta ShirinOfek ArvivIli Margalit Pages: 149 - 164 10 Bone Mineral Density Changes in People with HIV Who had Immediate Switch Versus Deferred Switch from Tenofovir Disoproxil Fumarate-Based Regimens to Bictegravir/Emtricitabine/Tenofovir Alafenamide: A Multicenter, Open-Label, Randomized Clinical Trial 从基于富马酸替诺福韦二吡呋酯的方案立即转换与延迟转换为比克替拉韦/恩曲他滨/丙酚替诺福韦的HIV感染者骨密度变化：一项多中心、开放标签、随机临床试验 Yueming ShaoXinping YangJun Chen Pages: 165 - 181 11 Microbiological, Clinical, and Pharmacokinetic/Pharmacodynamic Data to Support EUCAST Aztreonam–Avibactam Minimum Inhibitory Concentration Susceptibility Breakpoints Against Enterobacterales 支持欧洲抗微生物药物敏感性试验委员会（EUCAST）针对肠杆菌科细菌的氨曲南-阿维巴坦最低抑菌浓度敏感性折点的微生物学、临床及药代动力学/药效学数据 Susan R. RaberRujia XieJoseph W. Chow Pages: 183 - 195 12 Epidemiology of Invasive Escherichia coli Disease in Adults Using Routine Healthcare Records from the United States, 2002–2022 利用美国常规医疗记录（2002-2022年）分析成人侵袭性大肠杆菌病的流行病学特征 Mark A. SchmidtMaxim BlumJeroen Geurtsen Pages: 197 - 216 13 Quality of Life and Treatment Satisfaction in People with HIV Switching to Bictegravir/Emtricitabine/Tenofovir Alafenamide: Pooled Analysis from Observational Cohort Studies 转换为比克替拉韦/恩曲他滨/丙酚替诺福韦的HIV感染者生活质量及治疗满意度：观察性队列研究的汇总分析 Andrea AntinoriYoshiyuki YokomakuMarta Boffito Pages: 217 - 244 14 Dual Transmission Dynamics of Carbapenem Resistance in Pediatric Oncology: Plasmid-Mediated and Clonal Spread of blaNDM-5 Enterobacterales 儿科肿瘤中碳青霉烯类耐药性的双重传播动态：blaNDM-5肠杆菌科的质粒介导与克隆传播 Deena JalalMaryam LotfiLobna Shalaby Pages: 245 - 263 Part of 1 collection:Digital Features - Infectious Diseases 所属专题集：数字专题 - 传染病 15 Cost-Effectiveness Analysis of Aztreonam–Avibactam Compared with Colistin Plus Meropenem in Treating Metallo-Beta-Lactamase-Producing Enterobacterales Infections in Spain 氨曲南-阿维巴坦与黏菌素联合美罗培南治疗西班牙产金属β-内酰胺酶肠杆菌科感染的成本效果分析 Gerardo AguilarPatricia Ruiz-GarbajosaJulián Torre-Cisneros Pages: 265 - 284 16 Synchronous anal HPV Infection in Patients with HPV-Related Gynaecological Diseases: A Prospective Study 人乳头瘤病毒（HPV）相关妇科疾病患者同步肛部HPV感染：一项前瞻性研究 Michał BrzezińskiMaciej Stukan Pages: 285 - 295 17 Growth in Anaerobic Bottles is an Independent Predictor of Mortality in Pseudomonas aeruginosa Bloodstream Infections 厌氧瓶中生长是铜绿假单胞菌血流感染死亡的独立预测因素 Daniel N. MarcoLaura MorataAlex Soriano Pages: 297 - 311 18 Acute and Long-Term Healthcare Utilization and Expenditures for Serious Bacterial Infections among Newborns in US Hospitals 美国医院新生儿严重细菌感染的急性和长期医疗资源利用及费用 Kristen N. NobleKatharina SchleyDerek Weycker Pages: 313 - 325 19 Impact of Risk Stacking on COVID-19–Related Healthcare Utilization: A Real-World Retrospective Cohort Study 风险叠加对新冠相关医疗资源利用的影响：一项现实回顾性队列研究 Frank R. ErnstLeah McGrathAlejandro Cané Pages: 327 - 343 20 Chest Computed Tomography Patterns Associated with Severity in Adults with Respiratory Syncytial Virus Infection: A Retrospective Cohort Study 成人呼吸道合胞病毒感染严重程度相关的胸部计算机断层扫描模式：一项回顾性队列研究 Marie Le GoffYoussef ZaarourNicolas de Prost Pages: 345 - 363 Case Series（病例系列） 21 Management and Resolution of Hypersensitivity Pneumonitis-Related Events in Japanese Patients Treated with Amikacin Liposome Inhalation Suspension in the CONVERT and INS-312 Clinical Trials 在CONVERT和INS-312临床试验中，接受硫酸阿米卡星脂质体吸入混悬液治疗的日本患者发生过敏性肺炎相关事件的管理与解决 Yoshitaka YamazakiTaku NakagawaNaoki Hasegawa Pages: 365 - 379 Letter（读者来信） 22 A Response to: Letter to the Editor Regarding “The Risk of Herpes Zoster in Patients with Depressive Disorders: A German Claims Database Analysis” 对《关于“抑郁障碍患者带状疱疹风险：一项德国索赔数据库分析”的来信》的回复 Pavo MarijicJulian WitteChristiane Hermann Pages: 381 - 383 23 Letter to the Editor Regarding“The Risk of Herpes Zoster in Patients with Depressive Disorders: A German Claims Database Analysis” 致编辑的信：关于“抑郁障碍患者带状疱疹风险：一项德国索赔数据库分析” Kuan-Fu LiaoShih-Wei Lai Pages: 385 - 386 Correction（更正） 24 Correction: Budget Impact Analysis of Fecal Microbiota Spores, Live-brpk (Formerly SER-109) for Recurrent Clostridioides difficile Infection in the United States 更正：美国复发性艰难梭菌感染粪便微生物群孢子活菌brpk（原SER-109）的预算影响分析 Michele WilsonYoav GolanAlpesh N. Amin Pages: 387 - 387 25 Correction: A Response to: Letter to the Editor Regarding “The Risk of Herpes Zoster in Patients with Depressive Disorders: A German Claims Database Analysis” 更正：对《关于“抑郁障碍患者带状疱疹风险：一项德国索赔数据库分析”的来信》的回复 Pavo MarijicJulian WitteChristiane Hermann Pages: 389 – 389 Infectious Diseases and Therapy Volume 15, Issue 2 感染性疾病与治疗 15卷 2期 https://link.springer.com/journal/40121/volumes-and-issues/15-2 Review（综述） 1 HepatitisA to E in People with HIV: A Virus-Specific Review of Prevention and Treatment HIV感染者中的甲型至戊型肝炎：针对不同病毒的预防和治疗综述 Kuan-Yin LinYi-Chia HuangChien-Ching Hung Pages: 391 - 415 2 The Cefazolin Inoculum Effect: An Underappreciated Factor in MSSA Treatment Strategies 头孢唑林接种物效应：甲氧西林敏感金黄色葡萄球菌治疗策略中一个未被充分重视的因素 Prakhar SrivastavaElizabeth SingletonRazieh Kebriaei Pages: 417 - 441 3 Meningococcal Disease in Older Adults: Challenges in Diagnosis and Management 老年人群中的脑膜炎球菌病：诊断与治疗的挑战 Muhamed-Kheir TahaCatherine Weil-OlivierSaber Yezli Pages: 443 - 459 4 The Future of Antibiotics and Artificial Intelligence: Some Thoughts from Discovery to Bedside 抗生素与人工智能的未来：从发现到临床应用的一些思考 Daniele Roberto GiacobbeAlessandra Agnese GrossiCesar de la Fuente-Nunez Pages: 461 - 475 Original Research（论著） 5 Estimating the Health and Economic Burden of Pneumococcal Diseases Attributable to PCV21 Versus PCV20 or PPSV23 Serotypes Among Adults in Norway 挪威成年人中PCV21与PCV20或PPSV23血清型所致肺炎球菌疾病的健康和经济负担估算 Zinan YiAthar Ali TajikKwame Owusu-Edusei Pages: 477 - 490 6 Seven versus Fourteen Days of Antibiotics for Gram-Negative Bacteremia from a Urinary Tract Source: a Systematic Review and Meta-analysis 尿路感染来源的革兰阴性菌血症抗生素治疗7天与14天的系统综述和荟萃分析 Graciela LunaAndrea RodriguezMichael Sabina Pages: 491 - 505 7 Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus Causing Healthcare-Associated Bloodstream Infections in Brazil: Results from A Prospective Countrywide Multicenter Study 巴西医疗保健相关血流感染中耐甲氧西林金黄色葡萄球菌的分子流行病学：一项前瞻性全国多中心研究的结果 Laura C. AntochevisLetícia O. SudbrackAlexandre P. Zavascki Pages: 507 - 525 8 Long-Term Antibody Persistence After Hepatitis A Vaccination in Healthy Toddlers: Insights from Modeling 健康幼儿接种甲型肝炎疫苗后长期抗体持久性：基于模型的见解 Carlos EspulHéctor Horacio CuelloLaurent Coudeville Pages: 527 - 538 9 Prevalence of Respiratory Syncytial Virus in Adult Patients with Respiratory Illnesses in Low to Middle-Income Countries: A Systematic Review and Meta-Analyses 中低收入国家成人呼吸道疾病患者中呼吸道合胞病毒的流行率：一项系统综述和荟萃分析 Digant GuptaAmandeep KaurAdriana Guzman-Holst Pages: 539 - 559 10 Novel Diagnostic Marker Interleukin-33 for Invasive Pulmonary Aspergillosis in Acute-on-Chronic Liver Failure: A Proof-of-Concept Prospective Study 慢加急性肝衰竭合并侵袭性肺曲霉病的新型诊断标志物白细胞介素-33：一项概念验证前瞻性研究 Lanyue HuangMeng ZhangQin Ning Pages: 561 - 576 11 Testing the Feasibility of a Self-Help Intervention That Includes Lymphatic Drainage to Reduce Fatigue-Related Symptoms Among Patients with Long COVID in General Practice: Experiences from Our Randomized Controlled Trial (RCT) 在全科医疗中测试包含淋巴引流以减轻长期新冠患者疲劳相关症状的自助干预措施的可行性：我们的随机对照试验（RCT）经验 Lisa RisteRaymond PerrinAdrian Heald Pages: 577 - 589 12 Comparative Diagnostic Performance of the 36-Minute STANDARD M10 Fast Assay for Molecular Diagnosis of SARS-CoV-2, InfluenzaA and B, and Respiratory Syncytial Virus in Near-Patient Settings 36分钟STANDARD M10快速检测法在床旁检测中对SARS-CoV-2、甲型和乙型流感病毒以及呼吸道合胞病毒的分子诊断性能比较 Alexander DomnichGiada GarzilloGiancarlo Icardi Pages: 591 - 604 13 Clinical Phenotypes of Critically Ill Patients with COVID-19 Infected with Omicron: A Nationwide Prospective Cohort Study 感染奥密克戎的危重症COVID-19患者的临床表型：一项全国性前瞻性队列研究 Etienne AudureauPierre Baythe SEVARVIR investigators Pages: 605 - 628 Brief Report（简报） 14 How do Recent Population-Level RSVpreF Vaccine-Impact Results from the United Kingdom Relate to Previously Reported Vaccine Effectiveness Results? 英国最近公布的RSVpreF疫苗在人群层面的影响结果与之前报告的疫苗有效性结果有何关联？ Negar AliabadiQing LiuElizabeth Begier Pages: 629 - 637 Case Report（病例报告） 15 Continuous Infusion of Aztreonam–Avibactam After High Loading Dose for an Infection Caused by an OXA-48- and NDM-1-Co-producing ST147 Klebsiella pneumoniae 针对OXA-48和NDM-1共产生的ST147型肺炎克雷伯菌感染，采用高负荷剂量后持续输注氨曲南-阿维巴坦 Paul Laffont-LozesFanny VillaRomaric Larcher Pages: 639 - 649 Infectious Diseases and Therapy Volume 15, Issue 3 感染性疾病与治疗 15卷3期 https://link.springer.com/journal/40121/volumes-and-issues/15-3 Commentary（述评） 1 Taxonomy of the Full Health and Societal Value of Maternal Vaccination to Prevent Infant Respiratory Syncytial Virus Disease 预防婴儿呼吸道合胞病毒疾病中孕妇接种疫苗的全面健康及社会价值的分类学研究 J. P. SevillaDaria BurnesDavid E. Bloom Pages: 651 - 682 Original Research（论著） 2 Characteristics of Haemophilus influenzae Isolates Responsible for Invasive Infections in Poland in 2018–2023 2018-2023年波兰引起侵袭性感染的流感嗜血杆菌分离株的特征 Marlena KiedrowskaKinga BłaszczykAnna Skoczyńska Pages: 683 - 700 3 Evaluating the Effectiveness of 2024–2025 Seasonal mRNA-1273 Vaccination Against COVID-19-Related Hospitalizations and Medically Attended COVID-19 Among Adults Aged ≥ 18 years in the United States: An Observational Matched Cohort Study 评估2024-2025年季节性mRNA-1273疫苗对美国≥18岁成年人预防与COVID-19相关住院和就医的效力：一项观察性匹配队列研究 Nevena VicicAlina BogdanovAmanda Wilson Pages: 701 - 714 4 Elevated Plasma GDF-15 Levels Are Associated with Aging, Multimorbidity, and Tobacco Exposure in People with HIV HIV感染者中血浆GDF-15水平升高与衰老、多种合并症及烟草暴露相关 Aida López LópezJacobo Alonso DomínguezCoRIS Cohort Pages: 715 - 731 5 High Burden of Febrile Sub-microscopic Plasmodium Mixed Infections in Central India: A Cross-Sectional Study 印度中部无症状疟原虫混合感染伴发热疾病负担高：一项横断面研究 Nimita DeoraVeena PandeAbhinav Sinha Pages: 733 - 747 6 How Status Quo Bias Shapes Willingness, Uptake, and Adherence to PrEP Among Chinese MSM: A Behavioral Economics Perspective 从行为经济学视角看现状偏见如何影响中国男男性行为者对暴露前预防的意愿、接受度和依从性 Min ZhaoXiang ZhaoLei Zhang Pages: 749 - 767 7 Immunogenicity and Safety of Quadrivalent Meningococcal Conjugate Vaccine (MenACYW-TT) in Potential Hajj/Umrah Pilgrims Aged≥56 Years: A Phase III, Open-Label Study 四价脑膜炎球菌结合疫苗（MenACYW-TT）在≥56岁潜在朝觐/副朝觐者中的免疫原性和安全性：一项III期、开放标签研究 Ghassan S. DbaiboIsmail BalikMehmet Ceyhan Pages: 769 - 785 Part of 1 collection: Digital Features - Infectious Diseases 所属合集：数字专题 -传染病 8 Clinical Impact of Droplet Digital PCR-Guided Antibiotic Stewardship on Prognosis in Patients with Suspected Bloodstream Infection: A Prospective Observational Study 液滴数字PCR指导的抗生素管理对患者疑似血流感染预后的临床影响：一项前瞻性观察研究 Ziqiang ShaoJingwen ZhuBangchuan Hu Pages: 787 - 807 9 Outpatient RSV Testing Rates Among US Adults with Lower Respiratory Tract Disease, 2017–2024 2017-2024年美国下呼吸道疾病成人患者门诊呼吸道合胞病毒检测率 Katherine K. PerezKashmira DateElizabeth Begier Pages: 809 - 834 10 Role of Cefiderocol in the Treatment of Carbapenem-Resistant Nonfermenting Gram-Negative Bacilli (Acinetobacter baumannii, Pseudomonas aeruginosa, and Stenotrophomonas maltophilia) Infections: An Expert Statement 头孢地尔在治疗碳青霉烯类耐药非发酵革兰氏阴性杆菌（鲍曼不动杆菌、铜绿假单胞菌和嗜麦芽窄食单胞菌）感染中的作用：专家声明 Alexandre BleibtreuYoussef BennisCoRIS Cohort Pages: 835 - 857 11 IgG4 Neutralization and Sustained Total IgG Fc-Effector Functions Following Repeated SARS-CoV-2 Vaccination with mRNA-1273 重复接种mRNA-1273疫苗后IgG4中和作用及总IgG Fc效应功能的持续存在 Paulina KaplonekHarry BerteraCarole Henry Pages: 859 - 874 12 Rising Burden of Herpes Zoster among General Adults and Increased-Risk Groups in Eastern China, 2015–2021: A Population-Based Cohort Study 2015-2021年中国东部普通成人及高风险人群带状疱疹负担上升：一项基于人群的队列研究 Zhenwei LiShenjia GuChuanxi Fu Pages: 875 - 888 13 Safety and Efficacy of Fecal Microbiota, Live-jslm for Prevention of Recurrent Clostridioides difficile Infection Among Hospitalized Participants in PUNCH CD3-OLS PUNCH CD3-OLS研究中住院患者使用活菌粪便微生物群（Live-jslm）预防复发性艰难梭菌感染的安全性和有效性 Andrew M. SkinnerThomas P. LodiseJordan E. Axelrad Pages: 889 - 901 Letter（读者来信） 14 Letter to the Editor Regarding “Advanced Liver Disease Events in People with HIV and Hepatitis B Virus Coinfection Initiating Antiretroviral Therapy in the United States” 致编辑的信：关于“美国HIV和乙型肝炎病毒合并感染者启动抗逆转录病毒治疗后发生晚期肝病事件” Keiji Konishi Pages: 903 - 905 15 A Response to: Letter to the Editor Regarding “Advanced Liver Disease Events in People with HIV and Hepatitis B Virus Coinfection Initiating Antiretroviral Therapy in the United States” 回复：致编辑的信——关于“美国HIV和乙型肝炎病毒合并感染者启动抗逆转录病毒治疗后发生晚期肝病事件” Ching-Yi ChuoWoodie ZachryLi Tao Pages: 907 - 909 16 A Response to: “Letter to the Editor regarding ‘Impact of Continuous Renal Replacement Therapy with Polyacrylonitrile-Derived Filter on Caspofungin Concentration: A Retrospective Study'” 回复：致编辑的信——关于“聚丙烯腈衍生滤器连续性肾脏替代治疗对卡泊芬净浓度的影响：一项回顾性研究” Romain ArrestierKeyvan Razazi Pages: 911 - 914 17 Letter to the Editor regarding 'Impact of Continuous Renal Replacement Therapy with Polyacrylonitrile-Derived Filter on Caspofungin Concentration: A Retrospective Study' 致编辑的信——关于“聚丙烯腈衍生滤器连续性肾脏替代治疗对卡泊芬净浓度的影响：一项回顾性研究” Julien MassolValentin MauletFrédéric J. Baud Pages: 915 - 919 Infectious Diseases and Therapy Volume 15, Issue 4 感染性疾病与治疗 15卷 4期 https://link.springer.com/journal/40121/volumes-and-issues/15-4 Review（综述） 1 Outpatient Parenteral Antimicrobial Therapy (OPAT) in Italy: A Scoping Review 意大利门诊静脉注射抗菌药物治疗（OPAT）：一项范围综述 Chiara MorealSimone GiulianoCarlo Tascini Pages: 921 - 939 2 Reimagining Phage Therapy for MDR Pathogens: From Biobanks to Health System Integration—A Review 重新构想噬菌体疗法治疗多重耐药病原体：从生物银行到卫生系统整合——综述 Abay A. AyeleWenfeng LiuAbel A. Negash Pages: 941 - 957 3 Navigating the Viral Hepatitis Drug Landscape: New Discoveries and Enduring Challenges. A Narrative Review 探索病毒性肝炎药物领域：新发现与持久挑战。一篇叙述性综述 He-ming SunXing-yu WangYan-hang Gao Pages: 959 - 985 Original Research（论著） 4 Predictive Utility of the Pediatric-EQUAL Scale in Pediatric Candidemia Admitted to PICU Association with Clinical and Microbiological Factors Related Mortality 儿科-EQUAL量表对入住PICU的念珠菌血症患儿的预测效用：与临床和微生物学因素相关死亡率的关联 Muhterem DuyuAyşe Aşık Pages: 987 - 1001 Publisher Correction（出版商更正） 5 Publisher Correction: Predictive Utility of the Pediatric-EQUAL Scale in Pediatric Candidemia Admitted to PICU Association with Clinical and Microbiological Factors Related Mortality 出版商更正：儿科-EQUAL量表对入住PICU的念珠菌血症患儿的预测效用：与临床和微生物学因素相关死亡率的关联 Muhterem DuyuAyşe Aşık Pages: 1003 - 1005 Original Research（论著） 6 A Statistical Immune Correlates of Protection Model for Predicting Efficacy from Neutralizing Antibody Titers to Establish Immunobridging of Monoclonal Antibodies for Prevention of COVID-19 用于从中和抗体滴度预测疗效以建立预防新冠肺炎单克隆抗体免疫桥接的统计免疫保护相关因素模型 Ilker YalcinLeijun HuMark A. Wingertzahn Pages: 1007 - 1017 7 Early Antibiotic Therapy in Sepsis Without Shock: A Multimethod Study of Heterogeneous Treatment Effects in ICU Patients 无休克性脓毒症的早期抗生素治疗：一项针对ICU患者异质性治疗效果的多方法研究 Peng ZhangTongkun ZuoYing Huang Pages: 1019 - 1033 8 Post-marketing Safety Surveillance of 23-Valent Pneumococcal Polysaccharide Vaccine Administered Alone and Concomitantly with Influenza Vaccine in Individuals Aged 2Years and Older in China 中国2岁及以上人群单独接种及与流感疫苗同时接种23价肺炎球菌多糖疫苗的上市后安全监测 Yun-feng ShiLin-hang JuHong-xing Pan Pages: 1035 - 1046 9 Cost-Effectiveness of Nirsevimab and Clesrovimab in Preventing Respiratory Syncytial Virus Lower Respiratory Tract Disease in Infants in the United States: A Modeling Study 美国预防婴儿呼吸道合胞病毒下呼吸道感染：Nirsevimab和Clesrovimab的成本效益——一项建模研究 Benjamin YarnoffMatthieu BeuveletLeonard R. Krilov Pages: 1047 - 1073 10 Oritavancin in Complicated Bloodstream Infections and Endocarditis in Spain and Italy (ORIBAC Study): A Retrospective Multicenter Observational Study 西班牙和意大利奥利他万星治疗复杂血流感染和心内膜炎（ORIBAC研究）：一项回顾性多中心观察研究 Antonio VenaLaura MezzogoriORIBAC study group Pages: 1075 - 1092 11 Mitigating Vaccine Disparities Through Faith-Based Intervention: A Pre-Post Analysis of Recombinant Zoster Vaccine Knowledge and Acceptance in Socially Vulnerable Racial and Ethnic Minoritized Communities 通过基于信仰的干预措施减轻疫苗差异：对社会弱势的种族和少数民族群体重组带状疱疹疫苗认知和接受度的前后分析 Jacinda C. Abdul-MutakabbirRaheem Abdul-MutakabbirSamuel J. Casey Pages: 1093 - 1114 12 Epidemiological Burden and Hospitalization Trends of Human Metapneumovirus in Spain (2016–2023): A Retrospective Study 西班牙人类偏肺病毒的流行病学负担和住院趋势（2016 - 2023年）：一项回顾性研究 Oscar Brochado-KithRuth Gil-PrietoAngel Gil-de-Miguel Pages: 1115 - 1135 13 Using Real-World Data to Support Claim Expansion of the Cobas SARS-CoV-2 Test in Asymptomatic Testing: Data from the National Football League Occupational Surveillance Program 使用现实数据支持Cobas SARS-CoV-2检测在无症状检测中的适用范围扩大：来自美国国家橄榄球联盟职业监测计划的数据 Baiyu YangErin B. WassermanElodie Baumfeld Andre Pages: 1137 - 1148 Infectious Diseases and Therapy Volume 15, Issue 5 感染性疾病与治疗 15卷 5期 https://link.springer.com/journal/40121/volumes-and-issues/15-5 Review（综述） 1 Efficacy and Safety of Tetracyclines in Bone and Joint Infections: A Literature Review 四环素类药物治疗骨关节感染的有效性和安全性：文献综述 Paul Laffont-LozesRomaric LarcherAlbert Sotto Pages: 1149 - 1174 2 The Ongoing Challenge of Pertussis in Eastern and Northern Europe: Recommendations from the Global Pertussis Initiative 东欧和北欧百日咳持续存在的挑战：全球百日咳倡议的建议 Mine Durusu TanrioverUlrich HeiningerKevin Forsyth Pages: 1175 - 1201 3 Antibiotic Pharmacokinetics and Prostate Penetration in Bacterial Prostatitis: A Systematic Review 细菌性前列腺炎的抗生素药代动力学及前列腺穿透性：系统综述 Rui GeXinwen