A Phase II Study to Evaluate the Safety and Efficacy of Rigosertib (ON 01910) Plus Pembrolizumab in Patients With Metastatic Melanoma Refractory to Immune Checkpoint Blockade

This phase II clinical trial tests how well rigosertib plus pembrolizumab workings in treating patients with melanoma which cannot be removed by surgery (unresectable) or that has spread from where it first started (primary site) to other places in the body (metastatic), and that has not responded to previous treatment with PD-1 or PD-L1 inhibitors (refractory). Rigosertib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and may change the immune system to make immunotherapy more effective. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving rigosertib in combination with pembrolizumab may be more effective in treating patients with unresectable metastatic melanoma that has not responded to previous treatment with PD-1 or PD-L1 inhibitors than giving either drug alone.

开始日期2023-05-09

申办/合作机构

The Vanderbilt-Ingram Cancer Center

NCT04177498

/ Completed早期临床1期IIT

A Pilot, Open Study to Assess Efficacy and Safety of Rigosertib in Patients With Recessive Dystrophic Epidermolysis Bullosa Associated Locally Advanced/Metastatic Squamous Cell Carcinoma

This pilot trial studies how rigsertib sodium works in treating patients with Recessive Dystrophic Epidermolysis bullosa (RDEB) with locally advanced Squamous Cell Carcinoma (SCC). Rigosertib may selectively target Epidermolysis bullosa (EB) cancer cells while leaving normal EB cells unaffected.

开始日期2021-08-24

申办/合作机构

Thomas Jefferson University

[+1]

NCT03786237

/ Completed临床1/2期IIT

A Phase II, Open Study to Assess Efficacy and Safety of Rigosertib in Patients With Recessive Dystrophic Epidermolysis Bullosa Associated Locally Advanced/Metastatic Squamous Cell Carcinoma

Epidermolysis bullosa (EB) is a heritable skin disease characterized by marked fragility of epithelialized tissue with blistering in skin and mucous membranes following the slightest mechanical trauma. Eighty percent of all patients suffering from recessive dystrophic EB (RDEB), a subtype originating from mutations in the COL7A1 gene, develop squamous cell carcinoma (SCC). In RDEB patients SCC presents early (most patients are in their 20s or 30s) and shows a highly aggressive metastatic course which often leads to premature death at this young age.
In light of scarce data on the efficacy and safety of systemic treatment regimens for advanced SCC, the investigators propose to perform a small, "first in EB " trial of an experimental drug called rigosertib for the treatment of EB cancer. The trial will be conducted in two study centres, in London and Salzburg, and will last approximately 2.5 years with each patient recruited being in the study for 1 year. The drug is a polo-like kinase inhibitor interfering with different molecular pathways that are essential for cancer cell growth. Rigosertib was developed by Onconova Therapeutics and is currently tested in several clinical trials for a number of other cancers including myelodysplastic syndrome (a cancer of the blood). The investigators have identified that rigosertib most selectively kills EB cancer cells in vitro while leaving normal EB skin cells unaffected. This project will evaluate whether rigosertib is capable of inducing an anti-cancer response in EB patients and whether the drug is well-tolerated. Mechanisms of molecular targeting of squamous cancer cells by rigosertib will further be investigated in EB patients, also aiming at the identification of biomarkers that may allow the predictive identification of best responders.

开始日期2021-04-12

申办/合作机构

Gemeinnützige Salzburger Landeskliniken Betriebsgesellschaft

100 项与瑞格色替相关的临床结果

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100 项与瑞格色替相关的转化医学

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100 项与瑞格色替相关的专利（医药）

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155

项与瑞格色替相关的文献（医药）

2026-10-06·CIRCULATION

Rigosertib Reverses Hypertrophic Cardiomyopathy in Noonan Syndrome

Article

作者: Gao, Sophie ; Marchetti, Katya ; Ng, Simon ; Rodriguez, Nelson A ; Kontaridis, Maria I ; Aleman, Angelika G ; Kurzum, Sereene ; Bohler, Damian ; Legler, Levi ; Gelb, Bruce D ; Wang, Angela ; Das, Tirtha ; Xu, Bing ; Cagan, Ross L ; Lin, Hung-Mo ; Kessinger, Chase W ; Ocorr, Karen ; Sun, Yan ; Vredenburg, Izabella ; Dinenno, Frank A ; Suarez-Farinas, Mayte ; Keshavarz Shirazi, Tara

BACKGROUND::

RASopathies constitute a group of rare genetic disorders caused by mutations in genes along the canonical RAS/mitogen-activated protein kinase (MAPK) signaling pathway, affecting cell growth and differentiation. These syndromes, which include Noonan syndrome (NS), are characterized by developmental delays, distinctive facial dysmorphia, and cardiac defects, notably hypertrophic cardiomyopathy (HCM). Despite their prevalence and impact, therapeutic options for RASopathies remain limited. Rigosertib, a novel dual RAS/MAPK and phosphatidylinositol 3-kinase (PI3K)/AKT pathway inhibitor, is currently in clinical trials for treatment of melanoma and recessive dystrophic epidermolysis bullosa. Here, we identify rigosertib as a candidate therapy for RAF1-associated HCM.

METHODS::

We performed a drug screen of clinically relevant compounds in transgenic Drosophila models of RASopathies to identify candidate therapeutics. Cardiac-targeted Drosophila models expressing RASopathy-associated transgenes were used to evaluate the effects of rigosertib on cardiac hypertrophy and compare its efficacy with the mitogen-activated protein kinase kinase (MEK) inhibitor trametinib. Therapeutic efficacy was further assessed in a mammalian model using Raf1L613V/+ knock-in mice treated with rigosertib for 6 weeks. Cardiac structure and function were evaluated by echocardiography, histology, and molecular analyses, including assessment of cardiomyocyte size, fetal gene expression, and extracellular signal-regulated kinase/AKT signaling. Additional NS-associated phenotypes, including skeletal growth and craniofacial abnormalities, were also evaluated.

RESULTS::

Rigosertib was effective across a panel of transgenic Drosophila RASopathy models, suggesting activity against multiple disease variants. In cardiac-targeted fly models, rigosertib reduced cardiac hypertrophy and outperformed trametinib. In Raf1L613V/+ mice, 6 weeks of treatment significantly improved left ventricular chamber dimension, posterior wall thickness, heart mass, and cardiomyocyte size, resulting in reversal of cardiac hypertrophy. Rigosertib also normalized fetal gene expression and inhibited extracellular signal-regulated kinase and AKT signaling in primary cardiomyocytes. In addition to reversing cardiac pathology, rigosertib significantly improved other NS-associated features, including increased bone growth and correction of craniofacial abnormalities.

CONCLUSIONS::

Together, our findings suggest that rigosertib normalizes and reverses RASopathy-associated HCM and other NS-associated syndromic features, supporting its development as a promising treatment for RAF1-associated HCM and, potentially, other RASopathy-dependent pathologies. This study not only highlights the therapeutic potential of rigosertib but also demonstrates the utility of an integrated approach using Drosophila and mammalian models to elucidate drug effects across complex biological systems.

2026-06-01·Food Science & Nutrition

Polyphenol‐Rich Duhuo Jisheng Decoction Enhances Mesenchymal Stem Cell–Derived Exosome–Mediated Chondroprotection via PI3K/AKT Signaling in Osteoarthritis

Article

作者: Liu, Jun ; Yu, Tian ; Wang, Weiran ; Xie, Hui ; Wang, Lixin ; Liao, Zhouwei ; Zhang, Shaoqun ; Jiang, Shunwan ; Yang, Junzheng ; Ni, Xinqiang

ABSTRACT:

Osteoarthritis (OA), a representative chronic degenerative joint disease, is closely associated with chronic inflammation and dysregulated cell survival. Dietary polyphenols are recognized for their protective roles against chronic inflammatory conditions. Duhuo Jisheng Decoction (DHJST), a polyphenol‐rich traditional herbal formula, is widely used for degenerative joint diseases. This study aims to explore the novel mechanisms of DHJST‐derived bioactives in enhancing the chondroprotective potential of mesenchymal stem cell‐derived exosomes. We integrated network pharmacology and machine learning to identify the core AKT‐related targets of DHJST. Bone marrow mesenchymal stem cells (BMSCs) were preconditioned with DHJST‐containing serum to generate enhanced exosomes (DHJST‐Exos), applying to IL‐1β–stimulated rat chondrocytes and a collagenase‐induced OA rat model. The therapeutic efficacy was evaluated via inflammatory markers, extracellular matrix (ECM) homeostasis, and apoptosis assays, with the PI3K/AKT inhibitor Rigosertib used for mechanistic validation. Network pharmacology identified key bioactive polyphenols including wogonin, quercetin, kaempferol, and other polyphenol‐like constituents in DHJST that significantly modulate the PI3K/AKT pathway. DHJST ‐Exos effectively suppressed TNF‐α and IL‐6, reduced MMP‐13 and ADAMTS‐5 levels, and restored COL2A1 and Aggrecan expression. Furthermore, DHJST ‐Exos attenuated chondrocyte apoptosis by regulating the Caspase‐3/Bax/Bcl‐2 axis. Mechanistically, DHJST ‐Exos up‐regulated the expression of hub genes JUN and KDR via AKT phosphorylation, a protective effect that was significantly abrogated by Rigosertib. This study demonstrates that polyphenol‐rich DHJST enhances the therapeutic efficacy of BMSC‐derived exosomes against OA by activating the AKT signaling pathway and its key nodes, JUN and KDR. This synergistic strategy, combining dietary bioactives with exosome‐mediated delivery, represents a promising adjunctive approach for the management of chronic degenerative joint diseases.

