Foritinib Succinate

Revenue Exceed RMB30.9 Billion with R&D Expenditure RMB3.9 Billion Continuing to Consolidate its Dominant Position In The fields of Breast Cancer and Lung Cancer SHANGHAI, Oct. 29, 2024 /PRNewswire/ -- On October 29, Shanghai Fosun Pharmaceutical (Group) Co., Ltd. ("Fosun Pharma" or "the Group"; Stock Code: 600196.SH; 02196.HK), announced its operating performance for the first three quarters of 2024. From January to September 2024, Fosun Pharma achieved revenue of RMB30.91 billion, an increase of about 5.74% YoY after excluding COVID-related products. The net profit attributable to owners of the parent of the Group after deducting extraordinary gain or loss amounted to RMB1.84 billion, up by 24.58% YoY. In 2024, Fosun Pharma will further focus on innovative drugs and high-value devices, and continue to promote lean operations, cost reduction, efficiency improvement, and asset rationalization to optimize assets and financial structure, actively promote supply chain management and operational efficiency, and achieve healthy operating cash flow. In the first three quarters of 2024, the net cash flow from operating activities of Fosun Pharma was RMB2.99 billion, a year-on-year increase of 21.33%; the management expense ratio decreased by 0.15 percentage points YoY; excluding the impact of newly acquired companies, management expenses decreased by approximately RMB300 million on the same basis. Focusing on advantageous therapeutic areas with innovative R&D pipelines continue to advance In terms of innovative R&D, Fosun Pharma continues to focus on advantageous pipelines to achieve efficient results and continuous implementation of innovative products. In the first three quarters of 2024, Fosun Pharma's R&D expenditure totaled RMB3.92 billion. In particular, R&D expenses were RMB2.65 billion. In addition to independent R&D, the Group fully implemented an open R&D model, and incubated and invested in R&D projects by initiating/managing industrial funds and other diversified ways, so as to ensure the sustainability of innovation and R&D. Fosun Pharma's innovative drug business mainly covers the core therapeutic areas of solid tumors, hematological tumors and immuno-inflammatory diseases, with emphasis on the enhancement of the core technology platforms of antibody/ADCs, cellular therapy and small molecules, to create an open and global innovative R&D system, continuously enhance pipeline value, and promote the development and commercialization of its products. In the field of tumor immunotherapy, on September 13, 2024, Fosun Pharma announced it will acquire the 50% stake in Fosun Kite and will wholly own Fosun Kite (now renamed as "Fosun Kairos"). In the future, Fosun Kairos will serve as the core platform of Fosun Pharma's cell therapy, continue to focus on the field of tumor immunotherapy, as well as to promote the development and commercialization of existing licensed products, Axi-Cel (i.e. Fosun Kite's marketed product "Yi Kai Da") and Brexu-Cel (i.e. Fosun Kite's pipeline project FKC889), in Chinese mainland, Hong Kong SAR and Macau SAR with Kite Pharma. In the third quarter of 2024, Fosun Pharma's multiple independently developed innovative products and pipeline clinical trial results were announced in industry conferences and journals, further consolidating its dominant position in the fields of hematological