NianZhuo Wang Pages: 1203 - 1248 4 Treatment for Dientamoeba fragilis: A Systematic Review and Meta-analysis 脆弱双核阿米巴病的治疗：系统综述和荟萃分析 Nadav BaharavMichael ItzkovichDafna Yahav Pages: 1249 - 1262 Original Research（论著） 5 Preparing for Tuberculosis Vaccine M72/AS01E Implementation: A Global Demand Forecast and Key Influential Factors 结核病疫苗M72/AS01E实施准备工作：全球需求预测及关键影响因素 Judith KallenbergDominique MileaAgathe Philippot Pages: 1263 - 1279 Correction（更正） 6 Correction: Preparing for Tuberculosis Vaccine M72/AS01E Implementation: A Global Demand Forecast and Key Influential Factors 更正：结核病疫苗M72/AS01E实施准备工作：全球需求预测及关键影响因素 Judith KallenbergDominique MileaAgathe Philippot Pages: 1281 - 1281 Original Research（论著） 7 Impact of Nirsevimab on Pediatric RSV-Related Lower Respiratory Tract Infections: A Retrospective Pre–Post Observational Study in Tuscany, Italy 尼塞韦单抗对意大利托斯卡纳地区儿童呼吸道合胞病毒相关下呼吸道感染的影响：一项回顾性前后对照观察研究 Francesco NiedduMarta VerzieriMaria Moriondo Pages: 1283 - 1295 8 Antiretroviral Therapy Switching Among People with HIV in the United States is not Uncommon Despite Virologic Suppression: An OPERA Cohort Study 尽管病毒学抑制，美国HIV感染者更换抗逆转录病毒疗法的情况并不少见：OPERA队列研究 Karam MounzerMichael D. OstermanGregory P. Fusco Pages: 1297 - 1314 9 Role of Community Associations in HIV, HBV and HCV Screening and Support for Migrant Populations in France: Results of the DéPAC Study 社区协会在法国移民人群HIV、HBV和HCV筛查及支持中的作用：DéPAC研究结果 Dulce AlfaiateJean-Claude TardyFrançois Durand Pages: 1315 - 1333 Part of 1 collection:Digital Features - Infectious Diseases 所属专题合集：数字专题-传染病 10 Impact of Risk Factor Combinations on Severe COVID-19 Outcomes Among Outpatients 风险因素联合作用对门诊患者严重新冠肺炎预后的影响 Haley J. AppanealVrishali V. LopesAisling R. Caffrey Pages: 1335 - 1351 11 Clinical Outcomes Among Older Adults Hospitalized with Respiratory Syncytial Virus and Influenza Infection: A Retrospective Analysis 老年住院患者呼吸道合胞病毒和流感病毒感染的临床预后：一项回顾性分析 Menucha JurkowiczIli MargalitMichal Mandelboim Pages: 1353 - 1367 12 The Impact and Effectiveness of a Two-Dose Varicella Immunization Program Among School Children: Evidence from Quasi-experimental Analyses 两剂水痘免疫接种计划对学龄儿童的影响和有效性：来自准实验分析的证据 Huiqiao GuXu XieYawen Jiang Pages: 1369 - 1384 13 Lessons Learned: Defining the Right Specifications for Diagnostics in Outbreak Situations 经验教训：疫情情况下确定诊断的正确规范 Markus BeutlerPablo BonvehíAndreas Wieser Pages: 1385 - 1399 14 Post-COVID-19 Burden of Severe Influenza in England Among Overall Population and High-Risk Groups: Results From the INFORM Study, 2022–2023 2022-2023年INFORM研究结果：英格兰地区普通人群和高危人群中新冠肺炎后严重流感的负担 Wilhelmine MeerausLucy CartyLance Turtle Pages: 1401 - 1424 15 Respiratory Syncytial Virus Immunization Strategies for Older Adults in Gulf Cooperation Council Countries: Expert Consensus and Recommendations 海湾合作委员会国家老年人呼吸道合胞病毒免疫接种策略：专家共识和建议 Nawal AlKaabiMohammed AbukhattabSalah Al Awaidy Pages: 1425 - 1449 16 Prospective Study of Treatment with Ensitrelvir for COVID-19 in Patients Undergoing Hemodialysis (PROTECT-HD) 血液透析患者使用恩赛特韦治疗新冠肺炎的前瞻性研究（PROTECT-HD） Mineaki KitamuraTakahiro TakazonoHiroshi Mukae Pages: 1451 - 1466 17 Diagnostic Performance and Clinical Outcomes of Pertussis in Hospitalized Children in Relation to Available Vaccination Status: A Retrospective Cohort Study 在现有疫苗接种情况下，住院患儿百日咳的诊断性能和临床预后：一项回顾性队列研究 Dominika LachowiczBarbara JastrzębskaEdyta Podsiadły Pages: 1467 - 1477 18 Demonstrating Clinical Performance of the Elecsys Anti-SARS-CoV-2 Anti-Nucleocapsid Immunoassay Using Real-World Data to Support Regulatory Decision-Making in the USA 使用现实数据证明Elecsys抗SARS-CoV-2抗核衣壳免疫检测的临床性能，以支持美国监管决策 Eldad A. HodBaiyu YangElodie Baumfeld Andre Pages: 1479 - 1491 19 Efficacy and Safety of Glecaprevir/Pibrentasvir in Participants with Chronic HCV Infection and Comorbidities or Multiple Concomitant Medications: An Integrated Analysis 格卡瑞韦/哌仑他韦治疗慢性丙型肝炎病毒感染且伴有合并症或多种合并用药受试者的有效性和安全性：一项综合分析 Curtis CooperShweta A. RainaStanislas Pol Pages: 1493 - 1508 20 Modeling the Public Health Impact of Introducing 4CMenB Vaccination for Infants in the Brazilian National Immunization Program 在巴西国家免疫计划中引入4CMenB疫苗对公共卫生的影响建模 Thatiana PintoZeki KocaataElise Kuylen Pages: 1509 - 1524 21 Multicenter Real-World Outpatient Use of Intravenous Omadacycline 门诊使用静脉注射奥马环素的多中心现实情况 Lucinda J. Van AnglenCathy L. KooKimberly A. Couch Pages: 1525 - 1538 22 Burden of Respiratory Syncytial Virus in Older ADults in Nagasaki, Japan (Nagasaki ROAD): Preliminary Results (April 2024–March 2025) of a Prospective, Multicenter, Epidemiological Study 日本长崎地区老年人呼吸道合胞病毒负担（长崎ROAD）：一项前瞻性、多中心、流行病学研究的初步结果（2024年4月-2025年3月） Takahiro TakazonoNorihito KakuHiroshi Mukae Pages: 1539 - 1564 Brief Report（简报） 23 Effectiveness of Switching to Bictegravir/Emtricitabine/Tenofovir Alafenamide from Rilpivirine or Other Non-nucleoside Reverse Transcriptase Inhibitor (NNRTI)-Based Antiretroviral Therapy in Virologically Suppressed People with HIV: A Retrospective Analysis (DRIVE-SWITCH Study) 对于病毒学抑制的HIV感染者，从利匹韦林或其他非核苷类逆转录酶抑制剂（NNRTI）为基础的抗逆转录病毒疗法转换为比克替拉韦/恩曲他滨/丙酚替诺福韦的有效性：一项回顾性分析（DRIVE-SWITCH研究） Roberta GagliardiniAlessandro CaioliAndrea Antinori Pages: 1565 - 1575 Infectious Diseases and Therapy Volume 15, Issue 6 感染性疾病与治疗 15卷 6期 https://link.springer.com/journal/40121/volumes-and-issues/15-6 Commentary（述评） 1 Adult RSV Vaccination: What Is the Role of RSV Subgroup in Disease Prevention? 成人RSV疫苗接种：RSV亚群在疾病预防中的作用是什么？ S. Elizabeth WilliamsGiovanni Checcucci LisiElizabeth Begier Pages: 1577 - 1587 Review（综述） 2 Epidemiology of Acute Cystitis or Afebrile Urinary Tract Infection in Adult Men: A Systematic Literature Review 成年男性急性膀胱炎或无热尿路感染的流行病学：一项系统文献综述 Mary E. GeorgiouPriscilla WittkopfFanny S. Mitrani-Gold Pages: 1589 - 1606 3 Non-intravenous Amphotericin B: A Review of Localized Administration Routes 非静脉注射两性霉素B：局部给药途径综述 Francelise Bridi CavassinLaura Fernanda RodriguesMarcello Mihailenko Chaves Magri Pages: 1607 - 1632 4 Infections Caused by Fusobacterium Species: Microbiology, Clinical Syndromes and Management: A Narrative Review Fusobacterium属引起的感染：微生物学、临床综合征及治疗：一篇叙述性综述 Michal ParetGuy KatzenellenbogenDafna Yahav Pages: 1633 - 1647 5 When Culture Results Don’t Tell the Whole Story: A Practical Review of Antibiotics Pitfalls for Clinical Decision-Making 当培养结果不能说明全部问题：临床决策中抗生素陷阱的实用综述 Ahmed M. ShomanAyman A. Radwan Pages: 1649 - 1667 Original Research（论著） 6 Cost-Effectiveness of Alternative Immunization Strategies to Protect Infants Against Respiratory Syncytial Virus in Germany: A Decision Modeling Study 德国保护婴儿免受呼吸道合胞病毒感染的替代免疫策略的成本效益：一项决策模型研究 Caroline LadeErin QuinnAhuva Averin Pages: 1669 - 1687 7 Estimation of Costs Related to the Management of Herpes Zoster and its Complications in Vietnam: A Medical Chart Review 越南带状疱疹及其并发症治疗相关费用估算：一项病历回顾研究 Nurilign AhmedVan M. NguyenHuong T. T. Nguyen Pages: 1689 - 1704 8 Validation of the VIRSTA and VIRSTA+ Scores to Identify Patients with Staphylococcus aureus Bacteremia at Very Low Risk of Infective Endocarditis VIRSTA和VIRSTA+评分验证以识别感染性心内膜炎极低风险的金黄色葡萄球菌菌血症患者 Daniela Malano-BarlettaMiguel Ángel VerdejoAlex Soriano Pages: 1705 - 1718 9 The Shifting Landscape of HIV–Tuberculosis Co-Infection in the MENA Region with a Focus on Saudi Arabia: A Systematic Epidemiological Analysis over Three Decades MENA地区HIV–结核共感染的变化格局：以沙特阿拉伯为重点的三十年系统流行病学分析 Zikria SaleemMasaad Saeed AlmutairiFaris S. Alnezary Pages: 1719 - 1731 10 Comprehensive Analysis of Health Service Utilization for Febrile Illness and Malaria in Malaria-Endemic States in India: LLINs as a Pillar of Control Strategies 印度疟疾流行邦发热疾病和疟疾卫生服务利用的综合分析：长效杀虫蚊帐作为控制策略的支柱 Vani H. ChalageriShrinivasa B. MarinaikAnupkumar R. Anvikar Pages: 1733 - 1746 11 Observational, Post-marketing Surveillance of Safety and Effectiveness of Glecaprevir/Pibrentasvir in Korean Patients with Chronic Hepatitis C 格卡瑞韦/匹布他韦在韩国慢性丙型肝炎患者中的观察性上市后安全性和有效性监测 Jin-Woo LeeSang Hoon AhnJeong Heo Pages: 1747 - 1761 12 Post-Marketing Active Surveillance of Adverse Events Following Quadrivalent Subunit Influenza Vaccine in Healthy Participants Aged≥3 Years in China 中国≥3岁健康人群接种四价亚单位流感疫苗后不良事件的上市后主动监测 Mingwei WeiYu PanHongxing Pan Pages: 1763 - 1778 Systematic Review（系统综述） 13 Point-of-Care Nucleic Acid Amplification Tests for Respiratory Syncytial Virus Detection in Children and Adults: A Systematic Literature Review 用于儿童和成人呼吸道合胞病毒检测的即时核酸扩增检测：一项系统文献综述 Kashmira DateKyle FowlerElizabeth Begier Pages: 1779 - 1799 Correction（勘误） 14 Correction: The Cefazolin Inoculum Effect: An Underappreciated Factor in MSSA Treatment Strategies 勘误：头孢唑林接种效应：MSSA治疗策略中被低估的因素 Prakhar SrivastavaElizabeth SingletonRazieh Kebriaei Pages: 1801 – 1801

