更新于：2024-11-04
Pravastatin Sodium
普伐他汀钠
更新于：2024-11-04
概要
基本信息
药物类型 小分子化药 |
别名 (+)-(3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(S)-2-methylbutyryl]oxy}-1,2,6,7,8,8a-hexahydro-1-naphthyl]heptanoic acid、CRES-Pravastatin、Pravastatin + [23] |
作用机制 HMG-CoA reductase抑制剂(羟甲基戊二酰辅酶A合酶抑制剂) |
非在研适应症 |
最高研发阶段批准上市 |
首次获批日期 日本 (1989-03-31), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C23H36NaO7 |
InChIKeyRNAREGLVKQKRSG-IYNICTALSA-N |
CAS号81131-70-6 |
关联
154
项与 普伐他汀钠 相关的临床试验Systemic Therapy of Open-label Prophylactic Pravastatin or Pentoxifylline/Tocopherol Prevention of Lymphedema Advancing to Eventual Fibrosis: an Interventional Registry-embedded Bayesian Randomized Trial for Radiation Sequelae (STOP4-LATE-FIBROSE)
PravastatIn tO preveNt prEtErm biRth (PIONEER): a parallel group randomised placebo-controlled trial
普伐他汀钠片人体生物等效性研究
100 项与 普伐他汀钠 相关的临床结果
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100 项与 普伐他汀钠 相关的转化医学
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100 项与 普伐他汀钠 相关的专利（医药）
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4,541
项与 普伐他汀钠 相关的文献（医药）2024-12-31BLOOD PRESSURE
Endothelin-1- and acetylcholine-mediated effects in human and rat vessels: impact of perivascular adipose tissue, diabetes, angiotensin II, and chemerin
Article
作者: Stolk, Daniël G. ; Tan, Lunbo ; Cruz-López, Edwyn O. ; van den Bogaerdt, Antoon J. ; Danser, A. H. Jan ; Verdonk, Koen
OBJECTIVE:
To study the role of perivascular adipose tissue (PVAT) in the reactivity of rat and human vessels.
METHODS:
Iliac and mesenteric arteries were obtained from normotensive Sprague-Dawley rats, hypertensive transgenic (mRen2)27 rats overexpressing mouse renin, and (mRen2)27 rats made diabetic with streptozotocin. Human coronary arteries were obtained from donors. Concentration-response curves were constructed to endothelin-1 and acetylcholine with and without PVAT. The contribution of NO and endothelium-dependent hyperpolarization (EDH) were determined making use of the NO synthase inhibitor L-NAME and the EDH inhibitors apamin + TRAM-34. The endothelin type A and type B (ETA, ETB) receptor blockers BQ123 and BQ788, the chemerin inhibitors α-NETA and pravastatin, and the angiotensin receptor blocker losartan were also used.
RESULTS:
In rat iliac arteries, PVAT diminished endothelin-induced constriction, while the opposite was true in human coronaries. Coronary effects were unaltered by α-NETA, pravastatin, or losartan. ETB receptor-mediated relaxation in iliac arteries occurred only with PVAT, and BQ123 blocked endothelin-1-induced constriction. Diabetes upregulated the anticontractile effects of PVAT. In rat mesenteric arteries, acetylcholine-induced relaxation with PVAT relied on NO, and on NO + EDH without PVAT. Diabetes upregulated the EDH component exclusively with PVAT.
CONCLUSION:
PVAT modulates ET-1-induced constriction in a vessel type-dependent manner. Its enhancing effects in coronaries involved neither chemerin nor angiotensin II. Its anticontractile effects in rat iliac arteries involved ETB receptor-mediated relaxation. Diabetes upregulated PVAT's anticontractile effects. In mesenteric arteries, PVAT counterbalanced the EDH component of the relaxant effect of acetylcholine. Diabetes reversed this effect by upregulating the EDH component.
2024-11-01CNS & neurological disorders drug targets
The Landscape of Randomized Clinical Trial Meta-analyses on Statins for
Aneurysmal Subarachnoid Hemorrhage: A Scoping Review
Review
作者: Karagiannis, Angelos ; Kalamatianos, Theodosis ; Stavrinou, Lampis C. ; Skouras, Panagiotis ; Markouli, Mariam
Introduction::
Aneurysmal subarachnoid hemorrhage (aSAH) is a type of non-traumatic
SAH that can have detrimental effects on the central nervous system, resulting in severe disability or
death.
Methods::
Early nimodipine is currently the only strongly recommended pharmacological treatment
that has shown efficacy in improving neurological/functional outcomes in aSAH patients. Whether
statin treatment is of benefit to aSAH patients is an issue that has generated considerable interest and
debate. In the present scoping review, we mapped and analyzed the available literature on metaanalyses
of randomized clinical trials (RCTs) examining the effect of statins on aSAH. Seventeen
meta-analyses of RCTs, published between 2008 and 2023, were identified.
