预约演示
更新于：2026-05-07
Dabigatran Etexilate Mesylate
甲磺酸达比加群酯
更新于：2026-05-07
概要
基本信息
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C35H45N7O8S |
InChIKeyXETBXHPXHHOLOE-UHFFFAOYSA-N |
CAS号872728-81-9 |
关联
359
项与 甲磺酸达比加群酯 相关的临床试验NCT07515339
An Open-label Study to Investigate the Influence of Nurandociguat on the Pharmacokinetics of Rosuvastatin and Dabigatran in Healthy Participants
Researchers are looking for a better way to treat people who have chronic kidney disease. Chronic kidney disease (CKD) is a long-term condition where the kidneys do not work as well as they should. People with CKD are at a higher risk of heart and blood vessel problems and often need medicines to manage their health.
The study treatment nurandociguat (also called BAY 3283142) is a new medicine being developed to help people with CKD. It works by activating an enzyme called soluble guanylate cyclase (sGC), which helps relax blood vessels and may protect the kidneys. The study drug nurandociguat is thought to lower blood pressure and reduce kidney damage by improving blood flow and reducing stress on kidneys.
In this study, participants will be healthy and will not benefit from administration of nurandociguat. However, the study will provide information on how to test Nurandociguat in future studies in people with chronic kidney disease.
The main purpose of this study is to learn how safe nurandociguat is and how it affects the way the body processes (pharmacokinetics) two other medicines, rosuvastatin and dabigatran, in healthy adults.
For this, researchers will collect:
* the average highest level of rosuvastatin in the plasma (also called Cmax)
* the average highest level of dabigatran in the plasma (also called Cmax)
* the number of participants who have side effects during the study
There are 2 groups in this study, one for rosuvastatin and one for dabigatran. The study participants will be assigned to a group based on the study plan. Each group will have 2 periods: Period 1 and Period 2.
In period 1 a single dose of either rosuvastatin or dabigatran will be administered, and the breakdown of these 2 compounds will be investigated in the absence of nurandociguat.
In period 2, nurandociguat will be given for 7 days at a low dose, followed by a single high dose on Day 8. On Day 8, a single dose of rosuvastatin and dabigatran, will be also administered to investigate their breakdown by the human body in the presence of nurandociguat.
Each participant will be in the study for up to 7 weeks, including screening, treatment and follow up.
During the study, study doctors will:
* check vital signs (such as blood pressure and heart rate)
* perform physical exams
* take blood and urine samples for safety and to measure drug levels
* do electrocardiograms (ECGs)
* ask the participants questions about how they are feeling and what adverse events they are having
An adverse event is any medical problem that a participant has during a study. Doctors keep track of all adverse events, irrespective if they think it is related or not to the study treatment.
The study doctors and their team will contact the participant study to learn about the participant's health until the participant completes the study.
The study treatment nurandociguat (also called BAY 3283142) is a new medicine being developed to help people with CKD. It works by activating an enzyme called soluble guanylate cyclase (sGC), which helps relax blood vessels and may protect the kidneys. The study drug nurandociguat is thought to lower blood pressure and reduce kidney damage by improving blood flow and reducing stress on kidneys.
In this study, participants will be healthy and will not benefit from administration of nurandociguat. However, the study will provide information on how to test Nurandociguat in future studies in people with chronic kidney disease.
The main purpose of this study is to learn how safe nurandociguat is and how it affects the way the body processes (pharmacokinetics) two other medicines, rosuvastatin and dabigatran, in healthy adults.
For this, researchers will collect:
* the average highest level of rosuvastatin in the plasma (also called Cmax)
* the average highest level of dabigatran in the plasma (also called Cmax)
* the number of participants who have side effects during the study
There are 2 groups in this study, one for rosuvastatin and one for dabigatran. The study participants will be assigned to a group based on the study plan. Each group will have 2 periods: Period 1 and Period 2.
In period 1 a single dose of either rosuvastatin or dabigatran will be administered, and the breakdown of these 2 compounds will be investigated in the absence of nurandociguat.
In period 2, nurandociguat will be given for 7 days at a low dose, followed by a single high dose on Day 8. On Day 8, a single dose of rosuvastatin and dabigatran, will be also administered to investigate their breakdown by the human body in the presence of nurandociguat.
Each participant will be in the study for up to 7 weeks, including screening, treatment and follow up.
During the study, study doctors will:
* check vital signs (such as blood pressure and heart rate)
* perform physical exams
* take blood and urine samples for safety and to measure drug levels
* do electrocardiograms (ECGs)
* ask the participants questions about how they are feeling and what adverse events they are having
An adverse event is any medical problem that a participant has during a study. Doctors keep track of all adverse events, irrespective if they think it is related or not to the study treatment.
The study doctors and their team will contact the participant study to learn about the participant's health until the participant completes the study.
开始日期2026-04-08 |
申办/合作机构 |
NCT06650501
Dabigatran vs. Oral Anti-Xa Inhibitors in S. Aureus Bacteremia
This is an open-label randomized controlled trial which will enroll patients with S. aureus bacteremia who are already taking oral anticoagulant medications (apixaban, edoxaban, or rivaroxaban) for an approved indication (stroke prevention in atrial fibrillation, prevention or treatment of venous thromboembolism). We will randomize patients to continue their existing medication or change to another medication (dabigatran) which is approved for the original indication.
Dabigatran is approved in many countries for the treatment or prevention of venous thromboembolism or preventing stroke in atrial fibrillation. Unlike the other medications listed above, dabigatran seems to have activity against S. aureus in the test tube, in animal models, and in a smaller randomized controlled trial. We wish to determine if changing to dabigatran will improve outcomes in S. aureus bacteremia in people who otherwise would have a reason to be taking it.
This study is an approved sub-study of The Staphylococcus aureus Network Adaptive Platform (SNAP) trial (NCT05137119).
If positive, this study will support a second RCT in people who do not currently have an indication for anticoagulation.
Dabigatran is approved in many countries for the treatment or prevention of venous thromboembolism or preventing stroke in atrial fibrillation. Unlike the other medications listed above, dabigatran seems to have activity against S. aureus in the test tube, in animal models, and in a smaller randomized controlled trial. We wish to determine if changing to dabigatran will improve outcomes in S. aureus bacteremia in people who otherwise would have a reason to be taking it.
This study is an approved sub-study of The Staphylococcus aureus Network Adaptive Platform (SNAP) trial (NCT05137119).
If positive, this study will support a second RCT in people who do not currently have an indication for anticoagulation.
开始日期2026-01-15 |
申办/合作机构 |
CTIS2025-521362-10-00
Assessing the Efficacy of a Single Measurement and Adjustment Strategy for DOACs in Frail Older Patients: Insights from the DOAC-FRAIL RCT. A step towards safe(r) DOAC utilization in the frail older population.
开始日期2026-01-06 |
100 项与 甲磺酸达比加群酯 相关的临床结果
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100 项与 甲磺酸达比加群酯 相关的转化医学
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100 项与 甲磺酸达比加群酯 相关的专利（医药）
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5,476
项与 甲磺酸达比加群酯 相关的文献（医药）2026-07-01·BIOCHEMICAL PHARMACOLOGY
ABI3BP protects against cerebral ischemia-reperfusion injury by preserving blood-brain barrier integrity and activating PI3K/Akt signaling
Article
作者: Yin, Qi-Long ; Song, Wen-Jing ; Su, Rui-Qi ; Wen, Zhen-Fu ; Wang, Wan ; Qi, Su-Hua ; Huang, Lin-Yan ; Chen, Jie ; Zhang, Meng-Nan ; Qin, Zi-Lu ; Li, Li-Li ; Yang, Yi-Ci
Blood-brain barrier (BBB) disruption represents acritical pathological featurein the pathogenesis of stroke. The extracellular matrix plays acritical rolein preserving the structural and functional integrity of the BBB. ABI3BP, an extracellular matrix protein, participatesin stem cell proliferation and differentiation, cellular senescence, tumor suppression, and extracellular matrix remodeling. However, the function and mechanism of ABI3BP in cerebral ischemia-reperfusion injury (IRI) remain unclear. In this study, we found that ABI3BP mRNA increased while protein expression decreased in the ischemic cortex, and serum ABI3BP level rose post-IRI. The thrombin inhibitor dabigatran reverses the reduction of ABI3BP after I/R injury. Thrombin hydrolyzed ABI3BP at arginine 337. Recombinant ABI3BP crossed the BBB, reduced infarct volume, improved neurological scores, restored blood flow, and decreased BBB leakage by upregulating ZO-1/Occludin in ischemic brain tissue. ABI3BP inhibits the expression of cleaved caspase-3 and increases the expression of Bcl-2/Bax, p-Akt/Akt, and p-PI3K/PI3K in vivo and in vitro. IRI induced the hydrolysis and decrease of endogenous ABI3BP level. Supplementation of recombinant ABI3BP protects against cerebral IRI by preserving BBB integrity, enhancing tight junction proteins, and suppressing endothelial apoptosis via PI3K/Akt signaling. Conclusively, these findings suggest that ABI3BP protects BBB integrity, potentially by restoring tight junction protein expression and inhibiting endothelial cell apoptosis after IRI, which suggests its promise as a therapeutic agent in ischemic stroke.
2026-06-01·EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
In vitro inhibition of organic anion transporting polypeptide 2B1 (OATP2B1) is common among marketed drugs
Article
作者: Sjöstedt, Noora ; Sinokki, Alli ; Niemi, Mikko ; Kidron, Heidi ; Raza, Mohsin Ali ; Monnonen, Marju ; Neuvonen, Mikko
Organic anion transporting polypeptide 2B1 (OATP2B1) is a cell membrane influx transporter that may have a role in drug absorption and disposition. Inhibition of intestinal OATP2B1 has been suggested to decrease the oral bioavailability of some OATP2B1 substrate drugs potentially impairing their efficacy. This study aimed to identify uncharacterized OATP2B1 inhibitors among 228 commonly used drugs. For inhibition studies, OATP2B1 influx assays were performed with human embryonic kidney (HEK) 293 cells transduced with BacMam baculovirus containing the gene for SLCO2B1 (encoding OATP2B1) or enhanced yellow fluorescence protein (negative control). The drug library was screened at 50 µM at pH 6.0 with fluorescent 5-carboxyfluorescein as the OATP2B1 substrate. Out of the 228 drugs, 52 reduced the relative transport activity of OATP2B1 to less than 25 % of the control and were classified as strong in vitro inhibitors. Eleven selected strong inhibitors were advanced for dose-response studies to determine the concentration required for 50 % inhibition (IC50). The determined IC50 values ranged between 0.075-31 µM, with the most potent inhibitors being telmisartan (0.075 µM), dabrafenib (0.40 µM), and dabigatran etexilate (0.72 µM). Comparison of the predicted maximal intestinal concentrations of the drugs and the IC50 values showed ratios of >1000 for dabigatran etexilate, dabrafenib, pazopanib, sorafenib and telmisartan, suggesting that the risk of clinically significant drug-drug interactions cannot be excluded. Pharmacokinetic studies with victim drugs sensitive to OATP2B1 inhibition are warranted to investigate whether the found inhibitors inhibit OATP2B1 in vivo and cause drug-drug interactions in humans.
2026-05-01·EUROPEAN JOURNAL OF HAEMATOLOGY
Direct Oral Anticoagulants for Cancer‐Associated Venous Thromboembolism in Hematologic Malignancies: A Comprehensive Review
Review
作者: Fu, Leihua ; Chen, Zhe ; Feng, Weiying ; Xu, Chao ; Yu, Jieni ; Zhu, Yuli
ABSTRACT:
Venous thromboembolism presents a critical complication in hematologic malignancies, profoundly affecting patient outcomes. Traditional anticoagulant options, low‐molecular‐weight heparin and vitamin K antagonists, encounter significant limitations, especially concerning bleeding risks exacerbated by chemotherapy‐induced thrombocytopenia. Direct oral anticoagulants (DOACs), including factor Xa inhibitors (apixaban, rivaroxaban, edoxaban) and thrombin inhibitors (dabigatran), have emerged as appealing alternatives due to their ease of use, predictable pharmacokinetics, and reduced monitoring requirements. However, their safety and optimal use remain uncertain in hematologic malignancies due to underrepresentation in clinical trials and specific bleeding risks. This review comprehensively summarizes current evidence regarding DOAC safety, efficacy, and clinical management considerations in leukemia, lymphoma, multiple myeloma, and myeloproliferative neoplasms. It emphasizes individualized anticoagulation strategies, highlights existing evidence gaps, and outlines future research priorities, particularly the safe application of DOACs in severe thrombocytopenia and interactions with targeted therapies. Ultimately, tailored anticoagulant approaches are essential to optimizing patient outcomes in this complex patient population.
204
项与 甲磺酸达比加群酯 相关的新闻（医药）2026-04-30
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截至04月30日15点59分，近期共有 579 本期刊发布了 1148 篇文章，其中心血管相关的文章共 367 篇，覆盖 112 个领域的内容。中国专家参与发表的文章有 86 篇。今日，影响因子最高的文章刊登在 The New England Journal of Medicine (IF: 78.500) 期刊上。
高血脂
Hyperlipidemia
01 Nature IF: 48.500 餐后脂质代谢持久增强T细胞免疫
Kumar, Alok, Rivadeneira, Dayana B., Mehta, Isha, Xie, Bingxian, Cumberland, Rachel, Joshi, Supriya K., etc.
尽管内在代谢通路在T细胞功能中具有关键作用，但系统营养供应处于持续波动状态。然而，餐后代谢如何影响T细胞命运的研究尚不充分。本研究显示，个体的短期营养状态对T细胞免疫有显著影响。来自进食状态的人类或小鼠T细胞比禁食状态具有更高的代谢能力，且这种增强在体外或体内激活和扩增后持续存在。血清中富含**甘油三酯**的乳糜微粒是餐后免疫代谢重编程的驱动因素，乳糜微粒在离体条件下和激活后通过mTORC1依赖性翻译启动，显著增强了启动后的效应功能。来自同一供体的餐后人类CAR-T细胞相比禁食状态下采集的T细胞显示出治疗优势。因此，餐后代谢赋予T细胞持久的代谢和功能优势，强调了在免疫分析、疫苗接种和细胞治疗中考虑营养状态的重要性。
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Nature | Ahead of Print.
10.1038/s41586-026-10432-8
02 EJPC IF: 07.500 脂蛋白(a)对一级预防中冠状动脉粥样硬化斑块表型的影响
Verpalen, Victor A, Coerkamp, Casper F, Malkasian, Shant, Gaillard, Emilie L, Beverloo, Cheyenne Y Y, Ibrahim, Shirin, etc.
脂蛋白(a)是心血管事件的因果危险因素，但其对冠状动脉斑块组成和高危斑块特征的影响尚未完全明确。本研究旨在斑块水平上探讨Lp(a)与冠状动脉粥样硬化斑块表型的关联。
研究纳入710例于2008年至2024年间接受冠状动脉计算机断层扫描血管造影（CCTA）并测量Lp(a)的患者。CCTA扫描采用经先前验证的人工智能算法（AI-QCT, Cleerly Inc.）进行分析。在斑块水平上，使用广义估计方程模型评估Lp(a)与非钙化和钙化斑块体积以及高危斑块特征的关联，并校正传统心血管危险因素。
710例患者中，平均年龄56±10岁，男性379例（53%）。共识别出3642个斑块。在校正后的斑块水平分析中，Lp(a)升高（≥150 nmol/L）与每个斑块的非钙化斑块体积增加相关（P=0.009），但与钙化斑块体积增加无关（P=0.81）。此外，Lp(a)升高（≥150 nmol/L）与斑块水平上高危斑块的存在强相关（校正后比值比：1.78，95%置信区间：1.25-2.54，P=0.001），而低密度脂蛋白胆固醇和高敏C反应蛋白则无此关联（P>0.05）。
结论：在这项针对3642个单个斑块的斑块水平CCTA研究中，Lp(a)水平升高与非钙化斑块体积增加和高危斑块存在独立相关，但与钙化斑块体积无关。这些结果阐明了Lp(a)对不稳定斑块表型的影响，即使在无既往心血管事件的患者中也是如此。
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EJPC | Ahead of Print.
10.1093/eurjpc/zwag243
03 JAMA Cardiology IF: 14.100 基于低密度脂蛋白受体功能的家族性高胆固醇血症对前蛋白转化酶枯草溶菌素/kexin 9型抑制的反应：一项非随机临床试验
Frederick J. Raal, Nyda Fourie, Russell Scott, Dirk J. Blom, Matthys M. De Vries Basson, Meral Kayikcioglu, etc.
一项发表在JAMA Cardiology上的非随机临床试验评估了前蛋白转化酶枯草溶菌素/kexin 9型抑制剂lerodalcibep在杂合子家族性高胆固醇血症患者中的疗效，并探讨了低密度脂蛋白胆固醇降低是否依赖于低密度脂蛋白受体基因致病性变异的功能活性。该研究是对5项3期研究及开放标签扩展研究的预设汇总亚分析，共纳入703名杂合子家族性高胆固醇血症患者，平均年龄53.8岁，52.9%为男性，87.8%为白人。尽管大多数患者已接受他汀或依折麦布治疗，基线低密度脂蛋白胆固醇均值仍高达144.9 mg/dL。所有患者接受lerodalcibep 300 mg皮下注射每月一次，共72周。
结果显示，第48周和第72周低密度脂蛋白胆固醇平均降低均为50.3%，绝对降幅分别为72.6 mg/dL和71.8 mg/dL。在740名接受基因检测的患者中，61.5%发现单基因家族性高胆固醇血症致病性变异，其中95.7%为低密度脂蛋白受体变异。重要的是，低密度脂蛋白胆固醇降低幅度与低密度脂蛋白受体变异的功能活性无关，即无论变异导致受体功能缺失程度如何，疗效一致。超过70%的患者实现了低密度脂蛋白胆固醇降低至少50%并达到基于动脉粥样硬化性心血管疾病风险的目标值。
研究结论认为，lerodalcibep在杂合子家族性高胆固醇血症患者中显著且一致地降低低密度脂蛋白胆固醇，且反应独立于低密度脂蛋白受体致病性变异的功能。这支持了前蛋白转化酶枯草溶菌素/kexin 9型抑制主要通过上调未受影响的野生型低密度脂蛋白受体来降低低密度脂蛋白胆固醇的机制。
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JAMA Cardiology | Ahead of Print.
10.1001/jamacardio.2026.0879
04 Current Atherosclerosis Reports IF: 05.200 Obicetrapib引领CETP抑制剂复兴
Pirillo, Angela, Catapano, Alberico L., etc.
本综述探讨了胆固醇酯转移蛋白（CETP）抑制剂，特别是obicetrapib，在血脂管理中的新兴作用及其在动脉粥样硬化性心血管疾病（ASCVD）之外的潜在影响，包括神经退行性疾病、血糖控制、年龄相关性黄斑变性（AMD）、脓毒症和肾功能。
Obicetrapib是一种强效、选择性CETP抑制剂，克服了早期药物的局限性，能显著降低LDL-C、载脂蛋白B、非HDL-C和脂蛋白(a)，同时大幅升高HDL-C。2期和3期试验证实了其强大的调脂**有效性**和良好的安全性。新兴数据提示更广泛的生物学效应。遗传和机制研究将降低的CETP活性与改善的脑结构和较低的痴呆风险联系起来，生物标志物分析显示阿尔茨海默病相关标志物减弱，尤其在APOE ε4携带者中。证据还表明潜在的代谢获益，包括降低2型糖尿病风险和改善血糖控制。虽然遗传研究对AMD风险增加提出担忧，但临床试验数据未证实这一关联。临床前和人类数据提示通过HDL介导的内毒素清除在脓毒症中发挥保护作用，早期分析表明可能通过减缓肾功能下降带来肾脏获益。
Obicetrapib代表了CETP抑制领域的一个有前景的进展，结合了强效降脂作用和良好的安全性。除了降低心血管风险，新兴证据支持其在神经退行性疾病、代谢调节、感染结局和肾功能方面的潜在作用。正在进行中的结局试验将确定其临床影响和更广泛的治疗相关性。
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Current Atherosclerosis Reports | Volume 28, Issue 1, Page 1- 2
10.1007/s11883-026-01416-0
高血压
Hypertension
01 J Matern Fetal Neonatal Med IF: 01.600 妊娠间隔与妊娠期高血压疾病的关系：一项回顾性队列研究
Luo, Mei, Wang, Yingjun, Wang, Yanan, Zhao, Juan, Gao, Jie, etc.
