The goal of this clinical trial is to learn if caffeine citrate prevents apneic events that result in sick visits in moderately preterm infants after discharge from the hospital. It will also learn if the use of caffeine leads to better developmental outcomes at 12 months of age.
Our research questions are:
1. Does continued treatment of moderately preterm newborns with caffeine citrate after hospital discharge prevent or decrease apneic events that result in sick visits?
2. Will the continued use of caffeine citrate lead to improved developmental outcomes among infants at 12 months of age?
Researchers will compare caffeine citrate to a placebo (a look-alike substance that contains no drug) to see if caffeine citrate prevents apneic spells which result in healthcare visits.
Parents of participants will:
1. Administer caffeine citrate 20mg/kg/day or a placebo (equivalent volume of sterile water) orally every day for up to 28 days after hospital discharge
2. Keep a diary of symptoms and any apneic events
3. Check in with researchers via telephone call once a week
4. Return to clinic for infant physical examination at 28 days
5. Return to the clinic for infant physical examination at 2 months
5. Return to clinic for infant neurodevelopmental examination with Ages and Stages Questionnaire at 12 months of age

开始日期2026-04-01

申办/合作机构

The University of Alabama at Birmingham

[+1]

NCT06972108

/ Not yet recruiting临床2期IIT

Caffeine for Oxygen Dependent Meconium Aspiration Syndrome

When babies are stressed in the womb, they sometimes pass meconium in the amniotic fluid. When this happens, they may swallow the meconium-stained fluid into their lungs which may cause them to have poor oxygen levels and require resuscitation and significant breathing support in the early hours after birth. This is referred to as Meconium Aspiration Syndrome (MAS). Some babies may recover slowly and require breathing and/or oxygen support for days. Caffeine is a drug that can help improve breathing efforts and is commonly used in premature babies who do not have regular or strong breathing efforts. Caffeine has been used in babies with MAS who recovered slowly (i.e. requiring breathing or oxygen support for a longer period) for several years now. Despite having success in many babies, there is no evidence to examine its effectiveness and mechanism of action. This pilot study proposes to look at the effects of caffeine in babies with MAS who require ongoing breathing and oxygen support. There will also be examination of whether caffeine improves breathing efforts with better lung opening using ultrasound images of the lungs.

开始日期2026-04-01

申办/合作机构

University of Alberta

NCT07262060

/ Not yet recruiting临床2期IIT

Optimizing Caffeine Therapy for Hypoxia in Preterm Neonates: A Randomized Trial Assessing Efficacy, Acute Kidney and Brain Injury, Safety, and Pharmacokinetics

This study is being done to see if additional caffeine citrate (20 milligrams per kilogram IV bolus) helps babies with low kidney oxygenation already being treated with caffeine citrate (20 milligrams per kilogram IV bolus on day of life (DOL) 1 followed by 8 milligrams per kilogram daily maintenance). The investigators hypothesize that additional caffeine will improve kidney oxygen levels, while not causing any brain injury, and may reduce rates of acute kidney injury compared to placebo. This study will take place in preterm babies born less than 30 weeks gestational age, with the intervention occurring between greater than 48 hours of age until DOL 14 and outcomes tracked until neonatal intensive care unit (NICU) discharge.

开始日期2026-03-01

申办/合作机构

University of Wisconsin-Madison

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100 项与枸橼酸咖啡因相关的专利（医药）

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27,930

项与枸橼酸咖啡因相关的文献（医药）

2026-03-16·SPECTROSCOPY LETTERS

Ecological and human health risk assessment of pharmaceutical compounds in the Indian river ecosystem

作者: Ruby, Ruby ; Giri, Arup ; Dimple, Dimple ; Jyoti, Jyoti

Pharmaceutical compounds release into aquatic ecosystem has become a critical problem because they can harm aquatic organisms and humans. Humans may have serious effects due to presence of phamaceuticals in drinking water.This study aims to analyze pharmaceutical compound ecol. and human health risk assessments in thirteen Indian River ecosystems. In this study, various pharmaceuticals, such as ciprofloxacin, norfloxacin, aspirin, carbamazepine, caffeine, and ibuprofen, were detected in different river ecosystems across India. This study aims to analyze the concentrations of pharmaceutical compounds, including the risk quotient (RQ), while performing an ecol. risk assessment.For human health risk assessment, metrics such as acceptable daily intake (ADI) and the risk quotient were employed to assess human health (RQH). The health risk models revealed that the Sirsa River posed significant ecol. threats because RQ greater than 1, whereas the other rivers presented moderate risks. Children were found to be more vulnerable to pharmaceutical intake, and all the rivers presented RQH values exceeding 1 for adults, underscoring serious health concerns.This study will help categorize pharmaceutical compounds and analyze the ecol. and human health risks to water systems. This study provides key insights for policymakers and public health efforts to address pharmaceutical pollution in Indian rivers. It also aligns with the UN Sustainable Development Goals, particularly SDGs 6 and 12.

2026-03-01·Journal of neonatal-perinatal medicine

Recurrence of apnea of prematurity following early discontinuation of caffeine: A prospective analytical study

Article

作者: Rahul, Aswathy ; Kumar, Nikhil ; Nandakumar, Anand ; Amma, Sobhakumar Saraswathy ; Sujatha, Radhika

Background:

There are variations in practices regarding the initiation and stopping of caffeine for apnea of prematurity among neonates above 28 weeks.

Objective:

To estimate the proportion of recurrence of apnea of prematurity among neonates between 28 and 32 weeks on stopping caffeine after an apnea-free period of 7 days.

Methodology:

This was a prospective, observational study conducted in a tertiary care government medical college from April 2023 to May 2024. Study population were neonates between 28 and 32 weeks gestation. Injection Caffeine citrate was started for all within 2 hours of birth and it was stopped after an apnea-free period of 7 days.

Results:

Out of the total 300 neonates enrolled, 285 were available for primary outcome analysis. Out of the 38.2% ( n = 109) who developed recurrence of apnea, only 11.9% (CI: 8.4%–16.3%, n = 34) was due to apnea of prematurity. Late-onset sepsis was the major cause in the rest. The median day of recurrence was 7 days (IQR 3) after stopping caffeine. On multivariable logistic regression birth weight less than 1250 g was the only significant predictor for the recurrence.

Conclusion:

The incidence of recurrence of apnea of prematurity was only 11.9 % (CI 8.4%–16.3%) among 28–32 weeks babies on early stopping of caffeine. For judicious use of caffeine, considering its cost and side effects, it may be reasonable to stop it after an apnea-free period of 7 days. Close monitoring is required for 7–10 days in babies less than 1250 g.

2026-02-01·NEUROPHARMACOLOGY

Caffeine Citrate does not reduce brain injury following inflammation-amplified hypoxia ischaemia or hypoxia ischaemia in the Newborn Piglet Model

Article

作者: Bainbridge, Alan ; Norris, Georgina ; Campbell, Ellie ; Robertson, Nicola J ; Tucker, Katie ; Pang, Raymand ; Torrealdea, Francisco ; Barks, John ; Tsuda, Kennosuke ; Mintoft, Alison ; Meehan, Christopher ; Kim, Yujin ; Han, Louise ; d'Angelo, Ilenia ; Maple, George

There is a need to develop alternative therapies for neonatal encephalopathy (NE) in term babies. Caffeine citrate exposure saw benefit in preclinical models of hypoxia-ischaemia (HI). We assessed the safety and cytoprotective efficacy of caffeine citrate in an inflammation-amplified (IA-HI) and HI newborn piglet model based on the probability of treatment superiority (Pr_(sup)) of magnetic resonance spectroscopy, amplitude integrated encephalography (aEEG/EEG) and immunohistochemistry outcomes. Eighteen newborn piglets were randomised to saline, 20/10/10 mg/kg or 60/30/30 mg/kg caffeine citrate following IA-HI. A further twenty piglets were randomised to saline or 40/10/10 mg/kg caffeine citrate following HI. Caffeine plasma concentrations were within range following a 20/10/10 mg/kg dosage but were lower than putative target levels following a 40/10/10 mg/kg dosage. Caffeine concentrations exceeded toxic levels following a 60/30/30 mg/kg dosage. Following IA-HI, 20/10/10 or 60/30/30 mg/kg caffeine citrate treatment failed to reduce white matter (WM) (Pr_(sup) 39.3 %, 52.5 %) and basal ganglia and thalamic (BGT) (Pr_(sup) 35.0 %, 50.3 %) lactate/N-acetylaspartate (Lac/NAA), preserve the phosphocreatine/exchange phosphate pool (PCr/Epp) ratio (Pr_(sup) 44.2 %, 62.0 %), or improve aEEG/EEG recovery (Pr_(sup) 22.4 %, 21.7 %). A 60/30/30 mg/kg dose demonstrated increased cell death, indicating toxicity. Following HI, 40/10/10 mg/kg caffeine citrate treatment failed to reduce WM (Pr_(sup) 58.3 %) and BGT (Pr_(sup) 48.0 %) Lac/NAA, preserve the PCr/Epp ratio (Pr_(sup) 72.8 %), or improve aEEG/EEG recovery (Pr_(sup) 48.0 %), with seizures more refractory. However, there was a modest benefit in male caffeine-treated piglets following HI. The lack of neuroprotection observed following caffeine citrate treatment after both IA-HI and HI suggests further preclinical studies are required before clinical translation for term babies with NE.