2026-05-01·CANCER LETTERS

GPI inactivation mediates pentose phosphate pathway flux switch-on inducing temozolomide resistance in glioma stem cell

Article

作者: You, Yongping ; Liu, Xingdong ; Ge, Xin ; Yin, Jianxing ; Wang, Xiefeng ; Du, Zelei ; Chen, Yunxiang ; Lu, Chenfei ; Zhang, Junxia ; Yan, Wei

Temozolomide (TMZ) resistance in glioblastoma (GBM) remains a substantial clinical challenge. Targeting glioma stem cells (GSCs) represents a promising strategy to overcome chemoresistance and tumor recurrence. In this study, we found that GSCs maintain chemoresistance by increasing pentose phosphate pathway (PPP) flux compared with differentiated tumor cells. Following TMZ treatment, the activity of glucose-6-phosphate isomerase (GPI), a key glycolytic enzyme that catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, was significantly suppressed in GSCs. Mechanistically, Ataxia Telangiectasia Mutated (ATM), activated by TMZ-induced DNA damage, phosphorylates polo-like kinase 1 (PLK1), promoting its nuclear export. PLK1 subsequently phosphorylates GPI at T215, leading to suppression of GPI activity. Targeting the ATM/PLK1/GPI axis through combinational treatment with rigosertib may therefore represent a therapeutic strategy. Moreover, PLK1 expression and GPI pT215 levels may serve as potential candidate markers for GBM. Collectively, activation of the ATM/PLK1/GPI axis plays a critical role in regulating PPP flux and TMZ resistance in GSCs.

项与瑞格色替相关的新闻（医药）

2026-04-22

·动脉网

PureTech报告了LYT-200在复发/难治性（R/R）高危（HR）骨髓增生异常综合征（MDS）和R/R急性髓系白血病（AML）的1b期试验中取得积极的初步数据

