Objective: To investigate the compatibility stability of caffeine citrate injection with three commonly used injections.Methods: The caffeine citrate injection was mixed with 5% glucose injection, 0.9% sodium chloride injection or 10% calcium gluconate injection, resp. and the mixtures were kept at room temperatureTheir properties, pH value, osmolality, and insoluble particles were investigated at 0 min, 10 min, 30 min, and 24 h after mixture, resp. and the contents of the related substances, caffeine and 5-hydroxymethylfurfural in 5% glucose injection were determined by high performance liquid chromatog.Results: Under the above-mentioned conditions, the properties, pH value, osmotic pressure, insoluble particles, related substances and the other contents showed no significant change.Conclusion: The caffeine citrate injection being compatible with 5% glucose injection, 0.9% sodium chloride injection or 10% calcium gluconate injection is stable and safe within 24 h.