一项发表在《The Journal of Maternal-Fetal & Neonatal Medicine》上的回顾性队列研究探讨了妊娠间隔（IPI）与妊娠期高血压疾病（HDP）风险之间的关联，并评估了母体基线特征是否修饰这一关联。研究纳入了2014年至2023年间在单一中心有至少两次连续单胎分娩的1633名女性。IPI作为连续变量纳入回归分析，采用修正泊松回归估计HDP和子痫前期的风险比（RR）及95%置信区间（CI）。
结果显示，在充分调整混杂因素后，较长IPI与HDP风险轻度但统计学显著增加相关（调整后RR=1.009/月，95%CI:1.001-1.017，p=0.024）。然而，IPI与子痫前期之间未观察到显著关联（所有p>0.05）。进一步分析发现，IPI与既往HDP状态存在显著交互作用（交互作用p=0.023）。在10.3%有HDP病史的女性中，IPI与HDP风险无显著关联；而在无HDP病史的女性中，较长IPI与HDP风险增加相关（调整后RR=1.017，p=0.005）。母体年龄和孕前BMI未显示显著交互作用。敏感性分析在多种场景下（包括额外调整阿司匹林使用）均得出一致结果。
研究结论指出，较长IPI独立与HDP风险轻度增加相关，尤其对于无HDP病史的女性。IPI与子痫前期无显著关联，提示IPI可能主要影响广义的HDP表型而非特定亚型。这些发现支持在孕前咨询中考虑IPI，并强调个体化风险评估的重要性。
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J Matern Fetal Neonatal Med | Volume 39, Issue 1
10.1080/14767058.2026.2661436
02 Hypertension IF: 08.200 肱动脉与中心动脉动态血压与死亡率的关系
De-Wei An, Ying Wang, Yi-Bang Cheng, Dong-Yan Zhang, Qi-Fang Huang, Ren-Zhi Cai, etc.
一项基于上海瑞金动态血压监测登记处的大规模队列研究，纳入36,594名门诊患者（中位年龄53.4岁，52.8%女性），旨在比较24小时动态监测的肱动脉收缩压与中心动脉收缩压对总死亡率和心血管死亡率的预测价值。
研究使用Mobil-O-Graph设备进行24小时动态血压监测，中心动脉收缩压采用两种校准方法：基于肱动脉收缩压和舒张压（C1校准）以及基于平均动脉压和肱动脉舒张压（C2校准）。中位随访4.0年期间，共发生505例死亡，其中174例死于心血管疾病。
多变量调整后的Cox回归分析显示，每1个标准差增加的标准化风险比：对于总死亡率，肱动脉收缩压为1.14（95% CI 1.05-1.24），中心动脉收缩压C1为1.10（1.01-1.20），C2为1.13（1.04-1.23）；对于心血管死亡率，相应风险比分别为1.33（1.14-1.55）、1.26（1.07-1.50）和1.33（1.15-1.55）。非线性模型拟合优于线性模型（P<0.001）。
在基础模型（包括性别、体重指数、24小时脉率、当前吸烟、血脂异常、糖尿病、心血管病史和降压药使用）上加入任何24小时收缩压均提高了C统计量（P=0.003-0.06），但在已包含肱动脉收缩压的模型基础上再加入中心动脉收缩压（C1或C2）并未显著提高C统计量（P=0.054-0.22）。
研究结论认为，中心动脉收缩压相比肱动脉收缩压并未改善与死亡率的关联，动态肱动脉收缩压测量足以用于基于血压的风险分层。
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Hypertension | Ahead of Print.
10.1161/HYPERTENSIONAHA.126.26778
03 AHJ Plus: Cardiology Research & Practice IF: 01.800 家庭血压监测与老年高血压患者跌倒风险：AMBROSIA-HOME研究
Bharat Poudel, Zhixin Wang, Daichi Shimbo, Joseph E. Schwartz, Kristi Reynolds, Teresa N. Harrison, etc.
一项名为AMBROSIA-HOME的研究探讨了家庭血压监测与老年高血压患者跌倒风险之间的关系。该研究纳入541名年龄≥65岁且正在服用降压药物的参与者，平均年龄74.2岁，女性占57.3%，前衰弱和衰弱患病率分别为50.7%和3.4%。参与者接受正确的家庭血压监测技术指导，并连续7天每天早晚各测量2次血压。在499名拥有至少4天家庭血压监测数据的参与者中，白大衣效应被定义为诊室血压均值减去家庭血压均值，日间变异性则通过标准差独立于均值计算。参与者每月报告跌倒情况，持续1年。在379人-年的随访期间，共有187名参与者报告跌倒。分析结果显示，家庭血压监测的平均收缩压、白大衣效应和日间变异性的最高与最低四分位数相比，跌倒的风险比分别为0.85（95%置信区间0.53-1.37）、0.84（0.51-1.40）和0.97（0.62-1.51），均无统计学显著差异。此外，舒张压的相关指标与跌倒风险之间也未发现关联。研究结论指出，在接受治疗的老年美国高血压患者中，通过家庭血压监测测量的血压值与跌倒风险无关。
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AHJ Plus: Cardiology Research & Practice | Ahead of Print.
10.1016/j.ahjo.2026.100791
高血糖
Diabetes Mellitus
01 Wound repair and regeneration IF: 03.400 糖尿病足溃疡住院后30天再入院：一项全国性分析
Sanaka, Krishna O, Mitra, Nandita, Margolis, David J, etc.
糖尿病足溃疡是糖尿病成人住院的常见原因，与高发病率和死亡率相关。住院后再入院仍然常见，但描述再入院模式和驱动因素的全国代表性证据有限。
这项回顾性队列研究使用了2022年美国全国再入院数据库，旨在描述30天全因再入院率，识别与再入院相关的因素，并比较美国糖尿病足溃疡住院成人的指标住院和再入院情况。通过诊断代码识别诊断为糖尿病足溃疡的成人住院，并进行调查加权分析以生成全国估计。
在估计的234,797次初始住院中，13.3%的患者在30天内再入院，超过了全国住院患者平均水平8.2%。再入院患者中肾脏疾病、心血管疾病和精神健康状况的患病率更高。多变量分析显示，肾脏疾病、心血管合并症、烟草使用、药物使用障碍和双相情感障碍与再入院风险增加相关。相反，初始住院期间的感染相关诊断和手术，包括骨感染、手术清创和下肢截肢，与再入院风险降低相关。再入院住院时间更长，急性全身性疾病患病率更高。
这些发现表明，糖尿病足溃疡住院后早期再入院主要由全身性医疗不稳定驱动，而非局部感染复发，强调了多学科住院和出院后护理策略的必要性。
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Wound repair and regeneration | Volume 34, Issue 3
10.1111/wrr.70165
02 Journal of diabetes IF: 03.700 糖尿病神经病变的人口统计学和临床特征：来自2012-2017年韩国国民健康保险服务的数据
Jeong, Su Jin, Kim, Sun Keun, Kim, Chong Hwa, etc.
糖尿病神经病变（DN）是2型糖尿病（T2DM）最常见的慢性并发症，既往研究报告的患病率在23%至54.5%之间。本研究利用韩国国民健康保险服务（NHIS）2012年至2017年的数据，评估了DN的患病率、临床特征及治疗情况。
研究分析了NHIS样本数据中870万按年龄、性别、资格和收入分层的人群。DN的定义采用ICD-10编码（E10.4-E14.4, G59.0, G63.2, G99.0）以及同时开具糖尿病和DN处方的标准。计算了糖尿病患者中每年的DN患病率，并比较了有和无DN患者的治疗模式及患者特征。
结果显示，DN患病率从2012年的23.4%下降至2017年的21.5%。约半数DN患者接受了药物治疗，其中单药治疗比例高达82%，二联治疗占15%，三联治疗占3%。最常处方的药物是α-硫辛酸（52.1%-55.0%），其次是抗惊厥药（30.4%-34.5%）、三环类抗抑郁药、SNRIs和γ-亚麻酸。DN患者通常年龄较大，女性居多，且合并症更多，如高血压、血脂异常、心血管疾病、糖尿病足和截肢。他们更可能使用胰岛素或多种口服降糖药。
结论指出，约四分之一的T2DM患者患有DN，其中半数接受了治疗，主要为α-硫辛酸单药治疗。DN患者往往年龄较大且合并多种疾病，导致住院率更高。
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Journal of diabetes | Volume 18, Issue 5
10.1111/1753-0407.70196
03 JAMA dermatology IF: 11.000 美国国家银屑病基金会关于GLP-1受体激动剂治疗银屑病的入门指南：综述
Samip Sheth, Joseph F. Merola, Brittany N. Weber, Ronald Prussick, Jensen Yeung, Clive Liu, etc.
美国国家银屑病基金会医学委员会近日在《JAMA dermatology》上发表了一篇综述，为皮肤科医生介绍了GLP-1受体激动剂（GLP-1 RAs）在银屑病治疗中的应用。
银屑病是一种慢性免疫介导疾病，常伴有心血管、代谢、肌肉骨骼、精神、肝脏、肾脏和肺部共病。GLP-1 RAs已获美国食品药品监督管理局批准用于2型糖尿病、肥胖、心血管风险降低、慢性肾脏病、阻塞性睡眠呼吸暂停和代谢功能障碍相关脂肪性肝炎，这些疾病在银屑病患者中常见。新出现的证据表明，GLP-1 RAs和双重葡萄糖依赖性促胰岛素多肽/GLP-1激动剂可能通过免疫调节改善银屑病皮损。如果在大规模随机临床试验中得到证实，基于GLP-1的疗法可能为同时治疗皮肤疾病和心血管代谢共病提供机会。
综述的观察部分指出，GLP-1 RAs与银屑病面积和严重程度指数（PASI）评分降低相关，尤其在肥胖或2型糖尿病患者中。研究报告PASI相对降低约40%至80%，同时生活质量改善，但大多数研究规模较小（7-48例患者）、短期（≤6个月）且缺乏对照组。司美格鲁肽和利拉鲁肽与C反应蛋白、白细胞介素-6、血脂和内脏脂肪减少相关。在小型转化队列中，PASI改善与浅表脂肪和真皮γδ T细胞密度减少相关。GLP-1 RAs可与甲氨蝶呤、环孢素和生物制剂安全联用。不良反应主要为短暂胃肠道症状，胰腺炎和胆囊事件罕见。早期数据显示代谢和免疫调节双重益处。
综述结论认为，基于GLP-1的疗法靶向银屑病中共享的代谢和炎症通路。当前证据支持在选定的代谢共病患者中考虑辅助使用，但最终结论尚需更大规模随机临床试验证实。
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JAMA dermatology | Ahead of Print.
10.1001/jamadermatol.2026.0859
04 Frontiers in endocrinology IF: 04.600 糖尿病视网膜病变与焦虑和抑郁的双向关系：一项荟萃分析
Fan, Seng, Gai, Ziyue, Ma, Hui, Wen, Ziye, Ma, Chunlei, Fan, Dongying, etc.
一项发表于《Frontiers in Endocrinology》的荟萃分析系统评估了糖尿病视网膜病变（DR）与焦虑、抑郁之间的双向关系。研究共纳入34项观察性研究，涉及383,195例患者，覆盖14个国家。
结果显示，DR患者发生抑郁的风险显著高于非DR患者（OR=1.58，95%CI:1.24-2.02，P<0.001）；反之，抑郁患者发生DR的风险也显著升高（OR=2.13，95%CI:1.53-2.98，P<0.001），提示两者存在双向关系。此外，DR患者发生焦虑的风险是非DR患者的2.23倍（95%CI:1.07-4.68，P=0.033）。
亚组分析表明，研究设计、地区和混杂因素可能是异质性的来源。敏感性分析显示结果总体稳健，但存在发表偏倚。
研究建议，在DR的临床治疗中应重视患者的心理状态，实施个性化心理护理，以改善患者预后。
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Frontiers in endocrinology | Volume 17, Issue
10.3389/fendo.2026.1764745
心房颤动
Atrial Fibrillation
01 Heart Rhythm IF: 05.700 房颤导管消融术后心律失常复发的临床危险因素识别：系统评价与荟萃分析
Kimmy W.P. Chan, Doris S.F. Yu, Joshua W.K. Ho, Cathy W.Y. Wong, Polly W.C. Li, etc.
一项发表于《Heart Rhythm》的系统评价与荟萃分析系统评估了房颤导管消融术后心律失常复发的临床危险因素。研究检索了八个数据库，纳入截至2025年12月31日的前瞻性队列研究，最终纳入152项研究，共49,919例患者。研究质量采用纽卡斯尔-渥太华量表评价，并通过随机效应模型合并多变量校正风险比（aHR）。
在主要荟萃分析中，共识别出16个临床危险因素。与术后复发关联最强的危险因素包括吸烟（aHR: 2.15）、牙周炎（aHR: 2.04）、代谢综合征（aHR: 1.71）、睡眠呼吸暂停（aHR: 1.65）和持续性房颤（aHR: 1.64）。其他显著危险因素包括慢性肾脏病、饮酒、超重/肥胖、糖尿病、女性、高血压、房颤病史、左心房增大和左心室射血分数降低。
进一步分析显示，未经治疗的睡眠呼吸暂停（aHR: 2.41）和未控制的高血压（aHR: 1.67）与更高的复发风险相关。敏感性分析合并校正比值比（aOR）后，还识别出抑郁（aOR: 2.86）和焦虑（aOR: 2.54）为额外危险因素。
亚组分析表明，这些危险因素在不同房颤表型（阵发性、持续性等）间效应一致。荟萃回归分析发现，消融方式对房颤病史与复发风险的关联有显著调节作用，而地理区域对女性、心力衰竭和糖尿病与复发风险的关联有调节作用。
研究结论认为，扩展的术前危险因素谱在不同房颤表型中效应一致，支持对消融候选者进行个体化风险分层和术前优化。
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Heart Rhythm | Ahead of Print.
10.1016/j.hrthm.2026.04.046
02 J Comp Eff Res IF: 02.500 脉冲场消融与传统热消融治疗中国阵发性房颤患者的卫生经济学分析
Ye, Jian, Fan, Youqi, Wang, Ye, Jian, Yifei, Gao, Yue, Chen, Shuting, etc.
一项发表于《Journal of Comparative Effectiveness Research》的研究评估了脉冲场消融（PFA）与射频消融（RFA）和冷冻消融在中国阵发性房颤患者中的成本效用。研究从医疗视角出发，构建决策树模型，模拟不同房性心律失常负荷（<0.1%、0.1-9.9%、≥10%）患者消融后的状态变化，包括重复消融或非致命性卒中。转移概率、临床结局和生活质量数据来自已发表文献并经专家确认，成本数据基于三级医院临床实践调查。
结果显示，在中国三倍人均GDP阈值下，PFA相比RFA和冷冻消融均具有成本效果。与RFA相比，PFA增加0.016个质量调整生命年（QALYs）（0.859 vs 0.842），增量成本效果比（ICER）为¥37,000/QALY，主要节省来自重复消融手术费用（¥1558）和长期抗心律失常及抗凝药物费用（¥506）。与冷冻消融相比，PFA增加0.006个QALYs（0.859 vs 0.852），ICER为¥231,167/QALY，主要节省来自重复消融手术费用（¥1300）和长期药物费用（¥133）。
次要结局从医院管理者视角计算投资回报率，PFA的投资回报率为0.313。研究结论认为，PFA在中国可能比RFA和冷冻消融更具成本效果，是一种高价值干预，既能带来优越的临床结局，又能维持医院财务可持续性，支持其在房颤管理中的优先采用。
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J Comp Eff Res | Ahead of Print.
10.57264/cer-2025-0153
03 FCVM IF: 02.900 心房颤动患者右束支传导阻滞的患病率及其对消融后复发的影响
Chu, Huimin, Wang, Binhao, Wang, Xiaojie, Yang, Yiheng, Han, Xu, Yang, Xiaolei, etc.
一项发表在《Frontiers in Cardiovascular Medicine》上的回顾性研究探讨了心房颤动患者中右束支传导阻滞的患病率及其对射频消融后复发的影响。研究纳入2018年至2020年间在单一中心接受首次射频消融的949例心房颤动患者，根据术前心电图分为非RBBB组（857例）、不完全性右束支传导阻滞（IRBBB）组（42例）和完全性右束支传导阻滞（CRBBB）组（50例）。
结果显示，CRBBB和IRBBB的患病率分别为5.3%和4.4%，且均随年龄增长而显著增加（p<0.001）。IRBBB在男性中更常见（5.8% vs 2.4%, p=0.011）。基线特征方面，CRBBB组患者年龄更大、心衰比例更高、心房内径更大、左室射血分数略低；IRBBB组男性比例更高、阵发性心房颤动比例较低、左房内径较大。
中位随访790天后，非RBBB组、IRBBB组和CRBBB组的复发率分别为32.2%、23.8%和56.0%。Kaplan-Meier分析显示三组窦律维持率差异有统计学意义（p=0.006）。多因素Cox回归分析表明，CRBBB是射频消融后复发的独立预测因子（HR=1.83, 95%CI: 1.04-3.23, p=0.037），而IRBBB与复发无显著关联。竞争风险模型结果一致。
研究讨论指出，CRBBB可能通过导致心室不同步、右室功能障碍、心房纤维化及非肺静脉触发灶形成等机制增加复发风险。临床实践中，合并CRBBB的心房颤动患者术前评估应更全面，尤其是存在结构性心脏病因素时。该研究为单中心回顾性设计，样本量有限，需前瞻性多中心研究验证。
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FCVM | Volume 13, Issue
10.3389/fcvm.2026.1790398
结构性心脏病
Structural Heart Disease
01 Heart Rhythm IF: 05.700 经导管三尖瓣介入时代中导线管理的重要性
Nicholas J. Beccarino, Aditya Goyal, Zachary Ostreicher, James K. Gabriels, Moussa Saleh, Elana Koss, etc.
经导管三尖瓣介入治疗（如经导管三尖瓣置换术TTVR和经导管缘对缘修复tTEER）已成为严重三尖瓣反流（TR）的有效治疗手段。然而，当患者体内存在经静脉导线（如起搏器或除颤器导线）时，TR的管理变得复杂，需要多学科团队协作。经静脉导线拔除（TLE）可能改善或加重导线相关的TR，并且在考虑TTVR时至关重要，以避免导线被“囚禁”在经导管瓣膜与原生三尖瓣之间。目前关于此类情况的数据和指导有限。
本研究旨在描述一种策略的结局，即对严重TR且导线跨越三尖瓣、正在考虑经导管三尖瓣介入（TTVR或tTEER）的患者实施TLE。研究纳入了2020年7月至2025年7月期间在一个高容量拔除中心因TR接受TLE的所有患者，共24例，其中14例（58.3%）为女性，平均年龄73.7岁。所有患者均患有严重TR并存在经静脉导线。
结果显示，所有患者均实现了完全TLE手术成功。11例患者（46%）在拔除导线后TR程度减轻，其中8例（33%）因此无需进一步的三尖瓣介入治疗。在其余需要介入的患者中，12例（75%）成功接受了后续的三尖瓣介入治疗（TTVR或tTEER）。研究期间共有3例死亡，但均与手术无关。
结论指出，在本系列中，TLE是一种安全有效的方法，可以减轻TR程度，或作为后续三尖瓣介入治疗的桥梁。
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Heart Rhythm | Ahead of Print.
10.1016/j.hrthm.2026.04.045
02 JAMA Cardiology IF: 14.100 医疗保险人群中转甲状腺素蛋白心脏淀粉样变性诊断的及时性
Gabriela Spencer-Bonilla, Jun Fan, Paul Cheng, Natasha Din, Fatima Rodriguez, Marie Davies, etc.
一项发表在JAMA Cardiology上的研究利用美国Medicare fee-for-service数据，分析了2016年至2022年间7770例同时患有心力衰竭和转甲状腺素蛋白心脏淀粉样变性（ATTR-CM）的患者，评估了从心衰诊断到ATTR-CM诊断的时间延迟及其相关因素。
研究显示，患者确诊ATTR-CM时的中位年龄为81岁，其中77%为男性。从心衰诊断到ATTR-CM诊断的中位时间为494天（约16个月），四分位距为63至1340天。对于6175例在ATTR-CM诊断前曾使用袢利尿剂的患者，从首次袢利尿剂处方到ATTR-CM诊断的中位时间更长，达840天（约28个月）。
多变量逻辑回归分析发现，高龄（OR 0.68）、房颤病史（OR 0.39）和腕管综合征（OR 0.85）与较低的延迟诊断风险相关。而女性（OR 1.28）、主动脉瓣狭窄（OR 1.39）、慢性阻塞性肺疾病（OR 1.18）、冠心病（OR 1.26）、糖尿病（OR 1.21）和高血压（OR 1.28）则与较高的延迟诊断风险相关。
研究结论指出，心衰患者中ATTR-CM的诊断存在显著延迟，尤其对于女性以及合并主动脉瓣狭窄、冠心病、糖尿病、高血压或慢性阻塞性肺疾病的患者，这些疾病本身也与心肌病和呼吸困难相关。因此，临床医生应提高对这类患者中ATTR-CM的怀疑指数。
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JAMA Cardiology | Ahead of Print.
10.1001/jamacardio.2026.0833
03 JAHA IF: 05.300 经导管缘对缘修复三尖瓣反流对右心室血流动力学的急性影响
Jan‐Christian Reil, Paul Steendijk, Vasco Sequeira, Johanna Bormann, Anna Klinke, Gert‐Hinrich Reil, etc.
经导管缘对缘修复是治疗重度三尖瓣反流的既定疗法，但其对右心室力学的急性影响尚不完全清楚。本研究旨在通过有创压力-容积分析量化经导管缘对缘修复对右心室功能的急性血流动力学效应。
研究纳入9例重度三尖瓣反流（III-IV级）患者，同时进行有创和超声心动图评估右心室功能。在右心室内放置7电极电导导管连续记录压力-容积信号，并校准于三维超声心动图右心室容积。在手术前后获取稳态右心室压力-容积环和超声心动图。
结果显示，经导管缘对缘修复显著减少了反流容积。前向每搏量显著增加（41 [34-48] vs 51 [43-57] mL，P=0.004），尽管右心室后负荷和收缩力保持不变（收缩末期弹性0.33 [0.24-0.53] vs 0.32 [0.25-0.72] mm Hg/mL，P=0.30）。每搏功得以保留。前负荷降低（右心室舒张末期容积145 [113-171] vs 131 [104-137] mL，P=0.01；右心室舒张末期压力9 [6-11] vs 7 [4-9] mm Hg，P=0.03），反映了显著的右心室负荷减轻。
结论认为，成功的经导管缘对缘修复伴随心肌工作经济化，通过将血流重新导向肺循环实现。前向每搏量增加，而收缩力和每搏功保持不变。前负荷显著降低，提示前负荷储备改善。
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JAHA | Ahead of Print.