PDF Version PDF 版本RNS Number : 4332B RNS编号：4332B PureTech Health PLC 纯技术健康公司22 April 2026 2026年4月22日 22 April 2026 2026年4月22日PureTech Health plc PureTech Health plcPureTech Reports Positive Topline Data from Phase 1b Trial of LYT-200 in Relapsed/Refractory (R/R) High-Risk (HR) Myelodysplastic Syndrome (MDS) and R/R Acute Myeloid Leukemia (AML) PureTech报告了LYT-200在复发/难治性（R/R）高危（HR）骨髓增生异常综合征（MDS）和R/R急性髓系白血病（AML）的1b期试验中取得积极的初步数据。Phase 1b dataset with LYT-200 demonstrates complete responses and favorable tolerability across both R/R HR-MDS and R/R AML LYT-200的1b期数据集显示，在R/R HR-MDS和R/R AML中均获得了完全缓解且耐受性良好 PureTech's 纯技术的Founded Entity, Gallop Oncology, to advance LYT-200 first in R/R HR-MDS, with continued development planned in R/R AML 成立实体公司Gallop Oncology，以推进LYT-200在R/R HR-MDS中的首次应用，并计划继续在R/R AML中进行开发。Company plans to engage with the 公司计划参与其中U.S. Food and Drug Administration 美国食品药品监督管理局to discuss the design of a subsequent trial in R/R HR-MDS that has the potential to support registration 讨论在R/R HR-MDS中设计一个有可能支持注册的后续试验。PureTech Health plc 纯技术健康公司(Nasdaq: PRTC, LSE: PRTC) (' （纳斯达克：PRTC，伦敦证券交易所：PRTC）（'PureTech 纯科技' or the 'Company'), a hub-and-spoke biotherapeutics company dedicated to giving life to science and transforming innovation into value, today announced positive 或“公司”），一家致力于赋予科学生命并将创新转化为价值的轮辐式生物治疗公司，今天宣布了积极的topline data from the completed Phase 1b clinical trial of LYT-200, a first-in-class, fully human anti-galectin-9 monoclonal antibody, in heavily pretreated patients with relapsed/refractory (R/R) high-risk (HR) myelodysplastic syndrome (MDS) and R/R acute myeloid leukemia (AML). Based on the results, . LYT-200（一种首创的全人源抗半乳糖凝集素-9单克隆抗体）在经过多线治疗的复发/难治性（R/R）高危（HR）骨髓增生异常综合征（MDS）和R/R急性髓系白血病（AML）患者中已完成的1b期临床试验的顶线数据。基于这些结果，。PureTech's 纯技术的Founded Entity, 成立实体，Gallop Oncology, has selected a recommended Phase 2 dose (RP2D) and intends to engage with the Gallop Oncology 已选定推荐的 Phase 2 剂量 (RP2D)，并计划进行交流。U.S. Food and Drug Administration 美国食品药品监督管理局(FDA) to discuss the design of a subsequent trial that could potentially support registration of LYT-200 in R/R HR-MDS. 与FDA讨论可能支持LYT-200在R/R HR-MDS中注册的后续试验设计。'The data from the completed Phase 1b trial highlight the potential for LYT-200 to offer a differentiated treatment approach across a range of myeloid hematological malignancies,' said “1b期试验完成的数据突显了LYT-200在多种髓系血液恶性肿瘤中提供差异化治疗方案的潜力，”表示Aleksandra Filipovic 亚历山德拉·菲利波维奇, M.D., Ph.D., Head of Oncology at 医学博士，肿瘤科主任PureTech 纯技术and Chief Medical Officer of Gallop Oncology. 'Across patients with R/R HR-MDS and R/R AML, treatment with LYT-200 resulted in Gallop Oncology的首席医疗官。“在R/R HR-MDS和R/R AML患者中，使用LYT-200进行治疗导致了deep responses 深度响应with an exceptionally favorable safety profile. Importantly, the data in R/R HR-MDS were particularly compelling and support prioritizing this indication, especially given the significant unmet need and lack of successful innovation to help these patients. W 具有非常有利的安全性特征。重要的是，R/R HR-MDS的数据尤其令人信服，并支持优先考虑这一适应症，特别是鉴于显著的未满足需求和缺乏帮助这些患者的成功创新。e intend to engage with the FDA to discuss the design of a subsequent trial 我们打算与FDA接洽，讨论后续试验的设计。in R/R HR- 在R/R HR-中MDS, as our goal is to accelerate delivery of this promising first-in-class therapy to patients while also laying the foundation for broader clinical development, including in AML.' MDS，我们的目标是加快这种有前景的首创疗法向患者的交付，同时也为更广泛的临床开发奠定基础，包括在AML中的应用。The completed Phase 1b trial (NCT05829226), conducted across nine 已完成的 1b 期试验（NCT05829226），在九个地方进行U.S. 美国sites, evaluated LYT-200 both as a monotherapy and in combination regimens in two heavily pretreated patient populations. 在两个经过多次治疗的患者群体中，评估了LYT-200作为单一疗法和联合治疗方案的效果。The study included dose escalation of monotherapy LYT-200, followed by dose escalation of LYT-200 in combination with a hypomethylating agent (HMA; azacitidine or decitabine) in patients with R/R HR-MDS and with venetoclax (VEN) and an HMA in R/R AML. 该研究包括对单药LYT-200的剂量递增，随后在R/R HR-MDS患者中与低甲基化剂（HMA；阿扎胞苷或地西他滨）联合使用LYT-200的剂量递增，以及在R/R AML患者中与维奈托克（VEN）和HMA联合使用的剂量递增。'The safety profile, combinatorial potential, and level of clinical activity observed with LYT-200 in this Phase 1b study across both R/R HR-MDS and R/R AML is very encouraging, particularly given the number of prior lines of treatment and the risk profile in the populations studied,' “在这一 1b 期研究中，LYT-200 在 R/R HR-MDS 和 R/R AML 中展现的安全性、组合潜力和临床活性水平非常令人鼓舞，特别是考虑到先前治疗的次数以及所研究人群的风险特征。”said 说Amir T. Fathi 阿米尔·T·法蒂, M.D., Program Director of the 医学博士，项目主任Center for Leukemia 白血病中心at the 在Mass General Brigham Cancer Institute 马萨诸塞综合医院布里格姆癌症研究所and Professor of Medicine at 医学教授Harvard Medical School 哈佛医学院. 。'In R/R high-risk MDS, where treatment options are extremely limited and outcomes are poor, the findings are particularly notable. In this context, the potential to achieve clinical responses without added toxicity would represent a meaningful advance in the MDS treatment landscape and warrants continued clinical development.'. “在治疗选择非常有限且预后较差的复发/难治性高危MDS中，这些发现尤其显著。在此背景下，能够在不增加毒性的情况下实现临床反应，将代表MDS治疗领域的一项有意义的进步，并值得进一步的临床开发。”'The results from this Phase 1b trial provide a strong foundation for the next stage of development of LYT-200,' said “这项1b期试验的结果为LYT-200的下一阶段开发提供了坚实的基础，”Eric Elenko 埃里克·埃伦科, Ph.D., President and Co-founder of 博士，总裁兼联合创始人PureTech 纯技术and Acting Chief Executive Officer of Gallop Oncology. 'Our decision to prioritize relapsed/refractory high-risk MDS reflects a focused and disciplined approach, grounded in both the data generated to date and the potential to address a tremendous patient need. We intend to engage with the FDA to discuss a subsequent trial design with the potential to support registration, while continuing to evaluate the broader potential of LYT-200.'. Gallop Oncology的代理首席执行官表示：“我们决定优先考虑复发/难治性高危MDS，这反映了一种专注且有条理的方法，基于迄今为止生成的数据和满足巨大患者需求的潜力。我们打算与FDA沟通，讨论一个有可能支持注册的后续试验设计，同时继续评估LYT-200的更广泛潜力。”TOPLINE SAFETY DATA 顶线安全数据LYT-200 demonstrated a favorable and consistent safety profile across all cohorts and dose levels studied (N=101), with no dose-limiting toxicities, infusion-related reactions, LYT-200 dose reductions, or LYT-200-related serious adverse events (AEs), discontinuations, or deaths. Importantly, no overlapping or additive toxicities were observed when LYT-200 was combined with an HMA or VEN/HMA.. LYT-200在所有研究队列和剂量水平（N=101）中表现出良好且一致的安全性，未出现剂量限制性毒性、输注相关反应、LYT-200剂量减少、LYT-200相关的严重不良事件（AEs）、停药或死亡。重要的是，当LYT-200与HMA或VEN/HMA联合使用时，未观察到重叠或叠加的毒性。Six patients at one study site reported experiencing hematology/chemistry-related Grade 3 or 4 AEs attributed as possibly related or related to LYT-200 in the combination arm at the RP2D dose. The reported AEs consisted of decreased levels of platelets, white blood cells, and neutrophils that were below the lower limit of normal physiological levels. 在一项研究中，六个患者报告在RP2D剂量下，联合治疗组中出现了可能与LYT-200相关或相关的3级或4级血液学/化学相关的不良事件（AE）。报告的不良事件包括血小板、白细胞和中性粒细胞水平下降至低于正常生理水平的下限。The blood count deficits for some of the relevant patients were present at baseline prior to the administration of LYT-200 and are common occurrences in patients due to the underlying advanced MDS/AML, as well as in those receiving VEN/HMA treatment. No other sites reported Grade 3 or greater AEs related to LYT-200 treatment.. 一些相关患者在使用LYT-200之前就存在基线水平的血细胞计数不足，这在患有潜在晚期MDS/AML的患者中是常见现象，接受VEN/HMA治疗的患者中也是如此。其他研究地点均未报告与LYT-200治疗相关的3级或更高级别的不良事件。TOPLINE 头条EFFICACY DATA 疗效数据Treatment with LYT-200 in combination with an HMA in R/R HR-MDS patients and VEN/HMA in R/R AML patients demonstrated robust antileukemic activity, including complete responses, bridging to transplant, and durable clinical benefit. The data also provided important insights into the contribution of LYT-200 within combination regimens.. 在R/R HR-MDS患者中使用LYT-200联合HMA治疗，以及在R/R AML患者中使用VEN/HMA治疗，显示出强大的抗白血病活性，包括完全缓解、桥接至移植以及持久的临床获益。数据还提供了关于LYT-200在联合方案中的贡献的重要见解。