ARC-100

Newly formed executive team initiates global search for differentiated therapeutic assets for neurology and oncology indications, two of biopharma's largest and fastest-growing markets Strategic transformation driven by a comprehensive data analysis will enable new executive team to leverage decades of experience in these therapeutic areas Company pivoting from a singular focus on glioblastoma and will explore out-licensing of legacy assets berubicin and TPI 287 HOUSTON, TX / ACCESS Newswire / March 11, 2026 / CNS Pharmaceuticals, Inc. (NASDAQ:CNSP) (the "Company"), a biotechnology company focused on building a pipeline of innovative therapies in high-value neurology and oncology markets, today announced that it has launched a new corporate growth strategy designed to build a high-value pipeline in neurology and oncology. The strategy is being led by the newly formed executive team with deep experience across neurology, oncology and rare disease drug development. The team is driving a disciplined, data-driven approach to identify, acquire and advance differentiated therapeutic programs capable of delivering meaningful clinical and commercial value. CNS Pharmaceuticals conducted an independent, rigorous evaluation of its existing pipeline, development priorities and broader market opportunities as part of a comprehensive strategic review. The process incorporated clinical probability-of-success modeling, competitive landscape assessments, regulatory pathway evaluations and risk-adjusted return analyses. The review was carried out in collaboration with external strategic advisors to ensure a disciplined, scientifically grounded and commercially focused path forward. Rami Levin, President and Chief Executive Officer of CNS Pharmaceuticals, commented, "We have made impactful progress in a very short period of time and are expecting 2026 to be a year of transformation and execution for CNS Pharmaceuticals. In parallel to a hand-picked, newly formed executive team, we immediately engaged a preeminent consulting firm and have now completed a robust and highly analytical review of our pipeline, development priorities and long-term positioning. We believe CNS Pharmaceuticals is uniquely positioned to leverage the deep expertise of our leadership team and a disciplined approach to capital allocation to build a next-generation biotechnology company focused on high-value opportunities in neurology and oncology." Based on the outcome of this review, the Company is moving towards a defined strategic focus on acquiring or in-licensing preclinical and clinical-stage assets in the therapeutic areas of neurology and oncology. CNS Pharmaceuticals intends to prioritize programs with strong biological rationale, differentiated mechanisms of action, clearly defined development and regulatory pathways and compelling clinical and commercial potential. Particular emphasis will be placed on assets with defined value inflection points and those addressing areas of significant unmet medical need, positioning the Company's pipeline for long-term growth and value creation. Neurology and oncology remain two of the most active and rapidly advancing sectors in biotechnology, supported by large and growing global markets, significant scientific innovation and well-established regulatory frameworks that can accelerate development timelines. Mr. Levin added, "Strategic transformations are a common and often successful approach in biotechnology. With the right leadership experience and a disciplined, data-driven strategy, companies can transform their pipelines and create substantial value. We believe CNS Pharmaceuticals is now prepared to follow this model as we identify, secure and advance differentiated neurology and oncology assets." As part of the strategic review, CNS Pharmaceuticals also evaluated its legacy programs. While scientifically valuable, TPI 287 and berubicin do not align with the Company's forward-looking growth strategy. CNS Pharmaceuticals plans to prepare comprehensive partnering packages to explore potential out-licensing of these assets, enabling the Company to concentrate its resources on advancing a new acquisition-driven pipeline. About CNS Pharmaceuticals, Inc. CNS Pharmaceuticals is a biotechnology company focused on developing innovative therapies for serious diseases in neurology and oncology. With an experienced executive team and a focus on high-value therapeutic opportunities, the Company is working to build a differentiated portfolio of assets addressing significant unmet medical needs. CNS Pharmaceuticals is committed to advancing novel treatments that have the potential to improve patient outcomes while creating long-term value for patients and shareholders. For more information, please visit , and connect with the Company on X and LinkedIn . Forward-Looking Statements Some of the statements in this press release are forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, Section 21E of the Securities Exchange Act of 1934 and the Private Securities Litigation Reform Act of 1995, which involve risks and uncertainties. Forward-looking statements in this release include, without limitation, statements regarding the Company's pipeline prioritization and strategic development, the anticipated