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Conference Call Scheduled for Wednesday, April 23 at 4:30 p.m. Eastern Time SAN DIEGO, April 16, 2025 /PRNewswire/ -- Viking Therapeutics, Inc. ("Viking") (NASDAQ: VKTX), a clinical-stage biopharmaceutical company focused on the development of novel therapies for metabolic and endocrine disorders, today announced that the company will release financial results for the first quarter 2025 after the market close on Wednesday, April 23, 2025. The company will host a conference call to discuss financial results and general corporate updates beginning at 4:30 p.m. Eastern Time on Wednesday, April 23, 2025. To participate on the conference call, please dial (844) 850-0543 from the U.S. or (412) 317-5199 from outside the U.S. In addition, following the completion of the call, a telephone replay will be accessible until April 30, 2025, by dialing (877) 344-7529 from the U.S. or (412) 317-0088 from outside the U.S. and entering replay access code #8779272. Those interested in listening to the conference call live via the internet may do so by visiting the Webcasts page of Viking's website at . An archive of the webcast will also be available on the Webcasts page of the company's website for 30 days. About Viking Therapeutics, Inc. Viking Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on the development of novel first-in-class or best-in-class therapies for the treatment of metabolic and endocrine disorders, with three compounds currently in clinical trials. Viking's research and development activities leverage its expertise in metabolism to develop innovative therapeutics designed to improve patients' lives. Viking's clinical programs include VK2735, a novel dual agonist of the glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptors for the potential treatment of various metabolic disorders. Data from a Phase 1 and a Phase 2 trial evaluating VK2735 (dosed subcutaneously) for metabolic disorders demonstrated an encouraging safety and tolerability profile as well as positive signs of clinical benefit. Concurrently, the company is evaluating an oral formulation of VK2735 in a Phase 2 trial. Viking is also developing VK2809, a novel, orally available, small molecule selective thyroid hormone receptor beta agonist for the treatment of lipid and metabolic disorders. The compound successfully achieved both the primary and secondary endpoints in a recently completed Phase 2b study for the treatment of biopsy-confirmed non-alcoholic steatohepatitis (NASH) and fibrosis. In a Phase 2a trial for the treatment of non-alcoholic fatty liver disease (NAFLD) and elevated LDL-C, patients who received VK2809 demonstrated statistically significant reductions in LDL-C and liver fat content compared with