预约演示
更新于：2025-07-19
Propafenone Hydrochloride
盐酸普罗帕酮
更新于：2025-07-19
概要
基本信息
药物类型 小分子化药 |
别名 1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-1-propanone、2-(2'-hydroxy-3'-propylaminopropoxy)-ω-phenylpropiophenone、Propafenone + [15] |
作用方式 阻滞剂 |
作用机制 钠通道阻滞剂 |
治疗领域 |
在研适应症 |
非在研适应症 |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 加拿大 (1988-01-01), |
最高研发阶段(中国)撤市 |
特殊审评- |
登录后查看时间轴
结构/序列
分子式C21H28ClNO3 |
InChIKeyXWIHRGFIPXWGEF-UHFFFAOYSA-N |
CAS号34183-22-7 |
关联
25
项与 盐酸普罗帕酮 相关的临床试验CTR20242812
盐酸普罗帕酮片人体生物等效性试验
NCT05939076
First-line Cryoablation for Early Treatment of Persistent Atrial Fibrillation - a Randomized Study Comparing Early Trigger Isolation Using the Cryoballoon Versus Antiarrhythmic Medication
NCT04508491
The Best Treatment Strategy for the Reservation of Cognitive Function in Patients With Persisted Atrial Fibrillation
100 项与 盐酸普罗帕酮 相关的临床结果
登录后查看更多信息
100 项与 盐酸普罗帕酮 相关的转化医学
登录后查看更多信息
100 项与 盐酸普罗帕酮 相关的专利（医药）
登录后查看更多信息
3,022
项与 盐酸普罗帕酮 相关的文献（医药）2025-11-01SEPARATION AND PURIFICATION TECHNOLOGY
Experimental characterization and QSAR modeling of maximum uptake and distribution factor for neutral and ionic micropollutants on granular activated carbon in artificial and real wastewaters
作者: Cho, Chul-Woong ; Park, Si-Hyeon ; Lee, Kwan-Yong ; Cho, Bo-Gyeon ; Jin, Se-Ra ; Cheon, Jeong-Min
Granular activated carbon (GAC)-based adsorption treatment for micropollutant removal is known to be cost-effective and environmentally sustainable.However, an efficient method is urgently needed to assess the applicability of GAC for a diverse range of micropollutants in various wastewater conditions.Therefore, we developed predictive models to determine the maximum uptake (qmax; calculated by the Langmuir model) and distribution factor (KF; calculated by the Freundlich model) of a range of micropollutants on GAC, which can help overcome exptl. limitations, save resources and time, and provide a deeper understanding of adsorption mechanisms.Exptl. isotherms for controlled conditions to obtain the qmax and KF were performed for both artificial and real wastewaters. qmax values of micropollutants were similar in both wastewaters, but KF values differed slightly.Exptl. obtained qmax and KF values were used in linear free energy relationship-based predictive modeling.The results showed reasonable predictive accuracy for qmax, with R2 values ranging from 0.844 to 0.875 and standard errors between 0.144 and 0.072 log units for both artificial and real wastewater conditions.For KF, the model showed R2 values between 0.803 and 0.762, with standard errors ranging from 0.189 to 0.163 log units.The two models showed high potential for use in GAC-based micropollutant removal.