R/R HR-MDS 复发/难治性高危骨髓增生异常综合征Across all efficacy-evaluable 在所有可评估疗效的[1] [1]patients (n=11), the recommended Phase 2 dose (LYT-200 12mg/kg in combination with an HMA) demonstrated: 患者（n=11），推荐的二期剂量（LYT-200 12mg/kg 与 HMA 联合使用）显示：· ·27.3% complete response rate 27.3%的完全缓解率· ·9.1% partial response rate 9.1%的部分缓解率· ·9.1% marrow complete response rate 9.1%的骨髓完全缓解率· ·45.5% overall response rate 45.5%的总体响应率· ·18% conversion to transplant rate 18% 的移植率转换Due to the number of patients alive at the time of study completion (>50%), the upper bound of overall survival could not be calculated; therefore, the median overall survival for this cohort of 6.4 months is not considered fully mature. 由于研究结束时存活的患者数量较多（超过50%），无法计算总生存期的上限；因此，该队列6.4个月的中位总生存期不被视为完全成熟。Efficacy-evaluable patients had a median of 3 prior lines of therapy (range: 1-5), and all (100%) had previously been treated with an HMA. Additionally, all patients had high-risk cytogenetics, which - coupled with prior exposure to treatment - suggests biologically aggressive, treatment-refractory disease with elevated risk of progression and poor clinical outcomes. 疗效可评估的患者既往治疗中位数为3线（范围：1-5），并且所有患者（100%）均曾接受过HMA治疗。此外，所有患者均具有高危细胞遗传学特征，这与既往治疗暴露相结合，表明其疾病在生物学上具有侵袭性、对治疗耐药，并伴有较高的进展风险和不良临床结局。Taken together, these attributes underscore the potential mutation-agnostic mechanism of LYT-200 and its potential for broad clinical use.. 综合来看，这些属性突显了LYT-200潜在的与突变无关的作用机制及其广泛的临床应用潜力。R/R AML 复发/难治性急性髓系白血病Across all efficacy 横跨所有功效-e -evaluable 有价值的1 1patients (n=26), LYT-200 12mg/kg in combination with VEN/HMA demonstrated: 患者（n=26），LYT-200 12mg/kg 与 VEN/HMA 联用显示：· ·30.8% composite complete response rate 30.8%的复合完全缓解率[2] [2]; responders included patients with mutations associated with VEN resistance ；应答者包括与VEN耐药性相关的突变患者· ·7.7% partial response rate 7.7%的部分缓解率· ·42.3% overall response rate 42.3%的总体响应率 · ·19.2% conversion to transplant rate 19.2% 的移植转换率Due to the number of patients alive at the time of study completion (50%), the upper bound of overall survival could not be calculated; therefore, the median overall survival for this cohort of 8.2 months is not considered fully mature. 由于研究结束时存活的患者数量（50%），无法计算总生存期的上限；因此，该队列的中位总生存期为8.2个月，不被视为完全成熟。Efficacy-evaluable patients had a median of 2 prior lines of therapy (range: 1-9), and 84.6% had previously been treated with VEN/HMA. 疗效可评估的患者之前接受过中位数为2线的治疗（范围：1-9），且84.6%的患者曾接受过VEN/HMA治疗。INITIAL PHARMACODYNAMIC FINDINGS 初始药效学发现The systemic effects of LYT-200 were evaluated through pharmacodynamic analyses of peripheral blood mononuclear cells, a population of immune cells in the bloodstream that provides insight into how a treatment affects both the immune system and leukemic blast cells. These analyses suggest that LYT-200 engages complementary and potentially synergistic pathways directed at cancer cell killing and anti-cancer immune responses when combined with VEN and HMA-based therapy, which may contribute to the clinical activity observed in patients with relapsed/refractory disease following HMA and VEN/HMA treatment, in MDS and AML, respectively.. 通过对外周血单核细胞（一种血液中的免疫细胞群）进行药效学分析，评估了LYT-200的系统性效应，这些细胞可提供治疗对免疫系统和白血病母细胞影响的见解。这些分析表明，当LYT-200与VEN和基于HMA的疗法联合使用时，能够激活互补且潜在协同作用的通路，从而实现癌细胞杀伤和抗癌免疫反应，这可能有助于在MDS和AML中分别观察到的、经过HMA以及VEN/HMA治疗后复发/难治性疾病患者的临床活性。About Myelodysplastic Syndromes 关于骨髓增生异常综合征Myelodysplastic syndromes (MDS) are a group of serious blood cancers characterized by ineffective blood cell production in the bone marrow, leading to anemia, infections, and bleeding complications. 骨髓增生异常综合征 (MDS) 是一组严重的血液癌症，其特征是骨髓中血细胞生成无效，导致贫血、感染和出血并发症。[3] [3], ，[4] [4]MDS affects approximately 60,000-170,000 people in MDS影响了大约60,000-170,000人the United States 美国, with an estimated 30-40% of patients diagnosed with the more aggressive form of the disease known as high-risk (HR) MDS. ，约有30%-40%的患者被诊断为更具侵袭性的高风险（HR）MDS疾病形式。3, 3,[5] [5]HR-MDS is associated with poor outcomes, with median survival typically less than two years following diagnosis, and approximately 30% of patients progressing to acute myeloid leukemia (AML). 高危骨髓增生异常综合征（HR-MDS）预后较差，诊断后的中位生存期通常不到两年，且约30%的患者会进展为急性髓系白血病（AML）。4 4- -[6] [6]The current standard frontline treatment for HR-MDS are hypomethylating agents (HMAs), such as azacitidine and decitabine; however, most patients do not respond to these therapies or eventually stop benefiting from them. 高风险骨髓增生异常综合征 (HR-MDS) 的当前标准一线治疗方法是使用低甲基化药物 (HMAs)，例如阿扎胞苷和地西他滨；然而，大多数患者对这些疗法没有反应或最终停止从中受益。[7] [7]Once the disease becomes relapsed or refractory (R/R), outcomes are especially poor, with survival often limited to only a few months. 一旦疾病变得复发或难治性（R/R），结果尤其糟糕，生存期往往仅限于几个月。7 7, ，[8] [8]Treatment options for patients with R/R HR-MDS remain very limited. Only one therapy has been approved specifically for this setting in the past two decades, and it targets only a small subset of patients (~3-5%) with a specific genetic mutation. 复发/难治性高危骨髓增生异常综合征（R/R HR-MDS）患者的治疗选择仍然非常有限。在过去的二十年中，仅有一种疗法被专门批准用于此情况，且其仅针对一小部分（约3-5%）具有特定基因突变的患者。7 7As a result, there remains a significant need for new treatment approaches for patients with HR-MDS. 因此，对于高风险MDS患者，仍然存在对新治疗方法的重大需求。About Acute Myeloid Leukemia 关于急性髓系白血病Acute myeloid leukemia (AML) is an aggressive blood cancer characterized by the rapid growth of abnormal myeloid blast cells in the bone marrow and blood. It is the most common form of acute leukemia in adults, with a five-year survival rate of less than 30%. 急性髓系白血病（AML）是一种侵袭性的血液癌症，其特征是骨髓和血液中异常的髓系母细胞迅速增长。它是成人中最常见的急性白血病类型，五年生存率低于30%。[9] [9]Despite available therapies, many patients relapse or fail to respond, and outcomes are especially poor in the relapsed/refractory setting. Around 450,000 people globally are living with AML. 尽管有可用的治疗方法，许多患者仍会复发或未能响应，尤其是在复发/难治性情况下，结果尤其不佳。全球约有45万人患有急性髓系白血病（AML）。9 9AML is an area of urgent medical need where new therapies with improved safety, efficacy, and durability or responses are critical. Importantly, the incidence of AML is increasing, and the market is expected to grow to AML是一个迫切需要医疗的领域，新的疗法在安全性、有效性和持久性或反应方面都有显著改善。重要的是，AML的发病率正在增加，预计市场将会增长。$6 billion 60亿美元annually by 2030, 到2030年，每年[10] [10]underscoring the scale of the opportunity to bring forward therapies that are not only more effective but also applicable across a broader segment of patients. 强调了推出不仅更有效而且适用于更广泛患者群体的疗法的机会规模。 About LYT-200 关于LYT-200LYT-200 is a fully human IgG4 monoclonal antibody in development for the treatment of hematological malignancies. LYT-200 targets galectin-9, which is an important oncogenic driver and potent immunosuppressor in cancer, positioning it as a novel target for cancer therapy. LYT-200是一种处于开发阶段的全人源IgG4单克隆抗体，用于治疗血液系统恶性肿瘤。LYT-200靶向半乳糖凝集素-9（galectin-9），这是一种重要的致癌驱动因子和强大的免疫抑制剂，在癌症中具有关键作用，因此成为癌症治疗的一个新靶点。[11] [11]LYT-200 has been granted LYT-200 已被授予Fast Track 快速通道and 和Orphan Drug 孤儿药designations from the 来自的名称U.S. Food and Drug Administration 美国食品药品监督管理局(FDA) for the treatment of acute myeloid leukemia. 美国食品药品监督管理局（FDA）批准用于治疗急性髓系白血病。About Gallop Oncology 关于Gallop肿瘤学Gallop Oncology was founded by and is currently wholly-owned by Gallop Oncology 由其创立并且目前全资拥有。PureTech Health 纯技术健康plc (Nasdaq: PRTC, LSE: PRTC). Gallop is a clinical-stage biopharmaceutical company committed to transforming treatment paradigms for hematologic malignancies. Guided by science and driven to deliver meaningful outcomes for patients, Gallop is advancing a novel approach where efficacy, safety, and durability converge. plc（纳斯达克：PRTC，伦敦证券交易所：PRTC）。Gallop是一家处于临床阶段的生物制药公司，致力于改变血液恶性肿瘤的治疗模式。在科学的指导下，并以实现对患者有意义的结果为动力，Gallop正在推进一种新的方法，这种方法在疗效、安全性和持久性上达到了融合。Its lead candidate, LYT-200, is the most advanced candidate targeting galectin-9, an important oncogenic driver and potent immunosuppressor in cancer, offering a differentiated strategy to address some of the most challenging cancers. For more information, please visit . 其主要候选药物LYT-200是针对galectin-9的最先进的候选药物，galectin-9是癌症中重要的致癌驱动因子和强效免疫抑制剂，提供了一种差异化策略来应对一些最具挑战性的癌症。欲了解更多信息，请访问。www.galloponcology.com www.galloponcology.com. 。About PureTech Health 关于PureTech HealthPureTech Health 纯技术健康is a hub-and-spoke biotherapeutics company dedicated to giving life to science and transforming innovation into value. We do this through a proven, capital-efficient R&D model focused on opportunities with validated pharmacology and untapped potential to address significant patient needs. This strategy has produced dozens of therapeutic candidates, including three that have received . 