A Randomized,Controlled Phase III Study on Efficacy and Safety of Utidelone Capsule and Utidelone Injection in Patients With HER-2 Negative Advanced Breast Cancer

This study is a randomized controlled study.The primary objective is to evaluate the Progression-Free Survival(PFS) of Utidelone Capsule combined with Capecitabine compared with Utidelone Injection combined with Capecitabine in patients with HER-2 negative advanced breast cancer.

开始日期2026-08-01

申办/合作机构

北京华昊中天生物医药股份有限公司

ChiCTR2600124228

/ Not yet recruiting临床2期IIT

Efficacy and Safety of Utidelone Combined with Anlotinib as Second-Line Therapy for Advanced Non-Specific Soft Tissue Sarcoma: A Multicenter, Single-Arm, Phase II Clinical Study

开始日期2026-05-07

申办/合作机构-

NCT07449481

/ Withdrawn临床2期IIT

A Single-Arm, Open-Label, Phase II Clinical Study of Utidelone and Bevacizumab With or Without Etoposide in Patients With Brain Metastases From Malignant Solid Tumors

Brain metastasis represents one of the worst prognostic outcomes in advanced malignant tumors. Approximately 10% to 40% of patients with solid tumors develop brain metastases, a incidence rate significantly higher than that of primary malignant brain tumors. Over 80% of patients present with multiple brain metastases at diagnosis, often precluding surgical intervention.
Brain metastases typically occur in the late stages of cancer. Patients have often received multiple prior therapies and developed resistance to first- and second-line drugs, leaving limited pharmacological options. The rapid growth of intracranial tumors poses an immediate threat to life. Consequently, radiotherapy and surgery currently form the cornerstone of clinical management for these patients. Thus, developing effective systemic therapies is an urgent and unmet medical need .
Utidelone, a new-generation epothilone anticancer agent, has demonstrated good efficacy and safety. Previous studies indicate that utidelone achieves higher concentrations in most tissues, including the brain, compared to plasma, suggesting its ability to readily cross the blood-brain barrier . Furthermore, a Phase III clinical trial in metastatic breast cancer showed that utidelone in combination with capecitabine significantly improved the objective response rate (ORR), progression-free survival (PFS), and overall survival (OS) compared to capecitabine alone in patients previously treated with anthracyclines and taxanes .
A separate Phase II study demonstrated that bevacizumab combined with carboplatin achieved a central nervous system objective response rate (CNS ORR) of 63%, with a median PFS of 5.62 months and a median OS of 14.1 months in breast cancer patients with brain metastases . Regarding safety, utidelone has a relatively low incidence of adverse reactions aside from peripheral neurotoxicity .
Based on this evidence, this proposed study aims to evaluate the efficacy and safety of utidelone and bevacizumab, combined with etoposide for breast cancer cohorts or without etoposide for lung cancer cohorts, in patients with malignant tumor brain metastases.

开始日期2026-05-01

申办/合作机构

天津市肿瘤医院（天津医科大学肿瘤医院）

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100 项与优替德隆相关的临床结果

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100 项与优替德隆相关的转化医学

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100 项与优替德隆相关的专利（医药）

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272

项与优替德隆相关的文献（医药）

2026-05-01·Translational Cancer Research

Utidelone exhibits favorable responses in refractory patients with advanced breast cancer

Article

作者: Lan, Xiaofeng ; Bai, Xue ; Huang, Jiayi ; Liu, Meidi ; Song, Lin ; Xie, Xiaofeng ; Lei, Rongmei ; Zhang, Qiuyi ; Chen, Liping ; Du, Caiwen ; Chen, Xuelian

Background:

Utidelone plus capecitabine has brought therapeutic and survival benefits in the second-line treatment of patients with advanced breast cancer (ABC). However, its efficacy in the subsequent treatment remains to be disclosed. Our study aimed to investigate the efficacy and safety of utidelone in the treatment of refractory ABC in real-world.

Methods:

In this single-center, retrospective cohort study, clinical data were retrospectively collected from patients who received utidelone at Cancer Hospital, Chinese Academy of Medical Sciences, Shenzhen after developing resistance to anthracyclines or taxanes. The median progression-free survival (PFS) was estimated using the Kaplan-Meier method, and statistical analysis was performed using SPSS 18.0 software (IBM SPSS, Armonk, NY, USA).

Results:

A total of 20 patients were included in the study, 95% of whom had previously received third-line therapy or more at the time of utidelone treatment. The overall objective response rate (ORR) and disease control rate (DCR) were 15% and 80%, respectively, with a median PFS of 4.7 months [95% confidence interval (CI): 2.98-6.42]. Patients with hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR⁺/HER2^-) exhibited better efficacy, with an ORR of 30% and a DCR of 90%. Among the five patients who developed brain metastases (BMs) and received combined anti-angiogenic therapy, the intracranial ORR (iORR) and intracranial DCR (iDCR) were 20% and 100%, respectively. In general, utidelone was well tolerated, with neurotoxicity being the main adverse event.

Conclusions:

Utidelone demonstrates favorable efficacy and safety in patients with refractory ABC, particularly in HR⁺/HER2^- patients. The combination of utidelone with anti-angiogenic therapy shows promising intracranial anti-tumor activity and is expected to be a preferred option for ABC in subsequent lines of treatment.

2026-01-01·Frontiers in Oncology

Atrial fibrillation during palliative chemotherapy with utidelone: a case report.

Article

作者: Chen, Baoying ; Shen, Qihuan ; Shi, Huadi ; Xu, Zumin ; Huang, Yuhao ; Li, Haoran

This report describes a 57-year-old male patient with metastatic breast cancer who experienced atrial fibrillation during the infusion of utidelone as palliative chemotherapy. All cardiological examinations conducted before treatment were normal. There was no evidence of thyroid dysfunction, nor any objective data indicating acute or chronic cardiovascular disease. Other combination drugs have been used in clinical practice for decades and rarely have proarrhythmic activity. The innovative drug utidelone, independently developed in China, was approved by the National Medical Products Administration (NMPA) of China in 2021 for the treatment of patients with metastatic breast cancer. Cardiotoxicity has not been prominently reported in prior clinical trials of utidelone. Although a definite causal relationship cannot be confirmed, the close temporal association and clinical course suggest that utidelone may have contributed to the arrhythmias. This case highlights the need for careful cardiac monitoring during treatment.

2026-01-01·Advances in Protein Chemistry and Structural Biology

Pathological microtubule dynamics in Parkinson’s disease: Mechanisms and therapeutic implications

Review

作者: Prajapati, Vijay Kumar ; Baghel, Kirti ; Singh, Satyendra ; Dubey, Ateendra Kumar

Parkinson's disease (PD) is a progressive neurodegenerative disorder primarily marked by the degeneration of dopaminergic neurons in the substantia nigra and the pathological accumulation of misfolded α-synuclein in Lewy bodies. This chapter explores the underrecognized role of microtubule (MT) dysregulation in PD pathogenesis, linking disruptions in cytoskeletal integrity to impaired axonal transport and neuronal survival. The fundamental biology of MTs, their dynamics, and their regulation by motor proteins and associated proteins like MT-associated proteins (MAPs), tau, and gamma-tubulin complexes. Special attention is given to how mutations linked to PD, such as those in SNCA (α-synuclein), Parkin, PINK1 (PTEN-induced kinase 1), and LRRK2 (leucine-rich repeat kinase 2), lead to MT destabilization, impaired mitophagy, and disruptions in axonal transport. A self-perpetuating cycle of MT disruption and α-synuclein aggregation is proposed, resulting in synaptic failure and dopaminergic neuron loss. The chapter also evaluates emerging therapeutic strategies targeting MT stabilization, including LRRK2 inhibitors, MT-stabilizing agents like Epothilone D, and approaches to modulate α-synuclein aggregation. Challenges such as the blood-brain barrier, off-target effects of MT-targeting drugs, and patient-specific variability in drug response are critically discussed. The future directions include CRISPR-Cas9-based gene therapies and personalized medicine, emphasizing the need for a deeper understanding of PD-related molecular pathways. This comprehensive overview highlights MT dynamics not just as collateral damage but as a central element in PD pathology, offering novel insights into potential avenues for intervention.