2025-09-01BIOCHIMIE
Repurposing of propafenone, an FDA approved anti-arrhythmic drug for antileishmanial therapy
Article
作者: Singh, Sushma ; Paul, Anindita ; Khan, Mohd Faiz ; Babu, Neerupudi Kishore ; Lalchhuanawmi, Sandra ; Roy, Pradyot Kumar
Elimination of the Neglected Tropical Disease Visceral Leishmaniasis (VL) is a Sustainable Development Goal. It is caused by Leishmania donovani. The therapeutic options for the treatment of VL are limited due to problems such as drug resistance and toxicities. Drug repurposing can be a promising alternative in this case. In this work, the antileishmanial potential of FDA approved anti-arrhythmic drug propafenone has been evaluated for repurposing. It reduced the viability of L. donovani promastigotes and intracellular amastigotes with an IC50 of 8.25 ± 2.48 μM and 11.19 ± 0.01 μM respectively. In the macrophages, the IC50 was 32 ± 7.07 μM. Propafenone treatment altered morphology of parasites and induced damage to the body and flagellum. The cell membrane became damaged and more permeable when the promastigotes were treated with this drug. However, no change in the cell membrane potential was detected. Treatment with propafenone was detrimental to mitochondrial health of L. donovani. It significantly depolarized the mitochondrial membrane and decreased the ATP levels in the promastigotes. Propafenone also induced oxidative stress in the parasites. Cell cycle arrest was detected at the G2/M stage. The data suggests that propafenone has antileishmanial potential and can be evaluated further in an experimental VL model.
2025-07-01JOURNAL OF ELECTROCARDIOLOGY
Wide complex tachycardia and brugada electrocardiographic pattern induced by propafenone: A rare and unpredictable pro-arrhythmic effect
Article
作者: da Silva Rocha, Cynthia Aparecida ; Nikus, Kjell ; Pérez-Riera, Andrés Ricardo ; Martins, Luiz Claudio Behrmann ; Cardoso, Acácio Fernandes ; Pichara, Nemer Luiz
Propafenone is a class IC anti-arrhythmic drug used for the rhythm control strategy in atrial fibrillation worldwide, including in Latin America countries. Propafenone intoxication is a potentially life-threatening condition. Ventricular tachycardia and the Brugada electrocardiographic (ECG) pattern are possible pro-arrhythmic manifestations of propafenone poisoning. We present a rare patient case, where therapeutic range dosage of propafenone resulted in a wide complex tachycardia, followed by the Brugada ECG pattern during atrial fibrillation. We discuss the possible mechanisms related to this unusual ECG manifestation.
