预约演示
更新于：2026-02-27
Amlodipine Besylate/Olmesartan Medoxomil
奥美沙坦酯氨氯地平
更新于：2026-02-27
概要
基本信息
药物类型 小分子化药 |
别名 Azor、Ol-Vamlo、Olmersartan medoxomil/amlodipine besilate + [6] |
作用方式 拮抗剂、阻滞剂 |
作用机制 AT1R拮抗剂(血管紧张素II-1型受体拮抗剂)、VDCCs阻滞剂(电压门控性钙通道复合体阻滞剂) |
治疗领域 |
非在研适应症- |
非在研机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (2007-09-26), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C29H30N6O6 |
InChIKeyUQGKUQLKSCSZGY-UHFFFAOYSA-N |
CAS号144689-63-4 |
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关联
50
项与 奥美沙坦酯氨氯地平 相关的临床试验CTR20252510
云鹏医药集团有限公司研制的奥美沙坦酯氨氯地平片（规格：20 mg/5 mg）与持证商为第一三共制药（上海）有限公司的奥美沙坦酯氨氯地平片（商品名：Sevikar®，20 mg/5 mg）在中国健康研究参与者中进行的随机、开放、单剂量、两周期、双交叉、空腹及餐后状态下的生物等效性研究
CTR20244099
山西同达药业有限公司研制的奥美沙坦酯氨氯地平片（规格：20 mg/5 mg）与持证商为第一三共制药（上海）有限公司的奥美沙坦酯氨氯地平片（商品名：Sevikar®，20 mg/5 mg）在中国健康受试者中进行的随机、开放、单剂量、两周期、双交叉、空腹及餐后状态下的生物等效性研究
CTR20242837
奥美沙坦酯左氨氯地平片(20mg/2.5mg)用于奥美沙坦酯片(20mg)或苯磺酸氨氯地平片(5mg)单药治疗4周血压不能有效控制的原发性轻、中度高血压患者的有效性和安全性的随机、双盲双模拟、多中心Ⅲ期临床研究
100 项与 奥美沙坦酯氨氯地平 相关的临床结果
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100 项与 奥美沙坦酯氨氯地平 相关的转化医学
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100 项与 奥美沙坦酯氨氯地平 相关的专利（医药）
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18
项与 奥美沙坦酯氨氯地平 相关的文献（医药）2023-12-12ACS nano
Azo Reductase Activated Magnetic Resonance Tuning Probe with “Switch-On” Property for Specific and Sensitive Tumor Imaging in Vivo
Article
作者: Song, Yang ; Tan, Weihong ; Li, Linyao ; Zhu, Xiaokang ; Li, Yu ; Song, Erqun ; Deng, Siyu ; Gu, Peilin
Cancer remains a threat to human health. However, if tumors can be detected in the early stage, then the effectiveness of cancer treatment could be significantly improved. Therefore, it is worthwhile to develop more sensitive and accurate cancer diagnostic methods. Herein, we demonstrated an azo reductase (AzoR)-activated magnetic resonance tuning (MRET) probe with a "switch-on" property for specific and sensitive tumor imaging in vivo. Specifically, Gd-labeled DNA1 (DNA1-Gd) and cyclodextrin-coated magnetic nanoparticles (MNP-CD) were employed as enhancer and quencher of MRET, respectively, while DNA2, an azobenzene (Azo) group-modified aptamer (AS1411), served as a linker between enhancer and quencher to construct the MRET probe of MNP@DNA(1-2)-Gd. In tumor tissues with high-level AzoR, the T1-weighted magnetic resonance signal of the MRET probe could be restored by intelligently regulating the switch from "OFF" to "ON" after activation with AzoR, thus accurately indicating the location of the tumor accurately. Moreover, the tumor with a 4 times smaller size than that of the normal tumor model could be imaged based on the proposed MRET probe. The as-proposed MRET-based magnetic resonance imaging strategy not only achieves tumor imaging accurately but also shows promise for early diagnosis of tumors, which might improve patients' survival rates and provide an opportunity for image-guided biomedical applications in the future.
2022-07-01Biophysical chemistry
Sulphonated azo dye decolorization by Alcaligenes faecalis subsp. phenolicus MB207: Insights from laboratory and computational analysis
Article
作者: Yasmin, Azra ; Basharat, Zarrin
Microbial decolorization of azo dyes, mediated by an enzymatic mechanism is an intricate cost-effective, and eco-friendly treatment method of genotoxic azo pollutants. Scientists are on the constant lookout for microbes, enzymes, and mechanisms that could aid remediation of the environment at a fast pace. Alcaligenes faecalis subsp. phenolicus MB207 is one such bacteria, consisting of azoreductase (AzoR) and laccase/multicopper oxidase enzyme responsible for sulphonated mono-azo dye (Methyl orange) and di-azo dye (Congo red) degradation. AzoR degrades dyes by a ping-pong setup while multicopper oxidase achieves this through a non-specified radical approach. We have coupled experimental analysis with bioinformatics for deciphering intricacies of this procedure in tiny scale enzymatic machines of this biotope. The degradation assays were followed by molecular docking of the enzyme-substrate complexes. Key anchoring bonds were detected and mapped H-bonding, electron exchange, ionic interactions, as well as hydrophobic interactions, provided insights into dye-enzyme and NADH-enzyme binding. This study establishes a foundation of the molecular basis of dye interaction with azoR and multicopper oxidase in A. facealis subsp. phenolicus MB207.
