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Roche, pipeline bulging from deal spree, axes 8 oncology and neurology programs to speed up R&D

2024-02-01

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Roche’s clear-out was accompanied by an influx of other assets.

Roche has removed eight phase 1 and 2 oncology and neurology candidates from its pipeline as part of a set of “trade-offs” intended to “increase the overall portfolio value and speed up development.”

Rochee fourth quarter (PDF), Roche removed eight drug candidates and replaced them with eight different prospects, shifting the balance of its pipeline away from neurology and, to a lesser extent, oncology and toward immunology, cardiovascular and metabolism in the process. The number of neurology prospects fell from 18 to 12, although one of those was moved to another part of the pipeline.

CEO Thomas Schinecker said thRoche resources will be shifted "to projects we want to accelerate." He also foreshadowed similar pipeline cuts to come in the first quarter during a fourth quarter earnings call Thursday.

Basmisanil is one of the candidates Roche is kicking to the curb. The drugmaker trialed the GABAA α5 receptor negative allosteric modulator in ischemic stroke and schizophrenia patients from 2016 to 2019. The discovery of an EEG biomarker of dup15q, a developmental disorder, spurred interest in treating the syndrome by reducing GABA activity in the brain and led Roche to start enrolling patients in a phase 2 trial in 2022. ClinicalTrials.gov lists the study as recruiting, but Roche removed the asset from its pipeline.

Basmisanil axed balovaptan, a small-Rocheule vasopressin V1A receptor antagonist that previously made it to phnegative allosteric modulatorrderischemic strokeo movschizophrenia The drugmaker tried again in the aftermath of the failure, kickindup15qa phdevelopmental disorderaumatic stress disorder. Roche finished that trial last year and promptly removed balovaptaRochem its pipeline.Roche

Rocheof the othebalovaptany changes preceded the fourth-quarter update. AC Immune said Roche had returned the Alzheimerautism spectrum disordernezumab and semorinemab last month, and details of the decision to drop Angelman syndrome candidate rugonersen emerged via tpost-traumatic stress disorder.Roche balovaptan

On the oncology side, Roche removed three phase 1 candidates from the piAC Immunehe druRocher dealt a second bAlzheimer’s disease treating screnezumabs by semorinemabAP. Having already stopped studying a FAP-IL-2v cAngelman syndromeemoved the solid tumor FAP-CD40 prospect RG6189 from its pipeline in the fourth quarter. A phase 1b trial of a FAP-4-1BBL candidate, RG7827, is continuing.

The other two axed oncRoche assets are the EGFRvIIIxCD3 bispecific antibody RG6156, which Roche was studying in brain cancer, and another bsolid tumorssigned to bindFAP HLA-G on tumor cells and CD3 on T cells.Roche solid tumor RG6189 FAP-4-1BBL RG7827

Roche’s clear-out was accompanied by an influx of other assets, including caRG6156es acquiRochehrough the takeovbrain cancert Therapeutics and Telavant. A longer-term beHLA-Givertumorclinical caCD3date, too, with Roche moving a covalent inhibitor of WRN, the synthetic lethal target at the heart of a $135 million deal with Vividion Therapeutics, into phase 1.

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