PLATIPUS is an adaptive platform trial aimed at improving the health of infants born preterm (before 37 weeks' gestation). PLATIPUS will compare how different treatments and care provided to pregnant women and people at risk of preterm birth and infants born preterm affect infant health.
The main questions PLATIPUS aims to answer are:
1. What effect/s do different treatments/care provided to pregnant women and people at risk of preterm birth have on the health of their infants? (Pregnancy domains)
2. What effect/s do different treatments/care given to infants born preterm have on their health ? (Neonatal domains).
This registration record relates to the PLATIPUS Core (or 'master') protocol which provides guidance for the overall running of the trial. Additional appendices will outline the aims, questions, treatments, and activities for each separate research question (domain). Each Domain-Specific Appendix will be registered separately on ClinicalTrials.gov and will link to this record.

开始日期2025-11-01

申办/合作机构

University of Melbourne

[+10]

NCT06972849

/ Not yet recruitingN/AIIT

BabyCCINO: Caffeine Citrate to Improve Neonatal Outcomes. A Neonatal Domain Within PLATIPUS.

The goal of this clinical trial to learn what dose/s of caffeine citrate works to treat preterm born babies who have episodes where they stop breathing. It will also learn about the safety of different doses of caffeine citrate for the variety of preterm-born babies that are prescribed this.
The main question it aims to answer is: Which dose is the optimal dose of caffeine citrate for very preterm babies to prevent short-term death and disease?
Researchers will compare three different doses of caffeine citrate, which are already used in clinical practice to treat breathing stoppages in preterm babies, to see which dose works best. No placebo will be used.
Participants will be given a 'loading' dose of caffeine citrate <72 hours of life, and a smaller 'maintenance' dose once a day, for as long as the baby needs this.
This trial will be undertaken as part of the PLATIPUS trial (NCT06461429).

开始日期2025-10-01

申办/合作机构

University of Melbourne

NCT06518603

/ Not yet recruiting临床4期IIT

Randomized Controlled Trial of Caffeine Citrate in Preterm Infants at Risk of Apnea in Zambia

The goal of this clinical trial is to learn if caffeine citrate prevents apneic events that result in sick visits in moderately preterm infants after discharge from the hospital. It will also learn if the use of caffeine leads to better developmental outcomes at 12 months of age.
Our research questions are:
1. Does continued treatment of moderately preterm newborns with caffeine citrate after hospital discharge prevent or decrease apneic events that result in sick visits?
2. Will the continued use of caffeine citrate lead to improved developmental outcomes among infants at 12 months of age?
Researchers will compare caffeine citrate to a placebo (a look-alike substance that contains no drug) to see if caffeine citrate prevents apneic spells which result in healthcare visits.
Parents of participants will:
1. Administer caffeine citrate 20mg/kg/day or a placebo (equivalent volume of sterile water) orally every day for up to 28 days after hospital discharge
2. Keep a diary of symptoms and any apneic events
3. Check in with researchers via telephone call once a week
4. Return to clinic for infant physical examination at 28 days
5. Return to the clinic for infant physical examination at 2 months
5. Return to clinic for infant neurodevelopmental examination with Ages and Stages Questionnaire at 12 months of age

开始日期2025-09-01

申办/合作机构

The University of Alabama at Birmingham

[+1]

100 项与枸橼酸咖啡因相关的临床结果

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100 项与枸橼酸咖啡因相关的转化医学

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100 项与枸橼酸咖啡因相关的专利（医药）

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31,676

项与枸橼酸咖啡因相关的文献（医药）

2025-12-31·Journal of the International Society of Sports Nutrition

Caffeine supplementation improved movement patterns and reactive agility in rugby sevens matches in male collegiate players

Article

作者: Hsueh, Chang-Li ; Sun, Cheng-Yen ; Chang, Chen-Kang

PURPOSE:

Rugby sevens is a high-intensity contact sport often played in two-day tournaments. Caffeine is widely used by rugby players for its performance-enhancing effects. This study aimed to investigate the impact of caffeine supplementation on various performance metrics, including distance covered at different speeds, acceleration, deceleration, collisions, and repeated high-intensity efforts across four matches over two consecutive days in collegiate male rugby sevens players. Reactive agility, a key performance attribute in rugby sevens, was also assessed before each match.

METHODS:

A position-matched, double-blind, randomized crossover design was employed, with six male collegiate rugby players (mean height: 1.78 ± 0.09 m, mean weight: 81.3 ± 9.2 kg, mean age: 21.5 ± 0.8 years) participating in two trials. Each trial consisted of a two-day tournament, with two matches per day. Performance was monitored using global positioning system units to track distance covered in various speed zones, as well as total distance, frequency of acceleration, deceleration, collisions, and repeated high-intensity efforts.

RESULTS:

The results indicated that in the placebo trial, participants covered significantly more distance at a walking pace (0-6 km/h) in match 4 compared to match 3 (match 3: 480.3 ± 32.7 m; match 4: 629.4 ± 21.3 m, p < 0.001, d = 0.117). In the caffeine trial, players covered significantly more distance at a jogging pace (6-12 km/h) in match 4 compared to the placebo trial (caffeine: 405.9 ± 9.8 m; placebo: 303.6 ± 20.2 m, p = 0.015, d = 1.693). Reactive agility was significantly better in the caffeine trial before match 3 (caffeine trial: 1.80 ± 0.17 s; placebo trial: 2.07 ± 0.18 s, p = 0.038, d = 0.858).