是一家以枢纽和辐条模式运营的生物治疗公司，致力于赋予科学生命，并将创新转化为价值。我们通过一种经过验证的、资本高效的研发模式来实现这一目标，专注于那些具有已验证药理学和未开发潜力的机会，以满足重大的患者需求。这一战略已经产生了数十种治疗候选药物，其中三种已获得批准。U.S. 美国FDA approval. By identifying, shaping, and de-risking these high-conviction assets, and scaling them through dedicated structures backed by external capital, we accelerate their path to patients while creating sustainable value for shareholders. FDA批准。通过识别、塑造和降低这些高信念资产的风险，并通过外部资本支持的专用结构进行扩展，我们加速了它们对患者的路径，同时为股东创造了可持续的价值。For more information, visit 欲了解更多信息，请访问www.puretechhealth.com www.puretechhealth.comor connect with us on X (formerly Twitter) @puretechh. 或通过X（前身为Twitter）@puretechh与我们联系。Cautionary Note Regarding Forward-Looking Statements 关于前瞻性陈述的警告性说明This press release contains statements that are or may be forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements contained in this press release that do not relate to matters of historical fact should be considered forward-looking statements, including without limitation those related to the LYT-200 development program and development plans, its potential benefits to patients, plans for discussions with regulatory authorities, the further development of the program, future presentation of additional data from the program and our future prospects, developments and strategies. 本新闻稿包含根据1995年《私人证券诉讼改革法》定义的前瞻性陈述或可能为前瞻性陈述的所有内容。本新闻稿中所有与历史事实无关的声明均应被视为前瞻性陈述，包括但不限于与LYT-200开发计划及开发规划、其对患者的潜在益处、与监管机构的沟通计划、该计划的进一步开发、未来发布的更多数据以及我们的未来前景、发展和策略相关的声明。The forward-looking statements are based on current expectations and are subject to known and unknown risks, uncertainties and other important factors that could cause actual results, performance and achievements to differ materially from current expectations, including, but not limited to, those risks, uncertainties and other important factors described under the caption 'Risk Factors' in our Annual Report on Form 20-F for the year ended December 31, 2024, filed with the . 前瞻性声明基于当前预期，但受已知和未知风险、不确定性以及其他可能导致实际结果、表现或成就与当前预期存在重大差异的重要因素的影响，包括但不限于我们截至2024年12月31日的年度Form 20-F报告中“风险因素”标题下描述的风险、不确定性及其他重要因素，该报告已提交给。SEC 证券交易委员会and in our other regulatory filings. These forward-looking statements are based on assumptions regarding the present and future business strategies of the Company and the environment in which it will operate in the future. Each forward-looking statement speaks only as at the date of this press release. 并包含在我们的其他监管文件中。这些前瞻性陈述是基于公司当前和未来业务战略的假设以及公司未来运营环境的假设。每个前瞻性陈述仅代表本新闻稿发布之日的情况。Except as required by law and regulatory requirements, we disclaim any obligation to update or revise these forward-looking statements, whether as a result of new information, future events or otherwise.. 除非法律和监管要求另有规定，我们不承担更新或修改这些前瞻性陈述的义务，无论是由于新信息、未来事件或其他原因。PureTech 纯科技Public Relations 公共关系publicrelations@puretechhealth.com 公共关系@纯科技健康.comInvestor Relations 投资者关系IR@puretechhealth.com IR@puretechhealth.comUK 英国/EU Media 欧盟媒体Ben Atwell 本·阿特韦尔, ，Rob Winder 罗布·温德+44 (0) 20 3727 1000 +44 (0) 20 3727 1000puretech@fticonsulting.com 纯技术@fticonsulting.comUS Media 美国媒体Justin Chen 陈贾斯汀jchen@tenbridgecommunications.com jchen@tenbridgecommunications.com[1] [1]Efficacy evaluable is defined in the protocol as all patients who received a minimum one full cycle of LYT-200 (four doses) and had a minimum of one post-baseline disease assessment. The intent-to-treat population for the R/R HR-MDS cohort was n=12 and for the R/R AML cohort was n=33. 方案中将可评估疗效定义为所有接受至少一个完整周期LYT-200（四剂）治疗并且有至少一次基线后疾病评估的患者。R/R HR-MDS队列的意向治疗人群为n=12，R/R AML队列为n=33。[2] [2]Complete response + 完全响应 +complete response with incomplete hematological recovery 完全缓解伴不完全血液学恢复[3] [3]American Cancer Society 美国癌症协会. (2023). 。（2023）。What Is Myelodysplastic Syndrome? 什么是骨髓增生异常综合征？Retrieved from 检索自https://www.cancer.org https://www.cancer.org[4] [4]National Comprehensive Cancer Network. (2024). 国家综合癌症网络。（2024）NCCN Clinical Practice Guidelines in Oncology: Myelodysplastic Syndromes (Version 2.2024). NCCN临床实践指南：肿瘤学：骨髓增生异常综合征（2024年第2版）。Retrieved from 检索自https://www.nccn.org https://www.nccn.org[5] [5]Greenberg, P. L., Tuechler, H., Schanz, J., Sanz, G., Garcia-Manero, G., Solé, F., Bennett, 格林伯格，P. L.，图赫勒，H.，尚茨，J.，桑兹，G.，加西亚-马内罗，G.，索莱，F.，贝内特，J. M J. M., Bowen, D., Fenaux, P., Dreyfus, F., Kantarjian, H., Kuendgen, A., Levis, A., Malcovati, L., Cazzola, M., & Haase, D. (2012). Revised International Prognostic Scoring System for myelodysplastic syndromes. ., Bowen, D., Fenaux, P., Dreyfus, F., Kantarjian, H., Kuendgen, A., Levis, A., Malcovati, L., Cazzola, M., & Haase, D. (2012). 骨髓增生异常综合征的修订国际预后评分系统。Blood, 120 血液，120(12), 2454-2465. (12), 2454-2465。https://doi.org/10.1182/blood-2012-03-420489 https://doi.org/10.1182/blood-2012-03-420489[6] [6]Ma, X. (2012). Epidemiology of myelodysplastic syndromes. 马，X.（2012）。骨髓增生异常综合征的流行病学。The American Journal of Medicine 美国医学杂志, 125 ，125(7 Suppl), S2-S5. (7增刊), S2-S5。https://doi.org/10.1016/j.amjmed.2012.04.014 https://doi.org/10.1016/j.amjmed.2012.04.014[7] [7]Garcia-Manero, G., Fenaux, P., Al-Kali, A., Baer, 加西亚-马内罗，G.，费纳克斯，P.，阿尔-卡利，A.，贝尔， M. R M. R., Sekeres, M. A., Roboz, ., Sekeres, M. A., Roboz,G. J G. J., et al. (2016). Rigosertib versus best supportive care for patients with high-risk myelodysplastic syndromes after failure of hypomethylating drugs (ONTIME): A randomised, controlled, phase 3 trial. ., 等 (2016). Rigosertib 对比最佳支持治疗用于高危骨髓增生异常综合征患者在低甲基化药物失败后的疗效（ONTIME）：一项随机、对照、3期试验。Lancet Oncology, 17 柳叶刀肿瘤学，17 (4), 496-508. (4), 496-508。https://doi.org/10.1016/S1470-2045(16)00009-7 https://doi.org/10.1016/S1470-2045(16)00009-7[8] [8]Prébet, T., 普雷贝，T.，Gore, S 戈尔，S. D., Esterni, B., Gardin, C., Itzykson, R., Thepot, S., Quesnel, B., Dreyfus, F., Beyne-Rauzy, O., Vey, N., Recher, C., Adès, L., Fenaux, P., & Groupe Francophone des Myélodysplasies. (2011). Outcome of patients with higher-risk myelodysplastic syndromes after azacitidine treatment failure. D., Esterni, B., Gardin, C., Itzykson, R., Thepot, S., Quesnel, B., Dreyfus, F., Beyne-Rauzy, O., Vey, N., Recher, C., Adès, L., Fenaux, P., & 法语骨髓增生异常综合症小组（Groupe Francophone des Myélodysplasies）。(2011)。阿扎胞苷治疗失败后高危骨髓增生异常综合症患者的预后。Journal of Clinical Oncology 临床肿瘤学杂志, 29 ，29(24), 3322-3327. (24), 3322-3327。https://doi.org/10.1200/JCO.2011.35.8135 https://doi.org/10.1200/JCO.2011.35.8135[9] [9]Acute Myeloid Leukemia - Cancer Stat Facts. (n.d.). 急性髓系白血病 - 癌症统计资料。（无日期）。National Cancer Institute 国家癌症研究所[10] [10]Grand View Research 大视野研究 , Acute Myeloid Leukemia Treatment Market Size, Share & Trends Analysis Report By Disease, By Treatment (Chemotherapy, Targeted Therapy, Immunotherapy), By Route of Administration, By End Use, By Region, And Segment Forecasts, 2025-2030 急性髓系白血病治疗市场规模、份额与趋势分析报告：按疾病、治疗方法（化疗、靶向治疗、免疫治疗）、给药途径、最终用途、地区划分，以及细分市场预测，2025-2030年。[11] [11]Karkempetzaki, A. I., Schatton, T., & Barthel, S. R. (2025). Galectin-9-An emerging Glyco-Immune checkpoint target for cancer therapy. Karkempetzaki, A. I., Schatton, T., & Barthel, S. R. (2025). 半乳糖凝集素-9——一种新兴的癌症治疗糖免疫检查点靶标。International Journal of Molecular Sciences 国际分子科学杂志, ，26 26(16), 7998. (16), 7998。https://doi.org/10.3390/ijms26167998 https://doi.org/10.3390/ijms26167998This information is provided by Reach, the non-regulatory press release distribution service of RNS, part of the 这部分信息由RNS的非监管新闻稿分发服务Reach提供，London Stock Exchange 伦敦证券交易所. Terms and conditions relating to the use and distribution of this information may apply. For further information, please contact 与此信息的使用和分发相关的条款和条件可能适用。欲了解更多信息，请联系rns@lseg.com rns@lseg.comor visit 或访问www.rns.com www.rns.com. 。RNS may use your IP address to confirm compliance with the terms and conditions, to analyse how you engage with the information contained in this communication, and to share such analysis on an anonymised basis with others as part of our commercial services. 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2026-04-22

