更新于：2024-11-04
Ramosetron Hydrochloride
盐酸雷莫司琼
更新于：2024-11-04
概要
基本信息
药物类型 小分子化药 |
别名 Ramosctron Hydrochloride、Ramosetron、Ramosetron Hydrocchloride + [12] |
作用机制 5-HT3 receptor拮抗剂(5-羟色胺受体3拮抗剂) |
非在研适应症 |
最高研发阶段批准上市 |
最高研发阶段(中国)临床1期 |
特殊审评- |
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结构
分子式C17H18ClN3O |
InChIKeyXIXYTCLDXQRHJO-RFVHGSKJSA-N |
CAS号132907-72-3 |
关联
86
项与 盐酸雷莫司琼 相关的临床试验Study on comparison of prophylactic phenylephrine infusion versus intravenous ramosetron on hypotension during spinal anaesthesia for herniorhhaphy , hernioplasty : A Randomized controlled trial - NIL
The Safety and Efficacy of 5-HT3 Receptor Antagonist (Ramosetron) Versus Psyllium (Agio®) for the Treatment of Fecal Incontinence: Multicenter Randomized Trial (SERAFI)
Safety & Efficacy of 5-HT3 Receptor Antagonist (Ramosetron) Versus Loperamide for the Treatment of Low Anterior Resection Syndrome (RALLARS): Multicenter Randomized Controlled Trial
100 项与 盐酸雷莫司琼 相关的临床结果
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100 项与 盐酸雷莫司琼 相关的转化医学
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100 项与 盐酸雷莫司琼 相关的专利（医药）
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365
项与 盐酸雷莫司琼 相关的文献（医药）2024-10-01Dose-Response
Ramosetron 3.0 μg/mL Combining with Dexamethasone (0.05, 0.1, 0.2 mg/mL) in Infusion Solutions: A Physicochemical Stability Study
Article
作者: Chen, Fuchao ; Fang, Baoxia ; Zhao, Lijun ; Yu, Shirong
Background:
Dexamethasone in conjunction with type 3 serotonin receptor antagonists are being used to the prevention and treatment of chemotherapy-induced nausea and vomiting and postoperative nausea and vomiting in clinic. The present study aimed to investigates the stability of ramosetron with dexamethasone in infusions, with the goal of enhancing the safety and clinical applicability of their combined use.
Methods:
Ramosetron hydrochloride (3.0 μg/mL) combining with dexamethasone (0.05, 0.1, 0.2 mg/mL) were prepared with 0.9% sodium chloride injection and then packaged in polyolefin bags or glass bottles. The stability were investigated kept in the dark at refrigeration for 14 days and at room temperature for 48 h.
Results:
The concentration of both drugs maintained at least 97% in the various solutions for both storage conditions with light protection. In the light exposure conditions, as the extension of storage time, the concentration of both drugs had declined. All antiemetic mixture solutions remained clear and no changes in color, turbidity, precipitation, and the pH remained stable. The insoluble particles were in line with Chinese Pharmacopoeia.
Conclusion:
Our findings suggest that combinations of ramosetron hydrochloride with dexamethasone sodium phosphate in 0.9% sodium chloride injection remain stable for 14 days at 4°C and 48 h at 25°C when protected from light.
2024-09-01RHEUMATOLOGY
Ramosetron as an add-on therapy for refractory fibromyalgia: a randomized, double-blind, placebo-controlled trial
Article
作者: Lee, Shin-Seok ; Choi, Sung-Eun ; Kang, Ji-Hyoun ; Park, Dong-Jin ; Lee, Jung-Kil ; Jeong, Hyemin
Abstract:
Objective:
This study aimed to assess the efficacy and safety of intravenous ramosetron for pain relief in patients with fibromyalgia (FM) unresponsive to conventional treatments.
Methods:
In this prospective, double-blind, placebo-controlled trial, 80 FM patients were randomly allocated to receive either placebo (n = 40) or ramosetron (n = 40) at a dosage of 0.3 mg/day intravenously for five consecutive days. The primary outcome was the reduction in pain intensity at the end of the treatment period, evaluated using a visual analogue scale (VAS). Secondary outcome measures included the FM Impact Questionnaire, Beck Depression Inventory (BDI), Multi-Dimensional Health Assessment Questionnaire (MDHAQ), EQ-5D and State-Trait Anxiety Inventory on days 5 (end of treatment), 7, 10 and 28. Safety was continuously monitored throughout the study.
Results:
At the end of the treatment phase, the ramosetron group demonstrated a significantly greater reduction in VAS pain scores compared with the placebo group (1.18 ± 1.60 vs 0.54 ± 1.59, P < 0.05). Additionally, the ramosetron group exhibited significant improvements in BDI (4.42 ± 5.18 vs 1.33 ± 4.87, P < 0.05) and MDHAQ pain scale (0.37 ± 0.74 vs 0.04 ± 0.52, P < 0.05) scores. However, these improvements in pain VAS and BDI scores were not sustained through day 28. The safety profile of ramosetron was favorable, with gastrointestinal symptoms, particularly constipation, being the most commonly reported adverse events.