CONCLUSIONS:

Caffeine supplementation at 3 mg/kg may increase jogging and reduce walking and standing in the final match of a two-day rugby sevens tournament, while also improving reactive agility on the second day. This suggests that by mitigating fatigue in the later stages of the tournament, caffeine allowed players to shift from low-intensity activities to higher-intensity efforts. These adjustments may improve both offensive and defensive performance during rugby sevens matches. Therefore, rugby sevens players could benefit from taking caffeine supplements in the later stages of 2-day tournaments to optimize their performance.

2025-12-31·Journal of the International Society of Sports Nutrition

Effects of different dietary supplements on athletic performance in soccer players: a systematic review and network meta-analysis

Review

作者: Zhu, Xiaolin ; Nasharuddin, Nurul Amelina ; Xiang, Changqing ; Tengku Kamalden, Tengku Fadilah ; Luo, Hua

BACKGROUND:

As dietary supplements play a crucial role in meeting the unique nutritional needs of soccer players, a growing body of studies are exploring the effects of dietary supplements on athletic performance in soccer players. The effectiveness of certain supplements, such as caffeine and creatine, remains debated due to inconsistent results across studies. Therefore, this systematic review and Bayesian network meta-analysis was conducted to tentatively identify the most effective dietary supplements for soccer players.

METHODS:

We searched PubMed, Web of Science, Cochrane, Embase, and SPORTDiscus from database establishment to 5 February 2024 to identify randomized controlled trials (RCTs) evaluating the effects of different dietary supplements on athletic performance in soccer players. The risk of bias was assessed using the revised Cochrane risk-of-bias tool for randomized trials. A Bayesian network meta-analysis was performed using the R software and Stata 18.0. A subgroup analysis was conducted based on the competitive level of the athletes.

RESULTS:

Eighty RCTs were included, with 1,425 soccer players randomly receiving 31 different dietary supplements or placebo. The network meta-analysis showed that compared with placebo, carbohydrate + protein (SMD: 2.2, very large), carbohydrate + electrolyte (SMD: 1.3, large), bovine colostrum (SMD: moderate) and caffeine (SMD: 0.29, small) were associated with a significant effect on increasing the distance covered. Kaempferia parviflora (SMD: 0.46, small) was associated with a significant effect on enhancing muscular strength. Beta-alanine (SMD: 0.83, moderate), melatonin (SMD: 0.75, moderate), caffeine (SMD: 0.37, small), and creatine (SMD: 0.33, small) were associated with a significant effect on enhancing jump height. Magnesium creatine chelate (SMD: -3.0, very large), melatonin (SMD: -1.9, large), creatine + sodium bicarbonate (SMD: -1.4, large), and arginine (SMD: -1.2, moderate) were associated with a significant effect on decreasing sprint time. Creatine + sodium bicarbonate (SMD: -2.3, very large) and caffeine (SMD: -0.38, small) were associated with a significant effect on improving agility. Sodium pyruvate (SMD: 0.50, small) was associated with a significant effect on increasing peak power. Magnesium creatine chelate (SMD: 1.3, large) and sodium pyruvate (SMD: 0.56, small) were associated with a significant effect on increasing mean power. Carbohydrate + electrolyte (SMD: -0.56, small) was associated with a significant effect on improving the rating of perceived exertion.

CONCLUSIONS:

This study suggests that a range of dietary supplements, including caffeine, creatine, creatine + sodium bicarbonate, magnesium creatine chelate, carbohydrate + electrolyte, carbohydrate + protein, arginine, beta-alanine, bovine colostrum, Kaempferia parviflora, melatonin, and sodium pyruvate, can improve athletic performance in soccer players. This review provides evidence-based guidance for soccer coaches and nutritionists on using dietary supplements to enhance specific performance measures.

2025-12-31·Journal of the International Society of Sports Nutrition

Acute effects of isolated and combined dietary nitrate and caffeine ingestion on ergometer-based 1000 m time trial performance in highly trained kayakers

Article

作者: Bruhn, Sven ; Weippert, Matthias ; Mittlmeier, Thomas ; Behrens, Martin ; Pollex, Johannes

BACKGROUND:

Dietary nitrate (BR) and caffeine (CAF) ingestion have been shown to increase sports performance. However, the isolated and combined effects of BR and CAF ingestion on time trial (TT) performance as well as the accompanying physiological and perceptual responses have never been investigated in highly trained kayak athletes. Therefore, the present study examined the impact of an isolated and combined supplementation with BR (140 ml beetroot concentrate, ~12.5 mmol nitrate) and CAF (3 mg/kg bodyweight) on 1000 m ergometer TT performance as well as the accompanying physiological (i.e. cardiorespiratory function, muscle oxygenation, muscle activity) and perceptual responses (i.e. fatigue, effort, and exercise-induced pain perception) in male highly trained kayakers. It was hypothesized that the isolated ingestion of BR and CAF would both improve ergometer-based 1000 m TT performance and induce supplement-specific physiological and perceptual responses. Considering the primary effects of BR on muscle function and of CAF on the central nervous system, it was further assumed that the combined ingestion will result in an additional performance increase and supplement-specific physiological and perceptual responses.