305

项与优替德隆相关的新闻（医药）

2026-07-23

·北京医学感染与传染研究

生物医学中心 - 医学 24卷 1期（上半年）

BMC Medicine [Jour] AND 24[volume] AND 1[issue]（first half of the year）生物医学中心 - 医学 24卷 1期（上半年） https://link.springer.com/journal/12916/volumes-and-issues/24-1 369 articles in this issue Impact of a real-time automatic quality control system for magnetically controlled capsule gastroscopy: a multicenter randomized controlled trial 磁控胶囊胃镜实时自动质量控制系统的效果：一项多中心随机对照试验 Xiaoya WangDawei ShenZhen Li Research 02 May 2026 Article: 369 Lipid levels and risk-stratified management gaps of dyslipidemia in China 中国血脂水平及血脂异常风险分层管理差距 Long ZhangXu LiuJianping Li Research 02 May 2026 Article: 368 Medicine price and affordability in China and selected ASEAN countries: a cross-country comparison with forward-looking implications for regional pooled procurement 中国与部分东盟国家的药品价格和可负担性：对区域集中采购前瞻性影响的跨国比较 Zhuangqi LiShuting ZhangBao Liu Research 02 May 2026 Article: 367 Dementia risk by metabolic health and obesity in two prospective cohorts 两项前瞻性队列研究中代谢健康和肥胖对痴呆风险的影响 Martin NakashElsa Ojalehto LindforsIda K. Karlsson Research 19 June 2026 Article: 366 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用 Maternal B-vitamin status modifies the risk of congenital heart disease in offspring associated with prenatal persistent organic pollutants exposure 母体B族维生素状况会改变胎儿在宫内持续暴露于有机污染物时先天性心脏病的患病风险 Sainan LiHai LinLinlin Wang Research 04 May 2026 Article: 365 Obesity-derived metabolites modulate anti-tumor immunity in the tumor microenvironment: from mechanisms to clinical applications 肥胖衍生的代谢产物在肿瘤微环境中调节抗肿瘤免疫：从机制到临床应用 Yihang CaiJunyi JinXiaoying Li Review 06 May 2026 Article: 364 Part of 1 collection:Tumor microenvironment in cancer therapy 所属专题合集：癌症治疗中的肿瘤微环境 Rational use of expensive medicines in the Netherlands: strategies to improve effectiveness and reduce burden on patients and society – a narrative review 荷兰高价药品的合理使用：提高疗效、减轻患者和社会负担的策略——一项叙述性综述 Bart M.F. PenninxSander W. TasCarla E.M. Hollak Review 30 April 2026 Article: 363 NMR-based serum metabolite and lipoprotein profiling for endometriosis across clinically relevant and physiological comparator settings: assessment of diagnostic utility and exploratory biological signals 基于核磁共振（NMR）的血清代谢物和脂蛋白谱分析在子宫内膜异位症的临床相关和生理对照情况中的应用：诊断效用的评估和探索性生物信号的发现 Sisi DengAndré KochChristoph Trautwein Research 17 June 2026 Article: 362 Changes in olfactory function in children and adolescents with obesity following an inpatient weight loss program: a longitudinal study 住院减肥计划后肥胖儿童和青少年嗅觉功能的变化：一项纵向研究 Bea KlosHelene SauerIsabelle Mack Research 17 June 2026 Article: 361 Part of 1 collection:Weight loss interventions and their health impacts 所属专题合集：减肥干预及其对健康的影响 The neuroimmune axis in breast cancer: from mechanistic insights to clinical applications 乳腺癌中的神经免疫轴：从机制研究到临床应用 Yimao WuKaiyu ZhangMeng-Yao Li Review 30 April 2026 Article: 360 A biologically informed framework for instrument selection in dietary Mendelian randomization using chemosensory genetics 基于化学感觉遗传学的饮食孟德尔随机化工具选择生物学框架 Liang-Dar HwangCailu LinPaule V. Joseph Research 01 June 2026 Article: 359 Efficacy and safety of cyclosporine plus luspatercept versus cyclosporine in newly diagnosed non-transfusion-dependent non-severe aplastic anemia: A prospective randomized trial 环孢素联合卢帕塞普特与单用环孢素治疗新发非输血依赖型非重型再生障碍性贫血的疗效和安全性：一项前瞻性随机试验 Zhuxin ZhangQinglin HuBing Han Research 29 April 2026 Article: 358 Dietary intake and epigenetic aging in an African population: food groups, dietary patterns, and plant-based diets in the RODAM study 非洲人群的膳食摄入与表观遗传衰老：RODAM研究中的食物组、膳食模式与植物性饮食 Naomi C.S. AuwerdaMuhau. M. MungambaFelix P. Chilunga Research 28 April 2026 Article: 357 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学与风险因素的作用 Mitoxantrone hydrochloride liposome (Lipo-MIT) combined with capecitabine in HER2-negative advanced breast cancer: a dose-escalation, phase I study 米托蒽醌盐酸盐脂质体（Lipo-MIT）联合卡培他滨治疗HER2阴性晚期乳腺癌：一项剂量递增Ⅰ期研究 Jiaxuan LiuMingxia JiangQiao Li Research 28 April 2026 Article: 356 Familial healthy aging and longevity: the role of spouses 家族健康衰老与长寿：配偶的作用 Søren NetraAngéline GalvinKaare Christensen Research 28 April 2026 Article: 355 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学与风险因素的作用 Peripheral blood biomarkers RCAN1, Clusterin, RAGE, and malondialdehyde for early diagnosis and progression of Alzheimer’s disease 外周血生物标志物RCAN1、Clusterin、RAGE和丙二醛用于阿尔茨海默病的早期诊断与进展监测 Aurora Román-DomínguezCristina Mas-BarguesJosé Viña Research 27 April 2026 Article: 354 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学与风险因素的作用 Palliative care for the people without medical insurance in Germany: an empirical ethical approach 德国无医疗保险人群的姑息治疗：一种实证伦理方法 Matthias ZimmerAntonia Sahm Research 11 June 2026 Article: 353 Part of 1 collection:Palliative care and medicine 所属专题合集：姑息治疗与姑息医学 Maternal factors associate with microbiota-derived extracellular vesicle profiles in pregnancy: a clinical cohort study 妊娠期母体因素与微生物衍生的细胞外囊泡特征的相关性：一项临床队列研究 Jenni TurunenKaisu KyröTerhi Ruuska-Loewald Research 28 May 2026 Article: 352 Prenatal computed tomography (CT) and risk of congenital heart disease and cerebral palsy: A nationwide mother–child paired cohort study 产前计算机断层扫描（CT）与先天性心脏病及脑瘫风险：一项全国性母子配对队列研究 Tae Wook KangJihye HeoDanbee Kang Research 27 April 2026 Article: 351 Therapeutic TG2 inhibition reverses systemic multiomic dysregulation in celiac disease 治疗性TG2抑制可逆转乳糜泻的系统性多组学失调 Valeriia DotsenkoHana Hien Leon behalf of the CEC-3 Investigators Research 24 April 2026 Article: 350 Adulthood stressful life events as predictors of incident cardiovascular disease: insights from two prospective cohorts 成年期应激性生活事件作为心血管疾病新发预测因子：来自两项前瞻性队列的见解 Shuang WuSiqi LyuGregory Y. H. Lip Research 24 April 2026 Article: 349 Camrelizumab plus apatinib for immune checkpoint inhibitor-naive patients with metastatic clear cell renal cell carcinoma after first-line tyrosine kinase inhibitor treatment failure: a single-arm phase 2 trial 卡瑞利珠单抗联合阿帕替尼用于免疫检查点抑制剂初治转移性透明细胞肾细胞癌一线酪氨酸激酶抑制剂治疗失败后：一项单臂Ⅱ期试验 Xiuyu CaiXia ZhengPei Dong Research 24 April 2026 Article: 348 Introducing the need for a consensus-based framework for protocol modifications to improve trial trustworthiness 提出建立基于共识的方案修改框架以提升临床试验可信度的必要性 Cora BurgwinkelManon GicquelClara Locher Debate 24 April 2026 Article: 347 Modelling the epidemic dynamics of HPV among women in China and optimization of ongoing cervical cancer elimination strategies 中国女性人群HPV流行动力学建模及宫颈癌消除策略优化 Yuwei LiYi-Fan LinJianxin Zhen Research 22 April 2026 Article: 346 Multiparameter concept-based interpretable model for early breast cancer diagnosis and structured reporting: a multi-center, multi-reader, radiologist-in-the-loop study 基于多参数概念的可解释模型用于早期乳腺癌诊断与结构化报告：一项多中心、多读者、放射科医师参与的研究 Jiao QuYang LiuSu Lui Research 23 April 2026 Article: 345 Blood-based DNA methylation marker model for short-term and long-term lung cancer risk prediction 基于血液DNA甲基化标志物模型的肺癌短期与长期风险预测 Megha BhardwajYi-Qian SunHermann Brenner Research 06 June 2026 Article: 344 Integrated serum proteomic and liver genomic analyses identify molecular signatures associated with metabolic dysfunction-associated steatotic liver disease: a multi-cohort study 整合血清蛋白质组学与肝脏基因组学分析鉴定与代谢功能障碍相关脂肪性肝病相关的分子特征：一项多队列研究 Jinjian XuWanglong GouYu-ming Chen Research 17 April 2026 Article: 343 Predicting amyotrophic lateral sclerosis stage based on multi-parameter ultrasound: development and validation of an interpretable machine learning model 基于多参数超声预测肌萎缩侧索硬化症分期：可解释机器学习模型的构建与验证 Tianhua YangYing WangGaoyi Yang Research 22 April 2026 Article: 342 Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates 所属专题合集：肌萎缩侧索硬化症：最新进展与更新 Duration of anti-seizure medicines started for acute symptomatic seizures due to acute meningitis: a systematic review and meta-analysis 急性脑膜炎所致急性症状性发作的抗癫痫药物起始疗程：一项系统综述与荟萃分析 Manya PrasadAmit KumarTarun Dua Research 22 April 2026 Article: 341 Part of 1 collection:Acute meningitis: a collection of systematic reviews 所属专题合集：急性脑膜炎：系统综述集 Prenatal exposure to flood and risk of low birth weight: a multi-country study from 36 African countries 产前遭遇洪水与低出生体重风险：来自36个非洲国家的多国研究 Qian LiQian LiFengchao Liang Research 21 April 2026 Article: 340 Part of 1 collection:Climate change and human health 所属专题合集：气候变化与人类健康 Sunshine duration and episodes of mental disorders and the inverse effect modification by ambient temperature 日照时长与精神障碍发作及环境温度的逆效应修饰 Lijun BaiJuan ChenShaowei Wu Research 21 April 2026 Article: 339 The role of continuous glucose monitoring for diagnosis of gestational diabetes: exploring the potential 持续葡萄糖监测在妊娠糖尿病诊断中的作用：潜力探索 M. CrowleyC. NewmanF. P. Dunne Review 21 April 2026 Article: 338 Part of 1 collection:Diagnosis and management of gestational diabetes 所属专题合集：妊娠糖尿病的诊断与治疗 Pre-diagnostic biomarkers and risk of stress-related disorders: a cohort study based on electronic health records 应激相关障碍诊断前生物标志物与风险：一项基于电子健康记录的队列 Anna A. PeltolaEsha KhanJake Lin Research 01 June 2026 Article: 337 Epigenome-wide analysis of DNA-methylation signatures following climate-related disasters 气候相关灾害后DNA甲基化信号的全表观基因组分析 Wenzhong HuangRongbin XuYuming Guo Research 20 April 2026 Article: 336 Part of 1 collection:Climate change and human health 所属专题合集：其后变化与人类健康 Redeemed prescription medicines to measure quality of life of patients with long-term conditions: a national cross-sectional study 通过已兑换的处方药衡量慢性病患者生活质量：一项全国性横断面研究 Henrik Hedegaard Pliess LarsenVolkert SiersmaAnne Holm Research 20 April 2026 Article: 335 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 属于专题合集：健康老龄化与长寿：预防医学和风险因素的作用 Viral shedding dynamics in coxsackievirus A6 hand, foot, and mouth disease: a prospective, individual-level analysis 柯萨奇病毒A6型手足口病的病毒排毒动态：一项前瞻性个体水平分析 Jiale MengYue ChengLu Long Research 18 April 2026 Article: 334 Mental health and wellbeing interventions for uniformed service personnel: a mixed methods systematic review 军警人员心理健康与福祉干预措施：一项混合方法系统综述 Jessica EatonHolly EllardAlan Simpson Research 17 April 2026 Article: 333 WISE-Therapy (What’s Important: Schedule and Engage) and bouldering psychotherapy for depression: A randomized clinical trial WISE-Therapy（智慧疗法）（重要之事：安排与参与）与抱石心理治疗用于抑郁症：一项随机临床试验 Johannes KornhuberPiotr LewczukKatharina Luttenberger Research 27 May 2026 Article: 332 Handgrip weakness is associated with motor cortex atrophy in rheumatoid arthritis: a cross-sectional study with a hand exercise intervention 握力减弱与类风湿关节炎患者运动皮层萎缩相关：一项包含手部运动干预的横断面研究 Amanda L GustafssonRolf A HeckemannCaroline Wasén Research 26 May 2026 Article: 331 Interpretable multimodal PET/CT-EHR fusion via mixture-of-experts for prognostic stratification in mantle cell lymphoma: a multicenter study 基于专家混合模型的可解释性多模态PET/CT-HER（电子健康记录）融合在套细胞淋巴瘤预后分层中的应用：一项多中心研究 Chong JiangZitong ZhangRong Tian Research 16 April 2026 Article: 330 Non-invasive diagnosis strategy integrating PSMA PET/CT and mpMRI for patients with suspected prostate cancer: a multi-center study 整合PSMA PET/CT与多参数MRI的无创诊断策略用于疑似前列腺癌患者：一项多中心研究 Yuhang WangYongxiang TangYi Cai Research 16 April 2026 Article: 329 Clinical benefit of tenecteplase despite failed recanalization in late-window ischemic stroke: a post hoc analysis of the TRACE-3 trial 晚期窗口缺血性卒中中即使再通失败，替奈普酶仍具临床获益：TRACE-3试验的事后分析 Zhengzhao LuZiran WangYongjun Wang Research 16 April 2026 Article: 328 Infant subcortical brain volumes associated with maternal obesity and diabetes: a large multicohort human study 婴儿皮层下脑容量与母亲肥胖及糖尿病相关：一项大型多队列人类研究 Ann M. AlexJerod M. RasmussenENIGMA-ORIGINs working group Research 16 April 2026 Article: 327 Cost-effectiveness of prehabilitation for elderly (pre-)frail patients prior to elective surgery compared to standard care - an economic evaluation from a societal perspective 择期手术前老年（衰弱前期/）衰弱患者预康复与标准护理的成本效益比较——一项基于社会视角的经济学评估 Tanja RombeyHelene EckhardtLukas Schöner Research 21 May 2026 Article: 326 Frozen melanoma tissues yield extracellular vesicles with preserved diagnostic and immunogenic properties 冷冻黑色素瘤组织可获得具有保存完好的诊断和免疫特性的细胞外囊泡 Daniele D´ArrigoKyong-Su ParkRossella Crescitelli Research 21 May 2026 Article: 325 Mechanisms underlying immunodynamics of layered defenses elicited by mRNA vaccination in children 儿童mRNA疫苗接种所引发的分层防御免疫动力学的潜在机制 Yiyu LiaoHoong Kai ChuaKeisuke Ejima Research 15 April 2026 Article: 324 Epigenetic aging markers in the association between frailty and mortality among U.S. adults 美国成年人虚弱与死亡率相关性中的表观遗传衰老标志物 May A. BeydounNicole Noren HootenAlan B. Zonderman Research 15 April 2026 Article: 323 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用 Evolution with age of the relationship between sex and post-COVID symptoms: a population-based cohort study 性别与新冠后遗症症状关系随年龄的演变：一项基于人群的队列研究 Anne PastorelloCécile Vuillermozfor the EpiCov study group Research 14 April 2026 Article: 322 Bowel cancer care in individuals with an intellectual disability: a population-based cohort study of symptoms, diagnostic pathways, treatment and survival 智力障碍个体的肠癌护理：症状、诊断路径、治疗及生存的基于人群的队列研究 Oliver John KennedyUmesh ChauhanDarren Mark Ashcroft Research 20 May 2026 Article: 321 Association of antiviral use for influenza among non-severe cases with subsequent hospitalization and mortality 非重症流感病例使用抗病毒药物与后续住院及死亡的关系 Taito KitanoShinya TsuzukiSayaka Yoshida Research 06 April 2026 Article: 320 Social and digital engagement associated with reduced depressive symptoms in adults aged 50 and older: a multi-country cohort study 社交及数字互动与50岁及以上成年人抑郁症状减少的关系：一项多国队列研究 Yaping WangLiyuan TaoJue Liu Research 07 April 2026 Article: 319 Fat-soluble vitamin deficiency in children with neurodevelopmental disorders: a cross-sectional study 神经发育障碍儿童脂溶性维生素缺乏：一项横断面研究 Jingjing RaoXiaomei WangChangzhen Li Research 08 April 2026 Article: 318 Part of 1 collection:Child and adolescent psychiatry 所属专题合集：儿童与青少年精神病学 Skeletal and cardiac muscle longitudinal associations in the Baltimore Longitudinal Study of Aging (BLSA) 巴尔的摩老龄化纵向研究（BLSA）中骨骼肌与心肌的纵向关联 Jie Jun WongFei GaoAngela S. Koh Research 06 April 2026 Article: 317 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学与风险因素的作用 Early repetitive transcranial magnetic stimulation for preventing chronic postoperative pain in older adults: a randomized clinical sub-study 早期重复经颅磁刺激预防老年患者慢性术后疼痛：一项随机临床子研究 Wei-Wei ZhouZhi YangChao-Chao Zhong Research 06 April 2026 Article: 316 Part of 1 collection:Neuromodulation in brain functional disorders 所属专题合集：脑功能障碍中的神经调控 Clinical epidemiology and risk prediction of unsuccessful treatment outcomes in pulmonary tuberculosis with diabetes mellitus 合并糖尿病的肺结核治疗失败结局的临床流行病学与风险预测 Ping LiFeilong LuJunjun Jiang Research 25 March 2026 Article: 315 Part of 1 collection:Diabetes and infectious disease 所属专题合集：糖尿病与感染性疾病 Spatiotemporal patterns of climate-sensitive vector-borne diseases in Bangladesh: leveraging machine learning and spatial regression for intervention strategies 孟加拉国气候敏感型虫媒传染病的时空格局：利用机器学习与空间回归制定干预策略 Md. Siddikur RahmanMd. Abu Bokkor ShiddikArman Hossain Chowdhury Research 13 April 2026 Article: 314 Part of 1 collection:Climate change and human health 所属专题合集：气候变化与人类健康 The association of pregnancy complications/risk factors with the development of cancer in women: an umbrella review 妊娠并发症/危险因素与女性癌症发生的关系：一项伞状综述 Jemma HealeyMegha SinghMairead Black Research 13 April 2026 Article: 313 Synergistic effects of obesity and type 2 diabetes on adiposity-related cancer risk across age strata 肥胖与2型糖尿病对不同年龄层肥胖相关癌症风险的协同效应 Alex E. HenneyMegan HeagueDaniel J. Cuthbertson Research 13 April 2026 Article: 312 Acute COVID-19 severity and impaired cognitive function up to 32months after diagnosis: an observational study 急性新冠严重程度与确诊后长达32个月的认知功能损害：一项观察性研究 Ingibjörg MagnúsdóttirAnders B. NygaardUnnur Anna Valdimarsdóttir Research 11 April 2026 Article: 311 Maternal macronutrient intake and gestational diabetes: systematic review of prospective observational studies and dose-response meta-analyses 孕产妇宏量营养素摄入与妊娠期糖尿病：前瞻性观察研究的系统综述及剂量反应荟萃分析 Cameron D. YoungMichael G. GarrattAndrew N. Reynolds Research 11 April 2026 Article: 310 Part of 1 collection:Diagnosis and management of gestational diabetes 所属专题合集：妊娠期糖尿病的诊断与管理 Global, regional, and national burden of colorectal cancer attributable to central obesity: a population attributable fraction analysis 中心性肥胖所致结直肠癌的全球、区域及国家负担：人群归因分数分析 Daniele PiovaniGisella FiglioliStefanos Bonovas Research 10 April 2026 Article: 309 Evaluating DNA methylation markers and extended HPV genotyping in first-void urine for detecting high-grade cervical lesions in HPV-positive women: a cross-sectional study 评估首段尿液中DNA甲基化标志物及扩展型HPV基因分型在HPV阳性女性中检测高级别宫颈病变的价值：一项横断面研究 Mette TranbergSeverien Van KeerRenske Steenbergen Research 10 April 2026 Article: 308 Targeted long-read genomic and epigenomic profiling enhances timely comprehensive variant discovery in hypotonia and muscle weakness 靶向长读长基因组与表观基因组测序提升低张力与肌无力的全面变异及时发现 Eman AbuijlanShruti SinhaAhmad Abou Tayoun Research 08 April 2026 Article: 307 Targeting immunosenescence in lung diseases: mechanistic insights and clinical interventions 靶向肺疾病中的免疫衰老：机制洞察与临床干预 Yin ZhangXianzhe YuFengming Luo Review 08 April 2026 Article: 306 Apolipoprotein C3 drives adverse cardiac remodeling in ischemic heart failure 载脂蛋白C3促进缺血性心力衰竭中的不良心脏重塑 Yufei HanYixue ZhaoXunde Xian Research 09 April 2026 Article: 305 Part of 1 collection:Cardiac immunity and inflammation 所属专题合集：心脏免疫与炎症 Causal modeling of school aversion in psychiatrically referred adolescents: a DoWhy-based analysis 转诊精神病科的青少年厌学情绪的因果模型：基于DoWhy的分析 Mengmeng ZhangXin MaMeijuan Wang Research 09 April 2026 Article: 304 Part of 1 collection:Child and adolescent psychiatry 所属专题合集：儿童与青少年精神病学 Aperiodic and periodic neural activity during sleep in autism spectrum disorders 自闭症谱系障碍睡眠中的非周期性和周期性神经活动 Noemi MazzoniEva-Maria KurzAndrea Caria Research 18 March 2026 Article: 303 Part of 1 collection:Sleep and mental health 所属专题合集：睡眠与心理健康 Association and mediating pathways between intergenerational educational mobility and depressive symptoms: findings from high- and middle-income countries 代际教育流动性与抑郁症状之间的关联及中介路径：来自高收入和中等收入国家的发现 Yingchao ZengSimu HuangChihua Li Research 02 April 2026 Article: 302 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用 Scoping review on the prioritisation of high-consequence infectious pathogens for research preparedness and response to health emergencies 关于优先研究高后果性感染病原体以应对突发卫生事件的研究准备与响应的范围综述 Nicolas PulikHolly SadlerAlice Norton Research 01 April 2026 Article: 301 Serum uric acid levels among children and adolescents in China: percentile reference values and national prevalence estimates of hyperuricemia 中国儿童和青少年血清尿酸水平：高尿酸血症的百分位参考值和全国患病率估计 Qianrang ZhuXin’nan ZongMin Zhao Research 31 March 2026 Article: 300 Waist circumference and grip strength and their joint relations to type 2 diabetes incidence in UK Biobank 腰围和握力及其与英国生物银行中2型糖尿病发病风险的联合关系 Johanna WirlerMichael J. SteinMichael F. Leitzmann Research 07 May 2026 Article: 299 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用 Targeting cardiomyocyte-derived extracellular vesicle miR-574-5p protects against cognitive impairment induced by ischemia–reperfusion 靶向心肌细胞衍生的外泌体miR-574-5p可预防缺血再灌注引起的认知障碍 Erya ChenXiaoyu ZhuChan Chen Research 19 March 2026 Article: 298 Motor-related reorganization in left inferior frontal gyrus after subcortical stroke: neurochemical basis and response to targeted neuromodulation 皮层下卒中后左侧额下回的运动相关重组：神经化学基础及靶向神经调控的反应 Wenjun HongYaxi WangZhiyong Zhao Research 27 March 2026 Article: 297 Part of 1 collection:Neuromodulation in brain functional disorders 所属专题合集：脑功能疾病中的神经调控 Association between ambient temperature and childhood vaccination coverage in low- and middle-income countries 中低收入国家环境温度与儿童疫苗接种覆盖率之间的关联 Hongqiu ZhengYixiang ZhuZhiyuan Hou Research 11 March 2026 Article: 296 Part of 1 collection:Climate change and human health 所属专题合集：气候变化与人类健康 White matter changes in reward circuits of amyotrophic lateral sclerosis: a fixel-based study of appetite loss 肌萎缩侧索硬化症奖赏回路白质改变：基于纤维束的食欲减退研究 Jeryn ChangHarry LipscombeThomas B. Shaw Research 27 March 2026 Article: 295 Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates 所属专题合集：肌萎缩侧索硬化症：最新进展与新动态 The adverse effects associated with tirzepatide use in patients at increased risk of cardiovascular events: a systematic review with meta-analysis and Trial Sequential Analysis 替西帕肽在心血管事件风险增加患者中的不良反应：一项系统综述与荟萃分析及试验序贯分析 Christina Dam Bjerregaard SillassenPascal FaltermeierJanus Christian Jakobsen Research 27 March 2026 Article: 294 Part of 1 collection:Weight loss interventions and their health impacts 所属专题合集：减肥干预措施及其健康影响 Age-related genomic characterization and therapeutic targets in Chinese breast cancer: insights from prospective targeted sequencing and clinical data analysis 中国乳腺癌年龄相关基因组特征及治疗靶点：前瞻性靶向测序与临床数据分析的见解 Xin-Yi SuiXiao-Qing SongLei Fan Research 27 March 2026 Article: 293 Impact of the family cohesion-centered frailty intervention on older gastric cancer patients: a non-randomized controlled trial 以家庭凝聚力为中心的衰弱干预对老年胃癌患者的影响：一项非随机对照试验 Yinning GuoYimeng ChenQin Xu Research 27 March 2026 Article: 292 Part of 1 collection:Clinical trials for gastrointestinal cancer 所属专题合集：胃肠道癌症临床试验 Perceptions of HPV vaccination: a qualitative study with adolescents, parents, school staff, and pharmacists 对HPV疫苗接种的看法：一项针对青少年、家长、学校工作人员和药剂师的定性研究 Laurène HoutinLucia RomoClémence Brun Research 26 March 2026 Article: 291 Risk classification of internet gaming disorder based on neurobiological subtyping from impulsivity-linked resting-state functional connectivity: a longitudinal design study 基于冲动性相关静息态功能连接神经生物学亚型的网络游戏障碍风险分类：一项纵向设计研究 Xinwen WenJiahao ZhaoKai Yuan Research 26 March 2026 Article: 290 Part of 1 collection:Child and adolescent psychiatry 所属专题合集：儿童与青少年精神病学 Trainee-delivered school-based intervention with guided narrative writing for adolescent anxiety and depression: a cluster randomized controlled trial 由受训者实施的、基于学校的、以引导性叙事写作为干预手段的青少年焦虑和抑郁干预：一项整群随机对照试验 Yixuan WangMuyang LiYinyin Zang Research 26 March 2026 Article: 289 Part of 1 collection:Child and adolescent psychiatry 所属专题合集：儿童与青少年精神病学 Nourishing future generations: the critical role of healthy school lunches and strategic food procurement 滋养未来一代：健康学校午餐和战略性食品采购的关键作用 Aurora Perez-CornagoCarmen Piernas Comment 05 May 2026 Article: 288 Multi-omics analysis reveals sex-specific etiology of human muscle weakness following musculoskeletal injury 多组学分析揭示人类骨骼肌损伤后肌无力的性别特异性病因 Alexander R. KeebleAllison M. OwenChristopher S. Fry Research 26 March 2026 Article: 287 Public health impact of catch-up vaccination or additional booster doses with pre-erythrocytic malaria vaccine R21/Matrix-M: a modelling study 使用红细胞前期疟疾疫苗R21/Matrix-M进行追赶接种或额外加强接种的公共卫生影响：一项建模研究 Kelly McCainHillary M. TopazianAzra C. Ghani Research 25 March 2026 Article: 286 A digital-health multidomain lifestyle management framework and its associations with cardiometabolic health: a real-world observational study 数字健康多领域生活方式管理框架及其与心脏代谢健康的关联：一项现实观察性研究 Han XiaoKexin DingDafang Chen Research 25 March 2026 Article: 285 Bilateral sequential accelerated theta-burst stimulation for treatment-resistant depression: an open-label randomized controlled trial 双侧序贯加速θ波爆发刺激治疗难治性抑郁症：一项开放标签随机对照试验 Xingxing LiEnze TangDongsheng Zhou Research 25 March 2026 Article: 284 Part of 1 collection:Neuromodulation in brain functional disorders 所属专题合集：脑功能疾病中的神经调控 Digenic inheritance of mutations in SPG7 and AFG3L2 causes motor neuron and cerebellar disorders SPG7和AFG3L2基因突变双基因遗传导致运动神经元和小脑疾病 Mehrdad A. EstiarEric YuZiv Gan-Or Research 24 March 2026 Article: 283 Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates 所属专题合集：肌萎缩侧索硬化症：最新进展与新颖动态 Social isolation and 59 common health conditions: insights from observational and genetics analyses 社交孤立与59种常见健康状况：观察性研究与遗传学分析的见解 Sizhi AiQiqi WuYannis Yan Liang Research 23 March 2026 Article: 282 Clustering depression subgroups based on dorsolateral prefrontal-subgenual anterior cingulate cortex peak functional connectivity reveals different symptom profiles and TMS treatment outcomes 基于背外侧前额叶-膝下前扣带回皮层峰值功能连接性的抑郁亚组聚类分析揭示了不同的症状特征和经颅磁刺激（TMS）治疗结果 Gai KongSirui WangYingying Tang Research 23 March 2026 Article: 281 Robust human genetic evidence supporting causal effects of FGF21 on reducing alcohol consuming behaviours 人类遗传学有力证据支持成纤维细胞生长因子21（FGF21）对减少饮酒行为的因果效应 Héléne T. CronjéSile HuDipender Gill Research 23 March 2026 Article: 280 Artificial intelligence-based prediction of fetal hypoxia: a multicenter model development and nationwide AI-human comparison 基于人工智能的胎儿缺氧预测：多中心模型开发及全国范围的人工智能与人类对比 Suiwen LinXiaodan DiBin Liu Research 21 March 2026 Article: 279 Efficacy and long-term engagement of a WeChat-integrated modality versus a traditional quitline on smoking cessation in China: a randomised controlled trial 微信整合模式与传统戒烟热线在中国戒烟中的疗效及长期参与度：一项随机对照试验 Shuilian ChuDi ZhangLirong Liang Research 21 March 2026 Article: 278 A culturally-safe primary care intervention for migrant/refugee women suffering domestic violence and abuse: HARMONY—a pragmatic cluster randomised controlled trial 针对遭受家庭暴力和虐待的移民/难民妇女的文化安全初级护理干预措施：HARMONY——一项实用性整群随机对照试验 Angela J. TaftFelicity YoungGene Feder Research 21 March 2026 Article: 277 Development, integration, retention, and career progression of physician associates/assistants in UK NHS hospitals and clinical teams: a multiple-case qualitative study 英国国家医疗服务体系（NHS）医院及临床团队中医师助理/协理医师的发展、整合、留任及职业晋升：一项多案例定性研究 Yingxi ZhaoRhys SwainstonThe ROADMAP-PA collaborator group Research 20 April 2026 Article: 276 Compound climate extreme events and associated health impacts: a scoping review 复合气候极端事件及其相关健康影响：一项范围性综述 