204

项与枸橼酸咖啡因相关的新闻（医药）

2026-02-21

·Read-along-with-me

为什么有些人只需四小时睡眠就能蓬勃发展

NEWYORKER | annals of inquiry 2026-02-18 2957词难度等级-高 Why Some People Thrive on Four Hours of Sleep 为什么有些人只需四小时睡眠就能蓬勃发展 In February, a pop-up science column, Annals of Inquiry, is appearing in place of Kyle Chayka’s column, Infinite Scroll. Chayka will return in March. 2月，一档临时科普专栏《探究纪事》将取代凯尔·柴卡的《无尽滚动》专栏与读者见面。柴卡将于3月回归。 When Joanne Osmond was growing up, in rural Pennsylvania, her family had two nighttime rules: you had to stay in your room, and you had to be quiet. There was no rule that you had to be asleep—which was fortunate, because Osmond, her three brothers, and her two sisters rarely were. Osmond stayed up late reading novels from her school library. Her sisters loved solving crossword puzzles. Even her father, an engineer, tinkered with television sets late at night and early in the morning. Only Osmond’s mother, for whom the rules had been created, routinely got what she considered a full night’s sleep. 乔安妮·奥斯蒙德在宾夕法尼亚州乡村长大时，家里有两条夜间规矩：必须待在自己房间里，且必须保持安静。但并没有规定必须睡着——这很幸运，因为奥斯蒙德、她的三个兄弟和两个姐妹很少能睡着。奥斯蒙德经常熬夜阅读学校图书馆借来的小说。她的姐妹们喜欢玩填字游戏。就连她当工程师的父亲，也常在深夜和凌晨捣鼓电视机。只有奥斯蒙德的母亲能按常规睡上她认为的整宿觉，而这些规矩正是为她制定的。 Osmond, her siblings, and her father were what scientists call natural short sleepers. Some people don’t sleep enough because they have insomnia, or work a night shift; they tend to struggle with exhaustion, cognitive impairment, and even long-term health issues, such as elevated rates of depression and a higher risk of heart attack. But short sleepers, who make up less than one per cent of the population, spend significantly less time snoozing without any apparent health consequences. “Growing up, we didn’t realize that there was anything different about us,” Osmond told me. Only in 2011 did she learn that she has a genetic variation linked to short sleep. Her sisters, who were tested in 2019, have variations in the same gene. Osmond, now seventy-seven, sleeps no more than four hours a night. 奥斯蒙德、她的兄弟姐妹以及她的父亲，都是科学家所说的天生短睡眠者。有些人睡眠不足，是因为患有失眠症或上夜班。他们往往会饱受疲惫、认知障碍之苦，甚至会面临长期健康问题，比如抑郁症发病率升高和心脏病发作风险增加。但短睡眠者在人群中占比不到1%，他们睡眠时间明显更短，却没有明显的健康问题。奥斯蒙德告诉我：“从小到大，我们都没意识到自己有什么不同。”直到2011年，她才得知自己有一种与短睡眠相关的基因变异。她的姐妹们在2019年接受了检测，结果显示她们也有同一基因的变异。如今77岁的奥斯蒙德，每晚睡眠时间不超过4小时。 My curiosity about short sleepers was piqued after several of my friends (not for the first time) made New Year’s resolutions to sleep better. Sleep was also on my mind. I have never had insomnia, but in my late teens and twenties I bartended while going to school, and sleep felt like a luxury that I could opt out of if needed. When I became a journalist, a cup of strong black tea helped me start writing at four-thirty or 5 A.M.—my most productive time—before spending a full day at the office. As I enter my mid-thirties, however, I often start writing after sunrise, and caffeine has lost its power to reinvigorate me. When I’m sleep-deprived, my mind feels like hard leather: unpliant, easily creased under stress.journey-inline-newsletterinline-newsletter 我的几位朋友（这已不是第一次）立下新年决心，要改善睡眠质量，这激起了我对短睡眠者的好奇心。我也开始思考睡眠问题。我从未失眠过，但在十八九岁到二十多岁时，我边上学边在酒吧当调酒师，那时我觉得睡眠是一种奢侈品，必要时可以舍弃。成为记者后，清晨四点半或五点是我效率最高的时候，我会喝上一杯浓烈的红茶，然后开始写作，之后再去办公室工作一整天。然而，到了三十五六岁，我常常要等太阳升起后才开始写作，而且咖啡因也无法再让我恢复精力了。睡眠不足时，我的大脑就像坚硬的皮革，缺乏弹性，一有压力就容易出现褶皱。 If you’ve ever wondered what you could do with a few more hours in the day, Osmond suggests an answer. A rough calculation suggests that she has been conscious for thirteen years longer than her average peer from elementary school. She has certainly made use of the time: she went to college for engineering, married an engineer, had five children, in the suburbs of Chicago, and worked demanding jobs in technology and management. While her husband was asleep, she studied educational policy, eventually becoming president of the Illinois Association of School Boards. During one of our conversations, she told me that, after I went to bed, she’d be teaching students from around the globe how to start their own businesses. “The world seems to need eight hours, and I don’t,” she told me. I felt a warm stirring of envy in my gut. 如果你曾好奇一天多几个小时能干些什么，奥斯蒙德给出了答案。粗略计算表明，她清醒的时间比她小学时的同龄人平均多出了13年。她显然充分利用了这些时间：她上大学学的是工程专业，嫁给了一位工程师，在芝加哥郊区养育了五个孩子，还从事过颇具挑战性的技术和管理工作。在丈夫睡觉的时候，她研究教育政策，最终成为了伊利诺伊州学校董事会协会的主席。在我们的一次交谈中，她告诉我，等我睡了以后，她要教全球各地的学生如何创业。她对我说：“似乎大家都需要睡八个小时，可我不用。”我心里涌起一股热乎的羡慕劲儿。 Ying-Hui Fu, a human geneticist at U.C.S.F. who has studied about a hundred short sleepers, told me that they raise fascinating questions about the nature of sleep. She is sometimes asked why short sleepers are so rare: wouldn’t evolution reward individuals who spend less of their lives unconscious? But she speculates that such a trait only became prized in modern times. “Before electricity, there was no advantage to being a short sleeper in darkness,” she said. Fu’s work also suggests a connection between our sleep needs and the ways we fill our days. Many of the people she’s studied are drawn to demanding jobs and intensive hobbies. They often have a high tolerance for pain. Many don’t need to drink tea or coffee, and they don’t get jet lag. “I call them Homo sapiens 2.0,” Fu joked. Perhaps the deepest mystery is how short sleepers thrive on so little rest—and whether anyone else might ever be able to do the same. 傅英惠是加州大学旧金山分校的人类遗传学家。她研究了约一百位短睡眠者，她告诉我，这些人对睡眠的本质提出了引人深思的问题。有时有人会问她，为什么短睡眠者如此罕见：进化难道不会青睐那些花更少时间处于无意识状态的人吗？但她推测，这种特质直到现代才受到重视。她说：“在有电之前，在黑暗中成为短睡眠者并没有优势。”傅英惠的研究还表明，我们的睡眠需求与我们度过每一天的方式之间存在联系。她研究的许多人都热衷于高要求的工作和高强度的爱好。他们通常对疼痛有较高的耐受性。很多人不需要喝茶或咖啡，而且不会有时差反应。傅英惠开玩笑说：“我称他们为‘智人2.0’。”或许最深刻的谜团在于，短睡眠者如何能在如此少的休息下茁壮成长，以及其他人是否也能做到这一点。 Most animals need sleep, but it’s difficult to say exactly why. One leading theory is that sleep replenishes energy that’s stored in brain cells. Another postulates that sleep removes waste from the brain. Still another says that sleep allows us to consolidate memories from the preceding day. If sleep’s purpose is elusive, so is the number of hours the job requires. Bats sleep eighteen to twenty hours a day, while wild elephants sleep just two hours a night. In humans, eight hours is dogma—“My body needs eight,” Fu told me—but our actual sleep requirements depend in large part on genetics. 大多数动物都需要睡眠，但确切原因却难以说清。一种主流理论认为，睡眠能补充脑细胞中储存的能量。另一种假设认为，睡眠能清除大脑中的废物。还有一种说法是，睡眠能帮助我们巩固前一天的记忆。如果说睡眠的目的难以捉摸，那么所需的时长同样如此。蝙蝠每天要睡18到20个小时，而野生大象每晚仅睡2个小时。对人类而言，8小时睡眠是一种既定观念——傅颖慧（Ying-Hui Fu）告诉我：“我的身体需要睡8个小时”——但我们实际的睡眠需求在很大程度上取决于基因。 What we know for certain is that terrible things happen when animals stop sleeping entirely. In 1894, a Russian doctor deprived some puppies of food and others of sleep. The sleep-deprived died within days, but the hungry survived. The Guinness Book of Records no longer accepts entries for the longest time a human can stay awake, citing “inherent dangers associated with sleep deprivation.” Most of us have the opposite ambition: we have become so fixated on sleep amount and quality that sleep books spend months on best-seller lists, and the market for trackers such as Oura and Whoop is valued in the billions of dollars. There is even a modern affliction called orthosomnia, described by one scientific article as “the obsessive pursuit of optimal sleep metrics.” Tragically, it may lead to poor sleep. 我们可以确定的是，当动物完全停止睡眠时，可怕的事情就会发生。1894年，一位俄国医生分别对一些幼犬进行了禁食和剥夺睡眠的实验。被剥夺睡眠的幼犬在几天内就死亡了，而挨饿的幼犬却存活了下来。《吉尼斯世界纪录大全》不再接受人类最长清醒时间的记录条目，理由是“睡眠剥夺存在内在危险”。而我们大多数人则有着相反的追求：我们过于关注睡眠的时长和质量，以至于有关睡眠的书籍能在畅销书排行榜上停留数月，像Oura和Whoop等睡眠追踪设备的市场价值高达数十亿美元。甚至有一种现代病症叫做“完美睡眠强迫症”，一篇科学文章将其描述为“对最佳睡眠指标的执着追求”。可悲的是，这可能会导致睡眠质量下降。 Sleep is orchestrated by two systems. The first is the so-called biological clock, which runs the body on a roughly twenty-four-hour cycle of sleeping and wakefulness. We all have slightly different circadian rhythms, which explains why some people (larks) get up early and others (night owls) stay up late. The second system is the homeostatic drive for sleep: the longer you are awake, the tireder you get. One’s circadian rhythm and one’s drive for sleep usually work in tandem, but they can fall out of step, Amita Sehgal, a chronobiologist and an investigator at the University of Pennsylvania’s Howard Hughes Medical Institute, told me. When you’re badly sleep-deprived, you want to go to bed no matter what time it is. (Our reactions to sleep deprivation seem to have a genetic basis, too: after thirty-eight hours awake, identical twins, who are born with identical DNA, performed more similarly on tests of reflexes and alertness than nonidentical twins did.) 睡眠受两个系统调控。第一个是所谓的生物钟，它会让身体大致按照24小时的周期进行睡眠和清醒的循环。我们每个人的昼夜节律都略有不同，这就解释了为什么有些人（早起的人）早起，而有些人（夜猫子）晚睡。第二个系统是睡眠的稳态驱动力：清醒的时间越长，人就越疲惫。宾夕法尼亚大学霍华德·休斯医学研究所的时间生物学家兼研究员阿米塔·塞加尔告诉我，人的昼夜节律和睡眠驱动力通常协同运作，但它们也可能失调。当你严重缺乏睡眠时，无论什么时候你都想上床睡觉。（我们对睡眠不足的反应似乎也有基因基础：在清醒38小时后，拥有相同DNA的同卵双胞胎在反射和警觉性测试中的表现，比异卵双胞胎更为相似。） People with extreme sleep patterns first became a focus of genetic research in the nineties, after a neurologist at the University of Utah, Chris Jones, met a woman who regularly went to sleep in the early evening and woke up in the middle of the night. Her granddaughter had the same sleep patterns, and Jones had a hunch that their habits might be explained by DNA. He got in touch with Louis Ptácek, a neurogeneticist at U.C.S.F., who helped him identify a DNA mutation that seemed to play a role. Fu joined Ptácek’s research team in 1997. “I was very good at finding mutations,” she told me. 上世纪九十年代，犹他大学的神经学家克里斯·琼斯遇到一位女士，她经常傍晚早早入睡，半夜就会醒来。此后，睡眠模式极端的人首次成为基因研究的焦点。她的孙女也有同样的睡眠模式，琼斯预感她们的睡眠习惯可能与基因有关。他联系了加州大学旧金山分校的神经遗传学家路易斯·普塔塞克，后者帮助他确定了一种似乎起作用的基因突变。1997 年，傅嫈惠加入了普塔塞克的研究团队。她告诉我：“我很擅长发现基因突变。” In response to the team’s findings—some of the first on how DNA influences sleep—thousands of people reached out. Many had irregular bedtimes and wake times but slept a consistent number of hours per night. An exceedingly small number, Fu said, went to bed very late and woke up very early. Curiously, they didn’t have the complaints that people with insomnia or other sleep disorders often do. In 2009, after studying a mother and a daughter who were both short sleepers, Fu published a paper about a variation in a gene called DEC2, which influences the production of orexin, a hormone associated with wakefulness. (Orexin deficiency is one of the main causes of narcolepsy.) When Fu bred mice with the same mutation, they slept less than other mice. 该团队的研究成果是最早一批关于DNA如何影响睡眠的研究，成果公布后，数千人主动联系了他们。许多人的就寝和起床时间不规律，但每晚的睡眠时间却固定不变。傅嫈惠表示，极少数人睡得很晚，却起得很早。奇怪的是，他们并没有像失眠患者或其他睡眠障碍患者那样抱怨连连。2009年，傅嫈惠研究了一对同为短睡眠者的母女，随后发表了一篇论文，探讨了一种名为DEC2的基因变异。该基因会影响食欲素的分泌，而食欲素是一种与清醒状态相关的激素。（食欲素缺乏是导致发作性睡病的主要原因之一。）傅嫈惠培育出带有相同变异基因的小鼠，结果发现这些小鼠的睡眠时间比其他小鼠短。 Since 2009, Fu and her colleagues have published research on six mutations across five genes linked to reduced sleep needs. (A few more genes are being researched, Fu told me.) Osmond and her sisters have variations on a gene that affects receptors for glutamate, an excitatory neurotransmitter with many functions throughout the brain. A different mutation was found in a father and a son in 2019; when Fu’s team introduced it into mice, the animals didn’t show memory deficits that usually appear in sleep-deprived mice. 自2009年以来，傅嫈惠（Fu）和她的同事发表了关于五个基因中的六种突变的研究，这些突变与减少睡眠需求有关。傅嫈惠告诉我，还有几个基因正在研究中。奥斯蒙德（Osmond）和她的姐妹们的一个基因存在变异，该基因会影响谷氨酸受体，谷氨酸是一种在整个大脑中具有多种功能的兴奋性神经递质。2019年，在一对父子身上发现了另一种突变；当傅嫈惠的团队将这种突变引入小鼠体内时，这些小鼠并未出现通常在睡眠不足的小鼠身上出现的记忆缺陷。 Sehgal, who has studied sleep in fruit flies, and who was not involved in Fu’s research, was intrigued by the fact that these genes do not seem to be connected by a particular sleep process or brain pathway. “It’s not one specific thing that stands out,” she said. Mehdi Tafti, a neurophysiologist and a geneticist, said that the unsolved mystery of short sleepers reveals our ignorance about how sleep works. When he looked for DEC2 mutations in hundreds of patients with irregular sleep patterns, he couldn’t find any. Fu believes that short sleepers have developed different ways of sleeping efficiently. Sehgal offered a different explanation: maybe their bodies don’t accumulate as much damage while awake. 塞加尔曾研究果蝇的睡眠情况，且未参与傅嫈惠的研究。她对这些基因似乎并未通过特定的睡眠过程或大脑通路相互关联这一事实很感兴趣。她说：“并没有一个特别突出的因素。”神经生理学家兼遗传学家迈赫迪·塔夫蒂表示，短睡眠者这一未解之谜揭示了我们对睡眠机制的认知不足。他在数百名睡眠模式异常的患者中寻找DEC2基因突变，但一无所获。傅嫈惠认为，短睡眠者已经形成了不同的高效睡眠方式。塞加尔提出了另一种解释：也许他们的身体在清醒时积累的损伤没那么多。 In theory, the genetic mutations associated with short sleep—and the pathways they seem to affect—could point to targets for drugs that would safely reduce our sleep needs. The discovery that orexin is linked to narcolepsy has sparked new pharmaceutical research, and last year an experimental orexin-blocking medication showed promise for insomnia in a clinical trial. Experimental drugs increasing orexin may also help people with narcolepsy stay awake longer. But it will be more challenging to develop a drug that transforms us into Osmonds. Fu said that, by finding short sleepers and then backtracking to single mutations, she may be missing out on other, more subtle genetic factors. When scientists scoured samples from nearly two hundred thousand people, in the U.K. Biobank, those mutations alone weren’t associated with extreme sleep patterns. And sleep is so important that Fu would want drug developers to proceed with caution. “The worst thing is, you come up with a drug and have horrible side effects,” she said. “You sleep less, but then, five years later, you get Alzheimer’s.” 理论上，与短睡眠相关的基因突变及其可能影响的路径，或许能为研发可安全减少睡眠需求的药物提供靶点。食欲素与嗜睡症相关这一发现，激发了新的药物研究。去年，一种实验性的食欲素阻断药物在临床试验中显示出对失眠症的治疗前景。实验性的食欲素增强药物，或许也能帮助嗜睡症患者保持更长时间的清醒。但研发一种能让我们变成像奥兹蒙德一家那样短睡眠者的药物，难度会更大。傅嫈惠表示，通过寻找短睡眠者，然后回溯单个基因突变，她可能忽略了其他更细微的遗传因素。科学家在英国生物样本库中对近二十万人的样本进行了详细研究，结果发现，仅这些基因突变与极端睡眠模式并无关联。睡眠至关重要，因此傅嫈惠希望药物研发人员谨慎行事。她说：“最糟糕的情况是，研发出的药物有严重的副作用。”“你睡眠减少了，但五年后却患上了阿尔茨海默病。” We fantasize about getting by with less sleep, Tafti said, because the twin goals of sleeping well and sleeping enough are more elusive than they sound. Good sleep hygiene—things like going to bed and waking up at the same time every day—requires us to set boundaries in our work and family responsibilities. It asks us to make choices that are prudent, but not very fun: leaving a party early, cutting back on alcohol, refraining from late-night snacks and screen time. Of course we’d rather take a pill than do all of that. Unfortunately, Tafti said, “we cannot dissolve the need for sleep.” At one time, clinicians hoped that central-nervous-system stimulants such as modafinil could help us sleep less without consequences, but they were wrong. (Like caffeine, wakefulness drugs suppress sleepiness; they don’t eliminate it.) Maybe the next best thing is to find out for yourself how long you need to sleep. One way to do that, according to the experts, is to go on vacation. Sleep only when you’re tired and get up when you feel rested, and you’ll naturally settle close to your actual needs. 塔夫蒂说，我们幻想能少睡点也没关系，因为睡好和睡足这两大目标比听起来要更难以实现。良好的睡眠习惯，比如每天在固定时间上床睡觉和起床，要求我们在工作和家庭责任方面设定界限。这要求我们做出明智但并不有趣的选择：提前离开派对、减少饮酒、避免吃夜宵和减少夜间使用电子设备的时间。当然，比起做这些，我们更愿意吃片药。不幸的是，塔夫蒂说：“我们无法消除对睡眠的需求。”曾几何时，临床医生希望莫达非尼等中枢神经系统兴奋剂能让我们少睡也无大碍，但他们错了。（和咖啡因一样，提神药物只能抑制困倦感，而不能消除它。）或许次优之选是亲自弄清楚自己需要多长时间的睡眠。专家表示，实现这一点的一个方法是去度假。累了就睡，休息好了就起床，这样你自然会接近自己实际的睡眠需求。 A few weeks ago, my alarm startled me awake at 2:46 A.M. I plodded to the kitchen, where I tried to make myself more alert by turning on some lamps. I’d organized a Zoom meeting with Osmond and two other short sleepers, at a time that they were typically awake but I wasn’t. Two of them had even joined the waiting room early. 几周前，凌晨2点46分，闹钟突然把我从睡梦中惊醒。我拖着沉重的步伐走进厨房，打开几盏灯，试图让自己清醒一些。我安排了一场Zoom会议，和奥斯蒙德以及另外两位睡眠少的人一起参加。这个时间通常是他们醒着而我还在睡觉的时候。其中两人甚至还提前进入了等候室。 Brad Johnson, a sixty-nine-year-old in Utah, had grown up in a family of five short sleepers and three normal sleepers. His mutation is associated with a neurotransmitter receptor found throughout the body, including in parts of the brain that are active during REM sleep and wakefulness. It was 1 A.M. where he was, and he was going to sleep soon. 犹他州69岁的布拉德·约翰逊成长于一个有五名短睡眠者和三名正常睡眠者的家庭。他携带的基因突变与一种遍布全身的神经递质受体有关，这种受体在快速眼动睡眠和清醒时活跃的部分大脑区域也有分布。他所在的地方已是凌晨1点，他很快就要去睡觉了。 Lynne White, an eighty-three-year-old in California, is the only short sleeper in her family. She has a mutation that, in lab mice, is associated with reduced non-REM sleep and more brain waves found in deep sleep. It was midnight where she was, and she was planning the rest of her evening. 住在加利福尼亚州的83岁老人琳恩·怀特是家中唯一的短睡眠者。她携带一种基因突变，在实验小鼠身上，这种突变与非快速眼动睡眠减少以及深度睡眠时更多脑电波的出现有关。她所在的地方已是午夜，她正在规划当晚接下来的活动。 The trio had never met, and they were curious about one another. Johnson asked how many hours the others usually slept. Osmond, in Chicago, was just waking up, having gone to sleep around 11 P.M. “I’ve been known to stay up, Brad, for three days,” White said, laughing. 这三个人从未见过面，他们对彼此都很好奇。约翰逊询问其他人通常睡几个小时。身处芝加哥的奥斯蒙德刚睡醒，他大约晚上11点就睡了。“布拉德，大家都知道我能连续三天不睡觉。”怀特笑着说。 Johnson used to sleep five hours, but lately he’s been needing about four and a half. He realized that he was a short sleeper at nineteen, during a two-year Mormon mission that had a bedtime of 10:30 P.M. “It was like asking me, ‘Why don’t you just be seven foot five by tomorrow?’ ” he told us. He recalled hiding in closets or bathrooms to read. 约翰逊过去通常睡五个小时，但最近他只需要大约四个半小时的睡眠。他在19岁时意识到自己是个睡眠少的人，当时他正在执行一项为期两年的摩门教传教任务，规定晚上10点30分就寝。他告诉我们：“这就好像在问我，‘你明天怎么不长到7英尺5英寸高呢？’”他回忆起自己曾躲在壁橱或浴室里看书。 “Our brains never stop,” Osmond said. “No matter what we try to do. It just needs to be filled.” 奥斯蒙德说：“我们的大脑永不停歇。”“无论我们做什么。”“它都得被填满。” “You just have to do things,” Johnson agreed. He used to worry that his sleep patterns were unhealthy—after all, he kept hearing that he was supposed to be sleeping much more. Learning about his genes has quieted those anxieties. These days, he’s a retired financial executive with eight children; he chairs a two-hundred-member choir and orchestra, volunteers for his church, and reads untold numbers of biographies. He’s also collecting all the talks and presentations that he’s given in the past fifty years. 约翰逊附和道：“你就得找点事做。”他过去常常担心自己的睡眠模式不健康，毕竟，他总是听说自己应该多睡点。了解了自己的基因后，他不再为此焦虑。如今，他是一位退休的金融高管，育有八个孩子。他担任着一个两百人合唱团和管弦乐队的负责人，在教会做义工，还读了无数本传记。他还在收集自己过去五十年来的所有演讲和报告资料。 Being awake so much can be an isolating experience. “There are times when I look outside and there isn’t a light on in any of the houses in my whole subdivision,” Osmond said. Whereas I might be frustrated by running out of time before bed, a short sleeper has to make sure she doesn’t run out of constructive tasks. (“I think one of my brothers died because he could not keep his mind busy and started to drink,” Osmond had told me previously.) Despite all of her volunteering, tutoring, working, parenting, and hobbying, she is always searching for new interests. In 2021, when Iceland’s volcanoes started to erupt for the first time in hundreds of years, she read everything she could find on geology. Then she got bored and moved on. 长时间清醒会让人产生孤立感。奥斯蒙德说：“有时候我望向窗外，整个小区的房子里都没有一盏灯亮着。”我可能会因睡前时间不够用而懊恼，而睡眠少的人则得确保自己有足够多有意义的事可做。（奥斯蒙德之前曾告诉我：“我觉得我的一个兄弟去世，是因为他没办法让自己的大脑有事可做，于是开始酗酒。”）尽管她做了大量志愿活动、辅导工作、日常工作，还要养育孩子、发展爱好，但她仍一直在寻找新的兴趣点。2021年，冰岛的火山数百年来首次喷发，她找来了所有能找到的地质学资料阅读。后来她厌倦了，便转移了兴趣。 Johnson’s children are not short sleepers, but he has seventeen grandchildren, and one of them might be. “I’ll get up at five, and she’ll be up shortly thereafter,” he said. He asked Osmond and White about their families. “I think I annoyed my children,” White said. “I was always waking them up.” When her son was in college, he got up early for a job and found her already awake, reading the newspaper. “You know, I’ve never seen you in bed,” he told her. 约翰逊的孩子都不是短睡眠者，但他有17个孙辈，其中可能有一个是。他说：“我5点起床，之后不久她也会起床。”他向奥斯蒙德和怀特询问了她们的家人情况。怀特说：“我觉得我惹孩子们烦了。”“我总是把他们叫醒。”她儿子上大学时，会早早起床去上班，却发现她已经醒了，正在看报纸。他对她说：“你知道吗，我从没见你在床上躺着过。” I was groggy and enjoyed listening to them swap stories, so I chimed in only occasionally. Johnson and White said that they didn’t need to take painkillers after surgeries. White talked about volunteering to fix people’s devices as part of a club of Apple users. 我迷迷糊糊的，很乐意听他们交换故事，所以只是偶尔插句话。约翰逊和怀特说，他们手术后不需要服用止痛药。怀特谈到，她作为苹果用户俱乐部的一员，自愿为人们修理设备。 I was still a little envious of short sleepers, but our conversation also served as a blunt reminder of how difficult it is to change one’s relationship to sleep. Johnson could no more make himself sleep through the night than I could get up every day for a 3 A.M. meeting. While they spoke, I thought about how nice it would be to get back into bed, and perhaps even to make up for lost time by sleeping in. There are some pleasures reserved for longer sleepers, I thought. 我还是有点羡慕那些睡眠少的人，但我们的对话也让我猛然意识到，改变自己与睡眠的关系有多难。约翰逊没法让自己一觉睡到天亮，就像我没法每天凌晨3点起床去开会一样。他们说话的时候，我在想，要是能回到床上就好了，说不定还能多睡会儿，把之前缺的觉补回来。我心想，有些乐趣是留给睡眠多的人的。 Had they squeezed more out of life in the time they’d had, I wondered? White said that, when she was younger, she’d needed the extra hours to run three real-estate companies and raise her children. She often organized her days by asking herself, What do I have left to do? Johnson had also felt a paradoxical time crunch. “I like to say that God knew I needed an extra three hours to keep up,” he said. 我不禁思索，他们是否在有限的时间里从生活中挖掘出了更多的价值？怀特说，年轻时，她需要额外的时间来经营三家房地产公司，还要抚养孩子。她常常通过自问“我还有什么事没做？”来安排自己的日常。约翰逊也有过一种矛盾的时间紧迫感。他说：“我常说，上帝知道我需要多三个小时才能跟上节奏。” But all three said that, in retirement, their experience of time has evolved. White now finds herself asking a more expansive question: What am I going to do? “Joanne sort of inspires me,” she said, of Osmond. “She’s so productive.” Osmond brushed her off, pointing out how frequently White volunteers, and I felt relieved that even short sleepers are self-conscious about how they use their time. 但这三人都表示，退休后，他们对时间的体验发生了变化。如今，怀特会问自己一个更宽泛的问题：我打算做什么？谈到奥斯蒙德时，她说：“乔安妮在某种程度上激励了我。”“她做事效率真高。”奥斯蒙德谦虚地回应，还指出怀特经常去做志愿者。我感到欣慰，因为即便是睡眠时间少的人，也会在意自己如何利用时间。 I got the feeling that the trio were happy to have found one another. Before we ended the call, White confessed to a bit of envy of her own. “It sounds wonderful to have a family that you can relate to,” she told Johnson and Osmond. “I don’t have anybody.” She turned to me and joked, “I feel like you created a friendship group for me.” 我感觉这三个人很高兴能结识彼此。在通话结束前，怀特坦承自己有点羡慕别人。她对约翰逊和奥斯蒙德说：“有个能亲密相处的家庭，听起来太美好了。”“我无依无靠。”她转向我开玩笑道，“感觉你为我组建了一个交友圈。” “You can contact me anytime you want,” Osmond chimed in. “More than likely, I'll be awake.” “你随时都能联系我。”奥斯蒙德插话道。“很可能，我那时候都醒着。”