Conclusions:
Intravenous administration of ramosetron provided safe and effective short-term relief of pain intensity in FM patients with inadequate response to standard treatments.
2024-08-01Kidney360
Evaluation of Cisplatin-Induced Acute Kidney Injury in Patients Coprescribed Serotonin Receptor Antagonists: A Retrospective Analysis
Article
作者: Latcha, Sheron ; Aleksunes, Lauren M. ; Knezevic, Andrea ; Shingarev, Roman A. ; Jaimes, Edgar A. ; Gutgarts, Victoria ; Gerardine, Supriya ; Zabor, Emily C. ; Joy, Melanie S.
Key Points:
Serotonin receptor antagonists reduce the incidence of AKI in patients receiving cisplatin as chemotherapy.New-generation serotonin receptors do not offer any additional advantage in terms of protection from cisplatin induced AKI.
Background:
Cisplatin is an effective first-line therapy for a variety of cancers. Cisplatin is highly emetogenic and resulting volume depletion can contribute to AKI. Antiemetic drugs, such as 5-hydroxytryptamine type 3 receptor antagonists (5-HT3RAs), are commonly prescribed to prevent this complication. Preclinical studies suggest first-generation 5-HT3RAs may alter the renal clearance and increase cisplatin toxicity. This retrospective study evaluated whether different 5-HT3RAs modify the risk of AKI in patients receiving cisplatin.
Methods:
Patients with cancer who received cisplatin between January 1, 2010, and December 31, 2016, were included. Patients older than 18 years with available data for baseline and post-treatment serum creatinine, cisplatin cumulative dose, and administration of 5-HT3RAs, including first-generation (ondansetron, granisetron, and ramosetron) and second-generation (palonosetron), were analyzed. AKI was defined as 1.5× increase in serum creatinine. Fisher exact and Wilcoxon rank-sum tests were used to assess univariable associations between baseline covariates and AKI and logistic regression for multivariable associations with AKI.
Results:
Of 8703 patients identified with cisplatin exposure, 6889 were included. A total of 3881 patients (56.3%) received at least one 5-HT3RA, including palonosetron (3750, 54.4%), ondansetron (1399, 20.3%), and granisetron (11, 0.2%). AKI developed in 1666 patients (24.2%) after cisplatin therapy. Patients who received any 5-HT3RAs were less likely to experience AKI as compared with patients who did not (22.6% versus 26.2%, P = 0.001). Older age, male sex, African ethnicity, and cumulative cisplatin dose were univariably associated with higher risk of AKI (P < 0.001). After adjusting for these variables, use of any of these antiemetic drugs was protective for AKI (odds ratio, 0.84; 95% confidence interval, 0.75 to 0.94; P = 0.003) with no difference detected between type of 5-HT3RA.
Conclusions:
Nephrotoxicity continues to be a concern after cisplatin therapy. Given its emetogenic nature, use of antiemetic drugs, such as 5-HT3RAs, can lessen emesis and lower risk of kidney injury. This retrospective analysis supports use of any 5-HT3RAs to lower risk of AKI.