Shifali MathewsCaitlin WalkerJaime Madrigano Research 20 March 2026 Article: 275 Part of 1 collection:Climate change and human health 所属专题合集：气候变化与人类健康 Smoking history, eligibility for lung cancer screening and risk of death by lung cancer or other causes -- a longitudinal, time-variable analysis of the EPIC-Heidelberg cohort 吸烟史、肺癌筛查资格以及死于肺癌或其他原因的风险——对EPIC-海德堡队列的纵向、时变分析 Yue ChenSrimanti DuttaRudolf Kaaks Research 28 April 2026 Article: 274 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用 Cortical functional hierarchy disruption following subcortical stroke 皮质功能层级在皮层下卒中后的破坏 Ke WuGang LiuGaolang Gong Research 19 March 2026 Article: 273 Characterizing the effects of genetic liability to autoimmune conditions on pregnancy outcomes using Mendelian randomization 利用孟德尔随机化方法表征遗传易感性对自身免疫性疾病患者妊娠结局的影响 Elisabeth AitonNancy S. McBrideMaria Carolina Borges Research 19 March 2026 Article: 272 Dystrophin-gene mutation location influences severity of electroretinogram defects in mouse models of Duchenne muscular dystrophy 杜氏肌营养不良症小鼠模型中，肌营养不良蛋白基因突变位置对视网膜电图缺陷严重程度的影响 André Maurício Passos LiberMirella BarboniCyrille Vaillend Research 25 April 2026 Article: 271 Personalizing the treatment of head and neck cancer in vitro: The 3D-OTC model 体外个性化治疗头颈部肿瘤：三维器官芯片（3D-OTC）模型 Fabian StögbauerTobias WeiserBarbara Wollenberg Research 25 April 2026 Article: 270 Part of 1 collection:Organoids: connecting molecular insights and clinical practice 所属专题合集：类器官：连接分子见解与临床实践 Risk factor profiles for infections in individuals with type 2 diabetes: a prospective cohort study 2型糖尿病患者感染的风险因素特征：一项前瞻性队列研究 Han-Cheng YuJi-Juan ZhangYun-Fei Liao Research 18 March 2026 Article: 269 Part of 1 collection:Diabetes and infectious disease 所属专题合集：糖尿病与感染性疾病 Cause-specific years of life lost attributable to non-optimal body mass index by county, sex, race, and ethnicity in the USA, 2000–2019: a systematic analysis of health disparities 2000-2019年美国按县、性别、种族和民族划分的非最佳体重指数导致的特定原因寿命损失年数：一项关于健康差异的系统分析 GBD US Health Disparities CollaboratorsFarah MouhannaLaura Dwyer-Lindgren Research 18 March 2026 Article: 268 Global and regional prevalence, burden, and risk factors for MASLD in children and adolescents aged 5 to 24years: a systematic review, meta-analysis, and modeling study 全球和区域5至24岁儿童和青少年代谢相关脂肪性肝病（MASLD）的患病率、负担及风险因素：一项系统综述、荟萃分析和建模研究 Yunfei LiuShan CaiSusan M. Sawyer Research 18 March 2026 Article: 267 Relative leukocyte telomere length and the risk of lung cancer progression in individuals with pulmonary nodules 相对白细胞端粒长度与肺结节患者肺癌进展风险的关系 Yuanyuan WuDong SunFeifei Cheng Research 18 March 2026 Article: 266 Effects of Tai Chi combined with transcranial direct current stimulation on pain in knee osteoarthritis: a randomized controlled neuroimaging trial 太极拳结合经颅直流电刺激对膝骨关节炎疼痛的影响：一项随机对照神经影像学试验 Xuefeng LiuTong TangJing Tao Research 17 March 2026 Article: 265 DNA hypermethylation of choline kinases drives blockage of choline-phosphatidylcholine biosynthesis: lipidomic biomarkers and epigenetic insights of hepatic steatosis induced by arsenic 胆碱激酶DNA高甲基化驱动胆碱-磷脂酰胆碱生物合成受阻：砷诱导的肝脂肪变性的脂质组学生物标志物及表观遗传学见解 Qiwen FuQi WangLu Ma Research 17 March 2026 Article: 264 Dynamics of Mpox epidemics by the interplay of COVID-19 pandemic in Africa 非洲猴痘（Mpox）流行与新冠肺炎（COVID-19）大流行相互作用下的猴痘流行病学动态 Oyewole K. OyedeleNifarta P. AndrewAlash’le Abimiku Research 17 March 2026 Article: 263 Part of 1 collection:Mpox: Epidemiology, prevention, and treatment 所属专题合集：猴痘：流行病学、预防和治疗 SPP1high fibrogenic macrophages mediate protective fibrotic remodeling and promote vascular stability in hypertension-associated aortic dissection SPP1高表达成纤维性巨噬细胞介导保护性纤维化重塑并促进高血压相关主动脉夹层的血管稳定性 Shuai ZhaoXiumeng HuaJiangping Song Research 16 March 2026 Article: 262 Longitudinal associations between body fat mass and cardiovascular outcomes among Chinese children: mediation by cardiometabolic risk factors 中国儿童身体脂肪量与心血管结局之间的纵向关联：通过心脏代谢风险因素的中介作用 Hui YangQin LiuBo Xi Research 16 March 2026 Article: 261 The timing of the commencement of pulmonary rehabilitation in hospitalized patients with acute exacerbation of COPD: a systematic review and network meta-analysis 住院慢性阻塞性肺疾病急性加重患者开始肺康复治疗的时机：一项系统综述和网络荟萃分析 Peilin JiaHailong ZhangLongyu Wang Research 16 March 2026 Article: 260 Correction: Vegetable intake and the risk of bladder cancer in the BLadder Cancer Epidemiology and Nutritional Determinants (BLEND) international study 更正：膀胱癌流行病学和营养决定因素（BLEND）国际研究中蔬菜摄入量与膀胱癌风险的关系 Evan Yi-Wen YuAnke WesseliusMaurice P. Zeegers Correction 22 April 2026 Article: 259 Comparative efficacy of neoadjuvant short-course versus long-course radiotherapy-based regimens with or without immunotherapy for locally advanced pMMR rectal cancer: a systematic review and network meta-analysis 基于放疗的新辅助短疗程与长疗程治疗方案（联合或不联合免疫治疗）对局部晚期错配修复功能正常（pMMR）型直肠癌的疗效比较：一项系统综述与网状荟萃分析 Liqing LiXiaoyao MengTingshi Su Research 14 March 2026 Article: 258 Association between bariatric surgery and long-term ability to perform household tasks in the Swedish Obese Subjects study: a controlled prospective cohort study 瑞典肥胖受试者研究：减肥手术与长期从事家务能力之间的关联——一项对照前瞻性队列研究 Petra BrembeckJohanna C. Andersson-AssarssonPer-Arne Svensson Research 18 April 2026 Article: 257 Part of 1 collection:Weight loss interventions and their health impacts 所属专题合集：减重干预措施及其健康影响 The role of male foetal sex on maternal and neonatal outcomes in pregnancies complicated by gestational diabetes—secondary analysis of a randomised placebo controlled clinical trial of metformin in gestational diabetes (EMERGE) 男性胎儿性别对妊娠期糖尿病合并妊娠的母婴预后的影响——妊娠期糖尿病二甲双胍随机对照安慰剂临床试验（EMERGE）的二次分析 Christine NewmanAlberto Alvarez-IglesiasFidelma Dunne Research 12 March 2026 Article: 256 Part of 1 collection:Diagnosis and management of gestational diabetes 所属专题合集：妊娠期糖尿病的诊断与管理 Downregulated lysyl oxidase in plasma extracellular vesicles: a biomarker linked to brain metastasis risk in lung adenocarcinoma 血浆细胞外囊泡中赖氨酰氧化酶表达下调：与肺腺癌脑转移风险相关的生物标志物 Jing LiYu PeiYi Liu Research 12 March 2026 Article: 255 The influence of age-dependent susceptibility on RSV transmission dynamics and immunisation population-level impact 年龄依赖性易感性对呼吸道合胞病毒（RSV）传播动力学及免疫接种人群层面影响的研究 Chenkai ZhaoYuhe ZhangHarish Nair Research 11 March 2026 Article: 254 A human-derived Bacteroides strain attenuates depressive-like behavior in a rat model of social defeat-induced stress 一株人源拟杆菌属菌株可减轻社会挫败诱导应激大鼠模型的抑郁样行为 Marisol I. DothardMariaelena CaboniPhilip Strandwitz Research 10 March 2026 Article: 253 Adverse events in both childhood and adulthood are associated with molecular, clinical and functional markers of ageing 童年和成年期的不良事件均与衰老的分子、临床和功能标志物相关 Monica AasThole H HoppenJulian Mutz Research 28 April 2026 Article: 252 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用 Genetic predisposition to high BMI, ultra-processed food consumptions in childhood, and adiposity in young adulthood: a 17-year prospective cohort study of 3061 individuals 高BMI遗传易感性、儿童期超加工食品摄入与成年早期肥胖：一项对3061例个体进行的为期17年的前瞻性队列研究 Ziyi ZhouQiaosen ChenFrederick K. Ho Research 16 April 2026 Article: 251 Enhanced predictive performance of artificial intelligence in individualized ovarian stimulation of in vitro fertilization: a retrospective cohort study 人工智能在体外受精个体化卵巢刺激中的预测性能提升：一项回顾性队列研究 Guiquan WangMinyue TangYimin Zhu Research 10 March 2026 Article: 250 PCDSOS: a novel clinical predictive tool for screening primary ciliary dyskinesia in adult bronchiectasis patients—a multicenter derivation and external validation study PCDSOS：一种用于筛查成人支气管扩张症患者原发性纤毛运动障碍的新型临床预测工具——一项多中心推导及外部验证研究 Wangji ZhouLin WangXinlun Tian Research 10 March 2026 Article: 249 Detection rate and mutational landscape in extracranial arteriovenous malformations: a cohort study 颅外动静脉畸形的检出率及突变谱：一项队列研究 Vanessa F. SchmidtDenny Schanzefor the APOLLON Investigators Research 16 April 2026 Article: 248 Kinetics of antibodies and risk of respiratory syncytial virus infection: a longitudinal cohort in Taizhou City, eastern China 抗体动力学与呼吸道合胞病毒感染风险：中国东部台州市的一项纵向队列研究 Qiang WangDavid HodgsonWeibing Wang Research 09 March 2026 Article: 247 Cell therapy strategies for organ regeneration 器官再生的细胞治疗策略 L. PapamichailL. J. W. van der LaanM. J. Hoogduijn Review 25 February 2026 Article: 246 Transcutaneous spinal cord stimulation combined with robot-assisted gait training to improve mobility and balance in spinal cord injury: intramuscular electromyography as a biomarker for functional recovery 经皮脊髓电刺激联合机器人辅助步态训练改善脊髓损伤患者的行动能力和平衡能力：肌内肌电图作为功能恢复的生物标志物 Abdul RashadHe XijingMuhammad Asif Registered Report 09 March 2026 Article: 245 Neoadjuvant camrelizumab combined with radiotherapy as a chemotherapy-sparing approach for resectable locally advanced esophageal squamous cell carcinoma: a phase II clinical trial (ESOCORT-NIRT) 新辅助卡瑞利珠单抗联合放疗作为可切除局部晚期食管鳞癌的免化疗方案：一项II期临床试验（ESOCORT-NIRT） Maohui ChenYizhou HuangBin Zheng Research 09 March 2026 Article: 244 FLASH radiotherapy preserves systemic and tissue homeostasis while maintaining antitumor efficacy FLASH放疗在保持抗肿瘤疗效的同时维持全身及组织稳态 Giulia FuriniEduarda Mota da SilvaMargherita Maffei Research 26 February 2026 Article: 243 fMRI-guided V1-targeted rTMS improves depressive symptoms in adolescents and young adults with bipolar disorder: a double-blind randomized controlled trial 功能磁共振成像引导的V1区靶向重复经颅磁刺激改善青少年及青年双相情感障碍患者的抑郁症状：一项双盲随机对照试验 Xudong ZhaoHetong ZhouMinmin Wang Research 07 March 2026 Article: 242 Part of 1 collection:Child and adolescent psychiatry 所属专题合集：儿童及青少年精神病学 Impairment of brain short association fibers across clinical stages in amyotrophic lateral sclerosis: a new biomarker mirroring disease progression 肌萎缩侧索硬化症临床各阶段脑短联结纤维受损情况：一种反映疾病进展的新型生物标志物 Nao-Xin HuangZi-Wei CaiHua-Jun Chen Research 06 March 2026 Article: 241 Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates 所属专题合集：肌萎缩侧索硬化症：最新进展与新动态 Social frailty and the risk of progression from health to physical, psychological, and cognitive multimorbidity: a prospective multi-cohort study 社会脆弱性与从健康状态进展至身体、心理及认知多病共存状态的风险：一项前瞻性多队列研究 Yaguan ZhouHtet Lin HtunYi Guo Research 06 March 2026 Article: 240 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学及风险因素的作用 Association between early life constituent-specific PM2.5 exposure and child development and the moderating role of greenness: a nationwide study in China 中国全国范围内早期生命特定成分PM2.5暴露与儿童发育的关联及绿地调节作用的研究 Ruili LiXiaoguo ZhengXiaoning Lei Research 06 March 2026 Article: 239 Part of 1 collection:Child and adolescent psychiatry 所属专题合集：儿童及青少年精神病学 Intravenous thrombolysis versus standard medical therapy in minor stroke patients with large vessel severe stenosis or occlusion: a systematic review and meta-analysis 静脉溶栓与标准药物治疗轻型卒中合并大血管重度狭窄或闭塞患者的系统综述与荟萃分析 Tianhao ZhangLin TongZhigang Liang Research 06 March 2026 Article: 238 Long-term risk of offspring type 1 and type 2 diabetes following maternal gestational diabetes mellitus: a nationwide birth cohort study with 10-year follow-up 母亲妊娠期糖尿病后子女患1型和2型糖尿病的长期风险：一项为期10年随访的全国出生队列研究 Joon Ho MoonHan Na JungSung Hee Choi Research 06 March 2026 Article: 237 Part of 1 collection:Diagnosis and management of gestational diabetes 所属专题合集：妊娠期糖尿病的诊断与治疗 Parental income in childhood and health outcomes across age groups: a register-based study from Norway 童年期父母收入与各年龄段健康结局：一项基于挪威登记数据的研究 Bjørn-Atle RemeHans Fredrik SundeJonathan Wörn Research 06 March 2026 Article: 236 AI-based quality control was associated with improved fetal ultrasound image quality in low-resource settings: a real-world multicenter study from West China 基于人工智能的质量控制可改善低资源环境下胎儿超声图像质量：一项来自中国西部的现实多中心研究 Jianxin ZhaoYao TangYong Huang Research 06 March 2026 Article: 235 Reply to: Intraoperative use of sodium oxybate to prevent post-operative delirium in older patients undergoing major orthopedic surgery 回复：术中使用羟丁酸钠预防老年患者接受大骨科手术后谵妄 Meiying CuiHang XuePing Zhao Matters Arising 13 April 2026 Article: 234 Hypothesis-free evaluation of circulating metabolome provides cell-specific insights regarding the role of energy substrate availability in amyotrophic lateral sclerosis 无假设的循环代谢组学评估为肌萎缩侧索硬化症中能量底物可用性的细胞特异性作用提供见解 Elham AlhathliJohnathan Cooper-KnockPamela J. Shaw Research 06 March 2026 Article: 233 Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates 所属专题合集：肌萎缩侧索硬化症：最新进展与新动态 Intraoperative use of sodium oxybate to prevent postoperative delirium in older patients undergoing major orthopedic surgery 术中使用羟丁酸钠预防老年患者接受大骨科手术后谵妄 Fu-Shan XueDan-Feng WangXiao-Chun Zheng Matters Arising 13 April 2026 Article: 232 Statin therapy and stroke risk in patients with hypercholesterolaemia: a population-based longitudinal study using electronic health records in South London 他汀类药物治疗与高胆固醇血症患者卒中风险：一项基于南伦敦电子健康记录的纵向人群研究 Marc DelordAbdel Douiri Research 05 March 2026 Article: 231 Thermal ablation versus hepatectomy for solitary colorectal liver metastases up to 5 cm: a multicenter target trial emulation on safety, efficacy, and cost-effectiveness 热消融与肝切除术治疗直径达5厘米的孤立性结直肠癌肝转移：一项关于安全性、疗效及成本效益的多中心目标试验模拟研究 Jianming LiLu LiPing Liang Research 05 March 2026 Article: 230 Why hyperinsulinemia is detrimental to weight loss: insights from type 1 diabetes 为何高胰岛素血症不利于减重：来自1型糖尿病的见解 Stephan MartinKerstin KempfHubert Kolb Debate 10 April 2026 Article: 229 Part of 1 collection:Weight loss interventions and their health impacts 所属专题合集：减重干预措施及其健康影响 Interventions to prevent and treat multiple long-term conditions and their consequences across the life course: concepts and definitions 预防和治疗多种长期疾病及其在生命周期中后果的干预措施：概念与定义 Miles D. WithamGuruprasad P. AithalThe Multiple Long-Term Conditions Cross-NIHR Collaboration Interventions and Prevention Workstream Forum 10 April 2026 Article: 228 Effectiveness of nirmatrelvir/ritonavir and molnupiravir on post-COVID diabetes risk among an older adult cohort: a target trial emulation study 奈玛特韦/利托那韦和莫努匹韦对老年人群新冠后糖尿病风险的影响：一项目标试验模拟研究 Zihao GuoYuchen WeiKa Chun Chong Research 17 March 2026 Article: 227 Part of 1 collection:Diabetes and infectious disease 所属专题合集：糖尿病与传染病 Iron deficiency and dementia risk: evidence from the Swedish population-based cohort study AMORIS 瑞典基于人群的队列研究AMORIS中铁缺乏与痴呆风险的证据 Mozhu DingAlexandra WennbergKarin Modig Research 08 April 2026 Article: 226 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用 Effects of ultrasound-guided stellate ganglion block in poststroke bulbar palsy: a double-blind placebo-controlled trial 超声引导下星状神经节阻滞对脑卒中后球麻痹的影响：一项双盲安慰剂对照试验 Hongji ZengWeihong ZhangXi Zeng Research 04 March 2026 Article: 225 Dual-utility ctDNA in diffuse large B-cell lymphoma: integrated genotyping unveils minimal residual disease dynamics and subtype-specific clonal evolution 双用途循环肿瘤DNA在弥漫性大B细胞淋巴瘤中的应用：整合基因分型揭示微小残留病灶动态变化及亚型特异性克隆演变 Jin-Hua LiangYi-Fan WuWei Xu Research 04 March 2026 Article: 224 Risks of non-breast, non-ovarian cancers for BRCA1 and BRCA2pathogenic variant carriers: a prospective cohort study BRCA1和BRCA2致病性变异携带者患非乳腺、非卵巢癌的风险：一项前瞻性队列研究 Ruotong YangRobert J. MacInnisShuai Li Research 04 March 2026 Article: 223 Cardiovascular outcomes of intensive blood pressure control in patients with and without metabolic dysfunction-associated fatty liver disease: post hoc analysis of the CRHCP trial 在伴有和不伴有代谢功能障碍相关脂肪性肝病的患者中，强化血压控制的心血管预后：CRHCP试验的事后分析 Songyue LiuYangzhi YinXiaofan Guo Research 04 March 2026 Article: 222 The role of COPD and inhaled corticosteroids in major adverse cardiovascular events in cardiovascular-kidney-metabolic populations 慢性阻塞性肺疾病和吸入性糖皮质激素在心血管-肾脏-代谢人群主要不良心血管事件中的作用 Anne E. IoannidesEmily L. GraulJennifer K. Quint Research 04 March 2026 Article: 221 Ethnic differences in the burden of cardiovascular disease risk factors among adult residents of London: the TOGETHER study 伦敦成年居民心血管疾病风险因素负担的种族差异：TOGETHER研究 Fotios BarkasMalo DirouKausik K. Ray Research 03 March 2026 Article: 220 Development of a novel prognostic assessment tool for recurrent respiratory papillomatosis 复发性呼吸道乳头瘤病新型预后评估工具的开发 Satoshi YamadaTaro IkegamiKiyoshi Misawa Research 16 April 2026 Article: 219 Response to: Matters Arising in relation to “Evaluating agreement between individual nutrition randomised controlled trials and cohort studies – a meta-epidemiological study” 针对“评估个体营养随机对照试验与队列研究之间的一致性——一项元流行病学研究”的相关问题探讨 Julia StadelmaierGina BantleLukas Schwingshackl Matters Arising 09 April 2026 Article: 218 Concordance between nutritional cohorts and randomized trials: biological confirmation or statistical consequence? A re-analysis of Stadelmaier et al. 营养队列研究与随机试验之间的一致性：生物学证实还是统计学结果？对Stadelmaier等人的研究再分析 Matthew CalkinsIsaac NúñezAdrian Soto-Mota Matters Arising 09 April 2026 Article: 217 Multimorbidity patterns and 15-year trajectories of physical performance: a population-based study 多病共存模式与15年身体机能变化轨迹：一项基于人群的研究 Francesco PalmeseDavide Liborio VetranoFederico Triolo Research 25 March 2026 Article: 216 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用 The need for clinical studies assessing whether weight loss improves functional outcome after stroke in diabetes 评估减肥是否改善糖尿病患者中风后功能预后的临床研究需求 Ellen VercalsterenMichael V. MazyaCesare Patrone Debate 24 March 2026 Article: 215 Targeting STE20-type kinase MST3 improves metabolic dysfunction-associated steatohepatitis without affecting hepatocellular carcinoma development in mice 靶向STE20型激酶MST3可改善小鼠代谢功能障碍相关脂肪性肝炎，且不影响肝细胞癌的发展 Jingjing ZhangXiangdong GongyeMargit Mahlapuu Research 24 March 2026 Article: 214 Multimorbidity patterns and the subsequent risk of albuminuria: findings from the Stockholm Creatinine Measurements (SCREAM) project 多病共存模式与后续白蛋白尿风险：来自斯德哥尔摩肌酐测量（SCREAM）项目的研究结果 Giorgi BeridzePatrick B. MarkJuan-Jesus Carrero Research 24 March 2026 Article: 213 Myeloid-derived immunosuppression of chimeric antigen receptor T cells in the neuronal microenvironment of glioblastoma 胶质母细胞瘤神经元微环境中髓系来源的免疫抑制对嵌合抗原受体T细胞的影响 Junyi ZhangJasmin von EhrYahaya A. Yabo Research 13 March 2026 Article: 212 Associations of genetically predicted interleukin-6 and tumor necrosis factor signaling pathways with mortality among persons with colorectal cancer: a two-sample Mendelian randomization 基因预测的白细胞介素-6和肿瘤坏死因子信号通路与结直肠癌患者死亡率之间的关联：一项双样本孟德尔随机化研究 Martina BoukaKatharina NimptschTobias Pischon Research 06 March 2026 Article: 211 Disruption of the angiopoietin-like system connects lipid homeostasis and hypothalamic dysfunction in ALS 血管生成素样系统紊乱将肌萎缩侧索硬化症中的脂质稳态与下丘脑功能障碍关联起来 Sruthi Sankari KrishnamurthyAdriana Zardini BuzattoFrancesco Roselli Research 03 March 2026 Article: 210 Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates 所属专题合集：肌萎缩侧索硬化症：最新进展与新动态 Day+30 detection of minimal residual FLT3-ITD by high-sensitivity PCR-NGS predicts relapse risk and guides post-transplant maintenance in AML 移植后第30天通过高灵敏度PCR-NGS检测微小残留FLT3-ITD可预测急性髓系白血病（AML）复发风险并指导移植后维持治疗 Shan JiangDan FengErlie Jiang Research 03 March 2026 Article: 209 Early childhood weight gain and alanine aminotransferase at age 8: an adjunct study of the Japan Environment and Children’s Study 幼儿期体重增长与8岁时丙氨酸氨基转移酶水平：日本环境与儿童研究的一项辅助研究 Naw Awn J-PKeiko YamasakiNarufumi Suganuma Research 03 March 2026 Article: 208 Anti-CD19 chimeric antigen receptor T-cell therapy for relapsed or refractory Philadelphia chromosome-positive B cell acute lymphoblastic leukemia: a multicenter retrospective study 抗CD19嵌合抗原受体T细胞疗法治疗复发或难治性费城染色体阳性B细胞急性淋巴细胞白血病：一项多中心回顾性研究 Jinglei YuFengmei SongGuoqing Wei Research 03 March 2026 Article: 207 Identification of cryosensitive niches and a targetable FOS/AP‑1 program in the human ovarian cortex by single‑cell and spatial transcriptomics 通过单细胞和空间转录组学鉴定人类卵巢皮质中的冷敏感生态位及可靶向的FOS/AP-1程序 Fanghao GuoDi SunWen Li Research 03 March 2026 Article: 206 Neoadjuvant camrelizumab combined with metronomic chemotherapy in patients with advanced esophageal squamous cell carcinoma: a pilot randomized phase 2 trial 卡瑞利珠单抗联合节拍化疗新辅助治疗晚期食管鳞状细胞癌：一项随机2期初步试验 Zhiming ChenWenshuai LiJie Liu Research 03 March 2026 Article: 205 Part of 1 collection:Clinical trials for gastrointestinal cancer 所属专题合集：胃肠道癌症临床试验 Vericiguat for endothelial dysfunction and CRT response in non-responders: the VERCET prospective observational study 维利西呱治疗无反应者的内皮功能障碍和心脏再同步化治疗（CRT）反应：VERCET前瞻性观察研究 Celestino SarduLudovica Vittoria MarfellaRaffaele Marfella Research 03 March 2026 Article: 204 Part of 1 collection:Cardiomyopathy and cardiac arrhythmias 所属专题合集：心肌病和心律失常 Assessment of antibody responses to Anopheles SG6-P1 and Aedes N-term 34kDa salivary peptides: a randomised human-challenge trial of controlled exposures to vector bites 评估针对按蚊SG6-P1和伊蚊N端34 kDa唾液肽的抗体反应：一项对媒介叮咬进行可控暴露的随机人体挑战试验 Victor ChaumeauEllen A. KearneyFreya J. I. Fowkes Research 02 March 2026 Article: 203 Is random biopsy necessary for normal esophageal mucosa during chromoendoscopy? Evidence from a population-based cohort study 在色素内镜检查过程中，对于正常食管黏膜是否有必要进行随机活检？一项基于人群的队列研究证据 Wenlei YangMengfei LiuYang Ke Research 02 March 2026 Article: 202 Sinusoidal cell–derived biomarker scores predict diagnosis and prognosis in chronic liver disease 窦状隙细胞来源的生物标志物评分可预测慢性肝病的诊断和预后 Sergi Guixé-MuntetAnabel Fernández-IglesiasJordi Gracia-Sancho Research 28 February 2026 Article: 201 Anticholinergic drug burden and incident cardiovascular events: a population-based study 抗胆碱能药物负担与新发心血管事件：一项基于人群的研究 Nanbo ZhuMaria EriksdotterHong Xu Research 28 February 2026 Article: 200 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用 Sensitive periods of BMI change from childhood to adulthood on subclinical cardiovascular outcomes: a 36-year prospective cohort study 从儿童期到成年期体重指数（BMI）变化对亚临床心血管结局影响的敏感期：一项为期36年的前瞻性队列研究 Hui YangTongshuai GuoJianjun Mu Research 27 February 2026 Article: 199 Feasibility and preliminary efficacy of an art-making program to manage fear of cancer recurrence (AM-I-FCR) in lung cancer patients: a randomized controlled pilot study 艺术创作项目（AM-I-FCR）管理肺癌患者对癌症复发恐惧的可行性与初步疗效：一项随机对照试点研究 Jialing LinZhixuan KangFeifei Huang Research 27 February 2026 Article: 198 Unveiling disparities in lung cancer care: a joint spatio-temporal analysis of multidisciplinary meeting presentation, supportive care screening, and diagnostic timeliness in Victoria 揭示肺癌诊疗差异：维多利亚州多学科会诊展示、支持性护理筛查及诊断及时性的联合时空分析 Getayeneh Antehunegn TesemaRob G. StirlingArul Earnest Research 27 February 2026 Article: 197 Transcriptome-based high-frequency recurrence index predicts frequent recurrence in non-muscle-invasive bladder cancer after Bacillus Calmette-Guérin therapy 基于转录组的高频复发指数可预测卡介苗治疗后非肌层浸润性膀胱癌的频繁复发情况 Seung-Woo BaekYoung Joon ByunSeok Joong Yun Research 27 February 2026 Article: 196 Life-course influence of birthweight and subsequent pathways on healthy aging: a Mendelian randomization study 出生体重对健康老龄化的终身影响及后续途径：一项孟德尔随机化研究 Lijie KongChun DouTiange Wang Research 25 February 2026 Article: 195 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用 Routine inflammatory indices modify clonal hematopoiesis-related prognostic risk in patients undergoing percutaneous coronary intervention: a real-world cohort study 常规炎症指标改变接受经皮冠状动脉介入治疗患者的克隆性造血相关预后风险：一项现实队列研究 Xuxiang ShenYing SongXiangfeng Lu Research 25 February 2026 Article: 194 Health experiences and outcomes of autistic and non-autistic adults with hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorder 自闭症和非自闭症成年孤独症患者及非孤独症患者中患有高迁移率埃勒斯-丹洛斯综合征和高迁移率谱系障碍者的健康体验和预后 Catherine J. CromptonThemis N. EfthimiouKathryn M. Berg Research 25 February 2026 Article: 193 Part of 1 collection:Child and adolescent psychiatry 所属专题合集：儿童与青少年精神病学 Effects of non-pharmacological interventions on sleep quality in older adults: a systematic review and network meta-analysis of randomized controlled trials 非药物干预措施对老年人睡眠质量影响：基于随机对照试验的系统综述和网络荟萃分析 Jia SongHeng DongShangfeng Tang Research 25 February 2026 Article: 192 Cortical excitability mapping stratifies neurobiological subtypes of schizophrenia with genetic and molecular signatures 皮质兴奋性映射对具有遗传和分子特征的精神分裂症神经生物学亚型进行分层 Sixuan GuoYu ZhaoQiyong Gong Research 25 February 2026 Article: 191 Minimum 18-week chemotherapy improves survival in locally advanced rectal cancer after neoadjuvant radiotherapy: a post hoc analysis of the STELLAR trial 新辅助放疗后局部晚期直肠癌患者接受至少18周化疗可改善生存率：STELLAR试验的事后分析 Tongzhen XuHuiying MaJing Jin Research 25 February 2026 Article: 190 Helminth coinfections mitigate clinical, parasitological, and immune outcomes in Mozambican children with malaria 在莫桑比克患疟疾的儿童中，蠕虫共感染可减轻临床、寄生虫学和免疫学转归 Inocência CuambaRebeca SantanoCarlota Dobaño Research 31 March 2026 Article: 189 Effectiveness of group-based art interventions for late-life depression: a systematic review and meta-analysis of randomized controlled trials 团体艺术干预对老年抑郁症的疗效：一项针对随机对照试验的系统综述和荟萃分析 Mohamad AzhdarlooRaziyeh AtaeiAbouzar Nazari Research 24 February 2026 Article: 188 The associations of consultant sex on herding‑like prescribing behaviour: evidence from a web-based experiment with female primary care physicians in England 顾问性别对从众式处方行为的影响：来自一项针对英格兰女性初级保健医生的网络实验的证据 Sandro Tiziano StoffelMatthias SchwenkglenksBerna Cennet Özdemir Research 24 February 2026 Article: 187 Tricarboxylic acid cycle metabolite index predicts adverse outcomes in acute myocardial infarction patients 三羧酸循环代谢物指数预测急性心肌梗死患者的不良预后 Ye WangPengyan WuBo Yu Research 24 February 2026 Article: 186 Targeting cancer stem cells predicts response and reverses chemoresistance in ascites-derived ovarian cancer organoids 靶向癌症干细胞可预测腹水来源的卵巢癌类器官的反应并逆转化疗耐药性 Xiaoli ZhangWen ZhangHuiqin Guo Research 24 February 2026 Article: 185 Neural vulnerability to stress in adolescents: a longitudinal study using polyconnectomic scoring of depression risk 青少年神经对压力的易感性：一项使用抑郁风险多连接组评分进行的纵向研究 Yuan LiuMeijuan LiJie Li Research 24 February 2026 Article: 184 Part of 1 collection:Child and adolescent psychiatry 所属专题合集：儿童与青少年精神病学 Classification of ALS molecular subtypes: a literature review on machine learning applications and their clinical value 肌萎缩侧索硬化症分子亚型分类：机器学习应用及其临床价值的文献综述 John K. JammalEsteban A. GomezAlfredo Iacoangeli Review 23 February 2026 Article: 183 Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates 所属专题合集：肌萎缩侧索硬化症：最新进展与新动态 Can we protect refugee children from mental health problems?