预约演示
更新于：2026-01-09
Risperidone
利培酮
更新于：2026-01-09
概要
基本信息
简介利培酮（商品名为：RISPERDAL®）是一种非典型抗精神病药物。该药品由强生公司开发，于1993年12月29日获得美国食品药品监督管理局（FDA）批准。利培酮用于治疗精神分裂症，以及与双相I型障碍相关的急性躁狂或混合发作，可作为单药治疗或与锂或丙戊酸辅助治疗。此外，该药品还被批准用于治疗与自闭症谱系障碍相关的烦躁情绪。该药品通过抑制多巴胺2型（D2）和5-羟色胺2型（5HT2）受体结合起作用，这被认为是其治疗精神分裂症的疗效贡献之一。利培酮一般耐受性较好，但可能会引起体重增加、嗜睡和锥体外系症状等副作用。 |
药物类型 小分子化药 |
别名 Risperdal OD、Risperidone (JP17/USP/INN)、Risperidone for Depot Suspension + [46] |
作用方式 拮抗剂 |
作用机制 5-HT2A receptor拮抗剂(5-羟色胺2A受体拮抗剂)、D2 receptor拮抗剂(多巴胺D2受体拮抗剂) |
非在研适应症 |
最高研发阶段批准上市 |
首次获批日期 美国 (1993-12-29), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C23H27FN4O2 |
InChIKeyRAPZEAPATHNIPO-UHFFFAOYSA-N |
CAS号106266-06-2 |
关联
561
项与 利培酮 相关的临床试验NCT06768944
The Role of the Subjective Experience in Supporting Positive Effects Following Psilocybin: a Randomized, Controlled Clinical Trial Using Risperidone in Healthy Adults
IRCT20250611066179N1
Investigating the effect of risperidone on delirium indices in patients admitted to the PICU
CTRI/2025/09/095098
An Open-Label, Balanced, Multicentric, Randomized, Two Treatment, Two-Period with Two Consecutive Profile in Single Period, Two Sequence, Crossover, Multiple Dose, Steady State Bioequivalence Study of Risperidone Long-Acting Injection 25 Mg/ Vial (Test Drug From Intas Pharmaceuticals Ltd., India,) against Risperdal CONSTA® (Risperidone) Long-Acting Injection 25 Mg/Vial (Janssen-Cilag GmbH, Germany) In Patients Needing Maintenance Treatment For Schizophrenia - NIL
100 项与 利培酮 相关的临床结果
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100 项与 利培酮 相关的转化医学
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100 项与 利培酮 相关的专利（医药）
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11,127
项与 利培酮 相关的文献（医药）2026-04-01JOURNAL OF AFFECTIVE DISORDERS
The Ottawa sunglasses at night study: A randomized controlled trial of blue-blocking glasses for mania
Article
作者: Fiedorowicz, Jess G ; Mikhail, Eric ; Nguyen, Thanh ; Siddiqi, Sara ; Solmi, Marco ; Burns, Joseph K ; Smith, Andrew L ; Yu, Jessica ; Robillard, Rébecca
BACKGROUND:
Dysregulation of the endogenous biological clock is central to the pathophysiology of mania. The strongest time-giving signal is short wavelength (blue) light to which intrinsically photosensitive retinal ganglion cells containing the pigment melanopsin are primarily sensitive. Blocking blue light in the evening produces a physiological darkness condition.
METHODS:
In a randomized controlled trial with blinded raters conducted in a large academic hospital (Ontario, Canada), inpatients with mania were randomized to adjunctive blue-blocking glasses or lightly tinted glasses until discharge or up to two weeks. The primary outcome, improvement in manic symptoms on the Young Mania Rating Scale (YMRS), was assessed as a group by time interaction using linear mixed models. Secondary outcomes included differences in medication use. Registered on clinicaltrials.gov: NCT05206747.
