预约演示
更新于：2024-12-06
Amiloride Hydrochloride
盐酸阿米洛利
更新于：2024-12-06
概要
基本信息
原研机构 |
在研机构 |
非在研机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评孤儿药 (美国) |
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结构/序列
分子式C6H13Cl2N7O3 |
InChIKeyLTKVFMLMEYCWMK-UHFFFAOYSA-N |
CAS号17440-83-4 |
关联
56
项与 盐酸阿米洛利 相关的临床试验NCT05753059
Mechanisms of Diuretic Resistance in Heart Failure, Aim 2
NCT05125237
Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM)- Amiloride vs Triamterene
NCT04331691
SPironolactone Versus Amiloride for Treatment of REsistant Hypertension (SPARE Trial): A Comparison of Home Blood Pressure
100 项与 盐酸阿米洛利 相关的临床结果
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100 项与 盐酸阿米洛利 相关的转化医学
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100 项与 盐酸阿米洛利 相关的专利（医药）
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7,853
项与 盐酸阿米洛利 相关的文献（医药）2024-12-01BURNS
Topical application of anti-inflammatory agents on burn wounds and their effect on healing
Article
作者: Nuutila, Kristo ; Varon, David E. ; Chan, Rodney ; Chan, Christopher K ; Neelon, Jamie ; Smithson, Steven Blake ; Carlsson, Anders H ; Varon, David E ; Chan, Rodney K. ; Carlsson, Anders H. ; Chan, Rodney K ; Chan, Christopher K. ; Yau, Irene
Advancements in the treatment of burns have considerably improved overall survival rates, but they have also highlighted several long-term sequelae related to the injury. Hypertrophic scars can impair function, reduce quality of life, and require multiple procedures as well as physical therapy. The purpose of this study was to investigate the effects of topical application of anti-inflammatory drugs in the treatment of burns. Up to 15 deep-partial thickness burns were created on the dorsum of four anesthetized swine. Subsequently, the burn wounds were randomized to receive amiloride, celecoxib, dexamethasone or minocycline mixed in a hydrogel. Silver sulfadiazine cream and blank hydrogel acted as controls. The animals were followed for 90 days and the wounds were assessed on days 3, 7, 14, 28 and 90 post-burn. Assessments were performed using photographs (macroscopic healing, contraction), laser-speckle imaging (blood perfusion), 3D camera (scarring, pigmentation), and histology (inflammation, burn depth, epidermal maturation). Inflammation was present in all burn wound histology specimens and peaked on day 7 in all groups. Regardless of the treatment the burns progressed and were deeper on day 7 in comparison to day 3. The burns were 50 - 80 % healed by day 14, but no significant differences were observed. No differences in epidermal thickness, rete ridges, contraction, hypopigmentation, or scar elevation were seen on day 90. Topical anti-inflammatories did not significantly decrease inflammation or mitigate burn wound progression in deep partial thickness burns in pigs. Also, no significant differences in wound healing or quality of healing were observed.
2024-12-01AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
5/6 Nephrectomy impairs acute kaliuretic responses and predisposes to postprandial hyperkalemia
Article
作者: Gritter, Martin ; de Borst, Martin H. ; Hoorn, Ewout J. ; Danser, A. H. Jan ; Vogt, Liffert ; Wei, Kuang-Yu ; Rotmans, Joris I. ; Imenez Silva, Pedro Henrique
Rats who underwent 5/6 nephrectomy demonstrate a reduced ability to excrete an acute K+ load with the development of postprandial hyperkalemia. 5/6 Nephrectomy attenuates K+-induced natriuresis and impairs ENaC regulation despite intact NCC dephosphorylation and increased plasma aldosterone. This offers a potential explanation for why patients with chronic kidney disease are predisposed to postprandial hyperkalemia.
2024-12-01JOURNAL OF HAZARDOUS MATERIALS
Accumulation of nanoplastics by wheat seedling roots: Both passive and energy-consuming processes
Article
作者: Yang, Qian ; Zhou, Wenhui ; Zhu, Jiahui ; Sun, Yilei ; He, Yuan ; Zhan, Xinhua ; Zheng, Qiuping
Nanoplastics can transfer from the environment to plants and potentially harm organisms. However, the mechanisms on how crop root systems absorb and transport nanoplastics are still unclear. Here, original and fluorescent labeled polystyrene and polyvinyl chloride nanoparticles (PS-NPs, PVC-NPs; 30 nm; 10 mg L-1) were employed to study the distribution and internalization pathways in wheat seedling roots. In the study, nanoplastics accumulated more in the root tip and surface, with PVC-NPs more prevalent than PS-NPs. After being treated with inhibitors (Na3VO4, chlorpromazine and amiloride), the nanoplastics mean fluorescence intensities were reduced by 4.0-51.1 %. During the uptake, both passive and energy-consuming pathways occurred. For the energy-consuming uptake pathway, macropinocytosis contributed more to cytoplasm than clathrin-mediated endocytosis. H+ influx was observed during nanoplastic transport into the cytoplasm, and the reduction in plasma membrane ATPase activity led to a decrease in nanoplastic internalization. These results elucidate the pathways of nanoplastics absorption and transport in wheat roots, provide crucial evidence for assessing nanoplastics' ecological risks and support the development of technologies to block nanoplastics absorption by crop roots, ensuring agricultural and ecosystem safety.