— a scoping review of modifiable factors to inform preventive interventions 我们能否保护难民儿童免受心理健康问题困扰？——一项旨在为预防性干预提供信息的可改变因素的范围性综述 Rita GonçalvesM J MarquesSónia Dias Research 23 February 2026 Article: 182 Part of 1 collection:Child and adolescent psychiatry 所属专题合集：儿童与青少年精神病学 The Trial Bank initiative to promote trustworthy living evidence for medication safety (PROMISE) of children: design and pilot validation 促进儿童用药安全可信实时证据（PROMISE）的试验库计划：设计与初步验证 Chang XuSuhail A. DoiPROMISE Collaborative Research Network Research 21 February 2026 Article: 181 Is liquid biopsy a cost-effective method to diagnose Burkitt Lymphoma in children and young adults? A health economic evaluation in Tanzania 液体活检是否为诊断坦桑尼亚儿童和青年成人伯基特淋巴瘤的一种具有成本效益的方法？一项卫生经济学评估 Jingjing JiangLiz MorrellAI-REAL Consortium Research 21 February 2026 Article: 180 The influence of immunohistochemistry-based subtypes on overall survival in breast cancer spine metastases: a systematic review and meta-analysis 基于免疫组织化学的亚型对乳腺癌脊柱转移总生存期的影响：一项系统综述和荟萃分析 Fon-Yih TsuangYun-Heng LiChung Liang Chai Research 21 February 2026 Article: 179 Prenatal exposure to maternal asthma and asthma medication and neurodevelopmental outcomes: a population cohort study of 179,024 children 产前接触母体哮喘及哮喘药物与神经发育结局的关系：一项针对179,024例儿童的人群队列研究 Lama A. ShakhshirSarjit SinghMichael Fleming Research 20 February 2026 Article: 178 First-in-human phase 1/2a study of T3011, an oncolytic HSV expressing IL-12 and PD-1 antibody, administered via intratumoral (IT) injection as monotherapy in advanced solid tumors, including recurrent or metastatic HNSCC T3011（一种表达IL-12和PD-1抗体的溶瘤性单纯疱疹病毒）首次人体1/2a期研究：通过瘤内（IT）注射作为单一疗法治疗包括复发或转移性头颈部鳞状细胞癌在内的晚期实体瘤 Dongmei JiWenmin FuXichun Hu Research 20 February 2026 Article: 177 Expanding access to cerebrovascular imaging with routine MRI for pre-surgical assessment of intracranial tumor patients: an AI model development and multi-center validation study 利用常规MRI扩大脑血管成像在颅内肿瘤患者术前评估中的应用范围：一项人工智能模型开发与多中心验证研究 Chaoyue ChenZhouyang HuangJianguo Xu Research 20 February 2026 Article: 176 Changing landscape of physical fitness and urban–rural inequalities: evidence from 1.2 million children and adolescents over 20 years of urbanization 20年城市化进程中120万例儿童和青少年体质健康状况及城乡差异的变化 Shan CaiJiaxin LiYi Song Research 19 February 2026 Article: 175 Efficacy and safety of anti-prediabetic drugs in patients with prediabetes: a Bayesian network meta-analysis 抗糖尿病前期药物在糖尿病前期患者中的疗效和安全性：一项贝叶斯网状荟萃分析 Yike WuZihan WangGuo Ma Research 19 February 2026 Article: 174 Clonal haematopoiesis of indeterminate potential and risk of incident psychiatric disorders Yuefeng YuChenyi WanNingjian Wang 意义未明的克隆性造血与新发精神障碍风险 Research 18 February 2026 Article: 173 Spatial characterization of intrahepatic fat deposition across steatotic liver disease subcategories: a multicenter study 脂肪性肝病各亚类中肝内脂肪沉积的空间特征：一项多中心研究 Yan-Ci ZhaoMin WangFeng Chen Research 18 February 2026 Article: 172 Pregnancy outcomes among medically complex populations with high risk of pregnancy mortality in Virginia: a retrospective observational study 弗吉尼亚州妊娠死亡高风险医学复杂人群的妊娠结局：一项回顾性观察研究 Michael J. GreenLauren G. AndersonJonas J. Swartz Research 18 February 2026 Article: 171 Maternal amino acid metabolites during pregnancy and preterm birth: results from two prospective cohort studies 孕期母体氨基酸代谢物与早产的关系：两项前瞻性队列研究的结果 Jingnan ChenYidan DongJu-Sheng Zheng Research 18 February 2026 Article: 170 Correction: Trajectory of the body weight after drug discontinuation in the treatment of anti-obesity medications 更正：停用抗肥胖药物后体重的变化轨迹 Han WuWenjia YangLinong Ji Correction 25 March 2026 Article: 169 Physical activity patterns and cardiovascular disease risk in adults with overweight or obesity: a prospective cohort study 超重或肥胖成人身体活动模式与心血管疾病风险：一项前瞻性队列研究 Kai MuYanan QiaoBo Xi Research 16 February 2026 Article: 168 Part of 1 collection:Weight loss interventions and their health impacts 所属专题合集：减肥干预措施及其对健康的影响 Maternal migraine and offspring ADHD: triangulating the evidence 母亲偏头痛与后代多动症（ADHD）：多方证据综合分析 Yaxin LuoChristina DardaniEvie Stergiakouli Research 14 February 2026 Article: 167 Part of 1 collection:Child and adolescent psychiatry 所属专题合集：儿童与青少年精神病学 An autonomous siRNA delivery system targeting NLRP3: implications in Parkinson’s disease 靶向NLRP3的自主性小干扰RNA（siRNA）递送系统：在帕金森病中的潜在意义 Lishan LinZhizong LiZhong Pei Research 12 February 2026 Article: 166 Lay descriptions of painful temporomandibular disorders—an international consensus proposal for Global Burden of Disease estimates 颞下颌关节紊乱病疼痛的通俗描述——全球疾病负担评估的国际共识提案 A. LövgrenP. LivP. Svensson Research 17 March 2026 Article: 165 Association of soluble tumor necrosis factor receptor 1 with tau pathology, brain atrophy, and cognitive decline: a longitudinal study 可溶性肿瘤坏死因子受体1与tau蛋白病变、脑萎缩及认知功能下降的关联：一项纵向研究 Yutong ZhangLulu SunAlzheimer’s Disease Neuroimaging Initiative Research 11 February 2026 Article: 164 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用 Particulate matter and respiratory health in middle-aged and older adults: disentangling size-fractionated and constituent-specific effects under China’s clean-air policies 颗粒物与中老年人呼吸系统健康的关系：厘清中国净化空气政策下不同粒径及成分的特定影响 Yujing ChenZhaoyan LiuYu-ming Chen Research 11 February 2026 Article: 163 Part of 1 collection:Climate change and human health 所属专题合集：气候变化与人类健康 Clinical impact and cost-effectiveness of vaccinating infants and adolescents against invasive meningococcal B disease in the Netherlands 荷兰为婴儿和青少年接种针对侵袭性脑膜炎球菌B病的疫苗的临床影响和成本效益 Thomas OttenMirjam KnolAnneke Steens Research 10 February 2026 Article: 162 Association between trajectories of sleep quality and postpartum depression: a group-based trajectory model and computer-simulated network analysis 睡眠质量轨迹与产后抑郁之间的关联：基于组别的轨迹模型和计算机模拟网络分析 Xiaoxiao MeiJinzhou YuZengjie Ye Research 10 February 2026 Article: 161 Part of 1 collection:Sleep and mental health 所属专题合集：睡眠与心理健康 Understanding Japan’s mortality advantage: a comparison of mortality in independent and dependent older adults in Japan and Sweden 解读日本在死亡率方面的优势：日本与瑞典独立生活及依赖他人生活老年人的死亡率比较 Shunsuke MurataMarcus EbelingKarin Modig Research 23 March 2026 Article: 160 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学及风险因素的作用 The Young Adult Sleep model: an evolving causal loop diagram of mental health dynamics 青年睡眠模型：心理健康动态演变的因果环路图 Jeroen F. UlemanRushd F. M. Al-ShamaNaja Hulvej Rod Research 16 March 2026 Article: 159 Part of 1 collection:Sleep and mental health 所属专题合集：睡眠与心理健康 Oncostatin-M ligand-based CAR-T therapy displays robust anti-tumor activity against osteosarcoma 基于抑瘤素M配体的CAR-T疗法对骨肉瘤显示出强大的抗肿瘤活性 Daniel FeinbergVinayak UppinReshmi Parameswaran Research 17 March 2026 Article: 158 Antimicrobial catheters coated with poly-L-lysine for the prevention of bacteriuria in adults requiring short-term catheterization: a multicenter randomized controlled trial 涂有聚-L-赖氨酸的抗菌导管预防短期导尿成人患者菌尿症：一项多中心随机对照试验 Xinfei LiJun LiuKai Zhang Research 09 February 2026 Article: 157 Penpulimab in combination with lenalidomide and R-GemOx regimen (R2-GemOx-PD1i) in relapsed or refractory diffuse large B-cell lymphoma: a multicenter, single-arm, phase 2 trial 派安普利单抗联合来那度胺和R-GemOx方案（R2-GemOx-PD1i）治疗复发或难治性弥漫性大B细胞淋巴瘤：一项多中心、单臂、2期试验 Jin-Hua LiangTong-Yao XingWei Xu Research 09 February 2026 Article: 156 Digital twin brain reveals state-specific stimulation targets for abnormal brain dynamics in tinnitus 数字孪生大脑揭示耳鸣异常脑动力学状态特异性刺激靶点 Jiaqi ZhangShuting HanTianzi Jiang Research 10 February 2026 Article: 155 The case for mandatory reporting to enable targets for healthy and environmentally sustainable food: means, motive and opportunity 强制报告实现健康且环境可持续食物目标的理由：方法、动机和机会 Rachel PecheyLauren BandySusan A. Jebb Debate 10 February 2026 Article: 154 Genetic insights into radiomic and proteomic changes under β1-blockers treatment in hypertensive heart disease and hypertrophic cardiomyopathy β1受体阻滞剂治疗高血压性心脏病和肥厚型心肌病时放射组学和蛋白质组学变化的遗传学见解 Zhe ChenYifan TangKai Xie Research 09 February 2026 Article: 153 Part of 1 collection:Cardiomyopathy and cardiac arrhythmias 所属专题合集：心肌病与心律失常 Optimizing drug-resistant tuberculosis diagnosis: cost-effectiveness of rapid molecular and phenotypic assays in South Africa 优化耐药结核病诊断：南非快速分子和表型检测方法的成本效益分析 Ginenus FekaduTadesse TolossaWai Kit Ming Research 09 February 2026 Article: 152 Maternal smoking based on pre-birth health examination and risk of neurodevelopmental disorders in offspring: insights from a Korean mother–child cohort 基于产前健康检查探讨母亲吸烟与后代神经发育障碍风险的关系：来自韩国母婴队列研究的见解 Chan Soon ParkMoonyoung JangJun-Bean Park Research 11 March 2026 Article: 151 Part of 1 collection:Child and adolescent psychiatry 所属专题合集：儿童与青少年精神病学 Effects of ablation versus drug therapy on clinical outcomes and quality of life by frailty status in atrial fibrillation: a post hoc analysis of the CABANA trial 根据衰弱状态分析消融术与药物治疗对心房颤动患者临床预后和生活质量的影响：CABANA试验的事后分析 Lili WangYanguang LiYunlong Wang Research 07 February 2026 Article: 150 Part of 1 collection:Cardiomyopathy and cardiac arrhythmias 所属专题合集：心肌病与心律失常 Quantifying lifetime risk for 1,401 infectious diseases across the diabetes spectrum using a Bayesian approach 采用贝叶斯方法量化糖尿病全病程中1401种传染病的终生风险 Boomer B. OlsenMartin Tristani-FirouziEdgar Javier Hernandez Research 07 February 2026 Article: 149 Part of 1 collection:Diabetes and infectious disease 所属专题合集：糖尿病与传染病 Risk assessment of asthma and allergic rhinitis in atopic dermatitis patients treated with biologics and JAK inhibitors: a systematic review and network meta-analysis of randomized controlled trials 对接受生物制剂和JAK抑制剂治疗的特应性皮炎患者罹患哮喘和过敏性鼻炎的风险评估：一项针对随机对照试验的系统综述和网络荟萃分析 Liling ZengTong ZhouJing Li Research 07 February 2026 Article: 148 Preclinical activity of brincidofovir in peripheral T-cell and NK/T-cell lymphoma 布林西多福韦（brincidofovir）在外周T细胞和NK/T细胞淋巴瘤中的临床前活性 Jason Yongsheng ChanElizabeth Chun Yong LeeChoon Kiat Ong Research 06 February 2026 Article: 147 Genetic risk factors modulate the association between physical activity and colorectal cancer 遗传风险因素调节身体活动与结直肠癌之间的关联 Anita R. PeoplesMireia Obón-SantacanaVictor Moreno Research 05 February 2026 Article: 146 A neuroimaging biomarker for disease staging in clinically diagnosed Alzheimer’s disease 临床诊断阿尔茨海默病的疾病分期神经影像学标志物 Zhuangzhuang LiShaozhen YanYong Liu Research 05 February 2026 Article: 145 Association of GLP-1 receptor agonists with herpes risks in diabetes mellitus: a target trial emulation 胰高血糖素样肽-1（GLP-1）受体激动剂与糖尿病中疱疹风险的关联：一项目标试验模拟研究 Chi-Hsien HuangI-Hui ChiangJames Cheng-Chung Wei Research 31 December 2025 Article: 144 Part of 1 collection:Diabetes and infectious disease 所属专题合集：糖尿病与感染性疾病 Neoadjuvant immunochemotherapy plus thymalfasin in locally advanced gastric cancer: a prospective clinical trial 局部晚期胃癌联合胸腺肽的新辅助免疫化疗：一项前瞻性临床试验 Hao XuFengyuan LiZekuan Xu Research 26 February 2026 Article: 143 Part of 1 collection:Clinical trials for gastrointestinal cancer 所属专题合集：胃肠道癌症的临床试验 Detection of sequelae from acute meningitis during clinical review by a healthcare provider: a systematic review and meta-analysis 临床医生在临床复查中检测急性脑膜炎后遗症：一项系统综述和荟萃分析 Luisa F. AlvizCarla Y. KimKiran T. Thakur Research 28 February 2026 Article: 142 Part of 1 collection:Acute meningitis: a collection of systematic reviews 所属专题合集：急性脑膜炎：系统综述合集 ISG15-driven immune modulation and tumor progression in breast cancer metastasis: insights from single-cell and spatial transcriptomics ISG15驱动的免疫调节与乳腺癌转移中的肿瘤进展：来自单细胞和空间转录组学的见解 Hua ShaoHanlu TangYongqing Xu Research 04 February 2026 Article: 141 Evaluating the impact of family history and polygenic risk scores on cardiometabolic disease risk 评估家族史和多基因风险评分对心代谢疾病风险的影响 Ebuka OnyenobiKnightess OyiboSally N. Adebamowo Research 03 February 2026 Article: 140 Social networking site use, depressive and anxiety symptoms in adolescents: evidence from a longitudinal cohort study (SCAMP) 社交网站使用与青少年抑郁和焦虑症状：来自纵向队列研究（SCAMP）的证据 Chen ShenBraulio M. Girela-SerranoMireille B. Toledano Research 03 February 2026 Article: 139 Part of 1 collection:Child and adolescent psychiatry 所属专题合集：儿童与青少年精神病学 Early gestational prediction of spontaneous preterm birth using a validated three-protein serum biomarker panel 使用经验证的三蛋白血清生物标志物组合进行早孕期自发性早产预测 Qiong LuoJuan WeiXuefeng B. Ling Research 02 February 2026 Article: 138 Household cannabis cessation and adolescent mental health outcomes in a prospective cohort study 一项前瞻性队列研究中家庭大麻戒断与青少年心理健康预后的关系 Ming WangYixiang XuFei Li Research 02 February 2026 Article: 137 Part of 1 collection: Psychoactives: Recreational drugs repurposed as novel therapies 所属专题合集：精神活性物质：娱乐性药物重新利用为新型疗法 Objective assessment of long-term impact of COVID-19 on multiple sensory functions 客观评估新冠肺炎对多种感觉功能的长期影响 Ahmad OdehVeronica L. FormanekKai Zhao Research 27 February 2026 Article: 136 Detection of hearing loss by formal audiological testing after acute infectious meningitis: a global systematic review and meta-analysis 急性感染性脑膜炎后通过正式听力检测诊断听力损失：一项全球系统综述和荟萃分析 Luisa F. AlvizCarla Y. KimKiran T. Thakur Review 28 February 2026 Article: 135 Part of 1 collection: Acute meningitis: a collection of systematic reviews 所属专题合集：急性脑膜炎：系统综述合集 Serological evidence of substantial respiratory syncytial virus infection burden among older adults residing in Swedish long-term care facilities 血清学证据表明，居住在瑞典长期护理机构中的老年人存在沉重的呼吸道合胞病毒感染负担 Preeti MoarChristoffer GranvikMattias N. E. Forsell Research 24 February 2026 Article: 134 Association of parental education with offspring psychiatric diagnoses, violent crimes, and suicidal behavior: a nationwide Swedish quasi-experimental study 父母受教育程度与后代精神疾病诊断、暴力犯罪和自杀行为之间的关联：一项瑞典全国范围的准实验研究 Mengping ZhouHenrik LarssonErik Pettersson Research 26 February 2026 Article: 133 Discriminative performance of externally validated dementia risk prediction models: a systematic review and meta-analysis 外部验证的痴呆风险预测模型的鉴别性能：一项系统综述和荟萃分析 Blossom C. M. StephanJacob BrainMario Siervo Research 02 February 2026 Article: 132 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用 Efficacy and safety of intravenous administration of high-dose selenium for preventing chemotherapy-induced peripheral neuropathy in platinum-sensitive recurrent ovarian cancer: a phase 3, double-blind, parallel group, randomized controlled pilot study 静脉注射大剂量硒预防铂敏感复发性卵巢癌化疗所致周围神经病变的有效性和安全性：一项3期、双盲、平行组、随机对照试点研究 Ga Won YimKyung Hee HanHee Seung Kim Research 02 February 2026 Article: 131 Time for change in implementation research and practice 实施研究和实践中变革的时机已到 Mike EnglishJacob McKnightSebastian Fuller Debate 02 February 2026 Article: 130 CardioMetAge estimates cardiometabolic aging and predicts disease outcomes CardioMetAge可评估心脏代谢年龄并预测疾病结局 Yucan LiXinming XuKelin Xu Research 31 January 2026 Article: 129 Disproportionate climate burden of rising temperatures on low birth weight in Pakistan 气温上升给巴基斯坦低出生体重儿带来的不成比例的气候负担 Syeda H. FatimaCorey J. A. BradshawZohra S. Lassi Research 31 January 2026 Article: 128 Part of 1 collection: Climate change and human health 所属专题：气候变化与人类健康 Enhancing oncolytic virotherapy with a tri-specific T-cell engager targeting CD3ε, EpCaM, and 4-1BB: preclinical evaluation and implications for cancer immunotherapy 利用靶向CD3ε、EpCaM和4-1BB的三特异性T细胞衔接器增强溶瘤病毒疗法：临床前评估及对癌症免疫疗法的启示 Zhongyi DongHaoyu ZhangZizhen Zhang Research 30 January 2026 Article: 127 Targeting BCL-XL for degradation synergizes with gemcitabine against cholangiocarcinoma 靶向降解BCL-XL与吉西他滨联用对胆管癌具有协同治疗作用 Qinghua ZengYan ZhangYonghan He Research 30 January 2026 Article: 126 Association of DNA methylation with hypertension and blood pressure: a 7-year longitudinal study from KORA F4/FF4 DNA甲基化与高血压及血压的关联：来自KORA F4/FF4的7年纵向研究 Liye LaiAngelina Shin Yee JongMelanie Waldenberger Research 04 February 2026 Article: 125 Shared genetic architecture of psychoactive substance use and pan-cancer: insights from a large‑scale genome‑wide cross‑trait analysis 精神活性物质使用与泛癌症的共享遗传结构：来自大规模全基因组跨性状分析的见解 Jiahang SongPengzhu LiOlivier Gires Research 05 February 2026 Article: 124 Part of 1 collection: Psychoactives: Recreational drugs repurposed as novel therapies 所属专题：精神活性物质：作为新型疗法的娱乐性药物再利用 Intrauterine exposure to maternal diabetes and the risk of developing epilepsy in children: a national cohort study of 2.3 million children 宫内暴露于母体糖尿病与儿童患癫痫风险的关系：一项针对230万儿童的全国队列研究 Muhammad Zakir HossinMartina PerssonNeda Razaz Research 14 February 2026 Article: 123 ADHD and adherence to antihypertensive medication treatment: a multinational cohort study 多动症与坚持抗高血压药物治疗的关系：一项多国队列研究 Honghui YaoYiling ZhouZheng Chang Research 20 February 2026 Article: 122 How effective is rejoining a long-term weight loss program? The 5- and 10-year MRI-assessed Follow Interventions Trial (FIT) project 重新加入长期减肥计划的效果如何？5年和10年磁共振成像评估的随访干预试验（FIT）项目 Hadar KleinDafna PachterIris Shai Research 30 January 2026 Article: 121 Part of 1 collection: Weight loss interventions and their health impacts 所属专题：减肥干预措施及其对健康的影响 Correction: Brain state dynamics and working memory in patients with schizophrenia and unaffected siblings 更正：精神分裂症患者及其未受影响兄弟姐妹的脑状态动态与工作记忆 Feiwen WangJie YangLena Palaniyappan Correction 20 February 2026 Article: 120 Ocular light and optical radiation exposure as a modifiable environmental determinant of health: expert consensus on research gaps and priorities 作为可改变的环境健康决定因素的眼睛光暴露和光学辐射暴露：关于研究空白和优先事项的专家共识 Manuel SpitschanAnna M. BillerJohannes Zauner Guideline 29 January 2026 Article: 119 Dietary patterns and neuropsychological function in adolescents: a cross-sectional and longitudinal study 青少年饮食模式与神经心理功能：一项横断面和纵向研究 Alexios ManidisNicolas Ayala-AldanaJordi Julvez Research 29 January 2026 Article: 118 Part of 1 collection: Child and adolescent psychiatry 所属专题：儿童与青少年精神病学 Factors impacting the delivery of contextualized care in serious illness: a focus group study with healthcare professionals 影响危重症患者情境化护理实施的因素：一项针对医疗保健专业人员的焦点小组研究 Linda ModderkolkYvonne SchoonAnne B. Wichmann Research 29 January 2026 Article: 117 Part of 1 collection: Palliative care and medicine 所属专题：姑息治疗与医学 Early interventions for first onset of symptoms of mental health conditions: an umbrella review of systematic reviews 针对心理健康问题首次出现症状的早期干预措施：一项系统综述的伞式评价 Jasmine LeePhoebe BarnettSonia Johnson Research 29 January 2026 Article: 116 Harmonic patterns embedded in ictal EEG signals in focal epilepsy: new insight into the epileptogenic zone 局灶性癫痫发作间期脑电图信号中嵌入的谐波模式：对致痫区的新见解 Lingli HuLingqi YeShuang Wang Research 28 January 2026 Article: 115 Part of 1 collection: Epilepsy: Seizure prevention, treatment, and epidemiology 所属专题合集：癫痫：发作预防、治疗和流行病学 Effects of aerobic or resistance exercise on sleep and cancer-related fatigue in patients with breast cancer during or after neoadjuvant chemotherapy: a 3-arm randomized controlled trial 有氧运动或抗阻运动对新辅助化疗期间或之后乳腺癌患者睡眠和癌症相关疲劳的影响：一项三臂随机对照试验 Alexander HaussmannMartina E. SchmidtKaren Steindorf Research 28 January 2026 Article: 114 Neutrophil methylmalonic acid promotes microthrombus formation and adverse cardiac remodeling post-myocardial infarction through activating IL-6 signaling pathway-mediated NETosis 中性粒细胞甲基丙二酸通过激活IL-6信号通路介导的中性粒细胞胞外诱捕网形成（NETosis），促进心肌梗死后微血栓形成和不良心脏重构 Yige LiuJiaxin WangShaohong Fang Research 28 January 2026 Article: 113 Statistical approaches to analyse the combined effect of seven air pollutants and breast cancer risk: a case–control study nested in the French E3N-Generations cohort 分析七种空气污染物联合作用与乳腺癌风险关系的统计方法：一项嵌套于法国E3N-Generations队列的病例对照研究 Camille GiampiccoloBéatrice FerversAmina Amadou Research 28 January 2026 Article: 112 Part of 1 collection: Carcinogens and human health 所属专题合集：致癌物与人类健康 Is behaviour change communication guidance for general practice healthcare professionals evidence based? A systematic review 针对全科医疗保健专业人员的行为改变沟通指导是否具有循证依据？一项系统综述 Anika Schwarze-ChintapatlaJonathan Livingstone-BanksCharlotte Albury Research 16 February 2026 Article: 111 Patient-centred postpartum care provision: virtual delivery, tiered escalation, and tensions between efficiency, preference, and clinical concern 以患者为中心的产后护理服务提供：虚拟服务模式、分级转诊机制，以及效率、患者偏好与临床关切之间的矛盾 Sergio A. SilverioJulia R. B. BrownEmma L. Duncan Research 24 February 2026 Article: 110 Ethical dilemmas in climate change and healthcare delivery: a cross-sectional survey of US patient perspectives 气候变化与医疗服务中的伦理困境：一项针对美国患者观点的横断面调查 Andrew HantelEmily SenayGregory A. Abel Research 27 January 2026 Article: 109 Part of 1 collection: Climate change and human health 所属专题：气候变化与人类健康 Inetetamab plus camrelizumab and utidelone for pretreated HER2-positive advanced breast cancer: a prospective, single-arm, phase 2 study 伊尼妥单抗联合卡瑞利珠单抗和优替德隆治疗既往接受过治疗的HER2阳性晚期乳腺癌：一项前瞻性、单臂、2期研究 Huimin LvTao SunMin Yan Research 27 January 2026 Article: 108 Potential of earlier primary care health checks for prevention of cardiovascular events in younger age groups: population-based study in the United Kingdom 早期初级保健健康检查对预防年轻人群心血管事件的潜力：英国一项基于人群的研究 Catherine A. ScottLinxin LiPeter M. Rothwell Research 24 January 2026 Article: 107 Comparative effects of salt substitutes on blood pressure, cardiovascular events and mortality: a systematic review and network meta-analysis 盐替代品对血压、心血管事件和死亡率影响的比较：一项系统综述和网络荟萃分析 Honghao LaiGihad NesrallahBradley C. Johnston Research 23 January 2026 Article: 106 Association of short-term exposure to ambient air pollutants with liver function and mediation by fasting insulin: evidence from a rural cohort in China 短期暴露于环境空气污染物与肝功能的关系及空腹胰岛素的中介作用：来自中国农村队列研究的证据 Mengxin WangAogang ZhangWeidong Wu Research 23 January 2026 Article: 105 Part of 1 collection:Climate change and human health 所属专题：气候变化与人类健康 Adjuvant tislelizumab, lenvatinib, and capecitabine for resected biliary tract cancer: a prospective phase II trial 辅助治疗：替雷利珠单抗、仑伐替尼和卡培他滨用于可切除的胆道癌：一项前瞻性II期试验 Yun FengNing ZhangLu Wang Research 23 January 2026 Article: 104 Comparative effectiveness of sleeve gastrectomy and semaglutide for weight loss and metabolic outcomes: a prospective non-randomized study 袖状胃切除术与司美格鲁肽对减重及代谢结局的疗效比较：一项前瞻性非随机研究 Yutung YenQian ZhangYi Chen Research 22 January 2026 Article: 103 Part of 1 collection:Weight loss interventions and their health impacts 所属专题：减重干预措施及其对健康的影响 Impact of sex on outcomes in patients treated with drug-coated balloons versus drug-eluting stents for de novo coronary artery lesions: Insights from the REC-CAGEFREE I trial 性别对接受药物涂层球囊与药物洗脱支架治疗的新发冠状动脉病变患者预后的影响：来自REC-CAGEFREE I试验的见解 Ping WangJingyu ZhouLing Tao Research 22 January 2026 Article: 102 Assessing the comorbidity between asthma and depression through polygenic risk scoring and time-to-event models 通过多基因风险评分和时间事件模型评估哮喘与抑郁的共病情况 Xueting WangJun HeRenato Polimanti Research 22 January 2026 Article: 101 Persistent immune, coagulation and cardiac dysregulation are correlated with later post-discharge mortality in children with severe malnutrition 严重营养不良儿童出院后持续存在的免疫、凝血和心脏功能失调与后期死亡率相关 Brenda KamauEvans O. MudiboJames M. Njunge Research 22 January 2026 Article: 100 Correction: Computer assisted verbal autopsy: comparing large language models to physicians for assigning causes to 6939 deaths in Sierra Leone from 2019–2022 更正：计算机辅助口头尸检：对比大型语言模型与医生为2019 - 2022年塞拉利昂6939例死亡分配病因的情况 Richard WenAnteneh Tesfaye AssalifRashid Ansumana Correction 14 February 2026 Article: 99 Characteristics of parks associated with depression in women only: a cross-sectional study of 329,363 adults 仅与女性抑郁相关的公园特征：一项针对329,363名成年人的横断面研究 Jonathan R. OlsenNatalie NichollsRichard Mitchell Research 21 January 2026 Article: 98 Weight change mediates the effect of lifestyle intervention on postpartum diabetes in women with prior gestational diabetes: a secondary analysis of a randomized clinical trial 在生活方式干预对既往妊娠期糖尿病女性产后糖尿病影响中，体重变化的中介作用：一项随机临床试验的二次分析 Weiqin LiHuikun LiuGang Hu Research 21 January 2026 Article: 97 Part of 1 collection: Diagnosis and management of gestational diabetes 所属专题：妊娠期糖尿病的诊断与治疗 Global drivers of heart failure attributable to atrial fibrillation/flutter: insights fromJoinpoint regression, age-period-cohort analysis, and future projections from the GBD 2021 Study 心房颤动/扑动所致心力衰竭的全球驱动因素：来自折点回归、年龄-时期-队列分析以及2021年GBD（全球疾病负担）研究未来预测的见解 Jing ChenZhu LiGregory Y. H. Lip Research 20 January 2026 Article: 96 Part of 1 collection: Cardiomyopathy and cardiac arrhythmias 所属专题：心肌病与心律失常 Overdiagnosis of gestational diabetes mellitus during Ramadan: a retrospective population-based study in Catalonia, Spain 斋月期间妊娠期糖尿病的过度诊断：西班牙加泰罗尼亚地区一项基于人群的回顾性研究 Marta CarrascoBogdan VlachoMarta Hernández Research 20 January 2026 Article: 95 Part of 1 collection: Diagnosis and management of gestational diabetes 所属专题：妊娠期糖尿病的诊断与管理 Why current risk factor-based approaches fall short in predicting stillbirth: a national cohort study of nulliparous women in England 为何当前基于风险因素的方法在预测死胎方面存在不足：英格兰初产妇全国队列研究 A. HowellB. ThilaganathanTommy’s National Centre for Maternity Improvement Research 22 January 2026 Article: 94 Pay-it-forward intervention increased pneumococcal vaccine uptake among older adults in China: a randomized controlled trial 爱心传递干预措施提高了中国老年人肺炎球菌疫苗的接种率：一项随机对照试验 Jiao QinChunxing TaoBingyu Liang Research 19 January 2026 Article: 93 The impact of e-cigarette taxation: a systematic review and meta-analysis on usage, pricing strategies, and public health