patients who received placebo. The company's newest program is evaluating a series of internally developed dual amylin and calcitonin receptor agonists (or DACRAs) for the treatment of obesity and other metabolic disorders. In the rare disease space, Viking is developing VK0214, a novel, orally available, small molecule selective thyroid hormone receptor beta agonist for the potential treatment of X-linked adrenoleukodystrophy (X-ALD). In a Phase 1b clinical trial in patients with the adrenomyeloneuropathy (AMN) form of X-ALD, VK0214 was shown to be safe and well-tolerated, while driving significant reductions in plasma levels of very long-chain fatty acids (VLCFAs) and other lipids, as compared to placebo. For more information about Viking Therapeutics, please visit . SOURCE Viking Therapeutics, Inc. WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

2025年3月，生物制药公司加速了在小分子药物、双特异性抗体和蛋白治疗药物等领域的药物开发。阿斯利康和诺和诺德是当月主要的合作伙伴，此外，相较于二月，并购也有所增加。本文将带您了解2025年3月生物技术和制药领域的一些重要交易。（图片来源：LABIOTECH）注：2025年3月，勃林格殷格翰和第一三共等制药巨头参与了并购和许可交易，但交易规模未被披露。3月生物制药大型公司的并购阿斯利康以高达10亿美元的价格收购了比利时生物技术公司EsoBiotec，这是当月生物制药领域的重要并购交易之一。EsoBiotec的ENaBL平台（EsoBiotec Engineered NanoBody Lentiviral平台）通过慢病毒载体将遗传指令传递给特定的免疫细胞（如T细胞），使其能够识别并摧毁癌细胞或自身免疫性疾病中的异常细胞。ENaBL平台的创新之处在于其体内（in vivo）治疗方式，能够通过简单的静脉注射实现，而无需传统细胞疗法所需的复杂体外细胞修改过程。这种技术不仅简化了治疗流程，还显著降低了治疗成本，并有望提高治疗的可及性和患者体验。阿斯利康的此次收购包括4.25亿美元的初始支付，以及基于开发和监管里程碑的额外5.75亿美元支付。交易预计将在2025年第二季度完成。百时美施贵宝（BMS）以2.86亿美元的价格启动了对美国生物技术公司2seventy bio的收购。根据新闻稿，BMS将发起一项要约收购，以每股5美元的全现金交易方式收购2seventy bio所有未发行的股份。两家公司多年来一直合作开发和商业化Abecma，这是一种用于治疗多发性骨髓瘤的CAR-T细胞疗法，于2021年获得美国FDA批准。赛诺菲（Sanofi）收购了总部位于加利福尼亚的抗体开发商Dren Bio的双特异性髓系细胞接合剂。临床候选药物DR-0201是一种抗体，它靶向并激活特定的髓系细胞——起源于骨髓的免疫细胞，通过靶向吞噬作用诱导深度B细胞耗竭，这是一种清除病原体和细胞碎片的机制。在研究中，它已显示出B细胞耗竭的效果。作为交换，赛诺菲将向Dren支付6亿美元的预付款，并在开发和上市里程碑基础上支付高达13亿美元的款项。在印度，太阳制药（Sun Pharma）以高达3.55亿美元的预付款和里程碑付款收购了美国生物技术公司Checkpoint Therapeutics。Checkpoint Therapeutics除了开发检查点抑制剂外，还开发了其他抗体。太阳制药将获得Checkpoint的抗PD-L1抗体cosibelimab，其品牌名为Unloxcyt，该药于2024年12月获得美国FDA批准，用于治疗晚期皮肤鳞状细胞癌（一种起源于鳞状细胞的皮肤癌）。根据协议，太阳制药将以每股4.10美元的现金支付方式收购Checkpoint的所有流通股，总预付款高达3.55亿美元。此外，Checkpoint的股东还将获得一项非可转让的或有价值权利（CVR），如果cosibelimab在欧洲获得批准，他们将有权获得每股额外0.70美元的现金支付，从而使交易总价值可能达到约4.16亿美元。太阳制药计划利用其全球影响力加速Unloxcyt的患者可及性。此次收购不仅将增强太阳制药在肿瘤-皮肤治疗领域的创新组合，还反映了其改善皮肤癌患者生活的承诺。日本制药公司Taiho收购了瑞士生物技术公司Araris，预付款和里程碑付款总额高达11.4亿美元。Araris是一家从瑞士保罗谢勒研究所（Paul Scherrer Institute）分拆出来的公司，专注于开发抗体-药物偶联物（ADCs）。这些ADCs将补充其癌症治疗产品线，其中包括小分子药物。此次收购将使Taiho获得Araris的创新ADC药物发现技术平台AraLinQ™，该平台通过其独特的技术开发的三种产品，目前处于临床前阶段，预计将在2025年至2026年间进入临床试验。（图片来源：LABIOTECH）3月交易热点领域2025年3月份制药巨头主要将目光聚焦于蛋白质疗法领域。美国制药巨头艾伯维（AbbVie）与丹麦生物技术公司Gubra达成了一项许可协议，共同开发GUB014295，这是一种潜在的长效胰淀素类似物，用于治疗肥胖症。GUB014295是一种特异性激活胰淀素和降钙素受体的激动剂，胰淀素是一种饱腹感激素，因其在激活大脑信号、抑制食欲和减少食物摄入中的作用，已被确定为治疗肥胖症的潜在治疗靶点。根据协议条款，艾伯维将主导GUB014295的全球开发和商业化活动。Gubra将获得3.5亿美元的预付款，并有资格获得高达18.75亿美元的开发、商业和销售里程碑付款，以及全球净销售额的分级版税。