2026-05-31

·北京医学感染与传染研究

感染性疾病与治疗 15卷 1-6期（2026年5月31日更新）

Infectious Diseases and Therapy Volume 15, Issue 1 感染性疾病与治疗 15卷 1期 https://link.springer.com/journal/40121/volumes-and-issues/15-1 Review（综述） 1 How to Better Screen for Blood-Borne Viruses, Specifically HIV, in Hospital Emergency Departments: French and European Perspectives 医院急诊科如何更好地筛查血源性病毒（尤其是HIV）：法国和欧洲视角 Anthony Romain ChauvinBruno George SpireOlivier Bouchaud Pages: 1 - 18 2 Understanding the Epidemiology and Contributing Factors of Post-COVID-19 Pertussis Outbreaks: A Narrative Review 了解新冠疫情后百日咳爆发的流行病学及影响因素：叙述性综述 Juan C. Vargas-ZambranoSorin AbrudanDenis Macina Pages: 19 - 41 Part of 1 collection: Digital Features - Infectious Diseases 所属专题集：数字专题 - 传染病 3 The Structure, Properties, and Clinical Utility of Contezolid for Antituberculosis: A Narrative Review 康替唑胺抗结核的结构、特性及临床应用价值：叙述性综述 Tao ChenWeili LiFan Wu Pages: 43 - 56 4 A Review of Doxycycline Post-Exposure Prophylaxis and Its Implications for Antimicrobial Resistance and the Human Microbiome 综述：多西环素暴露后预防用药及其对抗菌药物耐药性和人体微生物组的影响 Ruben Fernandez-IbanezSantiago MorenoMoises Fernandez Pages: 57 - 84 Original Research（论著） 5 Clinical Impact of Implementing a Specific Clinical Pathway for the Management of Clostridioides difficile Infection 实施特定临床方法治疗艰难梭菌感染的临床影响 Miguel Rodríguez-FernándezRocio HerreroNicolás Merchante Pages: 85 - 100 6 Intensive Care Unit Stay and Mechanical Ventilation Among Adults with Respiratory Syncytial Virus-Related Hospitalization by Age and Comorbidity Status 按年龄和合并症状况划分的呼吸道合胞病毒相关住院成人患者的重症监护病房住院时间和机械通气情况 Caihua LiangYun ZhouElizabeth Begier Pages: 101 - 115 7 Treatment Persistence and Switch Among Medicare-Insured People with HIV and Gaps in Care 医疗保险覆盖的HIV感染者治疗坚持情况、用药转换情况及护理缺口 Suying LiUche MordiPhyllis C. Tien Pages: 117 - 132 8 High-Dose Minocycline Improves Outcomes in Acinetobacter baumannii Group Pneumonia: A Propensity-Weighted Cohort Study with MIC-Based Insights for Breakpoint Revision 大剂量米诺环素可改善鲍曼不动杆菌群肺炎的预后：一项基于倾向加权队列的研究，并基于最低抑菌浓度提出折点修订见解 Yu-Tao TsengYang-Chuan ChenYung-Chih Wang Pages: 133 - 148 9 Post-cranial Neurosurgery Cutibacterium acnes Infections: Clinical Correlates, Presentation, and Outcomes—A Matched Case–Case–Control Study 颅脑神经外科术后皮肤杆菌属感染：临床相关性、表现及预后——一项匹配病例-病例-对照研究 Neta ShirinOfek ArvivIli Margalit Pages: 149 - 164 10 Bone Mineral Density Changes in People with HIV Who had Immediate Switch Versus Deferred Switch from Tenofovir Disoproxil Fumarate-Based Regimens to Bictegravir/Emtricitabine/Tenofovir Alafenamide: A Multicenter, Open-Label, Randomized Clinical Trial 从基于富马酸替诺福韦二吡呋酯的方案立即转换与延迟转换为比克替拉韦/恩曲他滨/丙酚替诺福韦的HIV感染者骨密度变化：一项多中心、开放标签、随机临床试验 Yueming ShaoXinping YangJun Chen Pages: 165 - 181 11 Microbiological, Clinical, and Pharmacokinetic/Pharmacodynamic Data to Support EUCAST Aztreonam–Avibactam Minimum Inhibitory Concentration Susceptibility Breakpoints Against Enterobacterales 支持欧洲抗微生物药物敏感性试验委员会（EUCAST）针对肠杆菌科细菌的氨曲南-阿维巴坦最低抑菌浓度敏感性折点的微生物学、临床及药代动力学/药效学数据 Susan R. RaberRujia XieJoseph W. Chow Pages: 183 - 195 12 Epidemiology of Invasive Escherichia coli Disease in Adults Using Routine Healthcare Records from the United States, 2002–2022 利用美国常规医疗记录（2002-2022年）分析成人侵袭性大肠杆菌病的流行病学特征 Mark A. SchmidtMaxim BlumJeroen Geurtsen Pages: 197 - 216 13 Quality of Life and Treatment Satisfaction in People with HIV Switching to Bictegravir/Emtricitabine/Tenofovir Alafenamide: Pooled Analysis from Observational Cohort Studies 转换为比克替拉韦/恩曲他滨/丙酚替诺福韦的HIV感染者生活质量及治疗满意度：观察性队列研究的汇总分析 Andrea AntinoriYoshiyuki YokomakuMarta Boffito Pages: 217 - 244 14 Dual Transmission Dynamics of Carbapenem Resistance in Pediatric Oncology: Plasmid-Mediated and Clonal Spread of blaNDM-5 Enterobacterales 儿科肿瘤中碳青霉烯类耐药性的双重传播动态：blaNDM-5肠杆菌科的质粒介导与克隆传播 Deena JalalMaryam LotfiLobna Shalaby Pages: 245 - 263 Part of 1 collection:Digital Features - Infectious Diseases 所属专题集：数字专题 - 传染病 15 Cost-Effectiveness Analysis of Aztreonam–Avibactam Compared with Colistin Plus Meropenem in Treating Metallo-Beta-Lactamase-Producing Enterobacterales Infections in Spain 氨曲南-阿维巴坦与黏菌素联合美罗培南治疗西班牙产金属β-内酰胺酶肠杆菌科感染的成本效果分析 Gerardo AguilarPatricia Ruiz-GarbajosaJulián Torre-Cisneros Pages: 265 - 284 16 Synchronous anal HPV Infection in Patients with HPV-Related Gynaecological Diseases: A Prospective Study 人乳头瘤病毒（HPV）相关妇科疾病患者同步肛部HPV感染：一项前瞻性研究 Michał BrzezińskiMaciej Stukan Pages: 285 - 295 17 Growth in Anaerobic Bottles is an Independent Predictor of Mortality in Pseudomonas aeruginosa Bloodstream Infections 厌氧瓶中生长是铜绿假单胞菌血流感染死亡的独立预测因素 Daniel N. MarcoLaura MorataAlex Soriano Pages: 297 - 311 18 Acute and Long-Term Healthcare Utilization and Expenditures for Serious Bacterial Infections among Newborns in US Hospitals 美国医院新生儿严重细菌感染的急性和长期医疗资源利用及费用 Kristen N. NobleKatharina SchleyDerek Weycker Pages: 313 - 325 19 Impact of Risk Stacking on COVID-19–Related Healthcare Utilization: A Real-World Retrospective Cohort Study 风险叠加对新冠相关医疗资源利用的影响：一项现实回顾性队列研究 Frank R. ErnstLeah McGrathAlejandro Cané Pages: 327 - 343 20 Chest Computed Tomography Patterns Associated with Severity in Adults with Respiratory Syncytial Virus Infection: A Retrospective Cohort Study 成人呼吸道合胞病毒感染严重程度相关的胸部计算机断层扫描模式：一项回顾性队列研究 Marie Le GoffYoussef ZaarourNicolas de Prost Pages: 345 - 363 Case Series（病例系列） 21 Management and Resolution of Hypersensitivity Pneumonitis-Related Events in Japanese Patients Treated with Amikacin Liposome Inhalation Suspension in the CONVERT and INS-312 Clinical Trials 在CONVERT和INS-312临床试验中，接受硫酸阿米卡星脂质体吸入混悬液治疗的日本患者发生过敏性肺炎相关事件的管理与解决 Yoshitaka YamazakiTaku NakagawaNaoki Hasegawa Pages: 365 - 379 Letter（读者来信） 22 A Response to: Letter to the Editor Regarding “The Risk of Herpes Zoster in Patients with Depressive Disorders: A German Claims Database Analysis” 对《关于“抑郁障碍患者带状疱疹风险：一项德国索赔数据库分析”的来信》的回复 Pavo MarijicJulian WitteChristiane Hermann Pages: 381 - 383 23 Letter to the Editor Regarding“The Risk of Herpes Zoster in Patients with Depressive Disorders: A German Claims Database Analysis” 致编辑的信：关于“抑郁障碍患者带状疱疹风险：一项德国索赔数据库分析” Kuan-Fu LiaoShih-Wei Lai Pages: 385 - 386 Correction（更正） 24 Correction: Budget Impact Analysis of Fecal Microbiota Spores, Live-brpk (Formerly SER-109) for Recurrent Clostridioides difficile Infection in the United States 更正：美国复发性艰难梭菌感染粪便微生物群孢子活菌brpk（原SER-109）的预算影响分析 Michele WilsonYoav GolanAlpesh N. Amin Pages: 387 - 387 25 Correction: A Response to: Letter to the Editor Regarding “The Risk of Herpes Zoster in Patients with Depressive Disorders: A German Claims Database Analysis” 更正：对《关于“抑郁障碍患者带状疱疹风险：一项德国索赔数据库分析”的来信》的回复 Pavo MarijicJulian WitteChristiane Hermann Pages: 389 – 389 Infectious Diseases and Therapy Volume 15, Issue 2 感染性疾病与治疗 15卷 2期 https://link.springer.com/journal/40121/volumes-and-issues/15-2 Review（综述） 1 HepatitisA to E in People with HIV: A Virus-Specific Review of Prevention and Treatment HIV感染者中的甲型至戊型肝炎：针对不同病毒的预防和治疗综述 Kuan-Yin LinYi-Chia HuangChien-Ching Hung Pages: 391 - 415 2 The Cefazolin Inoculum Effect: An Underappreciated Factor in MSSA Treatment Strategies 头孢唑林接种物效应：甲氧西林敏感金黄色葡萄球菌治疗策略中一个未被充分重视的因素 Prakhar SrivastavaElizabeth SingletonRazieh Kebriaei Pages: 417 - 441 3 Meningococcal Disease in Older Adults: Challenges in Diagnosis and Management 老年人群中的脑膜炎球菌病：诊断与治疗的挑战 Muhamed-Kheir TahaCatherine Weil-OlivierSaber Yezli Pages: 443 - 459 4 The Future of Antibiotics and Artificial Intelligence: Some Thoughts from Discovery to Bedside 抗生素与人工智能的未来：从发现到临床应用的一些思考 Daniele Roberto GiacobbeAlessandra Agnese GrossiCesar de la Fuente-Nunez Pages: 461 - 475 Original Research（论著） 5 Estimating the Health and Economic Burden of Pneumococcal Diseases Attributable to PCV21 Versus PCV20 or PPSV23 Serotypes Among Adults in Norway 挪威成年人中PCV21与PCV20或PPSV23血清型所致肺炎球菌疾病的健康和经济负担估算 Zinan YiAthar Ali TajikKwame Owusu-Edusei Pages: 477 - 490 6 Seven versus Fourteen Days of Antibiotics for Gram-Negative Bacteremia from a Urinary Tract Source: a Systematic Review and Meta-analysis 尿路感染来源的革兰阴性菌血症抗生素治疗7天与14天的系统综述和荟萃分析 Graciela LunaAndrea RodriguezMichael Sabina Pages: 491 - 505 7 Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus Causing Healthcare-Associated Bloodstream Infections in Brazil: Results from A Prospective Countrywide Multicenter Study 巴西医疗保健相关血流感染中耐甲氧西林金黄色葡萄球菌的分子流行病学：一项前瞻性全国多中心研究的结果 Laura C. AntochevisLetícia O. SudbrackAlexandre P. Zavascki Pages: 507 - 525 8 Long-Term Antibody Persistence After Hepatitis A Vaccination in Healthy Toddlers: Insights from Modeling 健康幼儿接种甲型肝炎疫苗后长期抗体持久性：基于模型的见解 Carlos EspulHéctor Horacio CuelloLaurent Coudeville Pages: 527 - 538 9 Prevalence of Respiratory Syncytial Virus in Adult Patients with Respiratory Illnesses in Low to Middle-Income Countries: A Systematic Review and Meta-Analyses 中低收入国家成人呼吸道疾病患者中呼吸道合胞病毒的流行率：一项系统综述和荟萃分析 Digant GuptaAmandeep KaurAdriana Guzman-Holst Pages: 539 - 559 10 Novel Diagnostic Marker Interleukin-33 for Invasive Pulmonary Aspergillosis in Acute-on-Chronic Liver Failure: A Proof-of-Concept Prospective Study 慢加急性肝衰竭合并侵袭性肺曲霉病的新型诊断标志物白细胞介素-33：一项概念验证前瞻性研究 Lanyue HuangMeng ZhangQin Ning Pages: 561 - 576 11 Testing the Feasibility of a Self-Help Intervention That Includes Lymphatic Drainage to Reduce Fatigue-Related Symptoms Among Patients with Long COVID in General Practice: Experiences from Our Randomized Controlled Trial (RCT) 在全科医疗中测试包含淋巴引流以减轻长期新冠患者疲劳相关症状的自助干预措施的可行性：我们的随机对照试验（RCT）经验 Lisa RisteRaymond PerrinAdrian Heald Pages: 577 - 589 12 Comparative Diagnostic Performance of the 36-Minute STANDARD M10 Fast Assay for Molecular Diagnosis of SARS-CoV-2, InfluenzaA and B, and Respiratory Syncytial Virus in Near-Patient Settings 36分钟STANDARD M10快速检测法在床旁检测中对SARS-CoV-2、甲型和乙型流感病毒以及呼吸道合胞病毒的分子诊断性能比较 Alexander DomnichGiada GarzilloGiancarlo Icardi Pages: 591 - 604 13 Clinical Phenotypes of Critically Ill Patients with COVID-19 Infected with Omicron: A Nationwide Prospective Cohort Study 感染奥密克戎的危重症COVID-19患者的临床表型：一项全国性前瞻性队列研究 Etienne AudureauPierre Baythe SEVARVIR investigators Pages: 605 - 628 Brief Report（简报） 14 How do Recent Population-Level RSVpreF Vaccine-Impact Results from the United Kingdom Relate to Previously Reported Vaccine Effectiveness Results? 