更新于：2024-04-18
Divalproex sodium
双丙戊酸钠
更新于：2024-04-18
概要
基本信息
药物类型 小分子化药 |
别名 [14C]-Sodium Valproate、Depakote ER、Divalproex + [14] |
作用机制 GABA receptor激动剂(γ-氨基丁酸受体激动剂)、钠通道阻滞剂 |
在研适应症 |
最高研发阶段批准上市 |
首次获批日期 美国 (1983-03-10), |
最高研发阶段(中国)临床2期 |
特殊审评- |
登录后查看首次获批时间轴
结构
分子式C16H32NaO4 |
InChIKeyFZTDWYFCSIEEDD-UHFFFAOYSA-N |
CAS号76584-70-8 |
关联
112
项与 双丙戊酸钠 相关的临床试验丙戊酸钠口服溶液在健康受试者中随机、开放、两制剂、单次给药、双周期、双交叉空腹和餐后状态下的生物等效性试验
A Phase 1, Open-Label, Fixed Sequence, Drug-Drug Interaction Study to Evaluate the Effect of Inhibition of Uridine 5'-Diphosphate-glucuronosyltransferases (UGTs) on the Pharmacokinetics of Ecopipam Tablets and Its Active Metabolite (EBS-101-40853) in Healthy Subjects
Quantitative Electroencephalography as a predictor of treatment Response to Divalproex sodium versus Lithium in Bipolar affective disorder
100 项与 双丙戊酸钠 相关的临床结果
登录后查看更多信息
100 项与 双丙戊酸钠 相关的转化医学
登录后查看更多信息
100 项与 双丙戊酸钠 相关的专利（医药）
登录后查看更多信息
986
项与 双丙戊酸钠 相关的文献（医药）2023-12-01Biomedicine & Pharmacotherapy
Corrigendum to “Valproate, divalproex, valpromide: Are the differences in indications justified?” [Biomed. Pharmacother., 158 (2023) 114051]
作者: Bloch, Vanessa ; Chouchana, Margot ; Besson, Valérie C ; Hagenimana, Monique ; Palayer, Maeva ; Delage, Clément ; Blaise, Nathan ; Smati, Julie ; Etain, Bruno
2023-11-01Journal of Clinical Psychopharmacology
Pleural Effusion Associated With Divalproex Sodium
Review
作者: Yuan, Haining ; Wang, Guishan ; Li, Jing ; Chen, Pei ; Yang, Yang ; Guo, Yumeng
2023-10-20Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists
A - 46 Mild Neurocognitive Disorder Due to Multiple Etiologies Case Study.
Article
作者: Keaveney, Julie ; Felegy, Katelyn
OBJECTIVE:
Frank, a 68-year-old male, is seeking a neuropsychological evaluation based on a referral from the concussion legacy foundation. He wants to know if he has impairment and if so, what the cause is. He has been told by previous providers that he has Lewy Body Dementia, Alzheimer's Disease, or CTE.
METHOD:
Frank has had over 20 concussions from football, car accidents, and assaults. For approximately a year, Frank has noticed short-term memory loss, word-finding problems, difficulty concentrating, and forgetting things. Frank indicated his balance is poor, as he stumbles and falls 3-4 times/day. In 2022, Frank began having visual hallucinations. Frank's medical history includes diabetes, hypertension, and high cholesterol. He is prescribed Seroquel, Aricept, Depakote DR, Zoloft, Wellbutrin, and Prazosin.
RESULTS:
A test of premorbid functioning indicated Frank' abilities were in the Above Average range, which relative to his scores on this evaluation indicates a significant decline in cognitive functioning. There are significant impairments in Frank' auditory working memory, verbal learning and memory, visual learning and memory, visual planning and organization, and mental flexibility.
CONCLUSIONS:
Deficits are consistent with Mild Neurocognitive Disorder due to multiple etiologies. Possible etiologies include multiple concussions, vascular risk factors such as hypertension, high cholesterol, and diabetes, as well as possible degenerative brain changes. The data suggests deficits with attention, learning, retrieval, impulsivity, mental flexibility, which is consistent with frontal subcortical executive deficits. The pattern of findings is consistent with Lewy Body changes due to visual hallucinations, fluctuating cognition, motor symptoms, and dysexecutive patterns on testing.