implications 电子烟税收的影响：针对使用情况、定价策略和公共卫生影响开展的系统综述和荟萃分析 Quan WangZheng ZhuLi Yang Research 17 January 2026 Article: 92 Safety and preliminary efficacy results of IBI389, an anti-Claudin18.2×CD3 bispecific antibody, in patients with solid tumors and gastric or gastro-esophageal tumors: a phase 1 dose escalation and expansion study 抗Claudin18.2×CD3双特异性抗体IBI389在实体瘤及胃或胃食管肿瘤患者中的安全性与初步疗效结果：一项1期剂量递增与扩展研究 Xiaoyu LiRuihong DaiFeng Bi Research 16 January 2026 Article: 91 Part of 1 collection: Clinical trials for gastrointestinal cancer 所属专题：胃肠道癌症临床试验 Comparative risk of delirium among opioid users for non-cancer pain: a retrospective cohort study 比较非癌症疼痛使用阿片类药物者发生谵妄的风险：一项回顾性队列研究 Carlos Raul Ramirez MedinaMark LuntMeghna Jani Research 31 January 2026 Article: 90 Association between preoperative interruption of antiplatelet therapy and postoperative thrombotic risk after minimally invasive surgery for abdominopelvic cancer in patients treated with P2Y12 inhibitors 接受P2Y12抑制剂治疗的患者行腹部盆腔癌症微创手术时，术前中断抗血小板治疗与术后血栓形成风险之间的关联 Masashi KubotaSatomi YoshidaKoji Kawakami Research 16 January 2026 Article: 89 Comparative outcomes of distal ureterectomy vs. radical nephroureterectomy in high-risk distal ureteral urothelial carcinoma: a two-center cohort study in Northern and Southern China 高危远端输尿管尿路上皮癌患者行远端输尿管切除术与根治性肾输尿管切除术的疗效比较：中国北方和南方两家中心的队列研究 Junyi XieZhenhua LiuWei Yu Research 16 January 2026 Article: 88 Co-occurrence patterns and related risk factors of dementia and Parkinson’s disease among older adults across 204 countries and territories: a spatial correspondence and systematic analysis 204个国家和地区老年人痴呆症与帕金森病共现模式及相关危险因素：空间对应与系统分析 Weiyang ChenMin DuJue Liu Research 15 January 2026 Article: 87 Accelerated brain aging in amyotrophic lateral sclerosis and its prognostic associations: a cohort study 肌萎缩侧索硬化症加速脑衰老及其预后关联：一项队列研究 Chenhao FangJiaoting JinShuoqiu Gan Research 15 January 2026 Article: 86 Part of 1 collection: Amyotrophic lateral sclerosis: latest advances and novel updates 所属专题：肌萎缩侧索硬化症：最新进展与新动态 The clinical effects and cortical mechanism of rTMS in poststroke lateropulsion: a randomized controlled trial 重复经颅磁刺激（rTMS）对脑卒中后侧方倾倒的临床效果及皮质机制：一项随机对照试验 Lijiao MengRaymond C. C. TsangQuan Wei Research 14 January 2026 Article: 85 5-HT2C receptors in the glutamatergic neurons of dorsal raphe nucleus orchestrate the comorbidity of pain and anxiety in mice 中脑背侧缝际核谷氨酸能神经元中的5-HT2C受体调控小鼠疼痛与焦虑共病 Qi ZhangLi XieRiyue Jiang Research 13 January 2026 Article: 84 The clinical landscape of POLE-mutant colorectal cancer: a retrospective analysis of real-world outcome POLE突变型结直肠癌的临床现状：一项现实结局的回顾性分析 Ting XuXuhui ZhangJian Li Research 13 January 2026 Article: 83 The efficacy and safety of duloxetine in treating refractory chronic cough: a randomized clinical trial 度洛西汀治疗难治性慢性咳嗽的有效性和安全性：一项随机临床试验 Shengyuan WangHeng WuXianghuai Xu Research 13 January 2026 Article: 82 Impact of diagnosis to ablation time on clinical outcomes in patients with atrial fibrillation: post hoc analysis of the CABANA trial 心房颤动患者从诊断到消融的时间对临床预后的影响：CABANA试验的事后分析 Manlin ZhaoYang ChenGregory Y. H. Lip Research 12 January 2026 Article: 81 Part of 1 collection: Cardiomyopathy and cardiac arrhythmias 所属专题：心肌病与心律失常 Elevated maternal pre-transfer serum lipid peroxidation is associated with implantation failure and early pregnancy loss 母体转运前血清脂质过氧化水平升高与着床失败和早期流产相关 Zhangwei JiaJunxiang RenJunhao Yan Research 12 January 2026 Article: 80 Impact of Helicobacter pylori infection on gut and intratumoral microbiome and its association with immunotherapy response in gastrointestinal cancer 幽门螺杆菌感染对肠道和肿瘤内微生物组的影响及其与胃肠道癌症免疫治疗反应的关联 Keren JiaYang ChenLin Shen Research 12 January 2026 Article: 79 Part of 1 collection: Gut microbiota: New treatments of human disease 所属专题：肠道微生物组：人类疾病的新疗法 SGLT-2 Inhibitor use and liver-related and mortality outcomes in patients with type 2 diabetes and compensated cirrhosis SGLT-2抑制剂在2型糖尿病合并代偿性肝硬化患者中的应用及其对肝脏相关预后和死亡率的影响 Tien-Shin ChouDaniel Hsiang-Te TsaiEdward Chia-Cheng Lai Research 12 January 2026 Article: 78 Extrapolating from trials to clinic: a predictive model defining the boundaries of benefit for multiple sclerosis therapies in real-world populations based on systematic review 从试验外推至临床：基于系统综述构建预测模型，界定多发性硬化症疗法在现实人群中的获益边界 Bibiana BielekovaTianxia WuMichael Calcagni Research 10 January 2026 Article: 77 A validated model for early prediction of group A streptococcal aetiology in necrotising soft tissue infections using minimal patient data 利用最少患者数据早期预测坏死性软组织感染A组链球菌病因的验证模型 Sonja KatzJaco SuijkerEdoardo Saccenti Research 10 January 2026 Article: 76 Trends in lipid-lowering therapies in acute coronary syndromes after Chinese new insurance policy: a real-world analysis 中国新医保政策实施后急性冠状动脉综合征患者降脂治疗趋势：一项现实情况分析 Xin ZhaoShujing WuJunbo Ge Research 09 January 2026 Article: 75 Fragmented healthcare and effective maternal coverage in Mexico, 2009–2023 2009-2023年墨西哥医疗体系碎片化与有效孕产妇医疗保障 Edson Serván-MoriDiego Cerecero-GarcíaOctavio Gómez-Dantés Research 09 January 2026 Article: 74 Circadian rhythm disruption in cardiovascular disease: a systematic review and meta-analysis of mechanistic evidence from animal models 昼夜节律紊乱与心血管疾病：基于动物模型机制证据的系统综述与荟萃分析 Mrinal K. DasEvi De RyckJohanna Samulin Erdem Research 09 January 2026 Article: 73 Frailty progression: The role of multimorbidity configurations in frailty transitions and predicting mortality risk among older adults 衰弱进展：多重共病组合模式在老年人衰弱状态转变及死亡风险预测中的作用 Rafael Ogaz-GonzálezQian ZouEva Corpeleijn Research 08 January 2026 Article: 72 Part of 1 collection: Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题：健康老龄化与长寿：预防医学及风险因素的作用 Effect of probiotic supplementation on the gut microbiota diversity in healthy populations: a systematic review and meta-analysis of randomised controlled trials 益生菌补充剂对健康人群肠道微生物群多样性的影响：一项针对随机对照试验的系统综述和荟萃分析 Anna Júlia ÉliásKincső Csepke Földvári-NagyLászló Földvári-Nagy Research 07 January 2026 Article: 71 Part of 1 collection: Gut microbiota: New treatments of human disease 所属专题：肠道微生物群：人类疾病的新疗法 Pain and high-impact pain in community-dwelling older adults in Australia and relation to sociodemographic and health-related factors, including physical disability, psychological distress, and quality of life 澳大利亚社区居住老年人的疼痛及重度疼痛情况，及其与社会人口统计学因素和健康相关因素（包括身体残疾、心理困扰和生活质量）的关系 Grace JoshySaman Khalatbari-SoltaniEmily Banks Research 22 January 2026 Article: 70 Mortality and morbidity burden associated with smoking: evidence from a 1.6 million cohort in Hong Kong 与吸烟相关的死亡率和发病率负担：来自香港160万人队列研究的证据 Boyuan WangTingting ChenEric Yuk Fai Wan Research 06 January 2026 Article: 69 Part of 1 collection:Carcinogens and human health 所属专题：致癌物与人类健康 Association between long-term extreme high temperature and mortality: a 9-million prospective cohort study 长期极端高温与死亡率之间的关系：一项900万人的前瞻性队列研究 Bo YinQi HuangKuiying Gu Research 06 January 2026 Article: 68 Part of 1 collection:Climate change and human health 所属专题：气候变化与人类健康 Unraveling the neurotoxic mechanisms of tranexamic acid in epilepsy induction: a network toxicology and molecular docking approach 利用网络毒理学和分子对接方法揭示氨甲环酸诱发癫痫的神经毒性机制 Tianyang ChenDalong LiuXiangYang Leng Research 03 January 2026 Article: 67 Part of 1 collection: Epilepsy: Seizure prevention, treatment, and epidemiology 所属专题：癫痫：癫痫发作的预防、治疗和流行病学 Trop2 immuno-PET/CT imaging of prostate cancer: a proof-of-concept translational study Trop2免疫正电子发射断层扫描/计算机断层扫描（PET/CT）成像在前列腺癌中的应用：一项概念验证性转化研究 Xingru LongShuxian AnDawei Jiang Research 31 December 2025 Article: 66 Methylmalonate accumulation contributes to myocardial vulnerability post-reperfusion: a novel therapeutic target and prognostic biomarker 甲基丙二酸蓄积促进再灌注后心肌脆弱性：一种新型治疗靶点和预后生物标志物 Shanjie WangJunChen GuoShaohong Fang Research 31 December 2025 Article: 65 Prophylactic effect of intraoperative sodium oxybate on postoperative delirium in older patients undergoing major orthopedic surgery: a randomized clinical trial 术中羟丁酸钠对接受大型骨科手术的老年患者术后谵妄的预防作用：一项随机临床试验 Meiying CuiHang XuePing Zhao Research 31 December 2025 Article: 64 Part of 1 collection:Psychoactives: Recreational drugs repurposed as novel therapies 所属专题：精神活性物质：将娱乐性药物重新用于新型疗法 Prevalence of hysterectomy in urban China and associations between metabolic disorders and hysterectomy: a multicenter population-based study involving over 9 million women 中国城市子宫切除术的流行情况以及代谢紊乱与子宫切除术之间的关系：一项涉及超过900万女性的多中心人群基础研究 Yanrui BiYuan MaYing Gao Research 30 December 2025 Article: 63 Sex differences in cardiac risk and kidney function: serum creatinine versus cystatin C 心脏风险和肾功能方面的性别差异：血清肌酐与胱抑素C的对比 Nicole L. De La MataJames A. HedleyJennifer S. Lees Research 30 December 2025 Article: 62 The association of post-conization pregnancy with subsequent cervical lesions: evidence from a nationwide cohort in Sweden 锥切术后妊娠与后续宫颈病变的关联：来自瑞典全国队列研究的证据 Huan YiJimiao HuangJianguang Ji Research 29 December 2025 Article: 61 Tibial periosteal distraction for ischemic leg ulcers: animal and clinical cohort study 胫骨骨膜牵张术治疗缺血性下肢溃疡：动物及临床队列研究 Peilin ZhouWenqiang WangQikai Hua Research 28 December 2025 Article: 60 Preoperative conversion therapy of camrelizumab combined with paclitaxel and nedaplatin for unresectable advanced esophageal squamous cell carcinoma: a phase 2 study 卡瑞利珠单抗联合紫杉醇和奈达铂对不可切除的晚期食管鳞癌的术前转化治疗：一项2期研究 Jinhong ZhuJinfeng ZhangJianqun Ma Research 28 December 2025 Article: 59 Clustering of cardiometabolic risk factors, physical activity, digital exclusion, and depressive symptoms trajectories in adults aged 50years and older: findings from two prospective cohort studies 50岁及以上成年人心血管代谢风险因素聚集、身体活动、数字排斥及抑郁症状轨迹：两项前瞻性队列研究的发现 Xiaosheng DongJiaqiang XiaoChengchao Zhou Research 28 December 2025 Article: 58 Eligibility of real-world patients for aspirin primary prevention trials in cardiovascular disease 现实中符合心血管疾病阿司匹林一级预防试验资格的患者情况 Michael HolderDaniel R. MoralesBruce Guthrie Research 27 January 2026 Article: 57 Polygenic risk score-guided personalized osteoporosis screening: a population-based study 基于多基因风险评分指导的个性化骨质疏松症筛查：一项基于人群的研究 Dongxue WangWen SunJianguang Ji Research 14 January 2026 Article: 56 Urea cycle modulation by combined SGLT2 inhibitors and metformin SGLT2抑制剂与二甲双胍联合用药对尿素循环的调节作用 Makoto HaradaJonathan AdamRui Wang-Sattler Research 08 January 2026 Article: 55 Safety and neuroprotective efficacy of the VCP inhibitor ML240 in large-animal and human retinal explants: a preclinical ex vivo study VCP抑制剂ML240在大型动物及人视网膜外植体中的安全性和神经保护功效：一项临床前离体研究 Ana-Cristina Almansa-GarcíaAngela ArmentoBlanca Arango-Gonzalez Research 10 January 2026 Article: 54 Impact of an eight-week isocaloric vegan dietary intervention on hemogram parameters and lymphocyte subsets: a randomized-controlled trial 为期八周的等热量纯素饮食干预对血细胞参数和淋巴细胞亚群的影响：一项随机对照试验 Julian HerterFrieda StübingMaximilian Andreas Storz Research 10 January 2026 Article: 53 Association between psychosocial factors and adverse effects of light-to-moderate ambient heat in patients with chronic diseases: results of the prospective cohort study CLIMATE-II 社会心理因素与轻至中度环境热对慢性病患者不良影响之间的关联：前瞻性队列研究CLIMATE-II的结果 Ingmar SchäferValentina PauckeDagmar Lühmann Research 15 January 2026 Article: 52 Part of 1 collection:Climate change and human health 所属专题：气候变化与人类健康 Maternal infection during pregnancy and the risk of childhood cancer: a systematic review and meta-analysis 孕期母体感染与儿童期患癌风险：一项系统综述和荟萃分析 Loviisa MulanjeLara Kim BrackmannRajini Nagrani Research 14 January 2026 Article: 51 Part of 1 collection:Carcinogens and human health 所属专题：致癌物与人类健康 Supplementary biomarker testing in molecular tumor boards increases actionable therapy recommendations: a prospective real-world study of 658 patients 分子肿瘤委员会中的补充生物标志物检测增加了可采取治疗措施的建议：一项针对658例患者的前瞻性真实世界研究 Alexander ScheiterSimon MellinKirsten Utpatel Research 14 January 2026 Article: 50 Computer assisted verbal autopsy: comparing large language models to physicians for assigning causes to 6939 deaths in Sierra Leone from 2019–2022 计算机辅助口头尸检：对比大型语言模型与医生对塞拉利昂2019 - 2022年6939例死亡原因的判定 Richard WenAnteneh Tesfaye AssalifRashid Ansumana Research 24 December 2025 Article: 49 Loss of Y chromosome and its implications in male amyotrophic lateral sclerosis: insights from the UK Biobank Y染色体缺失及其在男性肌萎缩侧索硬化症中的影响：来自英国生物银行的研究见解 Wei-Ming SuQing-Qing DuanYong-Ping Chen Research 24 December 2025 Article: 48 Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates 所属专题：肌萎缩侧索硬化症：最新进展与新动态 Prenatal lipopolysaccharide exposure programs the early-life lung development by modulating mesenchymal fibroblasts in a time- and dose-dependent manner 产前脂多糖暴露通过调节间充质成纤维细胞以时间和剂量依赖性方式来影响早期肺部发育 Ying DongStefan HadzicSaverio Bellusci Research 22 December 2025 Article: 47 Life course socioeconomic trajectories and chronic disease risk in later life among 30,055 older adults across 27 European countries (the SHARE study) 27个欧洲国家30,055名老年人生命历程中的社会经济轨迹与晚年慢性疾病风险（基于SHARE研究） Taymara C. AbreuJoline W. J. BeulensJoreintje D. Mackenbach Research 20 December 2025 Article: 46 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题：健康老龄化与长寿：预防医学与风险因素的作用 Validation of a novel patient-reported measure of the burden of digital care in diabetes 由糖尿病患者报告的数字化护理负担新型测评工具的验证 Misk Al ZahidyJennifer L. RidgewayVictor M. Montori Research 20 December 2025 Article: 45 Determinants of long-term SARS-CoV-2 immune responses in asymptomatic-to-moderate COVID-19 patients in sub-Saharan Africa 撒哈拉以南非洲地区无症状至中度 COVID-19 患者长期 SARS-CoV-2 免疫应答的决定因素 Víctor L. de RiojaOdin GoovaertsGemma Moncunill Research 14 January 2026 Article: 44 Camrelizumab and apatinib in Chinese patients with locally advanced or metastatic radioiodine-refractory differentiated thyroid cancer: an exploratory open-label, single-arm trial 卡瑞利珠单抗联合阿帕替尼治疗中国局灶性晚期或转移性放射性碘难治性分化型甲状腺癌：一项探索性开放标签单臂试验 Xin ZhangDi SunYansong Lin Research 18 December 2025 Article: 43 Urinary polyphenol signature of the Mediterranean diet is associated with lower cardiovascular disease risk: the PREDIMED trial 地中海饮食的尿液多酚特征与心血管疾病风险较低相关：PREDIMED 试验 Inés Domínguez-LópezPolina GalkinaRosa M. Lamuela-Raventós Research 18 December 2025 Article: 42 Meta-analysis and external validation of a risk model for gastrointestinal bleeding after percutaneous coronary intervention 经皮冠状动脉介入治疗后胃肠道出血风险模型的荟萃分析及外部验证 Hualong MaCong PengQiaohong Yang Research 18 December 2025 Article: 41 DNA methylation-based clocks, tobacco smoking, and lung cancer risk 基于DNA甲基化的生物钟、烟草吸烟与肺癌风险 Ricardo Cortez Cardoso PenhaJustina Ucheojor OnwukaMattias Johansson Research 17 December 2025 Article: 40 Part of 1 collection:Carcinogens and human health 所属专题：致癌物与人类健康 Risk and protective factors associated with brain grey matter patterns in a population-based cohort of cognitively unimpaired 70years old 认知功能未受损的70岁老年人基于人口的队列中，与大脑灰质模式相关的风险和保护因素 Giulia LorenzonAnna MarsegliaEric Westman Research 17 December 2025 Article: 39 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题：健康老龄化与长寿：预防医学和风险因素的作用 Street view-derived city built environment and vulnerability to temperature extremes: a nationally representative population-based cohort study 基于街景图像的城市建成环境与极端温度脆弱性：一项全国代表性人口队列研究 Wanzhou WangChao YangLuxia Zhang Research 16 December 2025 Article: 38 Part of 1 collection:Climate change and human health 所属专题：气候变化与人类健康 A booster dose of an inactivated SARS-CoV-2 vaccine targeting virus variants sustains protective humoral and cellular immunity 针对病毒变异株的灭活严重急性呼吸系统综合征冠状病毒2（SARS-CoV-2）疫苗加强针可维持保护性体液免疫和细胞免疫 Constanza MéndezLinmar Rodríguez-GuilarteSusan M. Bueno Research 15 December 2025 Article: 37 Dapagliflozin alleviates sunitinib-induced cardiotoxicity through AMPKα-PPARα axis and enhances the sensitivity of renal cell carcinoma to sunitinib 达格列净通过AMPKα-PPARα轴减轻舒尼替尼诱导的心脏毒性，并增强肾细胞癌对舒尼替尼的敏感性 Shi-yu HuangMin HuLei Wang Research 15 December 2025 Article: 36 Network dysfunction underlying verbal fluency deficits in newly diagnosed epilepsy: a resting-state fMRI functional connectivity study 新诊断癫痫患者言语流畅性缺陷背后的网络功能障碍：一项静息态功能磁共振成像功能连接研究 Fangzhou LiuPing JiangLing Liu Research 13 December 2025 Article: 35 Part of 1 collection:Epilepsy: Seizure prevention, treatment, and epidemiology 所属专题：癫痫：癫痫发作的预防、治疗和流行病学 Long-term quality of life in non-epithelial ovarian cancer survivors: TMRG-GINECO-Vivrovaire rare tumors case–control study 基于广西新生儿地中海贫血基因组图谱计划开展的家庭三联体/四联体分析 Coraline DubotIsabelle Ray-CoquardFlorence Joly Research 12 December 2025 Article: 34 Family trios/quartets analysis based on the Newborn Genomic Atlas for Thalassemia project in Guangxi 非上皮性卵巢癌幸存者的长期生活质量：TMRG-GINECO-Vivrovaire罕见肿瘤病例对照研究 Wei WeiChunrong GuiBaoheng Gui Research 12 December 2025 Article: 33 Hyperuricemic persons use more analgesics than normouricemic—is asymptomatic hyperuricemia really asymptomatic? 高尿酸血症患者比血尿酸正常者使用更多镇痛药——无症状性高尿酸血症真的“无症状”吗？ Janis TimsansJenni Emilia KauppiMarkku Kauppi Research 11 December 2025 Article: 32 Social isolation, loneliness, and multi-system medical conditions: phenome-wide association and disease-trajectory analyses 社会孤立、孤独感与多系统医学病症：全表型组关联分析及疾病轨迹研究 Tingshan DuanZhi CaoChenjie Xu Research 10 December 2025 Article: 31 Digital marketing techniques within online food retail platforms: a scoping review 在线食品零售平台中的数字营销技巧：一项范围综述 Adyya GuptaCatherine E. HugginsAnna Peeters Research 10 December 2025 Article: 30 Dramatic increases in redundant publications in the Generative AI era 生成式人工智能时代冗余出版物数量急剧增加 Danny MaupinTulsi SuchakMatt Spick Research 09 December 2025 Article: 29 Cardiovascular risk burden and guideline-recommended lipid and blood pressure goals in an Italian Cohort: findings from the HUMTELEMED web-based platform 意大利人群心血管风险负担及指南推荐的血脂和血压目标达成情况：HUMTELEMED网络平台的发现 Matteo LandolfoAlessandro GezziRiccardo Sarzani Research 09 December 2025 Article: 28 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题：健康老龄化与长寿：预防医学及风险因素的作用 Efficacy and safety of Janus kinase 1/2 inhibitor KL130008 in active rheumatoid arthritis: a randomized, double-blind, placebo-controlled phase II trial Janus激酶1/2抑制剂KL130008治疗活动性类风湿关节炎的有效性和安全性：一项随机、双盲、安慰剂对照的II期试验 Yue ChengHonghu TangYi Liu Research 09 December 2025 Article: 27 Risk stratification for endometrial cancer: independent and joint effects of polygenic risk score and body mass index in 129,829 UK Biobank participants 子宫内膜癌的风险分层：英国生物银行129,829名参与者中多基因风险评分和体重指数的独立及联合效应 Xuemin WangLaure DossusTracy A. O’Mara Research 10 February 2026 Article: 26 Maternal probiotics intake during pregnancy and exclusive colostrum breastfeeding are associated with a reduced risk of neonatal jaundice 孕期摄入益生菌及纯母乳喂养初乳与新生儿黄疸风险降低相关 Bekalu Kassie AlemuChi Chiu WangYao Wang Research 08 December 2025 Article: 25 Hepatic steatosis in postmenopausal women is characterized by distinct serum extracellular vesicle proteomic signatures 绝经后女性脂肪肝具有独特的血清细胞外囊泡蛋白质组特征 Patrick PirrotteBrooke LovellJohanna K. DiStefano Research 07 December 2025 Article: 24 Global, regional, and national temporal trends in the prevalence of environmental heat and cold exposure among older adults aged 60–99 years, 1990–2021: an age-period-cohort analysis based on the Global Burden of Disease Study 2021 基于2021年全球疾病负担研究，对1990 - 2021年60 - 99岁老年人环境热暴露和冷暴露患病率的全球、区域和国家时间趋势分析：一项基于年龄 - 时期 - 队列模型的分析 Shenghao XuJing WangJianlin Xiao Research 07 December 2025 Article: 23 Part of 1 collection:Climate change and human health 所属专题：气候变化与人类健康 Cyclophilin B deficiency enhances myocardial energy synthesis and protects against heart failure in preclinical models 亲环蛋白B缺乏可增强心肌能量合成，并在临床前模型中预防心力衰竭 Xiao ZongXierenayi TudiRong Tao Research 07 December 2025 Article: 22 Part of 1 collection:Cardiomyopathy and cardiac arrhythmias 所属专题：心肌病与心律失常 Normobaric hyperoxia for intracerebral hemorrhage: a randomized clinical trial 常压高氧治疗脑出血：一项随机临床试验 Zhiying ChenJiayue DingRan Meng Research 07 December 2025 Article: 21 Nationwide trends in pediatric hospitalizations for eating disorders in France between 2013 and 2022: a retrospective study using the national health insurance database Emmanuelle LogeaisFrançoise TroussierLilia Khendek 2013 - 2022年法国因进食障碍住院的儿科患者全国趋势：一项使用国家健康保险数据库的回顾性研究 Research 05 December 2025 Article: 20 Part of 1 collection:Child and adolescent psychiatry 所属专题：儿童与青少年精神病学 Self-management of vaginal pessaries for pelvic organ prolapse: multi-method process evaluation, linked to the TOPSY randomised controlled trial 盆腔器官脱垂阴道子宫托自我管理：与TOPSY随机对照试验相关的多方法过程评估 Carol BuggeMelanie Dembinskythe TOPSY team Research 05 December 2025 Article: 19 Large-scale plasma proteomics reveals bidirectional associations between sleep patterns and inflammatory bowel disease: a prospective cohort study 大规模血浆蛋白质组学研究揭示睡眠模式与炎症性肠病之间的双向关联：一项前瞻性队列研究 Kaixing LeYaru LiuZhigang Liu Research 05 December 2025 Article: 18 Association between socioeconomic status and diabetic retinopathy in individuals with type 1 diabetes: a systematic review and meta-analysis 1型糖尿病患者社会经济地位与糖尿病视网膜病变之间的关联：一项系统综述和荟萃分析 Fernando Sebastian-VallesSergio Núñez de Arenas-ArroyoJulia Martínez-Alfonso Review 05 December 2025 Article: 17 Patterns of disparity: age and socioeconomic differences in women’s smoking and quitting outcomes in Great Britain 差异模式：英国女性吸烟及戒烟结局的年龄和社会经济差异 Sarah E. JacksonCaitlin NotleySharon Cox Research 10 February 2026 Article: 16 Genomic pathogenic alterations in the SWI/SNF complex compromise the outcomes of immunotherapy in Chinese patients with KRAS-mutant NSCLC by downregulating STING expression SWI/SNF复合体中的基因组致病性改变通过下调STING表达损害中国KRAS突变型非小细胞肺癌患者的免疫治疗效果 Lingling GaoJie JiangXuchao Zhang Research 03 December 2025 Article: 15 Residential radon exposure and incident myocardial infarction and stroke risks in the All of Us Research Program “我们所有人”研究项目中住宅氡暴露与心肌梗死和卒中发病风险的关系 Jiajun LuoZhihao JinBriseis Aschebrook-Kilfoy Research 03 December 2025 Article: 14 Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet and cardiovascular disease and arrhythmias 用于延缓神经退行性变的地中海饮食-终止高血压膳食疗法干预措施（MIND）与心血管疾病及心律失常的关系 Pei QinFrederick K. HoJill P. Pell Research02 December 2025 Article: 13 Part of 1 collection: Cardiomyopathy and cardiac arrhythmias 所属专题：心肌病与心律失常 KoMethylNet: a novel epigenetic clock based on neural network analysis of DNA methylation data and epigenetic age acceleration in a Korean population KoMethylNet：基于神经网络分析DNA甲基化数据的新型表观遗传时钟及韩国人群的表观遗传年龄加速研究 Dabin YunKwangyeon OhNan Song Research 03 December 2025 Article: 12 Part of 1 collection: Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题：健康老龄化与长寿：预防医学及风险因素的作用 Sleep and physical activity trade-offs and dementia risk: a prospective cohort study in UK Biobank participants 睡眠与体力活动的权衡与痴呆风险：英国生物样本库参与者的一项前瞻性队列研究 Stephanie YiallourouLachlan CribbMatthew P. Pase Research 03 December 2025 Article: 11 Part of 1 collection: Sleep and mental health 所属专题：睡眠与心理健康 Integration of gut microbiome and lipid metabolism reveals the anti-cancer effects of pentadecanoic acid on bladder cancer 肠道微生物组与脂质代谢的整合揭示十五烷酸对膀胱癌的抗癌作用 Ya-Ting ChenJing SuiEvan Yi-Wen Yu Research 03 December 2025 Article: 10 Part of 1 collection: Gut microbiota: New treatments of human disease 所属专题：肠道微生物群：人类疾病的新疗法 A social determinants-based county-level cardiovascular mortality index to identify high-risk counties in the USA 基于社会决定因素的美国县级心血管疾病死亡率指数，用于识别高风险县 Anqi ZhuBibhas ChakrabortyTazeen H. Jafar Research 02 December 2025 Article: 9 HIV infection and immunosenescence: challenges and intervention strategies HIV感染与免疫衰老：挑战与干预策略 Junyan JinQianqian XuBin Su Review 02 December 2025 Article: 8 Part of 1 collection: Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题：健康老龄化与长寿：预防医学与风险因素的作用 Machine learning-based prediction of short-term outcomes in aneurysmal subarachnoid hemorrhage: a multicenter study integrating clinical and inflammatory indicators 基于机器学习的动脉瘤性蛛网膜下腔出血短期预后预测：一项整合临床与炎症指标的多中心研究 Weichong ZhouCong PengHui Shi Research 29 November 2025 Article: 7 The effectiveness and safety of a mobile application-based self-regulation intervention to support weight loss among adults living with obesity: a large-scale pragmatic randomised controlled trial 基于移动应用程序的自我调节干预措施在支持肥胖成年人减重方面的有效性与安全性：一项大规模实用性随机对照试验 Paul DoodyGina M. WrenPaul Aveyard Research 29 November 2025 Article: 6 Part of 1 collection: Weight loss interventions and their health impacts 所属专题：减重干预措施及其对健康的影响 Adiposity and the first-onset of diagnosed mental illnesses: a population-based cohort study of 10 million UK adults 脂肪堆积（肥胖程度）与首次确诊精神疾病的关系：一项基于1000万英国成年人的队列研究 Xue DongPaul AveyardMin Gao Research 29 November 2025 Article: 5 Efficacy of standard care versus acoustic therapy on acute tinnitus in idiopathic sudden sensorineural hearing loss: a randomized controlled trial 标准治疗与声治疗对特发性突发性感音神经性听力损失伴急性耳鸣的疗效对比：一项随机对照试验 Xinyi WangKe QiuYu Zhao Research 28 November 2025 Article: 4 Trends and socio-economic inequalities in overweight- and obesity-related premature cardiovascular disease mortality in Australia 澳大利亚超重与肥胖相关过早心血管疾病死亡的趋势及社会经济不平等状况 Tim Adair Research 29 January 2026 Article: 3 Assessing the impact of maternal blood pressure during pregnancy on perinatal health: a wide-angled Mendelian randomization study 评估孕期母体血压对围产期健康的影响：一项广角孟德尔随机化研究 Fernanda Morales-BersteinAna Gonçalves-SoaresMaria-Carolina Borges Research 14 January 2026 Article: 2 Part of 1 collection:Diagnosis and management of gestational diabetes 所属专题：妊娠期糖尿病的诊断与管理 Prevalence of use and interest in using glucagon-like peptide-1 receptor agonists for weight loss: a population study in Great Britain 胰高血糖素样肽-1受体激动剂用于减重的使用率及使用意愿：一项针对英国人群的研究 Sarah E. JacksonJamie BrownLion Shahab Research 08 January 2026 Article: 1 Part of 1 collection: Weight loss interventions and their health impacts 所属专题：减重干预措施及其对健康的影响