METHODS:

Using a prospective, randomized, controlled, double-blind crossover design, 12 male highly trained kayak athletes from local clubs were investigated. They completed four measurement sessions resulting in four randomized conditions: (i) BR+CAF; (ii) BR+CAF placebo (BR+PLA); (iii) CAF+BR placebo (CAF+PLA); and (iv) BR placebo + CAF placebo (PLA+PLA). An air-braked instrumented kayak-ergometer was used to record 1000 m TT performance, power output, and stroke frequency. Heart rate (HR), oxygen uptake (VO₂), maximum VO₂ (VO_2max), respiratory equivalent of O₂ (VE/VO₂), and carbon dioxide (VE/VCO₂) were measured continuously. Furthermore, oxygenation of the deltoid muscle was measured with near-infrared spectroscopy (mNIRS) and muscle activity of nine unilateral muscles with surface electromyography (i.e. deltoideus, serratus anterior, triceps brachii caput lateralis, trapezius, infraspinatus, latissimus dorsi, obliquus externus, flexor carpi radialis, and vastus lateralis muscle) during the 1000 m TT. After the TT, fatigue, effort, and exercise-induced pain perception were queried. One- and two-way analysis of variance with repeated measures were conducted to determine differences between conditions for the entire 1000 m TT and predefined sections (0-50 m, 50-100 m, 100-150 m, 150-250 m, 250-500 m, 500-750 m, 750-1000 m), respectively (p ≤ 0.05).

RESULTS:

The supplements did not have an ergogenic effect on TT performance compared to the PLA+PLA condition, either in isolation or in combination. The same applied to the majority of physiological parameters and the perceptual responses. Nevertheless, VE/VO₂ was lower during the sections 150-250 m (-5.00%; p = 0.02) and 250-500 m (-3.49%; p = 0.03) in the BR+PLA condition, whereby VE/VCO₂ was higher during the section 150-250 m (4.19%; p = 0.04) in the CAF+PLA compared to the PLA+PLA condition, respectively.

CONCLUSIONS:

Data indicate that the isolated and combined ingestion of BR and CAF had no effect on 1000 m TT performance, the majority of physiological responses, and perceptual responses in highly trained kayakers. These findings might be related to the dosage and/or a ceiling effect due to the already efficient vascular, metabolic, and muscle function, including high amounts of endogenous produced nitric oxide, in athletes.

185

项与枸橼酸咖啡因相关的新闻（医药）

2025-07-08

·汇聚南药

咖啡抗癌再立功！南方医科大最新：咖啡因能激活T细胞，显著增强抗癌免疫反应

题图 | Unsplash撰文 | 宋文法结直肠癌（CRC），是全球第三大常见癌症，也是癌症相关死亡的第二大原因。尽管免疫疗法在癌症治疗中取得了显著进展，但在CRC患者中的应用有限，目前仅对错配修复缺陷或高微卫星不稳定性的CRC患者有效，而这类患者仅占CRC病例的15%。饮食习惯在癌症的发生和发展中起着关键作用，饮食干预可以通过限制肿瘤营养、增强药物疗效和改善免疫微环境来辅助肿瘤治疗。2025年7月1日，南方医科大学南方医院研究团队在" Nature Communications "期刊上发表了一篇题为" Caffeine enhances antitumor T-cell activity by suppressing kynurenine pathway in colorectal cancer "的研究论文。研究显示，咖啡因可以通过调控肿瘤微环境中的犬尿氨酸代谢途径，来增强抗肿瘤T细胞活性，从而显著增强抗肿瘤免疫反应，为咖啡因作为饮食干预手段增强癌症免疫治疗效果提供了科学依据。图：论文截图在这项研究中，研究人员首先分析了UK Biobank数据中人类数据，分析了咖啡因与CRC患者预后和生存率关联，接着在小鼠模型中分析了咖啡因对多种结直肠癌模型生长和生存的影响。对人类数据分析发现，高咖啡因摄入与CRC患者预后改善显著相关。在小鼠模型中，用0.1%咖啡因饮水处理，显著减少了腺瘤数量和肿瘤重量，延长了生存时间，且无明显毒副作用。咖啡因处理抑制肿瘤生长（图：论文截图）流式细胞术和免疫组化分析显示，咖啡因处理显著增加了CD8+ T细胞数量，降低了其耗竭标志物的表达。进一步分析发现，咖啡因通过下调肿瘤细胞中的COL12A1蛋白表达，减少免疫抑制代谢物犬尿氨酸（Kyn）的产生，从而缓解CD8+ T细胞耗竭，增强其杀伤活性，从而抑制肿瘤生长。COL12A1蛋白在多种癌症中高表达，与预后不良和免疫细胞浸润减少相关，并且COL12A1作为咖啡因调控的关键基因，在咖啡因抗肿瘤效果中起关键作用，表明COL12A1可能作为预测免疫疗法反应的生物标志物。从机制上讲，COL12A1通过MAPK-IDO1轴调节犬尿氨酸的产生，特别是通过激活p-ERK1/2来影响IDO1的表达，进而降低犬尿氨酸的产生，缓解CD8+ T细胞耗竭，抑制肿瘤生长。咖啡因增强PD-1抗体免疫疗法的效果（图：论文截图）在多种结直肠癌小鼠模型中，咖啡因与PD-1抗体联合使用可进一步增强抗癌效果，显著抑制了肿瘤生长，提高了生存率，并增强了CD8+ T细胞的杀伤活性和增殖能力。研究人员表示，这项研究首次揭示了咖啡因通过代谢重编程增强抗肿瘤免疫的分子机制，为饮食干预与癌症治疗的结合开辟了新路径。未来需进一步优化临床剂量，并探索不同患者代谢差异对疗效的影响。研究指出，尽管这项研究表明咖啡因具有增强抗癌免疫的潜力，但目前尚不清楚人类的治疗剂量，临床研究表明，适量摄入咖啡因（每天200-400毫克）通常是安全的，并且可能对免疫功能产生有益作用。未来的研究需要进一步探索咖啡因在人类CRC治疗中的最佳剂量、安全性和疗效。综上，这项研究揭示了咖啡因抑制结直肠癌进展的分子机制，并表明咖啡因可以作为一种饮食干预手段，增强PD-1免疫疗法的效果。此外，COL12A1可能作为预测免疫疗法反应的生物标志物。参考文献：https://doi.org/10.1038/s41467-025-60958-0 喜欢我们文章的朋友点个“在看”和“赞”吧，不然微信推送规则改变，有可能每天都会错过我们哦~免责声明“汇聚南药”公众号所转载文章来源于其他公众号平台，主要目的在于分享行业相关知识，传递当前最新资讯。图片、文章版权均属于原作者所有，如有侵权，请在留言栏及时告知，我们会在24小时内删除相关信息。信息来源：依诺维往期推荐本平台不对转载文章的观点负责，文章所包含内容的准确性、可靠性或完整性提供任何明示暗示的保证。