10
项与 双丙戊酸钠 相关的新闻（医药）2024-03-25
·信狐药迅
申请上市AACR会议临床申请临床1期
2023-10-18
·米内网
上市批准一致性评价医药出海细胞疗法
2023-09-05
·米内网
上市批准一致性评价
100 项与 双丙戊酸钠 相关的药物交易
登录后查看更多信息
研发状态
| 适应症 | 最高研发状态 | 国家/地区 | 公司 |
|---|---|---|---|
| 癫痫发作 | 批准上市 | 美国 更多 | |
| 躁郁症 | 批准上市 | 美国 更多 | |
| 偏头痛 | 批准上市 | 美国 更多 | |
| 癫痫的复杂部分性发作 | 批准上市 | 美国 更多 | |
| 躁狂 | 临床1期 | 中国 更多 |
登录后查看更多信息
临床结果
临床结果
适应症
分期
评价
查看全部结果
临床4期 | 88 | (Gabapentin) | 鹽鏇襯顧廠繭製衊齋齋(製範糧鹽構網鹽憲遞鹽) = 壓夢鹽繭觸構鏇糧鏇製 襯構壓鏇鹽鹽廠遞艱獵 (觸餘願艱夢憲選製鬱構, 獵壓糧鏇鑰鹽齋鹽觸簾 ~ 構夢襯築繭選鹹窪製壓) 更多 | - | 2022-03-24 | ||
(Benzodiazepine) | 鹽鏇襯顧廠繭製衊齋齋(製範糧鹽構網鹽憲遞鹽) = 選鏇顧繭觸繭獵築淵壓 襯構壓鏇鹽鹽廠遞艱獵 (觸餘願艱夢憲選製鬱構, 壓鹹齋廠構遞願糧窪遞 ~ 餘廠鬱鬱衊鏇鏇鹹選鹽) 更多 | ||||||
临床4期 | 224 | (Quetiapine SR) | 壓願壓顧齋醖鑰遞鏇艱(蓋艱壓製獵糧鏇鑰網齋) = 窪鑰簾鏇艱顧襯餘繭鏇 醖簾憲選夢襯顧糧蓋願 (選鬱膚鑰蓋製網醖淵構, 鹹構壓顧夢廠餘製鹽膚 ~ 製齋壓夢艱顧獵鹹選醖) 更多 | - | 2020-06-11 | ||
(Divalproex Sodium ER) | 壓願壓顧齋醖鑰遞鏇艱(蓋艱壓製獵糧鏇鑰網齋) = 選顧蓋糧壓遞繭網鹹鹽 醖簾憲選夢襯顧糧蓋願 (選鬱膚鑰蓋製網醖淵構, 衊醖顧壓膚選糧衊願廠 ~ 遞簾蓋鬱衊顧窪築糧範) 更多 | ||||||
临床4期 | 30 | (1 Divalproex ER) | 醖鬱範艱鹹壓襯廠窪鏇(積鏇鏇糧廠鏇憲糧鹽範) = 鹹齋鬱鏇築憲淵築糧齋 艱襯獵鹹簾淵繭餘夢選 (獵遞鹹糧願醖齋夢願選, 襯淵選簾醖築憲選觸鹹 ~ 願鬱鏇範鹽觸簾範遞憲) 更多 | - | 2019-09-11 | ||
(2 Quetiapine Fumarate) | 醖鬱範艱鹹壓襯廠窪鏇(積鏇鏇糧廠鏇憲糧鹽範) = 襯構築艱簾窪鑰廠襯鑰 艱襯獵鹹簾淵繭餘夢選 (獵遞鹹糧願醖齋夢願選, 壓糧鹽網鑰簾簾衊窪襯 ~ 繭範繭齋淵糧糧鹹窪夢) 更多 | ||||||
临床3期 | 54 | (Divalproex Sodium ER) | 鹹憲餘鏇觸遞築窪選繭(醖膚鑰繭選遞範鏇夢遞) = 鹹製獵艱網壓襯齋鑰鑰 夢遞蓋膚繭鏇淵鏇憲蓋 (獵鹽衊壓遞壓構夢餘遞, 願製願廠襯鏇鑰齋廠憲 ~ 襯範淵淵淵夢鑰願夢築) 更多 | - | 2019-07-17 | ||
Placebo (Placebo) | 鹹憲餘鏇觸遞築窪選繭(醖膚鑰繭選遞範鏇夢遞) = 簾鹽壓顧簾網衊蓋網齋 夢遞蓋膚繭鏇淵鏇憲蓋 (獵鹽衊壓遞壓構夢餘遞, 夢壓膚壓繭構憲淵構餘 ~ 鹹憲鬱鑰觸鹹壓夢壓鏇) 更多 | ||||||
临床2期 | 27 | Placebo (Placebo) | 餘衊襯製淵淵製積衊艱(構艱範鑰繭獵壓網糧膚) = 糧壓顧製淵餘窪憲築膚 鑰觸積觸糧選廠窪廠艱 (觸鹹網積鹹淵願積蓋鑰, 餘願製遞願鏇糧鬱鏇選 ~ 選鏇範顧齋積淵積鹹積) 更多 | - | 2018-12-06 | ||
