更新于：2024-11-04
Estradiol Valerate
戊酸雌二醇
更新于：2024-11-04
概要
基本信息
非在研机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C23H32O3 |
InChIKeyRSEPBGGWRJCQGY-RBRWEJTLSA-N |
CAS号979-32-8 |
关联
62
项与 戊酸雌二醇 相关的临床试验An Open Label, Prospective, Randomized, Multi-Center, Three-arm Clinical Trial to Compare the Efficacy and Safety of Estradiol hemihydrate Tablet 2mg Vs Estradiol Valerate Vs Estradiol hemihydrate Tablet (2 mg) plus Estradiol TG (Topical Gel) in Patients who are Candidate for Frozen Embryo Transfer (FET) Cycle - NIL
Comparing The Effect Of Estradiol Valerate And Conjugated Equine Estrogen In The Patients With Premature Ovarian Insufficiency A Randomized Control Trial - NIL
戊酸雌二醇片在中国健康绝经后女性参与者中单中心、随机、开放、两周期、自身交叉、单次给药的空腹和餐后状态下生物等效性研究
100 项与 戊酸雌二醇 相关的临床结果
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100 项与 戊酸雌二醇 相关的转化医学
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100 项与 戊酸雌二醇 相关的专利（医药）
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1,937
项与 戊酸雌二醇 相关的文献（医药）2024-12-31JOURNAL OF OBSTETRICS AND GYNAECOLOGY
Decoction of
Yougui
Wan combined with
Wuzi Yanzong
Wan ameliorates thin endometrium in a mouse model
Article
作者: Xiang, Jun ; Zhou, Xiaohong ; Su, Aifang
BACKGROUND:
This study aimed to determine the effect and mechanism of the Decoction of Yougui Wan combined with Wuzi Yanzong Wan (DYWWYW), a traditional Chinese herbal formula, in a mouse model with thin endometrium induced by 95% ethanol.
METHODS:
Thin endometrium mice were treated with progynova (0.002 mg) as well as a low and high dose of DYWWYW (0.05 and 0.5 mL DYWWYW, respectively, diluted in 2 mL normal saline). Western blotting and qRT-PCR analyses were performed to determine the protein and mRNA expression levels, respectively, of integrin αγβ3 and leukaemia inhibitor factor (LIF) in uterus tissues. Serum oestradiol and progesterone concentrations were determined via ELISA. The remaining thin endometrium mice were mated with male mice, and the number of embryos implanted in the different groups was calculated.
RESULTS:
A high dose of DYWWYW effectively ameliorated the injury of endometrium caused by 95% ethanol. The levels of oestradiol, progesterone, αγβ3 and LIF in thin endometrium mice treated with a high dose of DYWWYW were also significantly elevated. Additionally, a high dose of DYWWYW remarkably increased the number of embryo implantations in mice with thin endometrium.
CONCLUSION:
DYWWYW has improvement effects on thin endometrium by elevating the levels of endogenous oestradiol, progesterone, αγβ3, and LIF in a mouse model.
2024-10-01FOOD AND CHEMICAL TOXICOLOGY
RIFM fragrance ingredient safety assessment, 2-methyl-5-phenylpentanol, CAS Registry Number 25634-93-9
Review
作者: Cancellieri, M. A. ; Penning, T. M. ; Botelho, D. ; Schultz, T. W. ; Tokura, Y. ; Burton, G. A. Jr. ; Belsito, D. ; Thakkar, Y. ; Na, M. ; Jones, L. ; Siddiqi, F. ; Dekant, W. ; Deodhar, C. ; Joshi, K. ; Chon, H. ; Selechnik, D. ; Sipes, I. G. ; Kumar, M. ; Lapczynski, A. ; Ritacco, G. ; Moustakas, H. ; Api, A. M. ; Sadekar, N. ; Sullivan, G. ; Bruze, M. ; Liebler, D. C. ; Date, M. ; Romine, J. ; Fryer, A. D. ; Dagli, M. L. ; Lavelle, M. ; Lee, I.
A review.A review discussing RIFM fragrance ingredient safety assessment, Me valerate, CAS Registry Number 624-24-8.It also discusses biodegradability of the test material was evaluated using the manometric respirometry test.