免疫疗法

2025-06-12

·梅斯医学

在现代打工人的“续命”清单里，咖啡几乎永远稳居C位。它不是灵丹妙药，却有着让人欲罢不能的魔力：困了提神，累了清醒，还是无处不在的社交“润滑剂”。尤其那一口微苦焦香、回味绵长，仿佛能把人从“生无可恋”的状态拉回到“还有点盼头”的世界。不过，并不是所有人都能毫无顾虑地畅饮咖啡。有人代谢咖啡因较慢，哪怕下午只喝一杯，也可能彻夜难眠。于是，“脱咖啡因咖啡”（以下简称脱因咖啡）就成了理想替代：既保留了熟悉的香气和口感，又不至于扰乱生物钟，听起来堪称完美。但美好的表象背后，有时候也藏着让人隐隐不安的角落。目前市面上一部分脱因咖啡，是通过一种叫二氯甲烷的化学溶剂去除咖啡因的。这种物质虽然有效，却已被国际癌症研究机构（IARC）列为2B类致癌物。那问题来了：长期喝这种脱因咖啡，会不会真的增加癌症风险？哈佛大学公共卫生学院的研究团队近期在Annals of Oncology上发布的一项重磅研究[1]，给出了一个略显扎心的答案。在从不吸烟的男性中，喝脱咖啡因咖啡与膀胱癌风险升高显著相关。与从不喝的人相比，每天喝0.1–0.9杯（1杯约240ml）、1–1.9杯、2–2.9杯、3杯或以上，风险分别增加30%、42%、43%和79%。不过，这种关联仅出现在男性身上，在女性中没有观察到相似风险。“功”与“过”并存：脱因咖啡的复杂面孔但这个结果很快出现了“反转”，当研究者把人群限定在“从不吸烟者”后发现，不论男女，脱咖啡因咖啡与肺癌的风险不再有关。也就是说，这很可能是吸烟行为“背锅”了：脱因咖啡的重度饮用者中，往往也存在更多的老烟民，从而掩盖了脱因咖啡与肺癌之间的真实关系。不过，与肺癌的“虚惊一场”不同，膀胱癌的风险上升却并不容易被简单归咎于吸烟。更令人揪心的是，即便把吸烟这个混杂因素剔除，结果反而更加“扎眼”。在男性从不吸烟者中，脱因咖啡摄入量与膀胱癌风险之间的关联不仅依然存在，而且更为显著。尽管如此，这项研究也并非只传递“坏消息”。在某些癌症类型中，脱因咖啡的摄入甚至可能具有一定的保护作用。换言之，脱咖啡因咖啡并非“全然有害”或“全然有益”，它与癌症之间的关系高度依赖于癌症类型、性别等特征。那么，脱咖啡因咖啡究竟为何会与膀胱癌风险挂上钩？研究人员给出了一个最具“嫌疑”的解释：脱因工艺中可能残留的化学物质，尤其是二氯甲烷。这是一种曾被广泛用于脱除咖啡因的有机溶剂。虽然早在1990年代，美国FDA就已规定咖啡中的二氯甲烷残留量不得超过10 ppm，但现实是，即使经过高温烘焙和干燥处理，仍可能有2–3 ppm的残留。虽然这一水平远低于监管限值，理论上也属于“安全范围”，但问题在于——膀胱的特殊生理结构，可能让这些微量残留产生意想不到的影响。作为人体的“尿液储存罐”，膀胱不仅直接接触尿液，还负责浓缩体内代谢废物。二氯甲烷在体内代谢后会产生碳氧血红蛋白和一氧化碳，长期、小剂量的暴露，可能对膀胱上皮细胞造成持续性的氧化压力和细胞损伤。也就是说，即便每日摄入量不高，年复一年地“喝下去”，是否真的无害，还不能轻易下结论。更令人疑惑的是，膀胱癌风险上升只出现在喝脱因咖啡的男性身上，女性则没有类似趋势。研究人员推测，这或许和男女性在代谢致癌物方面存在生理差异有关。男性和女性在体内处理有害化合物时的酶表达、代谢通路不同，可能导致膀胱上皮细胞受到的实际暴露水平也不一样。总的来说，这项研究提示，在男性中观察到脱因咖啡摄入量较高与膀胱癌风险升高相关，如果仅限于从不吸烟者，这种正相关性还会变得更强；而在女性中未发现这种关联。“脱因”有残留，“带因”也不省心既然脱因咖啡看似“去除了刺激”，却可能因脱因工艺中的化学残留埋下健康隐患，那自然就让人产生另一个疑问：我们日常喝的“正常”咖啡，保留了咖啡因，是否安全呢？带着这个疑问，来自哈尔滨医科大学附属肿瘤医院的研究团队展开了另一项研究，并将成果发表于European Journal of Nutrition[2]。这一次，他们的关注点不是咖啡的“种类”，而是我们体内真实存在的血浆咖啡因水平。而研究结果，再次为“咖啡与癌症”的关系敲响了警钟。那么，咖啡因究竟是如何“翻车”的？对此，研究者也提出了其中潜在的机制：其一，抗氧化能力的下降被认为是促进肺部细胞发生癌变的关键路径之一。一旦咖啡因削弱了抗氧化系统，细胞更容易受到氧化应激和DNA损伤，从而可能提高癌症风险。另外，咖啡因还有一个“隐蔽身份”——ATM激酶的抑制剂。ATM激酶是一种在细胞遭遇DNA损伤时启动“自救程序”的重要信号分子，它能激活下游的p53通路，引导受损细胞走向程序性凋亡，防止其“带伤上阵”。但如果咖啡因抑制了ATM的活性，p53通路就可能“失灵”，坏掉的细胞无法被及时清除，反而可能继续分裂、扩散，最终发展为肿瘤。日常多喝一杯，肺癌风险上升6%事实上，咖啡因在体内的代谢并不是一视同仁，它主要依赖肝脏中的一种酶——CYP1A2。然而，这种酶的活性在不同人之间差异巨大：有的人代谢咖啡因非常迅速，血浆中的咖啡因浓度很快就下降；而有的人则代谢缓慢，即使喝得不多，体内咖啡因水平依然可能持续偏高。