临床研究

2026-02-10

·ioncology

240余项中国壁报将在EAU大会展示，一文共览学术前沿

编者按：2026年3月13日至16日，第41届欧洲泌尿外科学会年会（EAU26）将于英国伦敦召开。作为欧洲最具影响力的泌尿外科学术会议之一，会议共设置300余场专题论坛、手术直播演示及实践培训课程，集中展示全球泌尿外科领域的最新研究进展、临床实践经验与技术创新成果。中国泌尿外科的学术发展迅速，今年共有240余项相关研究入选壁报展示（尿路上皮癌47篇、前列腺癌55篇、肾癌37篇、结石37篇等），肿瘤瞭望-泌尿时讯特别整理（主要以相关领域及摘要号排序，如有遗漏和错误，欢迎留言），以飨读者。尿路上皮癌领域摘要号：P0199 英文标题：Predisposition to bladder cancer and active surveillance for low-risk non-muscle invasive bladder cancer 中文标题：膀胱癌易感因素及低风险非肌层浸润性膀胱癌的积极监测讲者：Jianyong Liu教授单位：深圳市肿瘤医院摘要号：P0200 英文标题：Life's Essential 8, genetic susceptibility, and risk of bladder cancer： A prospective cohort study 中文标题：生命必需的8种食物、遗传易感性和膀胱癌风险：一项前瞻性队列研究讲者：Liu Wei教授单位：北京大学第三医院摘要号：P0215 英文标题： Optimizing Candidates for Repeated TURBT in Non-Muscle-Invasive Bladder Cancer Using Urinary Low-Depth Sequencing： A Prospective Multicenter Study 中文标题：利用尿液低深度测序优化非肌层浸润性膀胱癌患者重复经尿道膀胱肿瘤切除术（TURBT）的候选者：一项前瞻性多中心研究讲者：Yang Xiao教授单位：南京医科大学第一附属医院摘要号：P0371 英文标题：Prospective Study on Biparametric MRI-based multi-planar VI-RADS for assessing muscle invasion in bladder cancer 中文标题：前瞻性研究：基于双参数磁共振成像的多平面VI-RADS评分在膀胱癌肌层浸润评估中的应用讲者：Yang Xiao教授单位：南京医科大学第一附属医院摘要号：P0372 英文标题：Development of a Deep Learning Model for MRI of Muscle - Invasive Bladder Cancer Based on Teacher - Student Knowledge Distillation 中文标题：基于师生知识提炼的肌肉浸润性膀胱癌MRI深度学习模型开发讲者：Hao Z.H.教授单位：南京鼓楼医院摘要号：P0375 英文标题：Intervention strategy selection for bladder preservation maintenance therapy in MIBC patients：a multi-center retrospective study 中文标题：肌层浸润性膀胱癌患者膀胱保留维持治疗干预策略的选择：一项多中心回顾性研究讲者：Ou Zhenyu教授单位：中南大学湘雅医院摘要号：P0380 英文标题：Peptides translation of IncLRRTM4 sustains the lymphatic metastasis of bladder cancer 中文标题：IncLRRTM4的肽翻译维持膀胱癌的淋巴转移讲者：Chen Changhao教授单位：中山大学孙逸仙纪念医院摘要号：P0477 英文标题：Ultrasound-Guided Endoscopic Combined IntraRenal Surgery for Nephron-Sparing Management of Upper Tract Urothelial Carcinoma： Technique and Outcomes 中文标题：超声引导下内镜联合肾内手术治疗上尿路尿路上皮癌肾单位保留疗法：技术与结果讲者：Ding Yingjie教授单位：上海交通大学医学院附属仁济医院摘要号：P0479 英文标题：Report on a Single-Center Experience with 24 Cases of Da Vinci Robot-Assisted Single-Port Laparoscopic Retroperitoneal Approach in Single-Position Nephroureterectomy 中文标题：单中心24例达芬奇机器人辅助单孔腹腔镜后腹膜入路单体位肾输尿管切除术经验报告讲者：Zheng Ming教授单位：南京医科大学附属第二医院摘要号：P0485 英文标题：Adjuvant Chemotherapy for pT2 Upper Tract Urothelial Carcinoma： Evidence from an Institutional Cohort and SEER Validation 中文标题：pT2期上尿路尿路上皮癌的辅助化疗：来自机构队列和SEER验证的证据讲者：鲍一歌教授单位：四川大学华西医院摘要号：P0539 英文标题：Mediator complex subunit 8 promotes bladder cancer progression via stearoyl-coA desaturase 中文标题：介导复合物亚基8通过硬脂酰辅酶A去饱和酶促进膀胱癌进展讲者：Zhang Haiyu教授单位：深圳大学附属第五医院摘要号：P0540 英文标题：Surveillance of the Genetic Signature in Circulating Tumor DNA for Guiding Adjuvant Chemotherapy in Urothelial Carcinoma： A Pilot Randomized Controlled Trial 中文标题：利用循环肿瘤DNA中的遗传特征监测指导尿路上皮癌辅助化疗：一项初步随机对照试验讲者：Na Y.教授单位：上海瑞金医院摘要号：P0541 英文标题：RPL19-25aa Cryptic Peptide Derived from circRPL19 Enhances Antitumor Immunity by Optimizing HLA–TCR Presentation in Bladder Cance 中文标题：源自circRPL19的RPL19-25aa隐蔽肽通过优化膀胱癌中的HLA-TCR呈递增强抗肿瘤免疫力讲者：Chen Changhao教授单位：中山大学孙逸仙纪念医院摘要号：P0546 英文标题：Predicting prognosis of muscle-Invasive bladder cancer patients using an artificial intelligence deep learning model 中文标题：利用人工智能深度学习模型预测肌层浸润性膀胱癌患者的预后讲者：张瑞赟教授单位：上海交通大学医学院附属仁济医院摘要号：P0547 英文标题：Integrative Molecular–Radiopathomic Characterization of AIRE-Driven Immune Subtypes in Bladder Cancer 中文标题：膀胱癌中AIRE驱动的免疫亚型的整合分子-放射病理学特征分析讲者：Liu Ji教授单位：同济大学附属第十人民医院摘要号：P0549 英文标题：A Multifunctional Patient-Derived Platform for Bladder Cancer： Assessing Chemotherapy Responses and CAR-T E cacy in Personalized Settings 中文标题：膀胱癌多功能患者衍生平台：在个性化环境中评估化疗反应和CAR-T疗法疗效讲者：Lu Junlin教授单位：中山大学孙逸仙纪念医院摘要号：P0551 英文标题：In Vivo Generation of Multiplexed CAR-Immune Cells via Virus-Mimicking Extracellular Vesicles for Bladder Cancer Therapy 中文标题：利用病毒模拟细胞外囊泡在体内生成多重CAR-免疫细胞用于膀胱癌治疗讲者：Zhan Hengji教授单位：中山大学孙逸仙纪念医院摘要号：P0552 英文标题：The CDK1/HIF-1α Axis Drives Glycolysis-Dependent Progression of FGFR3-Mutant Bladder Cancer 中文标题：CDK1/HIF-1α轴驱动FGFR3突变膀胱癌的糖酵解依赖性进展讲者：Ming Jie教授单位：首都医科大学附属北京友谊医院摘要号：P0553 英文标题：TMEM11 promotes cisplatin resistance by inhibiting BNIP3-mediated mitophagy in bladder cancer 中文标题：TMEM11通过抑制膀胱癌中BNIP3介导的线粒体自噬促进顺铂耐药性讲者：Li Fei教授单位：南方医科大学摘要号：P0558 英文标题：NMIBC：Surgery, intravesical therapy and follow-up 中文标题：非肌层浸润性膀胱癌：手术、膀胱内灌注治疗和随访讲者：Liu Zhenhua教授单位：中山大学肿瘤防治中心摘要号：P0569 英文标题：Bladder-sparing Therapy versus Upfront Radical Cystectomy for High-risk Non muscle-invasive Bladder Cancer： A Propensity Score Matching Analysis 中文标题：高危非肌层浸润性膀胱癌：膀胱保留治疗与根治性膀胱切除术的倾向评分匹配分析讲者：Li Pengchao教授单位：南京医科大学附属第一医院摘要号：P0573 英文标题：Randomized trial of urinary tumor DNA (ctDNA) testing-guided cystoscopy in high risk/very high-risk non-muscle-invasive bladder cancer (NMIBC)： TRUCE-LB02 中文标题：一项针对高危/极高危非肌层浸润性膀胱癌(NMIBC)患者的随机试验：尿液肿瘤DNA (ctDNA) 检测引导的膀胱镜检查：TRUCE-LB02 讲者：胡海龙教授单位：天津医科大学第二医院摘要号：P0638 英文标题：Robot-Assisted Partial Cystectomy, Distal Ureterectomy, and Reimplantation for Organ Preservation in Ureterovesical Junction Tumors 中文标题：机器人辅助部分膀胱切除术、远端输尿管切除术和再植术治疗输尿管膀胱连接部肿瘤以保留器官讲者：Lei Q.教授单位：上海交通大学医学院附属仁济医院摘要号：P0653 英文标题：Urinary exosomal netrin-1 as a novel biomarker for diagnosis and prognosis in bladder cancer：A multi-center study 中文标题：尿液外泌体网蛋白-1作为膀胱癌诊断和预后的新型生物标志物：一项多中心研究讲者：Yuyan Zhu教授单位：中国医科大学附属第一医院摘要号：P0654 英文标题：Thermo-sensitive Hydrogel System Enables Sustained Intravesical Delivery of Antibody–Drug Conjugates for Effective Treatment of Non–Muscle-Invasive Bladder Cancer 中文标题：热敏水凝胶系统可实现抗体-药物偶联物的持续膀胱内递送，从而有效治疗非肌层浸润性膀胱癌讲者：Fu Shi教授单位：昆明医科大学第二附属医院摘要号：P0655 英文标题：Intravesical Disitamab Vedotin (RC48) for BCG-Unresponsive High-Risk Non Muscle-Invasive Bladder Cancer： A Multicenter Phase I Trial 中文标题：膀胱内注射维迪西妥单抗(RC48)治疗BCG无反应的高危非肌层浸润性膀胱癌：一项多中心I期试验讲者：陈旭教授单位：中山大学孙逸仙纪念医院摘要号：P0656 英文标题：Organoid-on-a-Chip Guided Postoperative Intravesical Instillation for Early Bladder Cancer：Feasibility and Safety Study of EV-ADC and SG-ADC 中文标题：基于芯片类器官引导的术后膀胱内灌注治疗早期膀胱癌：EV-ADC和SG-ADC的可行性和安全性研究讲者：Zhang Lianghao教授单位：北京大学第一医院摘要号：P0657 英文标题：A triphenylamine-bridged bis-boronate probe for mitochondria-targeted and ROS bidirectional therapy of bladder cancer 中文标题：一种三苯胺桥联双硼酸酯探针用于膀胱癌的线粒体靶向和ROS双向治疗讲者：Yu Nengwang教授单位：山东大学齐鲁医院摘要号：P0659 英文标题：Androgen receptor blockade enhances intravesical BCG e cacy in non-muscle invasive bladder cancer： a propensity score-matched cohort study 中文标题：雄激素受体阻断可增强膀胱内卡介苗治疗非肌层浸润性膀胱癌的疗效：一项倾向评分匹配队列研究讲者：Ou Zhenyu教授单位：中南大学湘雅医院摘要号：P0662 英文标题：The Application Effect of Different Bladder Irrigation Solution Warming Methods in Postoperative Patients Undergoing Bladder Irrigation 中文标题：不同膀胱冲洗液加温方法在术后膀胱冲洗患者中的应用效果讲者：Hou Zhaolan教授单位：深圳市第二人民医院摘要号：P0664 英文标题：Prognostic Value of the Extent of Lymphadenectomy for Overall Survival Among Patients with Non-muscle Invasive Bladder Cancer, A Retrospective Cohort Study 中文标题：淋巴结清扫范围对非肌层浸润性膀胱癌患者总生存期的预后价值：一项回顾性队列研究讲者：Lai Chin-Hui教授单位：北京大学人民医院摘要号：P0736 英文标题：Anchoring Gene Therapy to the Bladder： A Mucoadhesive Microsphere System for Effective Intravesical TLR3 Gene Silencing in In ammatory Bladder Diseases 中文标题：将基因疗法锚定于膀胱：一种用于有效膀胱内TLR3基因沉默治疗炎症性膀胱疾病的粘膜粘附微球系统讲者：Xu Xueyuan教授单位：四川大学华西医院摘要号：P0868 英文标题：A Non-invasive MRI-based Multimodal Fusion Deep Learning Model (MF-DLM) for Predicting Overall Survival in Bladder Cancer： A Multicenter Retrospective Study 中文标题：基于非侵入性磁共振成像的多模态融合深度学习模型（MF-DLM）预测膀胱癌患者总生存期：一项多中心回顾性研究讲者：吕强教授单位：南京医科大学第一附属医院摘要号：P0877 英文标题：Efficacy and safety of neoadjuvant disitamab vedotin plus toripalimab, followed by response-adapted bladder sparing, in patients with muscle-invasive bladder cancer： A real-world study 中文标题：新辅助治疗方案为使用维迪西妥单抗联合特瑞普利单抗，随后根据疗效调整膀胱保留治疗，评估其在肌层浸润性膀胱癌患者中的疗效和安全性：一项真实世界研究讲者：顾良友教授单位：中国人民解放军总医院摘要号：P0901 英文标题：MRI radiomic phenotypes stratify response and define immune states in very high-risk non–muscle-invasive bladder cancer treated with tislelizumab plus nab-paclitaxel 中文标题：MRI放射组学表型可对接受替雷利珠单抗联合白蛋白紫杉醇治疗的极高危非肌层浸润性膀胱癌患者的治疗反应进行分层，并定义其免疫状态讲者：胡海龙教授单位：天津医科大学第二医院摘要号：P0902 英文标题：Mechanism of MCUB in Promoting Bladder Cancer Immune Evasion through Inhibiting PD-L1 Mitochondrial Autophagic Degradation 中文标题：MCUB通过抑制PD-L1线粒体自噬降解促进膀胱癌免疫逃逸的机制讲者：Li Fei教授单位：南方医科大学摘要号：P0903 英文标题：Predicting neoadjuvant chemotherapy response in bladder cancer patients using an artificial intelligence deep learning model 中文标题：利用人工智能深度学习模型预测膀胱癌患者新辅助化疗反应讲者：张瑞赟教授单位：上海交通大学医学院附属仁济医院摘要号：P0904 英文标题：Unlocking novel tumor-draining lymph node-derived T cell immunotherapy for bladder cancer through glycan labeling 中文标题：通过糖基化标记解锁用于膀胱癌的新型肿瘤引流淋巴结来源T细胞免疫疗法讲者：Wu Xiangyu教授单位：南京鼓楼医院摘要号：P0905 英文标题：KAT8-mediated NSUN2 lactylation promotes bladder cancer progression via m5C modification on HELZ2 中文标题：KAT8介导的NSUN2乳酸化通过HELZ2上的m5C修饰促进膀胱癌进展讲者：庄君龙教授单位：南京鼓楼医院摘要号：P0910 英文标题：Targeting lactate production or key lactylated proteins sensitizes bladder cancer to cisplatin therapy 中文标题：靶向乳酸生成或关键乳酸化蛋白可增强膀胱癌对顺铂治疗的敏感性讲者：Qian Jinqin教授单位：北京大学第一医院摘要号：P0911 英文标题：Development and preclinical evaluation of novel FGFR3-targeting antibody-drug conjugates in bladder cancer 中文标题：新型FGFR3靶向抗体药物偶联物在膀胱癌中的开发和临床前评估讲者：Wang Zhiping教授单位：兰州大学第二医院摘要号：P0912 英文标题：A spatially resolved atlas of upper tract urothelial carcinoma characterizes immunosuppressive niches driving tumor progression 中文标题：上尿路尿路上皮癌的空间分辨图谱揭示了驱动肿瘤进展的免疫抑制微环境讲者：Xiong Shengwei教授单位：北京大学第一医院摘要号：P0913 英文标题：Novel precision cancer model reveals epigenetic reprogramming induces variant histologic phenotype in upper tract urothelial carcinoma 中文标题：新型精准癌症模型揭示表观遗传重编程诱导上尿路尿路上皮癌组织学表型变异讲者：Zhang Shiyu教授单位：四川大学华西医院摘要号：P0914 英文标题：HER2 Protein Expression and its Clinicopathological Significance in Upper Urinary Tract Urothelial Carcinoma 中文标题：HER2蛋白表达及其在上尿路尿路上皮癌中的临床病理意义讲者：Bao Guan教授单位：北京大学第一医院摘要号：P0915 英文标题：Longitudinal utDNA Dynamics Predict Recurrence Risk in UTUC 中文标题： utDNA纵向动态变化可预测UTUC的复发风险讲者：左炜教授单位：北京大学第一医院摘要号：P0935 英文标题：Unlocking Senolytic-Immunotherapy in Bladder Cancer： A Multi-Omics Roadmap from Senescence Subtyping to Combination Therapy 中文标题：解锁膀胱癌衰老细胞清除免疫疗法：从衰老亚型到联合疗法的多组学路线图讲者：Liu Tao教授单位：中国医科大学附属第一医院摘要号：P0936 英文标题：Inhibiting α2,6-Sialylation Boosts Enfortumab Vedotin Response by Stabilizing Nectin-4 and Enhancing Macropinocytic Uptake in Bladder Cancer 中文标题：抑制α2,6-唾液酸化可通过稳定Nectin-4和增强膀胱癌巨胞饮作用来提高维恩妥尤单抗的疗效讲者：Cheng Bisheng教授单位：南方医科大学南方医院前列腺癌领域摘要号：P0044 英文标题：Early Prediction of Response to ADT Plus ARPI in mHSPC Using Interpretable Machine Learning on PSMA PET/CT： A Real-World Study 中文标题：利用可解释机器学习方法对转移性激素敏感性前列腺癌患者在接受雄激素剥夺疗法联合ARPI治疗后PSMA PET/CT影像上的疗效进行早期预测：一项真实世界研究讲者：蔡燚教授单位：中南大学湘雅医院摘要号：P0051 英文标题：First-in-human study of PSMA-targeted chimeric antigen receptor engineered natural killer cells for metastatic castration resistant prostate cancer 中文标题：首次人体研究：靶向PSMA的嵌合抗原受体工程化自然杀伤细胞治疗转移性去势抵抗性前列腺癌讲者：Kehao Pan教授单位：协和医院摘要号：P0052 英文标题：Bipolar androgen therapy sequential novel ARSI combined with PD-1 Inhibitor for patients with mCRPC：A single-arm prospective clinical study 中文标题：双相雄激素疗法序贯新型雄激素受体抑制剂联合PD-1抑制剂治疗转移性去势抵抗性前列腺癌患者：一项单臂前瞻性临床研究讲者：刘明教授单位：北京医院摘要号：P0053 英文标题：A Phase II Single-Arm, Open-Label Trial of Pamiparib in Metastatic Castration Resistant Prostate Cancer (mCRPC) Patients with Deleterious Germline or Somatic BRCA1/2 Alterations or Homologous Recombination De ciency (HRD) 中文标题：一项针对伴有有害种系或体细胞 BRCA1/2改变或同源重组缺陷(HRD)的转移性去势抵抗性前列腺癌(mCRPC)患者的帕米帕利II期单臂开放标签试验讲者：Zhao Diwei教授单位：中山大学肿瘤防治中心摘要号：P0054 英文标题：Long-term Clinical Outcomes and Genomic Predictors of PSMA-PET/CT-Guided Cytoreductive Progression-Directed Therapy in Patients with Oligoprogressive Castration-Resistant Prostate Cancer 中文标题：PSMA-PET/CT引导的细胞减灭进展导向治疗在寡进展去势抵抗性前列腺癌患者中的长期临床结果和基因组预测因子讲者：Shen Bing教授单位：同济大学附属第十人民医院摘要号：P0098 英文标题：The Negative Feedback of the Glutamine/Prostatitis Loop Identi ed among 1,400 Metabolites and Prostatitis via Mendelian Randomization 中文标题：通过孟德尔随机化方法，在1400种代谢物和前列腺炎中鉴定出谷氨酰胺/前列腺炎环路的负反馈讲者：Li Z教授单位：常州市第二人民医院摘要号：P0109 英文标题：A Transformer-Enabled Multimodal Framework Integrating MRI Radiomics and Clinical Features for Predicting Biochemical Recurrence After Radical Prostatectomy： Development and Multi-Institutional Validation 中文标题：基于Transformer的多模态框架整合MRI放射组学和临床特征，用于预测根治性前列腺切除术后的生化复发：开发和多中心验证讲者：陈锐教授单位：上海交通大学医学院附属仁济医院摘要号：P0110 英文标题：A single-cell spatial atlas of the PCa immune microenvironment identifies CCL18⁺ macrophages as a favorable subset 中文标题：前列腺癌免疫微环境的单细胞空间图谱显示，CCL18⁺巨噬细胞是一个有利的亚群。