此次合作标志着艾伯维正式进入肥胖治疗领域。瑞士制药巨头罗氏（Roche）与丹麦肽类公司Zealand Pharma达成许可协议，共同开发肥胖治疗药物。该药物名为petrelintide，双方将共同开发并商业化，包括与罗氏的GLP-1/GIP受体双重激动剂CT-388等联合疗法。Zealand将获得16.5亿美元的预付款，并有资格获得高达12亿美元的开发里程碑付款（与petrelintide进入III期试验相关），以及24亿美元的销售里程碑付款。阿斯利康（AstraZeneca）除了以高达10亿美元收购比利时生物技术公司EsoBiotec外，还与元思生肽达成了一项许可协议，共同开发大环肽药物。大环肽是由氨基酸组成的短链分子，能够形成环状结构，具有独特的稳定性和靶向性。这些药物旨在治疗慢性疾病，包括罕见病、自身免疫疾病和代谢疾病。根据协议，元思生肽将获得7500万美元的预付款和近期支付款项，并有资格获得高达34亿美元的开发和商业化里程碑付款。这项合作将利用元思生肽的Synova™平台技术，开发针对多种疾病的大环肽药物管线。诺和诺德（Novo Nordisk）和马萨诸塞州初创公司Gensaic在蛋白质疗法领域展开合作。借助Gensaic的人工智能驱动的蛋白质设计技术和诺和诺德在治疗领域的专业知识，双方旨在开发用于治疗心脏和代谢疾病的药物候选。Gensaic有资格获得高达3.54亿美元的预付款、开发和商业里程碑付款。小分子药物是制药公司长期以来热点交易领域。默克（Merck）与恒瑞制药达成了一项交易，这是3月最大的小分子药物交易。该交易涉及恒瑞制药的一种口服脂蛋白（a）抑制剂，目前该药物正在中国进行II期临床试验。脂蛋白（a）是一种携带胆固醇、脂肪和蛋白质的蛋白质，当它们积累时，会形成类似于低密度脂蛋白胆固醇的斑块。抑制剂药物旨在防止这些斑块的形成，从而降低心脏病的风险。根据协议，默克将向恒瑞制药支付2亿美元的预付款，并在达到特定里程碑时支付高达17.7亿美元的款项。此前，默克在2025年2月与加拿大生物技术公司Epitopea达成协议，以识别肿瘤特异性抗原。诺和诺德（Novo Nordisk）与美国生物技术公司Lexicon达成了一项合作，共同开发小分子药物LX9851。LX9851是一种口服非肠促胰岛素类药物，用于治疗肥胖症及其他代谢紊乱。根据协议，诺和诺德将支付高达10亿美元，其中包括7500万美元的预付款和近期里程碑付款。此外，Lexicon还将获得基于开发、监管和销售的里程碑付款，以及LX9851净销售额的分级特许权使用费。诺华（Novartis）与日本制药公司杏林制药（Kyorin）达成合作，共同推进一款小分子药物KRP-M223的研发。KRP-M223是一种G蛋白偶联受体MRGPRX2的拮抗剂，该受体激活肥大细胞，这在慢性自发性荨麻疹等疾病中会发生，其特征是瘙痒的风团。KRP-M223旨在治疗这些疾病。根据协议，诺华公司获得了KRP-M223的全球独家开发、生产和商业化许可。杏林制药保留了在日本商业化和为日本市场生产该产品的选择权。杏林制药将获得5500万美元的预付款，并有资格获得高达7.775亿美元的开发、批准和商业化里程碑付款，以及基于净销售额的分级特许权使用费。马萨诸塞州的Black Diamond Therapeutics与法国生物技术公司Servier达成了一项合作，共同开发靶向小分子药物BDTX-4933，用于治疗癌症。BDTX-4933是一种针对实体瘤中RAS突变和RAF改变的I期候选药物。根据协议，Black Diamond将获得7000万美元的预付款，并有资格获得高达7.1亿美元的里程碑付款。（图片来源：LABIOTECH）注：上述数据基于已披露财务条款的并购和许可交易（包括前期付款和里程碑付款）。除了蛋白质疗法领域、小分子领域以外双特异性抗体领域备也受瞩目。2025年3月，阿斯利康（AstraZeneca）与和铂医药达成了一项全球战略合作，旨在利用和铂医药的Harbour Mice®全人源抗体技术平台，发现和开发下一代多特异性抗体，用于治疗免疫学、肿瘤学等领域的疾病。根据协议，阿斯利康将获得两个临床前免疫学项目的许可选择权，并可指定进一步的靶点，供和铂医药发现下一代多特异性抗体。阿斯利康将有权将这些项目推进至临床开发阶段。作为合作的一部分，和铂医药将获得总计1.75亿美元的预付款和近期里程碑付款，以及高达44亿美元的额外开发和商业化里程碑付款，还有基于未来净销售额的分级特许权使用费。此外，阿斯利康还将对和铂医药进行1.05亿美元的股权投资，获得其9.15%的新发行股份。为了支持合作项目，和铂医药将在中国北京建立一个创新中心，与阿斯利康共同开展研发工作。此次合作不仅体现了阿斯利康对和铂医药技术平台的信心，也标志着和铂医药在多特异性生物制品创新领域的领先地位。通过结合和铂医药的前沿发现能力和阿斯利康的药物开发专长，双方旨在加速为未满足医疗需求的患者创造变革性疗法。瑞士制药巨头罗氏（Roche）与英国生物技术公司Oxford BioTherapeutics达成了一项合作，旨在利用Oxford BioTherapeutics的OGAP-Verify发现平台，开发用于治疗癌症的潜在FIC抗体疗法。OGAP-Verify平台是一种增强型专有发现平台，能够提高靶点识别的灵敏度，从而筛选出更适合药物开发的靶点。根据协议，Oxford BioTherapeutics将获得3600万美元的预付款，并有资格获得超过10亿美元的里程碑付款，以及基于净销售额的产品特许权使用费。罗氏将负责这些靶点的进一步研究、开发和商业化工作。日本制药公司推出RNA药物2025年3月，日本小野制药公司（Ono Pharmaceutical）与美国Ionis制药公司达成了一项独家许可协议，以获得后者针对真性红细胞增多症（PV）的RNA靶向疗法sapablursen的全球权利。sapablursen是一种配体结合反义（LICA）药物，旨在减少TMPRSS6的产生，从而增加铁调素的表达，为PV等血液病提供潜在的治疗益处。该疗法目前正在全面招募的II期IMPRSSION研究中进行评估。根据协议，小野制药将支付2.8亿美元的预付款，并根据开发、监管和销售里程碑的达成情况，额外支付最高可达6.6亿美元的款项。此外，小野制药还将按sapablursen年度净销售额的百分之十几向Ionis支付特许权使用费。Ionis将继续负责完成正在进行的II期IMPRSSION研究，而小野制药将全权负责后续的开发、监管申报和商业化工作。