tumors, breast cancer, lung cancer and other tumors. Particularly, the interim analysis results of the Phase III study of Foritinib Succinate (SAF-189s), an innovative drug independently developed to treat ALK-positiveb advanced non-small cell lung cancer (NSCLC), were released during the 2024 World Conference on Lung Cancer ("WCLC"). The above-mentioned studies have found that the overall efficacy of Foritinib Succinate is good. Compared with crizotinib treatment, it can significantly improve PFS and reduce the risk of CNS progression. Its safety is controllable, and no new safety signals appeared after treatment. Faritinib Succinate is expected to break through the current clinical difficulties faced in the treatment of ALK-positive NSCLC and bring new treatment options to NSCLC patients. The multicenter real-world study of Fosun Pharma's self-developed serplulimab-based immunochemotherapy for extensive-stage small cell lung cancer was released at the 2024 WCLC. The ASTRUM-005R study provides additional empirical evidence to support the therapeutic value of serplulimab plus chemotherapy and complements the pivotal data from the ASTRUM-005 clinical trial. Additionally, during the reporting period, the Committee for Medicinal Products for Human Use ("CHMP") of the European Medicines Agency (EMA) issued a positive opinion recommending approval for Fosun Pharma's self-developed serplulimab injection in combination with carboplatin and etoposide for the first-line treatment of adult patients with extensive-stage small cell lung cancer (ES-SCLC). The CHMP's opinion will be submitted to the European Commission (EC) as a reference for marketing authorization approval. Results of the phase 2 study of HLX22, an innovative anti-HER2 monoclonal antibody (mAb), in combination with Han Qu You (trastuzumab) and chemotherapy for the first-line treatment of HER2-positive advanced gastric/gastroesophageal junction (G/GEJ) cancer were presented on 2024 ESMO Gastrointestinal Cancers Congress (ESMO GI) and MED, a flagship clinical and translational research monthly journal by Cell Press. The results showed that add HLX22 to HLX02 (trastuzumab) and chemotherapy as first-line therapy improved efficacy in HER2-positive G/GEJ cancer patients with manageable safety. In September 2024, Fosun Pharma announced the Biologics License Application ("BLA") for the licensed product RT002 (DaxibotulinumtoxinA-lanm, Chinese trademark: 达希斐®) for the temporary improvement in the appearance of moderate to severe glabellar lines associated with corrugator and/or procerus muscle activity in adult patients, was approved by the National Medical Products Administration ("NMPA"), becoming the first DaxibotulinumtoxinA-lanm approved for marketing in Chinese mainland. Additionally, the results of a Phase III multicenter, double-blind, placebo-controlled study conducted in China for the treatment of moderate to severe glabellar lines were published in the Journal of Plastic, Reconstructive & Aesthetic Surgery (JPRAS). The study demonstrates that the product provides durable efficacy and high safety in Chinese patients with moderate to severe glabellar lines. Actively implementing share repurchases and increasing holdings with continuous efforts on enhancing ESG Fosun Pharma, a company listed on both the A-share and H-share markets, and its controlling shareholder Fosun High Tech have