讲者：潘家骅教授单位：上海交通大学医学院附属仁济医院摘要号：P0111 英文标题：Hypoxia-Induced CAF-Derived CALR+ Extracellular Vesicles Drive Endothelial-Mesenchymal Transition and Aggressive Progression in Non-Metastatic Hormone-Sensitive Prostate Cancer via ITGA3/β1 Integrin Signaling 中文标题：缺氧诱导的CAF衍生CALR+细胞外囊泡通过ITGA3/β1整合素信号通路驱动非转移性激素敏感性前列腺癌的内皮-间质转化和侵袭性进展讲者：Dong Liang教授单位：上海交通大学医学院附属仁济医院摘要号：P0112 英文标题：ACOT8 Drives Senescent Cell Carcinogenesis by Promoting Histone Glutarylation in Prostate Epithelial Cells 中文标题：ACOT8通过促进前列腺上皮细胞中组蛋白戊二酰化来驱动衰老细胞癌变讲者：Chao Zheng教授单位：华中科技大学同济医学院附属同济医院摘要号：P0113 英文标题：Targeted GPX4 Degradation Using a Peptide-based PROTAC with SIAH1 as E3 Ligase Induces Ferroptosis in Prostate Cancer 中文标题：利用基于肽的PROTAC靶向降解GPX4，并以SIAH1作为E3连接酶，可诱导前列腺癌细胞发生铁死亡讲者：Zeng Na教授单位：华中科技大学同济医学院附属同济医院摘要号：P0114 英文标题：Prostatic Fluid DNA Methylation Biomarkers Enable High-Accuracy Prostate Cancer Diagnosis：A Prospective Pilot Study 中文标题：前列腺液DNA甲基化生物标志物可实现高精度前列腺癌诊断：一项前瞻性试点研究讲者：Peng yiji教授单位：陆军军医大学第一附属医院摘要号：P0115 英文标题：Luminal stem-like cells in high-risk/locally advanced prostate cancer promote resistance to hormonal therapy 中文标题：高危/局部晚期前列腺癌中的管腔干细胞样细胞促进对激素疗法的耐药性讲者：蔡燚教授单位：中南大学湘雅医院摘要号：P0116 英文标题：Chromatin conformational reprogramming by an enhancer RNA reveals an novel therapeutic in prostate cancer 中文标题：增强子RNA介导的染色质构象重编程揭示了前列腺癌的一种新型治疗方法讲者：Ma Sheng教授单位：华中科技大学同济医学院附属同济医院摘要号：P0117 英文标题：PSMA-Targeted Silicasome Co-delivery of Rucaparib and Tazemetostat Enhances Synergistic Treatment of Metastatic Castration-Resistant Prostate Cancer 中文标题：PSMA靶向硅体共递送Rucaparib和Tazemetostat可增强转移性去势抵抗性前列腺癌的协同治疗效果讲者：Huang Qiang教授单位：中国医科大学附属第一医院摘要号：P0118 英文标题：Co-targeting β-catenin and CTHRC1 disrupts the stromal-epithelial crosstalk to overcome enzalutamide resistance in CRPC 中文标题：联合靶向β-catenin和CTHRC1可破坏基质-上皮细胞间的相互作用，从而克服去势抵抗性前列腺癌（CRPC）中的恩扎卢胺耐药性讲者：庄君龙教授单位：南京鼓楼医院摘要号：P0119 英文标题：Bipolar androgen therapy reverses neuroendocrine lineage differentiation of prostate cancer through inhibition EZH2 中文标题：双相雄激素疗法通过抑制EZH2逆转前列腺癌的神经内分泌谱系分化讲者：Hou HuiMin教授单位：北京医院摘要号：P0120 英文标题：De Novo Design Delivers ACP3-Specific Macrocycle Peptide for ⁶⁸Ga-Based PET Imaging of Metastatic Castration-Resistant Prostate Cancer 中文标题：De Novo Design 开发出针对 ACP3 的特异性大环肽，用于基于⁶⁸Ga的PET成像，以检测转移性去势抵抗性前列腺癌讲者：Sihan Zhang教授单位：华中科技大学同济医学院附属同济医院摘要号：P0124 英文标题：CAF-derived epigenetic reprogramming drives prostate cancer metastasis via an EZH2-dependent enhancer activation program 中文标题：CAF来源的表观遗传重编程通过EZH2依赖的增强子激活程序驱动前列腺癌转移讲者：Yu Haofeng教授单位：浙江大学医学院附属邵逸夫医院摘要号：P0125 英文标题：Bone metastasis enrichment factor SHMT2 mediates immunosuppressive microenvironment and drives prostate cancer progression via the PI3K/AKT/mTOR pathway 中文标题：骨转移富集因子SHMT2通过PI3K/AKT/mTOR通路介导免疫抑制性微环境并驱动前列腺癌进展讲者：Lai Yiming教授单位：中山大学孙逸仙纪念医院摘要号：P0126 英文标题：PCBP2 drives immune evasion in recurrent prostate cancer via cGAS-STING pathway 中文标题：PCBP2通过cGAS-STING通路驱动复发性前列腺癌的免疫逃逸讲者：Zeng Zhou教授单位：中山大学孙逸仙纪念医院摘要号：P0152 英文标题：Evaluation of the feasibility and safety of darolutamide-based triplet therapy combined with cytoreductive prostatectomy in the treatment of metastatic hormone-sensitive prostate cancer 中文标题：评估以达罗他胺为基础的三联疗法联合细胞减灭性前列腺切除术治疗转移性激素敏感性前列腺癌的可行性和安全性讲者：Wang S.教授单位：江苏省人民医院摘要号：P0153 英文标题：Cytoreductive radical prostatectomy for patients with newly diagnosed high-volume metastatic prostate cancer： a multicentre, prospective cohort study 中文标题：对新诊断为高肿瘤负荷转移性前列腺癌患者进行细胞减灭性根治性前列腺切除术：一项多中心前瞻性队列研究讲者：Huang Cong教授单位：北京大学第一医院摘要号：P0154 英文标题：Redefining multimodal treatment in high-volume metastatic hormone-sensitive prostate cancer：Prospective evidence for robot-assisted cytoreductive prostatectomy following triplet systemic therapy 中文标题：重新定义高肿瘤负荷转移性激素敏感性前列腺癌的多模式治疗：机器人辅助细胞减灭性前列腺切除术联合三联全身治疗的前瞻性证据讲者：Hua Lixin教授单位：南京医科大学第一附属医院摘要号：P0156 英文标题：Effect of cytoreductive radical prostatectomy combined with hormonal therapy in patients with oligometastatic prostate cancera multicentered prospective non randomized control study 中文标题：细胞减灭性根治性前列腺切除术联合激素治疗对寡转移性前列腺癌患者疗效的多中心前瞻性非随机对照研究讲者：Xu Lei教授单位：复旦大学中山医院摘要号：P0160 英文标题：Efficacy and Safety of All-Site Radiotherapy in Combination with Standard of Care in High Gleason Score metastatic Prostate Cancer： Six-year Results from a Single Institution 中文标题：全部位放疗联合标准治疗治疗高格里森评分转移性前列腺癌的疗效和安全性：单中心六年结果讲者：Chen Huizhu教授单位：北京大学第一医院摘要号：P0345 英文标题：Impact of Neoadjuvant Hormonal Therapy Duration on PSA Response and Pathological Outcomes in High-Risk Prostate Cancer： A Retrospective Analysis 中文标题：新辅助激素治疗持续时间对高危前列腺癌PSA反应和病理结果的影响：一项回顾性分析讲者：Huang Yueting教授单位：广州医科大学附属第一医院摘要号：P0346 英文标题：Response-Adapted Neoadjuvant Intensi cation with Abiraterone and LHRH Agonist ± Docetaxel Before Radical Prostatectomy in High-Risk Localized Prostate Cancer： A Prospective Cohort Study Emulating a Target Trial 中文标题：高危局限性前列腺癌根治性前列腺切除术前采用阿比特龙和促性腺激素释放激素激动剂±多西他赛进行反应适应性新辅助强化治疗：一项模拟TARGET试验的前瞻性队列研究讲者：Wang Xuan教授单位：北京医院摘要号：P0349 英文标题：Efficacy of neoadjuvant docetaxel + darolutamide versus darolutamide in patients with locally advanced prostate cancer：A phase II trial in China 中文标题：新辅助多西他赛联合达罗他胺与单用达罗他胺治疗局部晚期前列腺癌患者的疗效比较：一项在中国开展的II期临床试验讲者：Pei Xinqi教授单位：西安交通大学第一附属医院摘要号：P0435 英文标题：One plane or two? A randomized comparison of biplanar versus monoplanar prostate biopsy strategies 中文标题：单平面还是双平面？双平面与单平面前列腺活检策略的随机对照研究讲者：Zeng Zhou教授单位：中山大学孙逸仙纪念医院摘要号：P0439 英文标题：Targeted and Perilesional Biopsy versus Combined Targeted and Systematic Biopsy for Biopsy-Naïve Patients with PIRADS 3 Lesions： A Randomized Clinical Trial 中文标题：针对初次接受活检的PIRADS 3病变患者，靶向活检和病灶周围活检与联合靶向活检和系统活检的疗效比较：一项随机临床试验讲者：邓睿逸教授单位：北京大学第一医院摘要号：P0441 英文标题：Identification and prognostic sign chance of tertiary lymphoid structures in prostate cancer 中文标题：前列腺癌中三级淋巴结构的识别和预后征象讲者：董强教授单位：四川大学华西医院摘要号：P0442 英文标题：Development and clinical validation of a urine-based DNA methylation assay for noninvasive detection of prostate cancer： a prospective study 中文标题：开发和临床验证一种基于尿液的DNA甲基化检测方法用于无创检测前列腺癌：一项前瞻性研究讲者：邢念增教授单位：国家癌症中心摘要号：P0443 英文标题：Comprehensive single-cell spatial pro ling of prostate cancer reveals ecosystem dynamics in 23.5 million cells 中文标题：对前列腺癌进行全面的单细胞空间分析，揭示了2350万个细胞中的生态系统动态讲者：潘家骅教授单位：上海交通大学医学院附属仁济医院摘要号：P0448 英文标题：Prostate Health Index Combined with Pi-Rads Score Enhances Prostate Cancer Diagnosis： Insights From a Large Chinese Cohort 中文标题：前列腺健康指数联合Pi-Rads评分可提高前列腺癌的诊断率：来自中国大型队列研究的启示讲者：Zhong X.Y.教授单位：华中科技大学同济医学院附属同济医院摘要号：P0451 英文标题：Coupling MRI Voxel-wise Spatial Heterogeneity with TRUS Dynamic Deep Features Endows High Discernability for Clinically Signi cant Prostate Cancer 中文标题：将磁共振成像体素级空间异质性与经直肠超声动态深部特征相结合，可显著提高对临床显著性前列腺癌的鉴别能力讲者：Lam S.K.教授单位：中国香港理工大学摘要号：P0526 英文标题：Combined Pudendal Nerve Electroacupuncture and Botulinum Toxin A Injection for Post-Prostatectomy Mixed Urinary Incontinence： A Prospective Study 中文标题：阴部神经电针联合A型肉毒杆菌毒素注射治疗前列腺切除术后混合性尿失禁：一项前瞻性研究讲者：Lyu Rong教授单位：上海市浦东新区公利医院摘要号：P0527 英文标题：Transurethral bladder neck resection combines with intraoperative and postoperative regular injection of triamcinolone acetonide for the treatment of bladder neck contracture after robot-assisted radical prostatectomy 中文标题：经尿道膀胱颈切除术联合术中及术后定期注射曲安奈德治疗机器人辅助根治性前列腺切除术后膀胱颈挛缩讲者：Yang Lin教授单位：西安交通大学第一附属医院摘要号：P0529 英文标题：Predictors of De Novo Overactive Bladder After Radical Prostatectomy for Prostate Cancer： Can Retzius-Sparing Robot-Assisted Radical Prostatectomy Reduce Its Incidence? 中文标题：前列腺癌根治性前列腺切除术后新发膀胱过度活动症的预测因素：保留Retzius韧带的机器人辅助根治性前列腺切除术能否降低其发生率？讲者：Zheng Wen-Cai教授单位：福建医科大学附属第一医院摘要号：P0530 英文标题：Suicide Risk in Prostate Cancer Patients： Epidemiological Trends and a Predictive Modeling 中文标题：前列腺癌患者的自杀风险：流行病学趋势和预测模型讲者：Yang Yuxuan教授单位：华中科技大学同济医学院附属同济医院摘要号：P0532 英文标题：Precision irreversible electroporation for localized prostate cancer guided by a novel system based on artificial intelligence and electromagnetic navigation system 中文标题：基于人工智能和电磁导航系统的新型系统引导的精准不可逆电穿孔治疗局部前列腺癌讲者：Wang Miao教授单位：北京医院摘要号：P0618 英文标题：Integrating EndoScell into NeuroSAFE： A Real-Time Imaging Approach for Precision Prostate Surgery 中文标题：将EndoScell整合到NeuroSAFE中：一种用于精准前列腺手术的实时成像方法讲者：He Hongmiao教授单位：上海长海医院摘要号：P0626 英文标题：Signi cant Asymmetry in Positive Surgical Margins During Robot-Assisted Radical Prostatectomy：A Higher Incidence on the Left Side 中文标题：机器人辅助根治性前列腺切除术中阳性切缘的显著不对称性：左侧发生率更高讲者：Yao Kaifeng教授单位：北京大学第一医院摘要号：P0627 英文标题：Development and Validation of a Machine Learning–Enhanced Preoperative Nomogram for Predicting Positive Surgical Margins after Radical Prostatectomy 中文标题：开发和验证一种基于机器学习的术前列线图，用于预测根治性前列腺切除术后阳性切缘讲者：Zhou Jingcheng教授单位：北京大学第一医院摘要号：P0687 英文标题：Burden and trend of early onset prostate cancer in BRICS from 1990 to 2021 and predictions for 2040 中文标题：1990年至2021年金砖国家早发性前列腺癌的负担和趋势以及2040年的预测讲者：Zhang Jinhao教授单位：复旦大学附属华山医院摘要号：P0688 英文标题：COMPACT Study：Real-World Impact of Community-Based PSA Screening on Prostate Cancer in China 中文标题：COMPACT研究：社区PSA筛查对中国前列腺癌的真实世界影响讲者：古迪教授单位：广州医科大学附属第一医院摘要号：P0733 英文标题： Risk Factors and Prediction Model for Bladder Neck Contracture after Transurethral Laser Enucleation of the Prostate 中文标题：经尿道激光前列腺剜除术后膀胱颈挛缩的危险因素及预测模型讲者：Yuan Qing教授单位：中国人民解放军总医院摘要号：P0830 英文标题：A Qualitative Study on the Avoidance Behavior of Seeking Help for Sexual Health after Radical Prostatectomy from the Perspectives of Patients and Physicians 中文标题：从患者和医生的角度对根治性前列腺切除术后患者回避寻求性健康帮助的行为进行定性研究讲者：Peng Man教授单位：中山大学孙逸仙纪念医院摘要号：P0833 英文标题：Perineural Invasion Density： A Novel Quantitative Prognostic Marker in Prostate Cancer 中文标题：神经周围浸润密度：前列腺癌的一种新型定量预后标志物讲者：Liu BoHao教授单位：中山大学附属第三医院摘要号：P0838 英文标题：A comprehensive analysis of the role and potential targets of plasticizer exposure in prostate cancer progression： evidence from Chinese and American populations and preclinical studies. 