2026-07-20

·终身学习-星辰如梦

【药品分享】塞普替尼胶囊——全球首款高选择性RET靶向药 || 国内唯一拥有12岁以上儿童甲状腺肿瘤完整临床证据的RET抑制剂

塞普替尼胶囊为礼来研发的全球首款高选择性RET靶向药，2020年率先在美国FDA上市，2022年 9月经国内优先审评获批上市，同步覆盖RET融合肺癌、RET突变甲状腺髓样癌、碘难治RET融合甲状腺癌三大适应症（含 12 岁以上青少年人群），目前术后辅助治疗新适应症正在优先审评阶段，国内各级医院全面铺货，为CSCO指南Ⅰ级一线推荐用药。基本信息规格：40mg、80mg胶囊作用机制：高选择性抑制RET激酶，阻断RET融合/突变驱动的肿瘤增殖信号，相比多激酶抑制剂脱靶副作用更小，对脑转移病灶颅内缓解率突出。国内获批适应症（需基因检测确证RET变异）：成人RET融合阳性局部晚期/转移性非小细胞肺癌（NSCLC）； RET突变型晚期/转移性甲状腺髓样癌（MTC）：成人及12岁以上需全身治疗儿童；放射性碘难治RET融合阳性晚期甲状腺癌：成人及12岁以上需全身治疗儿童。用法用量（成人/12 岁+青少年） 1. 体重分层剂量体重＜50kg：120mg，每日2次（间隔约12h）；体重≥50kg：160mg，每日2次；持续服用至疾病进展或不可耐受毒性。 2. 服用规则整粒温水吞服，严禁压碎、掰开、咀嚼；普通情况空腹/随餐均可；漏服：距下次服药＞6小时才补服，不足6小时跳过；服药后呕吐不追加剂量。 3. 关键药物相互作用调整抑酸药（PPI奥美拉唑/雷贝拉唑等）：必须随餐服用塞普替尼； H2受体拮抗剂（法莫替丁）：错开2h前/10h后服药；强效CYP3A抑制剂（伊曲康唑、克拉霉素）：需减量；CYP3A诱导剂（利福平）禁止联用。常见不良反应（发生率≥25%）实验室异常：转氨酶（AST/ALT）升高、血糖升高、白细胞/血小板减少、低钙、低钠、肌酐升高、高胆固醇。临床症状：口干、腹泻、便秘、高血压、疲乏、外周水肿、皮疹、恶心、头痛、QT间期延长、出血倾向。严重警告与监测肝毒性：51%患者AST升高、45% ALT升高，3/4级肝损伤约8%-9%。监测：用药前查肝功，前3个月每2周一次，之后每月复查；转氨酶显著升高需暂停、减量或永久停药。高血压：35%出现高血压，17%为3级；用药前控制好血压，服药1周后监测血压，常规每月复查。 QT间期延长：可致QTc显著延长，有猝死风险；基线+定期查心电图、血钾/镁/钙，低电解质需提前纠正。出血风险：可发生颅内出血、咯血等致死性出血；重度出血永久停药。过敏反应：用药1-2周易发：发热、皮疹、关节痛伴血小板 / 转氨酶下降；需激素治疗，复发则永久停药。其他高危提示：肿瘤溶解综合征（甲状腺髓样癌高负荷患者）：提前补液预防。手术：择期术前停药≥7天；大手术后至少2周再恢复，避免伤口愈合不良；胚胎毒性：育龄男女服药+停药后1周严格避孕；孕期禁用、停药哺乳。临床优势对比（vs 普拉替尼）唯一拥有甲状腺髓样癌III期完整临床数据，NCCN/CSCO更高等级推荐；肺癌脑转移颅内缓解率更高，2年颅内进展风险仅0.7%； ≥3级不良反应、治疗中断/永久停药发生率更低；国内唯一有12岁以上儿童甲状腺癌临床实证的 RET 靶向药。塞普替尼 vs 普拉替尼（均为高选择性RET抑制剂，需基因检测确证RET融合/突变后方可使用）上市情况美国：塞普替尼胶囊（睿妥®）原研为礼来，是全球首款高选择性RET激酶抑制剂。2020年5月获美国FDA首批（商品名Retevmo），海外陆续拓展适应症，现已获批2岁以上RET变异不限癌种实体瘤，同步覆盖肺癌、甲状腺肿瘤全线后线、一线及辅助治疗场景，在欧美多国纳入医保，为NCCN指南RET靶点优先推荐药物。中国： 2021年11月：CDE受理上市申请，纳入优先审评； 2022年9月30日：NMPA附条件批准上市（化学5.1类创新药），商品名睿妥®。获批适应症：成人RET融合阳性局部晚期/转移性非小细胞肺癌；成人及12岁以上青少年RET突变晚期甲状腺髓样癌；成人及12岁以上青少年放射性碘难治RET融合晚期甲状腺癌。临床市场地位：上市后纳入2024版CSCO非小细胞肺癌指南Ⅰ级一线推荐，针对 RET 阳性肺癌脑转移颅内缓解优势突出，是国内唯一拥有12岁以上儿童甲状腺肿瘤完整临床证据的RET抑制剂。注册与受理信息 2026年7月17日：IB-IIIA期RET融合非小细胞肺癌术后辅助治疗新适应症申报，CDE纳入优先审评。临床试验信息专利情况原研Loxo Oncology（后被礼来收购），国内全部专利权属归礼来制药。国内核心化合物专利预估2037-10-10到期；晶型、制剂、中间体专利普遍延后至2038年后到期。 1 核心化合物专利 2 中间体合成与制备工艺专利关键中间体合成路线专利药用盐、晶型 + 制剂专利 3 适应症/新用途治疗方法专利其他药品分享链接如下，欢迎点击查看： Ormeloxifene OTF慢性体重管理的新型药物-Tirzepatide新型的非阿片类小分子镇痛药-Suzetrigine奥麦利昔芬口腔薄膜立项调研报告纳米技术双氯芬酸乳胶剂药学研究2025年9月药品批准信息快讯（八）——利斯的明透皮贴剂分享2025年9月药品批准信息快讯（九）——米托坦片分享CDE-《化学仿制药参比制剂目录（第一百批）》（征求意见稿）[附: 药品分享——阿达苏(洛沙平吸入剂)]药品分享-塞来昔布盐酸曲马多片药品分享——伐莫洛龙口服混悬液【药品分享】盐酸菲优拉生片【药品分享】拉坦噻吗滴眼液【药品分享】Baxdrostat 片【药品分享】Omecamtiv Mecarbil缓释片【药品分享】曲地匹坦（Rolapitant）【药品分享】Zasocitinib 胶囊【药品分享】甲磺酸阿帕替尼片【药品分享】巴氯芬口服溶液【药品分享】奥德昔巴特胶囊【药品分享】扎维吉泮鼻喷雾剂【药品分享】左羟丙哌嗪糖浆【药品分享】利丙双卡因凝胶贴膏【药品分享】司来吉兰改良型新药（缓释片）【药品分享】复方甘菊利多卡因凝胶【药品分享】盐酸索安非托片【药品分享】地塞米松口溶膜【药品分享】盐酸来罗西利片【药品分享】马来酸噻吗洛尔凝胶【药品分享】褪黑素颗粒【药品分享】罗氟司特乳膏【药品分享】盐酸芬戈莫德胶囊【药品分享】示踪用盐酸米托蒽醌注射液【药品分享】美洛昔康纳米晶注射液【药品分享】Clascoterone 5%外用溶液【药品分享】马来酸依那普利口服溶液【药品分享】注射用双氯芬酸钠利多卡因【药品分享】马来酸依那普利叶酸片—复方降压药【药品分享】依曲帕米鼻喷雾剂—用于治疗成人阵发性室上性心动过速的可自行给药鼻喷雾剂【药品分享】奥卡西平口服混悬液—一款可用于儿童的钠通道调节类抗癫痫药【药品分享】泊沙康唑口服混悬液——一种常用的抗真菌药物【药品分享】舒沃替尼片【药品分享】依伏卡塞片——第二代口服拟钙剂【药品分享】西诺氨酯片——第三代抗癫痫发作药物【药品分享】匹妥布替尼片——非共价可逆 BTK 抑制剂（用于复发 / 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NS5A抑制剂【药品分享】克拉考特酮乳膏——外用、非甾体、选择性雄激素受体（AR）抑制剂【药品分享】非卢替尼片——全球首个用于多发性硬化的口服BTK抑制剂【药品分享】Brenipatide注射液——GLP-1R/GIPR双受体激动剂（继替尔泊肽之后的第二款）【药品分享】罗赛促红素α注射液——国产首个长效重组促红细胞生成素（EPO）创新药【药品分享】贝组替凡片——全球首个口服小分子HIF-2α抑制剂【药品分享】那米司特片——口服选择性PDE4B抑制剂【药品分享】富马酸立康可泮胶囊——一款针对罕见病PNH的口服补体B因子抑制剂【药品分享】醋酸索乐匹尼布片——高选择性脾酪氨酸激酶（Syk）抑制剂【药品分享】甲磺酸艾多替尼片——全球首款专为肺癌脑转移设计的第三代EGFR-TKI 【药品分享】安瑞克芬注射液——全球首个获批镇痛适应症的高选择性外周κ-阿片受体（KOR）激动剂【药品分享】Difelikefalin注射液——全球首个获批的外周选择性κ-阿片受体（KOR）激动剂【药品分享】Obefazimod——口服、靶向 CBC、特异性增强miR-124的首创小分子【药品分享】拉尼兰诺片——口服泛PPAR激动剂【药品分享】舒洛地特注射液——抗血栓药、血管保护剂【药品分享】贝普若韦生注射液——反义寡核苷酸（ASO）类乙肝新药【药品分享】氨酚右敏口服溶液（奥肯能®）——中国内地唯一获批的氨酚右敏口服溶液【药品分享】佩玛贝特片——新型过氧化物酶体增殖物激活受体α/δ双重激动剂 (PPARα/δ) 【药品分享】盐酸依匹斯汀乳膏——外用第二代非镇静抗组胺抗过敏药膏【药品分享】注射用双羟萘酸帕瑞肽微球——一款用于治疗肢端肥大症的第二代长效生长抑素类似物（SRL）微球制剂【药品分享】埃拉菲布拉诺片——治疗原发性胆汁性胆管炎（PBC）的口服靶向新药【药品分享】泽卢克布仑钠注射液——新一代皮下注射型C5补体抑制剂【药品分享】依达拉奉右莰醇注射用浓溶液——一款复方神经保护类注射剂【药品分享】醋酸戈那瑞林注射液——促性腺激素释放激素（GnRH）类药物【药品分享】甲磺酸贝舒地尔片——全球首个选择性ROCK2激酶抑制剂【药品分享】伊托法替布软膏——外用JAK抑制剂（JAK1/JAK3）【药品分享】注射用华卟啉钠——新型肿瘤光动力治疗（PDT）专用光敏剂【药品分享】优替德隆胶囊——口服埃博霉素类微管抑制剂【药品分享】艾普美妥司他片——EZH1/2双靶创新药【药品分享】精氨酸艾曲莫德片——新型选择性鞘氨醇1-磷酸受体（S1P₁）调节剂【药品分享】磷酸芦可替尼乳膏——全球/国内首款、唯一获批用于非节段型白癜风复色的外用JAK1/JAK2选择性抑制剂【药品分享】盐酸右哌甲酯缓释胶囊——治疗6岁及以上注意缺陷多动障碍（ADHD）的一线药物【药品分享】抗菌肽PL-3301口腔凝胶——中国首创的抗菌肽类抗口腔真菌感染药物【药品分享】Zasocitinib (TAK-279) 胶囊——新一代高选择性口服 TYK2 抑制剂【药品分享】注射用Abelacimab——一款全人源IgG1单克隆抗体，靶向凝血因子XI（FXI）【药品分享】Duvakitug注射液——首创性人源化IgG1-λ2单克隆抗体，靶向TL1A（TNFSF15）【药品分享】醋酸氟轻松/氢醌/维A酸乳膏——治疗中重度黄褐斑疗效明确的外用复方【药品分享】富马酸伏诺拉生氯化钠注射液——钾离子竞争性酸阻滞剂（P‑CAB）||东阳光药业研发的2.2,2.4类改良新型新药【药品分享】盐酸阿曲生坦片——诺华研发的高选择性内皮素 A（ETA）受体拮抗剂||中国首个获批用于IgA 肾病的非免疫性口服靶向药【药品分享】RGT-274-CR胶囊——上海齐鲁锐格医药研发的口服小分子GLP-1受体激动剂【药品分享】酒石酸西尼必利片——高选择性5-HT₄受体激动剂类胃肠动力药【药品分享】石杉碱甲控释片——采用双相控释/渗透泵技术的2.2类改良型新药【药品分享】塞伐艾替尼片——口服、可逆、选择性酪氨酸激酶抑制剂（TKI）【药品分享】Admilparant片——口服小分子LPA₁受体拮抗剂【药品分享】瑞拉可兰胶囊——全球首个选择性糖皮质激素受体（GR）拮抗剂【药品分享】盐酸依特卡肽注射液——全球首个、国内唯一获批的静脉注射型拟钙剂【药品分享】Avacincaptad pegol玻璃体内注射液——全球首批用于AMD继发地图样萎缩（GA）的靶向药物【药品分享】盐酸达利雷生片——新一代非管制、非苯二氮䓬类抗失眠药物【药品分享】甲磺酸瑞索利塞片——高选择性PI3Kα小分子靶向抑制剂 || 全球首个获批用于特定卵巢癌的靶向新药【药品分享】富马酸西他沙星注射液——新型喹诺酮类抗菌药物【药品分享】Icotrokinra——全球首个获批的口服 IL-23 受体（IL-23R）选择性拮抗多肽【药品分享】氘可来昔替尼片（Deucravacitinib）——全球首个口服、选择性 TYK2 变构抑制剂【药品分享】柯美奇拜单抗注射液——鼻用糖皮质激素治疗后症状控制不佳的成人中重度季节性过敏性鼻炎患者的福音【药品分享】吉诺昔替尼——口服小分子JAK1/TYK2双重抑制剂【药品分享】洛替拉纳（Lotilaner）——GABA 门控氯离子通道非竞争性拮抗剂 || 兼具兽医驱虫与人用眼科两大用途【药品分享】CagriSema——由卡格列肽（cagrilintide）2.4 mg与司美格鲁肽（semaglutide）2.4 mg组成的强效减重复方药【药品分享】苹果酸卡博替尼——口服、多靶点酪氨酸激酶抑制剂（TKI）【药品分享】迪高替尼（Delgocitinib）——一款外用泛JAK抑制剂【药品分享】拉氟莫司(Laflunimus)——口服免疫抑制剂 || 兼具免疫抑制与抗炎双重活性【药品分享】伏昔尼布片——全球首个IDH1/IDH2双重突变抑制剂靶向药【药品分享】盐酸奥昔布宁片——M受体抗胆碱药【药品分享】贝泽昔替尼片——国内首款获批的高选择性JAK2单靶点抑制剂【药品分享】苯甲酸安达艾替尼胶囊——新型小分子酪氨酸激酶不可逆抑制剂（EGFR-TKI）【药品分享】伏欣奇拜单抗注射液——全人源抗IL‑1β单克隆抗体 || 用于急性痛风性关节炎的1类创新生物药【药品分享】利多卡因丁卡因乳膏【药品分享】伐米奇拜单抗注射液——玻璃体内注射用抗IL-6人源化单抗【药品分享】依赛弗酶α注射液（Efzimfotase alfa 注射液）——第二代重组组织非特异性碱性磷酸酶（TNSALP）酶替代疗法【药品分享】格达托利西布（Gedatolisib）——first‑in-class 泛 PI3K/mTORC1/2 双重抑制剂【药品分享】伯瑞替尼肠溶胶囊——中国原研、高选择性c-MET小分子抑制剂 || 首个获批MET扩增NSCLC单药治疗的靶向药【药品分享】力胜克拉片——中国首个申报上市的原研Bcl-2抑制剂、全球第二款Bcl-2抑制剂【药品分享】BGM0504注射液——GLP-1/GIP 双受体激动剂【药品分享】塞利尼索片——全球首个口服选择性核输出蛋白XPO1抑制剂【药品分享】Seltorexant薄膜包衣片——选择性食欲素2受体（OX2R）高选择性拮抗剂【药品分享】盐酸埃克替尼片——国内首个自主研发的一代EGFR-TKI 【药品分享】盐酸伊普可泮胶囊——全球首个口服补体B因子抑制剂【药品分享】恩考芬尼胶囊——靶向BRAF V600突变的口服激酶抑制剂【药品分享】Enpatoran——口服、选择性TLR7/8小分子抑制剂【药品分享】硝酸异康唑阴道片——抗真菌外用药物【药品分享】Zorevunersen注射液——全球独家ASO上调蛋白表达技术【药品分享】妥拉美替尼胶囊——全球首个针对NRAS突变黑色素瘤的MEK抑制剂【药品分享】盐酸替那帕诺片——全球首创NHE3抑制剂类新型降磷药物【药品分享】注射用莱古比星——新型蒽环类抗肿瘤药【药品分享】优替德隆胶囊——口服埃博霉素类微管抑制剂【药品分享】伊那利塞片——中国首个PIK3CA突变乳腺癌精准靶向药【药品分享】呋喹替尼胶囊——中国首个自主研发VEGFR-TKI || VEGFR靶点靶向抗癌药【药品分享】琥珀酸瑞波西利片——CDK4/6抑制剂【药品分享】盐酸替那帕诺片——全球首个且唯一获批的肠道磷吸收抑制剂【药品分享】芬布替尼片——口服、可逆、可透过血脑屏障的BTK抑制剂【药品分享】炔丙基半胱氨酸胶囊——全球首个进入临床的硫化氢（H₂S）供体I类创新药【药品分享】Balcinrenone达格列净胶囊——选择性盐皮质激素受体拮抗剂（MRA）+SGLT-2抑制剂【药品分享】诺拉西班（Nolasiban）分散片——选择性口服催产素受体拮抗剂 || 早产二线/辅助治疗药物【药品分享】塞多明基注射液——国内首款裸质粒基因治疗药物【药品分享】鲁兹诺雷钠片——国产首个高选择性URAT1抑制剂【药品分享】玛伐凯泰胶囊——全球首创、中国唯一获批的心肌肌球蛋白抑制剂【药品分享】依托芬那酯凝胶——外用非甾体抗炎镇痛药【药品分享】聚卡波非钙片——国际指南首选容积性缓泻剂【药品分享】Mezigdomide胶囊——新一代IMiDs/cereblon E3泛素连接酶调节【药品分享】洛布替尼片——全球首款共价+非共价双机制第四代 BTK 靶向药【药品分享】奥莱泊肽注射液——PEG修饰长效GLP‑1单靶点激动剂【药品分享】安瑞曲替尼胶囊 ——国内第二款国产二代NTRK广谱抗癌药【药品分享】麦格司他胶囊——抑制葡萄糖神经酰胺合成酶的罕见病口服靶向药【药品分享】乌帕替尼片（Upadacitinib）——选择性JAK1抑制剂【药品分享】Dordaviprone胶囊——全球首款、目前唯一获批用于 H3 K27M 突变型弥漫性中线胶质瘤（DMG）的靶向药【药品分享】屈昔多巴胶囊——去甲肾上腺素前体药物 || 帕金森、多系统萎缩、神经源性体位低血压一线对症用药【药品分享】康特替尼颗粒——第二代ALK多靶点激酶抑制剂【药品分享】盐酸兰诺可泮片——国产首个获批上市的补体因子B（CFB）抑制剂【药品分享】Elinzanetant软胶囊——全球首款NK1/NK3双重神经激肽受体拮抗剂【药品分享】Fosmanogepix注射液——全球首创（First-in-class）Gwt1抑制剂类抗真菌前药【药品分享】Zorevunersen注射液——反义寡核苷酸药物【药品分享】宗艾替尼片——高选择性不可逆HER2（ERBB2）酪氨酸激酶抑制剂（TKI）【药品分享】甲苯磺酸他拉唑帕利胶囊——高选择性PARP抑制剂【药品分享】Bexicaserin口服溶液——选择性5-HT2C受体激动剂口服液体制剂【药品分享】醋酸伏诺拉生注射用浓溶液——钾离子竞争性酸阻滞剂（P-CAB）【药品分享】甲苯磺酸依仑司群片——新一代口服选择性雌激素受体降解剂（SERD）【药品分享】硫酸瑞美吉泮口崩片——CGRP 受体拮抗剂（降钙素基因相关肽）|| 偏头痛靶向特效药【药品分享】阿托吉泮片——全球首款口服长效CGRP靶点预防偏头痛药物【药品分享】乌布吉泮片——CGRP受体拮抗剂 || 第二代口服偏头痛急性期药物【药品分享】扎维吉泮鼻喷雾剂——高选择性CGRP受体拮抗剂 || 全球唯一获批鼻喷CGRP吉泮类急性期药物【药品分享】培来加南喷雾剂——全球首款上市加南类多肽抗菌药（FIC）【药品分享】艾沙利酮片——高选择性非甾体醛固酮受体拮抗剂（MRA） || 全球首个上市的非甾体选择性MR拮抗剂【药品分享】布美他尼鼻喷雾剂——全球首款、唯一鼻内给药袢利尿剂【药品分享】注射用盐酸依拉环素——新型全合成氟环素类（四环素衍生物）静脉抗生素【药品分享】舒瑞基奥仑赛注射液——全球首款实体瘤自体CLDN18.2靶向CAR-T细胞新药【药品分享】盐酸环喷托酯滴眼液——儿童验光首选短效睫状肌麻痹剂之一【药品分享】盐酸赛庚啶口服溶液——抗过敏抗组胺药【药品分享】Rinzimetostat (ORIC-944)——口服选择性 EED别构型PRC2表观遗传抑制剂【药品分享】Empasiprubart注射用浓溶液——全球首创靶向补体C2人源化IgG1清扫型单克隆抗体【药品分享】阿更葡糖钠注射液——全球第二款、中国首款自主研发的环糊精类靶向肌松逆转剂【药品分享】盐酸罗哌卡因缓释溶液——国产自主长效局麻缓释制剂 || 填补国内切口原位长效镇痛空白【药品分享】Telisotuzumab Adizutecan 注射用粉末——抗c-Met抗体偶联药物（ADC）【药品分享】L606 (曲前列尼尔脂质体吸入混悬液)——靶向肺动脉高压【药品分享】佩米替尼片——选择性FGFR1/2/3酪氨酸激酶抑制剂【药品分享】唑尼沙胺胶囊——磺酰胺类结构 || 广谱抗癫痫药，偏头痛预防【药品分享】琥珀酸安维吖啶片——双靶点胆碱酯酶抑制剂【药品分享】布莱昔替尼片（Bleximenib）——口服高选择性Menin-KMT2A相互作用抑制剂【药品分享】利厄替尼片——第三代EGFR-TKI靶向药【药品分享】注射用苯磺酸瑞马唑仑——苯二氮䓬类短效静脉镇静/麻醉药【药品分享】瑞维鲁胺片——国产全新二代雄激素受体抑制剂免责声明：本文仅作医药信息传播分享，并不构成投资或决策建议。

