This study will examine the effect of a single high dose of psilocybin therapy (30 mg) versus a very low dose (1 mg) as an adjunctive therapy to individuals undergoing standard-of-care buprenorphine treatment for Opioid use disorder (OUD). Effects of adjunctive psilocybin will be determined for longitudinal outcomes of opioid abstinence, compliance with buprenorphine maintenance, quality of life, and mood.

开始日期2027-04-01

申办/合作机构

The Johns Hopkins University

NCT07226232

/ Not yet recruiting临床3期IIT

A Multi-site Randomized Controlled Trial of Psilocybin for Treatment-Resistant Depression (TRD) in Veterans

The purpose of this multi-site randomized controlled trial is to evaluate the efficacy and risks of psilocybin for the treatment of depression in U.S. military Veterans with and without (±) concurrent posttraumatic stress disorder.

开始日期2026-06-01

申办/合作机构

VA Office of Research and Development

NCT07306364

/ Not yet recruiting临床2期IIT

Psilocybin in Chronic Low Back Pain: An Integrative Study of Lab-Based Mechanisms and Real-World Physical Therapy Outcomes

The purpose of this research study is to investigate whether a single administration of psilocybin can improve interoceptive awareness (awareness of bodily sensations) in individuals with chronic low back pain undergoing physical therapy, and whether these improvements are linked to pain relief and better physical therapy outcomes.

开始日期2026-06-01

申办/合作机构

Yale University

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100 项与裸盖菇素相关的临床结果

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100 项与裸盖菇素相关的转化医学

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100 项与裸盖菇素相关的专利（医药）

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2,333

项与裸盖菇素相关的文献（医药）

2026-03-01·JOURNAL OF AFFECTIVE DISORDERS

Breaking the chains of depression: A systematic review and meta-analysis of psilocybin therapy

Review

作者: Pandupuspitasari, Nuruliarizki Shinta ; Chuchawankul, Siriporn ; Khan, Faheem Ahmed ; Tencomnao, Tewin

Psilocybin, a naturally occurring hallucinogenic substance present in certain mushrooms, has drawn growing attention as a therapeutic breakthrough for several mental and psychiatric conditions. Psilocybin originated in spiritual and cultural traditions and has become the focus of extensive scientific research. This meta-analysis and systematic review aggregate results from the literature to evaluate the therapeutic function of psilocybin following PRISMA 2020. Although it is now used to treat addiction, end-of-life anxiety, and treatment-resistant depression, new research indicates that it could additionally be used to treat obsessive-compulsive disorder, eating disorders, and neurodegenerative diseases. Psilocybin's regulation of serotonin 5-HT2A receptors, which improves neuroplasticity, disrupts maladaptive cognitive processes and encourages emotional integration, is the backend of its therapeutic benefits. The meta-analysis results indicate that psilocybin has an outstanding capacity to reduce the symptoms of anxiety/MDD (SMD = -1.438, 95 % CI: -1.729 to -1.146, p < 0.001) and mood disorders (SMD = -1.476, 95 % CI: -1.773 to -1.178, p < 0.001). Sustained improvements are frequently observed after a single therapy session. The results of this meta-analysis and systematic review highlight psilocybin's potential as a potent and immediate treatment for mental health issues that are difficult to treat. Although the results are resistant to publication bias (fail-safe N > 5500), they highlight the significance of addressing unsolved hurdles to clinical adoption and customizing therapies for particular groups. Psilocybin has the potential to transform psychiatry and give millions of people suffering from crippling mood disorders fresh hope as research progresses and regulations change.

2026-03-01·METABOLIC ENGINEERING

Engineering artificial biosynthetic pathways for efficient microbial production of psilocybin and psilocin

Article

作者: Yan, Yajun ; Adwer, Maryem M ; Luu, Nguyen N T ; Hosseinzadeh, Hemen ; Lin, Yuheng ; Balan, Venkatesh ; Guo, Cui

Psychedelic-assisted therapy is emerging as a highly promising approach for treating depression, with psilocybin, a psychoactive compound in magic mushrooms, gaining the most recognition for its efficacy in treating post-traumatic stress disorder and treatment-resistant depression. However, its low natural abundance makes extraction costly, necessitating alternative production methods. While engineered microbial production has been explored, dependence on the CYP450 hydroxylase (PsiH) in the natural biosynthetic pathway remains a major bottleneck, limiting production efficiency. Here, we report the design, validation, and optimization of non-natural biosynthetic pathways in Escherichia coli that bypass PsiH, enabling efficient psilocybin and psilocin production. De novo biosynthesis of psilocybin achieved record titers of 557.91 mg/L in shake flasks and 2.00 g/L in a bioreactor, outperforming previous microbial engineering efforts. This work demonstrates the great commercial potential of microbial psilocybin production via combinatorial metabolic engineering and synthetic biology approaches.

2026-02-01·NEUROPHARMACOLOGY

Cognitive and subjective effects of psilocybin microdosing: Results from two double-blind placebo-controlled longitudinal trials

Article

作者: Prochazkova, Luisa ; Schon, Neil R ; Hommel, Bernhard ; Lippelt, Dominique Patrick ; Kuchař, Martin ; Marschall, Josephine

OBJECTIVE:

Microdosing psychedelics has been widely reported to enhance focus and problem-solving, sparking interest in its potential to treat attentional disorders such as ADHD. However, existing studies largely rely on anecdotal evidence and lack adequate placebo control.

METHODS:

This study contributes to the literature by examining the longitudinal effects of microdosing psilocybin truffles in two randomized, double-blind, placebo-controlled trials conducted in semi-naturalistic settings. We assessed multiple domains, including cognitive control, memory, social cognition, subjective well-being and subjective experiences using a mix of quantitative and qualitative methods.

RESULTS:

Contrary to expectations, microdosing did not significantly affect behavioral or subjective measures compared to placebo. While some initial effects were observed in social cognition, mood, and self-reported cognitive flexibility, these did not remain significant after correcting for multiple comparisons. Regardless of condition, participants predominantly reported their subjective experiences as positive yet negative bodily feelings were enhanced in the active condition. Notably, participants remained effectively blinded throughout the trials.

DISCUSSION:

In conclusion, our findings do not support the idea that microdosing psilocybin reliably enhances cognitive or emotional functioning beyond placebo. Future research should explore individual differences in response to microdosing and examine whether specific populations might benefit from targeted microdosing interventions.

1,172

项与裸盖菇素相关的新闻（医药）

2026-01-01

·CVDAILY

全球糖尿病速递（第001期）｜单细胞转录组学、Abelmoschus manihot、糖尿病肾病、非编码区变异、脂肪性肝...