英国最近公布的RSVpreF疫苗在人群层面的影响结果与之前报告的疫苗有效性结果有何关联？ Negar AliabadiQing LiuElizabeth Begier Pages: 629 - 637 Case Report（病例报告） 15 Continuous Infusion of Aztreonam–Avibactam After High Loading Dose for an Infection Caused by an OXA-48- and NDM-1-Co-producing ST147 Klebsiella pneumoniae 针对OXA-48和NDM-1共产生的ST147型肺炎克雷伯菌感染，采用高负荷剂量后持续输注氨曲南-阿维巴坦 Paul Laffont-LozesFanny VillaRomaric Larcher Pages: 639 - 649 Infectious Diseases and Therapy Volume 15, Issue 3 感染性疾病与治疗 15卷3期 https://link.springer.com/journal/40121/volumes-and-issues/15-3 Commentary（述评） 1 Taxonomy of the Full Health and Societal Value of Maternal Vaccination to Prevent Infant Respiratory Syncytial Virus Disease 预防婴儿呼吸道合胞病毒疾病中孕妇接种疫苗的全面健康及社会价值的分类学研究 J. P. SevillaDaria BurnesDavid E. Bloom Pages: 651 - 682 Original Research（论著） 2 Characteristics of Haemophilus influenzae Isolates Responsible for Invasive Infections in Poland in 2018–2023 2018-2023年波兰引起侵袭性感染的流感嗜血杆菌分离株的特征 Marlena KiedrowskaKinga BłaszczykAnna Skoczyńska Pages: 683 - 700 3 Evaluating the Effectiveness of 2024–2025 Seasonal mRNA-1273 Vaccination Against COVID-19-Related Hospitalizations and Medically Attended COVID-19 Among Adults Aged ≥ 18 years in the United States: An Observational Matched Cohort Study 评估2024-2025年季节性mRNA-1273疫苗对美国≥18岁成年人预防与COVID-19相关住院和就医的效力：一项观察性匹配队列研究 Nevena VicicAlina BogdanovAmanda Wilson Pages: 701 - 714 4 Elevated Plasma GDF-15 Levels Are Associated with Aging, Multimorbidity, and Tobacco Exposure in People with HIV HIV感染者中血浆GDF-15水平升高与衰老、多种合并症及烟草暴露相关 Aida López LópezJacobo Alonso DomínguezCoRIS Cohort Pages: 715 - 731 5 High Burden of Febrile Sub-microscopic Plasmodium Mixed Infections in Central India: A Cross-Sectional Study 印度中部无症状疟原虫混合感染伴发热疾病负担高：一项横断面研究 Nimita DeoraVeena PandeAbhinav Sinha Pages: 733 - 747 6 How Status Quo Bias Shapes Willingness, Uptake, and Adherence to PrEP Among Chinese MSM: A Behavioral Economics Perspective 从行为经济学视角看现状偏见如何影响中国男男性行为者对暴露前预防的意愿、接受度和依从性 Min ZhaoXiang ZhaoLei Zhang Pages: 749 - 767 7 Immunogenicity and Safety of Quadrivalent Meningococcal Conjugate Vaccine (MenACYW-TT) in Potential Hajj/Umrah Pilgrims Aged≥56 Years: A Phase III, Open-Label Study 四价脑膜炎球菌结合疫苗（MenACYW-TT）在≥56岁潜在朝觐/副朝觐者中的免疫原性和安全性：一项III期、开放标签研究 Ghassan S. DbaiboIsmail BalikMehmet Ceyhan Pages: 769 - 785 Part of 1 collection: Digital Features - Infectious Diseases 所属合集：数字专题 -传染病 8 Clinical Impact of Droplet Digital PCR-Guided Antibiotic Stewardship on Prognosis in Patients with Suspected Bloodstream Infection: A Prospective Observational Study 液滴数字PCR指导的抗生素管理对患者疑似血流感染预后的临床影响：一项前瞻性观察研究 Ziqiang ShaoJingwen ZhuBangchuan Hu Pages: 787 - 807 9 Outpatient RSV Testing Rates Among US Adults with Lower Respiratory Tract Disease, 2017–2024 2017-2024年美国下呼吸道疾病成人患者门诊呼吸道合胞病毒检测率 Katherine K. PerezKashmira DateElizabeth Begier Pages: 809 - 834 10 Role of Cefiderocol in the Treatment of Carbapenem-Resistant Nonfermenting Gram-Negative Bacilli (Acinetobacter baumannii, Pseudomonas aeruginosa, and Stenotrophomonas maltophilia) Infections: An Expert Statement 头孢地尔在治疗碳青霉烯类耐药非发酵革兰氏阴性杆菌（鲍曼不动杆菌、铜绿假单胞菌和嗜麦芽窄食单胞菌）感染中的作用：专家声明 Alexandre BleibtreuYoussef BennisCoRIS Cohort Pages: 835 - 857 11 IgG4 Neutralization and Sustained Total IgG Fc-Effector Functions Following Repeated SARS-CoV-2 Vaccination with mRNA-1273 重复接种mRNA-1273疫苗后IgG4中和作用及总IgG Fc效应功能的持续存在 Paulina KaplonekHarry BerteraCarole Henry Pages: 859 - 874 12 Rising Burden of Herpes Zoster among General Adults and Increased-Risk Groups in Eastern China, 2015–2021: A Population-Based Cohort Study 2015-2021年中国东部普通成人及高风险人群带状疱疹负担上升：一项基于人群的队列研究 Zhenwei LiShenjia GuChuanxi Fu Pages: 875 - 888 13 Safety and Efficacy of Fecal Microbiota, Live-jslm for Prevention of Recurrent Clostridioides difficile Infection Among Hospitalized Participants in PUNCH CD3-OLS PUNCH CD3-OLS研究中住院患者使用活菌粪便微生物群（Live-jslm）预防复发性艰难梭菌感染的安全性和有效性 Andrew M. SkinnerThomas P. LodiseJordan E. Axelrad Pages: 889 - 901 Letter（读者来信） 14 Letter to the Editor Regarding “Advanced Liver Disease Events in People with HIV and Hepatitis B Virus Coinfection Initiating Antiretroviral Therapy in the United States” 致编辑的信：关于“美国HIV和乙型肝炎病毒合并感染者启动抗逆转录病毒治疗后发生晚期肝病事件” Keiji Konishi Pages: 903 - 905 15 A Response to: Letter to the Editor Regarding “Advanced Liver Disease Events in People with HIV and Hepatitis B Virus Coinfection Initiating Antiretroviral Therapy in the United States” 回复：致编辑的信——关于“美国HIV和乙型肝炎病毒合并感染者启动抗逆转录病毒治疗后发生晚期肝病事件” Ching-Yi ChuoWoodie ZachryLi Tao Pages: 907 - 909 16 A Response to: “Letter to the Editor regarding ‘Impact of Continuous Renal Replacement Therapy with Polyacrylonitrile-Derived Filter on Caspofungin Concentration: A Retrospective Study'” 回复：致编辑的信——关于“聚丙烯腈衍生滤器连续性肾脏替代治疗对卡泊芬净浓度的影响：一项回顾性研究” Romain ArrestierKeyvan Razazi Pages: 911 - 914 17 Letter to the Editor regarding 'Impact of Continuous Renal Replacement Therapy with Polyacrylonitrile-Derived Filter on Caspofungin Concentration: A Retrospective Study' 致编辑的信——关于“聚丙烯腈衍生滤器连续性肾脏替代治疗对卡泊芬净浓度的影响：一项回顾性研究” Julien MassolValentin MauletFrédéric J. Baud Pages: 915 - 919 Infectious Diseases and Therapy Volume 15, Issue 4 感染性疾病与治疗 15卷 4期 https://link.springer.com/journal/40121/volumes-and-issues/15-4 Review（综述） 1 Outpatient Parenteral Antimicrobial Therapy (OPAT) in Italy: A Scoping Review 意大利门诊静脉注射抗菌药物治疗（OPAT）：一项范围综述 Chiara MorealSimone GiulianoCarlo Tascini Pages: 921 - 939 2 Reimagining Phage Therapy for MDR Pathogens: From Biobanks to Health System Integration—A Review 重新构想噬菌体疗法治疗多重耐药病原体：从生物银行到卫生系统整合——综述 Abay A. AyeleWenfeng LiuAbel A. Negash Pages: 941 - 957 3 Navigating the Viral Hepatitis Drug Landscape: New Discoveries and Enduring Challenges. A Narrative Review 探索病毒性肝炎药物领域：新发现与持久挑战。一篇叙述性综述 He-ming SunXing-yu WangYan-hang Gao Pages: 959 - 985 Original Research（论著） 4 Predictive Utility of the Pediatric-EQUAL Scale in Pediatric Candidemia Admitted to PICU Association with Clinical and Microbiological Factors Related Mortality 儿科-EQUAL量表对入住PICU的念珠菌血症患儿的预测效用：与临床和微生物学因素相关死亡率的关联 Muhterem DuyuAyşe Aşık Pages: 987 - 1001 Publisher Correction（出版商更正） 5 Publisher Correction: Predictive Utility of the Pediatric-EQUAL Scale in Pediatric Candidemia Admitted to PICU Association with Clinical and Microbiological Factors Related Mortality 出版商更正：儿科-EQUAL量表对入住PICU的念珠菌血症患儿的预测效用：与临床和微生物学因素相关死亡率的关联 Muhterem DuyuAyşe Aşık Pages: 1003 - 1005 Original Research（论著） 6 A Statistical Immune Correlates of Protection Model for Predicting Efficacy from Neutralizing Antibody Titers to Establish Immunobridging of Monoclonal Antibodies for Prevention of COVID-19 用于从中和抗体滴度预测疗效以建立预防新冠肺炎单克隆抗体免疫桥接的统计免疫保护相关因素模型 Ilker YalcinLeijun HuMark A. Wingertzahn Pages: 1007 - 1017 7 Early Antibiotic Therapy in Sepsis Without Shock: A Multimethod Study of Heterogeneous Treatment Effects in ICU Patients 无休克性脓毒症的早期抗生素治疗：一项针对ICU患者异质性治疗效果的多方法研究 Peng ZhangTongkun ZuoYing Huang Pages: 1019 - 1033 8 Post-marketing Safety Surveillance of 23-Valent Pneumococcal Polysaccharide Vaccine Administered Alone and Concomitantly with Influenza Vaccine in Individuals Aged 2Years and Older in China 中国2岁及以上人群单独接种及与流感疫苗同时接种23价肺炎球菌多糖疫苗的上市后安全监测 Yun-feng ShiLin-hang JuHong-xing Pan Pages: 1035 - 1046 9 Cost-Effectiveness of Nirsevimab and Clesrovimab in Preventing Respiratory Syncytial Virus Lower Respiratory Tract Disease in Infants in the United States: A Modeling Study 美国预防婴儿呼吸道合胞病毒下呼吸道感染：Nirsevimab和Clesrovimab的成本效益——一项建模研究 Benjamin YarnoffMatthieu BeuveletLeonard R. Krilov Pages: 1047 - 1073 10 Oritavancin in Complicated Bloodstream Infections and Endocarditis in Spain and Italy (ORIBAC Study): A Retrospective Multicenter Observational Study 西班牙和意大利奥利他万星治疗复杂血流感染和心内膜炎（ORIBAC研究）：一项回顾性多中心观察研究 Antonio VenaLaura MezzogoriORIBAC study group Pages: 1075 - 1092 11 Mitigating Vaccine Disparities Through Faith-Based Intervention: A Pre-Post Analysis of Recombinant Zoster Vaccine Knowledge and Acceptance in Socially Vulnerable Racial and Ethnic Minoritized Communities 通过基于信仰的干预措施减轻疫苗差异：对社会弱势的种族和少数民族群体重组带状疱疹疫苗认知和接受度的前后分析 Jacinda C. Abdul-MutakabbirRaheem Abdul-MutakabbirSamuel J. Casey Pages: 1093 - 1114 12 Epidemiological Burden and Hospitalization Trends of Human Metapneumovirus in Spain (2016–2023): A Retrospective Study 西班牙人类偏肺病毒的流行病学负担和住院趋势（2016 - 2023年）：一项回顾性研究 Oscar Brochado-KithRuth Gil-PrietoAngel Gil-de-Miguel Pages: 1115 - 1135 13 Using Real-World Data to Support Claim Expansion of the Cobas SARS-CoV-2 Test in Asymptomatic Testing: Data from the National Football League Occupational Surveillance Program 使用现实数据支持Cobas SARS-CoV-2检测在无症状检测中的适用范围扩大：来自美国国家橄榄球联盟职业监测计划的数据 