2026-07-20

·ioncology

ESMO 2026丨瞭望前瞻，百余项中国乳腺癌研究亮相ESMO，一文速览

点击蓝字，关注我们编者按：2026年欧洲肿瘤内科学会年会（ESMO 2026）将于10月23日至27日在西班牙马德里召开。作为全球肿瘤领域最具影响力的年度盛会之一，ESMO每年覆盖基础研究、转化医学与临床诊疗全维度前沿进展，是国际肿瘤学界交流学术成果、更新诊疗理念的核心平台。目前，ESMO官网已公布部分摘要标题，《肿瘤瞭望》特针对乳腺癌领域的中国入选研究进行系统梳理，供读者提前把握本次大会的中国学术动态。（由于目前多数研究摘要全文尚未正式发布，本次整理仅基于已公开的标题信息，如有疏漏或表述偏差，敬请留言指正。）快速口头报告摘要号：4RO 英文标题：Target switching with conserved-payload novel ADCs in patients with metastatic breast cancer following prior ADC therapy (SWITCH): a prospective, open-label, phase 2 platform trial 中文标题：转移性乳腺癌ADC经治后采用同载荷异载荷新型ADC的靶点转换研究：一项前瞻性、开放标签的 II 期平台试验（SWITCH）讲者：刘西禹 (复旦大学附属肿瘤医院) 摘要号：5RO 英文标题：Safety and efficacy of SYS6043, a Novel B7-H3–Targeting Antibody-Drug Conjugate, in Patients with Advanced breast cancer 中文标题：新型靶向B7-H3 ADC SYS6043治疗晚期乳腺癌的安全性与有效性讲者：王红霞 (复旦大学附属肿瘤医院) 摘要号：4639RO 英文标题：Final OS analysis of sacituzumab tirumotecan versus chemotherapy in previously treated locally recurrent or metastatic triple-negative breast cancer: Phase III OptiTROP-Breast01 中文标题：芦康沙妥珠单抗对比化疗用于既往经治局部复发或转移性三阴性乳腺癌的III期OptiTROP-Breast01研究最终OS分析讲者：樊英 (中国医学科学院肿瘤医院) 摘要号：4640RO 英文标题：Bulumtatug Fuvedotin (BFv, 9MW2821), a Nectin-4–Directed Antibody-Drug Conjugate (ADC), in Patients with Locally Advanced or Metastatic Triple Negative Breast Cancer (la/mTNBC) Previously Treated with Topoisomerase I Inhibitor (TopI)-Based ADCs: Results from a Phase 2 Study 中文标题：新型靶向Nectin-4 ADC bulumtatug Fuvedotin（BFv，9MW2821）在既往接受过拓扑异构酶I抑制剂为基础的ADC治疗的局部晚期或转移性三阴性乳腺癌（la/mTNBC）患者中显示出显著疗效：一项II期临床研究的结果讲者：张剑 (复旦大学附属肿瘤医院) 壁报 Basic science（基础科学）摘要号：399P 英文标题：C15orf48 drives breast cancer liver metastasis via glutathione dependent activation of Wnt/β-catenin signaling 中文标题：C15orf48通过谷胱甘肽依赖性激活Wnt/β-catenin信号通路驱动乳腺癌肝转移讲者：宋振川（河北医科大学第四医院） Advanced breast cancer, other（晚期乳腺癌，其他）摘要号：6P 英文标题：Machine learning model based on pathomics features predicts T-DXd response in advanced breast cancer 中文标题：基于病理组学特征的机器学习模型可预测晚期乳腺癌对T-DXd治疗的反应讲者：刘月平（河北医科大学第四医院）摘要号：10P 英文标题：A randomized phase 3 study of disitamab vedotin (DV) versus chemotherapy (chemo) in HER2-low advanced breast cancer: overall and the liver metastasis (BCLM) subgroup results 中文标题：维迪西妥单抗对比化疗治疗HER2低表达晚期乳腺癌的随机III期研究：总体及肝转移亚组结果讲者：王佳玉（中国医学科学院肿瘤医院）摘要号：19P 英文标题：Ribociclib plus endocrine therapy versus chemotherapy in patients with rapidly progressive HR+/HER2− advanced breast cancer: a multicenter phase II study with external controls 中文标题：瑞波西利联合内分泌治疗对比化疗用于快速进展HR+/HER2−晚期乳腺癌：一项多中心II期研究及外部对照讲者：Min Tian (Nanjing, China) 摘要号：26P 英文标题：Efficacy and Safety of Anlotinib-Based Therapy in Advanced Breast Cancer: A Real-World Study 中文标题：以安罗替尼为基础方案治疗晚期乳腺癌的真实世界疗效与安全性研究讲者：姚静（华中科技大学同济医学院附属协和医院）摘要号：27P 英文标题：Local treatment in metastatic breast cancer with oligoprogression: a retrospective cohort study and reconstructive individual patient data meta-analysis 中文标题：寡进展转移性乳腺癌的局部治疗：回顾性队列研究与重建个体患者数据荟萃分析讲者：Haoting Shi (Shanghai, China) 摘要号：73eP 英文标题：Chidamide combined with Vinorelbine and Capecitabine for HER2-Negative Advanced Breast Cancer: A Single-Arm, Single-Center, Phase II Clinical Trial 中文标题：西达本胺联合长春瑞滨和卡培他滨治疗HER2阴性晚期乳腺癌：一项单臂、单中心II期临床试验讲者：La Zou (Chongqing, China) 摘要号：74eP 英文标题：Intraventricular thiotepa in combination with methotrexate for leptomeningeal metastasis from breast cancer (NJMU-BC04): a single-arm phase II study 中文标题：脑室内注射塞替哌联合甲氨蝶呤治疗乳腺癌软脑膜转移（NJMU-BC04）：一项单臂II期研究讲者：Mengyao Zha (Nanjing, China) 摘要号：79eP 英文标题：Eribulin After Antibody-Drug Conjugate Treatment in Metastatic Breast Cancer: A Real-World Multicenter Retrospective Study 中文标题：抗体偶联药物治疗后应用艾立布林治疗转移性乳腺癌：一项真实世界多中心回顾性研究讲者：邵彬（北京大学肿瘤医院）摘要号：83eP 英文标题：An EGFR dominating triple positive tumor clone engages cycling M2 macrophages during disease progression following bispecific HER3/EGFR antibody-drug conjugate (ADC) treatment in metastatic breast cancer 中文标题：EGFR主导的三阳性肿瘤克隆在转移性乳腺癌双特异性HER3/EGFR ADC治疗后疾病进展中招募循环M2巨噬细胞讲者：吕铮（吉林大学第一医院）摘要号：96eP 英文标题：Real-world effectiveness of antibody-drug conjugates versus conventional systemic therapies in metastatic breast cancer: An inverse probability of treatment weighting analysis 抗体偶联药物对比传统全身治疗在转移性乳腺癌中的真实世界疗效：逆概率处理加权分析讲者：Shukai Guo (Fuzhou, China) Breast cancer, early stage（早期乳腺癌）摘要号：547P 英文标题：Predictive Role of ctDNA for Pseudoprogression in Triple-Negative Breast Cancer during Neoadjuvant Immunotherapy 中文标题：ctDNA在三阴性乳腺癌新辅助免疫治疗期间假性进展的预测作用讲者：王永胜（山东省肿瘤医院）摘要号：560P 英文标题：Efficacy and Safety of Pyrotinib Combined with Trastuzumab and Aromatase Inhibitor in Neoadjuvant Treatment of HER2+/HR+ Breast Cancer: A Single-Arm, Multi-Center Phase II Exploratory Study 中文标题：吡咯替尼联合曲妥珠单抗和芳香化酶抑制剂新辅助治疗HR+/HER2+乳腺癌：一项单臂、多中心II期探索性研究讲者：葛洁（天津医科大学肿瘤医院）摘要号：570P 英文标题：Qualitative synergism between female hormone use and secondhand smoke on breast carcinogenesis: A prospective cohort study 中文标题：雌激素使用与二手烟在乳腺癌发生中的定性协同作用：一项前瞻性队列研究讲者：Hong-Hong Zhu (Quzhou, China) 摘要号：580P 英文标题：Ki-67-Guided Stratification and Resistance Mechanism Analysis of CDK4/6 Inhibitor Therapy Following Adaptive Neoadjuvant Endocrine Treatment in HR+/HER2− Breast Cancer 中文标题：HR+/HER2-乳腺癌中适应性新辅助内分泌治疗后CDK4/6抑制剂治疗的Ki-67引导分层与耐药机制分析讲者：王永胜（山东省肿瘤医院）摘要号：616eP 英文标题：Radiotherapy-Integrated Neoadjuvant Therapy Deepens Response and Expands Eligibility for Surgery Omission in TNBC and HR-/HER2+ Breast Cancer: Interim Analysis of a Multicenter Phase II Study 中文标题：放疗联合新辅助治疗可增强对TNBC和HR-/HER2+乳腺癌的疗效，并扩大免手术治疗发适应证：一项多中心II期研究期中分析讲者：杨正军（天津医科大学肿瘤医院）摘要号：617eP 英文标题：Ultrasound-Guided Vacuum-Assisted Excision Followed by Definitive Surgery in Early-Stage Small Breast Cancer: A Single-Arm Trial 中文标题：超声引导下真空辅助旋切术后续根治性手术治疗早期小乳腺癌：一项单臂试验讲者：Siyuan Wang (Xi'an, China) 摘要号：628eP 英文标题：Extended Sentinel Lymph Node Biopsy Using a Single Tracer After Neoadjuvant Therapy for Breast Cancer: A Retrospective Real-World Study 中文标题：乳腺癌新辅助治疗后应用单一示踪剂的扩展前哨淋巴结活检：一项回顾性真实世界研究讲者：张聚良（空军军医大学西京医院）摘要号：635eP 英文标题：Profound Vitamin D Deficiency Identifies Elevated Heart Failure Risk Among Breast Cancer Survivors: A UK Biobank Multi-State Analysis 中文标题：重度维生素D缺乏识别乳腺癌幸存者中升高的心力衰竭风险：一项UK Biobank多状态分析讲者：Yiyin Zhang (Beijing, China) 摘要号：636eP 英文标题：A novel single-molecule dual CDK4/CDK2 inhibitor series with cytotoxic cellular activity and improved kinome selectivity for HR+/HER2− breast cancer and CCNE1-amplified ovarian cancer 中文标题：新型单分子双靶点CDK4/CDK2抑制剂系列：针对HR+/HER2−乳腺癌和CCNE1扩增卵巢癌具有细胞毒活性和改善的激酶组选择性讲者：Xianqiang Sun (Shanghai, China) 摘要号：639eP 英文标题：Carbon Nano-Lymph Tracer in Modified Radical Mastectomy After Neoadjuvant Chemotherapy for Breast Cancer 中文标题：纳米碳淋巴示踪剂在乳腺癌新辅助化疗后改良根治术中的应用讲者：Feng Liu (Fuyang, China, Anhui) 摘要号：646eP 英文标题：Patient and Oncologist Preferences Regarding CDK4/6 Inhibitor Adjuvant Therapy for HR+/HER2- Early Breast Cancer in China 中文标题：中国HR+/HER2−早期乳腺癌患者与肿瘤科医生对CDK4/6抑制剂辅助治疗的偏好讲者：郝春芳（天津医科大学肿瘤医院）摘要号：648eP 英文标题：Standard imaging-guided, Doppler-free chest wall perforator flap reconstruction for granulomatous lobular mastitis: A simplified approach for resource-limited settings 中文标题：标准影像引导下，无多普勒胸壁穿支皮瓣重建术治疗肉芽肿性小叶性乳腺炎：面向资源有限地区的简化方案讲者：王子莹（常州市第一人民医院） HER2+ breast cancer（HER2阳性乳腺癌）摘要号：1772P 英文标题：A Study Evaluating the Safety and Efficacy of Pyrotinib Dose Escalation Plus Loperamide Prophylaxis in First-Line Treatment of Advanced HER2-Positive Breast Cancer 中文标题：一项评估吡咯替尼剂量递增联合洛哌丁胺预防HER2阳性晚期乳腺癌一线治疗中安全性与有效性的研究讲者：晁腾飞（华中科技大学同济医学院附属同济医院）摘要号：1773P 英文标题：Neoadjuvant Oral Paclitaxel Plus Subcutaneous Fixed-Dose Pertuzumab/Trastuzumab in Stage II-III HER2+ Breast Cancer: First-Stage Results from a Simon's Two-Stage Study 中文标题：口服紫杉醇联合皮下注射固定剂量帕妥珠单抗/曲妥珠单抗新辅助治疗II-III期HER2+乳腺癌：Simon两阶段设计第一阶段结果讲者：Yudong Li (Guangzhou, China) 摘要号：1775P 英文标题：Dalpiciclib plus Pyrotinib-Based Chemotherapy-Free Regimens as first line treatment in Trastuzumab-Sensitive, HER2-Positive Metastatic Breast Cancer (DAP-HER-02): A Dual-Cohort, Phase II Study 中文标题：达尔西利联合吡咯替尼无化疗方案一线治疗曲妥珠单抗敏感的HER2阳性转移性乳腺癌（DAP-HER-02）：一项双队列II期研究讲者：牛李敏（郑州大学第一附属医院）摘要号：1776P 英文标题：IBI354 plus pertuzumab as first-line (1L) treatment for patients with HER2-positive, unresectable locally advanced or metastatic breast cancer: Results from a phase 2 study 中文标题：IBI354联合帕妥珠单抗一线治疗HER2阳性不可切除局部晚期或转移性乳腺癌：一项II期研究结果讲者：曾晓华（重庆大学附属肿瘤医院）摘要号：1778P 英文标题：Updated results of SHR-A1811 plus pertuzumab in human epidermal growth factor receptor 2-positive (HER2+) unresectable/metastatic breast cancer: a phase 1b/2 study 中文标题：SHR-A1811联合帕妥珠单抗治疗HER2阳性不可切除/转移性乳腺癌的更新结果：一项Ib/II期研究讲者：黄香（南京医科大学第一附属医院）摘要号：1779P 英文标题：Prognostic Impact of PIK3CA Mutations in HER2-Positive Advanced Breast Cancer: A Real-World Multicenter Study 中文标题：PIK3CA突变对HER2阳性晚期乳腺癌的预后影响：一项真实世界多中心研究讲者：王瓯晨（温州医科大学附属第一医院）摘要号：1781P 英文标题：Real-World Comparative Study of Pertuzumab- vs Pyrotinib-Based First-Line Regimens in HER2-Positive Advanced Breast Cancer: A Xinjiang Multicenter Study 中文标题：帕妥珠单抗对比吡咯替尼一线治疗HER2阳性晚期乳腺癌的真实世界比较：一项新疆多中心研究讲者：赵兵（新疆医科大学附属肿瘤医院）摘要号：1802eP 英文标题：Neoadjuvant Chemotherapy plus Pyrotinib and Trastuzumab for HER2-positive Breast Cancer: A Prospective, Single-arm, Multi-center Study (NEOTORCH-BREAST05) 中文标题：新辅助化疗联合吡咯替尼和曲妥珠单抗治疗HER2阳性乳腺癌：一项前瞻性、单臂、多中心研究（NEOTORCH-BREAST05）讲者：Zhijun Dai (Hangzhou, China) 摘要号：1803eP 英文标题：Multicenter, phase II study of eribulin, carboplatin, trastuzumab and pertuzumab as neoadjuvant therapy in HER2-positive early or locally advanced breast cancer 中文标题：艾立布林、卡铂、曲妥珠单抗和帕妥珠单抗新辅助治疗HER2阳性早期或局部晚期乳腺癌的多中心II期研究讲者：Di Lu (Chengdu, China) 摘要号：1810eP 英文标题：Inetetamab Combined with Pyrotinib for HER2-Positive Advanced Breast Cancer: A Multicenter Real-World Retrospective Study 中文标题：伊尼妥单抗联合吡咯替尼治疗HER2阳性晚期乳腺癌：一项多中心真实世界回顾性研究讲者：Zenggui Wu (Taizhou, China) 摘要号：1812eP 英文标题：Enhanced protein lactylation accompanies acquired resistance to trastuzumab deruxtecan in HER2-positive breast cancer 中文标题：增强的蛋白乳酰化伴随HER2阳性乳腺癌对德曲妥珠单抗的获得性耐药讲者：Nan Jin (Nanjing, China) 摘要号：1814eP 英文标题：Antibody-programmable MOFs reshape multi-dimensional intervention strategies for programmed cell death in HER2+ breast cancer 中文标题：抗体可编程金属有机框架重塑HER2+乳腺癌程序性细胞死亡的多维干预策略讲者：王宇（首都医科大学附属北京同仁医院）摘要号：1818eP 英文标题：Characterization of Antibody Drug Conjugate-Associated Interstitial Lung Disease in Breast Cancer: A Systematic Review and Meta-Analysis 中文标题：乳腺癌抗体偶联药物相关间质性肺病的特征：系统综述与荟萃分析讲者：Yinuo Dong (Beijing, China) 摘要号：1823eP 英文标题：Ranking of First-Line Treatments for Advanced HER2-Positive Breast Cancer: A Bayesian Network Meta-Analysis 中文标题：HER2阳性晚期乳腺癌一线治疗的排序：贝叶斯网络荟萃分析讲者：Yuxin Sun (Beijing, China) 摘要号：1828eP 英文标题：Breast Ultrasound for Early Prediction of Response to Neoadjuvant Therapy in HER2-Positive Breast Cancer: A Real-World Analysis 中文标题：乳腺超声用于HER2阳性乳腺癌新辅助治疗疗效早期预测的真实世界分析讲者：Yuhang Xiao (Nanjing, China) 摘要号：1838eP 英文标题：FAP Expression Heterogeneity Drives Efficacy Variation of Targeted Radioligand Therapy and Patient Selection in HER2-Positive Breast Cancer 中文标题：FAP表达异质性驱动HER2阳性乳腺癌靶向放射性配体治疗的疗效差异与患者筛选讲者：Ting Wu (Luzhou, China) 摘要号：1841eTiP 英文标题：Al18F-HER2-BCH PET/CT guided precision neoadjuvant therapy for HER2-positive early breast cancer: FHERNAT trial 中文标题：Al18F-HER2-BCH PET/CT引导的HER2阳性早期乳腺癌精准新辅助治疗：FHERNAT试验讲者：梁旭（北京大学肿瘤医院） HR+ breast cancer（激素受体阳性乳腺癌）摘要号：1847P 英文标题：SHR-A2102, a Nectin-4-directed antibody drug conjugate (ADC), in pretreated HR+/HER2- advanced breast cancer: results from a phase 1 study 中文标题：SHR-A2102（靶向Nectin-4的ADC）用于经治HR+/HER2−晚期乳腺癌：一项I期研究结果讲者：闫敏（郑州大学附属肿瘤医院）摘要号：1848P 英文标题：First-in-human study of JYP0035, a highly selective PI3Kα inhibitor, as monotherapy in patients with advanced solid tumors 中文标题：高选择性PI3Kα抑制剂JYP0035单药治疗晚期实体瘤的首次人体研究讲者：孟艳春（复旦大学附属肿瘤医院）摘要号：1849P 英文标题：A Phase 1b/2 Study of JS105 in Combination with Dalpiciclib and Fulvestrant in Patients with Advanced Breast Cancer 中文标题：JS105联合达尔西利和氟维司群治疗晚期乳腺癌的Ib/II期研究讲者：闫敏（郑州大学附属肿瘤医院）摘要号：1852P 英文标题：Evaluation of the safety and efficacy of SH3765 in combination with fulvestrant in HR+/HER2− advanced breast cancer: a phase Ib study 中文标题：SH3765联合氟维司群治疗HR+/HER2−晚期乳腺癌的安全性与疗效评估：一项Ib期研究讲者：潘跃银（中国科学技术大学附属第一医院）摘要号：1858P 英文标题：BL0175 Injection for Locally Advanced/Metastatic HR+/HER2− Breast Cancer: Preliminary Results from Dose Escalation Stage of a Phase 1 Study 中文标题：BL0175注射液治疗局部晚期/转移性HR+/HER2−乳腺癌：I期剂量递增阶段初步结果讲者：王楠娅（吉林大学第一医院）摘要号：1859P 英文标题：First-line fovinaciclib for advanced breast cancer: updated analysis of a randomized, double-blind phase 3 study 中文标题：伏维西利一线治疗晚期乳腺癌：随机双盲III期研究更新分析讲者：袁芃（中国医学科学院肿瘤医院）摘要号：1869P 英文标题：Lysine acetyltransferase 6A (KAT6A) for predicting tamoxifen resistance in hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2-) early breast cancer 中文标题：赖氨酸乙酰转移酶6A预测HR+/HER2−早期乳腺癌他莫昔芬耐药讲者：Tan Yujing (Beijing, China) 摘要号：1881P 英文标题：Clinical outcomes of YL202/BNT326 (HER3 ADC) in advanced/metastatic HR+/HER2-null/low breast cancer in chemotherapy-naïve and exposed patients 中文标题：YL202/BNT326（HER3 ADC）在初治和经治晚期/转移性HR+/HER2零表达/低表达乳腺癌中的临床结局讲者：孟艳春（复旦大学附属肿瘤医院）摘要号：1886TiP 英文标题：A phase I/II study of GenSci145 as monotherapy or combination therapy in PIK3CA-mutated advanced solid tumors 中文标题：GenSci145单药或联合治疗PIK3CA突变晚期实体瘤的I/II期研究讲者：徐兵河（中国医学科学院肿瘤医院）摘要号：1890eP 英文标题：Integrated Molecular Profiling of Paired Tumor Tissue and Circulating Tumor DNA in Chinese Patients with HR+/HER2- Advanced Breast Cancer Prior to First-Line Systemic Therapy 中文标题：中国HR+/HER2−晚期乳腺癌患者一线全身治疗前配对肿瘤组织与循环肿瘤DNA的整合分子分型讲者：岳健（中国医学科学院肿瘤医院）摘要号：1892eP 英文标题：An Open-label, Single-arm Study of Dalpiciclib in Combination with Aromatase Inhibitor and Capecitabine as Neoadjuvant Therapy for high-risk HR+/HER2- Early Breast Cancer 中文标题：达尔西利联合芳香化酶抑制剂和卡培他滨新辅助治疗高危HR+/HER2−早期乳腺癌：一项开放标签、单臂研究讲者：韩忠华（福建医科大学附属协和医院）摘要号：1893eP 英文标题：Dalpiciclib combined with endocrine therapy and capecitabine in high-risk HR+/HER2- advanced breast cancer: a multicenter phase II study 中文标题：达尔西利联合内分泌治疗和卡培他滨治疗高危HR+/HER2−晚期乳腺癌：一项多中心II期研究讲者：张捷（福建医科大学附属协和医院）摘要号：1895eP 英文标题：Early Toxicity-Driven Dose Modification Preserves Efficacy of Adjuvant Abemaciclib in High-Risk HR+/HER2− Early Breast Cancer: A Real-World Study in Chinese Patients 中文标题：早期毒性驱动的剂量调整不影响高危HR+/HER2−早期乳腺癌辅助阿贝西利疗效：一项中国患者真实世界研究讲者：Jing Huang (Xi'an, China) 摘要号：1896eP 英文标题：Fruquintinib plus eribulin in patients with metastatic HR+, HER2- breast cancer after progression on endocrine therapy plus CDK4/6 inhibitor: Updated results from a phase II study 中文标题：呋喹替尼联合艾立布林治疗内分泌治疗联合CDK4/6抑制剂进展后的转移性HR+/HER2−乳腺癌：II期研究更新结果讲者：袁渊（南京医科大学第一附属医院）摘要号：1898eP 英文标题：Real-World Outcomes of First-Line CDK4/6 Inhibitors Plus Endocrine Therapy in HR+/HER2- Advanced Breast Cancer: A Large National Cohort Study in China 中文标题：CDK4/6抑制剂联合内分泌治疗一线治疗HR+/HER2−晚期乳腺癌的真实世界结局：中国大型全国性队列研究讲者：罗扬（中国医学科学院肿瘤医院）摘要号：1903eP 英文标题：Patient-reported outcomes after switching from goserelin implant to goserelin microsphere in breast cancer: preliminary results of a prospective study 中文标题：乳腺癌患者从戈舍瑞林植入剂转换为戈舍瑞林微球后的患者报告结局：一项前瞻性研究初步结果讲者：张蓝心（大连医科大学附属第二医院）摘要号：1904eP 英文标题：CPS-EG Combined With Postoperative Ki-67 Outperforms ypTNM for Prognostication in HR+/HER2- Breast Cancer After Neoadjuvant Therapy: An 801-Patient Single-Center Retrospective Cohort Study 中文标题：CPS-EG联合术后Ki-67对HR+/HER2−乳腺癌新辅助治疗后预后的预测价值优于ypTNM：一项801例患者单中心回顾性队列研究讲者：Tian Yi Zhou (Guangzhou, China) 摘要号：1907eP 英文标题：Real-World Effectiveness and Safety of the Novel Agent Inavolisib in Heavily Pretreated, PIK3CA-mut Advanced Breast Cancer: A Multicenter Study of Patients with More Advanced and Complex Disease 中文标题：伊那利塞在重度经治PIK3CA突变晚期乳腺癌中的真实世界疗效与安全性：一项针对病情更晚期复杂疾病患者的多中心研究讲者：梁旭（北京大学肿瘤医院）摘要号：1911eP 英文标题：Optimal sequencing of systemic therapies for HR+/HER2− advanced breast cancer stratified by visceral and liver metastases: a systematic review and network meta-analysis 中文标题：按内脏和肝转移分层HR+/HER2−晚期乳腺癌全身治疗的最佳序贯策略：系统综述与网络荟萃分析讲者：Hong Cheng (Beijing, China) 摘要号：1918eP 英文标题：ABC-RWS-01 interim analysis of elacestrant in Chinese ESR1-mutated ER+/HER2- advanced breast cancer 中文标题：Elacestrant治疗中国ESR1突变ER+/HER2−晚期乳腺癌的ABC-RWS-01研究期中分析讲者：Wenbo Shi (Qionghai, China) 摘要号：1923eP 英文标题：Real-World Effectiveness and Safety of Maintenance Endocrine Therapy With or Without CDK4/6 Inhibitors Following Chemotherapy in HR-Positive/HER2-Negative Advanced Breast Cancer 中文标题：HR+/HER2-晚期乳腺癌化疗后维持内分泌治疗联合或不联合CDK4/6抑制剂的真实世界疗效与安全性讲者：李慧慧（山东省肿瘤医院）摘要号：1929eP 英文标题：Characterization of PIK3CA variants and real-world clinical evolution of first-line CDK4/6 inhibitors: Insights from a Chinese HR+/HER2- advanced breast cancer cohort 中文标题：PIK3CA变异特征与一线CDK4/6抑制剂治疗的真实世界临床演变：来自中国HR+/HER2−晚期乳腺癌队列的见解讲者：石晶（中国医科大学附属第一医院）摘要号：1936eP 英文标题：Safety profile of exemestane vs. anastrozole in the real world: a disproportionality analysis of FAERS database and systematic review of case reports 中文标题：依西美坦对比阿那曲唑的真实世界安全性：FAERS数据库不相称性分析与病例报告系统综述讲者：Chunsu Liang (Beijing, China) 摘要号：1943eTiP 英文标题：SoGreat: A phase Ib modular study of sacituzumab govitecan plus endocrine therapy in HR-positive/HER2-negative metastatic breast cancer after progression on CDK4/6 inhibitors 中文标题：SoGreat：戈沙妥珠单抗联合内分泌治疗用于CDK4/6抑制剂进展后HR+/HER2-转移性乳腺癌的Ib期模块化研究讲者：Zhonghui Zheng (Shanghai, China) 摘要号：1944eTiP 英文标题：The NASA (Neoadjuvant Ribociclib plus Aromatase Inhibitor) Trial: A randomized comparison versus chemotherapy in HR+/HER2- EBC 中文标题：NASA试验（新辅助哌柏西利联合芳香化酶抑制剂）：HR+/HER2−早期乳腺癌中对比化疗的随机对照研究讲者：蔡子杰（中山大学孙逸仙纪念医院） Supportive care（支持治疗）摘要号：3950P 英文标题：Musculoskeletal pain, neutrophil recovery kinetics, and exploratory immune-profiling with telpegfilgrastim versus other long-acting G-CSFs in breast cancer: TELEGRAM 中文标题：乳腺癌中拓培非格司亭对比其他长效G-CSF的肌肉骨骼疼痛、中性粒细胞恢复动力学及探索性免疫分型：TELEGRAM研究讲者：李薇（南京医科大学第一附属医院）摘要号：4028eP 英文标题：Efficacy and safety of telpegfilgrastim in breast cancer patients undergoing (neo)adjuvant chemotherapy for prophylaxis of chemotherapy-induced neutropenia: A multicenter, prospective, observational study 中文标题：拓培非格司亭在乳腺癌（新）辅助化疗患者预防化疗所致中性粒细胞减少的疗效与安全性：一项多中心、前瞻性、观察性研究讲者：张少华（解放军总医院）摘要号：4057eP 英文标题：Prospective Cohort Study on the Prophylaxis of Catheter-related Thrombosis in Breast Cancer Patients 中文标题：乳腺癌患者导管相关血栓预防的前瞻性队列研究讲者：Shiyu Li (Beijing, China) 摘要号：4071eP 英文标题：Auricular point stimulation plus dexamethasone for nausea and vomiting caused by docetaxel combined with cyclophosphamide in breast cancer adjuvant chemotherapy (ADDC) 中文标题：耳穴刺激联合地塞米松用于乳腺癌辅助化疗多西他赛联合环磷酰胺所致恶心呕吐（ADDC研究）讲者：Juan Wang (Hangzhou, China) 摘要号：4138eP 英文标题：Physiological and Functional Responses to Ultrasound-Guided Dextrose Hydrodissection in Breast Cancer Survivors With Persistent Chest Wall and Axillary Tightness 中文标题：超声引导下葡萄糖水分离术对持续性胸壁和腋窝紧绷的乳腺癌幸存者的生理与功能反应讲者：Yuchun Lee（中国台湾台中市） Triple negative breast cancer（三阴性乳腺癌）摘要号：4651P 英文标题：Competing risk nomogram for cancer-specific mortality and risk-stratified treatment associations in women with T2N0M0 triple-negative breast cancer: a SEER study (2010-2016) 中文标题：T2N0M0三阴性乳腺癌患者癌症特异性死亡竞争风险列线图及风险分层治疗关联：一项SEER研究（2010-2016）讲者：Sirui Zhu (Beijing, China) 摘要号：4652P 英文标题：225Ac-PSMA-targeted alpha therapy (TRC003) in metastatic TNBC: A prospective, multicenter, single-arm safety/efficacy trial 中文标题：225Ac-PSMA靶向α核素治疗（TRC003）在转移性TNBC中的应用：一项前瞻性、多中心、单臂安全性与疗效试验讲者：孙晓蓉（山东第一医科大学附属肿瘤医院）摘要号：4653P 英文标题：A phase 2, multicenter, open-label study to evaluate the efficacy and safety of ATRA plus toripalimab and chemotherapy in patients with previously treated locally advanced or metastatic triple-negative breast cancer 中文标题：ATRA联合特瑞普利单抗和化疗治疗经治局部晚期或转移性三阴性乳腺癌的II期多中心开放标签研究讲者：陶中华（复旦大学附属肿瘤医院）摘要号：4655P 英文标题：Efficacy and Safety of First-Line Treatment for Advanced Triple-Negative Breast Cancer: A Network Meta-Analysis of Randomized Controlled Trials 中文标题：晚期三阴性乳腺癌一线治疗的疗效与安全性：随机对照试验网络荟萃分析讲者：Junxiao Wang (Fuzhou, China) 摘要号：4657P 英文标题：Subtyping-guided addition of bevacizumab to treatment of physician's choice for previously untreated, advanced, basal-like immune-suppressed triple-negative breast cancer (OASIS/BCTOP-T-M01): a randomised, multicentre, phase 3 trial 中文标题：分型指导的贝伐珠单抗联合医生选择方案治疗初治晚期基底样免疫抑制型三阴性乳腺癌（OASIS/BCTOP-T-M01）：一项随机、多中心III期试验讲者：马林晓曦（复旦大学附属肿瘤医院）摘要号：4678P 英文标题：The Efficacy and Safety of Utidelone Plus Tislelizumab and Bevacizumab for Advanced or Metastatic Triple-negative Breast Cancer (UTILIZABLE) 中文标题：优替德隆联合替雷利珠单抗和贝伐珠单抗治疗晚期或转移性三阴性乳腺癌（UTILIZABLE研究）讲者：Qingxu Liu (Wuhan, China) 摘要号：4680eP 英文标题：Identification of angiogenesis-related diagnostic and prognostic gene signatures for triple-negative breast cancer via machine learning and single-cell analysis 中文标题：基于机器学习和单细胞分析鉴定三阴性乳腺癌血管生成相关诊断和预后基因特征讲者：Hanbo Wang (Tianjin, China) 摘要号：4682eP 英文标题：Isojacareubin induces apoptosis of chemoresistant-triple negative breast cancer by epigenetic repression of PIK3CA via deacetylation of Histone 3 lysine 56 中文标题：异山竹素通过组蛋白H3K56去乙酰化表观遗传抑制PIK3CA诱导化疗耐药三阴性乳腺癌凋亡讲者：Dar-Ren Chen（中国台湾彰化市）摘要号：4686eP 英文标题：Single-cell transcriptomics reveals drivers of tumor microenvironment reprogramming and immunotherapy resistance in triple-negative breast cancer 中文标题：单细胞转录组学揭示三阴性乳腺癌肿瘤微环境重编程和免疫治疗耐药的驱动因素讲者：Shuangqi Qian (Tianjin, China) 摘要号：4690eP 英文标题：Association of PCSK9 Inhibitor Use With Breast Cancer Survival and Recurrence: A Target Trial Emulation 中文标题：PCSK9抑制剂使用与乳腺癌生存和复发的关联：目标试验模拟讲者：Salida Ali（中国香港）摘要号：4693eP 英文标题：PD-1 Inhibitor Sintilimab Concurrent with Epirubicin, Cyclophosphamide, and Nab-Paclitaxel as Neoadjuvant Therapy for Triple-Negative Breast Cancer: A Single-Arm, Phase II Study 中文标题：PD-1抑制剂信迪利单抗联合表柔比星、环磷酰胺和白蛋白紫杉醇新辅助治疗三阴性乳腺癌：一项单臂II期研究讲者：Duanyang Zhai (Guangzhou, China) 摘要号：4695eP 英文标题：Carboplatin plus taxanes combined with or without PD-1 inhibitors as neoadjuvant therapy in triple-negative breast cancer: A Propensity-Matched Cohort Study 中文标题：卡铂联合紫杉类联合或不联合PD-1抑制剂新辅助治疗三阴性乳腺癌：一项倾向性匹配队列研究讲者：Hongwei Lyu (Beijing, China) 摘要号：4700eP 英文标题：Radiological Complete Response as a Predictor of Neoadjuvant Therapy Efficacy in Early Triple-Negative Breast Cancer: A Multicenter Real-World Study 中文标题：影像学完全缓解作为早期三阴性乳腺癌新辅助治疗疗效的预测因素：一项多中心真实世界研究讲者：Wenyu Yang (Beijing, China) 摘要号：4702eP 英文标题：A Tumor Cell Membrane-Based FTY720 Nanoplatform Synergizes with [177Lu]Lu Radionuclide Therapy for Triple-Negative Breast Cancer 中文标题：基于肿瘤细胞膜的FTY720纳米平台协同[177Lu]Lu放射性核素治疗三阴性乳腺癌讲者：Yuyue Hou (Wuhan, China) 摘要号：4724eP 英文标题：Predictive value of tertiary lymphoid structures for immunotherapy efficacy in triple-negative breast cancer 讲者：三级淋巴结构对三阴性乳腺癌免疫治疗疗效的预测价值讲者：刘月平（河北医科大学第四医院）摘要号：4732eP 英文标题：Landscape of Peripheral Immune Response Induced by Multimodal Thermal Therapy Combined with Chemoimmunotherapy in Patients with Early-stage Triple-negative Breast Cancer 中文标题：多模式热疗联合化学免疫治疗诱导早期三阴性乳腺癌患者外周免疫应答的全景分析讲者：Fei Lin Qu (Shanghai, China) AI for clinical workflows and decision-making（人工智能辅助临床工作流程与决策）摘要号：208P 英文标题：Multimodal Unified Survival Ensemble (MUSE) Predicts Immunotherapy Survival Benefit in Triple-negative Breast Cancer (TNBC): Analysis from the TORCHLIGHT Study 中文标题：多模态统一生存集成模型预测三阴性乳腺癌免疫治疗生存获益：TORCHLIGHT研究分析讲者：江泽飞（解放军总医院） AI for diagnostics and profiling (pathology, radiology, molecular biology)（人工智能辅助诊断与分子分型）摘要号：300P 英文标题：BRIGHT: a breast pathology foundation model for biomarker prediction and treatment stratification in breast cancer 中文标题：BRIGHT：用于乳腺癌生物标志物预测与治疗分层的基础病理模型讲者：刘芳芳（天津医科大学肿瘤医院）摘要号：314P 英文标题：Study on the association between HER2 expression in breast cancer and spatial heterogeneity of microvascular density 中文标题：乳腺癌HER2表达与微血管密度空间异质性的关联研究讲者：Jingyue Li (Shenyang, China) 摘要号：331P 英文标题：An Interpretable Whole-slide Image Framework for Automated Trop-2 H-score Assessment in Breast Cancer 中文标题：可解释的全玻片图像框架用于乳腺癌Trop-2 H-score自动评估讲者：刘月平（河北医科大学第四医院）摘要号：355P 英文标题：A Multimodal Model Integrating Therapeutic Response Patterns and AI-Powered Pathology for Survival Prediction in Breast Cancer After Neoadjuvant Therapy 中文标题：整合治疗反应模式与人工智能病理的多模态模型用于乳腺癌新辅助治疗后生存预测讲者：刘月平（河北医科大学第四医院） Developmental therapeutics（药物研发）摘要号：1119eP 英文标题：Nitazoxanide Induces Ferroptosis in Triple-Negative Breast Cancer by Dual Reprogramming of Iron Metabolism and the β-catenin/GPX4 Axis 中文标题：硝唑尼特通过双重重编程铁代谢和β-catenin/GPX4轴诱导三阴性乳腺癌铁死亡讲者：Tao He (Luzhou, China) Psycho-oncology（心理肿瘤学）摘要号：3495eP 英文标题：Machine Learning Models for Depression Risk Prediction in Breast Cancer Patients: A Cross-Sectional Study Based on the NHANES Database 中文标题：基于NHANES数据库的机器学习模型预测乳腺癌患者抑郁风险：一项横断面研究讲者：Junxiao Wang (Fuzhou, China) Translational research and biomarkers（转化研究与生物标志物）摘要号：4587eP 英文标题：Temperature-Responsive PDDNFs@QDs Integrating Simplified Isolation for Efficient Exosome Analysis Enables Breast Cancer Diagnosis and Subtyping 中文标题：温敏型PDDNFs@QDs整合简化分离实现高效外泌体分析用于乳腺癌诊断与分型讲者：Xiangyue Meng (Chengdu, China) （来源：《肿瘤瞭望》编辑部）声明凡署名原创的文章版权属《肿瘤瞭望》所有，欢迎分享、转载。本文仅供医疗卫生专业人士了解最新医药资讯参考使用，不代表本平台观点。该等信息不能以任何方式取代专业的医疗指导，也不应被视为诊疗建议，如果该信息被用于资讯以外的目的，本站及作者不承担相关责任。