*本资料仅供医疗卫生专业人士参考，请勿向非医疗卫生专业人士发放截至01月01日15点59分，近期共有 293 本期刊发布了 930 篇文章，其中糖尿病相关的文章共 312 篇，覆盖 28 个领域的内容。中国专家参与发表的文章有 70 篇。今日，影响因子最高的文章刊登在 iMeta (IF: 33.200) 期刊上。今日头条 Headlines 01 iMeta IF: 33.200 单细胞空间转录组学揭示Abelmoschus manihot (L.) Medic治疗糖尿病肾病的潜在分子机制 Wu, Chenhua, Tang, Haitao, Yu, Yihong, Song, Yuhui, Ge, Haitao, Shen, Yiming, etc. 糖尿病肾病（DKD）作为糖尿病最常见且严重的微血管并发症之一，是全球终末期肾病的主要原因，给患者和社会带来沉重负担。尽管现有治疗策略不断优化，但探索更有效、多靶点的治疗方案仍是医学研究的重要方向。近年来，传统中药在DKD治疗中显示出独特优势，其中源自中药黄蜀葵花（Abelmoschus manihot (L.) Medic）的制剂——黄葵胶囊（HKC）在临床应用中表现出良好的疗效。近日，一项发表于 iMeta 期刊的研究，结合前沿的单细胞空间转录组学技术，深入揭示了黄蜀葵花核心活性成分——总黄酮（TFA）治疗DKD的潜在分子机制。该研究由 Chenhua Wu、Haitao Tang、Harvest F. Gu 等学者共同完成。研究团队以经典的2型糖尿病及DKD动物模型——db/db小鼠为研究对象，将其分为正常对照组、DKD模型组、TFA治疗组以及阳性对照药厄贝沙坦（IRB）治疗组。经过为期四周的干预，研究人员确认，TFA单药治疗能够显著降低db/db小鼠的尿蛋白水平，并有效改善肾脏组织学上的病理损伤，包括肾小球硬化、基底膜增厚和炎性细胞浸润，其疗效与TFA联合IRB或IRB单药治疗相当。为了在空间维度上解析TFA的作用机制，研究采用了高分辨率的空间转录组学技术，成功绘制了db/db小鼠肾脏在疾病状态及药物干预下的单细胞水平空间基因表达图谱。该图谱精准识别并定位了肾脏中包括近端小管细胞、髓袢细胞、集合管主细胞、足细胞、内皮细胞、系膜细胞以及巨噬细胞、T细胞等在内的16种主要细胞类型。通过对空间转录组数据的深度挖掘，研究人员构建了肾脏细胞的转录调控网络。他们发现，在DKD发生发展过程中，一组关键的转录调节因子，如Stat1、Jun、Junb等，在多种肾脏实质细胞和免疫细胞中的活性显著增强。而无论是TFA还是IRB治疗，均能有效抑制这些调节因子的异常活性。进一步追溯其上游，研究发现，这些关键调节因子的活性受到特定细胞表面受体的调控。例如，整合素受体Itgb5的表达在DKD模型的巨噬细胞和集合管主细胞中升高，而TFA和IRB治疗可使其表达下调。分子对接模拟分析提示，TFA中的活性成分槲皮素可能与Itgb5结合，进而抑制其下游的Stat1信号通路。同时，TFA中的多种黄酮类成分可能共同作用于转化生长因子-β受体Tgfbr1，抑制其介导的促纤维化信号。该研究从单细胞空间分辨率的视角，系统描绘了TFA干预DKD的分子图谱，揭示了其通过调控Itgb5-Stat1、Tgfbr1等关键受体-调节因子轴，减轻肾脏免疫炎症反应和纤维化进程，从而发挥肾脏保护作用的潜在机制。这些发现为阐明中药黄蜀葵花治疗糖尿病肾病的现代科学内涵提供了重要的实验依据，也为未来开发多靶点抗DKD药物提供了新的思路和靶点。本文由天纳乾坤编辑扫描二维码查看源文 iMeta | Volume 4, Issue 6 10.1002/imt2.70099 02 Nature methods IF: 32.100 cellSTAAR：整合单细胞测序功能数据以增强非编码区罕见变异关联检验效力 Van Buren, Eric, Zhang, Yi, Li, Xihao, Selvaraj, Margaret Sunitha, Li, Zilin, Zhou, Hufeng, etc. 近日，一项发表于 Nature methods 的研究介绍了一种名为cellSTAAR的创新分析方法，该方法旨在破解非编码区罕见遗传变异影响复杂性状的难题。该研究由 Eric Van Buren、Yi Zhang、Xihao Li 等来自多所研究机构的众多学者共同完成。理解罕见遗传变异如何影响如血脂水平等复杂性状，是现代遗传学面临的主要挑战之一，尤其当这些变异位于基因组的非编码区域时。这些位于候选顺式调控元件内的变异，其效应常常因细胞类型而异，这为解读工作带来了巨大困难。为此，研究者开发了cellSTAAR。 cellSTAAR的核心在于数据整合与策略创新。该方法将大规模人群的全基因组测序数据，与能够揭示染色质可及性在不同细胞类型中差异的单细胞ATAC测序数据相结合。通过这种整合，cellSTAAR能够构建出细胞类型特异性的功能注释和调控元件图谱。更重要的是，为了应对cCREs（候选顺式调控元件）与靶基因之间关联的不确定性，该方法采用了一套综合性的策略来链接cCREs与其可能调控的基因，从而更全面地捕捉潜在的基因调控网络。为了验证cellSTAAR的效力，研究团队将其应用于两个大型人群队列。首先，他们在Trans-Omics for Precision Medicine联盟约60,000人的数据中进行了分析。随后，为了确保结果的可靠性，他们在规模更大的UK Biobank约190,000人的数据中进行了独立验证。研究的焦点集中在四种重要的血脂性状上。分析结果表明，与不整合细胞类型特异性信息的方法相比，cellSTAAR显著提升了对非编码区罕见变异与血脂性状关联的检测能力。更重要的是，该方法发现的关联信号具有更强的生物学可解释性，能够更清晰地指向特定细胞类型中可能受影响的调控通路。这些发现证明，在基于全基因组测序的罕见变异关联研究中，采用这种细胞类型感知的策略，可以有效推动新发现并加深我们对复杂性状遗传基础的理解。本文由天纳乾坤编辑扫描二维码查看源文 Nature methods | Ahead of Print. 10.1038/s41592-025-02919-5 03 Gut : IF: 25.800 代谢功能障碍相关脂肪性肝炎的联合疗法：挑战与机遇 Zhou, Xiao-Dong, Fan, Qiong-Yue, Byrne, Christopher D, Targher, Giovanni, Muthiah, Mark D, Huang, Daniel Q, etc. 近日，一篇发表于《Gut》期刊的综述文章《Combination therapies for metabolic dysfunction-associated steatohepatitis: challenges and opportunities》深入探讨了针对代谢功能障碍相关脂肪性肝炎（MASH）的联合治疗策略。MASH作为一种与肥胖、胰岛素抵抗等心脏代谢共病密切相关的复杂肝病，其治疗正面临从单药到多药联合的范式转变。该文章指出，由于MASH发病机制涉及多条通路，传统的单药治疗往往只能带来肝脏纤维化和全身代谢参数的部分改善，疗效有限。这促使研究人员和临床医生将目光投向了能够同时作用于多个互补靶点的联合疗法。文章强调，这种多靶点策略旨在通过协同作用，达到比任何单一药物更优的治疗效果。具体而言，联合疗法可以从不同维度设计。一类是专注于肝脏本身的“肝脏导向”组合，例如将甲状腺激素受体-β（THR-β）激动剂与乙酰辅酶A羧化酶（ACC）抑制剂或过氧化物酶体增殖物激活受体（PPAR）激动剂联用，其主要目标是更有效地改善肝脏脂肪变性、炎症和纤维化等核心组织学病变。另一类策略则将改善全身代谢状态与针对肝脏的特异性作用结合起来。例如，胰高血糖素样肽-1（GLP-1）受体激动剂在有效降低体重、改善血糖的同时，若与成纤维细胞生长因子-21（FGF-21）类似物或THR-β激动剂联合，有望实现对肝脏和全身代谢指标的双重优化，为患者带来更全面的健康获益。值得注意的是，联合用药还可能解决单药治疗中的安全性瓶颈。文章提到，一些经过深思熟虑的药物配对能够利用其机制的互补性来抵消彼此潜在的副作用。例如，二酰基甘油O-酰基转移酶2（DGAT2）抑制剂与ACC抑制剂的组合，或者GLP-1/胰高血糖素双重受体激动剂，其设计初衷之一就是提高整体的安全性和患者的耐受性。这篇综述系统地整合了该领域的最新知识，不仅阐述了各种联合方案的生物学原理，也审视了正在涌现的临床证据。作者团队由Zhou Xiao-Dong、Fan Qiong-Yue、Byrne Christopher D、Targher Giovanni、Muthiah Mark D、Huang Daniel Q、Chen Qin-Fen、Noureddin Mazen、Li Wenhao、Ratziu Vlad、Loomba Rohit、Francque Sven M、Sanyal Arun J和Zheng Ming-Hua等多位国际肝病与代谢领域专家组成。文章最后指出，合理设计并实施联合疗法是未来MASH管理的重要方向。其最终目标是超越单药治疗的局限，为患者提供在肝脏病理逆转和全身代谢健康改善方面更强大、更持久的解决方案。这为临床医生和研究者提供了一个优化MASH个体化治疗的综合性框架。本文由天纳乾坤编辑扫描二维码查看源文 Gut : | Ahead of Print. 10.1136/gutjnl-2025-337431 中国发表（70） China Eur J Med Res IF: 03.400Ahead of Print.No.01Sex-specific differences in the prognostic value of METS-IR for long-term outcomes in patients with MASLD and advanced liver fibrosis: a nationwide studyMETS-IR对MASLD合并晚期肝纤维化患者长期预后的预测价值存在性别差异：一项全国性研究DOI: 10.1186/s40001-025-03783-x Comp Biochem Physiol Part D Genomics Proteomics IF: 02.400Ahead of Print.No.02Comparative transcriptomics identifies key genes and pathways underlying the early skin coloration in leopard coral grouper (Plectropomus leopardus)比较转录组学揭示豹纹珊瑚鳟早期皮肤着色的关键基因与通路DOI: 10.1016/j.cbd.2025.101736 Eur J Med Res IF: 03.400Ahead of Print.No.03Triglyceride glucose index and atherogenic index of plasma predict rapid kidney function decline in cardiovascular-kidney-metabolic syndrome: the first longitudinal evidence from CHARLS甘油三酯-葡萄糖指数与血浆致动脉粥样硬化指数预测心血管-肾脏-代谢综合征患者的肾功能快速下降：来自CHARLS的一项纵向研究证据DOI: 10.1186/s40001-025-03751-5 BMJ open IF: 02.300Volume 15, Issue 12No.04Association between the cumulative average triglyceride glucose-body mass index and glycaemic state transitions in adults with pre-diabetes: evidence from the CHARLS cohort累积平均甘油三酯葡萄糖-体质量指数与成人糖尿病前期患者血糖状态转变的关联：来自CHARLS队列的证据DOI: 10.1136/bmjopen-2025-099014 BMC endocrine disorders IF: 03.300Ahead of Print.No.05New sights of tumor-specific growth factor (TSGF) in T2DM patients with coronary artery disease2型糖尿病合并冠状动脉疾病患者中肿瘤特异性生长因子（TSGF）的新见解DOI: 10.1186/s12902-025-02152-3 Journal of Advanced Research IF: 13.000Ahead of Print.No.06Plasma apolipoprotein E protein attenuates pulmonary fibrosis through LRP1 and PLAU dual receptor-mediated TGF-β/Smad inhibition血浆载脂蛋白E蛋白通过LRP1和PLAU双受体介导的TGF-β/Smad抑制减轻肺纤维化DOI: 10.1016/j.jare.2025.12.045 Journal of controlled release IF: 11.500Ahead of Print.No.07Local cochlear delivery of berberine chloride hydrate via an injectable photo-crosslinked hydrogel for treating diabetes- induced hearing loss通过可注射光交联水凝胶局部递送盐酸小檗碱治疗糖尿病性听力损失DOI: 10.1016/j.jconrel.2025.114582 Diabetes & metabolic syndrome IF: 03.400Ahead of Print.No.08Efficacy and safety of finerenone in the treatment of primary aldosteronism: A prospective clinical study非奈利酮治疗原发性醛固酮增多症的有效性与安全性：一项前瞻性临床研究DOI: 10.1016/j.dsx.2025.103369 Colloids Surf B Biointerfaces IF: 05.600Ahead of Print.No.09Cascade ROS-modulating Au/Cu nanozyme hydrogel with nitric oxide release ability for accelerated diabetic foot ulcer healing兼具一氧化氮释放能力的级联ROS调节型金/铜纳米酶水凝胶加速糖尿病足溃疡愈合DOI: 10.1016/j.colsurfb.2025.115403 Colloids Surf B Biointerfaces IF: 05.600Ahead of Print.No.10Baicalein-manganese nanoparticles for antioxidant and osteogenic therapy of bone injury黄芩素-锰纳米颗粒用于骨损伤的抗氧化及成骨治疗DOI: 10.1016/j.colsurfb.2025.115400 Ophthalmology retina IF: 05.700Ahead of Print.No.11Timing of Preoperative Anti-VEGF for Vitrectomy in Proliferative Diabetic Retinopathy: A Competing-Risks Analysis of a Large Cohort增生性糖尿病视网膜病变玻璃体切除术术前抗VEGF用药时机：基于大样本队列的竞争风险分析DOI: 10.1016/j.oret.2025.12.019 Experimental Eye Research IF: 02.700Ahead of Print.No.12Age-related Alterations in Retinal Structure and Blood Perfusion in TIPE2 Gene-Knockout MiceTIPE2基因敲除小鼠视网膜结构与血液灌注的年龄相关改变DOI: 10.1016/j.exer.2025.110834 Gut : IF: 25.800Ahead of Print.No.13Combination therapies for metabolic dysfunction-associated steatohepatitis: challenges and opportunities代谢功能障碍相关脂肪性肝炎的联合疗法：挑战与机遇DOI: 10.1136/gutjnl-2025-337431 Carbohydrate polymers IF: 12.500Volume 375, Issue No.14Structural characterization and lipid-modulating effects of an inulin-type fructan from Bacillus amyloliquefaciens D189: Unraveling the microbiota-gut-liver axis解淀粉芽孢杆菌D189来源的菊粉型果聚糖的结构表征与脂质调节作用：揭示微生物-肠-肝轴机制DOI: 10.1016/j.carbpol.2025.124809 Carbohydrate polymers IF: 12.500Volume 375, Issue No.15Chitosan/selenium nanoparticles Pickering emulsion prolong quercetin retention time to ameliorates cognitive disorder: Focus on restoring the metabolic disorder and gut microbiota壳聚糖/硒纳米颗粒Pickering乳液通过延长槲皮素保留时间改善认知障碍：聚焦于恢复代谢紊乱与肠道菌群DOI: 10.1016/j.carbpol.2025.124804 Carbohydrate polymers IF: 12.500Volume 375, Issue No.16Chitosan and chito-oligosaccharides as multifunctional therapeutics for metabolic dysfunction-associated steatotic liver disease (MASLD)壳聚糖与壳寡糖作为代谢相关脂肪性肝病的多功能疗法DOI: 10.1016/j.carbpol.2025.124737 Journal of affective disorders IF: 04.900Ahead of Print.No.17Sex differences in prevalence of subclinical hypothyroidism and its clinical correlates in overweight or obese, first-episode drug-naïve Chinese patients with major depressive disorder中国超重或肥胖、首次发作未用药重性抑郁障碍患者中亚临床甲状腺功能减退症的患病率及临床相关因素的性别差异DOI: 10.1016/j.jad.2025.121068 Annals of medicine IF: 04.300Volume 58, Issue 1No.18Zinc status following different bariatric procedures: systematic review and meta-analysis不同减重手术后锌水平的系统评价与Meta分析DOI: 10.1080/07853890.2025.2608532 Nutrition IF: 03.000Ahead of Print.No.19Estimating resting metabolic rate in older Chinese adults:A community-based study integrating dietary predictors老年中国人群静息代谢率估算：一项整合膳食预测因子的社区研究DOI: 10.1016/j.nut.2025.113054 JMIR aging IF: 04.800Volume 8, Issue No.20Association of Insulin Resistance, Sarcopenia, and Risk of Cardiovascular Disease: Findings From the China Health and Retirement Longitudinal Study胰岛素抵抗、肌肉减少症与心血管疾病风险的关联：基于中国健康与养老追踪调查的发现DOI: 10.2196/80115 The Journal of cell biology IF: 06.400Volume 225, Issue 2No.21In vivo mapping of peroxisome dynamics and pexophagy using PO-TRG and CA-PO-TRG reporter mice使用PO-TRG及CA-PO-TRG报告小鼠进行体内过氧化物酶体动态及过氧化物酶体自噬（Pexophagy）绘图DOI: 10.1083/jcb.202503169 Biomaterials advances IF: 06.000Ahead of Print.No.22Design, fabrication, and evaluation of antimicrobial sponge-hydrogel bilayer microneedles: An integrated system for transdermal insulin delivery and glucose sensing抗菌海绵-水凝胶双层微针的设计、制备与评估：一个用于透皮胰岛素输送与葡萄糖传感的集成系统DOI: 10.1016/j.bioadv.2025.214693 Medical physics IF: 03.200Volume 53, Issue 1No.23Weakly supervised object detection network for diabetic retinopathy弱监督目标检测网络用于糖尿病视网膜病变检测DOI: 10.1002/mp.70264 Frontiers in nutrition IF: 05.100Volume 12, Issue No.24Correction: Diagnostic efficacy of remnant cholesterol inflammatory index in diabetic kidney disease: machine learning approaches更正：残留胆固醇炎症指数在糖尿病肾病中的诊断有效性：机器学习方法DOI: 10.3389/fnut.2025.1755030 iMeta IF: 33.200Volume 4, Issue 6No.25Single-cell spatial transcriptomics reveals potential molecular mechanisms of Abelmoschus manihot (L.) medic in treating diabetic kidney disease单细胞空间转录组学揭示Abelmoschus manihot (L.) Medic治疗糖尿病肾病的潜在分子机制DOI: 10.1002/imt2.70099 Chinese Medical Journal IF: 07.300Ahead of Print.No.26Association of cardiovascular-kidney-metabolic syndrome stages with mortality: A nationwide, population-based, prospective cohort study心血管-肾脏-代谢综合征分期与死亡率的关联：一项全国性、基于人群的前瞻性队列研究DOI: 10.1097/CM9.0000000000003914 IDCases IF: 01.000Volume 42, Issue No.27Silent pulmonary tuberculosis in patients with poorly controlled diabetes mellitus: Pathogenesis, clinical implications, and diagnostic challenges血糖控制不佳糖尿病患者中的隐匿性肺结核：发病机制、临床意义与诊断挑战DOI: 10.1016/j.idcr.2025.e02357 Frontiers in oncology IF: 03.300Volume 15, Issue No.28Poor nutritional status based on controlling nutritional status score and nutritional risk index may be related to the occurrence of complications after laparoscopic treatment in patients with gastrointestinal tumors aged no more than 60 years基于CONUT评分和NRI的营养不良状态可能与60岁及以下的胃肠道肿瘤患者腹腔镜治疗后并发症的发生有关DOI: 10.3389/fonc.2025.1723703 Frontiers in medicine IF: 03.000Volume 12, Issue No.29Analysis of prognostic prediction and nursing intervention value in PD patients based on nomogram model基于列线图模型对腹膜透析患者预后预测及护理干预价值的分析DOI: 10.3389/fmed.2025.1645631 FCVM IF: 02.900Volume 12, Issue No.30SGLT2 inhibitor short-term efficacy and SYNTAX score association in coronary heart disease retinopathy: a propensity score matching studySGLT2抑制剂短期有效性及SYNTAX评分与冠心病视网膜病变的关联：一项倾向性评分匹配研究DOI: 10.3389/fcvm.2025.1651251 Frontiers in immunology IF: 05.900Volume 16, Issue No.31The multifaceted roles and diagnostic-therapeutic potential of LINC01410 in malignant tumors and non-malignant disordersLINC01410在恶性肿瘤及非恶性疾病中的多维角色与诊疗潜力DOI: 10.3389/fimmu.2025.1588816 J Multidiscip Healthc IF: 02.400Volume 18, Issue No.32Impact of Medical-Prevention Integration on Resource Utilization Efficiency in Chronic Disease Management Among Older Adults: Ethical and Economic Perspectives医防融合模式对老年人慢性病管理资源利用效率的影响：伦理与经济视角DOI: 10.2147/JMDH.S564477 Diabetic medicine IF: 03.400Ahead of Print.No.33The exosome-PI3K/Akt-autophagy axis in diabetic vascular complications: Mechanisms and implications糖尿病血管并发症中的外泌体-PI3K/Akt-自噬轴：机制与意义DOI: 10.1111/dme.70196 Biomed Environ Sci IF: 04.100Volume 38, Issue 12No.34The Impacts of Major Chronic Diseases on Changes in Healthy Life Expectancy among Older Adults in China from 2011 to 20202011-2020年中国老年人主要慢性病对健康预期寿命变化的影响DOI: 10.3967/bes2025.064 Oral diseases IF: 02.900Ahead of Print.No.35Exposure to Famine in Early Childhood Increases the Odds of Edentulism in Adulthood: Results From the China Health and Retirement Longitudinal Study童年早期经历饥荒增加成年后无牙症风险：基于中国健康与养老追踪调查的结果DOI: 10.1111/odi.70177 CCI IF: 01.900Ahead of Print.No.36The Radial Artery Occlusion Paradox: The Larger-Bore Sheath via the Thinner Distal Radial Artery for Coronary Interventional Procedures桡动脉闭塞悖论：经远端桡动脉应用大鞘管行冠状动脉介入治疗DOI: 10.1002/ccd.70456 Microorganisms IF: 