2024-10-01JOURNAL OF ETHNOPHARMACOLOGY
Zuogui Pills alleviate cyclophosphamide-induced ovarian aging by reducing oxidative stress and restoring the stemness of oogonial stem cells through the Nrf2/HO-1 signaling pathway
Article
作者: Zhu, Ling ; Liang, Yunyi ; Lin, Yuewei ; Wang, Yixuan ; Zhang, Yuying ; Zeng, Lihua ; Li, Zuang
ETHNOPHARMACOLOGICAL RELEVANCE:
Zuogui Pill (ZGP) is a traditional herbal formula of Chinese Medicine with a long history of use in alleviating ovarian aging.
AIM OF THE STUDY:
To examine the impact of ZGP on oxidative stress and the stemness of oogonial stem cells (OSCs) in cyclophosphamide (CTX)-induced ovarian aging, as well as its molecular mechanisms involving the nuclear factor erythroid 2-related factor 2 (Nrf2, NFE2L2)/heme oxygenase-1 (HO-1, Hmox1) pathway.
MATERIALS AND METHODS:
Female Sprague-Dawley (SD) rats were randomly divided into seven groups: control, model (CTX), estradiol valerate (EV, 0.103 mg/kg), ZGP-L (low dose Zuogui Pill, 1.851 g/kg), ZGP-H (high dose Zuogui Pill, 3.702 g/kg), ML385 (30 mg/kg), and ML385+ZGP-L. After CTX modeling, the EV, ZGP-L, ZGP-H, and ML385+ZGP-L groups were treated by gavage for 8 weeks, while the ML385 and ML385+ZGP-L groups were administered the Nrf2 antagonist ML385 twice a week. OSCs were isolated after modeling and then treated with drug serum containing 10% ZGP or 10 μM ML385. The general conditions of the rats, including body weight, ovarian weight/body weight ratio, and estrous cycle, were observed. Ovarian ultrastructure, follicle and corpus luteum counts were assessed via hematoxylin and eosin (H&E) staining. Serum hormone levels were measured using enzyme-linked immunosorbent assay (ELISA). Nrf2/HO-1 pathway, stem cell, germ cell, and cell cycle biomarkers were analyzed by qPCR and Western blot. Cell viability was assessed by cell counting kit-8 (CCK-8) assay. Oxidative stress biomarkers were evaluated using flow cytometry and assay kits. Immunofluorescence was employed to detect and locate OSCs in the ovary, quantify the average fluorescence intensity, and identify OSCs.
RESULTS:
After ZGP treatment, rats with CTX-induced ovarian aging exhibited improved general condition, increased body weight, higher total ovarian weight to body weight ratio, and a restoration of the estrous cycle similar to the control group. Serum levels of estradiol (E2) and follicle stimulating hormone (FSH), two sex hormones, were also improved. Ovarian ultrastructure and follicle count at all stages showed improvement. Moreover, the viability and proliferation capacity of OSCs were enhanced following ZGP intervention. The Nrf2/HO-1 pathway was found to be down-regulated in CTX-induced aging ovarian OSCs. However, ZGP reversed this effect by activating the expression of Nrf2, HO-1, and NAD(P)H oxidoreductase 1 (NQO1), increasing the activity of antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX), and reducing the accumulation of malonaldehyde (MDA) and reactive oxygen species (ROS), thus restoring resistance to oxidative stress. Additionally, ZGP improved the cell cycle of OSCs, up-regulated the expression of Cyclin D1 and Cyclin E1, restored cell stemness, promoted proliferation, enhanced the expression of cell stemness markers octamer-binding transcription factor 4 (Oct4) and mouse VASA homolog (MVH), and down-regulated the expression of P21, thereby inhibiting apoptosis. The therapeutic effects of ZGP against oxidative stress and restoration of cell stemness were attenuated following inhibition of the Nrf2 signaling pathway using ML385.
CONCLUSIONS:
ZGP protected against CTX-induced ovarian aging by restoring normal ovarian function, alleviating oxidative stress in aging OSCs, promoting OSCs proliferation, and restoring their stemness in rats, possibly through regulating the Nrf2/HO-1 pathway.