100 项与 盐酸普罗帕酮 相关的药物交易
登录后查看更多信息
研发状态
10 条最早获批的记录, 后查看更多信息
登录
| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 心房颤动 | 美国 | 1989-11-27 | |
| 心律失常 | 加拿大 | 1988-01-01 |
登录后查看更多信息
临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | - | 鏇壓醖餘窪願築齋衊衊(製網壓網憲壓製遞願簾) = 蓋願觸糧顧蓋醖願襯顧 夢繭獵觸鹽製壓觸鏇窪 (淵遞鹽襯鹽齋窪糧願顧 ) 更多 | - | 2024-04-09 | |||
鏇壓醖餘窪願築齋衊衊(製網壓網憲壓製遞願簾) = 繭顧選鹽醖範製廠淵築 夢繭獵觸鹽製壓觸鏇窪 (淵遞鹽襯鹽齋窪糧願顧 ) 更多 | |||||||
N/A | - | - | 鏇糧製觸夢構鑰膚廠艱(顧繭網鏇簾網襯構襯積) = 餘衊網醖觸觸膚範選夢 鹽壓艱製繭願構簾積鏇 (構築鹽築觸獵鏇窪糧鏇 ) | - | 2022-05-01 | ||
N/A | 60 | 淵壓觸製簾構觸壓鏇繭(淵淵簾積選願衊餘鹽簾) = 窪鬱壓鏇遞壓襯顧蓋壓 遞獵艱範鹹鏇鑰膚廠範 (鏇鹽構糧鑰醖觸顧築糧 ) | - | 2022-04-04 | |||
Aksaritmin | 淵壓觸製簾構觸壓鏇繭(淵淵簾積選願衊餘鹽簾) = 築獵築淵遞艱齋鹹鬱選 遞獵艱範鹹鏇鑰膚廠範 (鏇鹽構糧鑰醖觸顧築糧 ) | ||||||
N/A | 505 | Antazoline mesylate | 鹽壓窪範壓醖憲網築齋(製蓋襯遞壓構鏇觸觸夢) = 鹽選襯鏇廠壓範衊構製 觸襯鹽艱繭淵窪廠繭積 (鏇鏇襯醖壓獵構顧膚醖 ) | 积极 | 2019-09-01 | ||
鹽壓窪範壓醖憲網築齋(製蓋襯遞壓構鏇觸觸夢) = 齋獵衊膚蓋壓選選遞鬱 觸襯鹽艱繭淵窪廠繭積 (鏇鏇襯醖壓獵構顧膚醖 ) | |||||||
N/A | - | 62 | 窪鬱範鹹簾願築艱窪淵(繭衊獵餘鏇範製醖繭鏇) = 鹽獵簾網簾窪淵獵糧醖 憲鏇構鑰憲顧壓鬱簾製 (構積選餘餘鏇鬱簾簾積 ) | 积极 | 2019-07-01 | ||
窪鬱範鹹簾願築艱窪淵(繭衊獵餘鏇範製醖繭鏇) = 鑰鬱鹹遞夢夢積鏇鹹獵 憲鏇構鑰憲顧壓鬱簾製 (構積選餘餘鏇鬱簾簾積 ) | |||||||
N/A | 133 | Propafenone 450 mg/day | 鏇製齋鑰遞繭構蓋艱襯(淵衊齋觸淵壓鏇憲獵齋) = 糧鏇選鬱觸餘鬱選窪鹹 壓淵鑰鬱範餘廠範糧遞 (鏇淵網夢艱鹹範膚膚遞 ) 更多 | - | 2016-08-29 | ||
Sotalol (80-160 mg/day) | 餘鹽選鬱獵範構選簾鏇(膚繭鹹繭獵鬱鹹糧齋鑰) = 夢糧觸齋壓簾積獵簾夢 網夢鏇蓋夢構積鏇淵遞 (積築鹽簾範網網鹽餘構 ) | ||||||
N/A | 110 | Radiofrequency catheter ablation (AAD:NO) | 簾膚積淵淵窪願繭艱窪 = 範窪憲齋蓋襯願觸製鏇 膚鹹製網憲積獵夢鹽製 (窪願艱憲獵淵獵糧製鹹, 糧廠齋觸範淵觸顧簾獵 ~ 觸獵遞觸鬱膚觸鏇齋獵) 更多 | - | 2013-03-07 | ||
(AAD:YES) | 簾膚積淵淵窪願繭艱窪 = 壓構觸願淵簾淵糧齋構 膚鹹製網憲積獵夢鹽製 (窪願艱憲獵淵獵糧製鹹, 壓醖齋艱構壓製膚餘膚 ~ 鹽壓蓋夢襯範鹹夢繭顧) 更多 | ||||||
N/A | 60 | Ablation Therapy | 餘鹹廠襯窪餘淵鬱蓋鏇 = 鹽鬱築齋獵繭膚襯膚觸 願簾選窪鏇製餘餘積鑰 (鹹觸製蓋壓製遞構築鏇, 鹽窪膚鬱餘選憲鬱鬱夢 ~ 醖糧鏇膚範鏇範製選觸) 更多 | - | 2013-01-04 |
登录后查看更多信息
转化医学
使用我们的转化医学数据加速您的研究。
登录
或
药物交易
使用我们的药物交易数据加速您的研究。
登录
或
核心专利
使用我们的核心专利数据促进您的研究。
登录
或
临床分析
紧跟全球注册中心的最新临床试验。
登录
或
批准
利用最新的监管批准信息加速您的研究。
登录
或
特殊审评
只需点击几下即可了解关键药物信息。
登录
或
Eureka LS:
全新生物医药AI Agent 覆盖科研全链路，让突破性发现快人一步
立即开始免费试用!
智慧芽新药情报库是智慧芽专为生命科学人士构建的基于AI的创新药情报平台，助您全方位提升您的研发与决策效率。
立即开始数据试用!
智慧芽新药库数据也通过智慧芽数据服务平台，以API或者数据包形式对外开放，助您更加充分利用智慧芽新药情报信息。
生物序列数据库
生物药研发创新
免费使用
化学结构数据库
小分子化药研发创新
免费使用