04.200Volume 13, Issue 12No.37Alterations in Gut Microbial Co-Abundance Networks in Metabolic Syndrome: A Population-Based Cross-Sectional Study代谢综合征患者肠道微生物共丰度网络的改变：一项基于人群的横断面研究DOI: 10.3390/microorganisms13122759 Ann Agric Environ Med IF: 01.200Volume 32, Issue 4No.38Association between obesity and non-alcoholic fatty liver disease (NAFLD) in adults aged 18 years and above - data from NHANES 2017-201818岁及以上成人中肥胖与非酒精性脂肪性肝病的关联——基于NHANES 2017-2018数据DOI: 10.26444/aaem/210489 Biomed Environ Sci IF: 04.100Volume 38, Issue 12No.39Anthropometric Obesity Measures and Diabetes Progression from Prediabetes in Older Adults: A Comparison of American Diabetes Association and World Health Organization Criteria老年人体质指数及腰围测量与糖尿病前期向糖尿病进展的关系：美国糖尿病协会与世界卫生组织诊断标准的比较DOI: 10.3967/bes2025.090 Biomed Environ Sci IF: 04.100Volume 38, Issue 12No.40Association of Frailty with Mortality and Incident Cardiovascular Disease: The Role of Metabolic Status衰弱与死亡和心血管疾病发病风险的关联：代谢状态的作用DOI: 10.3967/bes2025.154 Biomed Environ Sci IF: 04.100Volume 38, Issue 12No.41Excess Body Weight and Its Influence on Colonoscopy Adherence and Findings: Results from an Opportunistic Colorectal Cancer Screening Program in Chongqing超重对结肠镜筛查依从性及病变检出的影响：来自重庆机会性结直肠癌筛查项目的结果DOI: 10.3967/bes2025.153 Biomed Environ Sci IF: 04.100Volume 38, Issue 12No.42Health Determinants in Association with Cancer Mortality from a Health Ecological Perspective健康生态视角下健康决定因素与癌症死亡率的关系DOI: 10.3967/bes2025.152 Biomed Environ Sci IF: 04.100Volume 38, Issue 12No.43Tackling Adult Obesity in China: A Time for Action应对中国成人肥胖症：行动之时DOI: 10.3967/bes2025.149 Nutrients IF: 05.000Volume 17, Issue 24No.44Hyodeoxycholic Acid Suppresses High-Fat-Diet-Promoted MC38-Syngeneic Colorectal Tumor Growth via Bile Acid Remodeling and Microbiota Modulation猪去氧胆酸通过胆汁酸重塑和肠道菌群调节抑制高脂饮食促进的MC38同源结直肠肿瘤生长DOI: 10.3390/nu17243939 Nutrients IF: 05.000Volume 17, Issue 24No.45Soluble Dietary Fiber from Highland Barley Bran Reduces Hepatic Lipid Accumulation in Mice via Gut Microbiota Modulation青稞麸皮可溶性膳食纤维通过调控肠道菌群减少小鼠肝脏脂质积累DOI: 10.3390/nu17243870 Population health metrics IF: 02.500Ahead of Print.No.46Association of loneliness and social isolation with excess risk of mental disorders in people with obesity: a prospective cohort study肥胖人群中孤独与社交隔离与精神障碍超额风险的关联：一项前瞻性队列研究DOI: 10.1186/s12963-025-00451-4 Frontiers in endocrinology IF: 04.600Volume 16, Issue No.47Development and external validation of machine-learning based models to predict diabetic foot ulcer in diabetes population基于机器学习的糖尿病足溃疡预测模型的开发与外部验证DOI: 10.3389/fendo.2025.1692917 Frontiers in endocrinology IF: 04.600Volume 16, Issue No.48Exploring the mechanism of Heidihuang Pill in the treatment of osteoporosis based on network pharmacology, molecular docking, and experimental validation基于网络药理学、分子对接及实验验证探讨黑地黄丸治疗骨质疏松的作用机制DOI: 10.3389/fendo.2025.1664254 Journal of nanobiotechnology IF: 12.600Ahead of Print.No.49Biomimetic cell membrane decorated calcium carbonate nanoparticles with asparaginase-metformin preloading for leukemia therapy载有天冬酰胺酶-二甲双胍的仿生细胞膜修饰碳酸钙纳米颗粒用于白血病治疗DOI: 10.1186/s12951-025-03962-2 Frontiers in neurology IF: 02.800Volume 16, Issue No.50Comparative impact of different weight loss strategies on obstructive sleep apnea: an integrated review of surgical, pharmacological, and lifestyle interventions不同减肥策略对阻塞性睡眠呼吸暂停影响的比较综述：手术、药物和生活方式干预DOI: 10.3389/fneur.2025.1719923 Molecules IF: 04.600Volume 30, Issue 24No.51Discovery and Activity Evaluation of Novel Dibenzoxazepinone Derivatives as Glycogen Phosphorylase Inhibitors新型二苯并氧氮杂䓬酮衍生物作为糖原磷酸化酶抑制剂的发现与活性评价DOI: 10.3390/molecules30244797 Molecules IF: 04.600Volume 30, Issue 24No.52Isolation, Total Synthesis and Anti-Diabetic Activity of Filiforidine from Cassytha filiformis从无根藤中分离、全合成菲力福里定及其抗糖尿病活性研究DOI: 10.3390/molecules30244763 Nutrients IF: 05.000Volume 17, Issue 24No.53Impact of the Mediterranean Diet on Glycemic Control, Body Mass Index, Lipid Profile, and Blood Pressure in Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials地中海饮食对2型糖尿病患者血糖控制、体重指数、血脂谱及血压影响的荟萃分析DOI: 10.3390/nu17243908 Frontiers in medicine IF: 03.000Volume 12, Issue No.54The impact of short-term administration of dapagliflozin on contrast-induced acute kidney injury in patients with type 2 diabetes and renal insufficiency undergoing percutaneous coronary intervention短期应用达格列净对合并肾功能不全的2型糖尿病患者经皮冠状动脉介入治疗后造影剂急性肾损伤的影响DOI: 10.3389/fmed.2025.1744473 J Clin Transl Hepatol IF: 04.200Volume 13, Issue 12No.55Quality and Quantity? The Clinical Significance of Myosteatosis in Various Liver Diseases: A Narrative Review质量还是数量？肌脂变在各种肝病中的临床意义：一篇叙述性综述DOI: 10.14218/JCTH.2025.00383 Frontiers in endocrinology IF: 04.600Volume 16, Issue No.56Effects of fecal microbiota transplantation on glycemic and lipid profiles in overweight or obese patients with metabolic disorders: a systematic review and meta-analysis粪菌移植对超重或肥胖代谢紊乱患者血糖及血脂谱影响：一项系统评价与荟萃分析DOI: 10.3389/fendo.2025.1737543 Frontiers in microbiology IF: 04.500Volume 16, Issue No.57Gut microbiome associated with melanin deposition by supporting energy metabolism in Sichuan mountainous black-bone chickens肠道微生物组通过支持能量代谢影响四川山地乌骨鸡的黑色素沉积DOI: 10.3389/fmicb.2025.1682376 Microorganisms IF: 04.200Volume 13, Issue 12No.58Shared Gut Microbial and Functional Signatures Linking Parkinson's Disease and Type 2 Diabetes Revealed by Function-Anchored Metagenomics基于功能锚定的宏基因组学揭示连接帕金森病与2型糖尿病的共享肠道微生物及功能特征DOI: 10.3390/microorganisms13122705 Molecules IF: 04.600Volume 30, Issue 24No.59First In Vitro Human Islet Assessment of Oleanolic Acid (OA) and Its Serine Conjugate: Enhanced Solubility with Comparable Effects齐墩果酸及其丝氨酸结合物的首次体外人类胰岛评估：溶解性增强且效果相当DOI: 10.3390/molecules30244716 Pharmaceuticals IF: 04.800Volume 18, Issue 12No.60Berberine: A Rising Star in the Management of Type 2 Diabetes-Novel Insights into Its Anti-Inflammatory, Metabolic, and Epigenetic Mechanisms小檗碱：2型糖尿病管理中的一颗新星——其抗炎、代谢与表观遗传机制的新见解DOI: 10.3390/ph18121890 Pharmaceuticals IF: 04.800Volume 18, Issue 12No.61Emodin Enhances Rosiglitazone's Therapeutic Profile by Dual Modulation of SREBP1-Mediated Adipogenesis and PPARγ-Driven Thermogenesis大黄素通过双重调节SREBP1介导的脂肪生成与PPARγ驱动的产热作用增强罗格列酮的治疗谱DOI: 10.3390/ph18121810 Pharmaceutics IF: 05.500Volume 17, Issue 12No.62The Detrimental Effects of Crystalline Excipients: How They Jeopardize the Long-Term Stability of Freeze-Dried Polypeptide Formulations结晶性辅料的不利影响：它们如何损害冻干多肽制剂的长期稳定性DOI: 10.3390/pharmaceutics17121543 Nutrients IF: 05.000Volume 17, Issue 24No.63European Bilberry Extract Ameliorates Dietary Advanced Glycation End Products-Induced Non-Alcoholic Steatohepatitis in Rats via Gut Microbiota and Its Metabolites欧洲越橘提取物通过肠道菌群及其代谢物改善饮食晚期糖基化终末产物诱导的大鼠非酒精性脂肪性肝炎DOI: 10.3390/nu17243918 Nutrients IF: 05.000Volume 17, Issue 24No.64Milk Powder Fortified with Folic Acid and Colostrum Basic Protein Promotes Linear Growth and Improves Bone Microarchitecture in Juvenile Mice Without Adverse Metabolic Effects添加叶酸和初乳碱性蛋白的奶粉促进幼年小鼠线性生长并改善骨微结构，且无不良代谢影响DOI: 10.3390/nu17243819 Frontiers in endocrinology IF: 04.600Volume 16, Issue No.65Comparison of different insulin resistance surrogates in predicting hyperuricemia in non-diabetic Yi residents in Yunnan Province云南非糖尿病人群中不同胰岛素抵抗替代指标预测高尿酸血症能力的比较DOI: 10.3389/fendo.2025.1523771 Int J Gen Med IF: 02.000Volume 18, Issue No.66Correlation Between Triglyceride-Glucose Index (TyG Index), Monocyte to High-Density Lipoprotein Cholesterol Ratio (MHR), and the Severity of Coronary Artery Disease甘油三酯-葡萄糖指数（TyG指数）、单核细胞与高密度脂蛋白胆固醇比值（MHR）与冠状动脉疾病严重程度的相关性DOI: 10.2147/IJGM.S570395 Lipids in health and disease IF: 04.200Ahead of Print.No.67Comparison of the TyG index, TyG-traditional obesity indices, and TyG-novel obesity indices: does increased complexity help in predicting cardiometabolic multimorbidity?比较TyG指数、TyG-传统肥胖指数与TyG-新型肥胖指数：增加复杂性有助于预测心脏代谢多病吗？DOI: 10.1186/s12944-025-02836-8 Nutrients IF: 05.000Volume 17, Issue 24No.68Pioneering Insights into the Complexities of Salt-Sensitive Hypertension: Central Nervous System Mechanisms and Dietary Bioactive Compound Interventions盐敏感性高血压的复杂机制探索：中枢神经系统通路与膳食生物活性化合物干预的新见解DOI: 10.3390/nu17243961 FCVM IF: 02.900Volume 12, Issue No.69Effects of subcutaneous or oral semaglutide on cardiovascular outcomes in patients with type 2 diabetes mellitus: a meta-analysis of randomized controlled trials皮下或口服司美格鲁肽对2型糖尿病患者心血管结局的影响：随机对照试验的荟萃分析DOI: 10.3389/fcvm.2025.1731127 J Transl Med IF: 07.500Volume 23, Issue 1No.70Comment on: "Identification of macrophage polarisation and mitochondrial-related biomarkers in diabetic retinopathy"糖尿病视网膜病变中巨噬细胞极化及线粒体相关生物标志物的识别DOI: 10.1186/s12967-025-07457-4 其他发布内容（241） More Published Articles Legal medicine IF: 01.400Ahead of Print.No.01Application of RNA sequencing to cause-of-death investigation: A pilot studyRNA测序在死因调查中的应用：一项初步研究DOI: 10.1016/j.legalmed.2025.102772 Scientific reports IF: 03.900Ahead of Print.No.02Understanding the mechanism of Crassocephalum crepidiodes (Benth.) S. Moore leaf antifibrotic activity using in vivo and in silico methods基于体内外方法探究Crassocephalum crepidiodes (Benth.) S. Moore叶抗纤维化活性的机制DOI: 10.1038/s41598-025-34489-z Virology journal IF: 03.800Ahead of Print.No.03SGLT2 inhibitors prevent long-COVID-associated cognitive and pain symptoms in type 2 diabetes patientsSGLT2抑制剂预防2型糖尿病患者长期COVID相关的认知和疼痛症状DOI: 10.1186/s12985-025-03054-5 Scientific reports IF: 03.900Ahead of Print.No.04Analysis of proteins and peptides to investigate the molecular signatures of a conventional antidiabetic herb, Boerhavia procumbens Banks ex Roxb. (Nyctaginaceae)通过分析蛋白质与肽段探究传统抗糖尿病草药Boerhavia procumbens Banks ex Roxb. (Nyctaginaceae)的分子特征DOI: 10.1038/s41598-025-16474-8 BMJ case reports IF: 00.500Volume 18, Issue 12No.05Concurrent hepatic adenomatosis and hemangiomatosis in a patient with HNF1A MODYHNF1A MODY患者并发肝腺瘤病与血管瘤病DOI: 10.1136/bcr-2025-269815 BMJ case reports IF: 00.500Volume 18, Issue 12No.06Miliary tuberculosis with hypercalcaemia-induced nephrogenic diabetes insipidus in an infant婴儿粟粒性结核伴高钙血症诱发肾性尿崩症DOI: 10.1136/bcr-2025-269609 BMJ open IF: 02.300Volume 15, Issue 12No.07Implementation of the community health system innovation project in three low- and middle-income countries: COHESION-I study protocol社区健康系统创新项目在三个低收入和中等收入国家的实施：COHESION-I研究方案DOI: 10.1136/bmjopen-2025-109433 Endocrine practice IF: 04.600Ahead of Print.No.08LOW VASOPRESSIN IN MYALGIC ENCEPHALOMYELITIS/CHRONIC FATIGUE SYNDROME肌痛性脑脊髓炎/慢性疲劳综合征中的低血管加压素水平DOI: 10.1016/j.eprac.2025.12.020 J Biomed Inform IF: 04.500Ahead of Print.No.09Integrating retrospective quality assessment with real-time guideline application to support the episodic application of clinical guidelines over significant time periods集成回顾性质控与实时指南应用以支持临床指南在较长时间内的阶段性应用DOI: 10.1016/j.jbi.2025.104975 Journal of affective disorders IF: 04.900Ahead of Print.No.10Weight control methods and risk of generalized anxiety disorder (GAD-7) among Korean adults韩国成人减肥方法与广泛性焦虑障碍（GAD-7）风险的关系DOI: 10.1016/j.jad.2025.121071 Am J Clin Nutr IF: 06.900Ahead of Print.No.11Consuming an unprocessed diet reduces energy intake: A post-hoc analysis of an RCT reveals a role for human 'nutritional intelligence'摄入非加工饮食可减少能量摄入：一项随机对照试验的事后分析揭示人类“营养智能”的作用DOI: 10.1016/j.ajcnut.2025.101183 Canadian journal of diabetes IF: 02.600Ahead of Print.No.12Evaluating virtual care for diabetes during the COVID-19 pandemic: results from a pre-post retrospective cohort pilot study in a Canadian family health teamCOVID-19大流行期间糖尿病虚拟护理评估：一项加拿大家庭健康团队预-后回顾性队列试点研究结果DOI: 10.1016/j.jcjd.2025.12.010 Canadian journal of diabetes IF: 02.600Ahead of Print.No.13Diabetes Self-Care in Daily Life: a Qualitative Study on Goal Conflict Management in Emerging Adults With Type 1 Diabetes1型糖尿病年轻成人的日常自我管理：关于目标冲突管理的定性研究DOI: 10.1016/j.jcjd.2025.12.011 Psychiatry research IF: 03.900Ahead of Print.No.14Metabolic monitoring and control among patients with type 2 diabetes prescribed second generation antipsychotics接受第二代抗精神病药物治疗的2型糖尿病患者的代谢监测与控制DOI: 10.1016/j.psychres.2025.116925 Placenta IF: 02.500Ahead of Print.No.15Exploring the role of specialized pro-resolving mediators, fatty acid oxidation markers and transporters in Gestational Diabetes Mellitus (GDM) placentae探究特异性促消退介质、脂肪酸氧化标志物及转运蛋白在妊娠期糖尿病胎盘中的作用DOI: 10.1016/j.placenta.2025.12.014 Sleep medicine IF: 03.400Ahead of Print.No.16Exploring sleep outcomes in youth across settings: Are there differences based on rurality or medically underserved status in the ECHO cohort?探索不同环境下青少年的睡眠状况：基于农村或医疗服务不足状况在ECHO队列中是否存在差异？