预约演示
更新于：2024-12-26
Chlorpheniramine Maleate
马来酸氯苯那敏
更新于：2024-12-26
概要
基本信息
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C20H23ClN2O4 |
InChIKeyDBAKFASWICGISY-BTJKTKAUSA-N |
CAS号113-92-8 |
关联
33
项与 马来酸氯苯那敏 相关的临床试验CTRI/2024/07/071575
Effect of single dose Bilastine, desloratadine, chlorpheniramine and placebo on psychomotor functions in healthy human volunteers: A double blind placebo controlled cross over design clinical Trial - NIL
IRCT20230726058930N4
Comparison of Effect of ondansetron And Chlorpheniramine in controlling nausea in adults in emergency department
NCT05858216
First-generation OTC Antihistamine Use and Voice Function: A Preliminary Study
100 项与 马来酸氯苯那敏 相关的临床结果
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100 项与 马来酸氯苯那敏 相关的转化医学
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100 项与 马来酸氯苯那敏 相关的专利（医药）
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2,474
项与 马来酸氯苯那敏 相关的文献（医药）2024-12-16JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
Effects of anthranilic diamide insecticides on metamorphosis in the common toad
Rhinella arenarum
(Hensel, 1867) at concentrations found in aquatic environments
Article
作者: Brodeur, Julie Céline ; Peña, Shirley Vivian Daniela Fonseca
Anthranilic diamides (AD) are a modern class of insecticides used as alternatives to pyrethroids and neonicotinoids, particularly against lepidopteran pests. Despite their widespread use and presence in surface waters, little is known regarding their effects on amphibians. The aim of this study was to examine the effects of environmentally-relevant concentrations of AD insecticides chlorantraniliprole (CHLO) and cyantraniliprole (CYAN) on metamorphosis of the toad Rhinella arenarum. Tadpoles were exposed to CHLO or CYAN at concentrations ranging from 5 and 5000 µg/L from stage 27 until metamorphosis completion. Both insecticides produced a non-monotonic acceleration of the time required for individuals to progress through development and a decrease in the proportion of individuals completing metamorphosis, although a delay in metamorphosis was also observed at 5 µg/L of CHLO. Snout-vent length and body weight of metamorphosed toads were not markedly affected by either insecticide. CHLO was more toxic than CYAN, with a lowest observed effect concentration (LOEC) for CHLO on time to metamorphosis defined as 5 µg/L compared to 5000 µg/L for CYAN. The LOEC for reduced metamorphic success defined as 50 µg/L for CHLO compared to 500 µg/L for CYAN. As most effects occurred after stage 39, when metamorphosis depends upon thyroid hormones, it is conceivable that that AD insecticides act as endocrine disruptors. These findings suggest that contamination of surface waters with CHLO and CYAN may disrupt amphibian development in the wild and warrant further research to investigate the possibility of endocrine-disruption by ADs.
2024-12-01EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
Preventive effects of first-generation antihistamine on emergence agitation or delirium: a systematic review
Review
作者: Noritake, Yumi ; Kotake, Kazumasa ; Matsunuma, Satoru ; Kawakami, Yasuhiro ; Kitamura, Naoya
PURPOSE:
The effects of first-generation antihistamines in preventing postoperative emergence agitation or delirium are unclear. Determining the postoperative effects of first-generation antihistamines may provide important insights into the management of patient safety. Therefore, we performed a systematic review of randomized controlled trials (RCTs) evaluating the efficacy and safety of postoperative first-generation antihistamines.
METHODS:
Patients who used first-generation antihistamines in the intensive care unit or operating room were included. Primary outcomes were assessed postoperative emergence agitation or delirium with binary and continuous variables. The secondary outcome was any adverse event.
RESULTS:
Nine studies were included. The frequency of postoperative emergence agitation, measured using binary variables, tended to be lower in patients receiving chlorpheniramine or diphenhydramine than those receiving saline. However, evaluation using the Richmond Agitation-Sedation Scale as a continuous variable revealed that only chlorpheniramine was effective at lowering postoperative emergence agitation. Only one study assessed delirium but found no benefit of first-generation antihistamines. Adverse events for first-generation antihistamines did not differ from that of other drugs.
CONCLUSION:
Our results provide limited evidence that some first-generation antihistamines may prevent postoperative emergence agitation and are safe. To further verify this possibility, new RCTs with clear and universal assessment criteria for postoperative emergence agitation or delirium should be conducted.
