IMM-101

Josefine Roemmler-Zehrer, former Medical Director at Ipsen & Celgene, brings broad global clinical and medical affairs expertiseAdding further oncology experience to Immodulon’s leadership team as the company prepares to advance IMM-101 into a pivotal trial in pancreatic cancer Uxbridge, UK – 5 June 2023 – Immodulon, a late-stage clinical company developing a highly differentiated cancer immunotherapy that primes the patient’s own innate immune system, today announces it has appointed Dr Josefine Roemmler-Zehrer, Associate Professor as Chief Medical Officer. She brings a significant track record of clinical and medical affairs success to Immodulon at a key time as the company prepares to advance IMM-101 into a pivotal trial in pancreatic cancer. “I am delighted to welcome incoming Josefine to the new leadership team at Immodulon as we prepare to advance our lead asset IMM-101 into a pivotal trial, said Gertjan Bartlema, Chief Executive Officer of Immodulon. “Josefine brings a wealth of global experience in clinical and medical affairs from leading pharmaceutical companies and will be instrumental in our efforts to unlock the full potential of IMM-101. We look forward to benefitting from Josefine’s insights and leadership as we finalise the design of our pivotal trial in pancreatic cancer and advance our mission to improve the lives of patients suffering from this difficult to treat cancer.” Josefine Roemmler-Zehrer, MD, Associate Professor, Chief Medical Officer added “I am so pleased to be joining Immodulon at this pivotal time in the company’s development. I have been excited and inspired by the new management’s energy and commitment to bring IMM-101, a new, transformative, broad spectrum immunotherapy to patients with pancreatic cancer. Pancreatic cancer has the highest mortality of any solid tumour and patients have few meaningful treatment options. I believe that IMM-101 can make a major contribution in addressing this fatal disease.” Josefine Roemmler-Zehrer brings significant experience in drug development and medical affairs to Immodulon having held senior leadership roles at leading pharmaceutical companies including Celgene, Amgen and Ipsen. Josefine has a proven track record of success in several product development programmes including Celgene’s Abraxane (nab-paclitaxel) in pancreatic cancer and NSCLC and Ipsen’s Cabometyx in renal cell carcinoma and thyroid cancer. She has led multi-disciplinary teams in a range of therapeutic areas including Oncology, Inflammation, Rheumatology, Dermatology, Neurology and Rare diseases. Josefine Roemmler-Zehrer started her medical training at the Semmelweis Egyetem University in Budapest and at the University of Julius Maximilians University Wurzburg, Germany, were she received her board certification in Human Medicine. After this she began her career at the University of Munich where she acquired her specialisation in Internal Medicine, Endocrinology and Diabetes and her postdoctoral lecture qualification. -Ends - Notes to Editors About Immodulon Therapeutics LtdImmodulon is a late-stage clinical company developing a highly differentiated cancer immunotherapy approach that primes the patient’s own innate immune system with the aim to significantly enhance the efficacy of a broad range of anti-cancer therapies, including chemotherapy and checkpoint inhibitors. Immodulon is developing IMM-101, a heat-killed formulation of the mycobacterium M. obuense, as a broad-spectrum immunomodulatory agent that has promising potential in a range of difficult-to-treat tumours including those considered to be immunologically “cold,” such as pancreatic ductal adenocarcinoma (PDAC). Immodulon has generated promising, positive Phase 2 data with IMM-101 in pancreatic cancer in combination with gemcitabine. These data show that IMM-101 is safe and effective, prolonging progression-free survival for a sub-group of patients with metastatic disease compared to gemcitabine alone. IMM-101 is due to enter a pivotal pancreatic cancer study. Contacts: ImmodulonGertjan Bartlema, CEOG.Bartlema@immodulon.comPeter Greaney, CBOP.Greaney@immodulon.com MEDiSTRAVA ConsultingFrazer Hall, Sandi Greenwood, Eleanor Perkin Immodulon@medistrava.com +44 (0)203 928 6900