日本第一三共公司（Daiichi Sankyo）与美国Nosis Biosciences公司达成了一项合作，旨在利用Nosis的Connexa™平台开发用于治疗慢性疾病的RNA药物。该平台是一种先进的人工智能驱动的药物设计和递送系统，能够使RNA药物靶向关键器官中的多种细胞类型，从而改善慢性疾病的治疗选择。此次合作将利用该平台在人工智能药物设计、单细胞受体生物学和高通量化学方面的能力，以克服RNA疗法面临的递送挑战。Nosis的Connexa™平台通过整合人工智能驱动的药物设计、单细胞受体生物学和高通量化学，开发出针对体内使用的优化递送载体。该平台已经确定了532种细胞类型中的2900多个受体靶点，从而实现精准递送和优化的治疗效果。通过这次合作，预计将进一步推动多种疾病的精准RNA药物的研发进展。药物研发加速2025年3月，诺和诺德（Novo Nordisk）与联邦生物达成了一项独家许可协议，以获得后者开发的UBT251的全球权利。UBT251是一种GLP-1、GIP和胰高血糖素受体的三重激动剂，目前正处于临床早期试验阶段，用于治疗肥胖症、2型糖尿病及其他疾病。根据协议，诺和诺德将获得UBT251在全球范围内（不包括中国大陆、香港、澳门和台湾）的独家开发、生产和商业化权利。联邦生物将保留UBT251在中国大陆、香港、澳门和台湾的权利。联邦生物将获得2亿美元的预付款，并有资格获得高达18亿美元的潜在里程碑付款，以及基于净销售额的分级特许权使用费。德国制药巨头勃林格殷格翰（Boehringer Ingelheim）与瑞典生物技术公司Salipro Biotech达成了一项研究和许可协议，旨在加速多个药物靶点的开发。此次合作将利用Salipro的Salipro®平台技术，该技术能够稳定膜蛋白，使其保持其天然形式，从而用于药物发现项目。勃林格殷格翰将利用该技术进行生物物理和结构研究，包括冷冻电镜（cryoEM），以识别潜在的治疗候选药物。合作的重点是开发针对G蛋白偶联受体（GPCRs）、离子通道、转运蛋白及其他膜蛋白的疗法，这些靶点在心理健康和心肾代谢疾病等治疗领域具有重要意义。根据协议，Salipro Biotech将获得研究付款和选择权付款，并有资格获得基于勃林格殷格翰在合作中产生的开发结果的成功基础里程碑付款。英国医疗保健公司Hologen AI与美国生物技术公司MeiraGTx达成了一项战略合作，旨在加速MeiraGTx的AAV-GAD项目（用于治疗帕金森病）的III期临床试验。Hologen AI将提供2亿美元的预付款，并与MeiraGTx成立一家名为Hologen Neuro AI的合资企业，Hologen AI将为该合资企业提供高达2.3亿美元的承诺资本，用于全面资助AAV-GAD的开发直至商业化，以及推进其他早期临床项目，包括针对遗传性肥胖的AAV-BDNF项目。MeiraGTx将保留Hologen Neuro AI合资企业30%的所有权，并将领导所有临床开发和制造活动。此外，MeiraGTx还将与合资企业签订独家临床和商业制造供应协议。Hologen AI还将持有MeiraGTx制造子公司的少数股权，并将为该制造子公司提供年度资金支持，同时利用其AI技术优化MeiraGTx的专有制造能力。德国AI公司Partex与美国生物制药公司Fortress Biotech达成了一项战略合作，旨在利用人工智能技术识别和评估潜在的生物制药化合物，以供Fortress进行潜在的收购或许可，本次合作的财务条款未被披露。Partex将部署其专有的AI驱动药物发现和开发技术平台，该平台能够提供多样化的建议，包括跨治疗领域的靶点识别、适应症扩展和分子特征分析，从而加速创新疗法的开发。Fortress Biotech将利用Partex的AI平台，结合其在生物制药领域的专业知识和广泛的行业网络，快速识别和评估有前景的生物制药资产。Fortress的业务模式专注于通过产品收入、股权持有以及股息和特许权使用费收入来提升股东的长期价值。此次合作预计将支持差异化资产的引进授权，双方都致力于在这一过程中最大限度地发挥AI的潜力。（图片来源：LABIOTECH）（图片来源：LABIOTECH）参考资料https://www.labiotech.eu/trends-news/top-biotech-deals-of-march-2025/其余素材来源官方媒体/网络新闻图片来源：123RF版权声明/免责声明本文为授权转载文章。本文仅作信息交流之目的，不提供任何商用、医用、投资用建议。文中图片、视频、字体、音乐等素材或为药时代购买的授权正版作品，或来自微信公共图片库，或取自公司官网/网络，部分素材根据CC0协议使用，版权归拥有者，药时代尽力注明来源。如有任何问题，请与我们联系。衷心感谢!药时代官方网站:www.drugtimes.cn联系方式:电话:13651980212微信:27674131邮箱:contact@drugtimes.cn点击这里，查看更多精彩!

13-Week Study Evaluating the Safety and Efficacy of Oral VK2735 Dosed Once Daily Results Expected in 2H25 SAN DIEGO, March 26, 2025 /PRNewswire/ -- Viking Therapeutics, Inc. ("Viking") (NASDAQ: VKTX), a clinical-stage biopharmaceutical company focused on the development of novel therapies for metabolic and endocrine disorders, today announced the completion of subject enrollment in its Phase 2 clinical trial of the oral tablet formulation of VK2735, the company's dual agonist of the glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptors. VK2375 is being developed in both oral and subcutaneous formulations for the potential treatment of various metabolic disorders such as obesity. Viking