Baiyu YangErin B. WassermanElodie Baumfeld Andre Pages: 1137 - 1148 Infectious Diseases and Therapy Volume 15, Issue 5 感染性疾病与治疗 15卷 5期 https://link.springer.com/journal/40121/volumes-and-issues/15-5 Review（综述） 1 Efficacy and Safety of Tetracyclines in Bone and Joint Infections: A Literature Review 四环素类药物治疗骨关节感染的有效性和安全性：文献综述 Paul Laffont-LozesRomaric LarcherAlbert Sotto Pages: 1149 - 1174 2 The Ongoing Challenge of Pertussis in Eastern and Northern Europe: Recommendations from the Global Pertussis Initiative 东欧和北欧百日咳持续存在的挑战：全球百日咳倡议的建议 Mine Durusu TanrioverUlrich HeiningerKevin Forsyth Pages: 1175 - 1201 3 Antibiotic Pharmacokinetics and Prostate Penetration in Bacterial Prostatitis: A Systematic Review 细菌性前列腺炎的抗生素药代动力学及前列腺穿透性：系统综述 Rui GeXinwen NianZhuo Wang Pages: 1203 - 1248 4 Treatment for Dientamoeba fragilis: A Systematic Review and Meta-analysis 脆弱双核阿米巴病的治疗：系统综述和荟萃分析 Nadav BaharavMichael ItzkovichDafna Yahav Pages: 1249 - 1262 Original Research（论著） 5 Preparing for Tuberculosis Vaccine M72/AS01E Implementation: A Global Demand Forecast and Key Influential Factors 结核病疫苗M72/AS01E实施准备工作：全球需求预测及关键影响因素 Judith KallenbergDominique MileaAgathe Philippot Pages: 1263 - 1279 Correction（更正） 6 Correction: Preparing for Tuberculosis Vaccine M72/AS01E Implementation: A Global Demand Forecast and Key Influential Factors 更正：结核病疫苗M72/AS01E实施准备工作：全球需求预测及关键影响因素 Judith KallenbergDominique MileaAgathe Philippot Pages: 1281 - 1281 Original Research（论著） 7 Impact of Nirsevimab on Pediatric RSV-Related Lower Respiratory Tract Infections: A Retrospective Pre–Post Observational Study in Tuscany, Italy 尼塞韦单抗对意大利托斯卡纳地区儿童呼吸道合胞病毒相关下呼吸道感染的影响：一项回顾性前后对照观察研究 Francesco NiedduMarta VerzieriMaria Moriondo Pages: 1283 - 1295 8 Antiretroviral Therapy Switching Among People with HIV in the United States is not Uncommon Despite Virologic Suppression: An OPERA Cohort Study 尽管病毒学抑制，美国HIV感染者更换抗逆转录病毒疗法的情况并不少见：OPERA队列研究 Karam MounzerMichael D. OstermanGregory P. Fusco Pages: 1297 - 1314 9 Role of Community Associations in HIV, HBV and HCV Screening and Support for Migrant Populations in France: Results of the DéPAC Study 社区协会在法国移民人群HIV、HBV和HCV筛查及支持中的作用：DéPAC研究结果 Dulce AlfaiateJean-Claude TardyFrançois Durand Pages: 1315 - 1333 Part of 1 collection:Digital Features - Infectious Diseases 所属专题合集：数字专题-传染病 10 Impact of Risk Factor Combinations on Severe COVID-19 Outcomes Among Outpatients 风险因素联合作用对门诊患者严重新冠肺炎预后的影响 Haley J. AppanealVrishali V. LopesAisling R. Caffrey Pages: 1335 - 1351 11 Clinical Outcomes Among Older Adults Hospitalized with Respiratory Syncytial Virus and Influenza Infection: A Retrospective Analysis 老年住院患者呼吸道合胞病毒和流感病毒感染的临床预后：一项回顾性分析 Menucha JurkowiczIli MargalitMichal Mandelboim Pages: 1353 - 1367 12 The Impact and Effectiveness of a Two-Dose Varicella Immunization Program Among School Children: Evidence from Quasi-experimental Analyses 两剂水痘免疫接种计划对学龄儿童的影响和有效性：来自准实验分析的证据 Huiqiao GuXu XieYawen Jiang Pages: 1369 - 1384 13 Lessons Learned: Defining the Right Specifications for Diagnostics in Outbreak Situations 经验教训：疫情情况下确定诊断的正确规范 Markus BeutlerPablo BonvehíAndreas Wieser Pages: 1385 - 1399 14 Post-COVID-19 Burden of Severe Influenza in England Among Overall Population and High-Risk Groups: Results From the INFORM Study, 2022–2023 2022-2023年INFORM研究结果：英格兰地区普通人群和高危人群中新冠肺炎后严重流感的负担 Wilhelmine MeerausLucy CartyLance Turtle Pages: 1401 - 1424 15 Respiratory Syncytial Virus Immunization Strategies for Older Adults in Gulf Cooperation Council Countries: Expert Consensus and Recommendations 海湾合作委员会国家老年人呼吸道合胞病毒免疫接种策略：专家共识和建议 Nawal AlKaabiMohammed AbukhattabSalah Al Awaidy Pages: 1425 - 1449 16 Prospective Study of Treatment with Ensitrelvir for COVID-19 in Patients Undergoing Hemodialysis (PROTECT-HD) 血液透析患者使用恩赛特韦治疗新冠肺炎的前瞻性研究（PROTECT-HD） Mineaki KitamuraTakahiro TakazonoHiroshi Mukae Pages: 1451 - 1466 17 Diagnostic Performance and Clinical Outcomes of Pertussis in Hospitalized Children in Relation to Available Vaccination Status: A Retrospective Cohort Study 在现有疫苗接种情况下，住院患儿百日咳的诊断性能和临床预后：一项回顾性队列研究 Dominika LachowiczBarbara JastrzębskaEdyta Podsiadły Pages: 1467 - 1477 18 Demonstrating Clinical Performance of the Elecsys Anti-SARS-CoV-2 Anti-Nucleocapsid Immunoassay Using Real-World Data to Support Regulatory Decision-Making in the USA 使用现实数据证明Elecsys抗SARS-CoV-2抗核衣壳免疫检测的临床性能，以支持美国监管决策 Eldad A. HodBaiyu YangElodie Baumfeld Andre Pages: 1479 - 1491 19 Efficacy and Safety of Glecaprevir/Pibrentasvir in Participants with Chronic HCV Infection and Comorbidities or Multiple Concomitant Medications: An Integrated Analysis 格卡瑞韦/哌仑他韦治疗慢性丙型肝炎病毒感染且伴有合并症或多种合并用药受试者的有效性和安全性：一项综合分析 Curtis CooperShweta A. RainaStanislas Pol Pages: 1493 - 1508 20 Modeling the Public Health Impact of Introducing 4CMenB Vaccination for Infants in the Brazilian National Immunization Program 在巴西国家免疫计划中引入4CMenB疫苗对公共卫生的影响建模 Thatiana PintoZeki KocaataElise Kuylen Pages: 1509 - 1524 21 Multicenter Real-World Outpatient Use of Intravenous Omadacycline 门诊使用静脉注射奥马环素的多中心现实情况 Lucinda J. Van AnglenCathy L. KooKimberly A. Couch Pages: 1525 - 1538 22 Burden of Respiratory Syncytial Virus in Older ADults in Nagasaki, Japan (Nagasaki ROAD): Preliminary Results (April 2024–March 2025) of a Prospective, Multicenter, Epidemiological Study 日本长崎地区老年人呼吸道合胞病毒负担（长崎ROAD）：一项前瞻性、多中心、流行病学研究的初步结果（2024年4月-2025年3月） Takahiro TakazonoNorihito KakuHiroshi Mukae Pages: 1539 - 1564 Brief Report（简报） 23 Effectiveness of Switching to Bictegravir/Emtricitabine/Tenofovir Alafenamide from Rilpivirine or Other Non-nucleoside Reverse Transcriptase Inhibitor (NNRTI)-Based Antiretroviral Therapy in Virologically Suppressed People with HIV: A Retrospective Analysis (DRIVE-SWITCH Study) 对于病毒学抑制的HIV感染者，从利匹韦林或其他非核苷类逆转录酶抑制剂（NNRTI）为基础的抗逆转录病毒疗法转换为比克替拉韦/恩曲他滨/丙酚替诺福韦的有效性：一项回顾性分析（DRIVE-SWITCH研究） Roberta GagliardiniAlessandro CaioliAndrea Antinori Pages: 1565 - 1575 Infectious Diseases and Therapy Volume 15, Issue 6 感染性疾病与治疗 15卷 6期 https://link.springer.com/journal/40121/volumes-and-issues/15-6 Commentary（述评） 1 Adult RSV Vaccination: What Is the Role of RSV Subgroup in Disease Prevention? 成人RSV疫苗接种：RSV亚群在疾病预防中的作用是什么？ S. Elizabeth WilliamsGiovanni Checcucci LisiElizabeth Begier Pages: 1577 - 1587 Review（综述） 2 Epidemiology of Acute Cystitis or Afebrile Urinary Tract Infection in Adult Men: A Systematic Literature Review 成年男性急性膀胱炎或无热尿路感染的流行病学：一项系统文献综述 Mary E. GeorgiouPriscilla WittkopfFanny S. Mitrani-Gold Pages: 1589 - 1606 3 Non-intravenous Amphotericin B: A Review of Localized Administration Routes 非静脉注射两性霉素B：局部给药途径综述 Francelise Bridi CavassinLaura Fernanda RodriguesMarcello Mihailenko Chaves Magri Pages: 1607 - 1632 4 Infections Caused by Fusobacterium Species: Microbiology, Clinical Syndromes and Management: A Narrative Review Fusobacterium属引起的感染：微生物学、临床综合征及治疗：一篇叙述性综述 Michal ParetGuy KatzenellenbogenDafna Yahav Pages: 1633 - 1647 5 When Culture Results Don’t Tell the Whole Story: A Practical Review of Antibiotics Pitfalls for Clinical Decision-Making 当培养结果不能说明全部问题：临床决策中抗生素陷阱的实用综述 Ahmed M. ShomanAyman A. Radwan Pages: 1649 - 1667 Original Research（论著） 6 Cost-Effectiveness of Alternative Immunization Strategies to Protect Infants Against Respiratory Syncytial Virus in Germany: A Decision Modeling Study 德国保护婴儿免受呼吸道合胞病毒感染的替代免疫策略的成本效益：一项决策模型研究 Caroline LadeErin QuinnAhuva Averin Pages: 1669 - 1687 7 Estimation of Costs Related to the Management of Herpes Zoster and its Complications in Vietnam: A Medical Chart Review 越南带状疱疹及其并发症治疗相关费用估算：一项病历回顾研究 Nurilign AhmedVan M. NguyenHuong T. T. Nguyen Pages: 1689 - 1704 8 Validation of the VIRSTA and VIRSTA+ Scores to Identify Patients with Staphylococcus aureus Bacteremia at Very Low Risk of Infective Endocarditis VIRSTA和VIRSTA+评分验证以识别感染性心内膜炎极低风险的金黄色葡萄球菌菌血症患者 Daniela Malano-BarlettaMiguel Ángel VerdejoAlex Soriano Pages: 1705 - 1718 9 The Shifting Landscape of HIV–Tuberculosis Co-Infection in the MENA Region with a Focus on Saudi Arabia: A Systematic Epidemiological Analysis over Three Decades MENA地区HIV–结核共感染的变化格局：以沙特阿拉伯为重点的三十年系统流行病学分析 Zikria SaleemMasaad Saeed AlmutairiFaris S. Alnezary Pages: 1719 - 1731 10 Comprehensive Analysis of Health Service Utilization for Febrile Illness and Malaria in Malaria-Endemic States in India: LLINs as a Pillar of Control Strategies 印度疟疾流行邦发热疾病和疟疾卫生服务利用的综合分析：长效杀虫蚊帐作为控制策略的支柱 Vani H. ChalageriShrinivasa B. MarinaikAnupkumar R. Anvikar Pages: 1733 - 1746 11 Observational, Post-marketing Surveillance of Safety and Effectiveness of Glecaprevir/Pibrentasvir in Korean Patients with Chronic Hepatitis C 格卡瑞韦/匹布他韦在韩国慢性丙型肝炎患者中的观察性上市后安全性和有效性监测 Jin-Woo LeeSang Hoon AhnJeong Heo Pages: 1747 - 1761 12 Post-Marketing Active Surveillance of Adverse Events Following Quadrivalent Subunit Influenza Vaccine in Healthy Participants Aged≥3 Years in China 中国≥3岁健康人群接种四价亚单位流感疫苗后不良事件的上市后主动监测 Mingwei WeiYu PanHongxing Pan Pages: 1763 - 1778 Systematic Review（系统综述） 13 Point-of-Care Nucleic Acid Amplification Tests for Respiratory Syncytial Virus Detection in Children and Adults: A Systematic Literature Review 用于儿童和成人呼吸道合胞病毒检测的即时核酸扩增检测：一项系统文献综述 Kashmira DateKyle FowlerElizabeth Begier Pages: 1779 - 1799 Correction（勘误） 14 Correction: The Cefazolin Inoculum Effect: An Underappreciated Factor in MSSA Treatment Strategies 勘误：头孢唑林接种效应：MSSA治疗策略中被低估的因素 Prakhar SrivastavaElizabeth SingletonRazieh Kebriaei Pages: 1801 – 1801