这也就引出了一个现实又让人困惑的问题——既然每个人对咖啡因的“处理能力”不一样，而血浆咖啡因又很难在日常中检测，我们到底该怎么判断：每天喝多少咖啡才算“安全线”以内？为此，一项发表在Nature子刊 Scientific Reports[3]的研究，给出了一个值得参考的答案。这项研究“量化”分析了咖啡摄入量与肺癌风险之间的关系。结果发现，与从不喝咖啡的人相比，经常喝咖啡的人群，肺癌风险上升了28%。这意味着，即使是日常“多喝一杯”的小习惯，也可能悄悄推高健康风险。看到这里，相信不少“咖啡党”已经陷入纠结：难道以后真的要“戒咖啡”了吗？毕竟，关于咖啡的健康益处，过往可谓“证据如山”。许多研究都从不同角度指出，适量饮用咖啡可能对健康有益。例如，南方医科大学毛琛教授团队曾在Annals of Internal Medicine发表一项大型前瞻性队列研究[4]，结果显示：无论是喝无糖咖啡还是加糖咖啡，每天饮用1.5–3.5杯的人群，其全因死亡风险可下降28%–31%。换句话说，适量喝咖啡，确实可能对健康“加分”。但别急着举杯庆祝——同一研究也指出：一旦每天饮用超过4.5杯，全因死亡风险不降反升，甚至会增加5%。这意味着，即使咖啡再香，也不能贪杯。咖啡，还真是让人又爱又恨。它就像一只神秘的万花筒，每转动一次，都能折射出不同的健康信号。但这并不意味着我们就要对咖啡“翻脸不认人”，更没必要盲目把它捧上神坛。对于我们这些咖啡的忠实粉丝来说，关键不在于完全戒掉它，而是在享受它的美味和提神效果时，牢记“适可而止”的原则。反正对小编来说，如果早上不来一杯咖啡，根本没法“开机”工作。而所谓的“脱因咖啡”和“来一碗牛肉面不要牛肉”到底有什么区别？仍需指出的是，研究[1]和研究[3]均不能直接推断因果关系；研究[2]仅包括芬兰人群，咖啡因对不同地理人群癌症风险的遗传效应尚不清楚。参考资料：[1]Zhang Y, Ma C, Zhao L, Mucci LA, Giovannucci EL. Decaffeinated coffee consumption and risk of total and site-specific cancer. Ann Oncol. 2025 Apr 1:S0923-7534(25)00129-2. doi: 10.1016/j.annonc.2025.03.018. Epub ahead of print. PMID: 40180122.[2]Wang, H., Ma, K., Shan, M.et al.Assessing the genetic estimates of the association between plasma caffeine and cancer risk through Mendelian randomization. Eur J Nutr 64, 145 (2025). https://doi.org/10.1007/s00394-025-03663-4[3] Jabbari, M., Salari-Moghaddam, A., Bagheri, A.et al. A systematic review and dose–response meta-analysis of prospective cohort studies on coffee consumption and risk of lung cancer. Sci Rep 14, 14991 (2024). https://doi.org/10.1038/s41598-024-62619-6[4]Liu D, Li ZH, Shen D, Zhang PD, Song WQ, Zhang WT, Huang QM, Chen PL, Zhang XR, Mao C. Association of Sugar-Sweetened, Artificially Sweetened, and Unsweetened Coffee Consumption With All-Cause and Cause-Specific Mortality : A Large Prospective Cohort Study. Ann Intern Med. 2022 May 31. doi: 10.7326/M21-2977. Epub ahead of print. PMID: 35635846.撰文 | 木白编辑 | 木白●重磅！卫健委：两类职称全部“以考代评”，成果代表作制度确立！高校教师也能评卫生类高级职称！抗疫优待政策，多省明年正式退出历史舞台●颠覆！“父亲的性染色体决定孩子性别”被打破？Nature：母亲孕期铁元素缺乏竟能让儿子变女儿！● 主任开始“躺”了！医生：心血管介入术以前都是自己把持，不轻易传授，现在年轻医生想做就做！集采有利于技术的传播，有利于遏制刀霸？版权说明：梅斯医学（MedSci）是国内领先的医学科研与学术服务平台，致力于医疗质量的改进，为临床实践提供智慧、精准的决策支持，让医生与患者受益。欢迎个人转发至朋友圈，谢绝媒体或机构未经授权以任何形式转载至其他平台。点击下方「阅读原文」立刻下载梅斯医学APP！