actively engaged in share repurchases and increased holdings this year, demonstrating confidence in the Company's future development and further boosting market confidence. In the first three quarters of 2024, Fosun Pharma spent approximately RMB127 million and approximately HKD66.9 million to repurchase around 5.68 million A shares and 5.47 million H shares respectively. As of now, the H Share Repurchase Plan is still valid. In addition, the controlling shareholder Fosun High Tech, has spent a total of approximately RMB101 million to increase its holdings of around 4.30 million A shares of Fosun Pharma, under the latest Shareholding Increase Plan. Founded in 1994 and with three decades of development, Fosun Pharma has grown into a global innovation-driven pharmaceutical and healthcare industry group. The Company always regards innovation as its primary social responsibility, consistently focusing on unmet clinical needs, prioritizing innovative R&D, advancing the launch of innovative products, promoting drug accessibility and affordability, and driving high-quality corporate growth. Fosun Pharma maintained an A grade rating in MSCI ESG Ratings for three consecutive years and an A- rating in HSI ESG, ranking among the top tier in the healthcare industry for pharmaceuticals and biotechnology. It was also selected as a constituent of the Hang Seng (China A) Corporate Sustainability Benchmark Index ("HSCASUSB"), Hang Seng (China A) Corporate Sustainability Index ("HSCASUS"), and Hang Seng (Mainland and HK) Corporate Sustainability Index ("HSMHSUS"). With its sustained excellence in innovation and global operational capabilities, Fosun Pharma has been recognized by multiple authoritative institutions in innovative R&D, ESG and other areas. The Company ranked in the top four of China's 2023 Top 100 Pharmaceutical Industry, was included in the "China Best Managed Companies" List (BMC) for the second consecutive year and was listed in Forbes 2024 China ESG 50. In addition, the Company has actively introduced its independently developed artemisinin-based innovative products to Africa, providing a Chinese solution to the global fight against malaria. This initiative highlights the inclusive, diverse, and open nature of ESG and earned Fosun Pharma recognition as an "Inspirational ESG Case", serving as a model for corporate ESG practices. *** About Fosun Pharma Founded in 1994, Shanghai Fosun Pharmaceutical (Group) Co., Ltd.* ("Fosun Pharma"; stock code: 600196.SH, 02196.HK) is a global innovation-driven pharmaceutical and healthcare industry group. Fosun Pharma directly operates businesses including pharmaceuticals, medical devices, medical diagnosis, and healthcare services. As a shareholder of Sinopharm Co., Ltd., Fosun Pharma expands its areas in the pharmaceutical distribution and retail business. Fosun Pharma is patient-centered and unmet clinical needs-oriented. Through diversified and multi-level cooperation models such as independent research and development, cooperative development, license-in, and industrial investment, the company continues to enrich its innovative product pipeline and focus on differentiated product R&D with high-tech barriers, to continuously enhance the value of its pipeline. Fosun Pharma's innovative products focus on core therapeutic areas such as solid tumors, hematologic tumors and immunity inflammation. It