更新于：2024-11-04
Bromhexine Hydrochloride
盐酸溴己新
更新于：2024-11-04
概要
基本信息
原研机构 |
在研机构 |
非在研机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评孤儿药 (美国) |
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结构
分子式C14H21Br2ClN2 |
InChIKeyUCDKONUHZNTQPY-UHFFFAOYSA-N |
CAS号611-75-6 |
关联
37
项与 盐酸溴己新 相关的临床试验盐酸溴己新片在健康研究参与者中的单剂量、随机、开放、交叉、两周期空腹和餐后人体生物等效性试验
Fasted-state in vivo bioequivalence study of Bromhexine 8 mg tablet manufactured by AaniDarman compared with innovator product
盐酸溴己新颗粒在中国成年健康受试者中的一项随机、开放、空腹单次给药、两制剂、两序列、两周期交叉的生物等效性试验
100 项与 盐酸溴己新 相关的临床结果
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100 项与 盐酸溴己新 相关的转化医学
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100 项与 盐酸溴己新 相关的专利（医药）
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516
项与 盐酸溴己新 相关的文献（医药）2024-12-01JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
Bidentate bromhexine drug coordination modes with various transition metal ions: Synthesis, characterization, and in vitro antibacterial and anti-breast cancer activity tests
Article
作者: Mahmoud, Nessma Fathi ; Omar, Norhan Refaie ; Sayed, Fatma Nabil ; Mohamed, Gehad Genidy
BACKGROUND:
Bromhexine (BHX) is a mucolytic drug used in treatment the respiratory disorders which are associated with excessive or viscid mucus. Transition metal complexes have made tremendous progress in the treatment of a variety of human ailments, according to reported articles. Transition metal complexes are being developed as medications with a lot of effort. Metal complexes can form a variety of coordination geometries, giving them distinct forms. So, binary metal complexes of bromhexine drug have been prepared to enhance the biological activity and stability of the free drug.
METHODS:
A new series of binary complexes with bromhexine drug (BHX) has been prepared with some transition metal ions namely Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), and Cd(II). Elemental analyses, FT-IR, mass spectrometry, thermal studies and UV-Vis spectra have been used to characterize and structurally elucidate the produced metal complexes. Antibacterial activity has been tested for the ligand and metal complexes against a variety of pathogenic bacterial species (Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus). In addition, the ligand has been tested for anticancer efficacy against the MCF-7 breast cancer cell line, as opposed to binary metal complexes. The binding orientation or conformation of the free BHX ligand and Co(II) complex in the active region of the protein of crystal structure of Escherichia coli (PDB ID: 3T88) and Pseudomonas aeruginosa (PDB ID: 6NE0) has been performed using molecular docking studies.
RESULTS:
The BHX ligand coupled in neutral bidentate mode to the metal ions, according to FT-IR and 1H-NMR spectral results. The molar conductivity measurements of the complexes in DMF proved the electrolytic nature of all binary complexes. Co(II) complex showed the highest inhibition zone diameter against S. aureus, E. coli and P. aeruginosa. Zn(II) complex had the greatest inhibitory effect against P. aeruginosa and B. subtilis. Also, Cd(II) chelate appeared high efficacy as antibacterial agent against Pseudomonas aeruginosa and Staphylococcus aureus.
CONCLUSION:
All the output data conjugated to confirm the octahedral geometry of the metal complexes. The biological findings revealed that metal complexes can be more active than the free BHX ligand. Against MCF-7 cell line, Cd(II)-L complex is highly active complex (4.95 µg/mL) but BHX free drug is the most active compound (3.96 µg/mL).