DOI: 10.1016/j.sleep.2025.108754 Tissue & cell IF: 02.500Ahead of Print.No.17Vitreous exosomes and ocular regeneration: Emerging roles in intercellular communication, biomarkers, and therapeutic delivery玻璃体外泌体与眼再生：细胞间通讯、生物标志物及治疗递送中的新兴作用DOI: 10.1016/j.tice.2025.103300 Ophthalmology IF: 09.500Ahead of Print.No.18Cardiovascular Risk and Eye Health: A Prospective Cohort Study of the Pooled Cohort Equations and Ocular Disease Incidence心血管风险与眼部健康：一项关于汇总队列方程与眼部疾病发病率的前瞻性队列研究DOI: 10.1016/j.ophtha.2025.12.021 J Diabetes Complications IF: 03.100Ahead of Print.No.19Effects of high estimated glomerular filtration rate on kidney prognosis in individuals with type 2 diabetes高估测肾小球滤过率对2型糖尿病患者肾脏预后的影响DOI: 10.1016/j.jdiacomp.2025.109255 Am J Ophthalmol IF: 04.200Ahead of Print.No.20Comment on: Glucagon-like Peptide-1 Receptor Agonist Use and Risk of Cataract Development评论：胰高血糖素样肽-1受体激动剂使用与白内障发生风险DOI: 10.1016/j.ajo.2025.11.050 Biology of sex differences IF: 05.100Ahead of Print.No.21Hormones, heat, and health: a comprehensive review of sex-based differences in brown and beige fat biology激素、热量与健康：棕色脂肪与米色脂肪生物学中基于性别差异的全面评述DOI: 10.1186/s13293-025-00787-4 Nature communications IF: 15.700Ahead of Print.No.22Phosphoproteomics of aged insulin-resistant bone identifies P70S6K phosphorylation of AFF4 as a gene-specific transcriptional regulator老年胰岛素抵抗骨骼的磷酸蛋白质组学鉴定出P70S6K对AFF4的磷酸化是一种基因特异性转录调节因子DOI: 10.1038/s41467-025-68106-4 Surg Obes Relat Dis IF: 03.800Ahead of Print.No.23The impact of hospital volume on metabolic and bariatric surgery outcomes医院手术量对代谢与减重手术结果的影响DOI: 10.1016/j.soard.2025.11.023 BMJ case reports IF: 00.500Volume 18, Issue 12No.24Delayed retrograde jejunogastric intussusception after Roux-en-Y gastrojejunostomy: an uncommon complication in an unexpected anatomyRoux-en-Y胃空肠吻合术后迟发性逆行性空肠胃套叠：一种意外解剖结构中的罕见并发症DOI: 10.1136/bcr-2025-268432 BMJ open IF: 02.300Volume 15, Issue 12No.25Impact of food accessibility on eating and anthropometric outcomes among rural parent-child dyads: a secondary data analysis of a mindful eating intervention食物可及性对农村亲子对的饮食行为和人体测量学结果的影响：一项正念饮食干预的二次数据分析DOI: 10.1136/bmjopen-2025-108076 Am J Clin Nutr IF: 06.900Ahead of Print.No.26Diet quality and nutritional adequacy during a 2-year calorie restriction intervention: the CALERIE™ 2 trial为期两年的热量限制干预期间的饮食质量与营养充足性：CALERIE™ 2试验DOI: 10.1016/j.ajcnut.2025.101182 Ophthalmology IF: 09.500Ahead of Print.No.27Rate and risk of non-arteritic anterior ischaemic optic neuropathy with semaglutide use for diabetes and weight loss: a systematic review and meta-analysis司美格鲁肽用于糖尿病和减重时的非动脉炎性前部缺血性视神经病变发生率和风险：一项系统评价与荟萃分析DOI: 10.1016/j.ophtha.2025.12.022 J Sport Health Sci IF: 10.300Ahead of Print.No.28A systematic review and meta-analyses of the relationships between active outdoor play and 24-hour movement behaviors关于主动户外游戏与24小时运动行为关系的系统综述和荟萃分析DOI: 10.1016/j.jshs.2025.101115 Pharmacological research IF: 10.500Ahead of Print.No.29Low, non-psychedelic doses of psilocybin as a novel treatment for MASLD, obesity and Type 2 Diabetes via 5-HT2B receptor-dependent mechanisms低剂量、非致幻的赛洛西宾通过5-HT2B受体依赖机制成为治疗MASLD、肥胖和2型糖尿病的新方法DOI: 10.1016/j.phrs.2025.108080 J Nutr Biochem IF: 04.900Ahead of Print.No.30Complementary mechanisms of high-carbohydrate diets and ketogenic diets restore adult hippocampal neurogenesis and cognitive function in high-fat diet induced obesity in mice高碳水化合物饮食与生酮饮食通过互补机制恢复高脂饮食诱导的肥胖小鼠成年海马神经发生与认知功能DOI: 10.1016/j.jnutbio.2025.110245 Clinical nutrition ESPEN IF: 02.600Ahead of Print.No.31BODY COMPOSITION AND FUNCTIONAL STATUS IN THE COVID-19 RECOVERY PHASE: PREVALENCE OF SARCOPENIA AND SARCOPENIC OBESITYCOVID-19恢复期的身体成分与功能状态：肌肉减少症与肌肉减少性肥胖的患病率DOI: 10.1016/j.clnesp.2025.102877 Clinical nutrition ESPEN IF: 02.600Ahead of Print.No.32Can the (13)C-octanoic acid breath test accurately measure gastric emptying after sleeve gastrectomy and Roux-en-Y gastric bypass? A proof-of concept analysis碳13-辛酸呼气试验能否准确测量袖状胃切除和Roux-en-Y胃旁路术后的胃排空？一项概念验证分析DOI: 10.1016/j.clnesp.2025.102891 Nutrition IF: 03.000Ahead of Print.No.33Comparing body composition techniques against an adapted multicompartment model in individuals with excess body weight不同体成分测量技术与改良多室模型在超重个体中的比较DOI: 10.1016/j.nut.2025.113033 Biochem Biophys Res Commun IF: 02.200Ahead of Print.No.34Quinones as promising agents for managing metabolic syndrome: Therapeutic and toxicological considerations醌类作为管理代谢综合征的潜力药物：治疗与毒理考量DOI: 10.1016/j.bbrc.2025.153221 Food chemistry IF: 09.800Ahead of Print.No.35Selenium-enriched chickpea beverage powders: How particle size shapes composition and functionality富硒鹰嘴豆饮料粉：粒径如何影响其成分与功能特性DOI: 10.1016/j.foodchem.2025.147692 Scientific reports IF: 03.900Volume 15, Issue 1No.36Drug-related hepatotoxicity risk in elderly patients with atrial fibrillation: insights from the nationwide Italian START registry老年心房颤动患者的药物相关性肝毒性风险：基于意大利全国性START注册研究的见解DOI: 10.1038/s41598-025-28502-8 BMJ case reports IF: 00.500Volume 18, Issue 12No.37Skull base osteomyelitis following Klebsiella pneumoniae meningitis in an immunocompromised host免疫功能低下宿主克雷伯菌肺炎链球菌脑膜炎后继发颅底骨髓炎DOI: 10.1136/bcr-2025-267719 J Atheroscler Thromb IF: 02.800Volume 33, Issue 1, Page 1-115No.38High-Sensitivity C-Reactive Protein and Residual Inflammatory Risk in Coronary Artery Disease: The Pathophysiology, Prognosis, and Emerging Therapies高敏C反应蛋白与冠状动脉疾病的残余炎症风险：病理生理、预后与新兴疗法DOI: 10.5551/jat.RV22044 J Atheroscler Thromb IF: 02.800Volume 33, Issue 1, Page 1-115No.39Critical Role of microRNA-33a/b in Cardiovascular and Metabolic Disease: Molecular Mechanisms and Therapeutic PerspectivesMicroRNA-33a/b在心血管与代谢疾病中的关键作用：分子机制与治疗前景DOI: 10.5551/jat.RV22045 Mymensingh medical journalVolume 35, Issue 1No.40Relationship between Body Mass Index and Dengue Severity in Hospitalized Adults: Evidence from Bangladesh住院成人患者体重指数与登革热严重程度的关系：来自孟加拉国的证据https://pubmed.ncbi.nlm.nih.gov/41474892 Mymensingh medical journalVolume 35, Issue 1No.41Klumpke's Palsy Following Minor Trauma: A Rare Presentation in a Young Adult轻微创伤后出现克隆普克麻痹：一名年轻成人的罕见病例https://pubmed.ncbi.nlm.nih.gov/41474925 American journal of nephrology IF: 03.200Ahead of Print.No.42Triglyceride-glucose index, systolic blood pressure and risk of tubular atrophy/interstitial fibrosis in IgA nephropathyIgA肾病患者中甘油三酯-葡萄糖指数、收缩压与肾小管萎缩/间质纤维化风险DOI: 10.1159/000550298 JMIR formative research IF: 02.100Volume 9, Issue No.43Prescribing Experiences, Potentials, and Challenges of Digital Health Applications in the Field of Hormones and Metabolism: Cross-Sectional Survey Study of Health Care Providers in Germany激素与代谢领域数字健康应用的处方经验、潜力与挑战：德国医疗保健提供者横断面调查研究DOI: 10.2196/77792 JMIR Cardio IF: 02.200Volume 9, Issue No.44Predicting Atrial Fibrillation Ablation Outcomes: Machine Learning Model Development and Validation Using a Large Administrative Claims Database预测心房颤动消融结局：基于大型行政索赔数据库的机器学习模型开发与验证DOI: 10.2196/77380 Inform Health Soc Care IF: 02.400Ahead of Print.No.45Predicting the diabetes risk by analyzing symptoms using data mining techniques运用数据挖掘技术通过症状分析预测糖尿病风险DOI: 10.1080/17538157.2025.2602517 Mymensingh medical journalVolume 35, Issue 1No.46Association of Acidosis and Inflammation with Low Serum Albumin in CKD Stages 3-5 Predialysis PatientsCKD 3-5期透析前患者酸中毒和炎症与低血清白蛋白的关联https://pubmed.ncbi.nlm.nih.gov/41474916 Mymensingh medical journalVolume 35, Issue 1No.47Association of Serum Vitamin D Status with Gestational Diabetes Mellitus: An Experience from a Tertiary Level Specialized Diabetic Hospital in Bangladesh血清维生素D状态与妊娠期糖尿病相关性的研究：来自孟加拉国一家三级专科糖尿病医院的经验https://pubmed.ncbi.nlm.nih.gov/41474908 Mymensingh medical journalVolume 35, Issue 1No.48Identification of Causes and Diagnostic Difficulty in Managing Paediatric Pancreatitis: Experience at A Tertiary Care Center of Resource-Constraint Country资源有限国家三级医疗中心管理经验：儿科胰腺炎的病因识别与诊断困境https://pubmed.ncbi.nlm.nih.gov/41474905 Mymensingh medical journalVolume 35, Issue 1No.49Trimetazidine Ameliorates Progression of Diabetic Nephropathy by Reducing Serum Creatinine Level in Streptozotocin Induced Diabetic Rats曲美他嗪通过降低链脲佐菌素诱导的糖尿病大鼠血清肌酐水平改善糖尿病肾病进展https://pubmed.ncbi.nlm.nih.gov/41474898 Mymensingh medical journalVolume 35, Issue 1No.50Prescribing Pattern of Oral Anti-diabetic Agents among Patients with Type 2 Diabetes in Outpatient Department of a Tertiary Care Hospital in Bangladesh孟加拉国某三级医院门诊2型糖尿病患者口服降糖药物的处方模式https://pubmed.ncbi.nlm.nih.gov/41474893 Mymensingh medical journalVolume 35, Issue 1No.51Assessment of Serum Ferritin in Patients with Type 2 Diabetes Mellitus评估2型糖尿病患者血清铁蛋白水平https://pubmed.ncbi.nlm.nih.gov/41474891 Mymensingh medical journalVolume 35, Issue 1No.52Association of Glycemic Gap with In-Hospital Adverse Outcome after First Attack of Acute ST Elevation Myocardial Infarction in Thrombolysed Patients血糖间隙与接受溶栓治疗的急性ST段抬高型心肌梗死患者院内不良结局的关联https://pubmed.ncbi.nlm.nih.gov/41474890 Mymensingh medical journalVolume 35, Issue 1No.53Medial Plantar Artery Flap for Heel Reconstruction: A Retrospective Observational Study足跟重建的足底内侧动脉皮瓣：一项回顾性观察研究https://pubmed.ncbi.nlm.nih.gov/41474889 PloS one IF: 02.600Volume 20, Issue 12No.54Clinical and social determinants of cardiovascular risk in a population with chronic noncommunicable diseases in Maicao, La Guajira, Colombia: 2024哥伦比亚拉瓜希拉省迈考地区慢性非传染性疾病人群心血管风险的临床与社会决定因素：2024年研究DOI: 10.1371/journal.pone.0340101 PloS one IF: 02.600Volume 20, Issue 12No.55Trixis angustifolia DC. as a potential plant for the co-management of diabetes mellitus and tuberculosisTrixis angustifolia DC.作为糖尿病与肺结核共管的潜在药用植物DOI: 10.1371/journal.pone.0339176 PloS one IF: 02.600Volume 20, Issue 12No.56The Peak Plasma Concentration (Cmax)/Minimum Inhibitory Concentration (MIC) of bedaquiline and levofloxacin with special attention to the sputum conversion in the treatment of multidrug-resistant tuberculosis in Indonesia贝达喹啉和左氧氟沙星的峰浓度/最低抑菌浓度 (Cmax/MIC) 与印度尼西亚多重耐药肺结核治疗中痰培养阴转关系的研究DOI: 10.1371/journal.pone.0336210 PloS one IF: 02.600Volume 20, Issue 12No.57Stepping forward: A study protocol for developing and validating a Malaysian diabetic foot self-care practice assessment instrument迈步向前：一项用于开发和验证马来西亚糖尿病足自我护理实践评估工具的研究方案DOI: 10.1371/journal.pone.0337754 J Am Podiatr Med Assoc IF: 00.600Volume 115, Issue 6No.58Associations of Diabetic Foot Infection with Ulcer Prognosis and Amputation Timing in Patients with Type 2 Diabetes Mellitus2型糖尿病患者足部感染与溃疡预后及截肢时机的关联DOI: 10.7547/23-230 J Am Podiatr Med Assoc IF: 00.600Volume 115, Issue 6No.59Impact of COVID-19 Pandemic on Diabetic Foot Ulcer Management in Kalamazoo, MichiganCOVID-19大流行对美国密歇根州卡拉马祖地区糖尿病足溃疡管理的影响DOI: 10.7547/24-036 J Am Podiatr Med Assoc IF: 00.600Volume 115, Issue 6No.60Canines Masticating on the Lower Extremity犬只啃食糖尿病患者足部/趾部：现象与警示DOI: 10.7547/24-071 Journal of glaucoma IF: 01.800Ahead of Print.No.61Surgical Outcomes of Ahmed Glaucoma Valve in Neovascular Glaucoma Secondary to Diabetic Retinopathy Versus Central Retinal Vein OcclusionAhmed青光眼引流阀在糖尿病视网膜病变与视网膜中央静脉阻塞所致新生血管性青光眼中的手术结局比较DOI: 10.1097/IJG.0000000000002680 PloS one IF: 02.600Volume 20, Issue 12No.62Correction: FedGAN: Federated diabetic retinopathy image generation更正：FedGAN：联邦糖尿病视网膜病变图像生成DOI: 10.1371/journal.pone.0340003 J Clin Exp Neuropsychol IF: 01.700Ahead of Print.No.63Conversion of subjective cognitive decline to MCI and dementia: a systematic review and meta-analysis of sex differences and risk factors主观认知下降向轻度认知障碍及痴呆的转化：性别差异与风险因素的系统综述和荟萃分析DOI: 10.1080/13803395.2025.2609824 Arch Gynecol Obstet IF: 02.500Volume 313, Issue 1No.64Antepartum prediction of shoulder dystocia using machine learning应用机器学习进行产前肩难产预测DOI: 10.1007/s00404-025-08271-5 The journal of physiology IF: 04.400Ahead of Print.No.65Kidney disease impairs tendon function in rats肾病损害大鼠肌腱功能DOI: 10.1113/JP289753 Epilepsia IF: 06.600Ahead of Print.No.66Drug-resistant glutamic acid decarboxylase 65-associated epilepsy: Pre-surgical evaluation and comparison to temporal lobe epilepsy of other etiology药物难治性谷氨酸脱羧酶65相关癫痫的术前评估及与其他病因颞叶癫痫的比较DOI: 10.1002/epi.70068 Annals of African medicine IF: 00.600Ahead of Print.No.67Repeated Multiple Episodes of Furunculosis in a Young Brittle Diabetic, Successfully Treated一例年轻脆性糖尿病患者反复多发疖病的成功治疗DOI: 10.4103/aam.aam_566_25 Postgraduate medical journal IF: 02.700Ahead of Print.No.68Pharmacogenetics of incretin-based therapies基于肠促胰素疗法的药物遗传学DOI: 10.1093/postmj/qgaf232 Diabetic medicine IF: 03.400Ahead of Print.No.69Progression of albumin/creatinine ratio (ACR) and estimated glomerular filtration rate (eGFR) over 24 years in people with type 2 diabetes. Drivers, potential protectors and associated mortality2型糖尿病患者24年间尿白蛋白/肌酐比值（ACR）和估算肾小球滤过率（eGFR）的进展：驱动因素、潜在保护因素及相关死亡率DOI: 10.1111/dme.70193 Small IF: 12.100Ahead of Print.No.703D-Printed Auxetic Hydrogel Dressings Reinforced With MXene and Carbonized Polymer Dots for Cascaded Antibacterial and Pro-Regenerative Effects in Wound Healing3D打印含MXene和碳化聚合物点的拉胀水凝胶敷料用于伤口愈合中的级联抗菌和促再生效应DOI: 10.1002/smll.202508633 eLifeVolume 13, Issue No.71JAK-STAT pathway activation compromises nephrocyte function in a Drosophila high-fat diet model of chronic kidney diseaseJAK-STAT通路激活损害果蝇高脂饮食慢性肾脏病模型中的肾细胞功能DOI: 10.7554/eLife.96987 J Diabetes Investig IF: 03.000Ahead of Print.No.72The biology of PKM2 in the metabolism and senescence in diabetic kidney diseasePKM2在糖尿病肾病代谢与衰老中的生物学作用DOI: 10.1111/jdi.70231 Arch Gynecol Obstet IF: 02.500Volume 313, Issue 1No.73The outcomes of pregnancy after metabolic and bariatric surgery: a literature review代谢与减重手术后妊娠结局：一项文献综述DOI: 10.1007/s00404-025-08290-2 Lung India IF: 01.200Volume 43, Issue 1No.74Impact of metabolically healthy and metabolically unhealthy obesity on cardiac arrest and mortality in pulmonary embolism hospitalizations in elderly patients with cancer代谢健康与代谢不健康肥胖对老年癌症患者肺栓塞住院期间心脏骤停及死亡率的影响DOI: 10.4103/lungindia.lungindia_134_25 Hepatology research IF: 03.400Ahead of Print.No.75Post-COVID-19 Changes in Body Composition and Adiposity in Patients With Chronic Liver Disease: A Longitudinal Study From Japan慢性肝病患者在COVID-19后身体成分与肥胖状态的变化：一项来自日本的纵向研究DOI: 10.1111/hepr.70114 J Clin Pharmacol IF: 02.300Volume 66, Issue 1No.76Population