10.1161/JAHA.125.047560
04 Structural Heart IF: 02.800 功能性二尖瓣反流经导管缘对缘修复结局的性别与种族差异：一项多中心前瞻性分析
Park, Kyeeun, Stebbins, Amanda, Han, Sunwoo, Manandhar, Pratik, Pahuja, Karan, Aung, Pyi Phyo, etc.
一项多中心前瞻性分析利用STS/ACC TVT注册研究数据，评估了性别和种族对功能性二尖瓣反流（FMR）患者接受经导管缘对缘修复（经导管缘对缘修复）结局的影响。研究纳入2013年11月至2021年12月期间因FMR行TEER的9441例患者，其中57.4%为男性，80.4%为白人，16.3%为黑人，2.7%为亚洲人。
结果显示，黑人患者较白人更年轻，左室射血分数（LVEF）更低，左室尺寸更大。黑人患者30天手术成功率显著低于白人（48.9% vs 57.0%），主要由于术后二尖瓣梯度升高比例更高。调整后，黑人患者12个月心衰再住院风险比白人高35%（aHR 1.35）。亚洲患者结局与白人相当。
女性患者基线LVEF较高、左室较小，但30天手术成功率低于男性（48.1% vs 61.3%），同样与二尖瓣跨瓣压差升高相关。女性30天全因再住院率和心衰再住院率也较高，但调整后1年结局与男性无显著差异。
研究还发现，TEER术后总体院内并发症罕见，30天死亡率为4.1%，12个月心衰再住院率约18.6%-18.8%，较术前62.5%显著下降。COAPT试验后，TEER手术量增加8.7倍，黑人患者比例从12.2%升至17.1%。
研究结论指出，种族和性别差异在TEER结局中显著存在。黑人患者疾病更晚期，手术成功率低且心衰再住院风险高；女性患者手术成功率低但长期调整后结局与男性相似。需要针对性策略和结构性改革来改善所有FMR患者的预后。
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Structural Heart | Volume 10, Issue 5
10.1016/j.shj.2026.100831
抗凝
Anticoagulantion
01 J Gen Intern Med IF: 04.200 维生素K拮抗剂或直接口服抗凝药物治疗中胃肠道出血的严重程度
Christiansen, Christine Benn, Henriksen, Nadia A, Burcharth, Jakob, Lamberts, Morten, Fosbøl, Emil, Butt, Jawad Haider, etc.
一项基于丹麦全国注册的研究比较了维生素K拮抗剂与直接口服抗凝药物在房颤患者中引起胃肠道出血的严重程度。研究纳入2012年至2018年间6784例接受抗凝治疗并发生胃肠道出血的房颤患者，其中3724例使用维生素K拮抗剂，3060例使用直接口服抗凝药物（包括阿哌沙班、达比加群和利伐沙班）。
结果显示，维生素K拮抗剂组上消化道出血比例为49%，直接口服抗凝药物组为40.1%。维生素K拮抗剂组输血比例为58.2%，直接口服抗凝药物组为43.8%至48.9%。经年龄、性别和合并症校正后，与维生素K拮抗剂相比，所有直接口服抗凝药物均与严重出血风险显著降低相关：阿哌沙班比值比为0.71（95%置信区间0.59-0.85），达比加群为0.64（95%置信区间0.55-0.75），利伐沙班为0.69（95%置信区间0.59-0.81）。
在内镜检查方面，与维生素K拮抗剂相比，阿哌沙班和达比加群的内镜检查风险显著降低，比值比分别为0.77（95%置信区间0.65-0.90）和0.81（95%置信区间0.71-0.93），利伐沙班边缘显著（比值比0.88，95%置信区间0.77-1.02）。在上消化道出血患者中，与维生素K拮抗剂相比，阿哌沙班的胃镜检查风险显著降低（比值比0.68，95%置信区间0.53-0.87），而达比加群和利伐沙班无显著差异。
研究结论认为，维生素K拮抗剂的使用与更严重的胃肠道出血和更频繁的内镜检查相关，而直接口服抗凝药物则显示出更好的安全性。未来研究应识别特别容易发生严重出血的亚组。
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J Gen Intern Med | Ahead of Print.
10.1007/s11606-026-10425-3
02 JAHA IF: 05.300 心房颤动中的冠状动脉栓塞：一种在抗凝治疗下仍存在残余血栓栓塞风险的高危表型
Jinsong Cheng, Hengyi MaoMCM, Minfang Guan, Hanbin Cui, etc.
一项发表在《Journal of the American Heart Association》上的回顾性队列研究揭示了心房颤动患者中冠状动脉栓塞作为一种高危表型的临床特征。研究利用中国一家三级医院2014年至2023年的电子健康记录和区域死亡登记数据，在4777例急性心肌梗死患者中，通过改良Shibata标准、盲法造影核心实验室评估和最终裁定三阶段验证，诊断出78例冠状动脉栓塞合并心房颤动患者。
结果显示，冠状动脉栓塞占所有急性心肌梗死病例的1.6%（95% CI, 1.3%-2.0%），在心房颤动相关的急性心肌梗死中占14.7%至27.6%。与无心房颤动的非冠状动脉栓塞急性心肌梗死患者相比，冠状动脉栓塞合并心房颤动患者的全因死亡风险显著升高（重叠加权风险比1.77，95% CI, 1.15-2.71），缺血性卒中风险也显著升高（重叠加权风险比4.45，95% CI, 2.34-8.45）。值得注意的是，尽管79.2%的患者接受了治疗性抗凝治疗，仍观察到较高的残余血栓栓塞风险。
研究结论指出，冠状动脉栓塞合并心房颤动是一种高危表型，即使在抗凝治疗下仍存在高残余血栓栓塞风险。研究者提出了一种综合管理策略，包括多模态影像学检查、栓塞靶向再灌注治疗以及优化抗栓治疗（如标准剂量直接口服抗凝药），为未来的临床研究提供了方向。该研究已在ClinicalTrials.gov注册（NCT06845956）。
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JAHA | Ahead of Print.
10.1161/JAHA.125.045749
中国发表（86）
China
Scientific reports IF: 03.900Ahead of Print.No.01A multi-omics study revealed regulatory mechanism landscape of high-altitude congenital heart disease in Tibetan female patients多组学研究揭示藏族女性高海拔先天性心脏病的调控机制全景DOI: 10.1038/s41598-026-51079-9
Journal of clinical anesthesia IF: 05.100Ahead of Print.No.02Supraclavicular coronal oblique plane view and rainbow sign: A novel ultrasound technique for real-time detection and correction of guidewire misplacement during subclavian vein catheterization锁骨上冠状斜切面与彩虹征：一种用于锁骨下静脉置管时实时检测和纠正导丝误置的新型超声技术DOI: 10.1016/j.jclinane.2026.112216
Int J Antimicrob Agents IF: 04.600Ahead of Print.No.03Risk factors and serum concentration thresholds associated with tigecycline-induced hepatotoxicity in critically ill patients危重症患者替加环素相关肝毒性的危险因素及血清浓度阈值DOI: 10.1016/j.ijantimicag.2026.107822
......
其他发布内容（268）
Others
BMJ case reports IF: 00.500Volume 19, Issue 4No.01Dapsone-induced methaemoglobinaemia: a challenging diagnosis or missed opportunity? Exploring human factors in the diagnostic process氨苯砜诱导的高铁血红蛋白血症：诊断挑战还是错失良机？探索诊断过程中的人为因素DOI: 10.1136/bcr-2025-271307
JCMR IF: 06.100Ahead of Print.No.02Fontan Conduit Cross-sectional Area and Relationship to Exercise PerformanceFontan管道横截面积与运动表现的关系DOI: 10.1016/j.jocmr.2026.102729
JVS-Vascular Science IF: 02.000Ahead of Print.No.03Rapid responses of catecholamines, natriuretic peptides and inflammatory markers to acute type B Aortic Dissection (NOMAD Study)急性B型主动脉夹层中儿茶酚胺、利钠肽和炎症标志物的快速反应（NOMAD研究）DOI: 10.1016/j.jvssci.2026.100422
......
67
Hypertension
高血压
44
Heart Failure(HF)
心力衰竭
33
Atrial Fibrillation(AF)
心房颤动
32
Arrhythmias
心律失常
32
Triglycerides(TG)
甘油三酯
26
Cardiomyopathy
心肌病
24
Cardiomyopathies
心肌病
20
Atherosclerosis(AS)
动脉粥样硬化
17
Statins
他汀
13
Total Cholesterol(TC)
总胆固醇
11
Pulmonary Embolism(PE)
肺栓塞
10
Hyperlipidemias
高脂血症
10
Congenital Heart Disease
先天性心脏病
9
Coronary Heart Disease(CHD)
冠状动脉粥样硬化性心脏病
9
Hypercholesterolemia
高胆固醇血症
9
Percutaneous Coronary Intervention(PCI)
经皮冠状动脉介入治疗
8
Optical Coherence Tomography(OCT)
光学相干断层扫描
8
Deep Vein Thrombosis(DVT)
深静脉血栓
8
Cardiotoxicity
心脏毒性
7
Cardiomyopathy, Dilated
扩张型心肌病
7
Atrial Fibrillation Ablation
心房颤动消融术
7
Lipoprotein(a)(Lp(a))
脂蛋白a
7
Atrial Fibrillation Screening
房颤筛查
7
Anticoagulants
抗凝剂
7
Dilated cardiomyopathy
扩张型心肌病
6
Boston Science
波士顿科学
6
Aortic Valve Stenosis
主动脉瓣狭窄
6
Acute Coronary Syndrome(ACS)
急性冠脉综合征
5
Cerebrovascular Diseases
脑血管病
5
ST Elevation Myocardial Infarction(STEMI)
ST段抬高型心肌梗死
5
mitral regurgitation(MR)
二尖瓣反流
5
Antiarrhythmic Drugs(ADD)
抗心律失常药
5
Hypertriglyceridemia(HTG)
高甘油三酯血症
5
Hypertrophic cardiomyopathy(HCM)
肥厚型心肌病
5
Antithrombotic Therapy for Atrial Fibrillation
房颤患者抗凝治疗
5
Apolipoproteins B(ApoB)
载脂蛋白B
4
Transcatheter edge-to-edge repair(TEER)
经导管缘对缘修复
4
Lidocaine
利多卡因
4
Pulsed Field Ablation(PFA)
脉冲电场消融术
4
Cardiomyopathy, Hypertrophic(HCM)
肥厚型心肌病
4
Myocarditis
心肌炎
4
Acute Heart Failure(AHF)
急性心力衰竭
3
Chronic Heart Failure(CHF)
慢性心力衰竭
3
Heart Failure with preserved Ejection Fraction(HFpEF)
射血分数保留的心力衰竭
3
Non-ST Elevation Myocardial Infarction(NSTEMI)
非ST段抬高型心肌梗死
3
Persistent Atrial Fibrillation
持续性心房颤动
3
Dabigatran
达比加群
3
Proprotein Convertase Subtilisin/Kexin type-9 inhi...(PCSK9i)
前蛋白转化酶枯草溶菌素9抑制剂
3
Transcatheter Aortic Valve Replacement(TAVR)
经导管主动脉瓣置换术
3
Aortic Valve Regurgitation(AR)
主动脉瓣反流
3
Rosuvastatin
瑞舒伐他汀
2
Pitavastatin
匹伐他汀
2
Diabetic cardiomyopathy(DCM)
糖尿病性心肌病
2
High Density Lipoprotein Cholesterol(HDL-C)
高密度脂蛋白胆固醇
2
Patent oval foramen(PFO)
卵圆孔未闭
2
Ventricular septal defect(VSD)
室间隔缺损
2
mavacamten
2
Mitral Valve Insufficiency
二尖瓣关闭不全
2
Aortic Valve Disease
主动脉瓣疾病
2
Aortic Valve Insufficiency
主动脉瓣关闭不全
2
Metoprolol
美托洛尔
2
Propranolol
普萘洛尔
2
Amiodarone
胺碘酮
2
Apixaban
阿哌沙班
2
Oral Anticoagulants(OAC)
口服抗凝药
2
Non-vitamin K Oral Anticoagulants(NOAC)
新型口服抗凝药
2
Warfarin
华法林
2
Paroxysmal Atrial Fibrillation(PAF)
阵发性心房颤动
2
Rivaroxaban
利伐沙班
2
Essential Hypertension
原发性高血压
2
Heart Failure with reduced Ejection Fraction(HFrEF)
射血分数降低的心力衰竭
2
Sinus Tachycardia
窦性心动过速
2
Cancer Therapy-Related Venous Thromboembolism
肿瘤治疗相关静脉血栓栓塞
1
Anthracycline Chemotherapy-Related Cardiac Dysfun...
蒽环类化疗相关心功能不全
1
Immune Checkpoint Inhibitor-Related Cardiac Dysfun...
免疫检查点抑制剂相关心功能不全
1
Sinus Arrhythmia
窦性心律失常
1
Fibric Acids
贝特类
1
Cancer Therapeutics-Related Coronary Artery Diseas...
肿瘤治疗相关冠状动脉疾病
1
Hypertensive Crisis
高血压危象
1
Permanent Atrial Fibrillation
永久性心房颤动
1
Edoxaban
艾多沙班
1
Dronedarone
决奈达隆
1
Diltiazem
地尔硫卓
1
Rhythm Control
节律控制
1
Radio-Frequency Catheter Ablation(RFCA)
射频导管消融术
1
Atenolol
阿替洛尔
1
Alirocumab
阿利西尤单抗
1
Pravastatin
普伐他汀
1
Atorvastatin
阿托伐他汀
1
Mitral valve transcatheter edge-to-edge repair(M-TEER)
经导管二尖瓣缘对缘修复
1
Tricuspid transcatheter edge-to-edge repair(T-TEER)
经导管三尖瓣缘对缘修复
1
Cardiovascular Guidelines
心血管疾病指南
1
Unstable Angina(UA)
不稳定性心绞痛
1
Pulmonary Valve Stenosis
肺动脉瓣狭窄
1
Tricuspid Valve Insufficiency
三尖瓣关闭不全
1
TAVR in TAVR(ViV)
瓣中瓣技术
1
Transcatheter Tricuspid Valve Replacement(TTVR)
经导管三尖瓣置换术
1
Mitral Valve Disease
二尖瓣疾病
1
Renal Denervation(RDN)
经肾动脉去交感神经术
1
Peripheral Arterial Disease(PAD)
外周动脉疾病
1
Stress-induced cardiomyopathy
应激性心肌病
1
Fractional Flow Reserve(FFR)
血流储备分数
1
Conventional Balloon
常规球囊
1
Sentinel
1
Intravascular Ultrasound(IVUS)
血管内超声
1
Percutaneous Transluminal Coronary Angioplasty(PTCA)
经皮冠状动脉腔内成形术
1
Enterprise
企业
1
Low Density Lipoprotein Cholesterol(LDL-C)
低密度脂蛋白胆固醇
1
Non-high-density Lipoprotein Cholesterol(non-HDL-C)
非高密度脂蛋白胆固醇
1
Rheumatic Heart Disease(RHD)
风湿性心脏病
1
atrial septal defect(ASD)
房间隔缺损
1
patent ductus arteriosus(PDA)
动脉导管未闭
编辑：赵婷、韩玉莲、牛祥
审校：赵婷、韩玉莲、丁克芳、牛祥
细胞疗法疫苗临床研究免疫疗法
2026-04-30
*本资料仅供医疗卫生专业人士参考，请勿向非医疗卫生专业人士发放
截至04月30日15点59分，近期共有 579 本期刊发布了 1148 篇文章，其中糖尿病相关的文章共 344 篇，覆盖 32 个领域的内容。中国专家参与发表的文章有 109 篇。今日，影响因子最高的文章刊登在 Journal of the American Medical Association (IF: 55.000) 期刊上。
今日头条
Headlines
01 Wound repair and regeneration IF: 03.400 糖尿病足溃疡住院后30天再入院：一项全国性分析
Sanaka, Krishna O, Mitra, Nandita, Margolis, David J, etc.
糖尿病足溃疡是糖尿病成人住院的常见原因，与高发病率和死亡率相关。住院后再入院仍然常见，但描述再入院模式和驱动因素的全国代表性证据有限。
这项回顾性队列研究使用了2022年美国全国再入院数据库，旨在描述30天全因再入院率，识别与再入院相关的因素，并比较美国糖尿病足溃疡住院成人的指标住院和再入院情况。通过诊断代码识别诊断为糖尿病足溃疡的成人住院，并进行调查加权分析以生成全国估计。
在估计的234,797次初始住院中，13.3%的患者在30天内再入院，超过了全国住院患者平均水平8.2%。再入院患者中肾脏疾病、心血管疾病和精神健康状况的患病率更高。多变量分析显示，肾脏疾病、心血管合并症、烟草使用、药物使用障碍和双相情感障碍与再入院风险增加相关。相反，初始住院期间的感染相关诊断和手术，包括骨感染、手术清创和下肢截肢，与再入院风险降低相关。再入院住院时间更长，急性全身性疾病患病率更高。
这些发现表明，糖尿病足溃疡住院后早期再入院主要由全身性医疗不稳定驱动，而非局部感染复发，强调了多学科住院和出院后护理策略的必要性。
本文由 韩玉莲 编辑
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Wound repair and regeneration | Volume 34, Issue 3
10.1111/wrr.70165
02 Journal of diabetes IF: 03.700 糖尿病神经病变的人口统计学和临床特征：来自2012-2017年韩国国民健康保险服务的数据
Jeong, Su Jin, Kim, Sun Keun, Kim, Chong Hwa, etc.
糖尿病神经病变（DN）是2型糖尿病（T2DM）最常见的慢性并发症，既往研究报告的患病率在23%至54.5%之间。本研究利用韩国国民健康保险服务（NHIS）2012年至2017年的数据，评估了DN的患病率、临床特征及治疗情况。
研究分析了NHIS样本数据中870万按年龄、性别、资格和收入分层的人群。DN的定义采用ICD-10编码（E10.4-E14.4, G59.0, G63.2, G99.0）以及同时开具糖尿病和DN处方的标准。计算了糖尿病患者中每年的DN患病率，并比较了有和无DN患者的治疗模式及患者特征。
结果显示，DN患病率从2012年的23.4%下降至2017年的21.5%。约半数DN患者接受了药物治疗，其中单药治疗比例高达82%，二联治疗占15%，三联治疗占3%。最常处方的药物是α-硫辛酸（52.1%-55.0%），其次是抗惊厥药（30.4%-34.5%）、三环类抗抑郁药、SNRIs和γ-亚麻酸。DN患者通常年龄较大，女性居多，且合并症更多，如高血压、血脂异常、心血管疾病、糖尿病足和截肢。他们更可能使用胰岛素或多种口服降糖药。
结论指出，约四分之一的T2DM患者患有DN，其中半数接受了治疗，主要为α-硫辛酸单药治疗。DN患者往往年龄较大且合并多种疾病，导致住院率更高。
本文由 天纳乾坤 编辑
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Journal of diabetes | Volume 18, Issue 5
10.1111/1753-0407.70196
03 JAMA dermatology IF: 11.000 美国国家银屑病基金会关于GLP-1受体激动剂治疗银屑病的入门指南：综述
Samip Sheth, Joseph F. Merola, Brittany N. Weber, Ronald Prussick, Jensen Yeung, Clive Liu, etc.
美国国家银屑病基金会医学委员会近日在《JAMA dermatology》上发表了一篇综述，为皮肤科医生介绍了GLP-1受体激动剂（GLP-1 RAs）在银屑病治疗中的应用。
银屑病是一种慢性免疫介导疾病，常伴有心血管、代谢、肌肉骨骼、精神、肝脏、肾脏和肺部共病。GLP-1 RAs已获美国食品药品监督管理局批准用于2型糖尿病、肥胖、心血管风险降低、慢性肾脏病、阻塞性睡眠呼吸暂停和代谢功能障碍相关脂肪性肝炎，这些疾病在银屑病患者中常见。新出现的证据表明，GLP-1 RAs和双重葡萄糖依赖性促胰岛素多肽/GLP-1激动剂可能通过免疫调节改善银屑病皮损。如果在大规模随机临床试验中得到证实，基于GLP-1的疗法可能为同时治疗皮肤疾病和心血管代谢共病提供机会。
综述的观察部分指出，GLP-1 RAs与银屑病面积和严重程度指数（PASI）评分降低相关，尤其在肥胖或2型糖尿病患者中。研究报告PASI相对降低约40%至80%，同时生活质量改善，但大多数研究规模较小（7-48例患者）、短期（≤6个月）且缺乏对照组。司美格鲁肽和利拉鲁肽与C反应蛋白、白细胞介素-6、血脂和内脏脂肪减少相关。在小型转化队列中，PASI改善与浅表脂肪和真皮γδ T细胞密度减少相关。GLP-1 RAs可与甲氨蝶呤、环孢素和生物制剂安全联用。不良反应主要为短暂胃肠道症状，胰腺炎和胆囊事件罕见。早期数据显示代谢和免疫调节双重益处。
综述结论认为，基于GLP-1的疗法靶向银屑病中共享的代谢和炎症通路。当前证据支持在选定的代谢共病患者中考虑辅助使用，但最终结论尚需更大规模随机临床试验证实。
本文由 韩玉莲 编辑
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JAMA dermatology | Ahead of Print.