·BioSpace

PureTech Reports Positive Topline Data from Phase 1b Trial of LYT-200 in Relapsed/Refractory (R/R) High-Risk (HR) Myelodysplastic Syndrome (MDS) and R/R Acute Myeloid Leukemia (AML)

Phase 1b dataset with LYT-200 demonstrates complete responses and favorable tolerability across both R/R HR-MDS and R/R AML PureTech’s Founded Entity, Gallop Oncology, to advance LYT-200 first in R/R HR-MDS, with continued development planned in R/R AML Company plans to engage with the U.S. Food and Drug Administration to discuss the design of a subsequent trial in R/R HR-MDS that has the potential to support registration BOSTON--(BUSINESS WIRE)-- PureTech Health plc (Nasdaq: PRTC, LSE: PRTC) ("PureTech" or the "Company"), a hub-and-spoke biotherapeutics company dedicated to giving life to science and transforming innovation into value, today announced positive topline data from the completed Phase 1b clinical trial of LYT-200, a first-in-class, fully human anti-galectin-9 monoclonal antibody, in heavily pretreated patients with relapsed/refractory (R/R) high-risk (HR) myelodysplastic syndrome (MDS) and R/R acute myeloid leukemia (AML). Based on the results, PureTech’s Founded Entity, Gallop Oncology, has selected a recommended Phase 2 dose (RP2D) and intends to engage with the U.S. Food and Drug Administration (FDA) to discuss the design of a subsequent trial that could potentially support registration of LYT-200 in R/R HR-MDS. “The data from the completed Phase 1b trial highlight the potential for LYT-200 to offer a differentiated treatment approach across a range of myeloid hematological malignancies,” said Aleksandra Filipovic, M.D., Ph.D., Head of Oncology at PureTech and Chief Medical Officer of Gallop Oncology. “Across patients with R/R HR-MDS and R/R AML, treatment with LYT-200 resulted in deep responses with an exceptionally favorable safety profile. Importantly, the data in R/R HR-MDS were particularly compelling and support prioritizing this indication, especially given the significant unmet need and lack of successful innovation to help these patients. We intend to engage with the FDA to discuss the design of a subsequent trial in R/R HR-MDS, as our goal is to accelerate delivery of this promising first-in-class therapy to patients while also laying the foundation for broader clinical development, including in AML.” The completed Phase 1b trial (NCT05829226), conducted across nine U.S. sites, evaluated LYT-200 both as a monotherapy and in combination regimens in two heavily pretreated patient populations. The study included dose escalation of monotherapy LYT-200, followed by dose escalation of LYT-200 in combination with a hypomethylating agent (HMA; azacitidine or decitabine) in patients with R/R HR-MDS and with venetoclax (VEN) and an HMA in R/R AML. “The safety profile, combinatorial potential, and level of clinical activity observed with LYT-200 in this Phase 1b study across both R/R HR-MDS and R/R AML is very encouraging, particularly given the number of prior lines of treatment and the risk pro the populations studied,” said Amir T. Fathi, M.D., Program Director of the Center for Leukemia at the Mass General Brigham Cancer Institute and Professor of Medicine at Harvard Medical School. “In R/R high-risk MDS, where treatment options are extremely limited and outcomes are poor, the findings are particularly notable. In this context, the potential to achieve clinical responses without added toxicity would represent a meaningful advance in the MDS treatment landscape and warrants continued clinical development.” “The results from this Phase 1b trial provide a strong foundation for the next stage of development of LYT-200,” said Eric Elenko, Ph.D., President and Co-founder of PureTech and Acting Chief Executive Officer of Gallop Oncology. “Our decision to prioritize relapsed/refractory high-risk MDS reflects a focused and disciplined approach, grounded in both the data generated to date and the potential to address a tremendous patient need. We intend to engage with the FDA to discuss a subsequent trial design with the potential to support registration, while continuing to evaluate the broader potential of LYT-200.” TOPLINE SAFETY DATA LYT-200 demonstrated a favorable and consistent safety pro all cohorts and dose levels studied (N=101), with no dose-limiting toxicities, infusion-related reactions, LYT-200 dose reductions, or LYT-200-related serious adverse events (AEs), discontinuations, or deaths. Importantly, no overlapping or additive toxicities were observed when LYT-200 was combined with an HMA or VEN/HMA. Six patients at one study site reported experiencing hematology/chemistry-related Grade 3 or 4 AEs attributed as possibly related or related to LYT-200 in the combination arm at the RP2D dose. The reported AEs consisted of decreased levels of platelets, white blood cells, and neutrophils that were below the lower limit of normal physiological levels. The blood count deficits for some of the relevant patients were present at baseline prior to the administration of LYT-200 and are common occurrences in patients due to the underlying advanced MDS/AML, as well as in those receiving VEN/HMA treatment. No other sites reported Grade 3 or greater AEs related to LYT-200 treatment. TOPLINE EFFICACY DATA Treatment with LYT-200 in combination with an HMA in R/R HR-MDS patients and VEN/HMA in R/R AML patients demonstrated robust antileukemic activity, including complete responses, bridging to transplant, and durable clinical benefit. The data also provided important insights into the contribution of LYT-200 within combination regimens. R/R HR-MDS Across all efficacy-evaluable 1 patients (n=11), the recommended Phase 2 dose (LYT-200 12mg/kg in combination with an HMA) demonstrated: 27.3% complete response rate 9.1% partial response rate 9.1% marrow complete response rate 45.5% overall response rate 18% conversion to transplant rate Due to the number of patients alive at the time of study completion (>50%), the upper bound of overall survival could not be calculated; therefore, the median overall survival for this cohort of 6.4 months is not considered fully mature. Efficacy-evaluable patients had a median of 3 prior lines of therapy (range: 1-5), and all (100%) had previously been treated with an HMA. Additionally, all patients had high-risk cytogenetics, which – coupled with prior exposure to treatment – suggests biologically aggressive, treatment-refractory disease with elevated risk of progression and poor clinical outcomes. Taken together, these attributes underscore the potential mutation-agnostic mechanism of LYT-200 and its potential for broad clinical use. R/R AML Across all efficacy-evaluable 1 patients (n=26), LYT-200 12mg/kg in combination with VEN/HMA demonstrated: 30.8% composite complete response rate 2 ; responders included patients with mutations associated with VEN resistance 7.7% partial response rate 42.3% overall response rate 19.2% conversion to transplant rate Due to the number of patients alive at the time of study completion (50%), the upper bound of overall survival could not be calculated; therefore, the median overall survival for this cohort of 8.2 months is not considered fully mature. Efficacy-evaluable patients had a median of 2 prior lines of therapy (range: 1-9), and 84.6% had previously been treated with VEN/HMA. INITIAL PHARMACODYNAMIC FINDINGS The systemic effects of LYT-200 were evaluated through pharmacodynamic analyses of peripheral blood mononuclear cells, a population of immune cells in the bloodstream that provides insight into how a treatment affects both the immune system and leukemic blast cells. These analyses suggest that LYT-200 engages complementary and potentially synergistic pathways directed at cancer cell killing and anti-cancer immune responses when combined with VEN and HMA-based therapy, which may contribute to the clinical activity observed in patients with relapsed/refractory disease following HMA and VEN/HMA treatment, in MDS and AML, respectively. About Myelodysplastic Syndromes Myelodysplastic syndromes (MDS) are a group of serious blood cancers characterized by ineffective blood cell production in the bone marrow, leading to anemia, infections, and bleeding complications. 3, 4 MDS affects approximately 60,000–170,000 people in the United States, with an estimated 30–40% of patients diagnosed with the more aggressive form of the disease known as high-risk (HR) MDS. 3, 5 HR-MDS is associated with poor outcomes, with median survival typically less than two years following diagnosis, and approximately 30% of patients progressing to acute myeloid leukemia (AML). 4-6 The current standard frontline treatment for HR-MDS are hypomethylating agents (HMAs), such as azacitidine and decitabine; however, most patients do not respond to these therapies or eventually stop benefiting from them. 7 Once the disease becomes relapsed or refractory (R/R), outcomes are especially poor, with survival often limited to only a few months. 7,8 Treatment options for patients with R/R HR-MDS remain very limited. Only one therapy has been approved specifically for this setting in the past two decades, and it targets only a small subset of patients (~3–5%) with a specific genetic mutation. 7 As a result, there remains a significant need for new treatment approaches for patients with HR-MDS. About Acute Myeloid Leukemia Acute myeloid leukemia (AML) is an aggressive blood cancer characterized by the rapid growth of abnormal myeloid blast cells in the bone marrow and blood. It is the most common form of acute leukemia in adults, with a five-year survival rate of less than 30%. 9 Despite available therapies, many patients relapse or fail to respond, and outcomes are especially poor in the relapsed/refractory setting. Around 450,000 people globally are living with AML. 9 AML is an area of urgent medical need where new therapies with improved safety, efficacy, and durability or responses are critical. Importantly, the incidence of AML is increasing, and the market is expected to grow to $6 billion annually by 2030, 10 underscoring the scale of the opportunity to bring forward therapies that are not only more effective but also applicable across a broader segment of patients. About LYT-200 LYT-200 is a fully human IgG4 monoclonal antibody in development for the treatment of hematological malignancies. LYT-200 targets galectin-9, which is an important oncogenic driver and potent immunosuppressor in cancer, positioning it as a novel target for cancer therapy. 11 LYT-200 has been granted Fast Track and Orphan Drug designations from the U.S. Food and Drug Administration (FDA) for the treatment of acute myeloid leukemia. About Gallop Oncology Gallop Oncology was founded by and is currently wholly-owned by PureTech Health plc (Nasdaq: PRTC, LSE: PRTC). Gallop is a clinical-stage biopharmaceutical company committed to transforming treatment paradigms for hematologic malignancies. Guided by science and driven to deliver meaningful outcomes for patients, Gallop is advancing a novel approach where efficacy, safety, and durability converge. Its lead candidate, LYT-200, is the most advanced candidate targeting galectin-9, an important oncogenic driver and potent immunosuppressor in cancer, offering a differentiated strategy to address some of the most challenging cancers. For more information, please visit . About PureTech Health PureTech Health is a hub-and-spoke biotherapeutics company dedicated to giving life to science and transforming innovation into value. We do this through a proven, capital-efficient R&D model focused on opportunities with validated pharmacology and untapped potential to address significant patient needs. This strategy has produced dozens of therapeutic candidates, including three that have received U.S. FDA approval. By identifying, shaping, and de-risking these high-conviction assets, and scaling them through dedicated structures backed by external capital, we accelerate their path to patients while creating sustainable value for shareholders. For more information, visit or connect with us on X (formerly Twitter) @puretechh. Cautionary Note Regarding Forward-Looking Statements This press release contains statements that are or may be forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements contained in this press release that do not relate to matters of historical fact should be considered forward-looking statements, including without limitation those related to the LYT-200 development program and development plans, its potential benefits to patients, plans for discussions with regulatory authorities, the further development of the program, future presentation of additional data from the program and our future prospects, developments and strategies. The forward-looking statements are based on current expectations and are subject to known and unknown risks, uncertainties and other important factors that could cause actual results, performance and achievements to differ materially from current expectations, including, but not limited to, those risks, uncertainties and other important factors described under the caption "Risk Factors" in our Annual Report on Form 20-F for the year ended December 31, 2024, filed with the SEC and in our other regulatory filings. These forward-looking statements are based on assumptions regarding the present and future business strategies of the Company and the environment in which it will operate in the future. Each forward-looking statement speaks only as at the date of this press release. Except as required by law and regulatory requirements, we disclaim any obligation to update or revise these forward-looking statements, whether as a result of new information, future events or otherwise. 1 Efficacy evaluable is defined in the protocol as all patients who received a minimum one full cycle of LYT-200 (four doses) and had a minimum of one post-baseline disease assessment. The intent-to-treat population for the R/R HR-MDS cohort was n=12 and for the R/R AML cohort was n=33. 2 Complete response + complete response with incomplete hematological recovery 3 American Cancer Society. (2023). What Is Myelodysplastic Syndrome? Retrieved from 4 National Comprehensive Cancer Network. (2024). NCCN Clinical Practice Guidelines in Oncology: Myelodysplastic Syndromes (Version 2.2024). Retrieved from 5 Greenberg, P. L., Tuechler, H., Schanz, J., Sanz, G., Garcia-Manero, G., Solé, F., Bennett, J. M., Bowen, D., Fenaux, P., Dreyfus, F., Kantarjian, H., Kuendgen, A., Levis, A., Malcovati, L., Cazzola, M., & Haase, D. (2012). Revised International Prognostic Scoring System for myelodysplastic syndromes. Blood, 120 (12), 2454–2465. 6 Ma, X. (2012). Epidemiology of myelodysplastic syndromes. The American Journal of Medicine, 125 (7 Suppl), S2–S5. 7 Garcia-Manero, G., Fenaux, P., Al-Kali, A., Baer, M. R., Sekeres, M. A., Roboz, G. J., et al. (2016). Rigosertib versus best supportive care for patients with high-risk myelodysplastic syndromes after failure of hypomethylating drugs (ONTIME): A randomised, controlled, phase 3 trial. Lancet Oncology, 17(4), 496–508. (16)00009-7 8 Prébet, T., Gore, S. D., Esterni, B., Gardin, C., Itzykson, R., Thepot, S., Quesnel, B., Dreyfus, F., Beyne-Rauzy, O., Vey, N., Recher, C., Adès, L., Fenaux, P., & Groupe Francophone des Myélodysplasies. (2011). Outcome of patients with higher-risk myelodysplastic syndromes after azacitidine treatment failure. Journal of Clinical Oncology, 29 (24), 3322–3327. 9 Acute Myeloid Leukemia - Cancer Stat Facts. (n.d.). National Cancer Institute 10 Grand View Research, Acute Myeloid Leukemia Treatment Market Size, Share & Trends Analysis Report By Disease, By Treatment (Chemotherapy, Targeted Therapy, Immunotherapy), By Route of Administration, By End Use, By Region, And Segment Forecasts, 2025-2030 11 Karkempetzaki, A. I., Schatton, T., & Barthel, S. R. (2025). Galectin-9—An emerging Glyco-Immune checkpoint target for cancer therapy. International Journal of Molecular Sciences , 26 (16), 7998. Contacts PureTech Public Relations publicrelations@puretechhealth.com Investor Relations IR@puretechhealth.com UK/EU Media Ben Atwell, Rob Winder +44 (0) 20 3727 1000 puretech@fticonsulting.com US Media Justin Chen jchen@tenbridgecommunications.com

