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更新于：2025-07-22
Lipoic acid
硫辛酸
更新于：2025-07-22
概要
基本信息
原研机构- |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 德国 (1966-01-01), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C8H14O2S2 |
InChIKeyAGBQKNBQESQNJD-SSDOTTSWSA-N |
CAS号1200-22-2 |
关联
211
项与 硫辛酸 相关的临床试验NCT05713799
Phase II Trial of the Combination of Alpha-lipoic Acid and Mirabegron in Women and in Men With Obesity
NCT05371288
The Role of Glutathione Deficiency and MSIDS Variables in Long COVID-19
RBR-4qqbzzz
Clinical study of Alpha-Lipoic Acid as an adjuvant drug for the treatment of Depression
100 项与 硫辛酸 相关的临床结果
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100 项与 硫辛酸 相关的转化医学
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100 项与 硫辛酸 相关的专利（医药）
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9,140
项与 硫辛酸 相关的文献（医药）2025-12-01Current Urology Reports
Management Strategies for Patients with Non-Infectious Cystitis: A Review of the Literature
Review
作者: Sawyer, Kathryn ; Zheng, Yu ; Gupta, Priyanka ; Aqeel, Jawad
PURPOSE OF REVIEW:
The management of noninfectious cystitis continues to evolve as new treatments continue to be developed and investigated. This review aims to synthesize the most recent data regarding management strategies for noninfectious cystitis focused on non-ulcerative, ulcerative, eosinophilic, and ketamine-induced cystitis.
RECENT FINDINGS:
Several novel treatments have shown promise as management options including combination antihistamine therapy, phosphodiesterase 5 inhibitors, alpha lipoic acid supplements, and onabotulinumtoxin A. Recent studies have also found pentosan polysulfate sodium to have adverse ophthalmologic effects. For patients with ulcerative cystitis, recent research has shown that fulguration with or without triamcinolone injections should not be delayed. The treatment of noninfectious cystitis should be patient specific based on factors including etiology and symptom profile. Multimodal regimens are often the most effective. Treatment should be started with conservative options and escalated as necessary to oral treatments, intravesical options, or procedural management.
2025-12-01MOLECULAR BIOLOGY REPORTS
Bioprospecting of 101 facultative rumen bacterial isolates through comprehensive genome analysis
Article
作者: Kachhawaha, Subhash ; Bhure, Minal ; Kumawat, Ram N ; Patil, Niteen V ; Joshi, Chaitanya G ; Savaliya, Kaksha ; Nehra, Chitra ; Joshi, Madhvi ; Patil, Sonal ; Shah, Tejas ; Pandit, Ramesh ; Patel, Ashutosh K
BACKGROUND:
Microbes within the rumen play a pivotal role in the digestion of feed ingested by the ruminants. Researchers have been investigating microbes within rumen to assess its genetic capabilities, which hold immense potential across various fields including agro-industrial advantages. Since rumen is preliminary an anaerobic sac, numerous anaerobic bacteria and fungi have been isolated and characterized, however facultative anaerobic bacteria yet not fully investigated.
METHODS AND RESULTS:
In present study, we isolated, characterized and performed whole genome analysis of 101 facultative anaerobic bacteria from rumen, offering a unique perspective compared to metagenomic approaches. All assembled genomes were of high quality, i.e. completeness 100% (only seven were between 92 and 99.5%) and only two had contamination > 5%. We identified 9,542 sequences of Carbohydrate-Active Enzymes (CAZymes). Over 8,136 of these CAZymes were full-length sequences, with 2,048 harbouring signal peptides also. Xylan (n = 634), pectin (n = 604), and starch (n = 312) degrading enzyme sequences were dominant. Several isolates also harbour secondary metabolite biosynthesis gene clusters for various metabolites, including fengycin, lichenysin, bacillibactins, bacilysin etc. All the isolates have metabolic versatility, encompassing pathways such as carbohydrate, amino acid, lipid, and vitamin and cofactor metabolism. Intriguingly, lipoic acid metabolism was absent in most of these facultative bacterial isolates.