10.1001/jamadermatol.2026.0859
04 Frontiers in endocrinology IF: 04.600 糖尿病视网膜病变与焦虑和抑郁的双向关系：一项荟萃分析
Fan, Seng, Gai, Ziyue, Ma, Hui, Wen, Ziye, Ma, Chunlei, Fan, Dongying, etc.
一项发表于《Frontiers in Endocrinology》的荟萃分析系统评估了糖尿病视网膜病变（DR）与焦虑、抑郁之间的双向关系。研究共纳入34项观察性研究，涉及383,195例患者，覆盖14个国家。
结果显示，DR患者发生抑郁的风险显著高于非DR患者（OR=1.58，95%CI:1.24-2.02，P<0.001）；反之，抑郁患者发生DR的风险也显著升高（OR=2.13，95%CI:1.53-2.98，P<0.001），提示两者存在双向关系。此外，DR患者发生焦虑的风险是非DR患者的2.23倍（95%CI:1.07-4.68，P=0.033）。
亚组分析表明，研究设计、地区和混杂因素可能是异质性的来源。敏感性分析显示结果总体稳健，但存在发表偏倚。
研究建议，在DR的临床治疗中应重视患者的心理状态，实施个性化心理护理，以改善患者预后。
本文由 韩玉莲 编辑
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Frontiers in endocrinology | Volume 17, Issue
10.3389/fendo.2026.1764745
中国发表（109）
China
Scientific reports IF: 03.900Ahead of Print.No.01A case control study of subjective sleep characteristics and polycystic ovary syndrome主观睡眠特征与多囊卵巢综合征的病例对照研究DOI: 10.1038/s41598-026-50477-3
Complement Ther Clin Pract IF: 03.000Ahead of Print.No.02Effect of acupoint catgut embedding therapy on polycystic ovary syndrome: a systematic review and meta-analysis穴位埋线疗法对多囊卵巢综合征有效性的系统评价与Meta分析DOI: 10.1016/j.ctcp.2026.102056
Journal of hazardous materials IF: 11.300Ahead of Print.No.03Biomarker-anchored screening of dietary microplastics via a gut microbiota-informed machine learning model基于肠道微生物组信息的机器学习模型实现膳食微塑料的生物标志物锚定筛查DOI: 10.1016/j.jhazmat.2026.142219
Chung-Hua Wai K'o Tsa ChihAhead of Print.No.04[Define benchmarks for low-risk sleeve gastrectomy: based on the greater China metabolic and bariatric surgery database]低风险袖状胃切除术的基准定义：基于大中华区减重代谢手术数据库DOI: 10.3760/cma.j.cn112139-20251110-00525
Orthopaedic surgery IF: 02.100Ahead of Print.No.05Research Progress on Risk Factors for Acute Kidney Injury After Antibiotic-Loaded Bone Cement Spacer Treatment for Periprosthetic Joint Infection抗生素骨水泥间隔物治疗假体周围感染后急性肾损伤危险因素的研究进展DOI: 10.1111/os.70327
Mol Cell Endocrinol IF: 03.600Ahead of Print.No.06Adiponectin ameliorates chronic-intermittent-hypoxia-induced insulin resistance by modulating macrophage inflammation in visceral white adipose tissue脂联素通过调节内脏白色脂肪组织巨噬细胞炎症改善慢性间歇性缺氧诱导的胰岛素抵抗DOI: 10.1016/j.mce.2026.112809
Biomaterials advances IF: 06.000Ahead of Print.No.07A upper critical solution temperature- and synergistic antioxidant-responsive tremella polysaccharide hydrogel for enhancing diabetic wound healing一种上临界溶解温度和协同抗氧化响应的银耳多糖水凝胶促进糖尿病伤口愈合DOI: 10.1016/j.bioadv.2026.214900
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.08Association Between Maternal Diabetes and the Risk of Cancers in Mother-Offspring: A Meta-Analysis of 44.9 Million Pregnancies母亲糖尿病与母子癌症风险的关联：一项基于4490万妊娠的荟萃分析DOI: 10.1111/dom.70835
Scientific data IF: 06.900Ahead of Print.No.09Chinese Food Images for Full-cycle Nutrition Analysis Towards Diabetes Management面向糖尿病管理的全周期营养分析的中餐图像数据集DOI: 10.1038/s41597-026-07334-9
Endocrine journal IF: 02.100Ahead of Print.No.10Soluble tumor necrosis factor receptors in diabetes: risk sensing and receptor-resolved targeting糖尿病中可溶性肿瘤坏死因子受体：风险感知与受体靶向策略DOI: 10.1507/endocrj.EJ26-0050
Diabetes & metabolic syndrome IF: 03.400Ahead of Print.No.11Letter to the editor-The predictive value of estimated glucose disposal rate for all-cause and cardiovascular mortality in the US non-diabetic population aged ≥60 years: A population-based cohort study致编辑的信——估计葡萄糖利用率对美国≥60岁非糖尿病人群全因和心血管死亡率的预测价值：一项基于人群的队列研究DOI: 10.1016/j.dsx.2026.103419
Talanta IF: 06.100Ahead of Print.No.12A novel time-gated luminescent ruthenium(II) complex probe for highly sensitive detection of methylglyoxal in foods and complex biological samples一种新型时间门控发光钌(II)配合物探针用于食品和复杂生物样品中甲基乙二醛的高灵敏检测DOI: 10.1016/j.talanta.2026.129907
Environmental research IF: 07.700Ahead of Print.No.13Long-term exposure to ambient PM(2.5) constituents and risk of microvascular complications among individuals with type 2 diabetes mellitus: a nationwide cohort study in UK长期暴露于环境PM2.5组分与2型糖尿病患者微血管并发症风险：一项英国全国性队列研究DOI: 10.1016/j.envres.2026.124589
Photodiagnosis Photodyn Ther IF: 02.600Ahead of Print.No.14Correlation between fundus color and retinal microcirculation in Type 2 Diabetes Mellitus patients2型糖尿病患者眼底颜色与视网膜微循环的相关性DOI: 10.1016/j.pdpdt.2026.105493
Ophthalmology IF: 09.500Ahead of Print.No.15Decoding Gene-Lifestyle Synergy in Diabetic Retinopathy Development: A Transethnic Prospective Cohort Study解码糖尿病视网膜病变发展中的基因-生活方式协同作用：一项跨种族前瞻性队列研究DOI: 10.1016/j.ophtha.2026.04.017
Biomedizinische Technik IF: 01.800Ahead of Print.No.16RetinalFRNet: retinal vessel segmentation in OCTA images using the feature reconstruction networkRetinalFRNet：利用特征重建网络在OCTA图像中进行视网膜血管分割DOI: 10.1515/bmt-2026-0107
Bioorganic chemistry IF: 04.700Ahead of Print.No.17Puerarin alleviates type 2 diabetes by targeting AKT1 to inhibit ferroptosis: Integrating network pharmacology, proteomics and experimental validation葛根素通过靶向AKT1抑制铁死亡缓解2型糖尿病：网络药理学、蛋白质组学与实验验证的整合研究DOI: 10.1016/j.bioorg.2026.109915
Immunopharmacol Immunotoxicol IF: 03.000Ahead of Print.No.18Vildagliptin alleviates cardiomyocyte apoptosis and inflammatory responses in the treatment of non-valvular atrial fibrillation by regulating the NO/sGC/cGMP signaling pathway维格列汀通过调节NO/sGC/cGMP信号通路减轻非瓣膜性心房颤动中的心肌细胞凋亡和炎症反应DOI: 10.1080/08923973.2026.2639559
Cell reports. Methods IF: 04.500Ahead of Print.No.19Integrated multi-dimensional modeling of non-model bacteria identifies engineering targets for acarbose biosynthesis optimization非模式细菌的多维整合建模鉴定阿卡波糖生物合成优化的工程靶点DOI: 10.1016/j.crmeth.2026.101426
Journal of ethnopharmacology IF: 05.400Ahead of Print.No.20Corrigendum to "Integrative pharmacology reveals the mechanisms of Erzhi Pill, a traditional Chinese formulation, against diabetic cardiomyopathy" [J. Ethnopharmacol., 296, (2022), 115474]对《整合药理学揭示传统中药方剂二至丸抗糖尿病心肌病的作用机制》[J. Ethnopharmacol., 296, (2022), 115474]的勘误DOI: 10.1016/j.jep.2026.121734
Cardiovascular Diabetology IF: 10.600Ahead of Print.No.21Metabolomic signatures of hepatic steatosis reveal heterogeneity in cardiometabolic risk and responses to lifestyle interventions in type 2 diabetes: a post hoc analysis肝脏脂肪变性的代谢组学特征揭示2型糖尿病中心血管代谢风险及生活方式干预反应的异质性：一项事后分析DOI: 10.1186/s12933-026-03194-0
ACS nano IF: 16.000Ahead of Print.No.22Self-Cascading Copper-Based Nanoassemblies Trigger Bacterial Cuproptosis-Like Death and Promote Wound Healing for Diabetic Drug-Resistant Bacterial Infections自级联铜基纳米组装体触发细菌铜死亡样死亡并促进糖尿病耐药细菌感染的伤口愈合DOI: 10.1021/acsnano.5c21619
Journal of medicinal chemistry IF: 06.800Ahead of Print.No.23Design and Synthesis of USP1 Inhibitors: Synergistic Antitumor Activity with PARP Inhibitors in Triple-Negative Breast CancerUSP1抑制剂的设计与合成：与PARP抑制剂在三阴性乳腺癌中的协同抗肿瘤活性DOI: 10.1021/acs.jmedchem.5c03804
ACS nano IF: 16.000Ahead of Print.No.24Clinically Validated Leptin Receptor as a Target for Liposomal Delivery of Metformin in Endometriosis Therapy临床验证的瘦素受体作为脂质体递送二甲双胍治疗子宫内膜异位症的靶点DOI: 10.1021/acsnano.5c18417
Gait & posture IF: 02.400Ahead of Print.No.25Multi-modal sensor fusion in smart footwear to capture altered gait dynamics in patients with diabetic peripheral neuropathy: System validation and clinical applications智能鞋具多模态传感器融合捕捉糖尿病周围神经病变患者步态动力学改变：系统验证与临床应用DOI: 10.1016/j.gaitpost.2026.110196
PloS one IF: 02.600Volume 21, Issue 4No.26Artemether ameliorates type 1 diabetic liver injury alongside the associated defects in mitochondrial ultrastructure and central carbon metabolism蒿甲醚改善1型糖尿病肝损伤及相关的线粒体超微结构和中心碳代谢缺陷DOI: 10.1371/journal.pone.0348214
Diabetes Metab Res Rev IF: 06.000Volume 42, Issue 4No.27Metformin: Historical Origins, Mechanisms of Action, and Emerging Clinical Applications二甲双胍：历史起源、作用机制及新兴临床应用DOI: 10.1002/dmrr.70171
Science progress IF: 02.900Volume 109, Issue 2No.28Leukocyte VCS parameters as potential auxiliary markers associated with diabetes and its inflammatory complications: A retrospective cross-sectional study白细胞VCS参数作为糖尿病及其炎症并发症潜在辅助标志物的回顾性横断面研究DOI: 10.1177/00368504261445505
Am J Chin Med IF: 05.500Ahead of Print.No.29Acupuncture for Neuropathic Pain: Mechanisms, Clinical Efficacy and Future Perspectives针灸治疗神经病理性疼痛：机制、临床有效性及未来展望DOI: 10.1142/S0192415X26500254
Future science OA IF: 02.100Volume 12, Issue 1No.30Mapping ophthalmic research on glycosylation and glycation: a PRISMA-compliant bibliometric and co‑citation analysis眼科糖基化与糖化研究图谱：一项符合PRISMA规范的文献计量与共引分析DOI: 10.1080/20565623.2026.2663167
International wound journal IF: 02.500Volume 21, Issue 2No.31Analysis of pathogen distribution and associated risk factors for surgical site infections following laparoscopic urological surgeries腹腔镜泌尿外科手术后手术部位感染的病原体分布及相关危险因素分析DOI: 10.1111/iwj.14721
Annals of hematology IF: 02.400Volume 105, Issue 5No.32Low dose of sitagliptin: effectively prevent liver aGVHD and accelerate neutrophil engraftment低剂量西格列汀：有效预防肝脏急性移植物抗宿主病并加速中性粒细胞植入DOI: 10.1007/s00277-026-07036-7
Minerva anestesiologica IF: 02.800Ahead of Print.No.33Efficacy of intranasal insulin in preventing postoperative delirium and its impact on insulin resistance in elderly non-cardiac surgical patients: a systematic review and meta-analysis鼻内胰岛素预防老年非心脏手术患者术后谵妄的有效性及其对胰岛素抵抗的影响：系统评价与荟萃分析DOI: 10.23736/S0375-9393.26.19719-3
Br J Hosp Med (Lond) IF: 01.800Volume 87, Issue 4No.34Clinical Efficacy of Continuous Nursing Plus Shared Outpatient Care on Remission of Type 2 Diabetes Mellitus延续性护理联合共享门诊管理对2型糖尿病缓解的临床有效性DOI: 10.31083/BJHM49861
Clin Pharmacol Drug Dev IF: 01.800Volume 15, Issue 5No.35Comparative Pharmacokinetics and Bioequivalence Assessment of Metformin/Pioglitazone Tablet in Fasting and Fed Conditions: A Randomized Study in Healthy Chinese Subjects二甲双胍/吡格列酮片在空腹和进食条件下的比较药代动力学和生物等效性评估：一项在中国健康受试者中开展的随机研究DOI: 10.1002/cpdd.70063
Br J Hosp Med (Lond) IF: 01.800Volume 87, Issue 4No.36Clinical Value of High-Channel 12-Lead Holter in Assisting Early Identification of Arrhythmias in High-Risk Populations高通道12导联动态心电图在高危人群心律失常早期识别中的临床价值DOI: 10.31083/BJHM52968
JAHA IF: 05.300Ahead of Print.No.37Allostatic Load of Glucose Homeostasis, Epigenetic Biomarkers, and All-Cause and Cardiovascular Death: A Prospective Cohort Study葡萄糖稳态的适应性负荷、表观遗传生物标志物与全因及心血管死亡：一项前瞻性队列研究DOI: 10.1161/JAHA.125.047287
Kaohsiung J Med Sci IF: 03.100Ahead of Print.No.38ZFP36L1 Enhances Microglial Ferroptosis in Ischemic Stroke by Reducing FTO-Mediated N6-Methyladenosine Demethylation of ACSL1 mRNAZFP36L1通过减少FTO介导的ACSL1 mRNA N6-甲基腺苷去甲基化增强缺血性卒中中的小胶质细胞铁死亡DOI: 10.1002/kjm2.70212
International wound journal IF: 02.500Volume 21, Issue 2No.39RETRACTED: The effect of placing drains and no drains after caesarean section in obese patients on patients' post-operative wound complications: A meta-analysis已撤回：肥胖患者剖宫产后放置引流管与不放置引流管对术后伤口并发症影响的荟萃分析DOI: 10.1111/iwj.14576
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.40Gut microbiome dysbiosis in PCOS: from pathogenesis to microbiome-targeted therapies多囊卵巢综合征中的肠道微生物群失调：从发病机制到微生物靶向治疗DOI: 10.3389/fendo.2026.1747766
BMC public health IF: 03.600Ahead of Print.No.41Associations between multiple air pollutants and insulin resistance in Chinese adults: the moderating role of physical activity多种空气污染物与中国成年人胰岛素抵抗的关联：体力活动的调节作用DOI: 10.1186/s12889-026-27595-8
Reprod Biol Endocrinol IF: 04.700Volume 24, Issue 1No.42Editorial expression of concern: Resveratrol relieves gestational diabetes mellitus in mice through activating AMPK编辑关注声明：白藜芦醇通过激活AMPK缓解小鼠妊娠期糖尿病DOI: 10.1186/s12958-026-01560-x
Fayixue zazhiVolume 42, Issue 1No.43[Synthetic Drug： Pregabalin]合成药物：普瑞巴林DOI: 10.12116/j.issn.1004-5619.2026.360302
BMC ophthalmology IF: 01.700Volume 26, Issue 1No.44Correlation between the expression levels of miR-199a-3p and FN1 in serum and aqueous humor and the severity of type 2 diabetic retinopathy in a Chinese population中国人群中血清和房水中miR-199a-3p与FN1表达水平与2型糖尿病视网膜病变严重程度的相关性DOI: 10.1186/s12886-026-04838-1
BMC endocrine disorders IF: 03.300Ahead of Print.No.45The role of resistance training in improving beta-cell function in type 2 diabetes: a systematic review and meta-analysis抗阻训练改善2型糖尿病β细胞功能的作用：系统综述与荟萃分析DOI: 10.1186/s12902-026-02286-y
Journal of nanobiotechnology IF: 12.600Ahead of Print.No.46Extracellular vesicles inherit lactate from aggregated MSCs to alleviate type 1 diabetes mellitus via H(2)S-induced CD8(+) T cell exhaustion细胞外囊泡继承聚集间充质干细胞的乳酸通过H2S诱导CD8+ T细胞耗竭缓解1型糖尿病DOI: 10.1186/s12951-026-04466-3
Frontiers in psychiatry IF: 03.200Volume 17, Issue No.47The associations of systemic inflammation and insulin resistance-related indicators with psychopathology and BDNF in patients with chronic schizophrenia慢性精神分裂症患者全身炎症和胰岛素抵抗相关指标与精神病理学及BDNF的关联DOI: 10.3389/fpsyt.2026.1802167
Frontiers in neurology IF: 02.800Volume 17, Issue No.48Beyond BMI: independent and opposing effects of overweight and obesity and triglycerides on 90-day functional outcomes after acute ischemic stroke超越体重指数：超重与肥胖和甘油三酯对急性缺血性卒中后90天功能结局的独立且相反的影响DOI: 10.3389/fneur.2026.1782157
Frontiers in immunology IF: 05.900Volume 17, Issue No.49Targeted regulation of adipose tissue macrophages from an immunometabolic perspective: a novel therapeutic approach for obesity-related metabolic disorders从免疫代谢角度靶向调控脂肪组织巨噬细胞：肥胖相关代谢性疾病的新治疗策略DOI: 10.3389/fimmu.2026.1803488
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.50Association between stress hyperglycemic ratio and stroke in older people with metabolic syndrome: a prospective cohort study from UK Biobank应激性高血糖比率与代谢综合征老年人群卒中风险的关联：一项来自英国生物样本库的前瞻性队列研究DOI: 10.3389/fendo.2026.1758847
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.51Endocrine-informed monitoring of scoliosis in Prader-Willi syndrome: integrating neuroendocrine pathophysiology, growth hormone therapy, and pubertal transitionPrader-Willi综合征脊柱侧弯的内分泌指导监测：整合神经内分泌病理生理学、生长激素治疗与青春期过渡DOI: 10.3389/fendo.2026.1803919
FCVM IF: 02.900Volume 13, Issue No.52Efficacy and safety of levosimendan in acute heart failure patients with different body mass index: a multicenter, retrospective, observational real-world study左西孟旦在不同体重指数急性心力衰竭患者中的有效性和安全性：一项多中心、回顾性、观察性真实世界研究DOI: 10.3389/fcvm.2026.1790085
Frontiers in nutrition IF: 05.100Volume 13, Issue No.53The correlation between nutrition index scores and nutrition status of preschool children in a district of Shanghai上海市某区学龄前儿童营养指数评分与营养状况的相关性研究DOI: 10.3389/fnut.2026.1746871
Frontiers in nutrition IF: 05.100Volume 13, Issue No.54Associations of umbilical cord vitamin D levels with childhood cardiometabolic risks: a longitudinal mother-child study脐带维生素D水平与儿童期心脏代谢风险的关联：一项纵向母婴研究DOI: 10.3389/fnut.2026.1777909
Frontiers in nutrition IF: 05.100Volume 13, Issue No.55Fasting blood glucose to high-density lipoprotein cholesterol ratio and MASLD risk: non-linear association and BMI mediation in non-diabetic adults空腹血糖与高密度脂蛋白胆固醇比值与非糖尿病成人脂肪性肝病风险的非线性关联及体重指数的中介作用DOI: 10.3389/fnut.2026.1818931
Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.56Predictive Value of the second-Trimester Triglyceride-Glucose Index and Its Derived Indices for Macrosomia in Gestational Diabetes Mellitus妊娠期糖尿病孕妇孕中期甘油三酯-葡萄糖指数及其衍生指数对巨大儿的预测价值DOI: 10.2147/DMSO.S577687
J Int Med Res IF: 01.500Volume 54, Issue 4No.57A metabolic-inflammatory phenotype of pelvic floor dysfunction: A machine learning-based cross-sectional study in a nationally representative US population盆底功能障碍的代谢炎症表型：一项基于机器学习、具有全国代表性的美国人群横断面研究DOI: 10.1177/03000605261438949