临床结果快速通道临床1期孤儿药免疫疗法

2026-04-16

·BioSpace

Traws Pharma Reports Full Year 2025 Results and Provides Business Highlights

Tivoxavir marboxil advancing towards a human influenza challenge trial as a once-monthly prophylactic agent, building on broad preclinical antiviral activity, Ratutrelvir topline Phase 2a data show a differentiated pro PAXLOVID ® in COVID patients, with good overall safety; final study analysis underway Private financing of up to $60M (with $10M of such amount upfront) offering of common stock and milestone-based and three-year warrants completed on April 15, 2026 supporting operations into Q1 2027 Investor Update call today, April 15, 2026 at 4:30 PM ET NEWTOWN, Pa., April 15, 2026 (GLOBE NEWSWIRE) -- Traws Pharma, Inc. (NASDAQ: TRAW) (“Traws Pharma”, “Traws” or “the Company”), a clinical-stage biopharmaceutical company developing novel therapies to target critical threats to human health from respiratory viral diseases, today reported financial results for the year ended December 31, 2025 and provided recent business highlights including updates for the Company’s lead investigational program: tivoxavir marboxil (TXM) in development for influenza prophylaxis and treatment, and completion of a private investment in public equity (PIPE) financing providing up to $60 million in gross proceeds, including $10 million in gross proceeds at closing. The financing, plus current cash and cash equivalents, is expected to provide sufficient resources to support Company operations into Q1 2027, including completion of the planned Phase 2a single-dose human Challenge Trial for TXM as a once-monthly oral prophylactic agent for influenza prevention (“Challenge Trial”). “Traws has made substantial progress over the last year, towards our goal of advancing our potential best-in-class influenza program as a prophylactic agent. The bridging study for the new compressed tablet formulation is currently underway in Australia. In parallel, the Company expects the planned Challenge Trial to proceed as scheduled in the second quarter of 2026, subject to formal approval from the United Kingdom Medicines and Healthcare products Regulatory Agency (“MHRA”). Additionally, we are actively engaging with the U.S. Food and Drug Administration to resolve the clinical hold and support advancement of the TXM program in the U.S.,” commented Iain Dukes, MA, DPhil, Chief Executive Officer of Traws Pharma. “The capital from the recent private financing, supported by a group of new and existing investors, positions Traws to complete the Challenge Trial, while preserving access to substantial additional capital as key milestones are achieved.” Conference Call and Webcast Information Date: Wednesday, April 15, 2026, at 4:30 PM ET Participant Dial-in (U.S.): 1-877-407-0789 Participant Dial-in (International): 1-201-689-8562 Webcast Access: Click Here A replay of the webcast will be available on the Investors section of the Traws website at . Recent Highlights and Anticipated Milestones: $60 Million Private Financing On April 15, 2026, TRAW announced an up to $60 million PIPE financing including initial funding of $10 million in gross proceeds at closing, with up to approximately $50 million of additional potential gross proceeds from milestone-based and three-year warrants. The financing consists of the sale of 5,982,919 shares of common stock (or pre-funded warrants in lieu thereof) at a purchase price of $1.6730 per share, with the warrant exercise price equal to the deal price, as follows: Series A milestone-based warrant with an aggregate exercise price of $10.0 million that becomes exercisable upon receipt of approval from MHRA to conduct the challenge trial. Series B milestone-based warrant with an aggregate exercise price of $10.0 million that becomes exercisable following both shareholder approval and the announcement of data from the challenge trial. Series C common warrants with a three-year term to purchase shares of our common stock and providing potential additional gross proceeds of $30.0 million if fully exercised following shareholder approval. The upfront gross proceeds and milestone-based warrants, along with the current cash and cash equivalents, are estimated to provide sufficient resources to fund company operations into Q1 2027 including completion of a human challenge trial for TXM as a once-monthly prophylactic agent for influenza prevention. The terms of the financing are described in more detail in the Company’s current report on Form 8-K filed in connection with the financing on April 15, 2026. Investigational Programs: Tivoxavir Marboxil (TXM, influenza): Intended Indication and Market Potential : Potential as a best-in-class once-monthly prophylactic or treatment for seasonal flu and pandemic/bird flu, estimated to be a multi-billion dollar opportunity, including potential for stockpiling and pandemic preparedness initiatives. 1,2 Recent Developments : New Formulation Supports Planned Prophylactic Treatment Study Recently completed preclinical studies show that the new TXM compressed tablet formulation provides longer exposure and extended coverage against influenza. This new formulation, coupled with broad preclinical activity previously demonstrated against a wide range of influenza strains, including all influenza A and B strains, supports TXM’s potential use as a once-monthly prophylactic treatment for seasonal flu. Traws also continues to advance the program for TXM as a single-dose oral therapy for seasonal flu or H5N1 bird flu, including efforts to secure formal consideration by the Biomedical Advanced Research and Development Authority (BARDA) for inclusion in the U.S. stockpile, with a focus on resolving the clinical hold by the U.S. FDA. Next Steps: Completion of Phase 1 Bridging Study – The ongoing Phase 1 bridging study, being conducted under an open IND in Australia, is intended to recapitulate the preclinical data and confirm that the new compressed tablet formulation can provide 28-days of coverage, enabling TXM’s use as a once-monthly prophylactic treatment. MHRA Approval and Initiation of Challenge trial – TRAW will conduct a single-dose influenza virus challenge trial of TXM at hVIVO, in the UK, following completion of the Phase 1 Bridging study and receipt of MHRA approval. hVIVO is global leader in the conduct of human challenge studies for infectious diseases and respiratory viruses. Efforts Ongoing to Resolve the Clinical Hold – FDA informed the Company that its U.S. IND for TXM has been placed on clinical hold due to concerns with the toxicology data package. The Company plans to engage with the FDA to address the clinical hold and is working to develop and submit a comprehensive response, with the goal of resolving the hold and advancing the program in the U.S. during 2026. Ratutrelvir (COVID): Intended Indication and Market Potential : Potential as a once-daily, ritonavir-independent oral Main protease (Mpro) inhibitor for the treatment of acute COVID infection in a broad range of patients, including those who are PAXLOVID ® -ineligible, with potential to reduce the risk of COVID rebound and Long COVID, estimated to be a multi-billion dollar opportunity. 3 Recent Developments: Positive Phase 2a Results Traws is completing final analysis of the 90-patient Phase 2a study. Topline data demonstrated safety and proof-of-concept efficacy for ratutrelvir in PAXLOVID ® -eligible and PAXLOVID ® -ineligible patients. Patients ineligible to receive PAXLOVID ® are frequently at elevated risk for severe disease and require suitable, safe and effective treatment options. Ratutrelvir has the potential to address this gap in care and may be a valuable therapeutic option. The Phase 2a study was designed as an active-controlled comparator trial versus PAXLOVID ® (nirmatrelvir/ritonavir), evaluating patient-reported symptom outcomes, safety, and real-world usability. A separate treatment arm was comprised of patients ineligible for ritonavir-boosted regimens due to contraindications or clinically significant drug–drug interactions. Topline data showed: Efficacy : Ratutrelvir demonstrated equivalent time to sustained treatment resolution with no viral rebounds in PAXLOVID ® eligible subjects. The study also showed that treatment with ratutrelvir produced faster symptom resolution in PAXLOVID ® -ineligible patients (HR, 1.31; 95% CI, 0.78-2.20, p=0.018). Safety : Ratutrelvir demonstrated favorable overall safety, with fewer treatment related adverse events compared to PAXLOVID ® . Next Steps: Phase 2 Data Support Further Development of Ratutrelvir – Traws plans to use the resulting data from the final analysis of the Phase 2a study to inform next steps for its clinical and regulatory strategy. Corporate Updates : John Leaman, MD, named Independent Board Director on October 6, 2025, bringing significant expertise in finance, M&A and corporate strategy. Appointment of Iain Dukes, MA, D Phil, as CEO, and Charles Parker, as CFO, confirmed by the Board on October 6, 2025. Financial Results: Cash and cash equivalents: As of December 31, 2025, the Company had cash and cash equivalents of approximately $3.8 million, compared to approximately $21.3 million as of December 31, 2024, excluding gross proceeds of up to approximately $60 million for a PIPE financing and milestone-based and three-year warrants which the Company completed on April 15, 2026, with funding thereunder expected April 16, 2026. Based on current plans, the Company believes that its current cash balance, including net proceeds from the offering and milestone-based warrants, is sufficient to support planned expenses, including completion of the Challenge Study, into Q1 2027. Revenue for the year ended December 31, 2025, was $2.8 million, compared to $0.2 million for the comparable period in 2024. The increase in 2025 revenue was due to the recognition of deferred revenue as a result of the termination of the Symbio license agreement. Acquired in-process research and development expense for the year ended December 31, 2025 was zero compared to $117.5 million for the comparable period in 2024, recognized related to virology programs acquired in connection with the acquisition of Trawsfynydd through a merger. Research and development (R&D) expense for the year ended December 31, 2025, totaled $12.1 million, compared to $12.8 million for the comparable period in 2024. This decrease of $0.7 million primarily relates to a decrease in expenses related to the oncology programs, partially offset by an increase in expenses related to the virology programs. General and administrative (G&A) expense for the year ended December 31, 2025, totaled $8.5 million, compared to $12.3 million for the comparable period in 2024. This decrease of $3.8 million was primarily attributable to a decrease in professional and consulting fees. Net Income (loss): The net income for the year ended December 31, 2025 was $9.2 million, or net income of $0.83 per basic common and $0.82 per diluted common share. This compares to net loss of $166.5 million, or a net loss of $35.21 per basic and diluted common share, for the year ended December 31, 2024. Shares Outstanding: Traws had 10,157,257 shares of common stock outstanding as of April 14, 2026. About Tivoxavir Marboxil Tivoxavir marboxil (TXM) is an investigational oral, small molecule CAP-dependent endonuclease inhibitor designed to be administered as a single-dose agent for prophylactic use or treatment of seasonal influenza and pandemic/bird flu. It has shown potent in vitro activity against a range of influenza strains in preclinical studies, including a human isolate of the highly pathogenic avian flu H5N1 (bird flu). Consistent, positive preclinical data from three animal species indicate that a single dose of TXM demonstrated a therapeutic effect against H5N1 bird flu. Seasonal influenza represents an estimated multi-billion dollar antiviral market opportunity, largely driven by global health organizations, practice guidelines and government tenders and inclusion in drug stock piling initiatives 1,2 , with upside potential from potential pandemic flu outbreaks including H5N1 bird flu. About Ratutrelvir Ratutrelvir is an investigational oral, small molecule Mpro (3CL protease) inhibitor designed to be a broadly acting treatment for SARS-CoV-2/COVID-19 that is used without ritonavir. It has demonstrated in vitro activity against a range of virus strains. Preclinical and Phase 1 studies show that ratutrelvir does not require co-administration with a metabolic inhibitor, such as ritonavir, which could avoid ritonavir-associated drug-drug interactions 4 , and potentially enable wider patient use. Phase 1 data also show that ratutrelvir’s pharmacokinetic (PK) pro maintenance of target blood plasma levels approximately 13 times above the EC 50 using the target Phase 2 dosing regimen of 600 mg/day for ten days, which may also reduce the likelihood of clinical rebound and, consequently, reduce the risk for Long COVID 5 . Industry data indicate that COVID treatment represents a potential multi-billion dollar market opportunity 3 . Source information Per link Traws data on file Pfizer Inc. annual report on Form 10-K for the fiscal year ended December 31, 2025, filed with the U.S. Securities and Exchange Commission on February 3, 2026 Carly Herbert et al. (2025) Clinical Infectious Diseases. Third-party products mentioned herein are the trademarks of their respective owners. About Traws Pharma, Inc. Traws Pharma is a clinical stage biopharmaceutical company dedicated to developing novel therapies to target critical threats to human health in respiratory viral diseases. Traws integrates antiviral drug development, medical intelligence and regulatory strategy to meet real world challenges in the treatment of viral diseases. We are advancing novel investigational oral small molecule antiviral agents that have potent activity against difficult to treat or resistant virus strains that threaten human health: seasonal influenza and H5N1 bird flu, and COVID-19/Long COVID. Tivoxavir marboxil is in development as a once-monthly oral prophylactic agent for influenza prevention, with additional potential as a single-dose therapy for seasonal flu or H5N1 bird flu, targeting the influenza cap-dependent endonuclease (CEN). Ratutrelvir is in development as a ritonavir-independent COVID treatment, targeting the Main protease (Mpro or 3CL protease). Traws is actively seeking development and commercialization partners for its legacy clinical oncology programs, rigosertib and narazaciclib. More details can be found on Traws’ website at . For more information, please visit and follow us on LinkedIn. Forward-Looking Statements Some of the statements in this release are forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, Section 21E of the Securities Exchange Act of 1934, as amended, and the Private Securities Litigation Reform Act of 1995, and involve risks and uncertainties including statements regarding the Company, its business and product candidates, including the potential opportunity, market size, benefits, effectiveness, safety, and the clinical and regulatory plans for tivoxavir marboxil and ratutrelvir, as well as plans for its legacy programs. The Company has attempted to identify forward-looking statements by terminology including “believes”, “estimates”, “anticipates”, “expects”, “plans”, “intends”, “may”, “could”, “might”, “will”, “should”, “preliminary”, “encouraging”, “approximately” or other words that convey uncertainty of future events or outcomes. Although Traws believes that the expectations reflected in such forward-looking statements are reasonable as of the date made, expectations may prove to have been materially different from the results expressed or implied by such forward looking statements. These statements are only predictions and involve known and unknown risks, uncertainties, and other factors, including the outcome of Traws’ IND filing with the FDA for tivoxavir marboxil, including the current FDA clinical hold; the success and timing of Traws’ clinical trials; the potential efficacy of ratutrelvir for the treatment of COVID-19, including the potential to reduce the risk of COVID rebound and Long COVID; the potential for ratutrelvir to gain market acceptance, if and when regulatory approval is obtained, or to become the new standard of care; Traws’ interactions with the FDA, BARDA and similar foreign regulators; collaborations; market conditions; regulatory requirements and pathways for approval; the ongoing need for improved therapy to reduce the frequency of clinical rebound and the concomitant risk for Long COVID; the extent of the spread and threat of the bird flu; the Company’s cash projections; Traws’ ability to raise additional capital when needed; and those discussed under the heading “Risk Factors” in Traws’ filings with the U.S. Securities and Exchange Commission (SEC). Any forward-looking statements contained in this release speak only as of its date. Traws undertakes no obligation to update any forward-looking statements contained in this release to reflect events or circumstances occurring after its date or to reflect the occurrence of unanticipated events, except to the extent required by law. Traws Pharma Contact: Charles Parker Traws Pharma, Inc. cparker@trawspharma.com Investor Contact: John Fraunces LifeSci Advisors, LLC 917-355-2395 jfraunces@lifesciadvisors.com Traws Pharma, Inc. Condensed Consolidated Balance Sheets December 31, 2025 2024 Assets Current assets: Cash and cash equivalents $ 3,820,000 $ 21,338,000 Tax incentive and other receivables 3,794,000 1,765,000 Prepaid expenses and other assets 365,000 1,848,000 Total current assets 7,979,000 24,951,000 Property and equipment, net 7,000 10,000 Intangible assets, net 2,527,000 — Other assets 104,000 1,000 Total assets $ 10,617,000 $ 24,962,000 Liabilities and stockholders’ deficit Current liabilities: Accounts payable $ 5,653,000 $ 8,186,000 Accrued expenses and other liabilities 5,493,000 3,121,000 Deferred revenue — 226,000 Total current liabilities 11,146,000 11,533,000 Deferred revenue, non-current — 2,565,000 Warrant liabilities 100,000 42,494,000 Total liabilities 11,246,000 56,592,000 Commitments and contingencies (Note 6) Stockholders’ deficit: Series C Preferred stock, $0.01 par value, 5,000,000 shares authorized, 7,440 shares issued and 6,737 shares outstanding at December 31, 2025 and 7,440 shares issued and 7,398 outstanding at December 31, 2024 — — Common stock, $0.01 par value, 250,000,000 shares authorized, 9,067,774 and 3,650,731 shares issued and outstanding at December 31, 2025 and December 31, 2024, respectively 90,000 36,000 Additional paid in capital 639,259,000 617,530,000 Accumulated deficit (639,984,000 ) (649,154,000 ) Accumulated other comprehensive income (loss) 6,000 (42,000 ) Total stockholders’ deficit (629,000 ) (31,630,000 ) Total liabilities and stockholders’ deficit $ 10,617,000 $ 24,962,000 Traws Pharma, Inc. Condensed Consolidated Statements of Operations Years ended December 31, 2025 2024 Revenue $ 2,790,000 $ 226,000 Operating expenses: Acquired in-process research and development — 117,464,000 Research and development 12,143,000 12,847,000 General and administrative 8,522,000 12,289,000 Total operating expenses 20,665,000 142,600,000 Loss from operations (17,875,000 ) (142,374,000 ) Change in fair value of warrant liability 26,567,000 — Series A warrant and pre-funded warrant expense — (24,438,000 ) Other income, net 478,000 289,000 Net income (loss) $ 9,170,000 $ (166,523,000 ) Net income (loss) attributable to common stockholders, basic and diluted $ 6,865,000 $ (54,674,000 ) Weighted-average shares of common stock outstanding, basic 8,228,169 1,552,685 Net income (loss) per share of common stock, basic $ 0.83 $ (35.21 ) Weighted-average shares of common stock outstanding, diluted 8,376,380 1,552,685 Net income (loss) per share of common stock, diluted $ 0.82 $ (35.21 ) Net income (loss) attributable to Series C Preferred stockholders, basic and diluted $ 2,305,000 $ (111,849,000 ) Weighted-average shares of Series C Preferred outstanding, basic and diluted 6,906 7,941 Net income (loss) per share of Series C Preferred, basic and diluted $ 333.77 $ (14,085.00 )