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10 条最早获批的记录,

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适应症	国家/地区	公司	日期
复发性乳腺癌	中国	成都华昊中天药业有限公司	2021-03-11
转移性乳腺癌	中国	成都华昊中天药业有限公司	2021-03-11

未上市

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
晚期乳腺癌	临床3期	中国	北京华昊中天生物医药股份有限公司	2026-07-24
局部晚期胃食管交界处腺癌	临床3期	美国	北京华昊中天生物医药股份有限公司	2025-08-28
局部晚期胃食管交界处腺癌	临床3期	中国	北京华昊中天生物医药股份有限公司	2025-08-28
胃食管交界处腺癌	临床3期	中国	北京华昊中天生物医药股份有限公司	2025-07-16
胃食管交界处癌	临床3期	中国	北京华昊中天生物医药股份有限公司	2025-07-16
局部晚期非小细胞肺癌	临床3期	中国	成都华昊中天药业有限公司	2022-12-08
转移性非小细胞肺癌	临床3期	中国	成都华昊中天药业有限公司	2022-12-08
HER2 阴性乳腺癌	临床3期	中国	中山大学	2022-03-01
局部晚期乳腺癌	临床3期	中国	成都华昊中天药业有限公司	2022-03-01
局部晚期乳腺癌	临床3期	中国	中山大学	2022-03-01

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


ChiCTR2200061635 (ASCO2026)	临床2期	转移性去势抵抗性前列腺癌	43	Utidelone	廠選衊觸觸廠範窪顧壓(醖襯蓋膚膚壓餘獵構網) = 膚齋醖顧艱鹽構網築鏇窪鑰積簾壓餘艱範遞憲 (醖繭築築糧構壓鹽範夢 ) 更多	积极	2026-05-29
NCT06973421 (FRUTD, ASCO2026)	临床2期	复发性铂耐药性卵巢癌	14	Utidelone plus Fruquintinib	蓋遞顧繭遞夢鹹製齋築(鏇齋網願艱窪憲鹽窪餘) = 鹽顧構簾憲艱觸醖鏇遞繭壓夢鬱窪觸壓鏇觸窪 (顧鹹鹽膚構窪齋衊齋窪, 38.8 ~ 83.7) 更多	积极	2026-05-29
NCT05700084 (ASCO2026)	临床2期	转移性乳腺癌 HR+ \| HER2-	44	Utidelone capsule + Capecitabine	製膚鏇廠觸網鹹鑰選繭(顧顧遞願衊餘築築鬱簾) = 繭鏇繭製築憲範構網窪獵壓糧願廠餘膚餘憲鹹 (製構鹹襯獵鏇衊餘憲築, 36.7 ~ 67.5) 更多	积极	2026-05-29
ASCO2026	临床2期	HER2阳性转移性乳腺癌一线 \| 二线 HER2-positive	94	Inetetamab + Pyrotinib + Utidelone	壓觸構廠繭夢壓遞憲鑰(襯繭蓋膚膚繭窪繭鹽衊) = 繭築夢構艱鹽選壓鏇遞廠網襯餘獵廠醖選製築 (鬱廠觸範膚範範顧衊遞, 72.6 ~ 89.8) 更多	积极	2026-05-29
NCT05357417 (U-BOMB-HER, SABCS2025)	临床2期	HER2阳性乳腺癌 HER2-positive	50	Utidelone plus bevacizumab	範鬱蓋餘餘觸艱鬱夢醖(艱遞齋鬱積築窪憲築鏇) = 網夢齋鬱鹽獵壓觸鬱膚繭築構獵鏇夢觸遞夢衊 (蓋淵廠膚壓襯壓製簾選, 39.3 ~ 68.2) 更多	积极	2025-12-12
ChiCTR2200062161 (UTISARC, ESMO2025)	临床2期	转移性软组织肉瘤	27	Utidelone 30 mg/m	襯鏇憲繭積襯選構襯衊(壓觸衊網醖鹽鹹鹹廠襯) = 醖網齋選淵膚蓋夢鹽鬱鹽壓壓鏇齋鹽獵繭艱窪 (遞夢壓鬱積醖襯遞鹹衊 ) 更多	积极	2025-10-17
NCT05795920 (PRNewswire) 人工标引	临床2期	不能切除性胰腺癌一线	20	Utidelone + Gemcitabine	獵築獵鬱構鬱醖鬱選餘(壓壓艱鏇製觸艱繭淵糧) = 鹽構夢範憲獵壓簾積憲窪淵齋艱鏇襯鬱齋蓋選 (積憲積遞壓簾憲積廠衊 ) 更多	积极	2025-09-25
NCT05357417 (U-BOMB, Pubmed \| JAMA Oncol) 人工标引	临床2期	转移性HER2阴性乳腺癌 HER2/Neu Negative	47	Utidelone +Bevacizumab	鑰壓積淵鏇窪壓鹽衊顧(膚簾齋觸築淵鬱築餘製) = 夢夢蓋糧醖壓壓選鏇蓋遞鹹鏇夢獵艱鹹憲衊醖 (製築憲鹹製夢構衊鬱壓, 28.3 ~ 57.8) 更多	积极	2025-08-01
NCT05700084 (Phase I/II study of utidelone capsule, ASCO2025)	临床1/2期	晚期恶性实体瘤	31	Utidelone capsule (UTD2) 50 mg/m^2/d-5day	構獵範製憲範積齋獵網(蓋製餘顧衊鹹廠築鬱鏇) = the most common ≥ Grade 3 AE was diarrhea appeared at 75 mg/m^2/d-7day, but recovered within 24 hours after supportive treatment 憲鬱蓋糧廠網遞構憲網 (艱鑰製繭鏇觸顧襯構簾 ) 更多	积极	2025-05-30
	临床1/2期	晚期恶性实体瘤	31	Utidelone capsule (UTD2) 75 mg/m^2/d-5day		积极	2025-05-30
NCT04911907 (ASCO2025)	临床2期	食管癌 \| 胃癌一线 HER2 negative	47	Utidelone + Sintilimab + Oxaliplatin	網壓鹹鏇築構鑰糧製鹽(繭鬱膚築築齋網製襯簾) = 蓋鬱繭獵襯蓋顧衊簾鑰願選選觸鹹鏇艱鹽壓艱 (蓋鹹膚夢醖鹽醖齋糧製 ) 更多	积极	2025-05-30
NCT04911907 (ASCO2025)	临床2期	食管癌 \| 胃癌一线 HER2 negative	47	Utidelone + Tislelizumab + Capecitabine	網壓鹹鏇築構鑰糧製鹽(繭鬱膚築築齋網製襯簾) = 顧窪觸淵壓淵壓範醖鑰願選選觸鹹鏇艱鹽壓艱 (蓋鹹膚夢醖鹽醖齋糧製 ) 更多	积极	2025-05-30