中文标题：对增塑剂暴露在前列腺癌进展中的作用和潜在靶点进行全面分析：来自中国和美国人群以及临床前研究的证据讲者：Zhou Xianghong教授单位：四川大学华西医院摘要号：P0842 英文标题：Post-diagnosis smoking and risk of all-cause and prostate cancer-specific mortality： Evidence from the UK Biobank 中文标题：确诊后吸烟与全因死亡率和前列腺癌特异性死亡率风险：来自英国生物银行的证据讲者：Yang Xiangwei教授单位：中山大学附属第七医院摘要号：P0845 英文标题：Construction of an AI model for predicting postoperative ISUP grade of prostate cancer based on multimodal data 中文标题：基于多模态数据构建预测前列腺癌术后ISUP分级的AI模型讲者：Zhong Haitao教授单位：中山大学孙逸仙纪念医院摘要号：P0847 英文标题：Diagnostic accuracy of 18F-PSMA PET-targeted biopsy versus multiparametric MRI-targeted biopsy： a prospective open-label clinical study 中文标题：18F-PSMA PET靶向活检与多参数MRI靶向活检的诊断准确性：一项前瞻性开放标签临床研究讲者：董樑教授单位：上海交通大学医学院附属仁济医院摘要号：P0853 英文标题：An Interpretable Machine Learning Model to Address the Diagnostic Challenge of Clinically Significant Prostate Cancer in the PSA Gray Zone： A Multicenter Study 中文标题：利用可解释的机器学习模型解决PSA灰色区域临床显著性前列腺癌的诊断难题：一项多中心研究讲者：Ruan Mingjian教授单位：北京大学肿瘤医院摘要号：P0918 英文标题：MRI Artificial Intelligence in Prostate Cancer Precision Diagnosis： AIM-PRO Within-patient Non-Inferiority Clinical Trial 中文标题：磁共振人工智能在前列腺癌精准诊断中的应用：AIM-PRO患者自身非劣效性临床试验讲者：邓睿逸教授单位：北京大学第一医院肾癌领域摘要号：P0073 英文标题：Construction of an Early Diagnostic Model for Von Hippel-Lindau Syndrome Renal Cell Carcinoma (VHL-RCC) Lipid Biomarkers Using Machine Learning and AI Algorithms to Analyze Blood and Tissue Metabolomics 中文标题：利用机器学习和人工智能算法分析血液和组织代谢组学，构建冯·希佩尔-林道综合征肾细胞癌（VHL-RCC）脂质生物标志物的早期诊断模型讲者：Chen Xiaolin教授单位：北京大学第一医院摘要号：P0076 英文标题： Clinicopathologic and prognosis of 30 patients with FH-de cient Renal Cell carcinoma： a single-center retrospective study 中文标题：30例FH缺乏型肾细胞癌患者的临床病理及预后：一项单中心回顾性研究讲者：Bai Junjie教授单位：福建医科大学省立临床医学院摘要号：P0077 英文标题：Differential Belzutifan response driven by distinct VHL exon deletions： From molecular mechanisms to translational validation in renal cell carcinoma 中文标题：由不同的VHL外显子缺失驱动的Belzutifan反应差异：从分子机制到肾细胞癌的转化验证讲者：Bao YuHang教授单位：北京大学第一医院摘要号：P0079 英文标题：Hotspot Mutations and Tumor Risk in VHL Syndrome： Genotype-Phenotype Analysis of a Large Patient Cohort 中文标题：VHL综合征热点突变与肿瘤风险：大型患者队列的基因型-表型分析讲者：Wang Chuandong教授单位：北京大学第一医院摘要号：P0081 英文标题： Androgen–Receptor Axis Drives Tumor Initiation in VHL-Associated Early-Onset Renal Cell Carcinoma： Mechanistic Basis and Preventive Implications 中文标题：雄激素受体轴驱动VHL相关早发性肾细胞癌的肿瘤发生：机制基础和预防意义讲者：Song Zheng教授单位：北京大学第一医院摘要号：P0082 英文标题： Development of a Novel 68Ga-Labeled Radiotracer Targeting Carbonic Anhydrase IX for Diagnosis of Clear Cell Renal Cell Carcinoma 中文标题：开发一种新型的靶向碳酸酐酶IX的68Ga标记放射性示踪剂用于透明细胞肾细胞癌的诊断讲者：Liu Tao教授单位：北京大学第一医院摘要号：P0084 英文标题：Pre-Diagnostic Plasma Proteomics Pro le Uncovers New Biomarkers and Mechanistic Insights for Incident Kidney Cancer 中文标题：诊断前血浆蛋白质组学分析揭示了肾癌发病的新生物标志物和机制见解讲者：Wen Liu教授单位：国家癌症中心摘要号：P0085 英文标题：Decoding Metabolic Causality Across Kidney Cancer Subtypes： An Integrative Mendelian Randomization and Metabolomic Validation Study 中文标题：解码肾癌亚型代谢因果关系：一项整合孟德尔随机化和代谢组学验证的研究讲者：Wang Zheng教授单位：上海交通大学医学院附属第九人民医院摘要号：P0090 英文标题：Identi cation of a novel pyroptosis gene signature for prognosis prediction in patients with clear cell renal cell carcinoma 中文标题：鉴定一种新的细胞焦亡基因特征用于透明细胞肾细胞癌患者的预后预测讲者：Yang Jie教授单位：四川大学华西医院摘要号：P0169 英文标题：BRCA2 Expression Predicts Immune Infiltration and Tumor Progression in Kidney Chromophobe and Renal Papillary Cell Carcinoma 中文标题：BRCA2表达可预测肾嗜铬细胞癌和肾乳头状细胞癌的免疫浸润和肿瘤进展讲者：Wu Yupeng教授单位：南方医科大学第三附属医院摘要号：P0173 英文标题： An International Multidisciplinary Delphi Consensus Statement on De nition, Classi cation, and Characterization of Oligometastatic Renal Cell Carcinoma to Guide Treatment Decisions 中文标题：关于寡转移性肾细胞癌的定义、分类和特征的国际多学科德尔菲共识声明，旨在指导治疗决策讲者：Wu Zhenjie教授单位：上海长海医院摘要号：P0176 英文标题：Development and Validation of a Prognostic Nomogram Based on Clinicopathological Characteristics of Renal Cell Carcinoma in Patients Under 30 Years old ： A 12-Year Single-Center Study 中文标题：基于30岁以下肾细胞癌患者临床病理特征的预后列线图的构建与验证：一项为期12年的单中心研究讲者：Junnan Xu教授单位：中国人民解放军总医院摘要号：P0179 英文标题：Establishment and external validation of a prognostic prediction model for renal epithelioid angiomyolipoma： A multicenter retrospective study 中文标题：建立并外部验证肾上皮样血管平滑肌脂肪瘤预后预测模型：一项多中心回顾性研究讲者：Le Qu教授单位：南京大学医学院附属金陵医院摘要号：P0393 英文标题：Multi-center real-world evidence on preoperative systemic therapy for clear cell renal cell carcinoma patients with inferior vena cava tumor thrombus 中文标题：多中心真实世界证据表明，对于伴有下腔静脉瘤栓的透明细胞肾细胞癌患者，术前全身治疗有效讲者：顾良友教授单位：中国人民解放军总医院摘要号：P0395 英文标题：A Phase II Study of Neoadjuvant Lenvatinib and Cadonilimab in High-Risk Localized and Locally Advanced Renal Cell Carcinoma (POST-RCC-01)： Achieving Primary Endpoint in Simon’s First Stage 中文标题：一项针对高危局限性及局部晚期肾细胞癌的新辅助仑伐替尼联合卡度尼利单抗治疗的II期研究（POST-RCC-01）：达到西蒙第一阶段的主要终点讲者：Dong Wen教授单位：中山大学孙逸仙纪念医院摘要号：P0397 英文标题：Efficacy and safety of adjuvant penpulimab in very high-risk clear cell renal cell carcinoma：A prospective, controlled, phase II trial 中文标题：派安普利单抗辅助治疗极高危透明细胞肾细胞癌的疗效和安全性：一项前瞻性、对照、II期试验讲者：顾良友教授单位：中国人民解放军总医院摘要号：P0454 英文标题：Efficacy and Safety of Targeted-Immunotherapy With or Without Stereotactic Radiotherapy for Recurrent/Metastatic Renal Cell Carcinoma： Interim Analysis of a Multicenter Ambidirectional Cohort Study 中文标题：靶向免疫疗法联合或不联合立体定向放射疗法治疗复发/转移性肾细胞癌的疗效和安全性：一项多中心双向队列研究的中期分析讲者：Hu Ke教授单位：北京大学第一医院摘要号：P0956 英文标题：Predictive factors and a nomogram for haemodynamic instability during operation in patients with pheochromocytomas and paragangliomas 中文标题：嗜铬细胞瘤和副神经节瘤患者术中血流动力学不稳定的预测因素及列线图讲者：Jiang Xuewen教授单位：山东大学齐鲁医院摘要号：P0957 英文标题：Intraoperative hemodynamic instability in patients with clinically silent pheochromocytoma and paraganglioma： A multicenter real-world study 中文标题：临床无症状嗜铬细胞瘤和副神经节瘤患者术中血流动力学不稳定：一项多中心真实世界研究讲者：Cheng Kai教授单位：中南大学湘雅医院摘要号：P0958 英文标题：Phenotypic Characteristics of Patients with FGFR1-Mutant Pheochromocytoma/ Paraganglioma： A Multicenter Retrospective Study Based on 1001 Cases 中文标题：FGFR1突变型嗜铬细胞瘤/副神经节瘤患者的表型特征：一项基于1001例病例的多中心回顾性研究讲者：Li Zhiwei教授单位：中山大学第五医院摘要号：P0959 英文标题：Rede ning surgical boundaries： outcomes of minimally invasive adrenalectomy in large pheochromocytomas. 中文标题：重新界定外科手术边界：微创肾上腺切除术治疗大型嗜铬细胞瘤的疗效讲者：Kong Jianqiu教授单位：中山大学孙逸仙纪念医院摘要号：P0960 英文标题： Comparative Analysis of Laparoscopic Perioperative Hemodynamics inPseudohypoxic versus Kinase-Signaling Pheochromocytoma/Paraganglioma Patients 中文标题：腹腔镜手术治疗假性缺氧型嗜铬细胞瘤/副神经节瘤与激酶信号通路型嗜铬细胞瘤/副神经节瘤患者围手术期血流动力学的比较分析讲者：Wang Yong教授单位：中山大学附属第五医院摘要号：P0961 英文标题：Comparative Outcomes of Radiotherapy and Interventional Therapy for Adrenal Oligometastases： A Multicenter Retrospective Study 中文标题：肾上腺寡转移瘤放射治疗与介入治疗疗效比较：一项多中心回顾性研究讲者：Guo Shengjie教授单位：中山大学肿瘤防治中心摘要号：P0966 英文标题：Retroperitoneal Versus Transperitoneal Laparoscopic Adrenalectomy for Adrenocortical Carcinoma： A Retrospective Comparative Study 中文标题：腹膜后与经腹膜腹腔镜肾上腺切除术治疗肾上腺皮质癌：一项回顾性比较研究讲者：Liu Xiaoyang教授单位：四川大学华西医院摘要号：P0988 英文标题：Multi-Omics profiling of long noncoding RNAs in clear cell renal cell carcinoma for characterization and clinical applications 中文标题：利用多组学方法分析透明细胞肾细胞癌中的长链非编码RNA，以进行表征和临床应用讲者：Ding Yuhong教授单位：华中科技大学同济医学院附属同济医院摘要号：P0993 英文标题：A Soulangianolide A-Derived Inhibitor Disrupts the FAM120A–SREBP1–PPARγ Metabolic Loop and Synergizes with HIF-2α Blockade in Clear Cell Renal Cell Carcinoma 中文标题：Soulangianolide A衍生的抑制剂可破坏FAM120A–SREBP1–PPARγ代谢环路，并与 HIF-2α阻断剂在透明细胞肾细胞癌中产生协同作用讲者：Song Zheng教授单位：北京大学第一医院摘要号：P0995 英文标题：Targeting tRNA-Derived Fragment tRF-21 Enhances Immunotherapy Efficacy by Reducing PMN-MDSCs Accumulation in Renal Cell Carcinoma 中文标题：靶向tRNA衍生片段tRF-21可通过减少肾细胞癌中PMN-MDSC的积累来增强免疫疗法的疗效讲者：Qin Xin教授单位：山东大学齐鲁医院摘要号：P0999 英文标题：GPNMB+ Tumor-Associated Macrophages Drive CD8+ T Cell Exhaustion to Facilitate Clear Cell Renal Cell Carcinoma Progression 中文标题：GPNMB+肿瘤相关巨噬细胞驱动CD8+T细胞耗竭，促进透明细胞肾细胞癌进展讲者：Tao Yi教授单位：上海交通大学医学院附属仁济医院摘要号：P1004 英文标题：Integrative multi-omics profiling reveals molecular mechanisms and targetable pathways of Belzutifan resistance in renal cell carcinoma 中文标题：整合多组学分析揭示肾细胞癌中贝组替凡耐药的分子机制和可靶向通路讲者：Bao YuHang教授单位：北京大学第一医院摘要号：P1007 英文标题：Nuclear translocation of TFEB enhances autophagy and PD-L1 expression promoting invasion, metastasis, and immune escape of FH-deficient renal cell carcinoma 中文标题：TFEB的核转位增强自噬和PD-L1表达，促进FH缺陷型肾细胞癌的侵袭、转移和免疫逃逸讲者：Tao Wang教授单位：首都医科大学附属北京友谊医院摘要号：P1011 英文标题：CENPT Inhibits Ferroptosis and Promotes Renal Cell Carcinoma Progression via a CENPT-GCLC-GSH Positive Feedback Loop 中文标题：CENPT通过CENPT-GCLC-GSH正反馈环路抑制铁死亡并促进肾细胞癌进展讲者：Han Yang教授单位：陆军军医大学第一附属医院摘要号：P1012 英文标题：Tumor-infiltrating intracellular microbiota promote metastatic colonization in clear cell renal cell carcinoma 中文标题：肿瘤浸润性细胞内微生物群促进透明细胞肾细胞癌的转移性定植讲者：You Bosen教授单位：哈尔滨医科大学第二附属医院摘要号：P1014 英文标题：The role of piR-1742 in malignant progression and clinical translation of renal rell carcinoma 中文标题：piR-1742在肾细胞癌恶性进展和临床转化中的作用讲者：Wentao Zhang教授单位：同济大学附属第十人民医院摘要号：P1016 英文标题：A TLS-Based Molecular Signature Predicts Prognosis and Immune Escape in Clear Cell Renal Cell Carcinoma 中文标题：基于TLS的分子特征可预测透明细胞肾细胞癌的预后和免疫逃逸讲者：Liu Wei教授单位：北京大学第三医院摘要号：P1019 英文标题：Spatially Resolved Myeloid Cell Driven Tissue Reorganization Shapes Immunotherapy Outcomes in Advanced Renal Cell Carcinoma 中文标题：空间分辨的髓系细胞驱动的组织重组影响晚期肾细胞癌的免疫治疗结果讲者：翟炜教授单位：上海交通大学医学院附属仁济医院摘要号：P1020 英文标题：Development and Validation of a Novel Plasma Metabolomic Signature for the Detection of Renal Cell Carcinoma 中文标题：开发和验证一种用于检测肾细胞癌的新型血浆代谢组学特征讲者：Rui Rui教授单位：北京大学第一医院摘要号：P1023 英文标题：Metabolic Reprogramming in Early-Onset VHL-Associated Clear Cell Renal Cell Carcinoma： A Multi-Omics Study Reveals Amino Acid Oxidation and Lipid Remodeling as Key Drivers of Systemic Rewiring 中文标题：早期发病的VHL相关透明细胞肾细胞癌的代谢重编程：一项多组学研究揭示氨基酸氧化和脂质重塑是系统性重编程的关键驱动因素讲者：Song Zheng教授单位：北京大学第一医院结石领域摘要号：P0005 英文标题：Evaluation of new-generation systemic immune markers for predicting positive urine culture in urolithiasis patients 中文标题：评估新一代系统性免疫标志物在预测泌尿系结石患者尿培养阳性中的作用讲者：Li Chunpeng教授单位：天津医科大学第二医院摘要号：P0006 英文标题：Species-Level Pro ling Reveals Two Distinct Urobiome Clusters in Unilateral Stone Formers 中文标题：物种水平的Proling分析揭示了单侧结石患者中两种截然不同的尿微生物群落讲者：Hong Sen-Yuan教授单位：武汉同济医院摘要号：P0010 英文标题： Bidirectional Association Between Kidney Stones and Atherosclerosis： A Study on Mediation, Genetics, and Risk Prediction 中文标题：肾结石与动脉粥样硬化的双向关联：一项关于中介作用、遗传学和风险预测的研究讲者：He Zhaohui教授单位：中山大学附属第八医院摘要号：P0013 英文标题：A Mouse Model Study on Gene Therapy for Primary Hyperoxaluria Type 3 Using Base Editing Technology 中文标题：利用碱基编辑技术进行原发性高草酸尿症3型基因治疗的小鼠模型研究讲者：Ge Yucheng教授单位：首都医科大学附属北京友谊医院摘要号：P0017 英文标题：A novel synbiotic formulation prevents calcium oxalate stones by educating gut microbiota 中文标题：一种新型合生元配方通过调节肠道菌群来预防草酸钙结石讲者：Xun Yang教授单位：华中科技大学同济医学院附属同济医院摘要号：P0018 英文标题：Gut microbiome and metabolome signatures in renal stone recurrence： A multiomics study 中文标题：肾结石复发中的肠道微生物组和代谢组特征：一项多组学研究讲者：Dang Kai教授单位：首都医科大学北京友谊医院摘要号：P0248 英文标题： Preoperative prediction of factors associated with impacted ureteral stones and construction of a nomogram model 中文标题：术前预测与输尿管结石嵌顿相关的因素并构建列线图模型讲者：Xinyu Shi教授单位：郑州大学第二附属医院摘要号：P0252 英文标题： Development of Automated AI Extracorporeal Shock Wave Lithotripsy Robot 中文标题：自动化人工智能体外冲击波碎石机器人的研发讲者：Li Cong教授单位：华中科技大学同济医学院附属同济医院摘要号：P0289 英文标题： The Association Between Plasma Fatty Acid Levels and the Risk of Kidney Stone Formation： A Prospective Cohort Study Based on the UK Biobank 中文标题：血浆脂肪酸水平与肾结石形成风险之间的关联：一项基于英国生物银行的前瞻性队列研究讲者：He Zhaohui教授单位：中山大学附属第八医院摘要号：P0290 英文标题： Association between sarcopenic obesity and kidney