contributions of the new management team to the Company's growth, expectations regarding clinical development and regulatory strategy, and the Company's plans to explore out-licensing or strategic sales of legacy assets. These statements relate to future events, future expectations, plans and prospects. Although CNS Pharmaceuticals believes the expectations reflected in such forward-looking statements are reasonable as of the date made, expectations may prove to have been materially different from the results expressed or implied by such forward-looking statements. CNS Pharmaceuticals has attempted to identify forward-looking statements by terminology including ''believes,'' ''estimates,'' ''anticipates,'' ''expects,'' ''plans,'' ''projects,'' ''intends,'' ''potential,'' ''may,'' ''could,'' ''might,'' ''will,'' ''should,'' ''approximately'' or other words that convey uncertainty of future events or outcomes to identify these forward-looking statements. These statements are only predictions and involve known and unknown risks, uncertainties and other factors, including market and other conditions and those discussed under Item 1A. "Risk Factors" in CNS Pharmaceuticals' most recently filed Form 10-K filed with the Securities and Exchange Commission ("SEC") and updated from time to time in its Form 10-Q filings and in its other public filings with the SEC. Any forward-looking statements contained in this press release speak only as of its date. CNS Pharmaceuticals undertakes no obligation to update any forward-looking statements contained in this press release to reflect events or circumstances occurring after its date or to reflect the occurrence of unanticipated events, except as required by law. CONTACTS: Investor Relations Contact JTC Team, LLC Jenene Thomas 908.824.0775 CNSP@jtcir.com Business Development Contact CNS Pharmaceuticals, Inc. Dylan Wenke, Chief Business Officer dwenke@cnspharma.com SOURCE: CNS Pharmaceuticals, Inc. View the original press release on ACCESS Newswire

Newly Appointed President & Chief Executive Officer, Rami Levin, Discusses Plans for a New Era at CNS Pharmaceuticals Strategic Focus, Pipeline Optimization and Formalizing Roadmap for Near and Long-Term Value Creation HOUSTON, TX / ACCESS Newswire / January 27, 2026 / CNS Pharmaceuticals, Inc. (NASDAQ:CNSP) ("CNS" or the "Company"), a biopharmaceutical company specializing in the development of novel treatments for primary and metastatic cancers in the brain and central nervous system, today issued a Letter to Shareholders from its newly appointed President and Chief Executive Officer, Rami Levin. Dear Fellow Shareholders, I am honored to write to you for the first time in my role as President and Chief Executive Officer of CNS Pharmaceuticals. I have stepped into this role with deep respect for the science, the people, and the shareholders who have supported this Company to date. CNS Pharmaceuticals was founded with a vision to address life threatening diseases with a high unmet medical need, and our focus now is to pursue that mission with clarity, discipline, and a strong commitment to execution and value creation for our shareholders. Strategic Imperative: Evaluation with Purpose Since joining CNS Pharmaceuticals as President & CEO, I have commenced a comprehensive evaluation of the company. This includes a thorough review of our pipeline, development priorities, operational structure, and capital allocation strategy. This process is not about narrowing our ambitions. It is about sharpening them with strategic intent to ensure that our Company is positioned to pursue meaningful, high-value therapeutic opportunities where we believe we can deliver real patient impact and robust long-term shareholder returns. Our evaluation will be guided by three core principles: Patients First. Every program we advance must address a serious condition with clear unmet medical need grounded in strong scientific and commercial rationale, a credible path to meaningful clinical benefit, and a realistic opportunity to improve patient outcomes. Pipeline Enrichment and Optimization. Alongside evaluating opportunities to enhance the pipeline through prioritization and business development opportunities, we are equally focused on optimizing our TPI 287 program. This includes honing the development and regulatory strategies for TPI 287 to ensure they are positioned as efficiently and effectively as possible for clinical advancement and a successful outcome. Disciplined Value Creation. We recognize the responsibility we have to our shareholders. Capital efficiency, milestone-driven execution, and transparent communication will be central to how we operate and make decisions. TPI 287: Our Lead Asset and Core Value Driver At the center of our strategy is TPI 287, our current lead asset and most significant potential value driver. TPI 287 has demonstrated meaningful data and promise in difficult-to-treat CNS and neuro-oncology indications, and we believe its potential has not yet been fully realized. Our focus now is on formalizing a development and regulatory pathway designed to create shareholder value by maximizing the probability of success while minimizing unnecessary risk. This includes: Refining clinical development plans with clear decision points