also strengthens core technology platforms such as antibodies/ADC, cell therapy, and small molecules. Guided by the 4IN strategy (Innovation, Internationalization, Intelligentization, and Integration), Fosun Pharma adheres to the business philosophy of "Innovation for Good Health", continues to promote innovative transformation, actively deploys internationalization, strengthens business focus by product lines, promotes integrated operations and efficiency improvement, and is dedicated to being the global leading integrator of pharmaceutical and healthcare innovation. For more information, please visit the official website: SOURCE Fosun Pharma WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

10月29日，复星医药（600196.SH；02196.HK）公布2024年前三季度业绩。2024年1至9月，复星医药实现营业收入人民币309.12亿元，不含新冠相关产品，营业收入同比增长约5.74%；实现归母扣非净利润18.36亿元，同比增长24.58%。 2024年，复星医药进一步聚焦创新药和高值器械，并不断推进精益运营、降本增效和资产轻量化，以优化资产、财务结构，积极推动供应链管理和运营效率的提升，实现健康的经营现金流。2024年前三季度，复星医药经营活动产生的现金流量净额29.87亿元，同比增长21.33%；管理费用率同比下降0.15个百分点；剔除新并购企业影响，管理费用同口径减少约3亿元。 聚焦优势治疗领域，创新研发管线持续推进 创新研发方面，复星医药持续聚焦优势管线，实现高效的成果转化和创新产品的持续落地。2024年前三季度，复星医药研发投入共计39.15亿元；其中，研发费用为26.48亿元。在自研投入的同时，复星医药充分践行开放式研发模式，通过发起设立/管理产业基金等方式开展研发项目的孵化和投入，确保药品创新研发的可持续性。 复星医药的创新药业务聚焦实体瘤、血液瘤、免疫炎症等核心治疗领域，并重点强化抗体/ADC、细胞治疗、小分子等核心技术平台，打造开放式、全球化的创新研发体系，持续提升管线价值，推动产品的研发及商业化。 在肿瘤免疫治疗领域，2024年9月13日，复星医药宣布将增持复星凯特50%的股权以全资控股复星凯特（现已更名为复星凯瑞）。未来，复星凯瑞将作为复星医药细胞治疗技术的核心平台，继续专注于肿瘤免疫治疗领域，并与Kite Pharma继续推进既有许可产品Axi-Cel（即已上市产品“奕凯达”）及Brexu-Cel（即在研项目FKC889）在中国境内及香港、澳门的开发和商业化合作。 2024年第三季度，复星医药多款自主研发的创新产品、管线临床试验结果于行业大会、期刊中公布，进一步巩固在血液瘤、乳腺癌、肺癌等肿瘤领域的优势地位。其中，自主研发的治疗ALK 阳性非小细胞肺癌（NSCLC）的创新药复瑞替尼（Foritinib，即SAF-189s）的III期研究期中分析结果于2024年世界肺癌大会（WCLC）期间发布。上述研究发现，复瑞替尼整体疗效良好，相比于克唑替尼治疗可使PFS显著改善，使CNS进展风险降低，且其安全性可控，治疗后未出现新的安全性信号。复瑞替尼有望突破目前ALK阳性NSCLC治疗所面临的临床困难，为NSCLC患者带来新的治疗选择。 复星医药另一款自主研发的斯鲁利单抗联合化疗一线治疗广泛期小细胞肺癌的真实世界多中心研究数据于2024年世界肺癌大会（WCLC）大会期间公布。真实世界数据验证了临床试验结果，为斯鲁利单抗联合依托泊苷和铂类一线治疗ES-SCLC补充有力证据。此外，报告期内，复星医药自主研发的斯鲁利单抗注射液还获欧洲药品监督管理局（EMA）人用医药产品委员会（Committee for Medicinal Products for Human Use，以下简称“CHMP”）积极审评意见，获推荐批准联合卡铂和依托泊苷适用于广泛期小细胞肺癌（ES-SCLC）成人患者的一线治疗；CHMP的审评意见将会被递交至欧盟委员会（EC），作为上市许可审批的参考。 创新型抗HER2单抗HLX22联合汉曲优（注射用曲妥珠单抗）和化疗用于一线治疗HER2阳性晚期或转移性胃/胃食管交界部（G/GEJ）癌的II期临床研究（HLX22-GC-201）结果相继于2024年欧洲肿瘤学会胃肠道肿瘤研讨会（ESMO GI）和Cell Press细胞出版社旗下的综合性医学旗舰期刊MED发布。已开展的研究结果显示，在HLX02（注射用曲妥珠单抗）联用化疗的基础上加入HLX22可明显改善HER2阳性G/GEJ癌患者一线治疗的效果，且安全性可控。 2024年9月，复星医药获许可产品注射用A型肉毒毒素（中国境内商标：达希斐®）用于暂时性改善成人因皱眉肌和/或降眉间肌活动引起的中度至重度眉间纹的药品上市许可申请获国家药品监督管理局（“国家药监局”）批准，成为首款于中国内地获得上市批准的DaxibotulinumtoxinA-lanm肉毒毒素产品。此外，该产品治疗中度至重度眉间纹的中国III期多中心、双盲、安慰剂对照试验结果于整形美容外科杂志JPRAS发表。该研究结果显示，于中度/重度眉间纹的中国人群，该产品具有持久疗效和良好的安全性。 积极实施回购增持，持续提升ESG治理水平 作为A+H两地上市公司，复星医药及控股股东复星高科今年以来积极开展回购及增持，彰显了对公司未来发展的信心，也进一步提振了市场信心。2024年前三季度，复星医药已斥资约1.27亿人民币及约6,690万港元，分别回购了567.77万股A股及547.15万股H股。截至目前，H股回购方案仍在有效期内。此外，控股股东复星高科技于最新一期增持计划下，累计出资约1.01亿人民币增持复星医药429.50万股A股。 成立于1994年，历经30年的发展，复星医药已成长为一家植根中国、创新驱动的全球化医药健康产业集团，复星医药始终将创新作为企业最重要的社会责任，围绕未被满足的临床需求，持续加强创新研发，推动创新产品上市，促进药品可及可负担，推动公司实现高质量发展。复星医药的MSCI ESG评级连续三年维持A级、恒生ESG评级为A-，位列医疗保健业-药品及生物科技行业第一梯队，并入选恒生A股可持续发展企业基准指数，恒生A股可持续发展企业指数和恒生内地及香港可持续发展企业指数。 凭借持续卓越的创新及全球化运营能力，复星医药在创新研发、ESG等领域获得多家权威机构认可，荣登2023年度中国医药工业百强TOP4，连续第二年登榜“中国卓越管理公司”（BMC），入选福布斯中国2024中国ESG50榜单。同时，复星医药积极将自主研发的青蒿素类创新产品带到非洲，为全球抗疟疾事业提供了中国的创新解决方案，发挥了ESG的包容、多元以及开放的特性，成功入选“ESG启发案例”，为企业ESG实践提供启发和借鉴。 Copyright © 2024 PHARMCUBE. All Rights Reserved. 欢迎转发分享及合理引用，引用时请在显要位置标明文章来源；如需转载，请给微信公众号后台留言或发送消息，并注明公众号名称及ID。 免责申明：本微信文章中的信息仅供一般参考之用，不可直接作为决策内容，医药魔方不对任何主体因使用本文内容而导致的任何损失承担责任。