stones： results from a UK Biobank prospective cohort study 中文标题：肌少症性肥胖与肾结石之间的关联：一项英国生物银行前瞻性队列研究的结果讲者：He Zhaohui教授单位：中山大学附属第八医院摘要号：P0291 英文标题：Caffeine and its metabolites inhibit calcium oxalate stone formation through the NRF2/HO-1 pathway 中文标题：咖啡因及其代谢产物通过NRF2/HO-1通路抑制草酸钙结石的形成讲者：Dang Kai教授单位：首都医科大学附属北京友谊医院摘要号：P0292 英文标题：Novel marine-derived peptide FWEK prevents calcium oxalate stone formation via Keap1-Nrf2 activation： From computational discovery to in vivo validation 中文标题：新型海洋来源肽FWEK通过激活Keap1-Nrf2通路预防草酸钙结石形成：从计算机发现到体内验证讲者：Xu Hongbo教授单位：苏州大学附属第四医院摘要号：P0294 英文标题：The Hippo-YAP1/TEAD1-SLC7A5 axis： Uncovering a novel therapeutic target for oxalate-induced renal tubular ferroptosis 中文标题：Hippo-YAP1/TEAD1-SLC7A5轴：揭示草酸盐诱导的肾小管铁死亡的新型治疗靶点讲者：Junyi Yang教授单位：华中科技大学同济医学院附属同济医院摘要号：P0295 英文标题：Targeting Ferroptosis and Macrophage-to-Myofibroblast Transition in Renal Fibrosis Induced by Urinary Obstruction： Deciphering the Multi Target Therapeutic Effects of A Modi ed Carbon Dots 中文标题：靶向尿路梗阻诱导的肾纤维化中的铁死亡和巨噬细胞向肌成纤维细胞的转变：解析修饰碳点的多靶点治疗作用讲者：Kaijie Wu教授单位：西安交通大学第一附属医院摘要号：P0296 英文标题：High-fat diet exacerbates calcium oxalate crystal-induced kidney injury via inhibiting Echs1-mediated fatty acid metabolism 中文标题：高脂饮食通过抑制Echs1介导的脂肪酸代谢，加剧草酸钙晶体引起的肾损伤讲者：Chen Yue教授单位：天津医科大学第二医院摘要号：P0297 英文标题： Iteratively Designed Multifunctional Carbon Dots Nanoplatform for Targeted Celastrol Delivery and Combination Therapy of Kidney Stones 中文标题：迭代设计的多功能碳点纳米平台用于靶向递送雷公藤内酯醇和联合治疗肾结石讲者：Zhu Xiaoyu教授单位：华中科技大学同济医学院附属同济医院摘要号：P0298 英文标题：Gut microbiota-mediated tryptophan metabolism attenuates calcium oxalate nephropathy by suppressing renal tubular cell apoptosis through the AhR/SOCS3/STAT1 axis 中文标题：肠道菌群介导的色氨酸代谢通过AhR/SOCS3/STAT1轴抑制肾小管细胞凋亡，从而减轻草酸钙肾病讲者：Li Ya教授单位：四川大学华西医院摘要号：P0300 英文标题： Mechanism of obesity induced ACSM5 de ciency promoting calcium oxalate induced renal tubular epithelial cell injury 中文标题：肥胖诱导的ACSM5缺乏促进草酸钙诱导的肾小管上皮细胞损伤的机制讲者：Xiangyang Yao教授单位：深圳大学第一附属医院摘要号：P0301 英文标题：A Role for Endoplasmic Reticulum Stress in Calcium Oxalate Crystal-Induced Renal Injury： Insights from Transcriptome Sequencing 中文标题：内质网应激在草酸钙晶体诱导的肾损伤中的作用：来自转录组测序的启示讲者：Hong Sen-Yuan教授单位：华中科技大学同济医学院附属同济医院摘要号：P0302 英文标题：A Bi dobacterium metabolite inhibits kidney stone formation by dampening T cell activation 中文标题：细菌代谢产物通过抑制T细胞活化来抑制肾结石形成讲者：Yang Yuanyuan教授单位：华中科技大学同济医学院附属同济医院摘要号：P0303 英文标题：The role and mechanism of alternative splicing of PKM2 by RNA binding protein LGALS3 in metabolic reprogramming of renal tubular epithelial cells in renal injury induced by calcium oxalate crystals 中文标题：草酸钙晶体诱导肾损伤中，RNA结合蛋白LGALS3介导PKM2选择性剪接在肾小管上皮细胞代谢重编程中的作用和机制讲者：heng Fan教授单位：武汉大学人民医院摘要号：P0304 英文标题：Extracellular Vesicle-circPHAF1 Promotes the Formation of Calcium Oxalate Urolithiasis by Mediating the Recruitment and Polarization of Macrophages 中文标题：细胞外囊泡-circPHAF1通过介导巨噬细胞的募集和极化促进草酸钙尿路结石的形成讲者：Yongda Liu教授单位：广州医科大学附属第一医院摘要号：P0305 英文标题：Machine learning analysis of plasma proteomics identifies CALCA and STC1 as early biomarkers for urolithiasis 中文标题：机器学习分析血浆蛋白质组学发现CALCA和STC1可作为泌尿系结石的早期生物标志物讲者：Tang Runhua教授单位：北京医院摘要号：P0306 英文标题：A Multi-Omics-Based Predictive Model for Kidney Stone Formation： Integrating Gut Microbial and Metabolic Features with Clinical Parameters 中文标题：基于多组学的肾结石形成预测模型：整合肠道微生物和代谢特征与临床参数讲者：Dang Kai教授单位：首都医科大学附属北京友谊医院摘要号：P0307 英文标题： Associations of estimated glucose disposal rate with kidney stones： results from two prospective cohorts 中文标题：估算葡萄糖清除率与肾结石的相关性：两项前瞻性队列研究的结果讲者：Wang Jialong教授单位：扬州大学附属医院摘要号：P0308 英文标题：Development and Validation of a Predictive Model for Kidney Stone Recurrence：Integrating Gut Multi-Omics and Clinical Pro les 中文标题：肾结石复发预测模型的开发与验证：整合肠道多组学和临床特征讲者：Dang Kai教授单位：首都医科大学附属北京友谊医院摘要号：P0337 英文标题：Analysis of the Association of Pediatric Urinary Stone Composition with Clinical Features and Laboratory Indicators：A 15-Year, Single-Center, Propensity Score Matched Retrospective Study 中文标题：儿童泌尿系结石成分与临床特征和实验室指标相关性分析：一项为期15年的单中心倾向评分匹配回顾性研究讲者：Yuan Chi教授单位：四川大学华西医院摘要号：P0427 英文标题：Serum cystatin C and globulin as independent risk factors for recurrence of calcium oxalate stones：A retrospective cohort study 中文标题：血清胱抑素C和球蛋白作为草酸钙结石复发的独立危险因素：一项回顾性队列研究讲者：Xia Kaiguo教授单位：安徽医科大学第一附属医院摘要号：P0434 英文标题：Clinical characteristics and significance of urinary crystals in patients with calculi 中文标题：尿结晶在结石患者中的临床特征和意义讲者：Jiang Hongtao教授单位：深圳市人民医院摘要号：P0757 英文标题：Bidirectional association between hypertension and the risk of kidney stones disease： A prospective study based on the UK Biobank 中文标题：高血压与肾结石风险的双向关联：一项基于英国生物银行的前瞻性研究讲者：Cong Han教授单位：中山大学附属第八医院摘要号：P0761 英文标题：High-Fat Diet Exacerbates Renal Crystal Deposition via a Gut-Kidney Axis Mechanism 中文标题：高脂饮食通过肠-肾轴机制加剧肾脏晶体沉积讲者：Hong Sen-Yuan教授单位：华中科技大学同济医学院附属同济医院摘要号：P0762 英文标题：Dietary protein intake and kidney stone risk： new evidence from a large population based study 中文标题：膳食蛋白质摄入量与肾结石风险：一项基于大型人群研究的新证据讲者：Wang Menghua教授单位：四川大学华西医院摘要号：P0763 英文标题：Differential associations and mechanistic evidence of dietary sweeteners on kidney stones： integrating the UK Biobank prospective cohort study and a translational animal study 中文标题：膳食甜味剂与肾结石的差异性关联及机制证据：整合英国生物银行前瞻性队列研究和转化动物研究讲者：He Zhaohui教授单位：中山大学附属第八医院摘要号：P0764 英文标题：Bidirectional Association between Hypertension and the Risk of Kidney Stones： Association between special diets and the risk of kidney stones disease： A prospective study based on the UK Biobank 中文标题：高血压与肾结石风险的双向关联：特殊饮食与肾结石疾病风险之间的关联：一项基于英国生物银行的前瞻性研究讲者：Cong Han教授单位：中山大学附属第八医院摘要号：P0767 英文标题：High-risk Pathogens and Factors to Postoperative Infection after Upper Urinary Tract Calculi Surgery： A Retrospective Analysis of 4,018 Patients 中文标题：上尿路结石手术后感染的高危病原体和相关因素：一项对4018例患者的回顾性分析讲者：Ye Lie-Fu教授单位：福州大学附属省立医院摘要号：P0769 英文标题：MATCH Score： A Predictive Model for Intraoperative Conversion During Ureteroscopic Laser Lithotripsy for Impacted Ureteral Stones 中文标题：MATCH评分：输尿管镜激光碎石术治疗嵌顿性输尿管结石术中转开腹手术的预测模型讲者：Wang Yanbo教授单位：吉林大学第一医院摘要号：P0884 英文标题： A Novel CT–Ultrasound Fusion Navigation System Enhances Precision and Safety of Percutaneous Nephrolithotomy： Results from a Multicenter Randomized Tria 中文标题：一种新型CT-超声融合导航系统提高了经皮肾镜取石术的精准性和安全性：一项多中心随机试验的结果讲者：Cheng Fan教授单位：武汉大学人民医院其他摘要号：P0019 英文标题： Innovative Noninvasive Assessment of Erectile Function in Mice： A Methodological Study Integrating Optogenetics and Chemogenetics 中文标题：小鼠勃起功能创新性无创评估：一项整合光遗传学和化学遗传学的方法学研究讲者：Hu Peng教授单位：华中科技大学同济医学院附属同济医院摘要号：P0021 英文标题：Extracellular matrix remodeling mediates cavernosal fibroblast senescence and erectile dysfunction under diabetic conditions 中文标题：糖尿病状态下，细胞外基质重塑介导海绵体成纤维细胞衰老和勃起功能障碍讲者：Han Zhitao教授单位：中山大学附属第五医院摘要号：P0022 英文标题： Exosomes delivering CRISPRi technology ameliorate erectile dysfunction by targeting PDE5 and JAK2 in diabetic ED rats 中文标题：外泌体递送CRISPR技术通过靶向PDE5和JAK2改善糖尿病勃起功能障碍大鼠的勃起功能障碍讲者：Sun Taotao教授单位：郑州大学第一附属医院摘要号：P0059 英文标题： Mesenchymal stem cells-derived biomimetic hydrogels integrate the repair of the urethra 中文标题：间充质干细胞衍生的仿生水凝胶整合了尿道修复讲者：Jiang Yaohui教授单位：浙江省人民医院摘要号：P0060 英文标题： Integrative multi-omics analysis reveals THBS1-positive broblasts as therapeutic targets to inhibit ureteral brosis progression after thermal injury 中文标题：整合多组学分析揭示，THBS1阳性成纤维细胞是抑制热损伤后输尿管纤维化进展的治疗靶点讲者：Fangzhou Zhao教授单位：北京大学第一医院摘要号：P0069 英文标题：The injectable gelatin-sodium alginate drug delivery systems for urethral stricture disease through the enhancement of tissue repair and prevention of broblast driven extracellular matrix remodeling 中文标题：通过增强组织修复和预防成纤维细胞驱动的细胞外基质重塑，用于治疗尿道狭窄疾病的可注射明胶-海藻酸钠药物递送系统讲者：Zhu Zhen Peng教授单位：北京大学第一医院摘要号：P0091 英文标题：3D bioprinting of tissue engineered bladder patches containing a neural-vascular network using conductive microgels 中文标题：利用导电微凝胶进行含有神经血管网络的组织工程膀胱贴片的3D生物打印讲者：An Ziyan教授单位：中国人民解放军总医院摘要号：P0096 英文标题：Wireless on-demand electrostimulation implants enable sphincter neuromuscular restoration from mixed urinary incontinence 中文标题：无线按需电刺激植入物能够帮助混合性尿失禁患者恢复括约肌神经肌肉功能讲者：Shao Yuan教授单位：上海交通大学医学院附属瑞金医院摘要号：P0100 英文标题：Is cognitive decline associated with overactive bladder syndrome and medication use? 中文标题：认知能力下降与膀胱过度活动症和药物使用有关吗？讲者：Jiang Yaohui教授单位：四川大学华西医院摘要号：P0106 英文标题：Efficacy of Combined Inferior Hypogastric Plexus and Pudendal Nerve Elongated Needle Electrical Stimulation for Chronic Refractory Pelvic and Perineal Pain： A Pilot Study 中文标题：联合应用下腹下神经丛和阴部神经长针电刺激治疗慢性难治性盆腔和会阴疼痛的疗效：一项初步研究讲者：Lyu Rong教授单位：上海浦东新区公利医院摘要号：P0108 英文标题：Interstitial cystitis/bladder pain syndrome Increases Alzheimer's Disease Risk： Mendelian Randomization-Based Causal Evidence and Comorbidity Gene-Driven Machine Learning Diagnostic Model 中文标题：间质性膀胱炎/膀胱疼痛综合征增加阿尔茨海默病风险：基于孟德尔随机化的因果证据和共病基因驱动的机器学习诊断模型讲者：Liu B.教授单位：中山大学第三附属医院摘要号：P0127 英文标题：A Multicenter Randomized Controlled Trial Protocol： Evaluating Transpelvic Magnetic Stimulation Combined with Biofeedback for Chronic Prostatitis/Chronic Pelvic Pain Syndrome 中文标题：一项多中心随机对照试验方案：评估经盆腔磁刺激联合生物反馈治疗慢性前列腺炎/慢性盆腔疼痛综合征的疗效讲者：Tao Xu教授单位：西安交通大学摘要号：P0276 英文标题：Sexual Function Outcomes After Modi ed Posterior Colporrhaphy Versus Traditional Vaginoplasty for Vaginal Laxity： A Comparative Study with over 2 Years of Follow-up 中文标题：改良后阴道壁修补术与传统阴道成形术治疗阴道松弛后性功能结果的比较研究：一项超过2年随访的对比研究讲者：Shen Sihong教授单位：四川大学华西医院摘要号：P0284 英文标题：A Piezocatalytic Hydrogel Dressing for In-Situ Gas Therapy of Urinary Incontinence Complications 中文标题：一种用于尿失禁并发症原位气体治疗的压电催化水凝胶敷料讲者：Wang Jiawen教授单位：福建省立医院摘要号：P0285 英文标题：Efficacy of Repetitive Transcranial Magnetic Stimulation (rTMS) in Treating Overactive Bladder：A Prospective Mechanistic Study Integrating Advanced Neuroimaging and Clinical Assessments 中文标题：重复经颅磁刺激（rTMS）治疗膀胱过度活动症的疗效：一项整合先进神经影像学和临床评估的前瞻性机制研究讲者：Yang Xunguo教授单位：南方医科大学南方医院摘要号：P0286 英文标题：Cumulative Social Disadvantage and Risk of Overactive Bladder： A National Cross Sectional Study with Machine Learning and Mediation Analysis 中文标题：累积性社会劣势与膀胱过度活动症风险：一项基于机器学习和中介分析的全国横断面研究讲者：Lin Weilong教授单位：中山大学孙逸仙纪念医院摘要号：P0309 英文标题：C1q+ Macrophages Drive CD8+ T Cell Exhaustion via the Cr1l/NF-κB/Tox Axis to Promote Kidney Allotransplant Tolerance 中文标题：C1q+巨噬细胞通过Cr1l/NF-κB/Tox轴驱动CD8+T细胞耗竭，从而促进肾脏同种异体移植耐受性讲者：Ge Jifu教授单位：上海交通大学医学院附属第一人民医院摘要号：P0311 英文标题：Gut microbe-derived ursodeoxycholic acid promotes fatty acid oxidation to protect against renal ischemia-reperfusion injury 中文标题：肠道微生物来源的熊去氧胆酸促进脂肪酸氧化，从而保护肾脏免受缺血再灌注损伤讲者：Xie M.教授单位：南方医科大学南方医院摘要号：P0313 英文标题：Distinct Clinicopathological Aggressiveness of Upper Tract Urothelial Carcinoma Compared to Bladder Cancer in Renal Transplant Recipients： A Case-Control Study 中文标题：肾移植受者上尿路尿路上皮癌与膀胱癌的临床病理侵袭性差异：一项病例对照研究讲者：Li Xiaoyu教授单位：北京大学第一医院摘要号：P0326 英文标题：A deep learning-based model for multiphase CT image segmentation and single kidney renal function estimation： A multi-disease multicenter retrospective cohort study 中文标题：基于深度学习的多期CT图像分割和单肾肾功能评估模型：一项多疾病多中心回顾性队列研究讲者：Bao Liuru教授单位：广东省人民医院摘要号：P0331 英文标题：Integrated Histology and Transcriptomics Identify Novel Fibrotic Targets in Hypospadias 中文标题：整合组织学和转录组学分析揭示尿道下裂中新的纤维化靶点讲者：Yu Mingming教授单位：上海市儿童医院摘要号：P0352 英文标题：The Impact of Neoadjuvant Therapy on Early Postoperative Continence Recovery after Radical Prostatectomy 中文标题：新辅助治疗对根治性前列腺切除术后早期尿控恢复的影响讲者：Chen S.