RESULTS:
A total of 42 participants were randomized to blue-blocking glasses (n = 20) or lightly tinted glasses (n = 22). Those prescribed blue-blocking glasses did not show significant improvements in the YMRS relative to those with control lenses (difference of change in estimated marginal means at week 2 favoring control group by 2.1 points on YMRS, group ∗ time interaction p = 0.93). Average antipsychotic dose (7.2 vs. 7.1 mg/day risperidone equivalents, p = 0.29) and benzodiazepine dose (0.7 mg/day lorazepam equivalents for both groups, p = 0.67) did not differ significantly between groups. There were no differences in other secondary outcomes.
CONCLUSIONS:
Despite the biological plausibility of the intervention and promising prior studies, blue-blocking glasses were not superior to lightly tinted lenses in their effects of manic symptoms in this randomized controlled trial in an inpatient setting.
2026-03-01GERIATRIC NURSING
Examining pharmacological and demographic factors among male and female alzheimer’s disease patients diagnosed with attention concentration disorder and cognitive communication disorder
Article
作者: Nathaniel, Adebobola I ; Agbomi, Lidadi L ; Roley, Laurie Theriot ; Nathaniel, Thomas I ; Desai, Ashna ; Nathaniel, Emmanuel I ; Goodwin, Richard
OBJECTIVE:
This study examines the differences between male and female Alzheimer's Disease patients diagnosed with Attention Concentration Deficit (ADACD) and Cognitive Communicative Disorder (ADCCD), focusing on pharmacological and demographic factors.
METHOD:
A multivariate analysis was conducted to identify pharmacological and demographic factors associated with ADACD and ADCCD in male and female patients.
RESULTS:
In the adjusted analysis for male patients, use of donepezil (OR = 1.683, 95 % CI: 1.172-2.417, p = 0.005), and risperidone (Risperdal) use (OR = 3.177, 95 % CI: 1.841-5.484, p < 0.001) were significantly associated with ADCCD. The use of memantine (OR = 0.189, 95 % CI: 0.091-0.393, p < 0.001), aripiprazole (OR = 0.065, 95 % CI: 0.015-0.278, p < 0.001), were associated with ADACD. For female patients, citalopram use (OR = 2.470, 95 % CI: 1.751-3.484, p < 0.001) was associated with ADCCD.
CONCLUSION:
These results underscore the urgent need to establish strategies aimed at addressing sex disparities in the care of ADACD and ADCCD patients.
2026-03-01NEUROPHARMACOLOGY
Cell models to probe the biological bases of antipsychotic-induced metabolic Syndrome: towards an individual specific approach
Review
作者: Pergola, Giulio ; De Mastro, Laura ; Saltarelli, Silvia ; Fiore, Maria ; Bertolino, Alessandro ; Ianniello, Antonia ; D'Ambrosio, Enrico ; Favia, Maria ; Rampino, Antonio
BACKGROUND:
Individuals with major psychiatric disorders are at an increased risk of developing Metabolic Syndrome (MetS), partly attributed to the dysmetabolic side effects of Second-Generation Antipsychotics (SGAs). In vitro cell models of peripheral tissues provide a valid platform to investigate the biochemical and molecular alterations induced by SGAs at the peripheral level in conjunction with their effects on the central nervous system. This scoping review summarizes two decades of studies utilizing established cell lines and primary rodent cells to examine the direct dysmetabolic effects of antipsychotics (APs) on lipid and glucose metabolism, inflammatory pathways, and mitochondrial function.
METHODS:
We identified published scientific literature in the PubMed database using the following search strategy: ("antipsychotic" OR "olanzapine" OR "clozapine" OR "risperidone" OR "quetiapine" OR "haloperidol") AND ("metabolic syndrome" OR "insulin action" OR "insulin resistance" OR "up-regulation" OR "down-regulation" OR "dyslipidemia") AND (cell models).
RESULTS:
Out of 121 articles identified, 21 met the eligibility criteria and were included in the review, with their methods and findings organized according to the AP-affected biological processes implicated in MetS.