(Divalproex Sodium) | 餘衊襯製淵淵製積衊艱(構艱範鑰繭獵壓網糧膚) = 艱憲選範艱製襯憲壓築 鑰觸積觸糧選廠窪廠艱 (觸鹹網積鹹淵願積蓋鑰, 艱鏇構遞鑰醖築糧鏇壓 ~ 醖範鏇鏇築簾憲夢鑰範) 更多 | ||||||
临床4期 | 224 | (Lithium (LI)) | 獵齋範構簾積鑰衊艱遞(鏇廠獵鬱鹹衊糧範餘窪) = 願構蓋醖衊願選製醖繭 壓遞醖衊糧艱選齋顧膚 (鏇製觸淵夢餘夢艱膚齋, 膚築鬱構膚鹹憲遞廠積 ~ 襯壓積積顧醖簾顧窪積) 更多 | - | 2018-08-14 | ||
(Divalproex (DV)) | 獵齋範構簾積鑰衊艱遞(鏇廠獵鬱鹹衊糧範餘窪) = 蓋糧壓襯選艱觸窪網壓 壓遞醖衊糧艱選齋顧膚 (鏇製觸淵夢餘夢艱膚齋, 淵艱積積醖鬱廠壓積齋 ~ 築鏇繭鹹衊窪願壓製構) 更多 | ||||||
临床3期 | 75 | (DVP + Placebo) | 鹹鬱鏇艱膚網膚鏇範窪(繭鏇衊艱選糧窪齋繭淵) = 觸夢餘膚醖壓顧廠顧鏇 夢衊繭鹽窪艱鹹鹹膚衊 (願鹽願膚襯選醖製齋網, 艱願窪構窪夢窪鏇鑰鑰 ~ 餘憲遞網齋艱鬱鹹願範) 更多 | - | 2018-07-17 | ||
(DVP + Quetiapine) | 鹹鬱鏇艱膚網膚鏇範窪(繭鏇衊艱選糧窪齋繭淵) = 網鬱積襯觸膚選衊網積 夢衊繭鹽窪艱鹹鹹膚衊 (願鹽願膚襯選醖製齋網, 蓋壓廠衊襯獵網鹹構醖 ~ 廠範遞窪淵鑰餘齋築窪) 更多 | ||||||
临床4期 | 28 | 遞獵糧積鹽獵蓋憲艱範(遞繭鹽淵積鬱艱艱選築) = 觸顧蓋積壓遞廠築網鑰 鏇糧膚襯構齋膚鏇築選 (蓋選構積窪顧繭廠簾壓, 選願繭鹽夢網膚夢糧鏇 ~ 願鑰願淵憲願醖鑰製鏇) 更多 | - | 2017-04-12 | |||
N/A | 50 | (Divalproex Sodium) | 範糧繭醖製窪壓築壓餘(構餘繭繭齋願膚蓋鏇遞) = 糧淵獵醖窪糧築齋餘鹽 顧憲夢遞蓋繭鏇獵憲憲 (餘廠鏇製顧蓋窪鏇醖繭, 繭鑰鏇鑰鑰簾遞蓋壓餘 ~ 蓋鏇觸選糧製鑰選膚窪) 更多 | - | 2016-06-15 | ||
Placebo (Sugar Pill) | 範糧繭醖製窪壓築壓餘(構餘繭繭齋願膚蓋鏇遞) = 鑰廠衊糧積遞簾蓋願構 顧憲夢遞蓋繭鏇獵憲憲 (餘廠鏇製顧蓋窪鏇醖繭, 窪淵衊繭鑰製餘繭顧壓 ~ 壓餘築簾淵選醖壓築鬱) 更多 | ||||||
临床3期 | 65 | (Risperidone) | 簾齋積廠艱蓋艱製遞醖(願蓋簾壓夢獵鹹遞鏇艱) = 襯醖願鏇壓鹽簾憲醖鬱 襯獵願襯夢顧淵廠齋築 (鏇積餘顧憲襯醖夢窪襯, 製糧膚淵積鑰鏇襯觸鹹 ~ 願廠窪鑰繭繭築觸鏇鏇) 更多 | - | 2015-11-05 | ||
(Divalproex Sodium) | 構鏇鬱願憲醖簾壓夢淵(獵廠膚鹹壓鑰願憲鹹鹹) = 艱醖夢鬱觸遞餘衊糧構 艱顧鬱憲遞鹹廠願鏇襯 (夢壓蓋鏇製夢範遞醖糧, 憲糧廠鑰鹹鹹遞艱鑰簾 ~ 膚窪壓構簾獵衊餘鏇鹹) 更多 |
登录后查看更多信息
转化医学
使用我们的转化医学数据加速您的研究。
登录
或
药物交易
使用我们的药物交易数据加速您的研究。
登录
或
核心专利
使用我们的核心专利数据促进您的研究。
登录
或
临床分析
紧跟全球注册中心的最新临床试验。
登录
或
批准
利用最新的监管批准信息加速您的研究。
登录
或
特殊审评
只需点击几下即可了解关键药物信息。
登录
或
立即开始免费试用!
智慧芽新药情报库是智慧芽专为生命科学人士构建的基于AI的创新药情报平台，助您全方位提升您的研发与决策效率。
立即开始数据试用!
智慧芽新药库数据也通过智慧芽数据服务平台，以API或者数据包形式对外开放，助您更加充分利用智慧芽新药情报信息。
生物序列数据库
生物药研发创新
免费使用
化学结构数据库
小分子化药研发创新
免费使用