expects to report data from the study in the second half of 2025. The Phase 2 VENTURE-Oral Dosing Trial is a randomized, double-blind, placebo-controlled multicenter study designed to evaluate the safety, tolerability, pharmacokinetics and weight loss efficacy of VK2735 dosed as an oral tablet once daily for 13 weeks. The trial enrolled approximately 280 adults who are obese (BMI ≥30 kg/m2), or adults who are overweight (BMI ≥27 kg/m2) with at least one weight-related co-morbid condition. Enrolled patients have been evenly randomized to one of six dosing arms or placebo. The primary endpoint of the study is the percent change in body weight from baseline after 13 weeks of treatment. Secondary and exploratory endpoints will evaluate a range of additional safety and efficacy measures. "As with our previous Phase 2 study of subcutaneous VK2735, interest in participating in the Phase 2 VENTURE-Oral study was high and drove an efficient rate of enrollment," said Brian Lian, Ph.D., chief executive officer of Viking Therapeutics. "Despite its larger size, VENTURE-Oral was rapidly enrolled, highlighting the continued enthusiasm for new obesity therapeutics such as VK2735. We look forward to reporting data from this trial in the second half of 2025." Viking previously reported positive results from a 28-day Phase 1 multiple ascending dose (MAD) clinical trial of the tablet formulation of VK2735 in healthy volunteers with a BMI ≥30. Cohorts receiving VK2735 demonstrated dose-dependent reductions in mean body weight from baseline, ranging up to 8.2%. Persistent weight loss effects were observed at follow-up visits through Day 57, ranging up to 8.3% from baseline, four weeks after the last dose of VK2735 was administered. An exploratory assessment of the proportion of subjects achieving at least 5% weight loss after 28 days demonstrated that up to 100% of VK2735-treated subjects achieved ≥5% weight loss, compared with 0% for placebo. Based on a preliminary evaluation of weight loss trajectories at multiple dose levels, the company believes that continued treatment beyond 28 days may provide further reductions in body weight. In the MAD trial, oral VK2735 also demonstrated encouraging safety and tolerability through 28 days of once-daily dosing at doses up to and including 100 mg. The majority (99%) of observed treatment emergent adverse events were mild or moderate, with the majority (90%) reported as mild. Similarly, all observed gastrointestinal adverse events were reported as mild or moderate, with the majority (84%) reported as mild. Concurrent with the development of oral VK2735, Viking is also advancing a subcutaneous formulation of VK2735 through clinical development. The company previously announced positive data from the Phase 2 VENTURE