J Int Med Res IF: 01.500Volume 54, Issue 4No.58Association between anthropometric indices and mortality risk among individuals with depression: A population-based cohort study抑郁患者人体测量指标与死亡风险的关联：一项基于人群的队列研究DOI: 10.1177/03000605261442794
Am J Respir Cell Mol Biol IF: 05.300Ahead of Print.No.59FTO Alleviates COPD Pathogenesis by Demethylating S100A9 to Suppress ERK1/2-Drp1-Driven MitophagyFTO通过去甲基化S100A9抑制ERK1/2-Drp1驱动的线粒体自噬减轻COPD发病机制DOI: 10.1093/ajrcmb/aanag094
Diabetology & metabolic syndrome IF: 03.900Volume 18, Issue 1No.60Beyond the known: prospective research directions for the gut-brain axis in obesity and type 1 diabetes mellitus超越已知：肥胖与1型糖尿病中肠脑轴的未来研究方向DOI: 10.1186/s13098-025-02038-3
BMC women's health IF: 02.700Ahead of Print.No.61PCOS combined with obesity aggravates the metabolic and immune abnormality in females多囊卵巢综合征合并肥胖加重女性代谢与免疫异常DOI: 10.1186/s12905-026-04492-1
International wound journal IF: 02.500Volume 21, Issue 2No.62Evaluation of diabetic foot care knowledge, determinants of self-care practices and the efficacy of health education糖尿病足护理知识、自我护理实践的决定因素及健康教育的有效性评估DOI: 10.1111/iwj.14704
International wound journal IF: 02.500Volume 21, Issue 2No.63RETRACTED: Efficacy of autologous platelet-rich plasma combined with negative pressure sealing drainage in the treatment of patients with diabetic foot ulcer自体富血小板血浆联合负压封闭引流治疗糖尿病足溃疡患者的有效性：一项系统评价与荟萃分析DOI: 10.1111/iwj.14700
International wound journal IF: 02.500Volume 21, Issue 2No.64RETRACTED: Effects of continuing nursing intervention on high-risk patients with diabetic foot ulcers: A meta-analysis持续护理干预对高危糖尿病足溃疡患者有效性的荟萃分析DOI: 10.1111/iwj.14683
Frontiers in bioscience IF: 03.100Volume 31, Issue 4No.65Emodin Alleviates Lipid Accumulation and Renal Tubular Injury in Rats With DN via Inhibiting HIF-1α Expression大黄素通过抑制HIF-1α表达减轻糖尿病肾病大鼠脂质蓄积和肾小管损伤DOI: 10.31083/FBL49862
Frontiers in bioscience IF: 03.100Volume 31, Issue 4No.66Effect of Endogenous FGF21 Deficiency on the Inflammatory Microenvironment of the Retina内源性FGF21缺乏对视网膜炎症微环境的影响DOI: 10.31083/FBL47702
J Integr Neurosci IF: 02.700Volume 25, Issue 4No.67Regional Associations Between Ocular Vascular Parameters and Enlarged Perivascular Spaces in the Basal Ganglia and Centrum Semiovale眼部血管参数与基底节和半卵圆中心血管周围间隙扩大的区域关联DOI: 10.31083/JIN49070
J Diabetes Investig IF: 03.000Ahead of Print.No.68Comment on 'Glycemic control and renal function decline in patients with chronic coronary syndrome: A multicenter cohort study'对《慢性冠状动脉综合征患者的血糖控制与肾功能下降：一项多中心队列研究》的评论DOI: 10.1111/jdi.70325
Materials horizons IF: 10.700Ahead of Print.No.69Multi-kingdom biofilms breached: microneedle delivery of metabolically targeted organic silver-photosensitizers for polymicrobial infections in diabetic foot ulcers多界生物膜突破：微针递送代谢靶向有机银光敏剂治疗糖尿病足溃疡中的多种微生物感染DOI: 10.1039/d6mh00459h
J Diabetes Investig IF: 03.000Ahead of Print.No.70Letter to the Editor in response to the article 'Prevalence and risk factors of sarcopenia in Asian adults with type 2 diabetes: A systematic review and meta-analysis'对《亚洲2型糖尿病成人肌少症的患病率与危险因素：系统综述与荟萃分析》一文的致编辑信DOI: 10.1111/jdi.70323
Frontiers in surgery IF: 01.800Volume 13, Issue No.71Risk factors associated with postoperative necrosis after digital replantation: a systematic review and meta-analysis断指再植术后坏死相关危险因素的系统评价与Meta分析DOI: 10.3389/fsurg.2026.1795247
Frontiers in neurology IF: 02.800Volume 17, Issue No.72Incidence of cognitive impairment post first stroke: a systematic review and meta-analysis首次卒中后认知障碍发生率的系统评价与荟萃分析DOI: 10.3389/fneur.2026.1782749
Frontiers in physiology IF: 03.400Volume 17, Issue No.73Efficacy and safety of gabapentinoid combination therapy versus monotherapy for the treatment of neuropathic pain加巴喷丁类药物联合治疗与单药治疗神经病理性疼痛的有效性和安全性比较DOI: 10.3389/fphys.2026.1802999
Frontiers in medicine IF: 03.000Volume 13, Issue No.74Incidence and risk factors of oral mucosal pressure injury in patients with oral tracheal intubation: systematic review and meta-analysis经口气管插管患者口腔黏膜压力性损伤发生率及危险因素的系统评价与Meta分析DOI: 10.3389/fmed.2026.1783726
Frontiers in medicine IF: 03.000Volume 13, Issue No.75Association between serum 25-hydroxyvitamin D, nutritional status, and inflammatory markers in sepsis patients with and without sarcopenia脓毒症合并与不合并肌少症患者血清25-羟基维生素D、营养状态和炎症标志物的关联研究DOI: 10.3389/fmed.2026.1816016
Frontiers in medicine IF: 03.000Volume 13, Issue No.76Construction and validation of a machine learning-based prediction model for postoperative complications in patients with chronic otitis media基于机器学习的慢性中耳炎术后并发症预测模型的构建与验证DOI: 10.3389/fmed.2026.1805224
Frontiers in medicine IF: 03.000Volume 13, Issue No.77Impact of liuwei dihuang pills (decoction) on early diabetic nephropathy: a systematic review and meta-analysis六味地黄丸（汤）对早期糖尿病肾病影响的系统评价与Meta分析DOI: 10.3389/fmed.2026.1802975
Maternal-fetal medicine IF: 01.700Volume 8, Issue 2No.78Global Guidelines on Placenta Accreta Spectrum Disorders: A Commentary From the Chinese Perspective全球胎盘植入性疾病指南：来自中国视角的评论DOI: 10.1097/FM9.0000000000000320
Frontiers in immunology IF: 05.900Volume 17, Issue No.79Influences of dietary intake on Chinese women with gestational diabetes mellitus by inhibiting gut microbiome on plasma metabolome膳食摄入通过抑制肠道微生物组对血浆代谢组的影响在中国妊娠期糖尿病女性中的作用DOI: 10.3389/fimmu.2026.1745459
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.80Association of the glucose metabolism continuum (fasting plasma glucose/HbA1c) with tear-film stability and secretion: ocular surface evidence across non-diabetes, prediabetes, and diabetes血糖代谢连续谱（空腹血糖/糖化血红蛋白）与泪膜稳定性和分泌的关联：跨越非糖尿病、糖尿病前期和糖尿病的眼表证据DOI: 10.3389/fendo.2026.1788051
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.81Machine learning-based prediction of NAFLD in patients with type 2 diabetes using routine clinical and biochemical indicators基于常规临床和生化指标的机器学习预测2型糖尿病患者非酒精性脂肪性肝病DOI: 10.3389/fendo.2026.1761846
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.82New findings in diabetic kidney disease: correlation and enhanced combined diagnostic value of sclerostin and 25(OH)VD糖尿病肾脏病新发现：硬骨素与25(OH)VD的相关性及联合诊断价值提升DOI: 10.3389/fendo.2026.1817017
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.83The association of serum uric acid with severity and prognosis of patients with diabetic foot ulcers血清尿酸与糖尿病足溃疡患者严重程度及预后的关联DOI: 10.3389/fendo.2026.1732361
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.84Low early-pregnancy serum lipoprotein(a) as an independent associated factor for gestational diabetes mellitus: a retrospective cohort study孕早期血清脂蛋白(a)低水平是妊娠期糖尿病的独立相关因素：一项回顾性队列研究DOI: 10.3389/fendo.2026.1780579
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.85Correction: Multi-feature integrated machine learning prediction model for early nephropathy in elderly living with type 2 diabetes mellitus更正：多特征集成机器学习预测模型用于老年2型糖尿病患者早期肾病DOI: 10.3389/fendo.2026.1807912
Int Med Case Rep J IF: 00.600Volume 19, Issue No.86Ultrasound-Guided Superior Laryngeal Nerve Block Combined with Cricothyroid Membrane Puncture for Awake Tracheal Intubation in a Patient with a Laryngeal Tumor: A Case Report and Literature Review超声引导喉上神经阻滞联合环甲膜穿刺用于喉肿瘤患者清醒气管插管：病例报告与文献综述DOI: 10.2147/IMCRJ.S589800
Frontiers in nutrition IF: 05.100Volume 13, Issue No.87Association between cumulative changes of the C-reactive protein-triglyceride glucose index and the incidence of rapid kidney function decline: a nationwide prospective cohort studyC反应蛋白-甘油三酯葡萄糖指数累积变化与肾功能快速下降发生率的关联：一项全国性前瞻性队列研究DOI: 10.3389/fnut.2026.1795444
Frontiers in nutrition IF: 05.100Volume 13, Issue No.88Structural elucidation and antidiabetic activity of polysaccharides from the parasitic plant Orobanche cumana寄生植物向日葵列当多糖的结构解析与抗糖尿病活性研究DOI: 10.3389/fnut.2026.1785297
Frontiers in nutrition IF: 05.100Volume 13, Issue No.89Microbiota-metabolites interaction associated with glycemic improvement following a dietary herbal intervention in type 2 diabetes2型糖尿病膳食草药干预后与血糖改善相关的微生物群-代谢物相互作用DOI: 10.3389/fnut.2026.1793130
Frontiers in nutrition IF: 05.100Volume 13, Issue No.90New directions in mulberry leaf research for diabetes: a translational approach based on multi-component synergy桑叶糖尿病研究新方向：基于多组分协同的转化策略DOI: 10.3389/fnut.2026.1792767
Frontiers in pharmacology IF: 04.800Volume 17, Issue No.91FGFR1/YAP1 signaling in endothelial cells drives renal fibrosis and offers a therapeutic target内皮细胞中FGFR1/YAP1信号驱动肾脏纤维化并提供治疗靶点DOI: 10.3389/fphar.2026.1766265
Frontiers in pharmacology IF: 04.800Volume 17, Issue No.92Paeoniflorin as a candidate disease-modifying therapy for diabetic peripheral neuropathy: mechanisms, exposure challenges, and translational priorities芍药苷作为糖尿病周围神经病变候选疾病修饰疗法：机制、暴露挑战与转化优先事项DOI: 10.3389/fphar.2026.1751578
Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.93Development and Validation of a Nursing-Integrated Nomogram to Predict 1-Year Ulcer Recurrence in Patients with Diabetic Foot Ulcers After Endovascular Therapy整合护理评估的列线图预测糖尿病足溃疡患者血管内治疗后1年溃疡复发的开发与验证DOI: 10.2147/DMSO.S591186
The FASEB journal : IF: 04.200Volume 40, Issue 9No.94The E3 Ligase RNF8 Promotes Ubiquitination and Degradation of ChREBPα During Liver Stress ResponseE3连接酶RNF8在肝脏应激反应中促进ChREBPα的泛素化和降解DOI: 10.1096/fj.202600106R
Endocrinol Diabetes Metab IF: 02.600Volume 9, Issue 3No.95Hypoglycaemia Risk Prediction Models for Type 2 Diabetes: A Systematic Review and Meta-Analysis2型糖尿病低血糖风险预测模型的系统评价与荟萃分析DOI: 10.1002/edm2.70227
Journal of diabetes IF: 03.700Volume 18, Issue 5No.96Mitochondrial Homeostasis in Pancreatic β Cell Function: Mechanisms and Therapeutic Targets for Diabetes胰腺β细胞功能中的线粒体稳态：糖尿病的机制与治疗靶点DOI: 10.1111/1753-0407.70228
Chinese Medical Journal IF: 07.300Ahead of Print.No.97Molecular mechanisms and novel therapeutic targets of diabetic kidney disease糖尿病肾病的分子机制与新型治疗靶点DOI: 10.1097/CM9.0000000000004025
J Int Med Res IF: 01.500Volume 54, Issue 4No.98Emerging therapies for type 1 diabetes: Immunotherapy and gene editing advances1型糖尿病新兴疗法：免疫治疗与基因编辑进展DOI: 10.1177/03000605261440833
J Int Med Res IF: 01.500Volume 54, Issue 4No.99Endothelial activation and stress index links to cardiovascular disease in postmenopausal women mediated by arterial stiffness: A cross-sectional study of National Health and Nutrition Examination Survey 1999-2018内皮激活与应激指数与绝经后女性心血管疾病相关：动脉僵硬度的中介作用——基于1999-2018年美国国家健康与营养调查的横断面研究DOI: 10.1177/03000605261434398
J Int Med Res IF: 01.500Volume 54, Issue 4No.100Effects of probiotic supplementation on glycemic control in children with type 1 diabetes: A systematic review and meta-analysis益生菌补充对1型糖尿病儿童血糖控制的影响：系统评价与荟萃分析DOI: 10.1177/03000605261443077
Frontiers in nutrition IF: 05.100Volume 13, Issue No.101Plant-based caloric restriction diets versus conventional calorie-restricted diets for weight loss and metabolic health in obese adults: a 12-week randomized, open-label, non-inferiority trial植物性热量限制饮食与传统热量限制饮食对肥胖成人减重和代谢健康的影响：一项12周随机、开放标签、非劣效性试验DOI: 10.3389/fnut.2026.1805225
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.102Bidirectional relationship of diabetic retinopathy with anxiety and depression: a meta-analysis糖尿病视网膜病变与焦虑和抑郁的双向关系：一项荟萃分析DOI: 10.3389/fendo.2026.1764745
J Integr Neurosci IF: 02.700Volume 25, Issue 4No.103Roles of Metformin and Pioglitazone in Regulating A1-like Astrocyte Activation in EAE Mice二甲双胍和吡格列酮在调节EAE小鼠A1样星形胶质细胞激活中的作用DOI: 10.31083/JIN47364
Frontiers in microbiology IF: 04.500Volume 17, Issue No.104Metformin exacerbates diabetic amyotrophy via oxidative stress and gut microbiota alterations达格列净通过氧化应激和肠道菌群改变加重糖尿病性肌萎缩DOI: 10.3389/fmicb.2026.1778515
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Domestic animal endocrinology IF: 02.100Ahead of Print.No.69Ertugliflozin decreases the insulin spike in non-insulin dysregulated standardbred horses following intra-articular triamcinolone administration艾托格列净降低非胰岛素调节异常的标准马关节内注射曲安奈德后的胰岛素峰值DOI: 10.1016/j.domaniend.2026.107016
Annals of family medicine IF: 05.100Ahead of Print.No.70Underuse of Pharmacologic Therapies for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Before Specialist Evaluation专科评估前肌痛性脑脊髓炎/慢性疲劳综合征药物治疗使用不足DOI: 10.1370/afm.250266
Nature IF: 48.500Ahead of Print.No.71A cell atlas charts the immune architecture of diabetic kidney disease细胞图谱揭示糖尿病肾病的免疫结构DOI: 10.1038/d41586-026-01177-5
Cardiovascular Diabetology IF: 10.600Ahead of Print.No.72Cardiovascular–kidney–metabolic syndrome: a comprehensive review of pathophysiology, epidemiology, diagnosis, and management心血管-肾脏-代谢综合征：病理生理学、流行病学、诊断和管理的全面综述DOI: 10.1186/s12933-026-03177-1
JMIR serious games IF: 04.100Volume 14, Issue No.73User Experience of a Virtual Reality-Based Treadmill for Children With a Chronic Disease Affecting Physical Health: Cross-Sectional Feasibility Study基于虚拟现实的跑步机对患有影响身体健康的慢性疾病儿童的用户体验：横断面可行性研究DOI: 10.2196/82953
Hormone research in p?diatrics : IF: 02.700Ahead of Print.No.74U.S. Adolescents of Asian Ethnicity have Higher Risk of Polycystic Ovary Syndrome美国亚裔青少年患多囊卵巢综合征风险更高DOI: 10.1159/000552156
Journal of obesity IF: 03.900Volume 2026, Issue 1No.75Prevalence and Factors Associated With Severe Obesity Among U.S. Adults: A Cross-Sectional Study美国成年人重度肥胖的患病率及相关因素：一项横断面研究DOI: 10.1155/jobe/3831008
JMIR human factors IF: 03.000Volume 13, Issue No.76Continuous Glucose Monitoring for Personalized Nutrition in Real-World Vively App Users: Retrospective Observational Study真实世界Vively应用用户中持续葡萄糖监测用于个性化营养的回顾性观察研究DOI: 10.2196/80734
JMIR human factors IF: 03.000Volume 13, Issue No.77Evaluation of Combined Educational Methods on Motivational Interviewing for Final-Year Medical Students: Mixed Methods Study联合教育方法对医学生动机性访谈能力的影响：混合方法研究DOI: 10.2196/89126
Annals of Cardiac Anaesthesia IF: 01.300Ahead of Print.No.78Incidence and Associated Factors of ST-Segment Changes in Noncardiac Surgery Under General Anesthesia全身麻醉下非心脏手术ST段改变的发生率及关联因素DOI: 10.4103/aca.aca_243_25
Zh Nevrol Psikhiatr Im S S KorsakovaVolume 126, Issue 4. Vyp. 2No.79[Transitional cognitive syndrome: Reconsidered classification of cognitive disorders]过渡性认知综合征：认知障碍分类的再思考DOI: 10.17116/jnevro202612604247
PloS one IF: 02.600Volume 21, Issue 4No.80Catastrophic health care expenditure among older people with non-communicable diseases in 11 European Union Member States11个欧盟成员国患有非传染性疾病的老年人灾难性医疗支出研究DOI: 10.1371/journal.pone.0346341
Einstein IF: 01.100Volume 24, Issue No.81Factors associated with sleep quality and duration in mothers of children with autism spectrum disorder: a cross-sectional study自闭症谱系障碍儿童母亲睡眠质量与时长相关因素：一项横断面研究DOI: 10.31744/einstein_journal/2026AO2004
Clin J Am Soc Nephrol IF: 07.100Ahead of Print.No.82SGLT2 Inhibitors versus GLP-1 Receptor Agonists Type 2 Diabetes, The Kidney ConundrumSGLT2抑制剂与GLP-1受体激动剂在2型糖尿病中的比较：肾脏难题DOI: 10.2215/CJN.0000001068
Zh Nevrol Psikhiatr Im S S KorsakovaVolume 126, Issue 4. Vyp. 2No.83[Current evidence-based approaches to the treatment of vascular cognitive impairment]当前血管性认知障碍治疗的循证方法DOI: 10.17116/jnevro202612604278
PloS one IF: 02.600Volume 21, Issue 4No.84Spatial and temporal modeling of breast cancer mortality in Kansas: An R-INLA approach堪萨斯州乳腺癌死亡率时空建模：基于R-INLA方法DOI: 10.1371/journal.pone.0347607