临床研究

2025-05-29

·Science Daily

How does coffee affect a sleeping brain?

Coffee can help you stay awake. But what does caffeine actually do to your brain once you're asleep? Using AI, a team of researchers has an answer: it affects the brain's 'criticality'. Caffeine is not only found in coffee, but also in tea, chocolate, energy drinks and many soft drinks, making it one of the most widely consumed psychoactive substances in the world. In a study published in April in Nature Communications Biology, a team of researchers from Université de Montréal shed new light on how caffeine can modify sleep and influence the brain's recovery -- both physical and cognitive -- overnight. The research was led by Philipp Thölke, a research trainee at UdeM's Cognitive and Computational Neuroscience Laboratory (CoCo Lab), and co-led by the lab's director Karim Jerbi, a psychology professor and researcher at Mila -- Quebec AI Institute. Working with with sleep-and-aging psychology professor Julie Carrier and her team at UdeM's Centre for Advanced Research in Sleep Medicine, the scientists used AI and electroencephalography (EEG) to study caffeine's effect on sleep. They showed for the first time that caffeine increases the complexity of brain signals and enhances brain "criticality" during sleep. Interestingly, this was more pronounced in younger adults. "Criticality describes a state of the brain that is balanced between order and chaos," said Jerbi. "It's like an orchestra: too quiet and nothing happens, too chaotic and there's cacophony. Criticality is the happy medium where brain activity is both organized and flexible. In this state, the brain functions optimally: it can process information efficiently, adapt quickly, learn and make decisions with agility." Added Carrier: "Caffeine stimulates the brain and pushes it into a state of criticality, where it is more awake, alert and reactive While this is useful during the day for concentration, this state could interfere with rest at night: the brain would neither relax nor recover properly." 40 adults studied To study how caffeine affects the sleeping brain, Carrier's team recorded the nocturnal brain activity of 40 healthy adults using an electroencephalogram. They compared each participant's brain activity on two separate nights -- one when they consumed caffeine capsules three hours and then one hour before bedtime, and another when they took a placebo at the same times. "We used advanced statistical analysis and artificial intelligence to identify subtle changes in neuronal activity," said Thölke, the study's first author. "The results showed that caffeine increased the complexity of brain signals, reflecting more dynamic and less predictable neuronal activity, especially during the non-rapid eye movement (NREM) phase of sleep that's crucial for memory consolidation and cognitive recovery." The researchers also discovered striking changes in the brain's electrical rhythms during sleep: caffeine attenuated slower oscillations such as theta and alpha waves -- generally associated with deep, restorative sleep -- and stimulated beta wave activity, which is more common during wakefulness and mental engagement. "These changes suggest that even during sleep, the brain remains in a more activated, less restorative state under the influence of caffeine," says Jerbi, who also holds the Canada Research Chair in Computational Neuroscience and Cognitive Neuroimaging. "This change in the brain's rhythmic activity may help explain why caffeine affects the efficiency with which the brain recovers during the night, with potential consequences for memory processing." People in their 20s more affected The study also showed that the effects of caffeine on brain dynamics were significantly more pronounced in young adults between ages 20 and 27 compared to middle-aged participants aged 41 to 58, especially during REM sleep, the phase associated with dreaming. Young adults showed a greater response to caffeine, likely due to a higher density of adenosine receptors in their brains. Adenosine is a molecule that gradually accumulates in the brain throughout the day, causing a feeling of fatigue. "Adenosine receptors naturally decrease with age, reducing caffeine's ability to block them and improve brain complexity, which may partly explain the reduced effect of caffeine observed in middle-aged participants," Carrier said. And these age-related differences suggest that younger brains may be more susceptible to the stimulant effects of caffeine. Given caffeine's widespread use around the world, especially as a daily remedy for fatigue, the researchers stress the importance of understanding its complex effects on brain activity across different age groups and health conditions. They add that further research is needed to clarify how these neural changes affect cognitive health and daily functioning, and to potentially guide personalized recommendations for caffeine intake.