微生物疗法临床结果临床1期

2026-05-17

·生物咖啡茶

5月18日要闻|全球首例iPS药物日本获批！礼来12亿收购Ventyx！再生元LAG-3临床结果揭晓！华赛伯曼TIL疗法冲刺II期！京东健康细胞医院开业

国内信息 1. 华赛伯曼FAST-TIL疗法关键II期临床全国启动 2026年5月16日，由华赛伯曼自主研发的创新肿瘤浸润淋巴细胞（TIL）疗法——FAST-TIL（HS-IT101）治疗晚期黑色素瘤关键II期临床研究全国启动会在南宁召开。该研究由北京大学肿瘤医院郭军教授担任全国牵头研究者，联合全国17家顶级临床研究中心共同推进。此次启动标志着该疗法在重塑中国黑色素瘤免疫治疗格局方面迈出了关键一步，旨在为难治性晚期黑色素瘤患者提供新的治疗希望。 2. 京东健康旗下细胞治疗医院正式开业 2026年5月15日，京东健康朗健维细胞治疗医院在河北秦皇岛北戴河新区正式开业。作为北戴河生命健康产业创新示范区的重要项目之一，该医院的落地标志着京东健康正式深入布局细胞治疗与精准医疗领域，同时也为当地生命健康产业增添了重要的基础设施平台，有助于推动相关技术的临床转化与应用。 3. 爱萨尔生物间充质干细胞新药临床申请获CDE受理 2026年5月15日，国家药品监督管理局药品审评中心（CDE）官网公示，正式受理了上海爱萨尔生物医药股份有限公司申报的IxCell hUC-MSC-P注射液的临床试验申请。该产品是一款治疗用生物制品1类新药，旨在利用间充质干细胞技术，为难治性疾病特发性肺纤维化提供新的治疗方案，有望破解当前的治疗难题。 4. 达歌生物完成4000万美元A轮扩展融资 2026年5月14日，专注于开发分子胶降解剂药物的临床阶段生物技术公司达歌生物（Degron Therapeutics）宣布，已成功完成4000万美元的A轮扩展融资。本轮融资由龙磐资本领投，所筹资金将主要用于推进其核心管线的临床开发进程，标志着资本市场对分子胶这一前沿技术领域的持续看好。 5. 柯君医药完成超3亿元C轮融资，沃森生物领投 2026年第一季度，专注于mRNA技术的创新药企柯君医药宣布完成超过3亿元人民币的C轮融资，本轮由沃森生物领投。柯君医药已构建起“奥胜”mRNA技术平台和“璞玉”前药技术平台，融资将加速其多条核心管线的全球临床开发，在心血管、代谢及抗病毒等领域布局创新药物。 6. 中慧生物中美双报RSV疫苗启动I/II期临床 2026年5月16日，江苏中慧生物宣布其自主研发的重组呼吸道合胞病毒（RSV）疫苗（CHO细胞）（佐剂）I/II期临床试验已正式启动。这是该公司首个中美双报双批的疫苗品种，继2025年8月获得中国国家药监局临床试验批准后，在临床开发阶段取得的关键进展，标志着国产创新疫苗研发再提速。 7. 瑞宙生物MCV4疫苗临床试验申请获受理 2026年5月14日，瑞宙生物联合上海微宙、长春瑞宙共同申报的ACYW135群脑膜炎球菌结合疫苗（MCV4）临床试验申请正式获得CDE受理。这也标志着国产流脑疫苗升级赛道彻底告别“一家独大”，正式进入多家企业同台竞速的新阶段，将进一步丰富国内针对流行性脑脊髓膜炎的预防手段。 8. Evinova中国与金赛药业达成战略合作 2026年5月16日，全球领先的医疗科技公司Evinova中国与致力于开发全球领先创新药物的金赛药业宣布达成战略合作。双方将在2026 DIA药物信息大会上正式签约，旨在通过人工智能（AI）赋能的临床研究开发平台，推动生命科学领域在数字医疗方面的进步，携手推进AI驱动的生物制药创新。 9. 博腾股份提示重大风险，面临约5470万欧元索赔 2026年5月13日，重庆博腾制药科技股份有限公司（博腾股份）发布公告，称其全资子公司Porton PharmaTech在斯洛文尼亚建设的研发生产基地项目存在重大争议。该争议可能导致公司面临约5470万欧元的索赔，这将对博腾股份2026年度的财务状况及经营业绩构成重大不利影响，显示出中国CXO企业在海外扩张中面临的合规与法律风险。国际信息 1. 礼来12亿美元收购Ventyx，加码炎症靶点布局 2026年5月17日，美国制药巨头礼来公司宣布以约12亿美元的全现金方式，完成对美国生物科技公司Ventyx Biosciences的收购。此举旨在强化其在NLRP3系统炎症靶点领域的布局，特别是获得了Ventyx核心资产VTX3232这款具备中枢渗透能力的NLRP3抑制剂。此次收购也意味着礼来在与赛诺菲等公司的潜在竞争中胜出，将该资产及其研发团队尽收囊中。 2. 全球首款iPS细胞药物在日本定价出炉并纳入医保 2026年5月16日，日本正式批准将一款用于治疗帕金森病的诱导多能干细胞（iPSC）再生医疗产品纳入国家医保。该药物由住友制药研发，名为Amchepry，单人全额定价高达5530.6737万日元（折合约238万元人民币）。预计最快今年秋季即可开展临床使用，这将是全球范围内iPS细胞再生医疗产品商业化的重要里程碑。 3. 再生元公布LAG-3抑制剂联合疗法III期临床结果 2026年5月15日，再生元制药公司（Regeneron）公布了评估其LAG-3抑制剂菲安利单抗联合PD-1抑制剂西米普利单抗一线治疗不可切除或转移性黑色素瘤的III期临床试验结果。虽然该试验未达到无进展生存期（PFS）改善的主要终点，但在大剂量菲安利单抗联合疗法组中，观察到中位PFS有5.1个月的数字改善，为后续研发提供了重要数据参考。 ——▼—— ——▼—— 关于好思康北京好思康科技有限公司致力于生物制药行业技术交流、咨询服务和线上一体化平台，旨在促进生物制药技术发展。公司主要业务有： 1.技术交流和推广生物咖啡茶微信公众号和网站，是好思康打造的生物制药行业免费技术交流平台，其中包括每个工作日的早茶有料生物要闻、生物工艺技术和产品资料汇编等栏目，同时为生物工艺企业提供免费广告推送服务。生物咖啡茶根据用户需要组织举办生物工艺技术交流沙龙、论坛；不定期举办企业家读书沙龙等。 2.线上平台服务好思康面向生物制药行业和生物工艺行业提供全新一体化平台服务，涉及抗体企业、疫苗企业、生物工艺上下游企业等；不同企业的主打产品均可在平台进行登记展示推广。联系我们加入生物咖啡群、广告推广合作联系人：段先生联系微信：18501151021 请注明：姓名+所在单位名称+职务 END ▼ 交流生物工艺，关注生物咖啡茶 ▼