PloS one IF: 02.600Volume 21, Issue 4No.85Implications of acute change in estimated Glomerular Filtration Rate (eGFR) for the effect of sodium-glucose cotransporter-2 inhibitors (SGLT-2i) on long-term endpoints估算肾小球滤过率急性变化对钠-葡萄糖协同转运蛋白2抑制剂长期终点效应的影响DOI: 10.1371/journal.pone.0347741
AIDS IF: 03.100Volume 40, Issue 6No.86SGLT2 inhibitor dapagliflozin attenuates HIV-associated cardiac fibrosis, steatosis and diastolic dysfunction in a mouse model via inhibition of TGFβ signalingSGLT2抑制剂达格列净通过抑制TGFβ信号减轻HIV相关的心脏纤维化、脂肪变性和舒张功能障碍（小鼠模型）DOI: 10.1097/QAD.0000000000004464
The Lancet HIV IF: 13.000Volume 13, Issue 5, Page e287-e356No.87Incidence, risk factors, and cardiovascular impact of hypertension in people with HIV: a secondary analysis of the REPRIEVE trialHIV感染者高血压的发病率、危险因素及心血管影响：REPRIEVE试验的二次分析DOI: 10.1016/S2352-3018(26)00036-6
PloS one IF: 02.600Volume 21, Issue 4No.88Criterion validity and divergent risk profiles of long-term opioid therapy across medicare and medicaid长期阿片类药物治疗在Medicare和Medicaid中的标准效度及风险特征差异DOI: 10.1371/journal.pone.0347943
JMIR research protocols IF: 01.500Volume 15, Issue No.89The Current Landscape of Remote Patient Monitoring Regarding Diabetes Mellitus and Hypoglycemia: Protocol for a Scoping Review远程患者监测在糖尿病和低血糖管理中的现状：范围综述方案DOI: 10.2196/88197
Science advances IF: 12.500Volume 12, Issue 18No.90IRS4 is a PI3K-activating cancer dependency up-regulated through DNA rearrangements or epigenetic mechanisms in multiple solid tumorsIRS4是一种通过DNA重排或表观遗传机制在多种实体瘤中上调的PI3K激活型癌症依赖性基因DOI: 10.1126/sciadv.aeb3503
Annals of Cardiac Anaesthesia IF: 01.300Ahead of Print.No.91Incidence and Predictors of Postoperative Atrial Fibrillation Following Cardiac Surgery: A Systematic Review心脏手术后新发房颤的发生率及预测因素：一项系统综述DOI: 10.4103/aca.aca_285_25
Heart Rhythm IF: 05.700Ahead of Print.No.92Identification of Clinical Risk Factors for Arrhythmia Recurrence in Atrial Fibrillation Patients Undergoing Catheter Ablation: A Systematic review and Meta-analysis房颤导管消融术后心律失常复发的临床危险因素识别：系统评价与荟萃分析DOI: 10.1016/j.hrthm.2026.04.046
Heart IF: 04.400Ahead of Print.No.93Derivation and validation of a prediction model for long-term mortality in patients with ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention: the PREDICT-ST-Elevation Myocardial Infarction scoreST段抬高型心肌梗死患者经皮冠状动脉介入治疗后长期死亡率预测模型的推导与验证：PREDICT-STEMI评分DOI: 10.1136/heartjnl-2026-327811
Indian Journal of Ophthalmology IF: 01.800Volume 74, Issue 5No.94Biosimilar anti-vascular endothelial growth factor agents: Clinical outcomes, safety, and cost-effectiveness in India生物类似药抗血管内皮生长因子制剂在印度的临床结局、安全性和成本有效性DOI: 10.4103/IJO.IJO_3222_25
JAMA dermatology IF: 11.000Ahead of Print.No.95Deuterated Pentoxifylline Analog in the Treatment of Necrobiosis Lipoidica: A Nonrandomized Clinical Trial氘代己酮可可碱类似物治疗类脂质渐进性坏死：一项非随机临床试验DOI: 10.1001/jamadermatol.2026.0863
Lasers in medical science IF: 02.400Volume 41, Issue 1No.96Photobiomodulation combined with dynamic thermal imaging as a diagnostic tool for chronic leg ulcers光生物调节联合动态热成像作为慢性腿部溃疡的诊断工具DOI: 10.1007/s10103-026-04878-5
Am J Physiol Heart Circ Physiol IF: 04.100Ahead of Print.No.97Myeloid transglutaminase 2 regulates Treg-Th17 balance in a female model of Angiotensin II-induced hypertension and vascular stiffening髓系转谷氨酰胺酶2在血管紧张素II诱导的高血压和血管硬化雌性模型中调节Treg-Th17平衡DOI: 10.1152/ajpheart.00095.2026
Journal of fluorescence IF: 03.100Ahead of Print.No.98Design and Optimization of a Glucose Fluorescence Nano-biosensor Based on Graft Copolymer of Poly(acrylic acid)-co-(vinyl phenyl boronic acid)-g-gelatin to Modify CdTe/TGA QDs基于聚丙烯酸-co-乙烯基苯硼酸-g-明胶接枝共聚物修饰CdTe/TGA量子点的葡萄糖荧光纳米生物传感器的设计与优化DOI: 10.1007/s10895-026-04763-y
International ophtalmology IF: 01.400Volume 46, Issue 1No.99Clinical and demographic characteristics of glaucoma patients in Kingston, Jamaica牙买加金斯敦青光眼患者的临床和人口学特征DOI: 10.1007/s10792-026-04020-y
J Pediatr Endocrinol Metab IF: 01.000Ahead of Print.No.100Psychosocial adaptation of parents of children with type 1 diabetes: a cross-sectional study1型糖尿病患儿父母的心理社会适应：一项横断面研究DOI: 10.1515/jpem-2026-0061
J Pediatr Endocrinol Metab IF: 01.000Ahead of Print.No.101Age and sexual maturation at Spermarche in boys with Laron syndromeLaron综合征男孩首次遗精的年龄与性成熟DOI: 10.1515/jpem-2026-0043
Advances in physiology education IF: 01.700Ahead of Print.No.102The Development and Impact of an Innovative Graduate Program To Promote Entry to Physiology-Related Careers: The Master of Health Science in Medical Physiology创新研究生项目促进生理学相关职业发展的开发与影响：医学生理学健康科学硕士DOI: 10.1152/advan.00060.2026
Diabetes care IF: 16.600Ahead of Print.No.103Misguided Brushes of a Pen Continue to Dismantle and Destroy Biomedical Research in the United States: We Can No Longer Afford Complacency and Fear. We Must All Act Now!错误的笔触持续瓦解和摧毁美国生物医学研究：我们不能再容忍自满与恐惧，必须立即行动！DOI: 10.2337/dci26-0068
Metab Syndr Relat Disord IF: 01.700Ahead of Print.No.104Serum Proenkephalin A as a Marker of Renal Dysfunction and Glycemic Status in Diabetic Nephropathy血清前脑啡肽A作为糖尿病肾病肾功能不全和血糖状态的标志物DOI: 10.1177/15578518261444701
Pancreas IF: 01.700Ahead of Print.No.105Predictive Power of Imaging: Assessing Parenchymal Fibrosis in Pediatric Chronic Pancreatitis影像学预测能力：评估儿童慢性胰腺炎实质纤维化DOI: 10.1097/MPA.0000000000002658
Pol Arch Intern Med IF: 04.700Volume 136, Issue 4No.106Corrections: Assessment of the type 2 diabetes risk using the Finnish Diabetes Risk Score questionnaire, and its predictors at the population level in Poland更正：使用芬兰糖尿病风险评分问卷评估2型糖尿病风险及其在波兰人群水平上的预测因素DOI: 10.20452/pamw.17283
Medical care research and review IF: 02.200Ahead of Print.No.107Defining the Social Needs Service Cascade: Evidence From A Multistakeholder Qualitative Study定义社会需求服务级联：来自多利益相关者定性研究的证据DOI: 10.1177/10775587261439173
Global spine journal IF: 03.000Ahead of Print.No.108Incidence and Risk Factors for 30- and 90-day Reoperations Following Biportal Endoscopic Lumbar Discectomy for Single-Level Lumbar Disc Herniations单节段腰椎间盘突出症双通道内镜下椎间盘切除术后30天和90天再手术的发生率及危险因素DOI: 10.1177/21925682261448186
Plast Reconstr Surg IF: 03.400Ahead of Print.No.109Massive Weight Loss with Bariatric Surgery and GLP-1RA Therapy Predicts Postoperative Complications Following Abdominal Body Contouring减重手术与GLP-1RA治疗导致的巨大体重下降预示腹部塑形术后并发症DOI: 10.1097/PRS.0000000000013015
Inflammopharmacology IF: 05.300Ahead of Print.No.110Dapagliflozin mitigates acute pancreatitis induced by L-arginine in Rats through modulation of TLR-4/NF-κB/NLRP3 pathway: integrated biochemical, histopathological, and in silico study达格列净通过调节TLR-4/NF-κB/NLRP3通路减轻L-精氨酸诱导的大鼠急性胰腺炎：整合生化、组织病理学和计算机模拟研究DOI: 10.1007/s10787-026-02190-w
Am J Physiol Renal Physiol IF: 03.400Ahead of Print.No.111Dapagliflozin ameliorates high-fat diet-induced, megalin-mediated autolysosomal dysfunction in proximal tubules via suppression of megalin-dependent endocytosis达格列净通过抑制megalin依赖性内吞改善高脂饮食诱导的近端肾小管megalin介导的自噬溶酶体功能障碍DOI: 10.1152/ajprenal.00448.2025
Archives of osteoporosis IF: 02.800Volume 21, Issue 1No.112Bone health in young adults with inflammatory arthritis: assessment of associated factors of low bone mineral density年轻成人炎症性关节炎患者的骨骼健康：低骨密度相关因素的评估DOI: 10.1007/s11657-026-01710-z
JAMA psychiatry IF: 17.100Ahead of Print.No.113Semaglutide and Effort-Based Decision-Making in Major Depressive Disorder: A Randomized Clinical Trial司美格鲁肽与重度抑郁症中基于努力的决策：一项随机临床试验DOI: 10.1001/jamapsychiatry.2026.0594
Irish journal of medical science IF: 01.600Ahead of Print.No.114Associations of Mediterranean, DASH, and MIND diet adherence with metabolic parameters in individuals with type 2 diabetes mellitus: a cross-sectional study地中海饮食、DASH饮食和MIND饮食依从性与2型糖尿病患者代谢参数的相关性：一项横断面研究DOI: 10.1007/s11845-026-04415-x
J Egypt Public Health Assoc IF: 02.500Volume 101, Issue 1No.115Psychometric evaluation of the Arabic brief forms of the diabetes distress scale in Egyptian patients with type II diabetes阿拉伯语简短版糖尿病痛苦量表在埃及2型糖尿病患者中的心理测量学评估DOI: 10.1186/s42506-026-00216-3
Retinal cases & brief reportsAhead of Print.No.116Atypical (Three-Quadrant) Central Retinal Vein Occlusion: A Report of two cases and review of literature非典型（三象限）视网膜中央静脉阻塞：两例报告及文献综述DOI: 10.1097/ICB.0000000000001929
Nursing research IF: 02.200Ahead of Print.No.117Perceived Family Support and Treatment Adherence in Older Adults With Type 2 Diabetes老年2型糖尿病患者感知到的家庭支持与治疗依从性DOI: 10.1097/NNR.0000000000000914
Wound repair and regeneration IF: 03.400Volume 34, Issue 3No.118A First-In-Human Study of Pyroligneous Extract, the Biomaterial Derived From Pyrolytic Palm Kernel Shell Wood Vinegar as a Novel Wound Healing Aid on Diabetic Foot Ulcer热解棕榈仁壳木醋液衍生的生物材料——焦木提取物作为糖尿病足溃疡新型伤口愈合辅助剂的首次人体研究DOI: 10.1111/wrr.70166
Multiple sclerosis : IF: 05.000Ahead of Print.No.119Use of semaglutide and tirzepatide among people with multiple sclerosis司美格鲁肽和替尔泊肽在多发性硬化患者中的使用情况DOI: 10.1177/13524585261442033
Food science of animal resources IF: 03.700Volume 44, Issue 1No.120Oral Administration of Lactilactobacillus curvatus LB-P9 Promotes Hair Regeneration in Mice口服弯曲乳杆菌LB-P9促进小鼠毛发再生DOI: 10.5851/kosfa.2023.e74
Clinical transplantation IF: 01.900Volume 40, Issue 5No.121Hypoglycemia Occurrence and Risk Factors in Insulin Independent Patients After Total Pancreatectomy With Islet Autotransplantation全胰腺切除联合胰岛自体移植后胰岛素独立患者低血糖的发生率及危险因素DOI: 10.1111/ctr.70549
Physiology IF: 10.300Ahead of Print.No.122Multicellular Crosstalk and Therapeutic Vaccines in Heart Failure心力衰竭中的多细胞串扰与治疗性疫苗DOI: 10.1152/physiol.00007.2026
JAMA Network Open IF: 09.700Volume 9, Issue 4No.123Hypertrophic Cardiomyopathy and Risk of Out-of-Hospital Cardiac Arrest肥厚型心肌病与院外心脏骤停风险DOI: 10.1001/jamanetworkopen.2026.9673
Am J Physiol Regul Integr Comp Physiol IF: 02.300Ahead of Print.No.124B-Raf is required for normal murine cardiac development and functionB-Raf对小鼠正常心脏发育和功能是必需的DOI: 10.1152/ajpregu.00063.2025
The Prostate IF: 02.500Ahead of Print.No.125Prostate Cancer, Genetic Susceptibility, and Risk of Chronic Non-Urological Complications前列腺癌、遗传易感性与慢性非泌尿系统并发症风险DOI: 10.1002/pros.70190
J Eval Clin Pract IF: 02.100Volume 32, Issue 4No.126A Remote Chronic Disease Management Program to Improve Cardiovascular and Metabolic Outcomes in a Diverse Community-Based Diabetic Population: Study Design of the TAMIS Trial远程慢性病管理项目改善多样化社区糖尿病人群心血管和代谢结局：TAMIS试验研究设计DOI: 10.1111/jep.70456
Cell biochemistry and biophysics IF: 02.500Ahead of Print.No.127Distinct Antibody Signatures to Human Endogenous Retroviruses and Mycobacterium Paratuberculosis in Newly Diagnosed Tunisian Type 1 Diabetes Patients新诊断突尼斯1型糖尿病患者中人内源性逆转录病毒和副结核分枝杆菌的独特抗体特征DOI: 10.1007/s12013-026-02068-2
Journal of Human Hypertension IF: 03.400Ahead of Print.No.128Consensus on the management of hypertension in individuals with diabetes by Asian-Pacific Society of hypertension (APSH) & Diabetes Asia Study Group (DASG).亚太高血压学会与糖尿病亚洲研究组关于糖尿病患者高血压管理的共识DOI: 10.1038/s41371-026-01150-9
JAMA Cardiology IF: 14.100Ahead of Print.No.129Timeliness of Transthyretin Cardiac Amyloidosis Diagnosis in the Medicare Population医疗保险人群中转甲状腺素蛋白心脏淀粉样变性诊断的及时性DOI: 10.1001/jamacardio.2026.0833
JACC IF: 22.300Ahead of Print.No.130Development and Validation of a Clinical Polygenic Risk Report in U.S.-Based Health Systems for 8 Cardiovascular Conditions美国医疗系统中8种心血管疾病临床多基因风险报告的开发与验证DOI: 10.1016/j.jacc.2026.03.035
Mol Cell Biochem IF: 03.700Ahead of Print.No.131Elevated placental inflammation as a mediator of adverse outcomes in gestational diabetes mellitus胎盘炎症升高作为妊娠期糖尿病不良结局的介导因素DOI: 10.1007/s11010-026-05561-7
Irish journal of medical science IF: 01.600Ahead of Print.No.132Reduced fetal MAPSE and TAPSE in gestational diabetes mellitus: a prospective case-control study妊娠期糖尿病胎儿二尖瓣环收缩期位移与三尖瓣环收缩期位移降低：一项前瞻性病例对照研究DOI: 10.1007/s11845-026-04426-8
Soc Psychiatry Psychiatr Epidemiol IF: 03.500Ahead of Print.No.133Association between maternal pregnancy complications and long-term depressive and anxiety disorders: evidence from the UK millennium cohort study母体妊娠并发症与长期抑郁和焦虑障碍的关联：来自英国千禧队列研究的证据DOI: 10.1007/s00127-026-03094-4
JAHA IF: 05.300Ahead of Print.No.134Acute Impact of Transcatheter Edge-to-Edge Repair of Tricuspid Regurgitation on Right Ventricular Hemodynamics经导管缘对缘修复三尖瓣反流对右心室血流动力学的急性影响DOI: 10.1161/JAHA.125.047560
Endokrynologia Polska IF: 02.100Volume 77, Issue 2No.135Eradicating hyperandrogenism? Hormonal changes following Helicobacter pylori eradication in women with polycystic ovary syndrome: an observational case series根除幽门螺杆菌后多囊卵巢综合征女性的激素变化：一项观察性病例系列研究DOI: 10.5603/ep.110428
Saudi pharmaceutical journal IF: 03.400Volume 34, Issue 2No.136Efficacy and safety of pharmacological and procedural interventions in the management of hypertriglyceridemia-induced acute pancreatitis: a systematic review药物和介入干预治疗高甘油三酯血症诱导的急性胰腺炎的有效性和安全性：一项系统评价DOI: 10.1007/s44446-026-00078-y
Kaohsiung J Med Sci IF: 03.100Ahead of Print.No.137Efficacy of CPAP Therapy on Liver Steatosis and Insulin Resistance in Fatty Liver Patients With Obstructive Sleep Apnea: A 4-Year Follow-Up Cohort StudyCPAP治疗对阻塞性睡眠呼吸暂停合并脂肪性肝病患者肝脏脂肪变性和胰岛素抵抗的有效性：一项4年随访队列研究DOI: 10.1002/kjm2.70222
JAHA IF: 05.300Ahead of Print.No.138Glucose-6-Phosphate Dehydrogenase Modifies the Impact of Glucose on Arterial Aging in A Sex-Specific Manner葡萄糖-6-磷酸脱氢酶以性别特异性方式调节葡萄糖对动脉老化的影响DOI: 10.1161/JAHA.125.045538
JAMA IF: 55.000Ahead of Print.No.139Pigmentary Changes That Developed During Pregnancy妊娠期色素沉着变化DOI: 10.1001/jama.2026.2928
Rev Endocr Metab Disord IF: 08.000Ahead of Print.No.140Hypothalamic regulation of energy homeostasis: Quo vadis下丘脑对能量稳态的调控：何去何从DOI: 10.1007/s11154-026-10042-9
Obesity surgery IF: 03.100Ahead of Print.No.141Food Consumption by Processing Levels in Adults Two or More Years After Sleeve Gastrectomy: Associations with Surgical Outcomes and Eating Behaviors袖状胃切除术后两年及以上成年人按加工级别分类的食物消费：与手术结局和饮食行为的关联DOI: 10.1007/s11695-026-08582-9
Cell biochemistry and biophysics IF: 02.500Ahead of Print.No.142Effects of Diet-Induced Obesity and Exercise Intervention on Testicular Germ Cell Health: Modulation of SIRT1/FoxO1 and SIRT1/PGC-1α Signaling Axes饮食诱导肥胖与运动干预对睾丸生殖细胞健康的影响：SIRT1/FoxO1和SIRT1/PGC-1α信号轴的调节DOI: 10.1007/s12013-026-02076-2
BJS open IF: 04.500Volume 10, Issue 2No.143Sleeve gastrectomy versus Roux-en-Y-gastric bypass in patients with body mass index over 50 kg/m2: international multicentre cohort袖状胃切除术与Roux-en-Y胃旁路术在体重指数超过50 kg/m²患者中的比较：国际多中心队列研究DOI: 10.1093/bjsopen/zrag028
J Clin Pharmacol IF: 02.300Volume 66, Issue 5No.144Assessment of the Drug-Drug Interaction Potential of Lotiglipron (PF-07081532) with Midazolam, Omeprazole, Dabigatran, Rosuvastatin, and the Oral Contraceptives Levonorgestrel and Ethinyl Estradiol评估Lotiglipron（PF-07081532）与咪达唑仑、奥美拉唑、达比加群、瑞舒伐他汀以及口服避孕药左炔诺孕酮和炔雌醇的药物相互作用潜力DOI: 10.1002/jcph.70158
Health informatics journal IF: 02.300Volume 32, Issue 2No.145An informatics-based data-led prioritization strategy to facilitate objective and equitable care for an ethnically diverse urban cohort of people with type 1 diabetes: A proof-of-concept study基于信息学的数据主导优先排序策略：为种族多样化的城市1型糖尿病患者群体提供客观公平护理的概念验证研究DOI: 10.1177/14604582261436276
Crit Rev Food Sci Nutr IF: 08.800Ahead of Print.No.146A scoring system for validity assessment of biomarkers of food intake食物摄入生物标志物有效性评估评分系统DOI: 10.1080/10408398.2026.2633561