CONCLUSION:
This comprehensive study sheds light on the genetic potential of culturable facultative rumen bacteria, emphasizing their pivotal roles in carbohydrate degradation, secondary metabolite production, and metabolic diversity. These findings hold promise for enhancing ruminant nutrition, advancing eco-friendly biomass conversion, and bolstering bioprospecting of industrially important biocules and enzymes biofuel production.
2025-10-01MATERIALS LETTERS
Synthesis of double-network poly(ionic liquid) and its application as a removable, reusable, and tough adhesive to repair ancient pottery
作者: Li, Li ; Zhu, Jianfeng ; Xie, Chang ; Wang, Zhuo ; Wang, Lei ; Liu, Yi
A novel double-network poly(ionic liquid) (DN-PIL) adhesive for repairing ancient pottery has been prepared via solvent evaporation-induced polymerization of lipoic acid (LA) counter ion in polyimidazolium-based IL.The DN-PILs displayed tough adhesive, removable and reusable abilities, because of the intra-/intermol. non-covalent interactions (such as hydrogen bonding, electrostatic interaction and cation-π interactions) derived from the double-network dynamic and reversible reaction of disulfide bonds in LA counterion.Thus, our work would provide a new candidate to substitute the epoxy resins for practical application.
100 项与 硫辛酸 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 糖尿病性神经病变 | 德国 | - | 1966-01-01 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 糖尿病 | 临床3期 | 中国 | 2010-11-01 | |
| 寻常痤疮 | 临床2期 | 中国 | 2019-07-11 | |
| 糖尿病周围神经病变 | 临床1期 | 中国 | 2021-07-08 | |
| 铁过剩 | 临床前 | - | - | 2025-05-16 |
| 2型糖尿病 | 临床前 | 卡塔尔 | 2019-09-17 | |
| 胰岛素抵抗 | 临床前 | 卡塔尔 | 2019-09-17 |
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临床结果
临床结果
适应症
分期
评价
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N/A | 15 | ALA (AlphaLipoidAcid Group) | 築鑰製遞範蓋顧鏇簾膚(夢廠淵獵顧膚鬱壓範膚) = 壓艱襯蓋觸醖構簾繭襯 獵遞構蓋壓繭獵衊糧淵 (構壓艱願積鑰淵鬱選繭, 39.93) 更多 | - | 2025-03-27 | ||
ALA (Alpha Lipoic Acid) | 夢獵構憲積鹽糧構觸窪(鹹齋淵範鑰淵築獵範壓) = 遞淵選鑰顧廠構醖鏇觸 鏇衊鬱鹽糧廠鏇襯艱壓 (遞餘網夢糧糧鹽繭鏇鹹, 積範積糧觸憲蓋製觸鹹 ~ 蓋積製積鑰簾築鏇蓋窪) 更多 | ||||||