Pharmacokinetics to Support Intravenous and Enteral Methadone Dosing in Children基于群体药代动力学优化儿童静脉及肠内美沙酮给药方案DOI: 10.1002/jcph.70143 The journal of physiology IF: 04.400Ahead of Print.No.77First in-human microelectrode recordings of vagus nerve activity in heart failure心力衰竭患者迷走神经活动的微电极记录DOI: 10.1113/JP290343 Journal of periodontology IF: 03.800Ahead of Print.No.78Hyperglycemia exacerbates placental inflammation induced by Porphyromonas gingivalis-lipopolysaccharide高血糖加剧由牙龈卟啉单胞菌脂多糖诱导的胎盘炎症DOI: 10.1002/jper.70051 Diabetes care IF: 16.600Ahead of Print.No.79Metabolic Factors Modulating the Connection Between Diabetes and Pulmonary Alterations调控糖尿病与肺部改变关联的代谢因素DOI: 10.2337/dc25-2334 Computers, informatics, nursing IF: 01.900Ahead of Print.No.80A Digital Diabetes Clinic Intervention for Individuals Starting Insulin Therapy: Randomized Controlled Trial针对起始胰岛素治疗个体的数字糖尿病诊所干预：一项随机对照试验DOI: 10.1097/CIN.0000000000001439 Lung India IF: 01.200Volume 43, Issue 1No.81Burden and impact of pulmonary embolism in young adults hospitalized with sarcoidosis: Underreported data from nationwide analysis (2016-2020)住院年轻成人结节病患者中肺栓塞的负担与影响：来自全国性分析（2016-2020年）的未被充分报告的数据DOI: 10.4103/lungindia.lungindia_375_25 BMC Sports Sci Med Rehabil IF: 02.800Volume 17, Issue 1No.82Acute hematological, metabolic, and inflammatory responses to simulated-6000 ft masked versus unmasked high-intensity interval training in youth soccer players: a randomized crossover pilot study青少年足球运动员对模拟6000英尺海拔训练面罩与无面罩高强度间歇训练的急性血液学、代谢和炎症反应：一项随机交叉试验研究DOI: 10.1186/s13102-025-01426-6 Medicina IF: 02.400Volume 61, Issue 12No.83Dysregulation of Niacin-Derived NAD(+) Salvage Pathway Markers (CD38, NAMPT, SIRT1) Across Albuminuria Stages in Type 2 Diabetes2型糖尿病中烟酰胺来源的NAD+补救途径标志物（CD38、NAMPT、SIRT1）在白蛋白尿各阶段的失调DOI: 10.3390/medicina61122089 Curēus IF: 01.300Volume 17, Issue 12No.84Morbidity in Elderly Women Undergoing Pelvic Floor Reconstruction老年女性接受盆底重建术的围手术期发病率研究DOI: 10.7759/cureus.100361 American journal of medicine openVolume 14, Issue No.85GLP-1 Receptor Agonists Initiation and Risk of Acute Pancreatitis and Pancreatic Cancer: A Real-World Comparative StudyGLP-1受体激动剂起始治疗与急性胰腺炎及胰腺癌风险：一项真实世界比较研究DOI: 10.1016/j.ajmo.2025.100114 Rev Panam Salud Publica IF: 02.200Volume 49, Issue No.86[Situation of essential conditions for the delivery of care for noncommunicable diseases in the Bolivian Chaco regionSituação das condições essenciais para a atenção a doenças não transmissíveis na região do Chaco boliviano]玻利维亚查科地区非传染性疾病护理基本条件的现状评估DOI: 10.26633/RPSP.2025.135 Clinical case reports IF: 00.600Volume 14, Issue 1No.87An Epileptic Girl With Erotomania Using Carbamazepine|Resistant to Treatment and Challenge of Starting Clozapine一名使用卡马西平的癫痫伴钟情妄想女性患者：治疗抵抗与启用氯氮平的挑战DOI: 10.1002/ccr3.71741 Frontiers in public health IF: 03.400Volume 13, Issue No.88Adherence to Mediterranean diet and physical activity practice in general population: an intersectional analysis of inequalities by sex and economic status普通人群中地中海饮食依从性与体力活动的实践：基于性别与经济状况的交叉性不平等分析DOI: 10.3389/fpubh.2025.1727223 Journal of migration and health IF: 02.900Volume 12, Issue No.89Perspectives of humanitarian actors on interprofessional care for persons living with diabetes: Lessons from Aleppo, Syria人道主义工作者对糖尿病患者跨专业护理的视角：来自叙利亚阿勒颇的经验DOI: 10.1016/j.jmh.2025.100355 Curēus IF: 01.300Volume 17, Issue 11No.90Roles of Psychiatry, Dietary, and Oncology Services in Occupational Medicine: A Comprehensive Review精神病学、营养学与肿瘤学服务在职业医学中的作用：一项综合综述DOI: 10.7759/cureus.98069 Curēus IF: 01.300Volume 17, Issue 11No.91Prevalence and Associated Factors of Glaucoma Among Adults in a Tertiary Care Center in Dubai, United Arab Emirates: A Retrospective Review阿拉伯联合酋长国迪拜一家三级医疗中心成人青光眼患病率及相关因素：一项回顾性研究DOI: 10.7759/cureus.98105 Curēus IF: 01.300Volume 17, Issue 11No.92Effective Limb Salvage Using a Distally Based Peroneus Brevis Flap for Distal Tibial Osteomyelitis使用远端蒂腓骨短肌瓣有效保肢治疗胫骨远端骨髓炎DOI: 10.7759/cureus.98065 ARYA Atherosclerosis IF: 00.600Volume 21, Issue 6No.93Six-month survival and predictors of mortality after ischemic stroke: A prospective cohort study in Iran伊朗缺血性卒中后六个月生存率及死亡预测因素：一项前瞻性队列研究DOI: 10.48305/arya.2025.45310.3060 South Asian journal of cancer IF: 00.600Volume 14, Issue 4No.94Practice Patterns and Incidence of F ebrile Neutr o penia in Patients R eceiving T riplet Drug Chemotherapeutic Regimens in G U T Cancers: Do We Need to Add WBC Growth Factors? (ForGeT GCSF Study)GU癌症患者接受三联药物化疗方案中的实践模式与发热性中性粒细胞减少症发生率：是否需要添加WBC生长因子？（ForGeT GCSF研究）DOI: 10.1055/s-0044-1789590 Frontiers in nutrition IF: 05.100Volume 12, Issue No.95Impact of α-linolenic acid supplementation on long-chain n-3 fatty acid profiles in Western, flexitarian, vegetarian, and vegan diets补充α-亚麻酸对西方、弹性素食、素食及纯素食饮食中长链n-3脂肪酸谱的影响DOI: 10.3389/fnut.2025.1727308 Korean J Community NutrVolume 29, Issue 1No.96[Association of ultra-processed food with diabetes and impaired fasting glucose in elderly populations (urban and rural): a cross-sectional study]韩国城乡老年人超加工食品摄入与糖尿病及空腹血糖受损的关联：一项横断面研究DOI: 10.5720/kjcn.2024.29.1.51 Nigerian Medical journalVolume 66, Issue 4No.97Glycemic control among People living with HIV and diabetes in Eastern Uganda: A cross-sectional study乌干达东部地区HIV合并糖尿病患者的血糖控制情况：一项横断面研究DOI: 10.71480/nmj.v66i4.984 Nigerian Medical journalVolume 66, Issue 4No.98Serum Galectin-3 as a Prognostic Biomarker in Acute Ischemic Stroke: A Comparative Cross-Sectional Study血清Galectin-3作为急性缺血性卒中预后生物标志物的比较横断面研究DOI: 10.71480/nmj.v66i4.875 NFS journal IF: 03.300Volume 41, Issue No.99Skeletal muscle disuse atrophy: protection by omega-3 polyunsaturated fatty acids骨骼肌废用性萎缩：omega-3多不饱和脂肪酸的保护作用DOI: 10.1016/j.nfs.2025.100253 J Integr Complement Med IF: 01.700Ahead of Print.No.100The Effects of Mandala Coloring Applied to Type 2 Diabetes Patients on Levels of Perceived Stress and Anxiety: A Randomized Controlled Study应用于2型糖尿病患者的曼陀罗绘画对感知压力和焦虑水平的影响：一项随机对照研究DOI: 10.1177/27683605251406492 Diabetic medicine IF: 03.400Ahead of Print.No.101Leaving better managed than when they arrived: A window of opportunity for people with diabetes admitted to hospital出院时病情管理优于入院：住院糖尿病患者的机遇之窗DOI: 10.1111/dme.70212 Diabetic medicine IF: 03.400Ahead of Print.No.102Healing through empowerment and active listening (HEALing): A mixed-methods evaluation of the feasibility and acceptability of a nurse-led self-care support intervention for people with diabetic foot ulcers通过赋能与积极倾听促进愈合：一项关于护士主导的糖尿病足溃疡患者自我护理支持干预措施的可行性、可接受性及效果混合方法研究评估DOI: 10.1111/dme.70187 Journal of cosmetic dermatology IF: 02.500Volume 25, Issue 1No.103Safety of Exogenous Recombinant Human Platelet-Derived Growth Factor-BB (rhPDGF-BB) for Medical and Cosmetic Applications: A Review外源性重组人血小板衍生生长因子-BB（rhPDGF-BB）在医学和美容应用中安全性的综述DOI: 10.1111/jocd.70636 Ann Otol Rhinol Laryngol IF: 01.200Ahead of Print.No.104Chronic Bacterial and Sicca Laryngitis: A Retrospective Cohort and Systematic Review慢性细菌性与干燥性喉炎：一项回顾性队列研究及系统综述DOI: 10.1177/00034894251405127 Gut and liver IF: 03.200Ahead of Print.No.105Increased Heart Failure Risk with Gastric Cancer Progression: A Nationwide Population-Based Cohort Study胃癌进展与心力衰竭风险增加相关：一项全国性人群队列研究DOI: 10.5009/gnl250209 Microorganisms IF: 04.200Volume 13, Issue 12No.106Fatal Congenital Toxoplasmosis with Progressive Liver Failure and Genomic Characterization of a Novel Isolate from the United States美国报告一例伴进行性肝衰竭的致死性先天性弓形虫病及其新型分离株的基因组特征分析DOI: 10.3390/microorganisms13122865 Microorganisms IF: 04.200Volume 13, Issue 12No.107Bacterial Adaptation to Stress Induced by Glyoxal/Methylglyoxal and Advanced Glycation End Products细菌对乙二醛/丙酮醛和晚期糖基化终末产物所致应激的适应DOI: 10.3390/microorganisms13122778 Microorganisms IF: 04.200Volume 13, Issue 12No.108Rhino-Orbital-Cerebral Mucormycosis Complicated by Vision Loss in a Patient with Uncontrolled Diabetes: A Case Report未控制糖尿病患者并发视力丧失的鼻-眶-脑毛霉菌病：一例报告DOI: 10.3390/microorganisms13122695 Molecules IF: 04.600Volume 30, Issue 24No.109Novel Trinorditerpene from Dysoxylum parasiticum (Osbeck) Kosterm: Leaf Extract with Cytotoxic, Antioxidant and α-Glucosidase Inhibitory Activities寄主臭椿叶片提取物中的新颖三降二萜：具有细胞毒性、抗氧化及α-葡萄糖苷酶抑制活性DOI: 10.3390/molecules30244747 Pharmaceuticals IF: 04.800Volume 18, Issue 12No.110Risk Factors for Intolerable Postoperative Pain After Vitreoretinal Surgery Under AoA-Guided General Anesthesia with Intravenous COX-3 Inhibitors: A Post Hoc AnalysisAoA引导的全身麻醉联合静脉COX-3抑制剂下玻璃体视网膜手术后难以忍受性疼痛的风险因素：一项事后分析DOI: 10.3390/ph18121826 Pharmaceuticals IF: 04.800Volume 18, Issue 12No.111Production of a Dulaglutide Analogue by Apoptosis-Resistant Chinese Hamster Ovary Cells in a 3-Week Fed-Batch Process抗凋亡中国仓鼠卵巢细胞在3周补料分批培养工艺中生产度拉糖肽类似物DOI: 10.3390/ph18121896 Avicenna journal of medicineVolume 15, Issue 4No.112Burden and Factors Associated with Depression and Anxiety Disorders in Pediatric Asthma: A Cross-Sectional Study儿童哮喘患者抑郁与焦虑障碍的负担及相关因素：一项横断面研究DOI: 10.1055/s-0045-1814096 Digital health IF: 03.300Volume 11, Issue No.113A deep learning-based early prediction framework for weight management using real-world lifelog data: GRU-ODE-Bayes model development and validation study基于深度学习的体重管理早期预测框架：利用真实世界生活日志数据的GRU-ODE-Bayes模型开发与验证研究DOI: 10.1177/20552076251406656 Health science reports IF: 02.100Volume 9, Issue 1No.114Awareness of Obesity and Diabetes in Libya: Insights From a Cross-Sectional Study利比亚肥胖与糖尿病意识：一项横断面研究的启示DOI: 10.1002/hsr2.71654 Health science reports IF: 02.100Volume 9, Issue 1No.115Association Between Adiposity and Low Total Serum Bilirubin Concentration: A Retrospective, Cross-Sectional Study脂肪含量与低总血清胆红素浓度之间的关联：一项回顾性横断面研究DOI: 10.1002/hsr2.71700 Journal of migration and health IF: 02.900Volume 12, Issue No.116A scoping review of overweight and obesity prevalence and determinants among immigrant adults in Nordic countries斯堪的纳维亚国家移民成人超重与肥胖患病率及决定因素的范围综述DOI: 10.1016/j.jmh.2025.100377 Przegl?d Gastroenterologiczny IF: 02.500Volume 20, Issue 4No.117Concordance of the rapid urease test and the histopathology report in detecting Helicobacter pylori infection in a bariatric population. A retrospective cohort study减重手术人群中快速尿素酶试验与组织病理学报告检测幽门螺旋杆菌感染的一致性：一项回顾性队列研究DOI: 10.5114/pg.2025.156847 Applications in plant sciences IF: 02.400Volume 13, Issue 6No.118PlantSAM: An object detection-driven segmentation pipeline for herbarium specimensPlantSAM：一种面向植物标本、由目标检测驱动的分割流水线DOI: 10.1002/aps3.70034 Frontiers in nutrition IF: 05.100Volume 12, Issue No.119Nutritional factors and survival in a cohort of patients with myelofibrosis骨髓纤维化患者队列中的营养因素与生存分析DOI: 10.3389/fnut.2025.1704844 Korean J Community NutrVolume 29, Issue 1No.120Nutrition education programs necessary for social welfare facilities for persons with disabilities: a cross-sectional study残疾人士社会福利机构营养教育项目的必要性：一项横断面研究DOI: 10.5720/kjcn.2024.29.1.1 Frontiers in immunology IF: 05.900Volume 16, Issue No.121IL-6 as an integrative biomarker of residual inflammation and visceral adiposity in psoriasis: a VAI threshold-dependent modelIL-6作为银屑病中残余炎症和内脏脂肪的整合性生物标志物：一个VAI阈值依赖模型DOI: 10.3389/fimmu.2025.1699343 Headache IF: 04.000Ahead of Print.No.122A unifying disease model of idiopathic intracranial hypertension: A narrative review特发性颅内高血压的统一疾病模型：一篇叙述性综述DOI: 10.1111/head.70030 Gut and liver IF: 03.200Ahead of Print.No.123Artificial Intelligence Applications in the Diagnosis, Treatment, and Prognosis of Hepatocellular Carcinoma人工智能在肝细胞癌诊断、治疗和预后中的应用DOI: 10.5009/gnl250268 Microorganisms IF: 04.200Volume 13, Issue 12No.124The Prevalence of Perineal Tears Among Women Having Spontaneous Vaginal Births with Intrapartum Fever产时发热妇女自然阴道分娩时会阴撕裂的发生率DOI: 10.3390/microorganisms13122815 Sensors IF: 03.500Volume 25, Issue 24No.125Trajectories of Adherence to Study-Prescribed Physical Activity Goals in a mHealth Weight Loss InterventionmHealth体重管理干预中参与者遵循体力活动目标的轨迹研究DOI: 10.3390/s25247595 Pharmaceuticals IF: 04.800Volume 18, Issue 12No.126The Impact of Maternal BMI on the Efficacy and Safety of Oral Misoprostol for Labor Induction母体BMI对口服米索前列醇引产的有效性和安全性的影响DOI: 10.3390/ph18121888 Pharmaceuticals IF: 04.800Volume 18, Issue 12No.127Coixol and Sinigrin from Coix lacryma-jobi L. and Raphanus sativus L. Promote Fat Browning in 3T3-L1 Adipocytes薏苡仁中的薏苡仁酯与萝卜籽中的黑芥子苷促进3T3-L1脂肪细胞脂肪棕色化DOI: 10.3390/ph18121843 Pharmaceuticals IF: 04.800Volume 18, Issue 12No.1286,7-Dihydroxy-4-methylcoumarin Suppresses Adipogenesis via AMPK and MAPK Signaling with In Silico Analysis of Adipogenic Proteins6,7-二羟基-4-甲基香豆素通过AMPK和MAPK信号通路抑制脂肪生成及基于脂肪生成蛋白的计算机模拟分析DOI: 10.3390/ph18121780 Nutrients IF: 05.000Volume 17, Issue 24No.129Use of Weight Loss Supplements According to the Purported Mechanisms of Action Among Polish Adults Living in an Obesogenic Environment: The Role of Sociodemographic and Health-Related Factors据宣称的作用机制分析波兰生活在致肥环境中成年人的减肥补充剂使用：社会人口与健康相关因素的作用DOI: 10.3390/nu17243963 Nutrients IF: 05.000Volume 17, Issue 24No.130Association Between Healthy Lifestyle and Cardiometabolic Risk in Higher Education Students in a Region of Peru: A Cross-Sectional Survey秘鲁某地区高等教育学生健康生活方式与心脏代谢风险的关联：一项横断面调查DOI: 10.3390/nu17243944 Nutrients IF: 05.000Volume 17, Issue 24No.131Learning from Peers: A Qualitative Study to Inform the Development of a Community Tailored Peer Support Intervention to Support Healthy Infant Growth向同伴学习：一项为制定社区定制化同伴支持干预以促进婴儿健康生长的定性研究DOI: 10.3390/nu17243941 Nutrients IF: 05.000Volume 17, Issue 24No.132Maternal Eating Styles and Restrictive Feeding Practices: Indirect Effects Through Perceived Child Appetite and Weight Concern母亲饮食风格与限制性喂养行为：通过感知儿童食欲和体重担忧的间接影响DOI: 10.3390/nu17243933 Nutrients IF: 05.000Volume 17, Issue 24No.133The Relationship of Sensory Profiles and Peripheral Biomarkers with Obesity and Eating Styles in Adolescence青少年肥胖与进食方式中感官特征及外周生物标志物的关系DOI: 10.3390/nu17243923 Nutrients IF: 05.000Volume 17, Issue 24No.134Eating Disorders in an Immigrant Population: Are Clinical Features and Treatment Outcomes Different from the Native-Born Spanish Population?