study of subcutaneous VK2735, with the trial successfully achieving its primary and all secondary endpoints. Patients receiving VK2735 demonstrated statistically significant reductions in mean body weight from baseline, ranging up to 14.7%. Statistically significant differences compared to placebo were observed for all doses starting at Week 1 and were maintained throughout the course of the study. Weight loss in all treated cohorts appeared to be progressive through 13 weeks and did not show evidence of plateauing. VK2735 also demonstrated encouraging safety and tolerability in the VENTURE study, with the majority of observed adverse events being reported as mild or moderate. The company plans to initiate Phase 3 development with the subcutaneous formulation of VK2735 in the first half of 2025. About GLP-1 and Dual GLP-1/GIP Agonists Activation of the glucagon-like peptide 1 (GLP-1) receptor has been shown to decrease glucose, reduce appetite, lower body weight, and improve insulin sensitivity in patients with type 2 diabetes, obesity, or both. Semaglutide is a GLP-1 receptor agonist that has been approved by the U.S. Food and Drug Administration and is currently marketed in various dosage strengths and forms as Ozempic®, Rybelsus®, and Wegovy®. More recently, research efforts have explored the potential co-activation of the glucose-dependent insulinotropic peptide (GIP) receptor as a means of enhancing the therapeutic benefits of GLP-1 receptor activation. Tirzepatide is a dual GLP-1/GIP receptor agonist that has been approved by the U.S. Food and Drug Administration and is currently marketed in various dosage strengths and forms as Mounjaro® and Zepbound®. About Viking Therapeutics, Inc. Viking Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on the development of novel first-in-class or best-in-class therapies for the treatment of metabolic and endocrine disorders, with three compounds currently in clinical trials. Viking's research and development activities leverage its expertise in metabolism to develop innovative therapeutics designed to improve patients' lives. Viking's clinical programs include VK2735, a novel dual agonist of the glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptors for the potential treatment of various metabolic disorders. Data from a Phase 1 and a Phase 2 trial evaluating VK2735 (dosed subcutaneously) for metabolic disorders demonstrated an encouraging safety and tolerability profile as well as positive signs of clinical benefit. Concurrently, the company is evaluating an oral formulation of VK2735 in a Phase 2 trial. Viking is also developing VK2809, a novel, orally available, small molecule selective thyroid hormone receptor beta agonist for the treatment of lipid and metabolic disorders. The