2021-08-12The Journal of antimicrobial chemotherapy2区 · 医学
Role of AzoR, a LysR-type transcriptional regulator, in SmeVWX pump-mediated antibiotic resistance in Stenotrophomonas maltophilia
2区 · 医学
Article
作者: Lin, Yi-Tsung ; Yang, Tsuey-Ching ; Tsai, Yu-Chieh ; Li, Li-Hua ; Lu, Hsu-Feng
Abstract:
Background:
The SmeVWX efflux pump of Stenotrophomonas maltophilia contributes to menadione (MD) tolerance and resistance to chloramphenicol, quinolones and tetracycline. The components of the SmeVWX efflux pump are encoded by a five-gene operon, smeU1VWU2X. We have previously demonstrated that the smeU1VWU2X operon is intrinsically unexpressed and inducibly expressed by MD via a SoxR- and SmeRv-involved regulatory circuit in S. maltophilia KJ. We also inferred that there should be other regulator(s) involved in MD-mediated smeU1VWU2X expression in addition to SoxR and SmeRv.
Objectives:
To identify novel regulator(s) involved in the regulation of MD-mediated smeU1VWU2X expression and elucidate the regulatory circuit.
Methods:
A possible regulator candidate involved in the regulation of MD-mediated smeU1VWU2X expression was identified by a homologue search using the helix-turn-helix domain of SmeRv as a query. Gene expression was assessed using the promoter-xylE transcriptional fusion assay and quantitative RT–PCR. The impact of the regulator on SmeVWX pump-mediated functions was investigated via mutant construction and functional tests (antibiotic susceptibility and MD tolerance).
Results:
AzoR (Smlt3089), a LysR-type transcriptional regulator, was investigated. In unstressed logarithmically grown cells, AzoR was abundantly expressed and functioned as a repressor, inhibiting the expression of the smeU1VWU2X operon. MD challenge attenuated azoR expression, thus derepressing the expression of the smeU1VWU2X operon in S. maltophilia KJ. AzoR down-regulation-mediated smeU1VWU2X expression was observed in quinolone-resistant and SmeVWX-overexpressing S. maltophilia clinical isolates.
Conclusions:
AzoR negatively regulates the expression of the smeU1VWU2X operon and SmeVWX pump-mediated antibiotic resistance in S. maltophilia.
100 项与 奥美沙坦酯氨氯地平 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 原发性高血压 | 中国 | 2018-07-12 | |
| 高血压 | 美国 | 2007-09-26 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床4期 | 600 | Olmesartan/Amlodipine 40/10 mg | 繭觸遞窪夢憲顧鏇膚蓋(窪夢廠觸顧製膚廠範獵) = 鹽積遞獵淵鑰鏇製蓋範 窪鏇夢淵簾憲願鑰範簾 (顧鬱衊餘鏇衊網鏇艱廠 ) 更多 | 积极 | 2013-12-01 | ||
Perindopril/Amlodipine 8/10 mg | 繭觸遞窪夢憲顧鏇膚蓋(窪夢廠觸顧製膚廠範獵) = 廠鏇簾範獵齋膚醖憲鑰 窪鏇夢淵簾憲願鑰範簾 (顧鬱衊餘鏇衊網鏇艱廠 ) 更多 | ||||||
N/A | 292 | 壓遞選獵鹹艱積顧選獵(齋選願獵淵餘蓋窪膚繭) = Incidence of study drug related adverse events was comparable in monotherapy and combination therapy group (2.77% vs 2.17%) 艱糧觸蓋繭選窪範遞夢 (鑰膚鹽鏇構鏇廠夢餘壓 ) | 积极 | 2012-09-01 | |||
临床3期 | 2,204 | (Olmesartan(OLM) 40 Mg-Amlodipine(AML) 10 mg) | 繭獵窪窪製壓觸鏇網範(夢鑰積積願壓簾艱簾繭) = 襯鬱選顧獵鹽構淵鏇鑰 壓顧鹽憲衊衊選顧艱壓 (齋餘遞糧壓窪鏇壓齋夢, 0.55) 更多 | - | 2011-11-22 | ||
(OLM 40-AML 10-Hydrochlorothiazide (HCTZ) 12.5) | 繭獵窪窪製壓觸鏇網範(夢鑰積積願壓簾艱簾繭) = 構壓鏇齋製簾鏇襯鑰衊 壓顧鹽憲衊衊選顧艱壓 (齋餘遞糧壓窪鏇壓齋夢, 0.55) 更多 | ||||||
临床4期 | 999 | Hydrochlorothiazide+Amlodipine+Olmesartan Medoxomil | 襯壓範構憲構蓋範襯製 = 鏇窪糧簾築顧構鏇繭憲 壓衊願積夢範築獵構構 (壓鬱醖鑰壓蓋願鏇蓋簾, 糧顧獵繭網壓鑰壓蓋鹽 ~ 繭網獵鏇網築獵築夢鬱) 更多 | - | 2010-09-29 | ||
临床4期 | 207 | 遞襯廠積構遞艱願憲齋(願鑰淵艱選淵膚觸簾鏇) = 積積蓋獵積積遞餘顧鬱 製窪網築壓艱鏇鏇築鹹 (衊鏇糧窪鏇顧壓鹹築艱, 0.76) 更多 | - | 2010-07-02 |
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