移民人群的进食障碍：其临床特征与治疗结果是否与本土西班牙人群不同？DOI: 10.3390/nu17243914 Nutrients IF: 05.000Volume 17, Issue 24No.135Identifying Distinct Profiles of Nutrition Knowledge and Dietary Practices, and Their Determinants Among Adult Women: A Cross-Sectional Study识别成年女性营养知识与膳食实践的不同特征及其决定因素：一项横断面研究DOI: 10.3390/nu17243916 Nutrients IF: 05.000Volume 17, Issue 24No.136Dietary Patterns Influence Chronic Disease Risk and Health Outcomes in Older Adults: A Narrative Review膳食模式影响老年人慢性病风险与健康结局：一项叙述性综述DOI: 10.3390/nu17243910 Nutrients IF: 05.000Volume 17, Issue 24No.137Olfactory Capacity and Obesity in Chilean Adolescents智利青少年的嗅觉能力与肥胖DOI: 10.3390/nu17243903 Nutrients IF: 05.000Volume 17, Issue 24No.138The Impact of Physical Activity at School on the Nutritional Behavior of Overweight Children学校体力活动对超重儿童营养行为的影响DOI: 10.3390/nu17243905 Nutrients IF: 05.000Volume 17, Issue 24No.139Controversies and Perspectives of Time-Qualified Dietary Interventions时间限定饮食干预的争议与前景DOI: 10.3390/nu17243894 Nutrients IF: 05.000Volume 17, Issue 24No.140The Impact of Mindfulness Interventions upon Visual Attention and Attentional Bias Towards Food Cues: A Systematic Review正念干预对视觉注意及对食物线索注意偏向的影响：一项系统综述DOI: 10.3390/nu17243885 Nutrients IF: 05.000Volume 17, Issue 24No.141Early-Life Nutritional Determinants of Pediatric MASLD儿科代谢功能障碍相关脂肪性肝病的早期营养决定因素DOI: 10.3390/nu17243871 Nutrients IF: 05.000Volume 17, Issue 24No.142Clinical Implementation of Sustainable Functional Foods and Nutraceuticals in Metabolic Health: A Feasibility Study可持续功能性食品与营养素在代谢健康中的临床应用：一项可行性研究DOI: 10.3390/nu17243858 Nutrients IF: 05.000Volume 17, Issue 24No.143Lactiplantibacillus plantarum Strain 06CC2 Attenuates Fat Accumulation and Modulates the Gut Microbiota in a Mouse Model of Early-Stage Diet-Induced Obesity植物乳杆菌菌株06CC2减轻早期饮食诱导肥胖小鼠模型的脂肪积累并调节肠道菌群DOI: 10.3390/nu17243855 Nutrients IF: 05.000Volume 17, Issue 24No.144Role of Bioelectrical Impedance Analysis in Detecting Nutritional Disorders in Institutionalized Psychogeriatric Patients生物电阻抗分析在检测机构化老年精神科患者营养障碍中的作用DOI: 10.3390/nu17243839 Nutrients IF: 05.000Volume 17, Issue 24No.145Leader-Inspired Nutrition: A Framework for Promoting Healthy Nutrition Behaviors and a Nutritionally Fueled and Fit Military Force领导力驱动的营养：促进健康营养行为与构建营养驱动型军事强健力量的框架DOI: 10.3390/nu17243835 Nutrients IF: 05.000Volume 17, Issue 24No.146Determinants of the Availability of Special Diet Meals in Public Schools from Kraków (Poland): A Cross-Sectional Analysis波兰克拉科夫公立学校特殊膳食供应的决定因素：一项横断面分析DOI: 10.3390/nu17243834 Nutrients IF: 05.000Volume 17, Issue 24No.147The Role of Nutrition in the Development, Management, and Prevention of Rheumatoid Arthritis: A Comprehensive Review营养在类风湿关节炎发生、管理与预防中的作用：综合评述DOI: 10.3390/nu17243826 Nutrients IF: 05.000Volume 17, Issue 24No.148Exploring Obesity Subtypes: Cluster Analysis of Eating Behaviors, Food Addiction, and Psychopathology in Turkish Adults Seeking Obesity Treatment探索肥胖亚型：对寻求肥胖治疗的土耳其成年人的饮食行为、食物成瘾和精神病理学进行聚类分析DOI: 10.3390/nu17243823 Nutrients IF: 05.000Volume 17, Issue 24No.149Validity and Reliability of the Danish Version of the Adult Eating Behavior Questionnaire-Results from the South Danish Obesity Initiative成人进食行为问卷丹麦版的有效性和可靠性——来自南丹麦肥胖倡议的结果DOI: 10.3390/nu17243824 Nutrients IF: 05.000Volume 17, Issue 24No.150Health and Nutrition Interventions to Prevent Childhood Overweight and Obesity in Mexico and Latin America: A Systematic Review预防墨西哥及拉丁美洲儿童超重与肥胖的健康与营养干预措施：一项系统综述DOI: 10.3390/nu17243818 Nutrients IF: 05.000Volume 17, Issue 24No.151Assessment of Health Status, Emotional Well-Being, and the Prevalence of Overweight and Obesity in Children and Adolescents in the PICTURE Study (Wroclaw, Poland)PICTURE研究（波兰弗罗茨瓦夫）中儿童青少年健康状况、情感福祉及超重肥胖患病率评估DOI: 10.3390/nu17243817 Medicina IF: 02.400Volume 61, Issue 12No.152Six-Month Quality of Life and Health Outcomes After Bariatric Surgery: A Prospective Cohort Study from Latvia减重手术后六个月的生活质量与健康结局：一项来自拉脱维亚的前瞻性队列研究DOI: 10.3390/medicina61122238 Medicina IF: 02.400Volume 61, Issue 12No.153Long-Term Cancer Incidence Trends in Korea (2001-2020): An Age-Period-Cohort and Joinpoint Analysis with a Focus on Younger Cohorts韩国癌症发病率长期趋势（2001-2020）：基于年龄-时期-队列和连接点模型的分析，聚焦年轻队列DOI: 10.3390/medicina61122179 Cancer medicine IF: 03.100Volume 15, Issue 1No.154Positive Association Between Body Mass Index and the Likelihood of Reporting an Overall Cancer Diagnosis Among College Students in the United States美国大学生体重指数与自我报告癌症总体诊断可能性呈正相关DOI: 10.1002/cam4.71508 BMC public health IF: 03.600Volume 25, Issue 1No.155A preliminary study on the development of a chronic disease self-management curriculum for disability support workers: educational needs analysis针对残疾支持工作者的慢性病自我管理课程开发初步研究：教育需求分析DOI: 10.1186/s12889-025-25659-9 Journal of neuroscience research IF: 03.400Volume 104, Issue 1No.156Modulation of Magnetic Resonance Spectroscopy Levels of Glutamate and GABA by Ketamine in Treatment-Resistant Depression氯胺酮对难治性抑郁症患者磁共振波谱谷氨酸和γ-氨基丁酸水平的调节作用DOI: 10.1002/jnr.70102 Nutrients IF: 05.000Volume 17, Issue 24No.157Ophiopogon japonicus Root Extract Attenuates Obesity-Induced Muscle Atrophy Through Regulation of the PI3K-AKT-mTOR/FoxO3a Signaling Pathway and Lipid Metabolism in Mice and C2C12 Myotubes麦冬根提取物通过调节PI3K-AKT-mTOR/FoxO3a信号通路和脂质代谢减轻小鼠和C2C12肌管肥胖诱导的肌肉萎缩DOI: 10.3390/nu17243946 Nutrients IF: 05.000Volume 17, Issue 24No.158How the Intake of Pulses May Impact Metabolic Disorders and Dementia Risk: A Narrative Review脉冲摄入如何影响代谢紊乱和痴呆风险：一篇叙述性综述DOI: 10.3390/nu17243898 Nutrients IF: 05.000Volume 17, Issue 24No.159Nutrition and Physical Activity in an Interdisciplinary Approach to Migraine: A Narrative Review营养与体力活动在偏头痛跨学科治疗中的整合：一项叙述性综述DOI: 10.3390/nu17243869 Medicina IF: 02.400Volume 61, Issue 12No.160A Nationwide Analysis of Diabetes Mellitus and Intracranial Injuries: No Impact on Mortality but Prolonged Hospital Stays in Germany德国全国性分析：糖尿病与颅内损伤——对死亡率无影响但延长住院时间DOI: 10.3390/medicina61122187 Alzheimer's & dementia IF: 06.800Volume 12, Issue 1No.161Critical evaluation of real-world evidence of repurposable medicines in the Alzheimer's disease drug development pipeline using a target trial emulation基于目标试验仿真对阿尔茨海默病药物研发管线中可再利用药物的真实世界证据进行批判性评估DOI: 10.1002/trc2.70193 Tissue barriers IF: 04.000Ahead of Print.No.162Current therapeutic strategies in the management of diabetic foot ulcers当前糖尿病足溃疡的治疗策略DOI: 10.1080/21688370.2025.2611185 Molecules IF: 04.600Volume 30, Issue 24No.163From Elixirs to Geroscience: A Historical and Molecular Perspective on Anti-Aging Medicine从长生药到老年科学：抗衰老医学的历史与分子视角DOI: 10.3390/molecules30244728 Pharmaceuticals IF: 04.800Volume 18, Issue 12No.164Metformin Mitigates Diabetes-Driven Renal Senescence via Immunomodulation and the FABP4/FOXO1 Axis二甲双胍通过免疫调节及FABP4/FOXO1轴缓解糖尿病驱动的肾脏衰老DOI: 10.3390/ph18121834 Pharmaceuticals IF: 04.800Volume 18, Issue 12No.165BMP-7 Treatment Ameliorates PTEN-Akt Mediated Apoptosis and Adverse Cardiac Remodeling in Ponatinib-Induced CardiotoxicityBMP-7治疗通过调控PTEN-Akt通路改善普纳替尼诱导心脏毒性中的细胞凋亡和不良心脏重构DOI: 10.3390/ph18121776 Medicina IF: 02.400Volume 61, Issue 12No.166Heparin Resistance in Cardiac Surgery with Cardiopulmonary Bypass: Mechanisms, Clinical Implications, and Evidence-Based Management体外循环心脏手术中的肝素抵抗：机制、临床意义与循证管理DOI: 10.3390/medicina61122088 Medicina IF: 02.400Volume 61, Issue 12No.167National Utilization and Expenditure Trends of GLP-1 Receptor Agonists and Dual GLP-1/GIP Agonist in Croatia, 2017-2024克罗地亚GLP-1受体激动剂与GLP-1/GIP双重激动剂的国家使用与支出趋势（2017-2024年）DOI: 10.3390/medicina61122210 Diabetic medicine IF: 03.400Ahead of Print.No.168Wider determinants of health are crucial confounders in benchmarking treatment standards: Diabetic ketoacidosis as an example健康广泛决定因素是基准化治疗标准中关键的混杂因素：以糖尿病酮症酸中毒为例DOI: 10.1111/dme.70209 Exp Ther Med IF: 02.300Volume 31, Issue 2No.169Metabolic gene polymorphisms and type 2 diabetes mellitus risk: A systematic review and meta-analyses代谢基因多态性与2型糖尿病风险：一项系统评价与荟萃分析DOI: 10.3892/etm.2025.13049 Curēus IF: 01.300Volume 17, Issue 11No.170Neutrophil-to-Lymphocyte Ratio (NLR): A Predictor of Microvascular Complications in Type 2 Diabetes Mellitus中性粒细胞与淋巴细胞比值（NLR）：2型糖尿病微血管并发症的预测指标DOI: 10.7759/cureus.98079 Diabetic medicine IF: 03.400Ahead of Print.No.171User evaluation of the Hypo-METRICS app: A tool for real-time symptom reporting of hypoglycaemia用户对Hypo-METRICS app的评估：一种用于低血糖实时症状报告的工具DOI: 10.1111/dme.70185 Molecules IF: 04.600Volume 30, Issue 24No.172Synthetic Flozins in Cancer Prevention and Combination Strategies: Structural Insights and Therapeutic Potential合成格列净类药物在癌症预防和联合策略中的应用：结构见解与治疗潜力DOI: 10.3390/molecules30244681 Pharmaceuticals IF: 04.800Volume 18, Issue 12No.173Nerve Growth Factor in Diabetes Mellitus: Pathophysiological Mechanisms, Biomarkers and Therapeutic Opportunities糖尿病中的神经生长因子：病理生理机制、生物标志物与治疗机遇DOI: 10.3390/ph18121805 Pharmaceutics IF: 05.500Volume 17, Issue 12No.174Pharmacokinetic Landscape and Interaction Potential of SGLT2 Inhibitors: Bridging In Vitro Findings and Clinical ImplicationsSGLT2抑制剂的药代动力学图景与相互作用潜能：衔接体外发现与临床启示DOI: 10.3390/pharmaceutics17121604 Pharmaceutics IF: 05.500Volume 17, Issue 12No.175Oral Treatment of Obesity by GLP-1 and Its AnalogsGLP-1及其类似物的口服疗法治疗肥胖DOI: 10.3390/pharmaceutics17121596 BMC Med Inform Decis Mak IF: 03.800Ahead of Print.No.176Explainable extratreeclassifier model for early detection of type 2 diabetes: evidence from the PERSIAN Dena Cohort基于PERSIAN Dena Cohort证据的2型糖尿病早期检测可解释极端树分类器模型DOI: 10.1186/s12911-025-03333-9 Medicina IF: 02.400Volume 61, Issue 12No.177Adverse Pregnancy Outcomes in Women with Gestational Diabetes Using Different Diagnostic Criteria: A Study from the Northern Adriatic Region of Croatia使用不同诊断标准时妊娠期糖尿病女性的不良妊娠结局：一项来自克罗地亚北部亚得里亚海地区的研究DOI: 10.3390/medicina61122218 BMC pregnancy and childbirth IF: 02.700Ahead of Print.No.178Comparative analysis of inflammatory and metabolic biomarkers in PGDM and GDM pregnanciesPGDM 与 GDM 妊娠中炎症和代谢生物标志物的比较分析DOI: 10.1186/s12884-025-08597-7 Medicina IF: 02.400Volume 61, Issue 12No.179Cutaneous Melanoma in the Context of Aging衰老背景下的皮肤黑色素瘤DOI: 10.3390/medicina61122115 Medicina IF: 02.400Volume 61, Issue 12No.180Elevated Epicardial Adipose Tissue and Ischemic Stroke Risk: A Systematic Review and Meta-Analysis心外膜脂肪组织增多与缺血性卒中风险：一项系统评价与荟萃分析DOI: 10.3390/medicina61122128 Medicina IF: 02.400Volume 61, Issue 12No.181Improvement of Cardiometabolic Control with Dapagliflozin in Patients with Type 2 Diabetes in Primary Care: The AGORA-AP Study达格列净改善初级保健中2型糖尿病患者心脏代谢控制：AGORA-AP研究DOI: 10.3390/medicina61122087 Viruses IF: 03.500Volume 17, Issue 12No.182Cardiac Tissue Damage in a Female Animal Post-COVID Model: Relevance of Chemokine-Mediated Inflammation新冠病毒感染后女性动物模型中的心脏组织损伤：趋化因子介导炎症的相关性DOI: 10.3390/v17121629 Medicina IF: 02.400Volume 61, Issue 12No.183Pulmonary Function and Associated Prognostic Factors in Children After COVID-19: A Retrospective Cohort Study儿童COVID-19后肺功能及相关预后因素：一项回顾性队列研究DOI: 10.3390/medicina61122136 Pharmaceuticals IF: 04.800Volume 18, Issue 12No.184Association Between DPPs-4 Inhibitors and Bullous Pemphigoid: Reporting Odds Ratio Analysis Using EudraVigilance DatabaseDPP-4抑制剂与天疱疮的关联性：基于EudraVigilance数据库的报告比值比分析DOI: 10.3390/ph18121800 American journal of medicine openVolume 14, Issue No.185The Impact of Different Antidiabetic Drugs on Fracture Risk in Patients With Type 2 Diabetes Mellitus: A Systematic Review and Network Meta-analysis of Randomized Controlled Trials With a Focus on SGLT2 Inhibitors不同降糖药物对2型糖尿病患者骨折风险的影响：聚焦于SGLT2抑制剂的随机对照试验系统综述与网络荟萃分析DOI: 10.1016/j.ajmo.2025.100115 Avicenna journal of medicineVolume 15, Issue 4No.186Understanding Type 2 Diabetes Mellitus and the Knowledge Gaps among Future Health Care Professionals: Insights from Saudi Arabia洞察沙特阿拉伯未来医疗从业者对2型糖尿病的认知与差距DOI: 10.1055/s-0045-1812884 PCN reports :Volume 4, Issue 4No.187Stereotypical diagnostic bias for alcohol-induced ketoacidosis could lead to death: Normal blood sugar levels in SGLT2 blocker-induced severe diabetic ketoacidosis对酒精性酮症酸中毒的刻板诊断偏见可能导致死亡：SGLT2抑制剂诱发重度正常血糖性糖尿病酮症酸中毒DOI: 10.1002/pcn5.70279 Curēus IF: 01.300Volume 17, Issue 11No.188Challenges and Strategies for Successful Insulin Pump Therapy in an Elderly Patient With Type 1 Diabetes and Comorbidities: A Case Report一例老年1型糖尿病合并多种并发症患者胰岛素泵治疗的成功挑战与策略：病例报告DOI: 10.7759/cureus.98093 Curēus IF: 01.300Volume 17, Issue 11No.189Polycystic Ovary Syndrome-Associated Acne: The Interplay of Hyperandrogenism, Insulin Resistance, and Therapeutic Strategies多囊卵巢综合征相关痤疮：高雄激素血症、胰岛素抵抗与治疗策略的相互作用DOI: 10.7759/cureus.98103 Curēus IF: 01.300Volume 17, Issue 11No.190Maternal Thyroid Hormone Evaluation in Women With Gestational Diabetes Mellitus in the Second Trimester孕中期妊娠期糖尿病女性的母体甲状腺激素评估DOI: 10.7759/cureus.98107 bioRxivVolume 2025, Issue No.191Small molecule inhibitor of PPARγ acetylation promotes insulin sensitization and browning of white adipose tissue with improved safetyPPARγ乙酰化小分子抑制剂促进胰岛素增敏与白色脂肪棕色化并提升安全性DOI: 10.64898/2025.12.15.694265 bioRxivVolume 2025, Issue No.192mRNA and Protein Expression of Fetal Insulin Receptor in Breast Cancer Cell Lines胎儿胰岛素受体在乳腺癌细胞系中的mRNA及蛋白表达DOI: 10.64898/2025.12.15.694420 J Clin Transl Hepatol IF: 04.200Volume 13, Issue 12No.193Nutrient-stimulated Hormone-based Therapies: A New Frontier in the Prevention and Management of MASH-associated Hepatocellular Carcinoma营养刺激激素疗法：预防和管理MASH相关肝细胞癌的新前沿DOI: 10.14218/JCTH.2025.00303 Frontiers in endocrinology IF: 04.600Volume 16, Issue No.194Enhancing insulin secretion by pancreatic β-cell redifferentiation: a study of the anti-diabetic effects of berberine in vitro通过胰腺β细胞再分化增强胰岛素分泌：小檗碱体外抗糖尿病作用研究DOI: 10.3389/fendo.2025.1658671 Frontiers in endocrinology IF: 04.600Volume 16, Issue No.195Real-world glycemic outcomes of a tubeless automated insulin delivery system: a single-center observational study in Italy无管路自动胰岛素输送系统的真实世界血糖结局：一项意大利单中心观察性研究DOI: 10.3389/fendo.2025.1717249 JCEM case reportsVolume 4, Issue 1No.196Exogenous Insulin Antibody Syndrome and Subsequent Severe Subcutaneous Insulin Resistance Complicating Type 1 Diabetes外源性胰岛素抗体综合征及后续严重皮下胰岛素抵抗并发1型糖尿病DOI: 10.1210/jcemcr/luaf300 Veterinary World IF: 02.000Volume 18, Issue 11No.197Optimization of insulin-like growth factor-1 supplementation enhances oocyte quality by modulating oxidative stress and apoptotic pathways during in vitro maturation of Kacang goat oocytes优化胰岛素样生长因子-1补充通过调节氧化应激和凋亡通路提升Kacang山羊卵母细胞体外成熟质量DOI: 10.14202/vetworld.2025.3545-3560 Frontiers in immunology IF: 05.900Volume 16, Issue No.198Macrophages: friend or foe in diabetes pathogenesis and therapy巨噬细胞：糖尿病发病机制与治疗中的朋友还是敌人？