2024-09-01JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
A drug–excipient interaction impurity of bromhexine hydrochloride injection: Structure and formation mechanism elucidation
Article
作者: Zhou, Min ; Chen, Feng ; Wu, Wei ; Pu, Hong ; Long, Yuande ; Yi, Chaofan
A long-term stability study using high performance liquid chromatography (HPLC) revealed an unidentified impurity in the bromhexine hydrochloride injection, which was employed as a mucolytic agent. Investigations into stress degradation and elemental impurities revealed one of the elemental impurities Fe3+ in this injection as the primary generator of these impurities. This impurity, named N-carboxymethyl bromhexine, was a product formed during drug-excipient interaction between bromhexine and tartaric acid with Fe3+. The structure of the impurity was identified through ultra-high-performance liquid chromatography with diode array detector (UHPLC-DAD), liquid chromatograph mass spectrometer (LC-MS). Further, the formation mechanism of the impurity was discussed. Overall, this study elucidates the cause, origin, and mechanism of an unknown impurity in bromhexine hydrochloride injection, providing a basis for quality control for bromhexine hydrochloride injections and drug products containing both amine and tartaric acid.
2024-09-01LIFE SCIENCES
Beyond the lungs: Exploring diverse applications of bromhexine and ambroxol
Review
作者: Ohadi, Mohammad Amin Dabbagh ; Soltani, Zahra Ebrahim ; Dehpour, Ahmad-Reza ; Afrooghe, Arya ; Ahmadi, Elham ; Shayan, Maryam ; Elahi, Mohammad
The respiratory tract is commonly affected in multisystem disorders. Although many drugs have been developed to target various components of these diseases, there is still a need for effective treatments that can address both respiratory and non-respiratory symptoms. Bromhexine and ambroxol are mucolytic agents with a good safety profile that are widely used to treat respiratory conditions. These compounds seem to present several unresolved questions when carrying out their therapeutic effects, suggesting that they may not merely improve mucociliary clearance. These assumptions have provided the basis for researchers to investigate the specific characteristics of bromhexine and ambroxol. This has led to the emergence of several repositionings for this compound. Accordingly, these compounds have also shown potential benefits in the treatment of various extrapulmonary disorders, including neurological disorders, and inflammatory bowel disease. We gathered findings from relevant studies published in English between 1970 and December 2023 by searching databases including PubMed, Google Scholar, Scopus, Embase, and the Cochrane Library. Our findings revealed that most of the research on extrapulmonary uses has been conducted at the preclinical level. Accordingly, more clinical studies are needed to determine the effectiveness of bromhexine and ambroxol in these conditions. This article provides an overview of the potential extrapulmonary applications of bromhexine and ambroxol and discusses the potential advantages of using these drugs in multisystem disorders.
100 项与 盐酸溴己新 相关的药物交易
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 急性鼻窦炎 | 临床3期 | 中国 | 2021-07-06 | |
| 慢性支气管疾病 | 临床3期 | 中国 | 2021-07-06 | |
| 慢性鼻窦炎 | 临床3期 | 中国 | 2021-07-06 | |
| 下呼吸道感染 | 临床3期 | 中国 | 2021-07-06 | |
| 气管支气管炎 | 临床3期 | 中国 | 2021-07-06 | |
| 支气管扩张 | 临床3期 | 中国 | 2021-04-07 | |
| 支气管肺炎 | 临床3期 | 中国 | 2021-04-07 |
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临床结果
临床结果
适应症
分期
评价
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临床4期 | 50 | (Control Group) | 繭獵廠構構觸網憲艱窪(淵積獵鑰選製構鬱簾鹹) = 糧廠繭遞範淵廠餘簾繭 鹽構廠範觸繭膚網製窪 (襯簾網鹹糧構鹽遞築構, 糧夢蓋簾簾選廠蓋憲餘 ~ 鹹鏇壓廠簾顧鹹網鹹壓) 更多 | - | 2022-04-13 | ||
(Bromhexine Hydrochloride Group) | 壓淵艱鏇憲鏇選鏇壓齋(鏇範齋築獵獵繭廠鑰糧) = 憲網鬱繭夢繭積鹽壓衊 醖壓憲憲鬱艱淵衊齋簾 (鑰齋艱憲願憲願艱鹹繭, 遞廠積鹽構選窪餘構觸 ~ 鑰選鹹齋廠範顧願積糧) 更多 |
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