别名 DISEASE PARKINSON'S、Disease Parkinson's、Disease;Parkinsons + [77] |
简介 A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75) |
作用机制 GABAA receptor正向变构调节剂 |
在研机构 |
最高研发阶段批准上市 |
首次获批国家/地区 美国 |
首次获批日期2023-08-04 |
靶点 |
作用机制 CSF-3R激动剂 |
在研机构 |
原研机构 |
在研适应症 |
最高研发阶段批准上市 |
首次获批国家/地区 中国 |
首次获批日期2023-05-06 |
靶点 |
作用机制 PPAR激动剂 |
在研机构 |
原研机构 |
非在研适应症 |
最高研发阶段批准上市 |
首次获批国家/地区 中国 |
首次获批日期2021-10-22 |
开始日期3010-03-12 |
申办/合作机构 |
开始日期2025-12-01 |
开始日期2025-04-01 |
申办/合作机构 |