DOI: 10.3389/fimmu.2025.1625391 Frontiers in immunology IF: 05.900Volume 16, Issue No.199A diet-induced obese and diabetic host phenotype reduces mosquito ZIKV infections and remodels gut metabolism饮食诱导的肥胖与糖尿病宿主表型可降低蚊子寨卡病毒感染并重塑其肠道代谢DOI: 10.3389/fimmu.2025.1704301 Future microbiology IF: 02.400Ahead of Print.No.200Superficial fungal infections in patients with diabetes. Is hyperglycemia the only associated factor?糖尿病患者浅部真菌感染：高血糖是唯一的关联因素吗？DOI: 10.1080/17460913.2025.2607353 J Clin Endocrinol Metab IF: 05.100Ahead of Print.No.201Approach to the Patient - Mitochondrial Diabetes: Contemporary Cases and Precision Medicine Approach病例精析：线粒体糖尿病——当代病例与精准医学方法DOI: 10.1210/clinem/dgaf698 Veterinary sciences IF: 02.300Volume 12, Issue 12No.202Evaluation of Pancreatic Endocrine Reprogramming in Diabetic Cats糖尿病猫胰腺内分泌重编程的评估DOI: 10.3390/vetsci12121167 Microorganisms IF: 04.200Volume 13, Issue 12No.203Glucose-Lowering Effects and Safety of Bifidobacterium longum CKD1 in Diabetic Dogs and Cats长双歧杆菌CKD1在糖尿病犬和猫中的降血糖效应及安全性DOI: 10.3390/microorganisms13122881 Pharmaceuticals IF: 04.800Volume 18, Issue 12No.204Role of the Insulin Receptor in Mediating Cytosolic Delivery of Proteins by a Modified Cell-Penetrating Peptide胰岛素受体在介导修饰型细胞穿透肽递送蛋白质至胞质中的作用DOI: 10.3390/ph18121885 Pharmaceuticals IF: 04.800Volume 18, Issue 12No.205An Ongoing Search for Multitarget Ligands as Potential Agents for Diabetes Mellitus and Its Long-Term Complications: New Insights into (5-Arylidene-4-oxothiazolidin-3-yl)alkanoic Acid Derivatives对糖尿病及其长期并发症潜在多靶点药物的持续探索：关于（5-芳亚甲基-4-氧代噻唑烷-3-基）链烷酸衍生物的新见解DOI: 10.3390/ph18121863 Pharmaceuticals IF: 04.800Volume 18, Issue 12No.206Challenge of Corneal Ulcer Healing: A Novel Conceptual Framework, the "Triad" of Corneal Ulcer Healing/Corneal Neovascularization/Intraocular Pressure, and Avascular Tendon Healing, for Evaluation of Corneal Ulcer Therapy, Therapy of Neovascularization, Glaucoma Therapy, and Pentadecapeptide BPC 157 Efficacy角膜溃疡愈合的挑战：一种新的概念框架——“三联征”（角膜溃疡愈合↔角膜新生血管↔眼内压）以及无血管肌腱愈合——用于评价角膜溃疡治疗、新生血管治疗、青光眼治疗和十五肽BPC 157的有效性DOI: 10.3390/ph18121822 Pharmaceuticals IF: 04.800Volume 18, Issue 12No.207Curcumin and Tetrahydrocurcumin as Multi-Organ Modulators of the Adipose Tissue-Gut-Liver Axis: Mechanistic Insights, Therapeutic Potential, and Translational Challenges姜黄素与四氢姜黄素作为脂肪组织-肠道-肝脏轴的多器官调节剂：机制见解、治疗潜力与转化挑战DOI: 10.3390/ph18121791 Pharmaceutics IF: 05.500Volume 17, Issue 12No.208Systematic Development and Characterization of Enzyme-Free, Borax-Crosslinked Microneedles for Glucose-Responsive Insulin Delivery and In Vivo Glycemic Mitigation用于葡萄糖响应性胰岛素递送与体内血糖调节的无酶、硼砂交联微针的系统性开发与表征DOI: 10.3390/pharmaceutics17121578 Pharmaceutics IF: 05.500Volume 17, Issue 12No.209Inulin Reverses Intestinal Mrp2 Downregulation in a Diet-Induced Obesity Mouse Model: Role of Intestinal Microbiota as a Pivotal Modulator菊粉逆转饮食诱导肥胖小鼠模型中肠道Mrp2下调：肠道微生物群作为关键调节因子的作用DOI: 10.3390/pharmaceutics17121575 Pharmaceutics IF: 05.500Volume 17, Issue 12No.210Nanoparticle-Based Oral Insulin Delivery: Challenges, Advances, and Future Directions基于纳米颗粒的口服胰岛素递送：挑战、进展与未来方向DOI: 10.3390/pharmaceutics17121563 Pharmaceutics IF: 05.500Volume 17, Issue 12No.211In Silico Hypothesis Testing in Drug Discovery: Using Quantitative Systems Pharmacology Modeling to Evaluate the Therapeutic Value of Proinsulin Conversion to Insulin Therapy for Type 2 Diabetes Mellitus药物发现中的计算机模拟假设检验：使用定量系统药理学模型评估胰岛素原转化为胰岛素疗法对2型糖尿病的治疗价值DOI: 10.3390/pharmaceutics17121522 Nutrients IF: 05.000Volume 17, Issue 24No.212Mice Condition Cephalic Insulin Responses to the Flavor of Different Laboratory Chows小鼠对不同实验室饲料风味建立头期胰岛素反应DOI: 10.3390/nu17243880 Nutrients IF: 05.000Volume 17, Issue 24No.213Metabolic and Neuroenergetic Effects of Intranasal Vitamin C Application in the Human Brain鼻内应用维生素C对人脑代谢与神经能量学的影响DOI: 10.3390/nu17243875 Nutrients IF: 05.000Volume 17, Issue 24No.214Prediction of Postprandial Blood Glucose Variability Using Machine Learning in Frequent Insulin Injection Therapy with a Simplified Carbohydrate Counting Model使用机器学习和简化碳水化合物计数模型预测频繁胰岛素注射治疗中的餐后血糖变异性DOI: 10.3390/nu17243832 Nutrients IF: 05.000Volume 17, Issue 24No.215Gut Microbiota and Metabolic Modulation by Slow-Release Protein Substitutes in Phenylketonuria: Findings from the PREMP Study缓释蛋白质替代品对苯丙酮尿症患者肠道微生物群及代谢的调节作用：PREMP研究结果DOI: 10.3390/nu17243829 Micromachines IF: 03.000Volume 16, Issue 12No.216Pump-Free Insulin Delivery via an SLA-Printed Hollow Microneedle Patch with an Integrated Self-Sealing Reservoir基于SLA打印中空微针贴片结合自密封储库的无泵胰岛素递送系统DOI: 10.3390/mi16121322 Medicina IF: 02.400Volume 61, Issue 12No.217The Prevalence of H. pylori Among Jordanian Type 2 Diabetic Patients and Its Association with ABO Blood Group幽门螺杆菌在约旦2型糖尿病患者中的流行情况及其与ABO血型的关联DOI: 10.3390/medicina61122167 Medicina IF: 02.400Volume 61, Issue 12No.218Can Insulin Drops Accelerate Corneal Healing After Corneal Cross-Linking? A Preliminary Case Series胰岛素滴眼液能加速角膜交联术后的角膜愈合吗？一项初步病例系列研究DOI: 10.3390/medicina61122101 Nutrients IF: 05.000Volume 17, Issue 24No.219Nutrient-Induced Remodeling of the Adipose-Cardiac Axis: Metabolic Flexibility, Adipokine Signaling, and Therapeutic Implications for Cardiometabolic Disease营养素诱导的脂肪-心脏轴重塑：代谢灵活性、脂肪因子信号与心脏代谢疾病的治疗启示DOI: 10.3390/nu17243945 Nutrients IF: 05.000Volume 17, Issue 24No.220C. cochlearium 2316 Ameliorates High-Fat Diet-Induced Obesity and Metabolic Syndrome Risk Factors via Enhanced Energy Expenditure and Glucose HomeostasisC. cochlearium 2316通过增强能量消耗和血糖稳态改善高脂饮食诱导的肥胖与代谢综合征风险因素DOI: 10.3390/nu17243848 Medicina IF: 02.400Volume 61, Issue 12No.221A Comparison of Periodontal Health in Elderly Individuals with and Without Metabolic Syndrome: A Retrospective Study代谢综合征与老年牙周健康状况比较：一项回顾性研究DOI: 10.3390/medicina61122200 Medicina IF: 02.400Volume 61, Issue 12No.222Nutrition Counseling Frequency and Telehealth Integration on Cardiometabolic Outcomes in Metabolic Syndrome: A Randomized Controlled Trial in Turkey营养咨询频率与远程医疗整合对代谢综合征心脏代谢结果的影响：一项土耳其随机对照试验DOI: 10.3390/medicina61122124 Medicina IF: 02.400Volume 61, Issue 12No.223Prevalence of Cardiovascular-Kidney-Metabolic (CKM) Syndrome in Lithuanian Adults: Insights from a Nationwide Real-World Study Using Electronic Health Records立陶宛成年人心血管-肾脏-代谢综合征患病率：基于全国电子健康记录的真实世界研究见解DOI: 10.3390/medicina61122106 Investig Clin Urol IF: 02.100Volume 67, Issue 1No.224Metabolic syndrome and its components as independent risk factors for nocturia: A national cross-sectional analysis代谢综合征及其组分作为夜尿症的独立危险因素：一项全国性横断面分析DOI: 10.4111/icu.20250261 Case Rep Oncol Med IF: 00.600Volume 2025, Issue No.225Hypertriglyceridemia-Induced Acute Pancreatitis Associated with Ruxolitinib for Hemophagocytic Lymphohistiocytosis: A Case Report鲁索替尼治疗噬血细胞性淋巴组织细胞增生症相关的高甘油三酯血症诱发急性胰腺炎：一例病例报告DOI: 10.1155/crom/7271334 Veterinary World IF: 02.000Volume 18, Issue 11No.226Integrative metabolomics and hormonal profiling reveal biomarkers of milk yield efficiency in Sapera dairy goats under tropical conditions整合代谢组学与激素谱分析揭示热带条件下Sapera奶山羊产奶效率的生物标志物DOI: 10.14202/vetworld.2025.3594-3606 Molecules IF: 04.600Volume 30, Issue 24No.227Design and Biological Evaluation of Monoterpene-Conjugated (S)-2-Ethoxy-3-(4-(4-hydroxyphenethoxy)phenyl)propanoic Acids as New Dual PPARα/γ Agonists单萜共轭的(S)-2-乙氧基-3-(4-(4-羟基苯乙氧基)苯基)丙酸作为新型双重PPARα/γ激动剂的设计与生物活性评估DOI: 10.3390/molecules30244775 Molecules IF: 04.600Volume 30, Issue 24No.228Protective Metabolic Effects of Chickpea Sprout Against Obesity-Induced Insulin Resistance and Hypoestrogenism in Rats鹰嘴豆芽对肥胖诱导的胰岛素抵抗及低雌激素血症大鼠模型的保护性代谢效应DOI: 10.3390/molecules30244673 Nutrients IF: 05.000Volume 17, Issue 24No.229Refining MASLD Phenotypes: Clinical, Metabolic, and Elastographic Differences Between Adipose Tissue Dysfunction and Obesity-Driven Disease细化MASLD表型：脂肪组织功能障碍与肥胖驱动疾病之间的临床、代谢与弹性成像差异DOI: 10.3390/nu17243940 Nutrients IF: 05.000Volume 17, Issue 24No.230Opuntia dillenii as a Nutraceutical and Dietary Resource for Disease Prevention and Management: A Systematic ReviewOpuntia dillenii作为营养保健品与膳食资源在疾病预防和管理中的作用：一项系统综述DOI: 10.3390/nu17243915 Nutrients IF: 05.000Volume 17, Issue 24No.231Redox Response in Postoperative Metabolic and Bariatric Surgery: New Insights into Cardiovascular Risk Markers代谢和减重术后的氧化还原反应：心血管风险标志物的新见解DOI: 10.3390/nu17243821 Medicina IF: 02.400Volume 61, Issue 12No.232Impact of Obstructive Sleep Apnea-Hypopnea Syndrome Severity on Heart Rate Variability and QTc Interval in Hypertensive Patients阻塞性睡眠呼吸暂停低通气综合征严重程度对高血压患者心率变异性及QTc间期的影响DOI: 10.3390/medicina61122221 Medicina IF: 02.400Volume 61, Issue 12No.233Cardiometabolic Risk Factors Among Adults in a Rural Amazonian Peruvian Population秘鲁农村亚马逊地区成年人心血管代谢风险因素DOI: 10.3390/medicina61122206 Pharmaceuticals IF: 04.800Volume 18, Issue 12No.234Rosuvastatin Versus Atorvastatin for Cardiovascular Disease Risk in Patients with Type 2 Diabetes: A Korean Cohort Study瑞舒伐他汀与阿托伐他汀对2型糖尿病患者心血管疾病风险的比较：一项韩国队列研究DOI: 10.3390/ph18121860 Nigerian Medical journalVolume 66, Issue 4No.235Assessment of Peripheral Arterial Disease among Type 2 Diabetes Patients in Calabar, Nigeria尼日利亚卡拉巴尔2型糖尿病患者外周动脉疾病评估DOI: 10.71480/nmj.v66i4.560 Medicina IF: 02.400Volume 61, Issue 12No.236Serum Trimethylamine N-Oxide Levels Are Associated with Peripheral Artery Disease in Patients with Type 2 Diabetes Mellitus血清三甲胺N-氧化物水平与2型糖尿病患者的周围动脉疾病相关DOI: 10.3390/medicina61122243 JEADV IF: 08.000Ahead of Print.No.237French guidelines on systemic treatments for moderate-to-severe psoriasis in adults: Update 2025法国成人中重度银屑病系统治疗指南：2025年更新DOI: 10.1111/jdv.70263 Front Mol Biosci IF: 04.000Volume 12, Issue No.238Retraction: Circular ribonucleic acid circFTO promotes angiogenesis and impairs blood-retinal barrier via targeting the miR-128-3p/Thioredoxin interacting protein axis in diabetic retinopathy撤稿：环状RNA circFTO通过靶向miR-128-3p/硫氧还蛋白相互作用蛋白轴促进血管生成并损害血-视网膜屏障：糖尿病视网膜病变研究DOI: 10.3389/fmolb.2025.1727243 Pharmaceutics IF: 05.500Volume 17, Issue 12No.239Enhanced Ocular Delivery of Epalrestat Using Nanostructured Lipid Carrier Laden Soft Contact Lens利用载有纳米结构脂质载体的软性接触镜增强依帕司他的眼部递送DOI: 10.3390/pharmaceutics17121515 Medicina IF: 02.400Volume 61, Issue 12No.240Proliferative Diabetic Retinopathy in Young-Onset Type 1 Diabetes in Croatia: Risk Factors and a Predictive Economic Model for National Screening克罗地亚年轻起病1型糖尿病患者中增生性糖尿病视网膜病变的风险因素及全国筛查预测经济模型DOI: 10.3390/medicina61122168 BMC infectious diseases IF: 03.000Volume 25, Issue 1No.241Remdesivir safety and clinical outcomes in pediatric COVID-19: a retrospective study瑞德西韦在儿科COVID-19患者中的安全性与临床结局：一项回顾性研究DOI: 10.1186/s12879-025-12155-z 179 Diabetes Mellitus(DM) 糖尿病 120 Obesity 肥胖症 71 Insulin 胰岛素 31 Type 2 diabetes mellitus(T2DM) 2型糖尿病 18 Metabolic Syndrome 代谢综合征 11 Hypoglycemic Agents 降糖药 10 Diabetic Retinopathy 糖尿病视网膜病 9 Metformin 二甲双胍 8 Diabetic Foot 糖尿病足 7 Diabetic Kidney Disease(DKD) 糖尿病肾脏病 6 Gestational Diabetes Mellitus(GDM) 妊娠糖尿病 5 Glucagon-Like Peptide-1 Receptor Agonists(GLP-1RA) 胰高血糖素样肽-1受体激动剂 4 Type 1 diabetes mellitus(T1DM) 1型糖尿病 2 Liraglutide 利拉鲁肽 2 Semaglutide 司美格鲁肽 2 Diabetic Neuropathies 糖尿病性神经病变 2 gamma-Aminobutyric Acid(GABA) γ-氨基丁酸 2 Sodium-Glucose Transporter 2 Inhibitors(SGLT-2i) 钠-葡萄糖协同转运蛋白2抑制剂 2 Dapagliflozin 达格列净 2 Diabetes Complications 糖尿病并发症 2 Diabetic acidosis 糖尿病性酸中毒 1 Dulaglutide 度拉糖肽 1 Gastrointestinal lipase inhibitor 胃肠道脂肪酶抑制剂 1 Orlistat 奥利司他 1 Diabetes mellitus in pregnancy 妊娠期糖尿病 1 Dipeptidyl-Peptidase IV Inhibitors(DPP-4i) 二肽基肽酶-4抑制剂 1 Vildagliptin 维格列汀 1 Gabapentin 加巴喷丁编辑：天纳乾坤审校：天纳乾坤