教授单位：四川大学华西医院摘要号：P0399 英文标题：Male Infertility： Global Burden and Spatiotemporal Trends from 1990–2021 and Projected Trajectories to 2050 中文标题：男性不育症：1990-2021年全球负担和时空趋势以及至2050年的预测轨迹讲者：Zhou Xianghong教授单位：四川大学华西医院摘要号：P0405 英文标题：Microsurgical Varicocelectomy Reverses the Abnormality of Seminal Microbiome in Patients with Varicocele 中文标题：显微外科精索静脉曲张切除术可逆转精索静脉曲张患者精液微生物群的异常讲者：Xi Wei教授单位：复旦大学附属中山医院摘要号：P0406 英文标题： Coenzyme Q2 Enhances Heat Stress-Induced Anti-Proliferative and Pro-Apoptotic Effects via AMPK Pathway Inactivation in Mouse Testicular Cell Lines 中文标题：辅酶Q2通过AMPK通路失活增强热应激诱导的小鼠睾丸细胞系抗增殖和促凋亡作用讲者：Wu Yupeng教授单位：南方医科大学第三附属医院摘要号：P0407 英文标题：Therapeutic efficacy and mechanistic exploration of umbilical cord mesenchymal stem cell transplantation for non-obstructive azoospermia 中文标题：脐带间充质干细胞移植治疗非梗阻性无精子症的疗效及机制研究讲者：Zhu Shiqing教授单位：华中科技大学同济医学院附属同济医院摘要号：P0408 英文标题：Machine learning-based seminal plasma metabolomics for the diagnosis of non obstructive azoospermia and prediction of microTESE success rate 中文标题：基于机器学习的精浆代谢组学在非梗阻性无精子症诊断和显微睾丸取精术成功率预测中的应用讲者：Zhu Shiqing教授单位：华中科技大学同济医学院附属同济医院摘要号：P0409 英文标题：UV-aged PVC nanoplastics induce testicular toxicity in mice by disrupting WNT-mediated communication between Fos+ Leydig cells and spermatogonia 中文标题：紫外线老化的聚氯乙烯纳米塑料通过破坏Fos+ Leydig细胞和精原细胞之间WNT介导的通讯，诱导小鼠睾丸毒性讲者：Ran lingxiang教授单位：北京大学第一医院摘要号：P0410 英文标题：Biomimetic nanotechnology overcoming the Blood-Testis barrier for testicular protection in chemotherapy 中文标题：仿生纳米技术克服血睾屏障，在化疗中保护睾丸讲者：Zhao Xiaozhi教授单位：南京鼓楼医院摘要号：P0416 英文标题：Single-cell landscape reveals Activin A-driven in ammatory and brotic mechanism in hypospermatogenesis-related non-obstructive azoospermia with cryptorchidism 中文标题：单细胞图谱揭示了激活素A驱动的促炎和促细胞生成机制在低精子发生相关非梗阻性无精子症伴隐睾症中的作用讲者：Zhu Shiqing教授单位：华中科技大学同济医学院附属同济医院摘要号：P0459 英文标题：Prediction of immune-related adverse events in urological cancer during checkpoint inhibitor immunotherapy through immunohistochemical analysis of tumorous LCP1/ADPGK 中文标题：通过肿瘤LCP1/ADPGK的免疫组织化学分析预测泌尿系统癌症患者在免疫检查点抑制剂免疫治疗期间发生的免疫相关不良事件讲者：Xu Liqing教授单位：北京大学第一医院摘要号：P0490 英文标题： Optimal sexual frequency may exist and help mitigate depression odds in young and middle-aged U.S. citizens： A cross-sectional study 中文标题：一项横断面研究表明，最佳性生活频率可能存在，并有助于降低美国青年和中年公民的抑郁症风险讲者：zhang zhongfu教授单位：深圳市第二人民医院摘要号：P0505 英文标题：Fractional CO₂ Laser versus Biofeedback Therapy in Mild to Moderate Female Stress Urinary Incontinence： A Prospective Randomized Controlled Trial 中文标题：二氧化碳点阵激光与生物反馈疗法治疗轻中度女性压力性尿失禁的疗效比较：一项前瞻性随机对照试验讲者：Ke Junzhe教授单位：中山大学附属第三医院摘要号：P0511 英文标题：Trends in Urinary Incontinence among U.S. Women with Overweight/Obesity： A Pre and Post-Pandemic Analysis (2017-2023) 中文标题：美国超重/肥胖女性尿失禁趋势：疫情前后分析（2017-2023年）讲者：Liu Bolong教授单位：中山大学附属第三医院摘要号：P0517 英文标题：Impact of pyrethroid metabolite exposure on male stress urinary incontinence： Epidemiological evidence and mechanistic insights 中文标题：拟除虫菊酯代谢物暴露对男性压力性尿失禁的影响：流行病学证据和机制研究讲者：Xia Xiaozhi教授单位：四川大学华西医院摘要号：P0545 英文标题：Predictive Value of Immunohistochemistry-Based Molecular Subtyping for Neoadjuvant Therapy Sensitivity 中文标题：免疫组织化学分子分型对新辅助治疗敏感性的预测价值讲者：Yang Xiao教授单位：南京医科大学附属第一医院摘要号：P0593 英文标题：Development and validation of the fourth-generation participatory assessment tool for patients with neurogenic bladder 中文标题：开发和验证第四代神经源性膀胱患者参与式评估工具讲者：Cheng Wenyu教授单位：山西医科大学第一医院摘要号：P0595 英文标题：miR-21-5p regulates macrophage M2 polarization and mediates bladder brosis after spinal cord injury 中文标题：miR-21-5p调控巨噬细胞M2极化并介导脊髓损伤后的膀胱纤维化讲者：Ruan Jimeng教授单位：首都医科大学宣武医院摘要号：P0599 英文标题：The Impact of Dynamic Depression Trajectories on Incident Urination and Defecation Disorders：A Nationwide Cohort Study 中文标题：动态抑郁症发展轨迹对新发排尿和排便障碍的影响：一项全国性队列研究讲者：Zihao Li教授单位：西北医院摘要号：P0601 英文标题：Impact of continuous bladder drainage on bladder function in patients with detrusor underactivity：A urodynamic-based retrospective study 中文标题：持续膀胱引流对逼尿肌功能减退患者膀胱功能的影响：一项基于尿动力学的回顾性研究讲者：Yao Kaifeng教授单位：北京大学第一医院摘要号：P0607 英文标题：High Fat Diet Exacerbates Long-Term Air Pollutants Exposure Associated Benign prostatic hyperplasia：Large-scale Prospective Population Evidences 中文标题：高脂肪饮食加剧长期空气污染物暴露相关的良性前列腺增生：大规模前瞻性人群证据讲者：Wei Chuzhong教授单位：四川大学华西医院摘要号：P0608 英文标题：Combined Prostate Columnar Water-Balloon Dilation and Bladder Hydrodistention for the Treatment of Interstitial Cystitis in Male Patients 中文标题：前列腺柱状水球扩张联合膀胱水扩张术治疗男性间质性膀胱炎讲者：Huang Banggao教授单位：浙江省人民医院摘要号：P0665 英文标题：Local hydrogel delivery of anti fibrotic agents blocks DDX3X-NLRP3 inflammasome activation and reduces wound brosis after BPH surgery 中文标题：局部水凝胶递送抗纤维化药物可阻断DDX3X-NLRP3炎症小体激活，并减少良性前列腺增生手术后的伤口纤维化讲者：Chenghao Zheng教授单位：上海交通大学医学院附属第一人民医院摘要号：P0666 英文标题：Hormonal imbalance–induced CNR1 activation drives stromal brosis progression in benign prostatic hyperplasia via the Rap1 pathway 中文标题：激素失衡诱导的 CNR1 激活通过 Rap1 通路驱动良性前列腺增生中的基质纤维化进展讲者：Liu Zhanliang教授单位：首都医科大学附属北京友谊医院摘要号：P0667 英文标题：Mechanism of the Piezo1/Notch1/CTGF signaling axis mediating urothelial cell broblast crosstalk in bladder brosis after bladder outlet obstruction 中文标题：膀胱出口梗阻后膀胱纤维化中 Piezo1/Notch1/CTGF 信号轴介导尿路上皮细胞与成纤维细胞相互作用的机制讲者：Li Zhipeng教授单位：华中科技大学同济医学院附属同济医院摘要号：P0668 英文标题：LPCAT2-driven phosphatidylcholine metabolic dysregulation in broblasts promotes BPH progression 中文标题：LPCAT2驱动的成纤维细胞磷脂酰胆碱代谢紊乱促进良性前列腺增生症的进展讲者：Zeng Zhou教授单位：中山大学孙逸仙纪念医院摘要号：P0672 英文标题：Plasma Proteomic Pro ling Identi es TSPAN1 as a Key Predictor of Benign Prostatic Hyperplasia Risk in a Large Prospective Cohort 中文标题：血浆蛋白质组学分析发现TSPAN1是大型前瞻性队列研究中良性前列腺增生风险的关键预测因子讲者：Chen Yongming教授单位：北京医院摘要号：P0673 英文标题：Distinct SRD5A2-reduced Subtypes of Benign Prostatic Hyperplasia Exhibit pAMPK/Rab9a/PLIN3-Mediated Lipophagic Compensation for Androgen Signaling Defects 中文标题：良性前列腺增生症的不同SRD5A2减少亚型表现出pAMPK/Rab9a/PLIN3介导的脂质自噬补偿，以弥补雄激素信号缺陷讲者：Lin Zhemin教授单位：首都医科大学附属北京世纪坛医院摘要号：P0674 英文标题：Deciphering the Therapeutic Mechanisms of Resveratrol in Benign Prostatic Hyperplasia through Multi-Omics and Experimental Validation 中文标题：通过多组学和实验验证揭示白藜芦醇治疗良性前列腺增生的机制讲者：Jinze Li教授单位：成都中医药大学附属德阳市人民医院摘要号：P0675 英文标题：TRMT61A-mediated tRNA m1A modi cation promotes benign prostatic hyperplasia via e cient Hippo pathway translation 中文标题：TRMT61A介导的tRNA m1A修饰通过高效的Hippo通路翻译促进良性前列腺增生讲者：Liu Y.教授单位：深圳第二人民医院摘要号：P0725 英文标题：Long-Term Trajectories of Metabolic and In ammatory Biomarkers and the Risk of Incident Benign Prostatic Hyperplasia： A 13-Year Longitudinal Study in a Large Scale Western China Cohort 中文标题：代谢和炎症生物标志物的长期变化轨迹与良性前列腺增生症发生风险：一项来自中国西部大型队列的13年纵向研究讲者：Lyu Xinyi教授单位：四川大学华西医院摘要号：P0730 英文标题：Construction of Anatomical Risk Map for Post-HoLEP Stress Urinary Incontinence Based on MRI 中文标题：基于磁共振成像的HoLEP术后压力性尿失禁解剖风险图构建讲者：Kong Jianqiu教授单位：孙逸仙纪念医院摘要号：P0737 英文标题：Cell crosstalk in a mouse chronic cystitis model disrupts epithelial differentiation and reshapes the urothelium 中文标题：在小鼠慢性膀胱炎模型中，细胞间相互作用会破坏上皮细胞分化并重塑尿路上皮讲者：Dai Yi教授单位：四川大学华西第四医院摘要号：P0738 英文标题： Investigating the role of pituitary adenylate cyclase–activating polypeptide (PACAP) in the pathogenesis and treatment of Hunner-type interstitial cystitis 中文标题：探讨垂体腺苷酸环化酶激活肽（PACAP）在Hunner型间质性膀胱炎的发病机制和治疗中的作用讲者：Ke Hanwei教授单位：四川大学华西医院摘要号：P0739 英文标题："From Urine, For the Bladder"： Intravesical Delivery of Urine-Derived Stem Cell Extracellular Vesicles via Adhesive Microspheres for Treating Bladder In ammation 中文标题：“源自尿液，造福膀胱”：利用粘附微球将尿源性干细胞胞外囊泡膀胱内递送至膀胱治疗膀胱炎症讲者：Xu Xueyuan教授单位：四川大学华西医院摘要号：P0740 英文标题：Hyaluronic acid-based composite nanoparticles promote urothelium repair in interstitial cystitis/ bladder pain syndrome 中文标题：基于透明质酸的复合纳米颗粒可促进间质性膀胱炎/膀胱疼痛综合征的尿路上皮修复讲者：Liu Mengzhu教授单位：首都医科大学附属北京友谊医院摘要号：P0741 英文标题：Differences in Functional Brain Regions in Patients with Interstitial Cystitis/Painful Bladder Syndrome： A Resting-State Functional Magnetic Resonance Imaging Study 中文标题：间质性膀胱炎/膀胱疼痛综合征患者功能性脑区差异：一项静息态功能磁共振成像研究讲者：Meng Lingfeng教授单位：北京医院摘要号：P0743 英文标题：Antler Stem Cell Exosomes Ameliorate Interstitial Cystitis via Mitochondrial Component Transfer to Reprogramming Macrophage Polarization 中文标题：鹿茸干细胞外泌体通过线粒体成分转移至巨噬细胞极化重编程，从而改善间质性膀胱炎讲者：Wan Yicheng教授单位：中山大学附属第三医院摘要号：P0746 英文标题：Mechano-metabolic crosstalk orchestrates bladder brotic remodeling in bladder underactivity 中文标题：机械代谢相互作用协调膀胱活动不足时的膀胱纤维化重塑讲者：Jiawei Chen教授单位：四川大学华西医院摘要号：P0748 英文标题：Mechanism of hydroxyapatite/hyaluronic acid composite hydrogel in promoting urethral repair in stress urinary incontinence 中文标题：羟基磷灰石/透明质酸复合水凝胶促进压力性尿失禁尿道修复的机制讲者：Liu Mengzhu教授单位：首都医科大学附属北京友谊医院摘要号：P0806 英文标题：Single Intraoperative Triamcinolone Injection Prevents Recurrent Bladder Neck Contracture After BPH Surgery 中文标题：单次术中注射曲安奈德可预防良性前列腺增生术后膀胱颈挛缩复发讲者：Liu Ben教授单位：浙江大学医学院附属第一医院摘要号：P0815 英文标题：Targeting Leydig cells to promote autophagy-mediated cholesterol uptake ameliorates age-related testicular lipid metabolic disorders 中文标题：靶向睾丸间质细胞以促进自噬介导的胆固醇摄取可改善与年龄相关的睾丸脂质代谢紊乱讲者：Ningjing Ou教授单位：中山大学附属第五医院摘要号：P0824 英文标题：Association Between Dietary Viable Microorganism Intake and the Risk of Testosterone Deficiency in Men 中文标题：膳食中活性微生物摄入量与男性睾酮缺乏风险之间的关联讲者：Xingliang Feng教授单位：苏州大学附属第三医院摘要号：P0899 英文标题：Patient-derived Immunocompetent Tumor Organoids Reveal Immunostimulatory Effects of Microbial Therapy 中文标题：患者来源的免疫活性肿瘤类器官揭示了微生物疗法的免疫刺激作用讲者：Zihan Zhao教授单位：南京鼓楼医院摘要号：P0900 英文标题：SLAMF9+ TAM aggravates CD8+ T cell non-response to immune checkpoint blockade via SLAMF9/CD137 interaction 中文标题：SLAMF9+ TAM 通过 SLAMF9/CD137 相互作用加剧CD8+ T细胞对免疫检查点阻断的无反应讲者：Chen Changhao教授单位：中山大学孙逸仙纪念医院摘要号：P0953 英文标题：Comparative performance of CXCR4-directed PET/CT and adrenal venous sampling for subtype classi cation and outcome prediction in primary aldosteronism 中文标题：CXCR4靶向PET/CT与肾上腺静脉取样在原发性醛固酮增多症亚型分类和预后预测中的比较性能讲者：董强教授单位：四川大学华西医院摘要号：P0981 英文标题：Treatment of interstitial cystitis with bladder perfusion of recombinant human collagen type 3 中文标题：采用重组人胶原蛋白3型膀胱灌注治疗间质性膀胱炎讲者：Xiaokai Shi教授单位：南京医科大学第三医院摘要号：P1002 英文标题：Multimodal deep learning model for AI-based functional prognostic risk stratification in patients undergoing radical nephrectomy 中文标题：基于人工智能的多模态深度学习模型用于根治性肾切除术患者的功能性预后风险分层讲者：Luo Yunhan教授单位：中山大学肿瘤防治中心摘要号：P1003 英文标题：Turning the Tide of Scarring： A Supramolecular Hydrogel Delivering BMSCs to Rebuild the Urethra. 中文标题：扭转瘢痕形成：一种输送骨髓间充质干细胞以重建尿道的超分子水凝胶讲者：She Linlu教授单位：中山大学第五医院摘要号：P1013 英文标题：Pre-freezing stimulation mitigates ureteral injury and subsequent obstruction in novel rabbit models for endogenous thermal exposures 中文标题：在新型兔内源性热暴露模型中，冷冻前刺激可减轻输尿管损伤和随后的梗阻讲者：Song Qingtian教授单位：中南大学湘雅医院摘要号：P1017 英文标题：Lingual mucosal graft ureteroplasty combined with ureteral reimplantation or boari ap ureteroneocystostomy for one-stage repair of long and multifocal ureteral strictures： Technique Description and the Medium-term Outcome 中文标题：舌黏膜移植输尿管成形术联合输尿管再植术或Boari ap输尿管膀胱吻合术一期修复长段多灶性输尿管狭窄：技术描述及中期疗效讲者：Li Bing教授单位：武汉大学中南医院摘要号：P1018 英文标题：Posteriorly Augmented Anastomotic Ureteroplasty with Lingual Mucosal onlay Grafts： 8-Year Multi-institutional Experience in 61 Cases 中文标题：采用舌黏膜移植片进行后路扩大吻合式输尿管成形术：61例病例的8年多中心经验讲者：Li Bing教授单位：武汉大学中南医院整理自EAU官网（来源：《肿瘤瞭望-泌尿时讯》编辑部）声明凡署名原创的文章版权属《肿瘤瞭望》所有，欢迎分享、转载。本文仅供医疗卫生专业人士了解最新医药资讯参考使用，不代表本平台观点。该等信息不能以任何方式取代专业的医疗指导，也不应被视为诊疗建议，如果该信息被用于资讯以外的目的，本站及作者不承担相关责任。