Richard Davies, Deputy Chairman of Alvotech, elected as Chairman of the BoardGertjan Bartlema, formerly at Celgene and Amgen, appointed as Chief Executive OfficerPeter Greaney, formerly at ADC Therapeutics and Celgene, appointed as Chief Business OfficerAppointments add significant industry experience to accelerate development of lead asset IMM-101 and bring it to patients in need of effective therapies Uxbridge, UK – 10 May 2023 – Immodulon, a late-stage clinical company developing a highly differentiated cancer immunotherapy that primes the patient’s own innate immune system, today announces it has elected Richard Davies as Chairman of the Board and appointed Gertjan Bartlema as Chief Executive Officer and Peter Greaney as Chief Business Officer. This new team brings decades of industry experience from leading global pharmaceutical companies including Celgene, Amgen, Hospira, ADC Therapeutics and Alvotech. Their expertise will be crucial in guiding IMM-101 through late-stage clinical development and maximising its potential for patients. Richard Davies, Chairman of the Board, said: “I am excited to join Immodulon’s Board of Directors as Chairman at this pivotal time for the company. Immodulon has generated compelling Phase 2 data with IMM-101, which has the potential to make a real impact on the treatment of pancreatic cancer where patients have limited new treatment options. Gertjan and Peter are highly experienced biotech executives and I look forward to supporting them and the Board in realising IMM-101’s true potential, providing a new therapy for patients suffering from pancreatic cancer and maximising the return for investors.” Gertjan Bartlema, Chief Executive Officer of Immodulon, added: “Having joined the Immodulon Board last year, I am honoured to take on the role of leading the company towards its goal of improving outcomes for patients with pancreatic cancer. I am excited to work with the team to accelerate the clinical development of IMM-101 in combination with Abraxane (nab-paclitaxel) and gemcitabine. I’m inspired by this opportunity of making a meaningful impact with this potential new treatment regimen for patients suffering from pancreatic cancer.” Richard Davies Richard has over 30 years’ pharmaceutical industry experience and is currently Deputy Chairman of the Board of Directors for Alvotech. Richard served as CEO of BONESUPPORT AB, a public Scandinavian orthobiologics company, CEO of Auregen SA, a tissue engineering company and Chief Commercial Officer of Hospira, at the time the world’s largest injectable drug manufacturer, subsequently acquired by Pfizer. Additionally, Richard spent 9 years at Amgen in a range of senior management roles across various geographies after beginning his early career at Eli Lilly. Richard holds a BSc in Applied Chemistry from the University of Portsmouth and an MBA from the University of Warwick. Gertjan Bartlema Gertjan is a global biotech leader with over 25 years’ industry experience in finance, business development and operations. Most recently, Gertjan was CEO of VICO Therapeutics BV, a privately held Netherlands-based company. Prior to VICO, Gertjan spent 12 years at Celgene where he started as part of their initial European management team based in Switzerland. As a member of its New Jersey based corporate business development team, he played a key role in the acquisition of Abraxis BioScience, adding Abraxane to Celgene’s portfolio. Gertjan started his career at Amgen and over a 9-year period held various roles at its European (Switzerland) and corporate headquarters in the US. Gertjan holds an MSc in Economics from Maastricht University, Netherlands. Peter Greaney, PhD Peter is a highly experienced business development executive, with over 20 years’ international industry expertise. Previously, Peter served as Head of Corporate Development at ADC Therapeutics where he played an integral role transforming the company from a private R&D biotech to a NYSE-listed public biotech with a commercial therapeutic product. Prior to ADC Therapeutics, Peter spent 12 years at Celgene in a number of roles of increasing responsibility in Switzerland and the US across medical, commercial and business development and played a key role integrating Abraxane into the Celgene portfolio. Peter began his career as a Preclinical Senior Scientist at Apoxis. Peter holds a BSc in Cell Biology from the University of East Anglia and a PhD in Molecular and Cellular Biology from the University of Nottingham. -Ends - Notes to Editors About Immodulon Therapeutics LtdImmodulon is a late-stage clinical company developing a highly differentiated cancer immunotherapy approach that primes the patient’s own innate immune system with the aim to significantly enhance the efficacy of a broad range of anti-cancer therapies, including chemotherapy and checkpoint inhibitors. Immodulon is developing IMM-101, a heat-killed formulation of the mycobacterium M. obuense, as a broad-spectrum immunomodulatory agent that has promising potential in a range of difficult-to-treat tumours including those considered to be immunologically “cold,” such as pancreatic ductal adenocarcinoma. Immodulon has generated promising, positive Phase 2 data with IMM-101 in pancreatic cancer in combination with gemcitabine. These data show that IMM-101 is safe and effective, prolonging progression-free survival for a sub-group of patients with metastatic disease compared to gemcitabine alone. IMM-101 is due to enter a pivotal pancreatic cancer study. Contacts: ImmodulonGertjan Bartlema, CEOG.Bartlema@immodulon.comPeter Greaney, CBOP.Greaney@immodulon.com MEDiSTRAVA Consulting Frazer Hall, Sandi Greenwood, Eleanor Perkin Immodulon@medistrava.com+44 (0)203 928 6900