更新于：2024-11-04
Emedastine Difumarate
富马酸依美斯汀
更新于：2024-11-04
概要
基本信息
药物类型 小分子化药 |
别名 1-(2-Ethoxy-ethyl)-2-(4-methyl-[1,4]diazepan-1-yl)-1H-benzoimidazole、1-(2-ethoxyethyl)-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)benzimidazole、1-[2-(ethoxy)ethyl]-2-(4-methyl-1-homopiperazinyl)benzimidazole + [19] |
作用机制 H1 receptor拮抗剂(组胺H1受体拮抗剂) |
非在研适应症- |
原研机构 |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C25H34N4O9 |
InChIKeyFWLKKPKZQYVAFR-LVEZLNDCSA-N |
CAS号87233-62-3 |
关联
15
项与 富马酸依美斯汀 相关的临床试验富马酸依美斯汀缓释胶囊（2mg）在中国健康受试者中空腹和餐后给药条件下随机、开放、单剂量、两序列、两周期、双交叉生物等效性试验
Long Term Efficacy of Artemisia Pollen Specific Allergen Immunotherapy in Patients With Seasonal Allergic Rhinitis
Single dose pharmacokinetic study of HP-3060 in pediatric patients with allergic rhinitis (2)
100 项与 富马酸依美斯汀 相关的临床结果
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100 项与 富马酸依美斯汀 相关的转化医学
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100 项与 富马酸依美斯汀 相关的专利（医药）
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226
项与 富马酸依美斯汀 相关的文献（医药）2024-02-28Biological & pharmaceutical bulletin
Emedastine Inhibits Th1 and Th2 Cell Differentiation Mediated by Mast Cells
Article
作者: Kuroki, Akari ; Morishima, Aya ; Matsui, Katsuhiko
We have previously clarified that emedastine, a second-generation antihistamine drug, inhibits T helper 1(Th1)/Th2 cell differentiation mediated by Langerhans cells (LCs). In addition, although we have recently found that mast cells also function as antigen-presenting cells (APCs) and induce Th1/Th2 cell differentiation, any influence of emedastine on this function remained unclear. Here we investigated the influence of emedastine on Th1/Th2 cell differentiation via mast cells. Mast cells were obtained by long-term culture of murine splenocytes in medium supplemented with tumor necrosis factor (TNF)-α. The mast cells were then incubated in the presence or absence of emedastine, and cultured with naïve CD4+ T cells in the presence of ovalbumin (OVA) peptide. Five days later, Th cells in the culture were stimulated with phorbol 12-myristate 13-acetate (PMA) and ionomycin, and Th1/Th2 cytokine production was examined by enzyme-linked immunosorbent assay. When mast cells treated with emedastine were used as APCs, production of interferon (IFN)-γ and interleukin (IL)-4 from activated Th cells was significantly suppressed. This suppression was associated with inhibition of CD86 expression on mast cells, and mast cells treated with emedastine were shown to obstruct the differentiation of both Th1 and Th2 cells by down-regulating their cell surface expression of CD86. The present data provide additional information that topical application of emedastine to the lesional skin of patients with atopic dermatitis (AD) would reduce not only LC- but also mast cell-mediated skin inflammation.
2024-01-01Journal of hazardous materials
A photoluminescence strategy for detection nanoplastics in water and biological imaging in cells and plants
Article
作者: Zhou, Yanmei ; Wu, Tian ; Ning, Juan ; Yang, Jialu ; Hu, Guizhen
Nanoplastics exposure poses a significant threat to the environment and human health, and accurate measurement of nanoparticles in aqueous solutions remains challenging. In this work, we synthesized the cationic fluorescent probe 4-[1-Cyano- 2-[4-(Diethylamino)-2-hydroxyphenyl]ethenyl]-1-ethylpyridinium (PCP) through a straightforward procedure for the rapid and accurate detection and labeling of nanoplastics in aqueous solutions. PCP binds to nanoplastics through electrostatic and hydrophobic interactions with restricted intramolecular rotation and exhibits enhanced fluorescence emission. Using carboxylation-modified polystyrene nanoplastics as a model, PCP could accurately detect concentrations as low as 0.525 mg∙L-1 in aqueous solution and perform wash-free semi-quantitative direct observation. The method demonstrated good reproducibility and recovery in actual sample spiking experiments. In addition, PCP-labeled nanoplastics were successfully used to visualize the uptake and distribution of cells and Arabidopsis thaliana when exposed to different concentrations of nanoplastics. This work provides a simple and sensitive method for efficiently identify, track, and quantify nanoplastics without requiring additional pretreatment and complex instrumentation, making it an ideal tool for accurately quantifying nanoplastics in aqueous solutions and studying the biological interactions of nanoplastics.
2023-08-01Biochemical genetics
Identification of lncRNA-miRNA-mRNA Regulatory Network and Therapeutic Agents for Skin Aging by Bioinformatics Analysis
Article
作者: Liao, Yangying ; Hu, Feng ; Li, Ke ; Feng, Hao ; Xiao, Xiao ; Tang, Hua ; Li, Lan
Skin aging is the most intuitive manifestation of aging. Skin aging inevitably leads to cosmetic and psychological problems, and even diseases. The present study aims to research the pathological and molecular mechanisms underlying skin aging and identify the therapeutic agents for reversing skin aging. Two available gene expression datasets (GSE55118 and GSE72264) for skin aging were downloaded from Gene Expression Omnibus, followed by bioinformatic analyses performed on the datasets. Firstly, 169 crucial mRNAs, 27 crucial miRNAs and 50 crucial lncRNAs closely related to skin aging were identified by weighted gene co-expression network analysis. Then, function Enrichment Analysis performed by Metascape database showed that skin aging involves a variety of biological functions, such as detection of stimulus, response to steroid hormone and water channel activity, regulation of muscle contraction. Next, ten hub genes including AQP4, TRPM8, TBR1, NTSR2, MPPED1, BARHL2, PAX9, CPN1, CES3, and CHGB were screened out by the protein-protein interaction analysis. Next, the "lncRNA-miRNA-mRNA" network and the "lncRNA-miRNA-hub mRNA" network were constructed to explore the competing endogenous RNAs mechanism of skin aging. Finally, ten significant potential small molecules mitigating skin aging were screened using CMAP platform, including tretinoin, pifithrin, selamectin, entinostat, bretazenil, syringic-acid, BRD-K96475865, emedastine, abacavir, and rotenone, and their reliability was verified by molecular docking experiments. The present study provided basis for revealing the molecular mechanism of skin aging and identified the potential candidate drugs for mitigating skin aging.
100 项与 富马酸依美斯汀 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 季节性过敏性结膜炎 | 欧盟 | 1999-01-27 | |
| 季节性过敏性结膜炎 | 冰岛 | 1999-01-27 | |
| 季节性过敏性结膜炎 | 列支敦士登 | 1999-01-27 | |
| 季节性过敏性结膜炎 | 挪威 | 1999-01-27 | |
| 湿疹 | 日本 | 1996-09-09 | |
| 瘙痒 | 日本 | 1996-09-09 | |
| 变应性结膜炎 | - | 1993-01-01 | |
| 皮炎 | - | 1993-01-01 | |
| 特应性皮炎 | - | 1993-01-01 | |
| 过敏性鼻炎 | - | 1993-01-01 | |
| 荨麻疹 | - | 1993-01-01 |
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