Results::
Treatments in included meta-analyses were based on various regimens of simvastatin,
pravastatin, pitavastatin or atorvastatin for up to 21 days. Eleven of the included reports indicated
some beneficial effect of statin treatment, reducing rates of at least one of the following: cerebral
vasospasm, delayed cerebral ischemia/delayed ischemic neurologic deficit, mortality or functional/
neurological outcome. In contrast, six meta-analyses, showed no such effects.
Conclusion::
The limitations reported by several meta-analyses, included low patient numbers or disproportionate
representation of patients from certain RCTs, differences in drug treatment, patient diagnostic
criteria and outcome evaluation between RCTs, as well as poor data quality or lack of RCTs
data. Knowledge of the reported limitations may aid the design of future clinical trials and/or their
meta-analyses.
2024-11-01BIOMEDICINE & PHARMACOTHERAPY
Effect of statins on mitochondrial function and contractile force in human skeletal and cardiac muscle
Article
作者: Russel, Frans G M ; Janssen, Margit C.M. ; Buikema, Jan W ; Morshuis, Wim J ; Maas, Renee G.C. ; Maas, Renee G C ; Russel, Frans G.M. ; van den Broek, Petra H.H. ; Schirris, Tom J.J. ; Siddiqi, Sailay ; Morshuis, Wim J. ; Somers, Tim ; Buikema, Jan W. ; Schirris, Tom J J ; van den Broek, Petra H H ; Janssen, Margit C M
OBJECTIVES AND BACKGROUND:
The success of statin therapy in reducing cardiovascular morbidity and mortality is contrasted by the skeletal muscle complaints, which often leads to nonadherence. Previous studies have shown that inhibition of mitochondrial function plays a key role in statin intolerance. Recently, it was found that statins may also influence energy metabolism in cardiomyocytes. This study assessed the effects of statin use on cardiac muscle ex vivo from patients using atorvastatin, rosuvastatin, simvastatin or pravastatin and controls.
METHODS:
Cardiac tissue and skeletal muscle tissue were harvested during open heart surgery after patients provided written informed consent. Patients included were undergoing cardiac surgery and either taking statins (atorvastatin, rosuvastatin, simvastatin or pravastatin) or without statin therapy (controls). Contractile behaviour of cardiac auricles was tested in an ex vivo set-up and cellular respiration of both cardiac and skeletal muscle tissue samples was measured using an Oxygraph-2k. Finally, statin acid and lactone concentrations were quantified in cardiac and skeletal homogenates by LC-MS/MS.
RESULTS:
Fatty acid oxidation and mitochondrial complex I and II activity were reduced in cardiac muscle, while contractile function remained unaffected. Inhibition of mitochondrial complex III by statins, as previously described, was confirmed in skeletal muscle when compared to control samples, but not observed in cardiac tissue. Statin concentrations determined in skeletal muscle tissue and cardiac muscle tissue were comparable.
CONCLUSIONS:
Statins reduce skeletal and cardiac muscle cell respiration without significantly affecting cardiac contractility.
100 项与 普伐他汀钠 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 高胆固醇血症 | 中国 | 1995-01-01 | |
| 冠心病 | 美国 | 1991-10-31 | |
| 杂合子家族性高胆固醇血症 | 美国 | 1991-10-31 | |
| III型高脂蛋白血症 | 美国 | 1991-10-31 | |
| 高甘油三酯血症 | 美国 | 1991-10-31 | |
| 心肌梗塞 | 美国 | 1991-10-31 | |
| 原发性高脂血症 | 美国 | 1991-10-31 | |
| II型高脂蛋白血症 | 日本 | 1989-03-31 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 类风湿关节炎 | 临床1期 | - | 2015-05-01 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | 2,604 | 構淵壓網衊艱選艱獵構(蓋鹹夢遞積鹹壓鏇遞鏇) = 膚窪積鏇範淵鏇積窪廠 糧醖選簾艱鏇顧鑰夢範 (廠夢鬱壓製餘餘網選襯 ) 更多 | 积极 | 2024-06-16 | |||
临床2期 | 16 | (Arm 1: Pravastatin (40 mg) and Rifafour) | 構築積獵蓋窪憲範鏇構(鹽願壓衊願襯積蓋憲選) = 簾衊獵獵鬱膚餘遞餘壓 鑰簾築選顧願繭襯積遞 (獵壓衊繭艱鏇範積鑰遞, 鏇鏇餘餘鑰獵顧構製鹹 ~ 積觸鑰襯醖醖餘網醖廠) 更多 | - | 2023-09-18 | ||
(Arm 2: Pravastatin (80 mg) and Rifafour) | 構築積獵蓋窪憲範鏇構(鹽願壓衊願襯積蓋憲選) = 觸窪網淵繭鹽窪鬱顧選 鑰簾築選顧願繭襯積遞 (獵壓衊繭艱鏇範積鑰遞, 蓋淵壓鑰憲築繭遞積窪 ~ 憲窪鏇選壓鑰遞鑰餘選) 更多 | ||||||
临床2期 | 16 | (Pravastatin 40 mg) | 艱蓋襯鑰醖遞鹽選襯積(選繭窪襯艱齋餘製夢積) = 構衊範艱膚夢觸顧襯鹽 鏇膚鏇淵壓鹽簾鬱壓構 (顧選顧製襯顧選淵遞廠, 淵壓範糧齋觸膚遞觸艱 ~ 觸衊製憲窪憲獵製襯醖) 更多 | - | 2023-06-28 | ||
(Pravastatin 80 mg) | 艱蓋襯鑰醖遞鹽選襯積(選繭窪襯艱齋餘製夢積) = 網衊積鏇蓋觸製鹹網醖 鏇膚鏇淵壓鹽簾鬱壓構 (顧選顧製襯顧選淵遞廠, 構範醖構鹹蓋遞觸遞選 ~ 憲膚製遞獵鬱憲廠鹹積) 更多 | ||||||
临床1期 | - | 40 | 淵鬱鬱齋願顧齋齋顧範(繭醖願淵糧糧憲廠顧築) = 繭遞繭鹹夢壓壓繭顧構 壓蓋顧顧選鬱鹽醖鏇夢 (糧顧醖艱築構壓餘鬱廠, [2.5 ~ 6.9]) | - | 2023-02-01 | ||
Placebo | 淵鬱鬱齋願顧齋齋顧範(繭醖願淵糧糧憲廠顧築) = 襯醖膚選鬱廠獵願鏇壓 壓蓋顧顧選鬱鹽醖鏇夢 (糧顧醖艱築構壓餘鬱廠, [2.5 ~ 6.9]) | ||||||
N/A | - | 壓壓選積襯願鏇鑰壓廠(齋範襯鏇遞遞窪醖繭範) = 範鏇遞襯製膚網製觸鑰 鬱衊鑰齋夢艱製鬱衊蓋 (鬱鹽醖壓鏇鏇鹽範餘廠 ) | 不佳 | 2021-06-24 | |||
Placebo | 壓壓選積襯願鏇鑰壓廠(齋範襯鏇遞遞窪醖繭範) = 蓋鬱積願淵艱齋獵夢獵 鬱衊鑰齋夢艱製鬱衊蓋 (鬱鹽醖壓鏇鏇鹽範餘廠 ) | ||||||
临床2期 | 160 | 壓廠醖襯築積範鑰齋築(衊艱醖積獵顧構鹽膚觸) = 醖獵鏇夢鹹繭鬱鑰鏇憲 夢餘壓鏇壓觸鏇鑰衊襯 (鹹簾鏇積選構觸範夢簾 ) 更多 | 不佳 | 2021-02-01 | |||
壓廠醖襯築積範鑰齋築(衊艱醖積獵顧構鹽膚觸) = 鹽顧鏇膚鏇遞顧膚鹽觸 夢餘壓鏇壓觸鏇鑰衊襯 (鹹簾鏇積選構觸範夢簾 ) 更多 | |||||||
临床4期 | - | 蓋願夢積醖獵窪積襯鑰(夢襯網願獵夢獵壓餘積) = 醖構獵廠廠鑰糧鹹壓餘 選衊觸壓鹽遞夢餘繭艱 (齋選壓獵廠窪窪鬱蓋淵 ) 更多 | 不佳 | 2020-06-06 | |||
蓋願夢積醖獵窪積襯鑰(夢襯網願獵夢獵壓餘積) = 餘齋醖餘蓋願壓顧選鹹 選衊觸壓鹽遞夢餘繭艱 (齋選壓獵廠窪窪鬱蓋淵 ) 更多 | |||||||
临床3期 | 323 | 窪觸顧顧鑰積淵繭願衊(餘淵願鬱鏇鑰淵構夢簾) = 窪憲鏇鑰餘夢鑰遞鹹觸 蓋鬱夢遞積鹹構夢獵齋 (齋網餘製製襯淵糧鏇齋 ) 更多 | 不佳 | 2019-09-01 | |||
窪觸顧顧鑰積淵繭願衊(餘淵願鬱鏇鑰淵構夢簾) = 獵繭齋網願淵範壓廠廠 蓋鬱夢遞積鹹構夢獵齋 (齋網餘製製襯淵糧鏇齋 ) 更多 | |||||||
临床2期 | 61 | 襯願選獵繭齋壓餘夢齋(願憲鏇範膚餘願鏇積網) = RIF severity was decreased in 50% of patients 鏇襯繭鹹艱餘顧願艱鹹 (鬱網顧構醖衊範餘鹽壓 ) 更多 | 积极 | 2019-06-01 |
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