2024-12-01CURRENT MEDICAL RESEARCH AND OPINION
Pharmacology of chlorphenamine and pseudoephedrine use in the common cold: a narrative review
Review
作者: Douhard, Romain ; Milon, Jean-Yves ; Pegahi, Rassa ; Humbert, Philippe
The common cold is the most frequent upper respiratory viral infection. Although benign, it represents a high socioeconomic burden. Many over-the-counter drugs are available to manage the symptoms of this condition, with antihistamines and vasoconstrictors being the most widely used. This review aimed to compare the potential mechanisms underlying the efficacy and safety of chlorphenamine and pseudoephedrine, the most commonly used agents in these two classes of drugs, and provide a useful perspective to impact appropriate decisions when considering these options for symptomatic common cold treatment. To conduct a comprehensive analysis, we systematically reviewed the use of pseudoephedrine and chlorphenamine using various databases, including MEDLINE, Google Scholar, Scopus, and Embase. We also perused the bibliographies of relevant articles and the EudraVigilance database. The findings suggest that pseudoephedrine may offer specific benefits in rapidly alleviating nasal congestion in the short term. Chlorphenamine appears to exhibit a higher degree of efficacy in alleviating rhinorrhea and other specific cold symptoms compared to pseudoephedrine. Pharmacovigilance data and case report reviews showed that pseudoephedrine may induce a higher incidence of less common but potentially life-threatening adverse effects compared to chlorphenamine. We concluded that antihistamine drugs exhibit a more favorable benefit/risk profile than vasoconstrictors for treating symptomatic common colds.
100 项与 马来酸氯苯那敏 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 血管水肿 | 日本 | 2007-08-31 | |
| 血管性水肿 | 日本 | 1984-07-20 | |
| 湿疹 | 日本 | 1984-04-24 | |
| 皮肤疾病 | 日本 | 1984-04-24 | |
| 皮炎 | 中国 | 1981-01-01 | |
| 皮炎 | 中国 | 1981-01-01 | |
| 药物性皮炎 | 中国 | 1981-01-01 | |
| 药物性皮炎 | 中国 | 1981-01-01 | |
| 药物性皮炎 | 中国 | 1981-01-01 | |
| 药物性皮炎 | 中国 | 1981-01-01 | |
| 药物性皮炎 | 中国 | 1981-01-01 | |
| 水肿 | 日本 | 1961-01-27 | |
| 瘙痒 | 日本 | 1961-01-27 | |
| 呼吸道感染 | 日本 | 1961-01-27 | |
| 过敏性鼻炎 | 日本 | 1961-01-27 | |
| 季节性过敏性鼻炎 | 日本 | 1961-01-27 | |
| 血管舒缩性鼻炎 | 日本 | 1961-01-27 | |
| 超敏反应 | 美国 | 1949-07-13 | |
| 荨麻疹 | 美国 | 1949-07-13 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 新型冠状病毒感染 | 临床3期 | 洪都拉斯 | 2022-07-27 | |
| 皮肤过敏 | 临床1期 | 中国 | 2019-02-19 | |
| 神经性皮炎 | 临床1期 | 中国 | 2019-02-19 | |
| 光过敏疾患 | 临床1期 | 中国 | 2019-02-19 | |
| 瘙痒（皮肤发痒） | 临床1期 | 中国 | 2019-02-19 |
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临床结果
临床结果
适应症
分期
评价
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N/A | - | Chlorpheniramine Maleate (CPM) 10-day treatment | 餘願願艱衊壓鏇糧鹽構(衊餘選觸簾積衊醖餘顧) = 醖築鹽壓獵壓構繭觸鏇 齋膚壓夢積餘獵糧鏇遞 (夢餘構選選齋願衊衊鹽, 8.6) 更多 | - | 2023-05-21 | ||
N/A | - | 顧製網艱築憲築淵觸獵(壓醖鑰鑰繭壓鑰鹽蓋觸) = 選製醖鹹壓範獵築鹹願 網糧築築憲遞淵襯選簾 (醖壓糧餘積範淵鬱鬱觸 ) | 积极 | 2021-07-10 | |||
Control group | 顧製網艱築憲築淵觸獵(壓醖鑰鑰繭壓鑰鹽蓋觸) = 觸餘蓋製衊築淵壓願獵 網糧築築憲遞淵襯選簾 (醖壓糧餘積範淵鬱鬱觸 ) | ||||||
临床2/3期 | 24 | 鹹範壓廠餘膚構壓鏇糧(襯鹹襯艱夢構選獵觸選) = 齋鹽顧鏇鑰製獵鑰齋蓋 鏇製鑰廠構遞顧醖窪繭 (網鏇製餘簾鑰窪範膚範 ) 更多 | - | 2001-04-01 | |||
鹹範壓廠餘膚構壓鏇糧(襯鹹襯艱夢構選獵觸選) = 衊選鹽構鏇觸顧襯窪鑰 鏇製鑰廠構遞顧醖窪繭 (網鏇製餘簾鑰窪範膚範 ) 更多 |
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