临床研究

2026-02-10

·drugs

Coffee And Tea Help Protect Brain Health

TUESDAY, Feb. 10, 2026 — A few cups of coffee or tea each day can help your brain age more gracefully, a new study says. About two to three cups of caffeinated joe — or one to two cups of tea — reduced dementia risk and slowed brain aging, researchers reported Feb. 9 in the Journal of the American Medical Association . However, don’t count on your morning coffee alone to preserve your brain health, researchers warned. “While our results are encouraging, it’s important to remember that the effect size is small and there are lots of important ways to protect cognitive function as we age,” senior researcher Dr. Daniel Wang , an associate scientist at Mass General Brigham in Boston, said in a news release. “Our study suggests that caffeinated coffee or tea consumption can be one piece of that puzzle,” Wang added. Coffee and tea contain ingredients like caffeine that have emerged as potential factors in brain health, protecting it by reducing inflammation and cellular damage, researchers said in background notes. To see whether these drinks actually help, researchers analyzed data from two major studies involving nearly 132,000 people. The studies tracked participants’ brain health and their consumption of either coffee or tea over a median 37 years, meaning half were followed longer, half for a shorter time. People with the highest intake of caffeinated coffee had an 18% lower risk of dementia, researchers found. They also had less brain decline as found in cognitive testing — about 7.8% versus 9.5% for those who drank little to no coffee. Similar results were found in caffeinated tea, but not decaf coffee, suggesting that caffeine might be behind these brain benefits, researchers said. Benefits were most pronounced in people who drank two to three cups of coffee or one to two cups of tea every day, the study found. But even higher caffeine intake didn’t cause any negative effects, instead providing similar brain benefits as those found in a few cups of coffee, researchers said. “We also compared people with different genetic predispositions to developing dementia and saw the same results — meaning coffee or caffeine is likely equally beneficial for people with high and low genetic risk of developing dementia,” lead researcher Dr. Yu Zhang , a doctoral student at the Harvard TH Chan School of Public Health, said in a news release. Sources Mass General Brigham, news release, Feb. 9, 2026

100 项与枸橼酸咖啡因相关的药物交易

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KEGG	Wiki	ATC	Drug Bank
D07603	枸橼酸咖啡因	N06BC01	DB00201

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适应症	国家/地区	公司	日期
新生儿呼吸暂停	加拿大	CHIESI Farmaceutici SpA	2020-03-04
呼吸暂停	美国	Hikma Pharmaceuticals USA, Inc.	1999-09-21

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适应症	最高研发状态	国家/地区	公司	日期
神经肌肉阻滞逆转	临床1期	美国	The University of Chicago	2023-05-01

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT07076654 (Pubmed \| J Anesth Analg Crit Care)	N/A	低血压	90	200 mg oral caffeine	獵積壓襯簾衊選齋鏇繭(願築糧製鑰窪淵繭蓋壓) = 糧鹽範網壓艱鹹廠繭構繭齋淵鹽積遞簾襯窪製 (餘壓遞鏇廠製憲願鬱齋 ) 更多	积极	2026-01-15
				Placebo	獵積壓襯簾衊選齋鏇繭(願築糧製鑰窪淵繭蓋壓) = 鹹觸繭襯積鹹鹽鏇鏇積繭齋淵鹽積遞簾襯窪製 (餘壓遞鏇廠製憲願鬱齋 ) 更多
NCT05741385 (CTgov)	N/A	纤维化 \| 肝硬化	4	warfarin sodium+warfarin+omeprazole+metoprolol+midazolam+caffeine	鹽鑰蓋糧窪衊淵構顧觸(衊醖選鑰範觸蓋網簾壓) = 鑰艱醖製艱襯壓廠願艱淵積觸餘糧衊鑰蓋遞艱 (願壓齋蓋鹹鹹積衊構廠, 37.3) 更多	-	2025-09-10
NCT06195137 (Pubmed \| J Oral Rehabil)	N/A	口灼伤综合征	118	Caffeine 120-150 mg	願窪觸鏇廠鬱憲願憲築(鏇網餘鑰壓鏇顧憲選構) = 鬱壓簾壓淵鏇簾衊繭壓廠壓鏇糧構齋鏇淵鬱齋 (觸願鬱壓遞鏇夢簾壓衊 )	积极	2025-07-01
				Alpha-Lipoic Acid 200 mg	願窪觸鏇廠鬱憲願憲築(鏇網餘鑰壓鏇顧憲選構) = 廠壓鏇壓醖衊鑰淵壓願廠壓鏇糧構齋鏇淵鬱齋 (觸願鬱壓遞鏇夢簾壓衊 )
NCT04950660 (CTgov)	临床4期	雄激素不敏感综合征 \| 疼痛 \| 特发性脊柱侧弯	61	Caffeine Tablet (Caffeine Arm)	壓膚餘鑰製醖範築鏇觸(簾蓋襯鏇範醖醖艱醖醖) = 艱築鑰壓窪鹹獵製繭衊餘簾憲鑰願築廠繭構艱 (醖鏇網簾願艱獵願範夢, 0.41) 更多	-	2025-02-21
				Placebo+Caffeine Tablet (Placebo Arm)	壓膚餘鑰製醖範築鏇觸(簾蓋襯鏇範醖醖艱醖醖) = 淵窪願鏇繭繭網積範觸餘簾憲鑰願築廠繭構艱 (醖鏇網簾願艱獵願範夢, 0.33) 更多
NCT03913221 (CTgov)	临床1期	缺氧缺血性脑病	17	Caffeine Citrate 5 mg/kg (Low Dose Caffeine (5 mg/kg))	簾窪齋顧鏇夢膚製襯衊(糧觸衊鹹膚壓構願選艱) = 構淵窪獵築顧網蓋繭鹹製淵餘製繭選鬱築壓選 (壓醖願夢鏇顧鏇鏇廠膚, 324.96) 更多	-	2024-09-19
				Caffeine Citrate 10 mg/kg (High Dose Caffeine (10 mg/kg))	簾窪齋顧鏇夢膚製襯衊(糧觸衊鹹膚壓構願選艱) = 衊夢範構蓋膚艱鬱醖顧製淵餘製繭選鬱築壓選 (壓醖願夢鏇顧鏇鏇廠膚, 134.42) 更多
NCT03340727 (MoCHA, CTgov)	临床3期	呼吸暂停	827	Placebo	簾淵簾餘顧夢願窪構願(窪糧鑰蓋窪製簾淵簾艱) = 憲糧願衊餘鬱憲襯廠壓構鹽艱齋遞鹽鹽夢顧襯 (鹹憲顧衊齋壓襯選選範, 鬱衊醖淵構觸艱鬱願廠 ~ 願餘遞製餘築艱顧繭餘) 更多	-	2024-06-28
NCT05919732 (CTgov)	临床4期	腹股沟疝	20	Dexmedetomidine+Tylenol+Bupivacaine+Caffeine (Caudal Infusion)	襯夢鹹醖醖壓夢顧蓋網 = 網鑰醖構積繭窪窪遞鬱襯網積窪蓋範選積淵糧 (廠鏇衊夢鬱鹽餘廠窪鑰, 醖憲蓋餘觸衊齋簾艱鏇 ~ 觸鹹鏇鏇獵鹹夢簾衊築) 更多	-	2024-04-02
				Tylenol+Propofol+caffeine+bupivacaine+rocuronium (General Anesthesia)	襯夢鹹醖醖壓夢顧蓋網 = 衊鑰選衊餘鬱餘窪範願襯網積窪蓋範選積淵糧 (廠鏇衊夢鬱鹽餘廠窪鑰, 網觸襯鑰觸遞廠鹽築積 ~ 鹹簾鹽齋蓋憲膚廠窪餘) 更多
NCT02323698 (CTgov)	临床1/2期	脊髓损伤 \| 缺氧	36	AIH+Caffeine (Caffeine/AIH)	築遞鏇蓋醖衊築遞遞鹽(鹹鏇齋顧製餘醖選簾願) = 夢網壓醖網構繭鑰鏇齋積獵衊衊襯積窪艱鑰齋 (獵觸觸窪艱簾廠積積蓋, 2.2) 更多	-	2022-08-09
				Placebo (Placebo/AIH)	築遞鏇蓋醖衊築遞遞鹽(鹹鏇齋顧製餘醖選簾願) = 範鹽鏇範繭醖壓築顧糧積獵衊衊襯積窪艱鑰齋 (獵觸觸窪艱簾廠積積蓋, 2.2) 更多
NCT03577730 (CTgov)	早期临床1期	术后疼痛	71	Caffeine Citrate (Experimental)	憲淵壓範繭顧淵膚構廠(艱廠範鏇繭淵遞構構築) = 獵餘醖壓網糧艱蓋淵簾鏇淵鏇鏇觸簾艱獵艱壓 (範鹽襯製獵醖糧築膚製, 鏇鏇壓醖襯衊築糧憲壓 ~ 繭獵顧鏇蓋鹹願願糧鑰) 更多	-	2021-10-06
				Dextrose Water (Control)	憲淵壓範繭顧淵膚構廠(艱廠範鏇繭淵遞構構築) = 壓憲窪鏇遞鹹鏇夢鏇糧鏇淵鏇鏇觸簾艱獵艱壓 (範鹽襯製獵醖糧築膚製, 製蓋築構網遞網構鏇餘 ~ 醖觸選鹹壓窪糧齋簾襯) 更多
NCT01629329 (Migraine, CTgov)	临床4期	急性偏头痛	93	Acetaminophen+Caffeine+Aspirin (Aspirin, Acetaminophen, Caffeine Pills)	選鏇範廠窪夢製築範築(夢鹽廠蓋顧餘觸齋構構) = 鑰選壓壓製淵鑰觸鏇鑰鏇範鹽願糧製夢構網鑰 (選襯糧網顧鏇範膚淵艱, 範夢餘糧齋願網範顧鬱 ~ 夢糧憲憲衊積觸膚鹹廠) 更多	-	2020-03-18
				Prochlorperazine (Prochlorperazine 10mg)	選鏇範廠窪夢製築範築(夢鹽廠蓋顧餘觸齋構構) = 築構夢餘獵製餘獵遞淵鏇範鹽願糧製夢構網鑰 (選襯糧網顧鏇範膚淵艱, 選窪鏇窪窪鏇構獵襯選 ~ 遞憲簾範築淵遞構願構) 更多