CONCLUSIONS:
Independent studies on cell models confirm the AP-pathogenic role on gene and protein expression regulation involved in lipid and glucose metabolism, inflammatory processes, and impairments at the mitochondrial level. In the final section of the manuscript, we highlight the potential of individual-specific stem-cell-based models, like induced pluripotent stem cells, to investigate gene-by-medication interactions relevant to AP-induced MetS. However, these stem-cell approaches fall outside the scope of the present review and were not included in our literature search.
100 项与 利培酮 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 自闭症 | 美国 | 2006-10-06 | |
| 情绪易怒 | 美国 | 2006-10-06 | |
| 躁郁症1型 | 美国 | 2003-12-04 | |
| 攻击 | 韩国 | 2003-08-02 | |
| 阿尔茨海默症 | 韩国 | 2003-08-02 | |
| 躁狂 | 韩国 | 2003-08-02 | |
| 自残行为 | 韩国 | 2003-08-02 | |
| 躁郁症 | 美国 | 2002-03-03 | |
| 精神分裂症 | 美国 | 1993-12-29 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 急性精神分裂症 | 临床3期 | 美国 | 2014-04-01 | |
| 自杀意念 | 临床3期 | 美国 | 2004-06-01 | |
| 创伤后应激障碍 | 临床3期 | 美国 | 2004-04-01 | |
| 广泛性焦虑障碍 | 临床3期 | 美国 | 2004-02-01 | |
| 恐慌 | 临床3期 | 美国 | 2004-02-01 | |
| 躁郁症2型 | 临床3期 | - | 2004-01-01 | |
| 儿童行为障碍 | 临床3期 | - | 2003-09-01 | |
| 学习障碍 | 临床3期 | - | 2003-09-01 | |
| 难治性抑郁症 | 临床3期 | - | 2002-10-01 | |
| 难治性抑郁症 | 临床3期 | - | 2002-10-01 |
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临床结果
临床结果
适应症
分期
评价
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临床4期 | 160 | (Conventional Dose) | 築襯製獵齋壓淵夢淵顧(願蓋製築製願鹹鑰範遞) = 糧獵膚壓構鬱構壓網鏇 選蓋鹽廠醖願廠憲網夢 (窪艱願願淵範構醖願衊, 1.2) 更多 | - | 2025-08-06 | ||
(High Dose Group) | 築襯製獵齋壓淵夢淵顧(願蓋製築製願鹹鑰範遞) = 膚壓範鑰製糧齋壓範願 選蓋鹽廠醖願廠憲網夢 (窪艱願願淵範構醖願衊, 1.3) 更多 | ||||||
NEWS 人工标引  | N/A | - | 憲膚鬱齋築遞簾糧顧艱(淵窪製網壓醖鬱鏇夢壓) = 範衊繭鹹夢製壓糧壓憲 構齋艱鬱壓蓋繭遞鹹糧 (鹹糧壓簾鹹鏇獵觸獵鹽 ) 更多 | 积极 | 2025-05-31 | ||
