Delving into the Latest Updates on Sam OH Pharm Co. Ltd. with Synapse

Agaricus bisporus Extract Exerts an Anti-Obesity Effect in High-Fat Diet-Induced Obese C57BL/6N Mice by Inhibiting Pancreatic Lipase-Mediated Fat Absorption

作者: Jeon, Young-Eun ; Jung, Jae-In ; Ko, Donghyeon ; Kim, Hyungkeun ; Kim, So-Mi ; Kim, Eun-Ji

Agaricus bisporus is well known as a source of polysaccharides that could improve human health.The objective of this study was to explore the anti-obesity effect of A. bisporus extract (ABE), abundant in polysaccharides, and its underlying mechanism.Pancreatic lipase inhibitory activity in vitro was determined after treatment with ABE and chitosan.Treatment with ABE and chitosan significantly decreased pancreatic lipase activity.Five-week-old male SD rats were randomly divided into three groups for acute feeding with vehicle, ABE at 80 mg/kg body weight (BW)/day, and ABE at 160 mg/kg BW/day.ABE dose-dependently increased plasma lipid clearance in an oral lipid tolerance test.Five-week-old male C57BL/6N mice were fed a control diet (CD), a high-fat diet (HFD), an HFD with ABE at 80 mg/kg BW/day, ABE at 160 mg/kg BW/day, or chitosan at 160 mg/kg BW/day for eight weeks.HFD-fed mice showed significant increases in body weight, fat mass, white adipose tissue, average lipid droplet size, and serum levels of glucose, triglyceride, ALT, and AST compared to those in the CD group.However, ABE or chitosan administration ameliorated these increases.ABE or chitosan significantly reduced dietary efficiency and increased fecal excretion levels of lipids, triglycerides, and total cholesterol.These in vitro and in vivo findings suggest that ABE might act as an anti-obesity agent by inhibiting pancreatic lipase-mediated lipid absorption, at least in part.

Nutrients

Agaricus bisporus Extract Exerts an Anti-Obesity Effect in High-Fat Diet-Induced Obese C57BL/6N Mice by Inhibiting Pancreatic Lipase-Mediated Fat Absorption

Article

作者: Kim, Eun-Ji ; Ko, Donghyeon ; Jung, Jae-In ; Jeon, Young-Eun ; Kim, Hyungkeun ; Kim, So-Mi

Agaricus bisporus is well known as a source of polysaccharides that could improve human health. The objective of this study was to explore the anti-obesity effect of A. bisporus extract (ABE), abundant in polysaccharides, and its underlying mechanism. Pancreatic lipase inhibitory activity in vitro was determined after treatment with ABE and chitosan. Treatment with ABE and chitosan significantly decreased pancreatic lipase activity. Five-week-old male SD rats were randomly divided into three groups for acute feeding with vehicle, ABE at 80 mg/kg body weight (BW)/day, and ABE at 160 mg/kg BW/day. ABE dose-dependently increased plasma lipid clearance in an oral lipid tolerance test. Five-week-old male C57BL/6N mice were fed a control diet (CD), a high-fat diet (HFD), an HFD with ABE at 80 mg/kg BW/day, ABE at 160 mg/kg BW/day, or chitosan at 160 mg/kg BW/day for eight weeks. HFD-fed mice showed significant increases in body weight, fat mass, white adipose tissue, average lipid droplet size, and serum levels of glucose, triglyceride, ALT, and AST compared to those in the CD group. However, ABE or chitosan administration ameliorated these increases. ABE or chitosan significantly reduced dietary efficiency and increased fecal excretion levels of lipids, triglycerides, and total cholesterol. These in vitro and in vivo findings suggest that ABE might act as an anti-obesity agent by inhibiting pancreatic lipase-mediated lipid absorption, at least in part.

100 项与 Sam OH Pharm Co. Ltd. 相关的药物交易

登录后查看更多信息

100 项与 Sam OH Pharm Co. Ltd. 相关的转化医学

登录后查看更多信息

组织架构

使用我们的机构树数据加速您的研究。

登录

或

查看完整样例数据

管线布局

2024年11月22日管线快照

管线布局中药物为当前组织机构及其子机构作为药物机构进行统计，早期临床1期并入临床1期，临床1/2期并入临床2期，临床2/3期并入临床3期

批准上市

8

登录后查看更多信息

当前项目

药物(靶点)	适应症	全球最高研发状态

加硫酶 ( ASB )	黏多糖贮积症VI型更多	批准上市
卡谷氨酸 ( CPS1 )	高氨血症更多	批准上市
依洛硫酸酯酶α ( GALNS )	黏多醣贮积症IV型更多	批准上市
无水甜菜碱	同型半胱氨酸尿症更多	批准上市
盐酸沙丙蝶呤 ( PAH )	苯丙酮尿症更多	批准上市