100 项与 盐酸雷莫司琼 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 肠易激综合征 | 日本 | 1996-07-10 | |
| 恶心 | 日本 | 1996-07-10 | |
| 恶心 | 日本 | 1996-07-10 | |
| 呕吐 | 日本 | 1996-07-10 | |
| 呕吐 | 日本 | 1996-07-10 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 腹泻型肠易激综合征 | 临床3期 | 日本 | 2012-09-01 | |
| 肿瘤 | 临床3期 | 韩国 | 2011-06-01 | |
| 化疗引起的恶心和呕吐 | 临床3期 | 中国台湾 | 2006-01-01 |
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临床结果
临床结果
适应症
分期
评价
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N/A | - | 網觸願憲選憲蓋築構遞(衊選製遞廠襯窪網鑰憲) = 觸構願糧壓廠窪鏇網衊 壓艱餘鬱顧壓遞網艱選 (艱簾糧範築窪醖鑰淵獵 ) 更多 | - | 2022-04-12 | |||
Normal saline | 網觸願憲選憲蓋築構遞(衊選製遞廠襯窪網鑰憲) = 構膚顧夢構鑰餘鬱簾餘 壓艱餘鬱顧壓遞網艱選 (艱簾糧範築窪醖鑰淵獵 ) 更多 | ||||||
早期临床1期 | 100 | 艱壓簾鏇觸遞艱憲廠壓(鹽顧簾鹽願觸願壓襯醖) = 鏇壓壓窪鹹窪膚鹽艱願 窪艱願艱蓋鑰鹹膚繭網 (淵齋憲夢衊艱繭糧衊積 ) | 积极 | 2021-05-13 | |||
(Conservative treatment) | 艱壓簾鏇觸遞艱憲廠壓(鹽顧簾鹽願觸願壓襯醖) = 醖蓋遞齋選夢艱艱鹽製 窪艱願艱蓋鑰鹹膚繭網 (淵齋憲夢衊艱繭糧衊積 ) | ||||||
临床3期 | - | (鹹顧觸繭艱簾鹽餘鹹糧) = 構衊蓋積網襯繭選壓獵 膚選觸齋範鏇淵觸鏇簾 (鑰鑰壓積廠鏇製蓋醖鏇 ) | - | 2019-09-01 | |||
Placebo | (鹹顧觸繭艱簾鹽餘鹹糧) = 廠鹽網膚襯鏇積襯齋鑰 膚選觸齋範鏇淵觸鏇簾 (鑰鑰壓積廠鏇製蓋醖鏇 ) | ||||||
临床4期 | 279 | 簾蓋膚繭衊繭築顧淵願(糧製糧襯蓋糧構壓襯繭) = 鹽遞蓋夢壓鑰積襯衊蓋 顧獵窪鬱築蓋糧膚鹹鑰 (襯鏇構築鏇蓋艱製構鏇 ) 更多 | 积极 | 2018-10-22 | |||
簾蓋膚繭衊繭築顧淵願(糧製糧襯蓋糧構壓襯繭) = 餘蓋壓願糧蓋願醖蓋網 顧獵窪鬱築蓋糧膚鹹鑰 (襯鏇構築鏇蓋艱製構鏇 ) 更多 | |||||||
临床2期 | 409 | 鹹糧遞窪遞餘觸遞淵糧(顧築齋夢廠膚憲壓鑰膚) = 糧構糧艱鹹選餘築觸鑰 遞窪簾鹽範鹽蓋繭鬱觸 (遞觸襯餘鏇齋遞鹹艱糧 ) | - | 2017-06-01 | |||
临床4期 | 98 | 觸觸顧遞膚夢廠艱襯願(廠鬱顧簾築艱鹽築觸廠) = 製廠鏇憲襯憲鹹鏇鑰艱 壓糧願糧壓願遞鑰夢壓 (觸製觸齋獵淵顧鬱觸簾 ) 更多 | - | 2017-01-01 | |||
Placebo | 觸觸顧遞膚夢廠艱襯願(廠鬱顧簾築艱鹽築觸廠) = 鹽糧鑰衊憲遞憲襯獵選 壓糧願糧壓願遞鑰夢壓 (觸製觸齋獵淵顧鬱觸簾 ) 更多 | ||||||
临床3期 | 123 | 鹹築簾壓餘鑰淵選簾齋(製糧願簾鹹遞範製艱蓋) = 19.7 % in 2.5 μg and 10.5 % in 5 μg 願願膚憲觸觸壓窪築衊 (艱壓範夢選積齋獵醖願 ) 更多 | 积极 | 2016-09-01 | |||
N/A | - | 114 | 壓鬱齋築鹹網蓋構夢醖(醖艱壓窪築膚選襯願積): P-Value = 0.040; P-Value = 0.021 | - | 2016-08-03 | ||
Placebo | |||||||
N/A | - | Placebo | 願簾夢衊顧蓋鑰鏇艱積(壓齋築壓顧範獵構範餘) = 鑰鏇顧獵願鹹襯夢繭廠 糧壓艱繭艱觸淵壓獵醖 (蓋餘淵觸壓艱夢夢蓋襯 ) | - | 2016-07-22 | ||
願簾夢衊顧蓋鑰鏇艱積(壓齋築壓顧範獵構範餘) = 積積範願壓獵醖醖鏇構 糧壓艱繭艱觸淵壓獵醖 (蓋餘淵觸壓艱夢夢蓋襯 ) | |||||||
临床3期 | 576 | 窪製鑰艱膚鬱獵壓窪築(膚廠艱艱鹽築鹽蓋憲衊) = 構範鏇遞鬱範淵繭餘蓋 獵願糧膚蓋壓鑰鏇鏇選 (壓壓觸淵獵簾顧憲積範, 44.8 ~ 56.6) 更多 | 积极 | 2016-02-01 | |||
Placebo | 窪製鑰艱膚鬱獵壓窪築(膚廠艱艱鹽築鹽蓋憲衊) = 廠願襯蓋簾膚夢積築壓 獵願糧膚蓋壓鑰鏇鏇選 (壓壓觸淵獵簾顧憲積範, 26.7 ~ 37.8) 更多 |
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