临床结果

2026-01-01

·情绪障碍笔记

双相障碍的未来药物治疗：新趋势与个体化方案

摘要背景：双相情感障碍（BD）是一种慢性致残性精神疾病，以躁狂、轻躁狂和抑郁反复发作为特征。尽管心境稳定剂、抗精神病药物和抗抑郁药物已广泛应用于临床，但由于症状控制不完全、药物不良反应及高复发率等问题，其长期管理仍面临挑战。方法：本文采用叙述性综述方法，旨在综合阐述双相障碍药物治疗的新兴趋势与未来发展方向。结果：双相障碍的未来药物治疗将趋向精准医疗，通过利用遗传学、生物标志物和神经影像学的最新进展指导个体化治疗策略。新型药物研发也将针对以往研究不足的机制，如炎症、线粒体功能障碍、昼夜节律紊乱和谷氨酸能系统失调。生理内表型（如免疫-代谢特征、昼夜节律和应激反应性）正成为有前景的转化工具，可用于定制治疗方案并降低相关躯体共病发生率和死亡率。对双相障碍异质性纵向病程（包括慢性混合状态、长期抑郁发作或间歇性躁狂阶段）的认知，凸显了临床分期模型在指导药物治疗策略和生物标志物研究方面的重要价值。昼夜节律紊乱及相关时型特征进一步推动了个体化时辰治疗策略的发展。基于个体生物节律的新型时辰疗法（如唾液锂浓度传感器等创新监测策略）正在重塑未来治疗格局。抗炎药物、神经类固醇及调节氧化应激的化合物已成为具有潜力的候选治疗方案。此外，针对双相障碍病理生理中特定生物通路的药物（如N-甲基-D-天冬氨酸（NMDA）受体调节剂、磷酸二酯酶抑制剂和神经肽等）也正处于研究阶段。结论：药物基因组学的进步将使临床医生能够预测个体患者的药物反应和耐受性，最大限度减少试错式处方。未来治疗模式还将整合数字疗法，实现药物治疗与远程监测及数据驱动调整的有机结合。最终，创新药物疗法与个体化策略的整合应用，有望提高双相障碍治疗效能、减少不良反应并改善长期预后，从而引领精准精神病学的新纪元。该论文原文长达33页，限于篇幅，只简要介绍主要内容，感兴趣者，可自行查看原文。一、核心摘要与背景背景：双相情感障碍（BD）是一种慢性、高致残性的精神疾病，其特征是躁狂、轻躁狂和抑郁反复发作。当前基于心境稳定剂、抗精神病药物和抗抑郁药物的长期治疗效果有限，存在症状控制不完全、不良反应多和高复发率等挑战。未来方向：双相障碍的药物治疗正朝着精准精神病学的方向发展。未来的治疗策略将深度融合遗传学、生物标志物、神经影像学及数字健康技术，以实现个体化治疗。新兴药物靶点包括炎症、线粒体功能障碍、昼夜节律紊乱和谷氨酸能系统失调等。二、对双相障碍病理生理学的新认识未来的药物治疗革新建立在对疾病机制更深入的理解之上：遗传与表观遗传学：全基因组关联研究（GWAS）已发现多个与BD相关的基因位点（如CACNA1C, ANK3）。药物基因组学测试（如CYP450酶代谢分型）有助于预测药物反应和不良反应，指导临床用药。神经炎症与免疫失调：慢性应激和情绪发作会导致神经炎症、小胶质细胞激活（M1/M2表型失衡）和氧化应激，这与疾病的“神经进展”（即疾病随反复发作而加重）相关。线粒体功能障碍与氧化应激：大脑能量代谢异常、抗氧化防御系统削弱是BD的核心病理环节，导致神经元可塑性受损。神经递质系统失衡：除传统的单胺类递质外，谷氨酸能系统过度兴奋、GABA能系统功能不足等机制日益受到重视。三、新兴药物治疗策略与药物类别抗炎与免疫调节剂目标：调节IL-6, TNF-α等促炎细胞因子。代表药物：米诺环素、阿司匹林、塞来昔布、吡格列酮、英夫利昔单抗（抗TNF-α抗体）。部分传统药物（如锂盐、喹硫平）也显示出免疫调节特性。挑战：疗效存在异质性，未来需针对具有特定炎症生物标志物的患者亚群进行治疗。线粒体功能增强剂与氧化应激调节剂目标：改善细胞能量代谢，减少氧化损伤。代表药物：N-乙酰半胱氨酸（NAC）、辅酶Q10、PPARγ激动剂（如吡格列酮）、褪黑素。这类药物通常起效较慢，多作为辅助治疗。谷氨酸能调节剂目标：快速抗抑郁，尤其针对难治性抑郁。代表药物：氯胺酮（及其S-异构体艾氯胺酮）显示出快速（数小时内）的抗抑郁和抗自杀效果，但疗效持续时间短，存在滥用和转躁风险。神经甾体目标：调节GABA-A受体，发挥快速抗抑郁和抗焦虑作用。代表药物：Zuranolone（SAGE-217），一种口服的别孕烯醇酮类似物，为短期疗程治疗带来了希望。迷幻药与新型快速抗抑郁药目标：通过5-HT2A受体激动等方式打破僵化的负面思维模式。代表药物：裸盖菇素（Psilocybin）在严格控制的心理治疗辅助下显示出潜力。大麻二酚（CBD）也在研究中。重要警示：这类药物在BD患者中引发躁狂转换的风险较高，安全性是首要关切，目前仍以研究为主。表观遗传药物目标：通过调节DNA甲基化、组蛋白修饰来纠正基因表达异常。代表药物：丙戊酸钠本身具有组蛋白去乙酰化酶抑制活性。更特异性的表观遗传药物尚在临床前研究阶段。时间治疗策略目标：根据患者的个体化生物节律（昼夜节律）来调整给药时间，以增强疗效、减少副作用。方法：利用锂盐、褪黑素受体激动剂（如雷美替胺）等药物调节节律，并结合规律的社会作息（如人际与社会节律疗法IPSRT）。四、数字健康与未来治疗监测可穿戴设备与症状监测：通过智能手表等设备持续监测心率变异性、睡眠、活动水平等生理数据，利用算法早期预警情绪发作。数字应用程序：通过主动（患者自评）和被动（手机使用模式、语音分析）数据收集，实现实时病情追踪和个性化反馈。锂盐监测传感器：新兴的唾液锂传感器技术有望实现无创、居家的血锂浓度实时监测，极大提高用药安全性和依从性。人工智能（AI）的应用：AI能整合临床、基因组、数字和行为数据，构建预测模型，为医生提供决策支持，实现真正的精准处方。五、与心理治疗和生活方式干预的整合未来治疗强调多模式整合，将药物治疗与心理社会干预相结合：心理治疗：认知行为疗法（CBT）、人际与社会节律疗法（IPSRT）、家庭聚焦疗法（FFT）等被证明能有效预防复发、改善社会功能。生活方式干预：针对睡眠（CBT-I）、饮食（抗炎饮食、Omega-3补充）、规律运动（增加脑源性神经营养因子BDNF）的干预，对稳定情绪和改善整体健康至关重要。六、结论与未来展望未来双相障碍的治疗范式将发生根本性转变：从一刀切转向个体化、精准化，从单纯症状控制转向促进功能恢复和生活质量。成功的关键在于：跨学科融合：将药理学创新、数字技术和生物标志物研究深度结合。生物表型分层：未来的临床试验需基于特定的生物标志物（如炎症水平、节律类型）招募患者，而非宽泛的诊断分类。关注长期安全性与功能结局：需要更多长期研究来评估新疗法的持久性、安全性和对患者整体生活的改善。总之，双相障碍的药物治疗正在进入一个由生物学洞察和技术创新驱动的精准医学新时代，旨在为每位患者提供更有效、更安全、更个性化的管理方案。

2025-12-31

·今日头条

超越反复与恐惧：强迫症治疗的新版图

在针对“污染怕脏”型强迫症患者的研究中，当暴露疗法与精准的经颅电刺激同步进行，短短8次治疗就让超过六成患者迎来转机。强迫症作为一种以侵入性思维和重复性行为为特征的慢性精神障碍，常使患者陷入巨大的痛苦。尽管传统的药物与认知行为疗法是主流，但部分患者疗效有限，且存在起效慢、治疗资源紧张等挑战。如今，随着脑科学、药理学和数字技术的突破，强迫症的治疗正迎来一场静默的革命。新的疗法正从 “增强现有疗法效率” 、 “开创全新作用机制” 和对难治病例的“终极干预” 等多个维度展开，为患者带来了前所未有的希望。 01 联合新范式：当心理治疗遇上神经调控心理治疗，特别是暴露与反应预防疗法，是强迫症的一线选择，但并非对所有人都足够有效。科学家开始思考：能否直接对大脑进行温和调控，为心理治疗“铺路搭桥”？ 2025年，上海的研究团队给出了肯定的答案。他们创新性地将高精度经颅直流电刺激与标准的暴露与反应预防疗法同步进行。在这项研究中，当以“怕脏”为困扰的患者在治疗师指导下接触“污染”物品并努力克制清洁行为时，一种无痛、微弱的电流也同步作用于他们大脑的内侧前额叶区域。这个区域与行为的认知控制和调节密切相关。研究结果显示，这种“双管齐下”的联合疗法效果显著。仅 4次治疗后，联合治疗组症状改善程度就明显优于单纯心理治疗组。完成 8次治疗后，联合组的有效率达到了 61.5% ，几乎是单纯心理治疗组的两倍。这标志着“神经调控-心理治疗”协同干预新路径的诞生。 02 治疗新形态：数字技术与药物创新治疗的变革不仅在于联合，也在于形态的创新与机制的拓荒。数字化认知行为疗法应运而生。通过专门的计算机程序或智能手机应用，患者可以在治疗师的远程指导下，甚至部分自主地完成认知行为治疗练习。这种方式极大地提高了治疗的可及性，尤其有助于解决专业治疗师资源不足的困境。在药物研发领域，科学家们也在寻找超越传统药物的全新武器。曲鲁利唑是一种具有全新作用机制的在研药物，它旨在调节大脑中的谷氨酸系统——这是与思维、学习和记忆相关的关键神经递质系统。目前，它作为辅助治疗药物的三期临床试验已在全球多国（包括中国的多家顶尖医院）展开，为难治性患者带来了新的期待。更前沿的探索来自裸盖菇素。一项2025年的初步研究发现，单次服用 10毫克剂量的裸盖菇素，能在一周内快速缓解部分患者的强迫症状，且效果似乎独立于情绪的改善。这为开发起效更快的“按需治疗”模式提供了令人兴奋的全新思路。 03 终极新武器：精准的脑深部电刺激对于大约 10%-20% 的难治性强迫症患者，即使经过充分、规范的传统治疗，症状依然严重。脑深部电刺激，为这部分患者提供了最后的“终极武器”。这是一种神经外科手术，医生将细微的电极精确植入大脑深部特定的异常神经环路中（如内囊前肢、伏隔核等靶点）。植入的脉冲发生器会持续发放微弱电脉冲，调控这些环路的异常活动，从而达到缓解症状的目的。该技术具有微创、可逆、可调节的优势。术后，医生可以根据患者的反应远程调整刺激参数，以追求最佳疗效并最小化副作用。正是基于其明确的疗效和可靠的安全性，国际上已批准其用于治疗难治性强迫症，我国也于2024年发布了首个专家共识以规范其临床应用。前沿研究正在探索更智能的 “闭环”脑深部电刺激。这种新一代系统不仅能发放刺激，还能通过同一电极实时监测患者大脑的特定电活动信号。未来，它有望在识别出强迫思维或冲动即将出现的“脑电特征”时，自动触发精准的干预刺激，实现真正的个性化、智能化治疗。 04 未来新图景：从精准干预到整合治疗纵观这些进展，强迫症治疗的未来图景正在从“单一疗法、试错治疗”向 “精准干预、整合治疗” 深刻转变。未来的治疗路径将更加清晰和个性化：对于大多数患者，数字化认知行为治疗或增强版的联合疗法可能成为高效、便捷的一线选择。对于疗效不佳者，全新作用机制的药物将提供更多后备选择。对于真正的难治性患者，脑深部电刺激等神经调控技术将成为重要的拯救性治疗方案。贯穿始终的核心是 “精准” 。无论是通过脑电寻找疗效预测标志物，还是根据个体大脑结构差异优化电流刺激方案，抑或是研发能识别特定脑电信号的闭环设备，目标都是为每一位患者“量体裁衣”，实现疗效最大化。结语从无创的联合调控到前沿的闭环手术，强迫症的治疗正在经历一场深刻的技术革命。这些新疗法不仅带来了更高的疗效和更广的覆盖，更重要的是，它们正将治疗从单纯控制外在行为，推向直接调节内在神经环路的根源。它们为患者传递出一个强有力的信号：即使是最顽固的强迫思维与行为，也终将在不断进步的医学智慧面前，找到解锁的钥匙。希望，正根植于对大脑日益深入的理解和日新月异的技术创新之中。如果你对其中某一种特定疗法（例如更适合初诊患者的数字化治疗，或针对难治病例的脑深部电刺激的详细流程）想了解更多细节，我很乐意为你提供进一步的解释。

临床3期临床成功临床结果

100 项与裸盖菇素相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	裸盖菇素	-	DB11664

研发状态

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适应症	最高研发状态	国家/地区	公司	日期
重度抑郁症	临床3期	美国	Usona Institute	2024-03-13
难治性抑郁症	临床3期	美国	Compass Pathways Plc	2023-01-19
腰痛	临床2期	美国	Yale University	2026-06-01
周围神经系统疾病	临床2期	美国	The University of Texas MD Anderson Cancer Center	2026-05-04
口吃	临床2期	美国	NYU Langone Health	2026-01-15
兴奋剂滥用	临床2期	-	Filament Health Corp.	2025-01-01
阿片滥用	临床2期	-	Filament Health Corp.	2024-12-01
晚期癌症	临床2期	美国	The University of Texas MD Anderson Cancer Center	2024-04-16
肠易激综合征	临床2期	美国	Tryp Therapeutics, Inc.	2024-01-17
边缘性人格障碍	临床2期	美国	Usona Institute	2023-11-01

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临床结果

适应症

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT04950608 (PATH, CTgov)	临床2期	疾病进展 \| 晚期癌症	15	Psilocybin	鏇鹹糧顧夢醖觸鑰蓋壓 = 艱範築鏇鬱構觸選積醖範壓襯構衊鹹簾遞願醖 (築構蓋鬱觸壓淵齋廠鬱, 獵顧夢遞簾顧鏇鏇膚網 ~ 鏇齋積壓製築顧顧艱鏇) 更多	-	2025-09-02
NCT04424225 (CTgov)	临床1期	致幻 \| 知觉障碍 \| 视觉抑制	10	Psilocybin (Psilocybin)	構顧鬱齋淵網鬱膚鑰齋(選廠顧觸觸糧鹹鹽觸衊) = 膚廠夢艱淵壓觸膚範鏇淵廠獵獵製齋鑰鏇艱簾 (獵觸觸鹹積築廠憲淵鑰, .11731) 更多	-	2025-06-27
NCT04424225 (CTgov)	临床1期	致幻 \| 知觉障碍 \| 视觉抑制	10	Niacin (Niacin)	構顧鬱齋淵網鬱膚鑰齋(選廠顧觸觸糧鹹鹽觸衊) = 積淵網蓋餘簾顧窪獵糧淵廠獵獵製齋鑰鏇艱簾 (獵觸觸鹹積築廠憲淵鑰, .04398) 更多	-	2025-06-27
NCT05312151 (CTgov)	临床2期	创伤后应激障碍	22	Psilocybin	醖糧鹹餘範蓋夢夢製鬱 = 淵鑰壓觸壓窪鏇繭觸願製鑰蓋獵繭壓觸壓餘淵 (築窪鹹觸遞廠夢觸遞壓, 築積鑰蓋鹹範積鏇簾繭 ~ 衊製範艱鏇鑰膚壓積蓋) 更多	-	2025-06-13
NCT05847686 (CTgov)	临床1/2期	转移性肿瘤 \| 转移性实体瘤 \| 血液肿瘤 ... 更多	55	Counseling+Psilocybin	積選鬱獵網遞構繭餘鏇 = 製範壓壓襯積遞獵蓋網夢齋鹹繭願顧願廠鏇觸 (築簾顧餘淵鑰艱蓋製獵, 膚構淵網餘製衊鏇鹽淵 ~ 窪廠齋製醖壓壓夢廠構) 更多	-	2025-04-30
NCT05128162 (CTgov)	临床2期	纤维肌痛	17	Psilocybin	醖壓淵鬱襯願齋淵築憲(衊壓廠齋窪獵觸衊餘廠) = 願鹹鹽蓋蓋襯齋積餘獵蓋艱窪願淵鹹築齋憲網 (簾選鹹範願鏇糧網鏇網, 窪選簾顧觸鹽艱醖遞積 ~ 顧鹽鏇鹽憲繭觸積襯鹹) 更多	-	2025-04-16
NCT04141501 (Pubmed \| EClinicalMedicine)	临床2期	酒精使用障碍	37	Psilocybin (25 mg)	艱蓋積淵範淵餘壓鹽鹹(觸壓餘獵衊積衊繭壓膚) = 夢鏇鏇糧構夢憲餘簾艱選餘餘鏇繭膚顧膚憲膚 (廠網積觸築顧淵淵繭廠, 14.31 ~ 19.29) 更多	不佳	2025-04-01
NCT04141501 (Pubmed \| EClinicalMedicine)	临床2期	酒精使用障碍	37	Placebo (mannitol)	艱蓋積淵範淵餘壓鹽鹹(觸壓餘獵衊積衊繭壓膚) = 淵獵襯鏇顧構構顧膚選選餘餘鏇繭膚顧膚憲膚 (廠網積觸築顧淵淵繭廠, 10.97 ~ 16.63) 更多	不佳	2025-04-01
NCT05163496 (CTgov)	临床3期	新冠肺炎后遗症 \| 职业倦怠 \| 创伤后应激障碍	30	Psilocybin (Psilocybin Arm)	網願築築窪窪夢壓醖廠(獵遞膚餘築憲鏇膚齋觸) = 選製淵築夢鑰鬱鬱製積鹽鏇顧淵憲觸簾構獵膚 (夢築憲製蓋淵觸鏇鑰獵, 7.84) 更多	-	2025-03-18
NCT05163496 (CTgov)	临床3期	新冠肺炎后遗症 \| 职业倦怠 \| 创伤后应激障碍	30	Active placebo (Placebo)	網願築築窪窪夢壓醖廠(獵遞膚餘築憲鏇膚齋觸) = 餘遞積鑰觸築衊範鏇網鹽鏇顧淵憲觸簾構獵膚 (夢築憲製蓋淵觸鏇鑰獵, 7.32) 更多	-	2025-03-18
NCT04718792 (Company_Website \| Pubmed) 人工标引	临床2期	酒精使用障碍	10	PEX010	蓋夢醖鹽積襯襯糧繭獵(鏇蓋選鹹鹹鹽構範廠簾) = 構顧衊積範鏇餘網憲築醖顧網憲選繭壓廠餘鑰 (範簾製淵憲壓網蓋餘艱, −61.1 ~ −13.9) 更多	积极	2025-03-17
NCT04433858 (Pubmed \| J Affect Disord)	临床2期	难治性抑郁症	15	Psilocybin 25 mg	鏇醖廠襯淵鹹鏇願餘窪(憲糧鏇糧窪構製憲繭觸) = 衊觸願繭鏇範鬱願製壓顧遞壓衊願窪壓簾艱壓 (積觸膚顧觸觸製廠顧範 ) 更多	积极	2025-01-01
NCT03429075 (Psilodep-RCT \| COMP360, CTgov)	临床2期	重度抑郁症	59	Psilocybin + Placebo (Psilocybin)	憲鬱蓋蓋簾繭選願顧艱(蓋鏇鬱淵選鹹糧齋糧觸) = 窪鹽鹹膚齋顧選構醖遞壓範襯鹽繭觸觸憲願顧 (壓鏇廠遞餘醖醖膚夢艱, 0.45) 更多	-	2024-10-24
NCT03429075 (Psilodep-RCT \| COMP360, CTgov)	临床2期	重度抑郁症	59	Escitalopram+Psilocybin (Escitalopram)	憲鬱蓋蓋簾繭選願顧艱(蓋鏇鬱淵選鹹糧齋糧觸) = 醖製範鹽襯襯窪襯網遞壓範襯鹽繭觸觸憲願顧 (壓鏇廠遞餘醖醖膚夢艱, 0.62) 更多	-	2024-10-24