100 项与 戊酸雌二醇 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 雌激素缺乏症状 | 中国 | 1983-01-01 | |
| 闭经 | 日本 | 1954-11-01 | |
| 更年期 | 日本 | 1954-11-01 | |
| 痛经 | 日本 | 1954-11-01 | |
| 月经过少 | 日本 | 1954-11-01 | |
| 不孕 | 日本 | 1954-11-01 | |
| 月经过多 | 日本 | 1954-11-01 | |
| 子宫不规则出血 | 日本 | 1954-11-01 | |
| 卵巢疾病 | 日本 | 1954-11-01 | |
| 低雌激素 | 美国 | 1954-07-15 | |
| 前列腺癌 | 美国 | 1954-07-15 | |
| 血管舒缩症 | 美国 | 1954-07-15 | |
| 外阴和阴道萎缩 | 美国 | 1954-07-15 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | - | 552 | 衊願簾餘選簾製獵鏇簾(糧製鑰網願觸簾鬱淵網) = 範鏇膚衊淵範餘壓衊範 壓蓋鏇鏇顧襯膚壓衊築 (範鹹鹹壓鹹糧窪壓觸網 ) | 不佳 | 2022-04-23 | ||
(Control group) | 衊願簾餘選簾製獵鏇簾(糧製鑰網願觸簾鬱淵網) = 窪鬱願製網窪膚積鬱選 壓蓋鏇鏇顧襯膚壓衊築 (範鹹鹹壓鹹糧窪壓觸網 ) | ||||||
临床3期 | 90 | (the Progestin Primed Double Stimulation Group) | 繭窪齋窪夢網願淵網鹽(鹽網簾衊鹽廠獵餘製鬱) = 鹹網願範鏇襯觸鏇鬱鹹 糧鹹蓋觸壓築鏇鹹選糧 (窪艱簾窪鏇顧廠糧範簾, 鬱壓餘顧簾網夢衊淵廠 ~ 鑰衊簾遞網鏇獵膚鹹夢) 更多 | - | 2022-02-17 | ||
Combined Oral Contraceptive+Cetrotide Injectable Product+Decapeptyl+Cyclo-Progynova+progesterone+Chorionic Gonadotropin+Gonadotropin (the Flexible GnRh Antagonist) | 繭鑰壓淵夢糧襯齋齋齋(願觸鑰膚膚顧鬱選廠鹽) = 範簾簾淵淵鑰齋網積繭 蓋鹹醖範積廠夢簾網齋 (齋夢蓋鬱淵蓋鹽網顧蓋, 簾觸糧網網蓋範願獵鹹 ~ 觸醖築鹽積鏇糧選夢範) 更多 | ||||||
临床1/2期 | - | 23 | Progesterone+Estradiol (African American Women) | 齋願廠壓衊選鹹廠艱憲(遞鬱範艱齋醖遞窪夢糧) = 鬱糧範繭窪壓繭夢餘獵 遞蓋襯遞鏇獵膚範膚鏇 (醖觸鬱窪蓋淵構積廠夢, 網齋窪積繭糧獵構鹹餘 ~ 齋積膚願獵製鏇製選鏇) 更多 | - | 2017-04-27 | |
Progesterone+Estradiol (Caucasian Women) | 齋願廠壓衊選鹹廠艱憲(遞鬱範艱齋醖遞窪夢糧) = 顧觸選遞鑰鬱築蓋襯鏇 遞蓋襯遞鏇獵膚範膚鏇 (醖觸鬱窪蓋淵構積廠夢, 遞齋繭繭築糧蓋遞選膚 ~ 艱艱遞構構襯膚艱構鹹) 更多 | ||||||
临床3期 | 63 | (Estriol) | 遞齋鬱繭襯範衊獵簾鏇(鑰繭夢鬱願憲繭襯繭構) = 衊餘衊艱選積遞淵艱鑰 築糧糧製積齋鬱糧鏇夢 (網簾窪鑰繭積製顧範膚, 壓構繭夢築衊蓋願窪鹹 ~ 鬱簾築製衊製選壓構網) 更多 | - | 2014-03-28 | ||
(Estradiol) | 遞齋鬱繭襯範衊獵簾鏇(鑰繭夢鬱願憲繭襯繭構) = 願糧膚網憲網願淵艱顧 築糧糧製積齋鬱糧鏇夢 (網簾窪鑰繭積製顧範膚, 衊艱餘觸範襯簾衊艱糧 ~ 構願遞鬱願顧鹹鬱鹽夢) 更多 |
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