N/A | 118 | 糧選觸遞窪積窪選鬱糧(積憲艱壓衊顧鬱繭襯憲) = 範窪蓋構醖選築遞選淵 顧繭壓範觸憲製選憲觸 (壓選鏇鏇衊餘蓋簾壓廠 ) | 积极 | 2025-03-14 | |||
糧選觸遞窪積窪選鬱糧(積憲艱壓衊顧鬱繭襯憲) = 繭網鬱選積壓蓋繭夢餘 顧繭壓範觸憲製選憲觸 (壓選鏇鏇衊餘蓋簾壓廠 ) | |||||||
临床2期 | 115 | (Arm 1: Lipoic Acid) | 糧範鬱夢遞齋鏇網積鬱(憲願廠鬱遞鬱襯鑰遞遞) = 鏇憲蓋製糧鏇襯窪鹽觸 範衊淵選願鑰鬱簾觸窪 (齋鹹觸簾選壓繭鑰範齋, 衊鹽廠顧齋壓繭築憲壓 ~ 獵淵衊構蓋膚憲艱遞選) | - | 2025-03-03 | ||
Placebo (Arm 2: Placebo) | 糧範鬱夢遞齋鏇網積鬱(憲願廠鬱遞鬱襯鑰遞遞) = 醖願醖廠網獵繭鹹憲積 範衊淵選願鑰鬱簾觸窪 (齋鹹觸簾選壓繭鑰範齋, 積觸觸醖糧網製築襯艱 ~ 積鬱網齋襯鹽夢網觸願) | ||||||
N/A | - | ALA-SM (LUDLEV® 300 mg/46.2 mg) | 鑰網蓋願積窪簾襯鬱膚(襯繭鹽鹽夢艱醖餘範積) = noteworthy trend towards reduction 鏇願網餘獵糧夢餘積窪 (觸簾網憲鹽餘築夢糧廠 ) 更多 | - | 2024-05-19 | ||
Placebo | |||||||
N/A | - | ALA-SM (LUDLEV® 300 mg/46.2 mg) | 齋製鬱製襯衊憲選醖築(築壓襯壓窪願壓夢襯窪) = reported by 8% of group A and 4% of group B, but no participants were discontinued 獵鑰餘襯憲製顧獵鑰餘 (餘壓糧築鏇膚餘築膚觸 ) 更多 | - | 2024-05-19 | ||
Placebo | |||||||
N/A | - | ALA-SM (LUDLEV® 300 mg/46.2 mg) | 膚齋願鏇願憲醖範淵艱(廠構齋顧鹹醖壓糧製鑰) = noteworthy trend towards reduction 壓糧襯構網醖廠鏇蓋繭 (醖糧積醖願窪遞獵鹽網 ) 更多 | - | 2024-05-19 | ||
Placebo | |||||||
N/A | - | ALA-SM (LUDLEV® 300 mg/46.2 mg) | 鏇鏇淵艱餘淵醖膚積廠(顧網艱簾願夢鏇齋積繭) = reported by 8% of group A and 4% of group B, but no participants were discontinued 窪蓋構網壓積選鏇簾獵 (衊窪鑰餘憲鹹鏇艱繭構 ) 更多 | - | 2024-05-19 | ||
Placebo | |||||||
临床3期 | 习惯性流产 sperm DNA damage | oxidative stress | 37 | Alpha-Lipoic Acid (ALA) 600 mg/day | 鏇選積壓鏇願壓壓餘積(鬱繭淵衊顧窪積獵艱網) = 觸鹽膚衊憲願獵壓範觸 壓鹽觸願艱鬱顧廠鹽顧 (齋網簾選壓製觸鹽衊範 ) | 积极 | 2023-01-01 | |
Placebo | 鏇選積壓鏇願壓壓餘積(鬱繭淵衊顧窪積獵艱網) = 餘膚範蓋壓膚齋襯鏇繭 壓鹽觸願艱鬱顧廠鹽顧 (齋網簾選壓製觸鹽衊範 ) | ||||||
N/A | 100 | Alpha-lipoic acid (ALA) supplementation | 簾顧廠艱簾夢齋構廠壓(膚範醖選構簾膚醖鏇鹹) = 襯餘選鹽衊廠簾築築鏇 壓積膚顧積襯廠夢醖範 (遞蓋簾觸遞壓網餘網觸 ) | 不佳 | 2022-10-20 | ||
Placebo | 簾顧廠艱簾夢齋構廠壓(膚範醖選構簾膚醖鏇鹹) = 構鬱壓網鏇膚齋壓膚願 壓積膚顧積襯廠夢醖範 (遞蓋簾觸遞壓網餘網觸 ) | ||||||
临床2期 | 37 | (Alpha-lipoic Acid and Acetyl-L-carnitine) | 膚顧鹽夢衊積鏇餘築壓(齋積齋築糧網蓋鏇衊窪) = 衊餘鬱糧網襯鏇膚構壓 遞獵壓顧窪糧遞選獵選 (窪齋構顧積構鹽廠範窪, 20.9) 更多 | - | 2021-08-03 | ||
Control (Placebo) | 膚顧鹽夢衊積鏇餘築壓(齋積齋築糧網蓋鏇衊窪) = 製構顧蓋網蓋網夢夢淵 遞獵壓顧窪糧遞選獵選 (窪齋構顧積構鹽廠範窪, 10.3) 更多 |
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