100 项与瑞格色替相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D10155	瑞格色替	-	DB12146

研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
转移性胰腺癌	临床3期	美国	Traws Pharma, Inc.	2011-05-01
转移性胰腺癌	临床3期	匈牙利	Traws Pharma, Inc.	2011-05-01
转移性胰腺癌	临床3期	印度	Traws Pharma, Inc.	2011-05-01
转移性胰腺癌	临床3期	俄罗斯	Traws Pharma, Inc.	2011-05-01
转移性胰腺癌	临床3期	乌克兰	Traws Pharma, Inc.	2011-05-01
转移性胰腺腺癌	临床3期	美国	Traws Pharma, Inc.	2011-05-01
转移性胰腺腺癌	临床3期	匈牙利	Traws Pharma, Inc.	2011-05-01
转移性胰腺腺癌	临床3期	印度	Traws Pharma, Inc.	2011-05-01
转移性胰腺腺癌	临床3期	俄罗斯	Traws Pharma, Inc.	2011-05-01
转移性胰腺腺癌	临床3期	乌克兰	Traws Pharma, Inc.	2011-05-01

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT05764395 (CTgov)	临床2期	难治性黑色素瘤 \| 皮肤黑色素瘤 \| 转移性黑色素瘤 ... 更多	7	Biopsy+Rigosertib+Pembrolizumab	夢願繭夢衊齋獵鹹壓選 = 獵遞選艱選夢膚鹹願願壓鹹繭壓繭鏇選鑰製壓 (簾選淵願鹽衊壓艱網壓, 壓糧齋膚廠窪築積鹽餘 ~ 獵鏇壓鹹遞網鬱獵壓鏇) 更多	-	2026-09-16
PB2774 (EHA2025)	临床1/2期	骨髓增生异常综合征	770	Rigosertib	鬱夢壓選鹹廠艱憲簾構(積鏇構壓願觸範醖鹽鏇) = 鬱夢觸簾廠遞襯醖鏇選窪衊鹹鹽淵鹽觸鬱廠構 (艱廠齋獵窪鏇餘範選膚, 0.012 ~ 0.039) 更多	积极	2025-05-14
NCT04263090 (Corporate Publications) 人工标引	临床1/2期	KRAS突变非小细胞肺癌 KRAS Mutation	19	Rigosertib+nivolumab	壓糧簾顧鹹簾憲鹹鏇夢(襯膚膚蓋窪鏇鑰築範糧) = 繭齋構鑰獵夢鑰鹽獵遞壓構窪積齋願築鑰遞積 (廠衊網憲願繭網糧積齋 ) 更多	积极	2022-09-12
NCT04263090 (ESMO2022)	临床1/2期	KRAS突变非小细胞肺癌二线	18	Rigosertib+Nivolumab	淵願糧願鬱鹽製艱顧積(構壓築窪積蓋壓醖艱鬱) = dysuria/hematuria (65%) 襯範醖築鏇鏇鏇齋夢顧 (鑰簾壓範糧壓鏇淵遞遞 ) 更多	积极	2022-09-10
NCT04263090 (GlobeNewswire) 人工标引	临床1/2期	RAS阳性非小细胞肺癌 KRAS Positive	12	Rigosertib Sodium+Nivolumab	襯築廠範製蓋獵廠憲遞(餘願範醖構製觸遞鬱鑰) = 網醖簾憲衊鬱製窪顧壓壓獵網餘製築醖艱鑰鹽 (鬱鏇築構鏇醖網衊構衊 ) 更多	积极	2021-09-22
NCT02730884 (CTgov)	临床2期	贫血 \| 原发性血小板增多症后骨髓纤维化 \| 骨髓纤维化 ... 更多	3	Questionnaire+Rigosertib	獵膚糧鬱膚廠廠願遞製 = 顧願簾艱艱淵廠醖願壓積網襯顧網夢醖廠範簾 (艱醖醖顧願築夢製夢積, 憲鏇艱衊鬱選簾築蓋醖 ~ 製齋衊膚獵淵顧廠廠壓) 更多	-	2020-08-07
NCT01926587 (Pubmed \| Leuk Res) 人工标引	临床1期	急性髓性白血病 \| 骨髓增生异常综合征	18	azacitidine+Rigosertib	選膚鹹廠憲膚鑰獵願鑰(鹽壓獵窪觸鑰壓齋淵願) = 顧觸醖衊鬱夢襯艱淵鬱製夢願膚積積觸蓋積衊 (遞築糧網遞積鏇範廠膚 ) 更多	积极	2020-07-01
ASH 12019 \| ASH 22019 人工标引	临床2期	骨髓增生异常综合征一线	-	Azacitidine+rigosertib	壓鏇齋衊鬱構齋簾艱顧(襯選簾衊齋遞觸觸網壓) = 26% [urinary tract pain (2), and 1 each for urinary retention, hematuria, hydronephrosis, osteolysis, cerebral haemorrhage, WBC count decreased, neutrophil count decreased, & abd pain] 鑰艱衊蓋築衊醖範網齋 (艱廠壓觸齋蓋觸構鹹襯 )	积极	2019-11-13
EHA2019	临床1/2期	高危骨髓增生异常综合征	-	Oral rigosertib + Azacitidine	獵齋願築鬱獵遞鏇選鑰(夢窪醖廠齋艱製願蓋觸) = dysuria 糧網壓築獵衊願齋憲夢 (願窪衊鏇築夢憲壓願鏇 ) 更多	-	2019-06-15
NCT00854646 (Pubmed) 人工标引	临床1/2期	急性髓性白血病 \| 骨髓增生异常综合征	22	rigosertib	鏇築夢獵構憲網糧繭繭(築簾鑰構範衊壓鏇鏇壓) = fatigue, diarrhea, pyrexia, dyspnea, insomnia, and anemia. 憲醖觸鏇廠製憲襯餘餘 (鑰築鹽衊夢遞積願蓋簾 )	积极	2018-01-01