Nutrition and health IF: 01.400Ahead of Print.No.147Influence of autonomic function on the thermic effect of food and postprandial insulin sensitivity in individuals with obesity, submitted to a test meal with or without ultra-processed foods: Secondary analysis of a randomized trial自主神经功能对肥胖个体食物热效应和餐后胰岛素敏感性的影响：一项随机试验的二次分析DOI: 10.1177/02601060261446525
Nutrition reviews IF: 04.900Ahead of Print.No.148Methyl Donor Nutrient Intake as a Modulator of the Association between FTO Gene Variants and BMI: A Systematic Review with Meta-Analysis and Meta-Regression甲基供体营养素摄入作为FTO基因变异与体重指数之间关联的调节因素：系统综述、荟萃分析和荟萃回归DOI: 10.1093/nutrit/nuag035
Journal of human lactation : IF: 01.800Ahead of Print.No.149Linking Early Infant Growth With Milk-Derived Antibodies, Hormones, and Macronutrients During Exclusive Breastfeeding纯母乳喂养期间早期婴儿生长与母乳中抗体、激素和宏量营养素的关联DOI: 10.1177/08903344261430138
Open Heart IF: 02.800Volume 13, Issue 1No.150Are clinical improvements in anxiety or depression associated with improvement in walking fitness following a cardiac rehabilitation programme?心脏康复计划后焦虑或抑郁的临床改善是否与步行能力的改善相关？DOI: 10.1136/openhrt-2026-004051
Thyroid research IF: 01.800Volume 19, Issue 1No.151Measuring thyroid-stimulating hormone receptor antibodies using the IMMULITE(®) 2000 TSI assay is better than using the BRAHMS TRAK assay in an unselected clinical population, but both perform worse than expected: a real-world retrospective observational study在未经筛选的临床人群中，使用IMMULITE® 2000 TSI检测法测量促甲状腺激素受体抗体优于BRAHMS TRAK检测法，但两者表现均低于预期：一项真实世界回顾性观察研究DOI: 10.1186/s13044-026-00296-5
Int J Reprod Biomed IF: 01.800Volume 24, Issue 2No.152Therapeutic effects of Foeniculum vulgare and Achillea millefolium on ovarian function in a mouse model of polycystic ovary syndrome: An experimental study茴香和蓍草对多囊卵巢综合征小鼠模型卵巢功能的治疗作用：一项实验研究DOI: 10.18502/ijrm.v24i2.21053
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.153Molecular mechanisms of insulin resistance and altered carbohydrate metabolism in PCOS: a scoping review多囊卵巢综合征胰岛素抵抗与碳水化合物代谢改变的分子机制：一项范围综述DOI: 10.3389/fendo.2026.1810805
bioRxivVolume 2026, Issue No.154Distinct Molecular Mechanisms Regulate Feeding State-Dependent CO (2) Chemotaxis Plasticity During Different Life Stages in Caenorhabditis elegans不同生命阶段中进食状态依赖的CO2趋化可塑性的不同分子机制DOI: 10.64898/2026.02.06.704338
BMC research notes IF: 01.700Ahead of Print.No.155In vitro assessment of the impact of di(2-ethylhexyl) phthalate and its metabolites on the function and transcription of key glucose sensing proteins in a rat pancreatic β-cell line邻苯二甲酸二(2-乙基己基)酯及其代谢物对大鼠胰腺β细胞系关键葡萄糖感应蛋白功能和转录影响的体外评估DOI: 10.1186/s13104-026-07830-6
JACC: AdvancesVolume 5, Issue 5No.156Characteristics, Management, and Outcomes of Diabetes Subtypes in Patients With Cardiogenic Shock心源性休克患者糖尿病亚型的特征、管理及主要终点DOI: 10.1016/j.jacadv.2026.102766
Diabetology & metabolic syndrome IF: 03.900Ahead of Print.No.157Prognostic value of advanced imaging biomarkers for the progression of diabetic retinopathy: a systematic review先进影像生物标志物对糖尿病视网膜病变进展的预后价值：一项系统评价DOI: 10.1186/s13098-026-02159-3
Current obesity reports IF: 11.000Volume 15, Issue 1No.158The Epidemiology of the Global Syndemic in Africa: New Evidence and Key Insights非洲全球共病流行病学：新证据与关键见解DOI: 10.1007/s13679-026-00717-4
Frontiers in health services IF: 02.700Volume 6, Issue No.159Therapeutic intensity and patient-reported outcomes among heart failure patients in a pharmacist-led medication therapy adherence clinic program in Malaysia马来西亚药师主导的药物治疗依从性门诊项目中心力衰竭患者的治疗强度与患者报告结局DOI: 10.3389/frhs.2026.1784432
Caspian J Intern Med IF: 01.000Volume 17, Issue 1No.160Acromegalic features and hypoglycemia: Doege-Potter syndrome肢端肥大症特征与低血糖：Doege-Potter综合征DOI: 10.22088/cjim.17.1.205
JCEM case reportsVolume 4, Issue 5No.161A rare case of dual hormone-secreting pulmonary neuroendocrine tumor causing concurrent Cushing syndrome and acromegaly一例罕见的双重激素分泌性肺神经内分泌肿瘤导致库欣综合征和肢端肥大症并存DOI: 10.1210/jcemcr/luag092
Journal of Hypertension IF: 04.100Volume 44, Issue 6No.162Response to letter 'Sex-specific associations between TyG index and emotional states'对《TyG指数与情绪状态的性别特异性关联》一信的回复DOI: 10.1097/HJH.0000000000004289
Int J Eat Disord IF: 04.300Ahead of Print.No.163Sex Differences in Social, Health, and Lifestyle Characteristics Associated With Binge-Eating Behaviors: Results From a French National Random Population-Based Study与暴食行为相关的社会、健康和生活方式特征的性别差异：基于法国全国随机人群研究的结果DOI: 10.1002/eat.70113
J Integr Neurosci IF: 02.700Volume 25, Issue 4No.164Lipid Ratio Biomarkers as Protective Factors for Depressive Symptoms in Newly Diagnosed Metabolic Syndrome: Evidence From Regression Modeling脂质比值生物标志物作为新诊断代谢综合征患者抑郁症状的保护因素：来自回归模型的证据DOI: 10.31083/JIN49628
Caspian J Intern Med IF: 01.000Volume 17, Issue 1No.165The association between appendicular skeletal muscle index and liver steatosis and fibrosis: A cross-sectional study四肢骨骼肌指数与肝脏脂肪变性和纤维化的关联：一项横断面研究DOI: 10.22088/cjim.17.1.113
Front Sports Act Living IF: 02.600Volume 8, Issue No.166Physiological and cortical determinants of exercise tolerance in sedentary women with obesity久坐肥胖女性运动耐量的生理和皮层决定因素DOI: 10.3389/fspor.2026.1771921
Int J Womens Health IF: 02.600Volume 18, Issue No.167Comparison of Surgical Outcomes Among Open, Laparoscopic, and Robotic Surgeries in Women with Obesity Diagnosed with Endometrial Cancer: Results from a Quaternary Hospital in Thailand肥胖子宫内膜癌患者开腹、腹腔镜与机器人手术结局比较：泰国一家四级医院的结果DOI: 10.2147/IJWH.S598487
JBMR plus IF: 02.400Volume 10, Issue 5No.168Pain medication use in patients with X-linked hypophosphatemia treated with burosumab: a retrospective real-world study布罗索尤单抗治疗X连锁低磷血症患者的止痛药使用：一项回顾性真实世界研究DOI: 10.1093/jbmrpl/ziag047
Journal of affective disorders reportsVolume 24, Issue No.169Insights from deep learning models on new-onset anxiety in patients following bariatric metabolic surgery深度学习模型对减重代谢手术后新发焦虑的洞察DOI: 10.1016/j.jadr.2026.101061
Frontiers in psychology IF: 02.900Volume 17, Issue No.170Didactic adaptation of basketball in physical education to reduce anxiety and emotional eating in adolescent girls with obesity: a randomized controlled trial体育教育中篮球教学适应性改编对肥胖青少年女性焦虑和情绪性进食的影响：一项随机对照试验DOI: 10.3389/fpsyg.2026.1753266
Front Behav Neurosci IF: 02.900Volume 20, Issue No.171Revisiting food addiction in the era of GLP-1-based obesity pharmacotherapy via neural reward pathways linking feeding and substance use在基于GLP-1的肥胖药物治疗时代重新审视食物成瘾：通过连接进食与物质使用的神经奖赏通路DOI: 10.3389/fnbeh.2026.1805953
J Diabetes Investig IF: 03.000Ahead of Print.No.172Validation of the ST1RE risk engine in Chinese with type 1 diabetes and comparison with the JADE, RECODe, and UKPDS risk scoresST1RE风险引擎在中国1型糖尿病患者中的验证及与JADE、RECODe和UKPDS风险评分的比较DOI: 10.1111/jdi.70316
British journal of nutrition IF: 03.000Ahead of Print.No.173Patterns of dietary habits are associated with metabolic health status in adults膳食习惯模式与成人代谢健康状态相关DOI: 10.1017/S0007114526106722
Mol Nutr Food Res IF: 04.200Volume 70, Issue 9No.174Maternal Chrono-Nutrition and Placental DNA Methylation: The BiSC Study母亲时间营养与胎盘DNA甲基化：BiSC研究DOI: 10.1002/mnfr.70465
Lipids IF: 01.600Ahead of Print.No.175Hepatic Lipids as Molecular Targets in Obesity-Associated Insulin Resistance in Rodent Models: A Systematic Review and Meta-Analysis啮齿动物模型中肝脏脂质作为肥胖相关胰岛素抵抗的分子靶点：系统综述与荟萃分析DOI: 10.1002/lipd.70061
J Diabetes Investig IF: 03.000Ahead of Print.No.176Time in range during caloric restriction in type 2 diabetes with obesity肥胖2型糖尿病患者热量限制期间的血糖在目标范围内时间DOI: 10.1111/jdi.70308
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.177Indirect Comparative Efficacy and Safety of Tirzepatide Versus Oral Semaglutide for the Treatment of Overweight and Obesity替尔泊肽与口服司美格鲁肽治疗超重和肥胖的间接比较有效性和安全性DOI: 10.1111/dom.70773
British journal of nutrition IF: 03.000Ahead of Print.No.178Contribution of meals to energy and nutrient intakes and implication of skipping meals on nutritional status among primary schoolchildren in Malaysia马来西亚小学生膳食对能量和营养素摄入的贡献及不吃饭对营养状况的影响DOI: 10.1017/S0007114526107314
J Health Popul Nutr IF: 02.800Ahead of Print.No.179Malnutrition among men in Ghana: socio-demographic factors and rural-urban differences加纳男性营养不良：社会人口因素与城乡差异DOI: 10.1186/s41043-026-01325-7
Allergy IF: 12.000Ahead of Print.No.180Longitudinal Follow-Up of Gut and Salivary Microbiota in Children With Food Protein-Induced Enterocolitis Syndrome食物蛋白诱导性小肠结肠炎综合征患儿肠道和唾液微生物群的纵向随访DOI: 10.1111/all.70363
Frontiers in bioscience IF: 03.100Volume 31, Issue 4No.181Potential Application of HIF-PH Inhibitors to Treat Kidney DiseasesHIF-PH抑制剂治疗肾脏疾病的潜在应用DOI: 10.31083/FBL47718
Frontiers in bioscience IF: 03.100Volume 31, Issue 4No.182The Gut-Lung Axis, Epigenetics and Respiratory Disease肠-肺轴、表观遗传学与呼吸系统疾病DOI: 10.31083/FBL48743
Revista de neurología IF: 00.800Volume 81, Issue 4No.183Peripheral Neuropathy: A Phenotype-Driven Review for Diagnosis and Management周围神经病变：基于表型的诊断与管理综述DOI: 10.31083/RN48384
Caspian J Intern Med IF: 01.000Volume 17, Issue 1No.184Investigating the effect of pirfenidone on lung CT scans in patients with severe COVID-19 Hospitalized at Shahid Sadoughi Hospital, Yazd, Iran吡非尼酮对重症COVID-19患者肺部CT扫描影响的研究DOI: 10.22088/cjim.17.1.163
Caspian J Intern Med IF: 01.000Volume 17, Issue 1No.185Detecting coronary artery disease among the individuals with left-sided dominant coronary circulation左侧优势型冠状动脉循环个体中冠状动脉疾病的检测DOI: 10.22088/cjim.17.1.173
Caspian J Intern Med IF: 01.000Volume 17, Issue 1No.186Association of interleukin-8 and neutrophil-to-lymphocyte ratio with clinical indices in diabetic nephropathy白细胞介素-8和中性粒细胞与淋巴细胞比值与糖尿病肾病临床指标的相关性DOI: 10.22088/cjim.17.1.191
Sleep AdvVolume 7, Issue 2No.187Using consumer sleep trackers for sleep extension interventions: retention, adherence, and user experiences使用消费者睡眠追踪器进行睡眠延长干预：保留率、依从性和用户体验DOI: 10.1093/sleepadvances/zpag025
Health science reports IF: 02.100Volume 9, Issue 5No.188How Pre-Pregnancy Weight and Polycystic Ovary Syndrome Impact Pregnancy Outcomes: A Population-Based Cohort Study孕前体重与多囊卵巢综合征对妊娠结局的影响：一项基于人群的队列研究DOI: 10.1002/hsr2.72088
Frontiers in ophthalmologyVolume 6, Issue No.189Use of preoperative swept-source optical coherence tomography in vitrectomy for advanced diabetic eye disease: a pilot study术前扫频源光学相干断层扫描在晚期糖尿病眼病玻璃体切除术中的应用：一项初步研究DOI: 10.3389/fopht.2026.1688660
Clin Med Insights Endocrinol Diabetes IF: 03.000Volume 19, Issue No.190Euthyroid Sick Syndrome Precipitated By Rapid Weight Loss Following Semaglutide Initiation: A Case Report司美格鲁肽治疗后快速减重诱发正常甲状腺病态综合征：一例病例报告DOI: 10.1177/11795514261443862
RSC advances IF: 04.600Volume 16, Issue 24No.191Bacterial metabolite-directed synthesis of biogenic TiO(2)-Zn nanocomposites: characterization and multifunctional biomedical evaluation细菌代谢物导向合成生物源TiO₂-Zn纳米复合材料：表征与多功能生物医学评价DOI: 10.1039/d6ra00881j
Frontiers in chemistry IF: 04.200Volume 14, Issue No.192Phytochemical profiling and multi-target pharmacological evaluation of Symphyotrichum squamatum unveils its potential as a source of antidiabetic and anti-inflammatory agentsSymphyotrichum squamatum的植物化学谱系及多靶点药理学评价揭示其作为抗糖尿病和抗炎药物来源的潜力DOI: 10.3389/fchem.2026.1734411
J Pharm Policy Pract IF: 02.500Volume 19, Issue 1No.193Asthma and chronic obstructive disease overlap (ACO), a systematic review of prevalence and co-morbidity factors based on diagnostic criteria哮喘与慢性阻塞性肺疾病重叠（ACO）：基于诊断标准的患病率和共病因素系统综述DOI: 10.1080/20523211.2026.2654490
J Pharm Policy Pract IF: 02.500Volume 19, Issue 1No.194The prevalence and predictor factors of urinary tract infection in type 2 diabetes mellitus patients receiving SGLT2 inhibitors in Qatar: A retrospective cohort study卡塔尔2型糖尿病患者使用SGLT2抑制剂后尿路感染的患病率及预测因素：一项回顾性队列研究DOI: 10.1080/20523211.2026.2645913
Frontiers in public health IF: 03.400Volume 14, Issue No.195Central adiposity outperforms disordered eating behavior in predicting type 2 diabetes risk in young adults: an explainable machine learning approach中心性肥胖在预测年轻人2型糖尿病风险方面优于饮食行为紊乱：一项可解释机器学习方法DOI: 10.3389/fpubh.2026.1778156
Frontiers in public health IF: 03.400Volume 14, Issue No.196Correction: Influence of the COVID-19 pandemic on chronic disease management among indigenous people in Canada更正：COVID-19大流行对加拿大原住民慢性病管理的影响DOI: 10.3389/fpubh.2026.1817733
Int J Microbiol IF: 03.200Volume 2026, Issue No.197Coevolution of Human Diet and Gut Microbiome: Implications for Nutrigenomics and Cross-Population Health人类饮食与肠道微生物组的共同进化：对营养基因组学和跨人群健康的影响DOI: 10.1155/ijm/5597426
Germs IF: 01.700Volume 16, Issue 1No.198Variety of Clostridioides difficile Ribotypes in CDI Patients in Las Vegas, NV内华达州拉斯维加斯CDI患者中艰难梭菌核糖体类型的多样性DOI: 10.3390/germs16010002
Curēus IF: 01.300Volume 18, Issue 3No.199Elevated Lipoprotein(a) and Cardiovascular Outcomes After Percutaneous Coronary Intervention: A Systematic Review经皮冠状动脉介入治疗后脂蛋白(a)升高与心血管结局：一项系统评价DOI: 10.7759/cureus.106009
Curēus IF: 01.300Volume 18, Issue 3No.200Early-Remitting Neonatal Diabetes in a Growth-Restricted Preterm Infant Requiring Insulin: A Case Report生长受限早产儿需胰岛素治疗的早期缓解型新生儿糖尿病：一例病例报告DOI: 10.7759/cureus.106025
Frontiers in physiology IF: 03.400Volume 17, Issue No.201Modulation of the serotonergic system restores oxidative balance and gene expression in the brain and heart of rats with obesity induced by overnutrition血清素系统调节恢复营养过剩诱导肥胖大鼠脑和心脏的氧化平衡与基因表达DOI: 10.3389/fphys.2026.1783080
Frontiers in medicine IF: 03.000Volume 13, Issue No.202Systemic strategies to prevent early diabetic retinopathy: targeting polyunsaturated fatty acid metabolism and eicosanoid signaling预防早期糖尿病视网膜病变的系统性策略：靶向多不饱和脂肪酸代谢和类花生酸信号DOI: 10.3389/fmed.2026.1802443
J Clin Exp DentVolume 18, Issue 3No.203Nonsurgical Periodontal Therapy for Diabetes Patients with Periodontal Disease非手术牙周治疗对伴有牙周病的糖尿病患者的疗效DOI: 10.4317/jced.63729
J Public Health ResVolume 15, Issue 2No.204Understanding community needs: Comprehensive analysis of the family adoption program conducted in coastal region of South India理解社区需求：印度南部沿海地区家庭收养计划的综合分析DOI: 10.1177/22799036261439972
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.205Relationship between apolipoprotein M levels and diabetic retinopathy in patients with type 2 diabetes mellitus2型糖尿病患者载脂蛋白M水平与糖尿病视网膜病变的关系DOI: 10.3389/fendo.2026.1809680
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.206Dermatologic outcomes associated with glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes: a large-scale target trial emulation胰高血糖素样肽-1受体激动剂与2型糖尿病患者皮肤结局的关联：一项大规模目标试验模拟研究DOI: 10.3389/fendo.2026.1801203
Frontiers in digital health IF: 03.800Volume 8, Issue No.207ChatGPT for diabetes education: potential, accuracy, and accessibility in patient supportChatGPT在糖尿病教育中的应用：患者支持中的潜力、准确性与可及性DOI: 10.3389/fdgth.2026.1768843
bioRxivVolume 2026, Issue No.208Longitudinal in vivo human wound healing model defines key role for smooth muscle cells in ECM remodeling纵向体内人类伤口愈合模型定义平滑肌细胞在细胞外基质重塑中的关键作用DOI: 10.64898/2026.02.24.707845
JCEM case reportsVolume 4, Issue 5No.209Tirzepatide-associated hyponatremia in a patient with known arginine vasopressin deficiency替尔泊肽相关低钠血症在一例已知精氨酸加压素缺乏症患者中的报告DOI: 10.1210/jcemcr/luag110