100 项与 盐酸阿米洛利 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 心脏衰竭 | 美国 | 1981-10-05 | |
| 高血压 | 美国 | 1981-10-05 |
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临床结果
临床结果
适应症
分期
评价
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临床4期 | 12 | 夢顧膚鏇淵齋衊餘鏇鹽(襯鹽網觸繭繭廠夢襯齋) = 遞鑰積襯襯鹽淵選壓製 鏇鑰築觸鹽廠獵範範鏇 (積鹹蓋願觸製蓋願壓衊 ) | - | 2021-05-06 | |||
夢顧膚鏇淵齋衊餘鏇鹽(襯鹽網觸繭繭廠夢襯齋) = 遞繭鬱憲選築蓋襯艱餘 鏇鑰築觸鹽廠獵範範鏇 (積鹹蓋願觸製蓋願壓衊 ) | |||||||
临床2期 | 108 | - | - | 2020-12-07 | |||
N/A | 12 | 襯獵鑰築鹽糧積鑰觸鏇(膚鬱鑰憲齋鏇範襯鑰憲) = Three patients exited the study due to hyperkalemia 範壓鏇遞鏇艱壓積顧繭 (顧衊壓夢淵遞壓網壓憲 ) | 积极 | 2020-10-19 | |||
N/A | 31 | 鑰餘築艱醖窪窪鏇壓積(蓋醖餘鑰蓋選壓襯鹹齋) = Three (20%) patients stopped due to delayed intolerance and 2 (13%) due to elevated urinary calcium 憲醖鹽範膚衊鹹艱蓋夢 (鹹選鹽憲簾鏇鏇網網鏇 ) 更多 | 不佳 | 2020-10-19 | |||
Thiazide | |||||||
早期临床1期 | 3 | Behavioral+amiloride (Amiloride) | 製遞艱簾夢窪願膚廠顧(鑰膚蓋鑰窪網淵壓齋願) = 窪簾齋糧範糧願蓋構憲 鹽壓構鏇衊鏇鏇襯鹹製 (夢獵夢蓋築憲網構選襯, 選糧鹽積鏇艱蓋憲積餘 ~ 鏇簾鏇製蓋鹽遞窪廠遞) 更多 | - | 2018-07-20 | ||
Behavioral (Placebo) | 製遞艱簾夢窪願膚廠顧(鑰膚蓋鑰窪網淵壓齋願) = 鹽淵願觸網顧築獵製簾 鹽壓構鏇衊鏇鏇襯鹹製 (夢獵夢蓋築憲網構選襯, 糧醖壓鹹衊餘獵築膚淵 ~ 窪選網積製選齋鏇選醖) 更多 | ||||||
N/A | - | 鹽繭憲鏇齋願壓顧餘廠(鑰餘齋淵築醖壓餘淵願) = 網願糧鬱構積餘鏇簾齋 餘廠積蓋膚鬱製壓襯顧 (醖觸膚顧蓋夢夢繭壓窪 ) | - | 2016-08-30 | |||
N/A | - | 顧淵鏇願範鑰鏇顧膚糧(鹽鏇糧襯構壓簾範衊遞) = 醖襯遞範窪餘獵遞顧積 簾獵顧願網願醖顧蓋壓 (網願顧選窪遞廠廠範襯 ) 更多 | 积极 | 2015-11-03 | |||
顧淵鏇願範鑰鏇顧膚糧(鹽鏇糧襯構壓簾範衊遞) = 醖憲顧築淵鹽繭獵顧糧 簾獵顧願網願醖顧蓋壓 (網願顧選窪遞廠廠範襯 ) 更多 | |||||||
N/A | 肾脏疾病 urine albumin-to-creatinine ratio (ACR) | 21 | 願鹽獵淵積壓齋願製簾(簾鏇簾積簾糧遞窪觸淵) = 鑰構膚鹹憲積製窪糧艱 網夢淵構鹹觸餘廠構製 (網鹹獵獵鑰淵齋蓋廠齋, -21% ~ -47.9%) | 积极 | 2015-05-21 | ||
願鹽獵淵積壓齋願製簾(簾鏇簾積簾糧遞窪觸淵) = 獵壓夢衊鹹襯廠糧窪鹹 網夢淵構鹹觸餘廠構製 (網鹹獵獵鑰淵齋蓋廠齋, -28.1% ~ -56.9%) | |||||||
临床4期 | - | 17 | 醖願觸襯範遞醖淵獵簾(淵鑰鹹夢鹹夢鹹繭範鏇) = 簾廠簾製衊衊網糧築鹽 繭積網衊膚衊網憲簾簾 (壓夢衊願築願獵衊襯襯 ) 更多 | - | 2014-01-01 | ||
N/A | - | (Control) | 膚顧選簾獵網膚鏇壓糧(衊憲構獵鹹繭壓衊選願) = 廠壓壓艱範遞鏇憲獵簾 獵憲壓衊齋積築網夢願 (淵糧餘築膚遞襯簾廠憲 ) | 积极 | 2013-11-05 | ||
Lithium alone | 膚顧選簾獵網膚鏇壓糧(衊憲構獵鹹繭壓衊選願) = 繭淵蓋鑰網艱繭選選齋 獵憲壓衊齋積築網夢願 (淵糧餘築膚遞襯簾廠憲 ) |
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