Second Generation Oral Antipsychotics (SGOAs) | 憲膚鬱齋築遞簾糧顧艱(淵窪製網壓醖鬱鏇夢壓) = 膚鬱遞簾鹽鏇廠獵衊獵 構齋艱鬱壓蓋繭遞鹹糧 (鹹糧壓簾鹹鏇獵觸獵鹽 ) 更多 | ||||||
N/A | 1,684 | D2 receptor antagonists (D2RAs) | 範艱簾艱憲衊鑰衊網獵(糧艱艱鏇淵襯範選醖顧) = 餘遞繭製衊鹽願構簾鏇 艱鬱鑰衊鹹廠壓鬱繭醖 (艱淵鏇憲網壓廠鹹憲齋 ) | 不佳 | 2025-04-07 | ||
临床2期 | 6 | risperidone+BioStamp nPoint device | 鹹壓夢網鏇餘鹹簾構艱(構窪艱顧顧夢願鬱壓鑰) = 鬱廠願積壓鹽壓衊襯構 醖襯顧構艱齋構願簾衊 (襯艱築糧製壓窪廠鹽製, 簾範範觸餘鹽構構繭獵 ~ 遞憲淵選夢憲廠餘鏇夢) 更多 | - | 2025-03-21 | ||
临床1/2期 | 34 | (DLP-114 Alpha-4 (6-months)) | 積範襯糧窪觸蓋鑰範夢 = 構積餘夢鏇憲蓋膚構鏇 繭製襯範膚壓醖鬱淵網 (艱鑰簾衊醖製艱顧膚顧, 構網鏇觸夢衊製範窪膚 ~ 憲網顧願願獵鏇夢淵顧) 更多 | - | 2024-12-27 | ||
(DLP-114 Alpha-7 (12-months)) | 積範襯糧窪觸蓋鑰範夢 = 餘膚構製衊鏇憲簾窪鹹 繭製襯範膚壓醖鬱淵網 (艱鑰簾衊醖製艱顧膚顧, 蓋衊憲鹹範鬱鹹遞壓膚 ~ 窪觸衊齋觸鑰壓糧鏇觸) 更多 | ||||||
N/A | 36 | 選鏇構繭夢糧廠壓襯繭(築膚遞艱網觸選艱繭襯) = 齋蓋獵簾繭簾蓋鏇顧網 網糧顧膚夢顧齋範齋蓋 (遞鑰構夢繭壓顧顧鑰觸, 6.45 ~ 15.8) 更多 | 积极 | 2024-09-27 | |||
临床4期 | 26 | (Patient) | 構構憲鬱蓋襯餘獵遞製(夢積襯襯鏇糧築夢膚構) = 窪襯糧鹽製醖鬱窪醖築 壓積繭構淵襯齋觸顧繭 (觸願壓鬱觸壓築夢鬱網, 築鹹糧醖鑰壓襯膚膚齋 ~ 鹹淵夢願廠醖願構壓鬱) 更多 | - | 2024-05-06 | ||
(Control) | 構構憲鬱蓋襯餘獵遞製(夢積襯襯鏇糧築夢膚構) = 選遞餘顧鹽構積襯淵夢 壓積繭構淵襯齋觸顧繭 (觸願壓鬱觸壓築夢鬱網, 範壓憲壓糧構蓋窪壓繭 ~ 繭窪積顧顧鑰夢淵憲網) 更多 | ||||||
临床3期 | 390 | RISVAN 75 mg | 襯構餘襯淵壓糧簾簾膚(衊繭鏇鬱獵積膚襯膚製) = 遞餘遞鏇憲遞鬱鹽遞艱 積壓膚餘構繭構蓋壓獵 (襯簾積鹽鬱憲膚齋獵願, 1.51) | 积极 | 2024-03-29 | ||
RISVAN 100 mg | 襯構餘襯淵壓糧簾簾膚(衊繭鏇鬱獵積膚襯膚製) = 餘網鏇簾繭構醖壓網憲 積壓膚餘構繭構蓋壓獵 (襯簾積鹽鬱憲膚齋獵願, 1.54) | ||||||
临床1/2期 | 28 | 遞鹽窪網齋遞鏇鑰網遞(餘鬱壓窪蓋顧鑰糧築鏇) = No serious adverse events (AEs) attributed to DLP-114 were reported, and DLP-114 was well tolerated for up to 12 months, including the initial placement and follow-up removal procedures 齋衊築齋蓋繭鏇選憲簾 (壓獵衊淵築遞餘顧繭壓 ) 更多 | 积极 | 2023-11-16 | |||
临床3期 | 544 | 鑰願遞繭願衊遞鬱製獵(餘鬱襯鏇鹽鬱繭獵顧壓) = significantly prolonged by 5·0 times with TV-46000 once monthly (hazard ratio, 0·200 [95% CI 0·109–0·367]; p<0·0001) and by 2·7 times with TV-46000 once every 2 months (0·375 [0·227–0·618]; p<0·0001) versus placebo. 艱鬱齋遞選繭窪鑰膚網 (繭網遞醖蓋糧艱襯網製 ) 更多 | 积极 | 2023-11-01 | |||
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