Frontiers in pharmacology IF: 04.800Volume 17, Issue No.210The therapeutic potential of Vanilla planifolia: how its phytochemicals combat diabetes?香荚兰的治疗潜力：其植物化学物质如何对抗糖尿病？DOI: 10.3389/fphar.2026.1752315
Frontiers in pharmacology IF: 04.800Volume 17, Issue No.211Correction: Alpha-7 nicotinic acetylcholine receptor: targeting the interplay between inflammation, renin-angiotensin aldosterone system, and nervous system for the novel treatment of heart failureα7烟碱型乙酰胆碱受体：靶向炎症、肾素-血管紧张素-醛固酮系统与神经系统之间的相互作用用于心力衰竭的新型治疗DOI: 10.3389/fphar.2026.1841172
Front Clin Diabetes Healthc IF: 02.200Volume 7, Issue No.212The role of chromogranin A cleavage products in onset of type 1 and 2 diabetes嗜铬粒蛋白A裂解产物在1型和2型糖尿病发病中的作用DOI: 10.3389/fcdhc.2026.1812936
Diabetic medicine IF: 03.400Ahead of Print.No.213Considerations for the clinical use of teplizumab in stage 2 Type 1 diabetes: A Consensus Statement from the British Society of Paediatric Endocrinology and Diabetes (BSPED) and the Association of British Clinical Diabetologists (ABCD)替普利珠单抗在2型1型糖尿病临床应用的考量：英国儿科内分泌与糖尿病学会和英国临床糖尿病专家协会的共识声明DOI: 10.1111/dme.70329
Diabetic medicine IF: 03.400Ahead of Print.No.214Has the time come for a remission definition in type 1 diabetes? A functional perspective1型糖尿病缓解定义时机已到？功能性视角DOI: 10.1111/dme.70351
Cent Nerv Syst Agents Med ChemAhead of Print.No.215Unveiling the Neuroprotective Role of Nutritional Supplements in Neurodegenerative Diseases揭示营养补充剂在神经退行性疾病中的神经保护作用DOI: 10.2174/0118715249389608251108031453
British journal of nutrition IF: 03.000Ahead of Print.No.216Association between the Mediterranean dietary pattern and Metabolic dysfunction-associated steatotic liver disease (MASLD): A longitudinal analysis from UK BIOBANK地中海饮食模式与代谢功能障碍相关脂肪性肝病的关联：来自英国生物样本库的纵向分析DOI: 10.1017/S0007114526107351
Curr Opin Endocrinol Diabetes Obes IF: 02.700Volume 33, Issue 3No.217Editorial introduction编者按DOI: 10.1097/MED.0000000000000958
Medical decision making : IF: 02.300Ahead of Print.No.218A Microsimulation-Based Approach for Mitigating Societal Bias in Chronic Kidney Disease Data基于微观模拟的慢性肾脏病数据社会偏见缓解方法DOI: 10.1177/0272989X261432162
The journal of dermatology IF: 02.700Ahead of Print.No.219Drug-Induced Blaschkitis Associated With Dipeptidyl Peptidase-4 Inhibitor: A Case Report and Review of the Literature二肽基肽酶-4抑制剂相关药物诱导的Blaschkitis：病例报告及文献综述DOI: 10.1111/1346-8138.70296
Diabetes Technol Ther IF: 06.300Ahead of Print.No.220Safety and Effectiveness of MiniMed™ 780G Advanced Hybrid Closed-Loop Use with Ultrarapid Insulin Lispro-AABC in Pediatric and Adult Type 1 DiabetesMiniMed™ 780G高级混合闭环系统联合超速效胰岛素赖脯-aabc在儿童和成人1型糖尿病患者中的安全性和有效性DOI: 10.1177/15209156261444994
BMC nutrition IF: 02.200Ahead of Print.No.221Dietary advanced glycation end products and risk of cardiometabolic disorders in older adults: cross-sectional data from the 2007-2021 Korea National Health and Nutrition Examination Survey (KNHANES)膳食晚期糖基化终末产物与老年人心脏代谢疾病风险：基于2007-2021年韩国国家健康与营养调查的横断面数据DOI: 10.1186/s40795-026-01334-z
Frontiers in public health IF: 03.400Volume 14, Issue No.222Comprehensive assessment of health disparities in tribal and non-tribal population in India: a sex- and age-stratified cross-sectional study印度部落与非部落人群健康差异的综合评估：一项按性别和年龄分层的横断面研究DOI: 10.3389/fpubh.2026.1772205
Current drug metabolism IF: 01.800Ahead of Print.No.223Formulation and Characterization of CCD-based Optimized Geraniol-loaded Antidiabetic Niosomes基于CCD优化的香叶醇负载抗糖尿病囊泡的制备与表征DOI: 10.2174/0113892002382359251122043509
Immunopharmacol Immunotoxicol IF: 03.000Ahead of Print.No.224Investigation of the nitric oxide signaling pathway induced by ezetimibe on renal injury in streptozotocin-induced diabetic rat: role of anti-oxidative and anti-inflammatory effects依折麦布诱导一氧化氮信号通路对链脲佐菌素诱导的糖尿病大鼠肾损伤的作用：抗氧化和抗炎效应的研究DOI: 10.1080/08923973.2026.2657952
Critical care IF: 09.300Volume 30, Issue 1No.225Interpreting metformin safety: the importance of context, selection, and monitoring解读二甲双胍安全性：背景、选择与监测的重要性DOI: 10.1186/s13054-026-06050-5
Curēus IF: 01.300Volume 18, Issue 3No.226THR-β Agonists vs Incretin Therapies for Noncirrhotic Metabolic Dysfunction-Associated Steatohepatitis (MASH): A Biopsy-Anchored Systematic Review With Grading of Recommendations Assessment, Development and Evaluation (GRADE) CertaintyTHR-β激动剂与肠促胰素疗法治疗非肝硬化性代谢功能障碍相关脂肪性肝炎：一项基于活检的系统评价与GRADE证据确定性评估DOI: 10.7759/cureus.106038
Caspian J Intern Med IF: 01.000Volume 17, Issue 1No.227Monocytes in HIV associated atherosclerosis: A review of pathogenesis and clinical implications单核细胞在HIV相关动脉粥样硬化中的作用：发病机制与临床意义综述DOI: 10.22088/cjim.17.1.1
Caspian J Intern Med IF: 01.000Volume 17, Issue 1No.228Investigating subclinical myocardial ischemia by measuring carotid intima-media thickness using Doppler Ultrasound in patients with acute cardiac ischemia通过多普勒超声测量颈动脉内膜中层厚度研究急性心肌缺血患者的亚临床心肌缺血DOI: 10.22088/cjim.17.1.97
Trials IF: 02.000Ahead of Print.No.229Optimizing metabolic management on integrase-based ART (OPTIMAR): study protocol for a 2 × 2 factorial, randomised, double-blind placebo-controlled trial to compare the addition of dapagliflozin versus placebo, and rosuvastatin plus ezetimibe versus pitavastatin, in people with HIV on integrase strand transfer inhibitor-based antiretroviral therapy with elevated metabolic risk优化基于整合酶的抗逆转录病毒治疗中的代谢管理（OPTIMAR）：一项2×2析因、随机、双盲、安慰剂对照试验方案，比较在具有高代谢风险的HIV感染者中加用达格列净与安慰剂，以及瑞舒伐他汀联合依折麦布与匹伐他汀的效果DOI: 10.1186/s13063-026-09723-2
RSC advances IF: 04.600Volume 16, Issue 24No.230Novel piperazine-triazole hybrids as PTP1B and alpha-amylase inhibitors: synthesis, biological evaluation and computational validation through network pharmacology, molecular docking, MD simulations, DFT and MMPBSA analysis新型哌嗪-三唑杂合物作为PTP1B和α-淀粉酶抑制剂：合成、生物学评价及通过网络药理学、分子对接、MD模拟、DFT和MMPBSA分析的计算验证DOI: 10.1039/d6ra00931j
Clinical Research in Cardiology IF: 03.700Ahead of Print.No.231Long-term prognosis of coexistent metabolic dysfunction–associated steatotic liver disease and chronic kidney disease following acute myocardial infarction急性心肌梗死后共存代谢功能障碍相关脂肪性肝病与慢性肾脏病的长期预后DOI: 10.1007/s00392-026-02925-3
JSCAIAhead of Print.No.232Expanding Anatomical Feasibility of CardioMEMS Implantation: A Case Report of Successful Implantation in a Patient With Significant Morbid Obesity扩展CardioMEMS植入的解剖可行性：一例重度肥胖患者成功植入的病例报告DOI: 10.1016/j.jscai.2026.105319
236
Diabetes Mellitus(DM)
糖尿病
93
Obesity
肥胖症
63
Insulin
胰岛素
27
Type 2 diabetes mellitus(T2DM)
2型糖尿病
14
Metabolic Syndrome
代谢综合征
14
Diabetic Foot
糖尿病足
12
Metformin
二甲双胍
11
Gestational Diabetes Mellitus(GDM)
妊娠糖尿病
11
Glucagon-Like Peptide-1 Receptor Agonists(GLP-1RA)
胰高血糖素样肽-1受体激动剂
11
Diabetic Retinopathy
糖尿病视网膜病
9
Diabetic Kidney Disease(DKD)
糖尿病肾脏病
8
Diabetic Neuropathies
糖尿病性神经病变
7
Semaglutide
司美格鲁肽
7
Hypoglycemic Agents
降糖药
5
Type 1 diabetes mellitus(T1DM)
1型糖尿病
5
Tirzepatide
替尔泊肽
5
Diabetes Complications
糖尿病并发症
5
Diabetic Peripheral Neuropathy(PDN)
糖尿病周围神经病变
4
Pregabalin
普瑞巴林
4
Dapagliflozin
达格列净
2
Ertugliflozin
艾托格列净
2
Sodium-Glucose Transporter 2 Inhibitors(SGLT-2i)
钠-葡萄糖协同转运蛋白2抑制剂
2
Liraglutide
利拉鲁肽
2
Sitagliptin
西他列汀
2
Gabapentin
加巴喷丁
2
Diabetic acidosis
糖尿病性酸中毒
2
Diabetic Cardiomyopathies
糖尿病心肌病
2
Painful Diabetic Peripheral Neuropathy(PDPN)
痛性糖尿病周围神经病变
1
gamma-Aminobutyric Acid(GABA)
γ-氨基丁酸
1
Canagliflozin
卡格列净
1
Dipeptidyl-Peptidase IV Inhibitors(DPP-4i)
二肽基肽酶-4抑制剂
1
Vildagliptin
维格列汀
编辑：韩玉莲
审校：韩玉莲
2026-04-29
·麦科奥特
MICOT
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抗凝逆转的“通用解药”
麦科奥特MT1011完成I期临床 剑指临床痛点
抗凝治疗是一把“双刃剑”——预防血栓的同时可能引发出血危机。全球每年新增15-45万严重出血患者，但现有逆转剂或因血栓风险撤市，或适应症狭窄。2026年4月17日，麦科奥特宣布其广谱抗凝逆转剂MT1011完成I期临床研究数据库锁定，安全性表现积极。
01 未被满足的临床需求
全球约4.23亿心血管疾病患者中，约1500万人使用新型口服抗凝药（NOACs）。然而，每种NOACs均有
颅内及胃肠道出血风险，按严重出血年发生率1%-3%计算，全球每年新增15-45万严重出血患者。
当前临床困境在于：唯一针对Xa因子抑制剂的逆转剂Andexanet alfa因30天血栓发生率约9.7%，已于2025年12月撤市；而Praxbind仅对达比加群酯有效，且为生物制剂、需冷藏、价格昂贵。临床亟需一款广谱、快速、安全的逆转剂——这正是麦科奥特MT1011瞄准的临床价值缺口。
02 MT1011：新型合成小分子广谱抗凝逆转剂
MT1011是麦科奥特研发的一款新型合成的、作用机制独特的小分子药物。由于其独特作用机制，可以拮抗抗凝药使其失去抗凝活性，从而快速重建正常凝血。
其核心优势为：
广谱性：初步考虑用于逆转Xa因子抑制剂（利伐沙班、阿哌沙班），未来有望覆盖更多抗凝药物
快速逆转：直接结合，无需体内酶参与
良好安全性：I期数据初步验证
非生物制剂：合成小分子，无免疫原性顾虑，储存运输便捷
注射用MT1011临床定位
大的外伤或抗凝剂过量
03 I期临床已完成：安全性信号积极
2026年4月17日，MT1011的I期临床研究完成数据库锁定。该项目在首都医科大学附属北京世纪坛医院（单中心）开展，顺利完成了方案拟定的5个剂量组的递增试验。安全性揭盲结果（试验药物组）未出现与药物相关的SAE。这一安全性轮廓为后续II期临床奠定了良好基础。
04 展望：加速推进II期
麦科奥特将携手研究团队，尽早推进II期临床。抗凝逆转领域仍存在巨大未被满足的需求，MT1011的I期成功给患者和医者带来新希望。这款“中国智造”能否成为紧急时刻的“通用解药”？我们期待II期临床给出答案。
MICOT
Universal Antidote for Anticoagulation Reversal: Micot's MT1011 Completes Phase I Clinical Trial, Targeting Unmet Clinical Needs
Anticoagulant therapy is a double-edged sword—preventing thrombosis while risking bleeding crises. With 150,000 to 450,000 new severe bleeding cases reported globally each year, existing reversal agents have either been withdrawn due to thrombotic risks or feature narrow indications. On April 17, 2026, Micot announced the successful database lock for the Phase I clinical study of MT1011, a broad-spectrum anticoagulant reversal agent, with favorable safety results.
01 Unmet Clinical Needs
Among approximately 423 million cardiovascular disease patients worldwide, around 15 million are treated with novel oral anticoagulants (NOACs). However, all NOACs carry bleeding risks. Based on a 1%-3% annual incidence of severe bleeding, there are 150,000 to 450,000 new severe bleeding cases globally each year.
The clinical dilemma: Andexanet alfa, the only reversal agent for factor Xa inhibitors, was withdrawn in December 2025 due to a 9.7% 30-day thrombosis rate. Praxbind only targets dabigatran and is a costly biological agent requiring refrigeration. There is an urgent need for a broad-spectrum, rapid, and safe reversal agent—precisely the unmet need MT1011 aims to address.
02 MT1011: Novel Synthetic Small-Molecule Broad-Spectrum Reversal Agent
MT1011 is a newly synthesized small-molecule drug with a unique mechanism of action developed by M. Thanks to its distinctive mechanism, it can antagonize anticoagulants to inactivate them and rapidly restore normal blood coagulation.
Core Advantages
Broad-spectrum property: Initially intended for reversing factor Xa inhibitors (rivaroxaban, apixaban), and it is expected to cover more anticoagulant drugs in the future.
Rapid reversal: direct combination without the involvement of endogenous enzymes.
Favorable Safety Profile: Preliminary Validation from Phase I Data.
Non-biological agents: synthetic small molecules, no immunogenicity concerns, convenient storage and transportation.
Clinical Positioning of MT1011 for injection
Major trauma or anticoagulant overdose
03 Phase I Completed with Positive Safety Signals
On April 17, 2026, the Phase I clinical study of MT1011 completed database lock. This study was conducted at Beijing Shijitan Hospital, Capital Medical University (single center), and successfully completed the dose-escalation trial of five dose groups as specified in the protocol. According to the unblinded safety results of the investigational drug group, with no drug-related serious adverse events (SAEs) reported. This favorable safety profile lays a solid foundation for the subsequent Phase II clinical trial.
04 Outlook: Accelerating Phase II
Micot will collaborate with the research team to advance the Phase II clinical study as soon as possible. Significant unmet needs remain in the anticoagulation reversal field. The successful Phase I completion of MT1011 brings new hope to patients and clinicians. Can this domestically innovated product truly serve as a universal antidote in emergency situations? Phase II will provide the answer.
MICOT
临床1期临床2期
100 项与 甲磺酸达比加群酯 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 复发性深静脉血栓形成 | 欧盟 | 2024-02-19 | |
| 复发性深静脉血栓形成 | 冰岛 | 2024-02-19 | |
| 复发性深静脉血栓形成 | 列支敦士登 | 2024-02-19 | |
| 复发性深静脉血栓形成 | 挪威 | 2024-02-19 | |
| 全身性栓塞 | 澳大利亚 | 2008-11-24 | |
| 心房颤动 | 欧盟 | 2008-03-17 | |
| 心房颤动 | 冰岛 | 2008-03-17 | |
| 心房颤动 | 列支敦士登 | 2008-03-17 | |
| 心房颤动 | 挪威 | 2008-03-17 | |
| 栓塞 | 欧盟 | 2008-03-17 | |
| 栓塞 | 冰岛 | 2008-03-17 | |
| 栓塞 | 列支敦士登 | 2008-03-17 | |
| 栓塞 | 挪威 | 2008-03-17 | |
| 肺栓塞 | 欧盟 | 2008-03-17 | |
| 肺栓塞 | 冰岛 | 2008-03-17 | |
| 肺栓塞 | 列支敦士登 | 2008-03-17 | |
| 肺栓塞 | 挪威 | 2008-03-17 | |
| 脑卒中 | 欧盟 | 2008-03-17 | |
| 脑卒中 | 冰岛 | 2008-03-17 | |
| 脑卒中 | 列支敦士登 | 2008-03-17 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 脑静脉血栓形成 | 临床3期 | 法国 | 2016-12-13 | |
| 脑静脉血栓形成 | 临床3期 | 德国 | 2016-12-13 | |
| 脑静脉血栓形成 | 临床3期 | 印度 | 2016-12-13 | |
| 脑静脉血栓形成 | 临床3期 | 意大利 | 2016-12-13 | |
| 脑静脉血栓形成 | 临床3期 | 荷兰 | 2016-12-13 | |
| 脑静脉血栓形成 | 临床3期 | 波兰 | 2016-12-13 | |
| 脑静脉血栓形成 | 临床3期 | 葡萄牙 | 2016-12-13 | |
| 脑静脉血栓形成 | 临床3期 | 俄罗斯 | 2016-12-13 | |
| 脑静脉血栓形成 | 临床3期 | 西班牙 | 2016-12-13 | |
| 栓塞性中风 | 临床3期 | 美国 | 2014-11-27 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
| 研究 | 分期 | 人群特征 | 评价人数 | 分组 | 结果 | 评价 | 发布日期 |
|---|
临床1期 | - | 32 | Dabigatran-etexilate (Dabigatran-etexilate (R)) | 鬱夢遞襯膚蓋衊顧廠鑰(鏇醖顧構蓋鹹糧窪簾夢) = 顧簾衊鏇糧憲繭製齋窪 範齋襯鑰製壓壓鹹艱願 (艱顧襯網膚製餘鬱築艱, NA) 更多 | - | 2026-01-09 | |
(Zongertinib and dabigatran-etexilate (T)) | 鬱夢遞襯膚蓋衊顧廠鑰(鏇醖顧構蓋鹹糧窪簾夢) = 蓋窪襯壓願憲襯壓襯願 範齋襯鑰製壓壓鹹艱願 (艱顧襯網膚製餘鬱築艱, NA) 更多 | ||||||
临床4期 | 540 | 壓製鬱壓觸鑰窪襯蓋觸(簾廠憲夢蓋鏇窪齋蓋網) = 窪繭鏇齋鬱憲選糧選憲 膚廠艱糧顧鹽淵廠選鏇 (願醖網願鹽選艱壓願窪 ) 更多 | 不佳 | 2025-11-18 | |||
壓製鬱壓觸鑰窪襯蓋觸(簾廠憲夢蓋鏇窪齋蓋網) = 淵築構繭糧淵艱簾齋觸 膚廠艱糧顧鹽淵廠選鏇 (願醖網願鹽選艱壓願窪 ) 更多 | |||||||
N/A | 873 | (Advanced educational intervention) | 觸選觸衊淵廠選簾蓋憲(範選廠遞餘簾顧顧齋淵) = 遞夢衊鏇鏇夢遞鏇艱鹹 願選鏇築繭糧餘衊餘範 (憲鬱醖齋衊構範淵齋淵 ) | 积极 | 2025-10-01 | ||
(Standard care) | 觸選觸衊淵廠選簾蓋憲(範選廠遞餘簾顧顧齋淵) = 蓋積繭糧夢遞範憲鑰網 願選鏇築繭糧餘衊餘範 (憲鬱醖齋衊構範淵齋淵 ) | ||||||
临床4期 | 100 | 憲淵糧憲簾窪艱艱構獵 = 繭築簾獵醖糧糧簾鏇繭 鹽艱鹽鏇簾築醖艱鑰齋 (襯願鹹夢衊鑰範齋齋鑰, 齋膚齋積夢構鬱夢壓鬱 ~ 淵構選廠顧網醖蓋膚網) 更多 | - | 2025-06-10 | |||
临床1期 | - | 26 | (Rosuvastatin (Part 1, Reference 1)) | 餘憲選築壓醖壓艱築艱(鬱製簾衊膚構餘糧廠顧) = 醖衊鬱齋願範餘襯觸鏇 鹹糧淵廠鏇構襯願窪憲 (觸鹹窪觸糧窪衊糧鹹網, 1.13) 更多 | - | 2025-02-27 | |
(Rosuvastatin + BI 1358894 (Part 1, Test 1)) | 餘憲選築壓醖壓艱築艱(鬱製簾衊膚構餘糧廠顧) = 製顧網鏇網簾簾廠觸構 鹹糧淵廠鏇構襯願窪憲 (觸鹹窪觸糧窪衊糧鹹網, 1.13) 更多 | ||||||
临床1期 | 16 | DE (Period 1: DE 150 mg) | 願蓋衊憲築築築積獵齋(壓餘選淵襯範壓積範網) = 觸願鑰範顧範網糧範廠 鹽簾餘鹽夢醖製醖遞襯 (窪鬱襯簾憲餘構顧製鹹, 43) 更多 | - | 2024-11-15 | ||
DE+PF-07081532 (Period 4: DE 150 mg + PF-07081532 80 mg QD) | 願蓋衊憲築築築積獵齋(壓餘選淵襯範壓積範網) = 餘糧膚壓窪繭顧夢糧顧 鹽簾餘鹽夢醖製醖遞襯 (窪鬱襯簾憲餘構顧製鹹, 38) 更多 | ||||||
N/A | 371 | DOACs (AF) | 蓋醖鹽壓網積觸構鏇齋(夢鏇鬱衊醖獵鹹繭蓋築) = 蓋願鹹夢餘艱廠餘艱網 鬱遞鑰繭築醖鏇製淵壓 (膚鑰鬱膚繭簾壓憲醖醖 ) 更多 | 积极 | 2024-06-22 | ||
DOACs (VTE) | 蓋醖鹽壓網積觸構鏇齋(夢鏇鬱衊醖獵鹹繭蓋築) = 製艱淵憲鏇膚壓構顧願 鬱遞鑰繭築醖鏇製淵壓 (膚鑰鬱膚繭簾壓憲醖醖 ) 更多 | ||||||
N/A | - | Vitamin K antagonist (VKA) | 醖顧廠窪鏇憲獵遞醖築(壓範襯壓築範鹽願醖範) = Switching from a VKA to a NOAC in frail older patients with AF was associated with an increased risk of bleeding, yet without any effect on overall and different domains of QoL. 淵築鬱願鏇鹹獵夢衊醖 (構鑰淵遞遞鏇積齋齋糧 ) | 不佳 | 2024-04-08 | ||
Non-Vitamin K antagonist oral anticoagulant (NOAC) | |||||||
临床1期 | - | 28 | (Rosuvastatin (Part 1, Reference 1)) | 構構襯憲壓獵積構鏇衊(繭願醖鏇襯鏇憲衊憲鬱) = 願鑰繭鹽顧鹽齋築獵淵 襯簾顧網衊壓餘鹽築願 (積構遞糧膚淵衊廠獵衊, NA) 更多 | - | 2024-02-23 | |
(Rosuvastatin + BI 1323495 (Part 1, Test 1)) | 構構襯憲壓獵積構鏇衊(繭願醖鏇襯鏇憲衊憲鬱) = 蓋積艱艱鬱壓糧繭願廠 襯簾顧網衊壓餘鹽築願 (積構遞糧膚淵衊廠獵衊, NA) 更多 | ||||||
临床3期 | - | 壓鹹鑰壓夢蓋製選遞夢(鹹夢鏇蓋築選齋襯遞淵) = 膚網餘築製鏇窪構窪鬱 夢夢積遞簾觸鏇鹹範獵 (齋遞窪鑰齋鑰鏇鏇製蓋, 0.08 ~ 1.23) | 积极 | 2024-02-20 | |||
(Standard of care) | 製繭觸衊網簾鹽築鑰範(製繭窪膚獵淵窪夢獵夢) = 遞淵鹽壓齋蓋膚範顧願 鏇壓糧鏇獵憲獵糧選製 (壓衊願鏇簾齋觸衊顧蓋 ) 更多 |
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