Aligning with regulatory authorities Prioritizing indications and trial designs that offer the most efficient path to value Applying a disciplined, data-driven approach to capital allocation Raising capital towards data and pipeline milestone achievements Our goal is to make smart progress that builds credibility, optionality, and shareholder confidence. Strengthening the Roadmap Our task is to sharpen execution by aligning our capital and human resources, initially around TPI 287. At the same time, we will continue to evaluate opportunities to broaden and strengthen the pipeline in high-value indications where CNS Pharmaceuticals can build a differentiated and durable position. The potential expansion of our pipeline will be deliberate and strategy led. New programs and assets will be evaluated and selected based on their alignment with the Company's long-term strategic direction and how we intend to build and position the Company. Looking Ahead I firmly believe that with focus and a disciplined strategy, we can unlock our full potential and create meaningful value for patients and shareholders alike. As we move forward, our priority is to transform how CNS Pharmaceuticals operates by sharpening our focus, strengthening execution and ensuring that every decision we make is aligned with creating long-term value for our shareholders. In the near term, you can expect clear, consistent communication as we outline our strategy and demonstrate progress. We are committed to growing CNS Pharmaceuticals into a company defined by transparency, momentum and opportunity, and we believe the actions we are taking today position us well for the next phase of value creation. Thank you for your continued support and confidence. I look forward to keeping you informed as we progress through this evaluation process and work together to build the next chapter of CNS Pharmaceuticals. Sincerely, Rami Levin President and Chief Executive Officer About CNS Pharmaceuticals, Inc. CNS Pharmaceuticals is a clinical-stage pharmaceutical company developing a pipeline of anti-cancer drug candidates for the treatment of primary and metastatic cancers of the brain and central nervous system. The Company's drug candidate TPI 287 is an abeotaxane, which stabilizes microtubules and inhibits cell division, causing apoptosis and cell death. The initial clinical efficacy data suggest TPI 287 has the potential to cross the blood-brain barrier and treat CNS tumors. TPI 287 also has been tested in over 350 patients in clinical trials as a monotherapy and in combination with bevacizumab for the treatment of a range of diseases or conditions, including recurrent glioblastoma, recurrent neuroblastoma and medulloblastoma, advanced malignancies, advanced unresectable pancreatic cancer, metastatic melanoma, and breast cancer metastatic to the brain. To date TPI 287 appears to have both an excellent safety pro high tolerability among patients. For more information, please visit , and connect with the Company on X and LinkedIn . Forward-Looking Statements Some of the statements in this press release are forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, Section 21E of the Securities Exchange Act of 1934 and the Private Securities Litigation Reform Act of 1995, which involve risks and uncertainties. Forward-looking statements in this release include, without limitation, statements regarding the Company's strategic evaluation, pipeline optimization plans, development and regulatory strategies for TPI 287, capital allocation strategy, plans to raise capital, expectations regarding clinical development, regulatory alignment, and value creation for shareholders. These statements relate to future events, future expectations, plans and prospects. Although CNS believes the expectations reflected in such forward-looking statements are reasonable as of the date made, expectations may prove to have been materially different from the results expressed or implied by such forward-looking statements. CNS has attempted to identify forward-looking statements by terminology including ''believes,'' ''estimates,'' ''anticipates,'' ''expects,'' ''plans,'' ''projects,'' ''intends,'' ''potential,'' ''may,'' ''could,'' ''might,'' ''will,'' ''should,'' ''approximately'' or other words that convey uncertainty of future events or outcomes to identify these forward-looking statements. These statements are only predictions and involve known and unknown risks, uncertainties and other factors, including market and other conditions and those discussed under Item 1A. "Risk Factors" in CNS's most recently filed Form 10-K filed with the Securities and Exchange Commission ("SEC") and updated from time to time in its Form 10-Q filings and in its other public filings with the SEC. Any forward-looking statements contained in this press release speak only as of its date. CNS undertakes no obligation to update any forward-looking statements contained in this press release to reflect events or circumstances occurring after its date or to reflect the occurrence of unanticipated events, except as required by law. CONTACTS: Investor Relations Contact JTC Team, LLC Jenene Thomas 908.824.0775 CNSP@jtcir.com SOURCE: CNS Pharmaceuticals, Inc. View the original press release on ACCESS Newswire