临床结果

100 项与枸橼酸咖啡因相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D07603	枸橼酸咖啡因	N06BC01	DB00201

研发状态

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10 条最早获批的记录,

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适应症	国家/地区	公司	日期
新生儿呼吸暂停	加拿大	CHIESI Farmaceutici SpA	2020-03-04
呼吸暂停	美国	Hikma Pharmaceuticals USA, Inc.	1999-09-21

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适应症	最高研发状态	国家/地区	公司	日期
神经肌肉阻滞逆转	临床1期	美国	The University of Chicago	2023-05-01

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适应症

分期

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT06195137 (Pubmed \| J Oral Rehabil)	N/A	口灼伤综合征	118	Caffeine 120-150 mg	鬱窪繭糧願鬱淵憲衊鑰(繭蓋淵構築顧窪壓鏇膚) = 壓繭窪壓壓艱襯襯糧簾壓獵鹽衊憲糧醖壓網觸 (壓糧鹹餘構醖餘範襯蓋 )	积极	2025-03-14
				Alpha-Lipoic Acid 200 mg	鬱窪繭糧願鬱淵憲衊鑰(繭蓋淵構築顧窪壓鏇膚) = 構襯構鏇網積鑰遞廠簾壓獵鹽衊憲糧醖壓網觸 (壓糧鹹餘構醖餘範襯蓋 )
NCT04950660 (CTgov)	临床4期	雄激素不敏感综合征 \| 疼痛 \| 特发性脊柱侧弯	61	Caffeine Tablet (Caffeine Arm)	夢網艱鬱廠鹹顧齋憲壓(觸鹽夢襯齋艱願積製繭) = 艱衊齋構醖齋網衊壓艱簾醖製鹽憲壓夢網壓夢 (網窪構糧醖襯鏇製鹹獵, 0.41) 更多	-	2025-02-21
				Placebo+Caffeine Tablet (Placebo Arm)	夢網艱鬱廠鹹顧齋憲壓(觸鹽夢襯齋艱願積製繭) = 膚蓋壓鬱廠鬱衊衊選築簾醖製鹽憲壓夢網壓夢 (網窪構糧醖襯鏇製鹹獵, 0.33) 更多
NCT03913221 (CTgov)	临床1期	缺氧缺血性脑病	17	Caffeine Citrate 5 mg/kg (Low Dose Caffeine (5 mg/kg))	憲衊壓齋構衊醖鬱範夢(繭鬱憲餘壓淵範構願網) = 夢壓選窪餘範壓遞醖廠糧廠餘範構夢鹹糧夢艱 (鹹構簾顧醖膚衊窪衊壓, 324.96) 更多	-	2024-09-19
				Caffeine Citrate 10 mg/kg (High Dose Caffeine (10 mg/kg))	憲衊壓齋構衊醖鬱範夢(繭鬱憲餘壓淵範構願網) = 壓製獵糧餘餘鏇繭獵築糧廠餘範構夢鹹糧夢艱 (鹹構簾顧醖膚衊窪衊壓, 134.42) 更多
NCT03340727 (MoCHA, CTgov)	临床3期	呼吸暂停	827	Placebo	夢廠壓壓築鬱夢鹹觸繭(糧膚蓋鑰蓋鬱鏇遞網壓) = 襯齋壓顧築積積顧艱餘簾網願窪鬱淵醖衊築範 (鹹積廠鹹選築窪襯構膚, 廠膚選簾餘廠遞積範願 ~ 齋願餘範觸艱網顧淵範) 更多	-	2024-06-28
NCT05919732 (CTgov)	临床4期	腹股沟疝	20	Dexmedetomidine+Tylenol+Bupivacaine+Caffeine (Caudal Infusion)	繭獵廠鹽鏇鏇構遞壓壓 = 膚衊膚鹽窪簾積夢網簾餘遞遞網範範艱簾齋壓 (窪構選齋積餘範願鏇糧, 夢壓網餘構製窪窪衊淵 ~ 艱窪鑰鹽鹹齋鹽築鑰憲) 更多	-	2024-04-02