100 项与 ACYW群脑膜炎球菌多糖结合疫苗相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	-	J07AH08	-

研发状态

批准上市

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
脑膜炎球菌感染	加拿大	Sanofi Pasteur SA	2006-10-20
侵袭性脑膜炎球菌病	美国	Sanofi Pasteur, Inc.	2005-01-14

未上市

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
脑膜炎	临床3期	沙特阿拉伯	Sanofi Pasteur SA	2007-02-01
流行性脑脊髓膜炎	临床3期	美国	Sanofi Pasteur SA	2006-09-01
MAPK突变实体瘤	临床申请批准	中国	Sanofi Pasteur SA	2026-03-06
MAPK突变实体瘤	临床申请批准	中国	深圳赛诺菲生物制品有限公司	2026-03-06

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT03964012 (NmCV-5, Pubmed \| N Engl J Med)	临床3期	脑膜炎球菌感染	1,800	Conjugate Vaccine (NmCV-5)	淵積鹽繭範製鹽鹹觸餘(淵積廠齋廠艱範願淵鑰) = The incidence of systemic adverse events was similar in the two groups (11.1% in the NmCV-5 group and 9.2% in the MenACWY-D group) 醖製蓋構顧膚淵蓋衊艱 (窪淵糧廠夢餘艱選鹹網 )	积极	2023-05-25
NCT04368429 (CTgov)	临床3期	接种疫苗	360	Meningococcal Polysaccharide (Serogroups A, C, Y, and W)+Meningococcal Polysaccharide (Serogroups A, C, Y, (Group 1: MenACYW Conjugate Vaccine)	醖膚廠壓積鏇獵窪積鏇 = 鹹積淵鏇艱選簾觸鬱醖廠觸齋壓襯窪製廠鹹襯 (餘淵廠簾遞顧獵廠襯鑰, 觸築蓋鹽廠齋醖選糧鹽 ~ 醖夢鹽網醖糧網壓網壓) 更多	-	2021-10-06
				Meningococcal (Groups A, C, Y and W 135) Polysaccharide Diphtheria (Group 2: Menactra® Vaccine)	醖膚廠壓積鏇獵窪積鏇 = 餘積鹽鬱積壓鹹築鹽淵廠觸齋壓襯窪製廠鹹襯 (餘淵廠簾遞顧獵廠襯鑰, 網選選淵廠顧廠壓餘獵 ~ 範蓋積憲網衊鏇築醖鬱) 更多
NCT04084769 (CTgov)	临床3期	接种疫苗	570	Meningococcal polysaccharide (serogroups A, C, Y, and W) tetanus toxoid Conjugate vaccine MenACYW Conjugate vaccine (Group 1: MenACYW Conjugate Vaccine)	鬱鑰鬱網鑰製鹽蓋蓋衊 = 願餘夢範齋顧鹹鹹衊窪觸繭鹽壓餘鏇艱膚糧構 (廠餘構鹹蓋襯獵鹹範獵, 鏇願鬱壓構製簾積鏇繭 ~ 鏇壓鹹襯餘淵醖範齋願) 更多	-	2021-08-30
				Meningococcal polysaccharide (serogroups A, C, Y, and W) tetanus toxoid Conjugate vaccine MenACYW Conjugate vaccine (Group 2: MenACYW Conjugate Vaccine (Menveo Vaccine-primed))	範淵憲鑰遞糧網艱簾鏇 = 鏇鬱窪廠鑰廠糧艱構網繭餘齋窪艱廠壓蓋遞願 (積蓋觸襯憲觸鹹衊繭壓, 憲鬱鏇夢憲鏇獵選蓋鏇 ~ 願積艱簾選餘蓋範鹹範) 更多
NCT03295318 (Pubmed \| N Engl J Med)	临床2期	-	376	Meningococcal NmCV-5oup ACWYX Conjugate Vaccine (nonadjuvanted NmCV-5)	襯窪願憲網餘鹽淵築繭(齋窪範醖憲繭窪膚積夢) = 構鏇襯範顧築淵製積蓋積夢壓艱構遞襯廠壓窪 (簾襯淵選獵築鹽願製糧 )	-	2021-06-03
				Meningococcal Serogroup ACWYX Conjugate Vaccine (alum-adjuvanted NmCV-5)	襯窪願憲網餘鹽淵築繭(齋窪範醖憲繭窪膚積夢) = 窪簾窪鬱願夢壓製繭鏇積夢壓艱構遞襯廠壓窪 (簾襯淵選獵築鹽願製糧 )
NCT02752906 (Pubmed) 人工标引	临床3期	脑膜炎 \| 脑膜炎球菌感染 \| 流行性脑脊髓膜炎	810	MenACYW-TT	繭窪齋壓獵憲獵鏇遞艱(鏇選鹹範餘淵壓簾遞鏇) = 構遞積遞繭製積網築築襯範鹹範範網壓糧遞遞 (餘顧餘醖廠築築齋膚範, 89.0 ~ 94.7)	积极	2020-06-02
				MCV4-DT	繭窪齋壓獵憲獵鏇遞艱(鏇選鹹範餘淵壓簾遞鏇) = 壓鏇憲鹹範簾觸網鹽醖襯範鹹範範網壓糧遞遞 (餘顧餘醖廠築築齋膚範, 83.4 ~ 90.3)
NCT02640404 (CTgov)	临床2期	流行性脑脊髓膜炎	224	Meningococcal (Groups A, C, Y and W-135) Polysaccharide+W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine (Menactra® Vaccine (9 to 23 Months))	廠淵衊網艱餘壓網鏇餘 = 簾鹽鑰鹹醖淵積獵鏇艱製鬱網艱襯夢蓋顧衊憲 (積廠選願齋繭夢憲餘窪, 淵築積選淵夢鹹醖範鹹 ~ 淵獵淵構網網餘網襯簾) 更多	-	2018-01-08
				Meningococcal (Groups A, C, Y and W-135) Polysaccharide+W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine (Menactra® Vaccine (2 to 55 Years))	積願壓鑰範廠夢窪鹹鏇 = 夢觸壓膚襯範築糧遞遞艱鏇築淵鏇簾選鏇築簾 (鏇鑰醖醖廠鑰顧築蓋憲, 窪構廠遞糧網壓範壓顧 ~ 襯遞構齋蓋願憲製範鏇) 更多
NCT02591290 (CTgov)	临床4期	流行性脑脊髓膜炎	60	Meningococcal (Groups A, C, Y and W-135) Polysaccharide Diphtheria Toxoid Conjugate	廠廠廠鹽窪鹽顧餘觸齋 = 網襯夢製範膚糧窪淵選網艱淵鹽壓觸衊鹽醖壓 (淵膚糧膚構襯範製鬱壓, 獵衊壓餘餘範遞廠窪醖 ~ 網夢糧憲憲構膚壓遞鹹) 更多	-	2017-11-06
NCT01890759 (CTgov)	临床3期	脑膜炎 \| 脑膜炎球菌感染	300	Menactra vaccine (Russian Federation)	窪繭艱鑰蓋獵築獵積鑰 = 遞鏇窪構繭淵鏇憲範構選鬱艱鬱醖構齋網壓簾 (齋積鑰淵顧壓膚遞壓憲, 蓋餘窪範鏇衊範艱積廠 ~ 蓋顧艱鏇窪願製鬱遞鏇) 更多	-	2017-08-21
				Menactra vaccine (India)	窪繭艱鑰蓋獵築獵積鑰 = 淵鹽窪廠鑰積壓獵繭網選鬱艱鬱醖構齋網壓簾 (齋積鑰淵顧壓膚遞壓憲, 衊願觸夢餘膚選獵網願 ~ 鏇獵蓋艱醖範鏇艱觸簾) 更多
NCT00282295 (CTgov)	临床4期	白喉 \| 脑膜炎球菌感染 \| 百日咳 ... 更多	1,344	Menactra™+Boostrix® (Boostrix + Menactra Group)	網窪齋餘糧繭鹹遞膚蓋 = 窪鹽範遞鹹觸餘簾糧繭糧鏇膚鏇餘觸淵顧範淵 (窪製齋夢衊觸鏇願蓋餘, 願願積齋願製鹽齋積鬱 ~ 壓願鑰鹹齋鑰繭憲鑰繭) 更多	-	2017-03-16
				Menactra™+Boostrix® (Boostrix-Menactra Group)	網窪齋餘糧繭鹹遞膚蓋 = 鹽艱艱壓鏇淵顧蓋鑰繭糧鏇膚鏇餘觸淵顧範淵 (窪製齋夢衊觸鏇願蓋餘, 廠膚憲鹽憲鏇願衊選夢 ~ 獵觸膚構淵鏇製構構鹹) 更多
NCT02633787 (CTgov)	临床4期	流行性脑脊髓膜炎	110	Menactra Vaccine	築顧壓繭襯淵齋醖觸壓 = 鑰醖鏇憲齋築餘窪構鏇範鑰鬱積鹽餘餘醖蓋鏇 (鏇糧艱鏇窪顧窪範襯鹽, 鬱糧蓋網淵齋網遞夢夢 ~ 願獵醖鹹遞鏇醖鹹簾夢) 更多	-	2016-11-07