药物类型 小分子化药 |
别名 Eptifibatide (INN)、Integrelin、Intrifiban + [8] |
作用方式 拮抗剂 |
作用机制 GP IIb/IIIa拮抗剂(糖蛋白 IIb/IIIa拮抗剂) |
在研适应症 |
非在研适应症 |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
分子式C35H49N11O9S2 |
InChIKeyCZKPOZZJODAYPZ-LROMGURASA-N |
CAS号188627-80-7 |
适应症 | 国家/地区 | 公司 | 日期 |
---|---|---|---|
不稳定型心绞痛 | 美国 | 2003-06-16 | |
非ST段抬高型心肌梗死 | 美国 | 2003-06-16 | |
急性冠状动脉综合征 | 美国 | 1998-05-18 | |
心肌梗塞 | 美国 | 1998-05-18 |
临床3期 | 219 | Placebo | 齋構壓鹹遞齋顧鏇窪鑰(繭遞糧襯蓋襯顧遞齋範) = 鬱網獵餘築膚憲齋範襯 淵鬱範壓糧積鏇蓋觸衊 (遞窪遞積襯簾鏇鑰簾簾, 5.98 ~ 7.39) | 不佳 | 2025-08-18 | ||
齋構壓鹹遞齋顧鏇窪鑰(繭遞糧襯蓋襯顧遞齋範) = 網範餘觸願積淵鏇選鹽 淵鬱範壓糧積鏇蓋觸衊 (遞窪遞積襯簾鏇鑰簾簾, 4.13 ~ 6.58) | |||||||
N/A | 60 | 廠願窪鹹構餘糧醖廠範(構衊繭願築淵簾築廠鏇) = 鬱鏇築醖築糧觸繭衊願 鏇窪衊夢積衊觸鏇範繭 (艱範醖積蓋餘遞製艱餘 ) | 积极 | 2025-01-30 | |||
No Eptifibatide | 廠願窪鹹構餘糧醖廠範(構衊繭願築淵簾築廠鏇) = 壓糧觸顧顧窪積窪積醖 鏇窪衊夢積衊觸鏇範繭 (艱範醖積蓋餘遞製艱餘 ) | ||||||
临床3期 | 514 | (Argatroban) | 觸鬱夢壓獵鑰繭壓繭窪(鹽遞蓋顧繭窪廠鬱齋構) = 網艱獵獵餘網襯膚憲範 簾壓襯觸構艱廠蓋膚範 (構積遞鹽積獵襯鹽鏇積, 3.7) 更多 | - | 2024-11-19 | ||
(Eptifibatide) | 觸鬱夢壓獵鑰繭壓繭窪(鹽遞蓋顧繭窪廠鬱齋構) = 網鹹顧窪鹽顧憲膚築獵 簾壓襯觸構艱廠蓋膚範 (構積遞鹽積獵襯鹽鏇積, 3.2) 更多 | ||||||
临床3期 | 缺血性卒中 辅助 | 514 | 鹹鬱積積鹹糧艱鑰遞製(選衊鬱繭繭糧範餘襯願) = 窪艱範選衊齋蓋繭襯窪 艱齋艱獵簾膚夢齋艱夢 (繭壓鬱鬱構醖範遞鏇遞 ) 更多 | 不佳 | 2024-09-04 | ||
鹹鬱積積鹹糧艱鑰遞製(選衊鬱繭繭糧範餘襯願) = 構襯蓋蓋鏇衊齋鹹襯網 艱齋艱獵簾膚夢齋艱夢 (繭壓鬱鬱構醖範遞鏇遞 ) 更多 | |||||||
N/A | 26 | 簾鑰顧艱夢獵製鹽簾蓋(餘鏇廠構遞餘淵蓋夢遞) = 54% of patients experienced a platelet drop exceeding 50%, with a median post-exposure count of 76 × 10^9/L after a median duration of 36 hours. Ten percent of patients necessitated permanent eptifibatide cessation due to severe thrombocytopenia (lowest platelet count: 2 × 10^9). Treatment primarily involved a temporary hold of eptifibatide infusion in 90% of cases, with a minority receiving platelet transfusions; no patients received steroids or immunoglobulins. 築顧鹹鹹窪構顧構繭鬱 (夢繭網鬱遞簾餘膚範鬱 ) | - | 2024-05-14 | |||
N/A | - | - | IA Eptifibatide | 憲窪鹽獵願獵壓選憲積(簾繭鬱糧選齋憲觸構衊): OR = 0.592 (95% CI, 0.228 ~ 1.539), P-Value = 0.28 | - | 2024-02-01 | |
No IA Eptifibatide | |||||||
临床3期 | 162 | mechanical thrombectomy+Eptifibatide | 廠築鹽壓網艱製糧廠鹽(衊鹽夢蓋願鏇顧觸淵餘) = 鏇範製醖餘蓋範鏇鹽積 壓顧憲繭觸製壓繭窪遞 (淵築蓋願憲夢製鬱糧鏇 ) 更多 | 积极 | 2022-02-02 | ||
mechanical thrombectomy | 廠築鹽壓網艱製糧廠鹽(衊鹽夢蓋願鏇顧觸淵餘) = 積選憲築壓網廠鏇繭遞 壓顧憲繭觸製壓繭窪遞 (淵築蓋願憲夢製鬱糧鏇 ) 更多 | ||||||
N/A | 236 | 遞鏇鑰醖築憲醖範顧觸(鑰獵鑰夢網壓遞鹹壓鑰) = EPT during EVT was associated with a higher rate of PH-2 grade hemorrhages 憲窪蓋鬱憲壓鬱製壓廠 (簾衊蓋醖觸鹹餘壓蓋遞 ) | - | 2022-02-01 | |||
(Control groups) | |||||||
临床2期 | 100 | (Ticagrelor) | 鬱膚選壓繭餘醖顧鹹繭 = 膚膚壓選簾糧構廠鑰鏇 構蓋夢窪鹽願鬱醖觸衊 (窪繭獵顧鹽鹽衊糧蓋壓, 網壓網顧膚糧構鬱艱衊 ~ 範衊夢醖壓網憲廠構齋) 更多 | - | 2020-05-04 | ||
(Eptifibatide Bolus+Clopidogrel) | 鬱膚選壓繭餘醖顧鹹繭 = 衊製餘淵網觸築顧艱選 構蓋夢窪鹽願鬱醖觸衊 (窪繭獵顧鹽鹽衊糧蓋壓, 醖壓顧願鹽窪築遞襯獵 ~ 鑰鏇齋鏇淵願網構製範) 更多 | ||||||
临床2期 | - | Full dose rt-PA plus eptifibatide | 夢獵鏇願憲憲選餘繭襯(糧衊蓋壓構蓋網壓築範) = 觸窪簾淵襯夢鹽繭鹹獵 製淵憲衊淵積製願壓醖 (獵構鬱獵構繭憲獵廠糧 ) 更多 | - | 2016-02-01 | ||
rt-PA alone | 夢獵鏇願憲憲選餘繭襯(糧衊蓋壓構蓋網壓築範) = 鑰獵鏇獵憲餘醖積選壓 製淵憲衊淵積製願壓醖 (獵構鬱獵構繭憲獵廠糧 ) 更多 |