compound successfully achieved both the primary and secondary endpoints in a recently completed Phase 2b study for the treatment of biopsy-confirmed non-alcoholic steatohepatitis (NASH) and fibrosis. In a Phase 2a trial for the treatment of non-alcoholic fatty liver disease (NAFLD) and elevated LDL-C, patients who received VK2809 demonstrated statistically significant reductions in LDL-C and liver fat content compared with patients who received placebo. The company's newest program is evaluating a series of internally developed dual amylin and calcitonin receptor agonists (or DACRAs) for the treatment of obesity and other metabolic disorders. In the rare disease space, Viking is developing VK0214, a novel, orally available, small molecule selective thyroid hormone receptor beta agonist for the potential treatment of X-linked adrenoleukodystrophy (X-ALD). In a Phase 1b clinical trial in patients with the adrenomyeloneuropathy (AMN) form of X-ALD, VK0214 was shown to be safe and well-tolerated, while driving significant reductions in plasma levels of very long-chain fatty acids (VLCFAs) and other lipids, as compared to placebo. For more information about Viking Therapeutics, please visit . Forward-Looking Statements This press release contains forward-looking statements regarding Viking Therapeutics, Inc., under the safe harbor provisions of the U.S. Private Securities Litigation Reform Act of 1995, including statements about Viking's expectations regarding its clinical and preclinical development programs, anticipated timing for reporting clinical data and cash resources. Forward-looking statements are subject to risks and uncertainties that could cause actual results to differ materially and adversely and reported results should not be considered as an indication of future performance. These risks and uncertainties include, but are not limited to: risks associated with the success, cost and timing of Viking's product candidate development activities and clinical trials, including those for VK2735, VK0214, VK2809, and the company's other incretin receptor agonists; risks that prior clinical and preclinical results may not be replicated; risks regarding regulatory requirements; and other risks that are described in Viking's most recent periodic reports filed with the Securities and Exchange Commission, including Viking's Annual Report on Form 10-K for the year ended December 31, 2023, and subsequent Quarterly Reports on Form 10-Q, including the risk factors set forth in those filings. These forward-looking statements speak only as of the date hereof. Viking disclaims any obligation to update these forward-looking statements except as required by law. SOURCE Viking Therapeutics, Inc. 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