别名 Activation B7-1 antigen、B-lymphocyte activation antigen B7、B7 + [13] |
简介 Costimulatory molecule that belongs to the immunoglobulin superfamily that plays an important role in T-lymphocyte activation (PubMed:38467718). Acts as the primary auxiliary signal augmenting the MHC/TCR signal in naive T-cells together with the CD28 receptor which is constitutively expressed on the cell surface of T-cells (PubMed:12196291). In turn, activates different signaling pathways such as NF-kappa-B or MAPK leading to the production of different cytokines (PubMed:10438913). In addition, CD28/CD80 costimulatory signal stimulates glucose metabolism and ATP synthesis of T-cells by activating the PI3K/Akt signaling pathway (PubMed:12121659). Acts also as a regulator of PDL1/PDCD1 interactions to limit excess engagement of PDL1 and its inhibitory role in immune responses (PubMed:36727298). Expressed on B-cells, plays a critical role in regulating interactions between B-cells and T-cells in both early and late germinal center responses, which are crucial for the generation of effective humoral immune responses (By similarity).
(Microbial infection) Acts as a receptor for adenovirus subgroup B. |
作用机制 CD80抑制剂 [+1] |
最高研发阶段批准上市 |
首次获批国家/地区 美国 |
首次获批日期2011-06-15 |
作用机制 CD80调节剂 [+1] |
最高研发阶段批准上市 |
首次获批国家/地区 美国 |
首次获批日期2005-12-23 |
作用机制 CD58 modulators [+4] |
在研适应症 |
最高研发阶段临床3期 |
首次获批国家/地区- |
首次获批日期1800-01-20 |
开始日期2025-12-01 |
开始日期2025-09-01 |
申办/合作机构 [+1] |
开始日期2025-08-01 |
申办/合作机构 [+1] |