				Tylenol+Propofol+caffeine+bupivacaine+rocuronium (General Anesthesia)	繭獵廠鹽鏇鏇構遞壓壓 = 淵築壓鹹淵餘鬱鏇窪製餘遞遞網範範艱簾齋壓 (窪構選齋積餘範願鏇糧, 鹹醖憲衊網艱憲齋夢膚 ~ 餘積製網艱鬱鹽鬱鏇齋) 更多
NCT02323698 (CTgov)	临床1/2期	脊髓损伤 \| 缺氧	36	AIH+Caffeine (Caffeine/AIH)	鹹憲選淵繭鏇鹹鬱製範(鏇鑰醖鹹夢蓋糧網積醖) = 餘簾餘鹽簾築壓窪積艱顧遞鬱願鹹築鬱構艱壓 (廠憲廠選製壓艱膚蓋蓋, 2.2) 更多	-	2022-08-09
				Placebo (Placebo/AIH)	鹹憲選淵繭鏇鹹鬱製範(鏇鑰醖鹹夢蓋糧網積醖) = 範齋鹹窪鏇壓遞艱襯願顧遞鬱願鹹築鬱構艱壓 (廠憲廠選製壓艱膚蓋蓋, 2.2) 更多
NCT03577730 (CTgov)	早期临床1期	术后疼痛	71	Caffeine Citrate (Experimental)	範簾顧齋衊網鏇憲網繭(憲鑰顧鹽鹹膚網艱顧鬱) = 淵膚齋築衊積醖製簾顧廠範願鑰獵鬱構顧鑰鏇 (淵窪顧醖鹽遞鑰獵顧壓, 鏇糧憲鏇範淵遞齋顧膚 ~ 獵鏇鏇醖構衊廠網構鏇) 更多	-	2021-10-06
				Dextrose Water (Control)	範簾顧齋衊網鏇憲網繭(憲鑰顧鹽鹹膚網艱顧鬱) = 夢鹹憲窪廠構艱醖鬱壓廠範願鑰獵鬱構顧鑰鏇 (淵窪顧醖鹽遞鑰獵顧壓, 憲齋廠齋鏇鹹艱蓋築淵 ~ 簾廠憲衊齋窪廠廠範夢) 更多
NCT01629329 (Migraine, CTgov)	临床4期	急性偏头痛	93	Acetaminophen+Caffeine+Aspirin (Aspirin, Acetaminophen, Caffeine Pills)	積網蓋鑰觸窪齋夢醖夢(獵夢蓋艱糧積範鹽鹽鹽) = 糧觸廠壓蓋獵範簾觸鑰觸齋衊鹽鬱築構遞鹽夢 (窪繭鏇鏇鹹築齋窪齋淵, 鹹鑰選鹽衊簾齋夢膚壓 ~ 構糧糧襯構蓋獵鹹夢壓) 更多	-	2020-03-18
				Prochlorperazine (Prochlorperazine 10mg)	積網蓋鑰觸窪齋夢醖夢(獵夢蓋艱糧積範鹽鹽鹽) = 艱壓觸繭積膚網窪積衊觸齋衊鹽鬱築構遞鹽夢 (窪繭鏇鏇鹹築齋窪齋淵, 鹹簾糧製衊壓繭憲夢築 ~ 範蓋製選製選鹽窪繭窪) 更多
NCT02974114 (CTgov)	临床4期	疼痛 \| 急性疼痛 \| 头痛	21	Paracetamol+caffeine (Paracetamol and Caffeine)	窪蓋蓋鹹積遞繭齋蓋憲(鹹繭糧齋齋鏇遞鹹構蓋) = 製願製窪簾衊積憲壓鹽製鑰鹹顧衊鑰簾選鬱選 (壓憲顧襯鬱廠淵繭淵鹹, 積夢觸齋糧築淵獵窪膚 ~ 積壓鹽選構糧壓遞鬱鬱) 更多	-	2018-08-28
				Paracetamol (Paracetamol)	窪蓋蓋鹹積遞繭齋蓋憲(鹹繭糧齋齋鏇遞鹹構蓋) = 顧顧構遞夢蓋艱鹽壓艱製鑰鹹顧衊鑰簾選鬱選 (壓憲顧襯鬱廠淵繭淵鹹, 窪鹽壓蓋網積遞遞觸遞 ~ 繭簾範獵鑰淵襯繭構製) 更多
NCT02567968 (CTgov)	临床4期	麻醉	8	Placebo Control (Placebo)	衊夢壓鬱襯壓鏇遞鏇構(鑰選夢簾壓蓋選淵鏇艱) = 鹽簾鹹簾簾淵廠憲鏇鏇範鹹夢餘醖艱糧積築壓 (構積壓淵簾鹹淵醖膚鬱, 3.9) 更多	-	2018-07-18
				Caffeine (Caffeine)	衊夢壓鬱襯壓鏇遞鏇構(鑰選夢簾壓蓋選淵鏇艱) = 齋鏇醖淵鹹獵餘簾憲壓範鹹夢餘醖艱糧積築壓 (構積壓淵簾鹹淵醖膚鬱, 5.1) 更多