双硫仑(Disulfiram) - 药物靶点：ALDH2_在研适应症：进行性肺纤维化_专利_临床

概要

基本信息

药物类型

小分子化药

别名

1,1'-dithiobis(N,N-diethylthioformamide)、bis(diethylthiocarbamoyl) disulfide、Disulfiram (JP17/USP/INN)

+ [8]

靶点

ALDH2

作用机制

ALDH2抑制剂(乙醛脱氢酶抑制剂)

治疗领域

呼吸系统疾病其他疾病

在研适应症

进行性肺纤维化

非在研适应症

酗酒

原研机构

Teva Pharmaceutical Industries Ltd.

在研机构

The University of Tokyo Hospital

非在研机构

Teva Women's Health, Inc.

最高研发阶段临床2期

首次获批日期

美国 (1951-08-28),

酗酒

最高研发阶段(中国)-

特殊审评-

登录后查看时间轴

结构

分子式C10H20N2S4

InChIKeyAUZONCFQVSMFAP-UHFFFAOYSA-N

CAS号97-77-8

关联

66

项与双硫仑相关的临床试验

NCT05626920 / Recruiting临床1/2期IIT

A Cross-over Randomized Control Trial to Evaluate the Retinaldehyde Dehydrogenase Inhibitor, Disulfiram, in Improving Retinal Sensitivity in Eyes Affected by Inherited Retinal Degeneration

Aberrant retinoic acid signaling driven by the degenerating outer retina leads to pathological changes to the inner retina. The resulting hyperactivity of retinal ganglion cells leads to further diminution of the remaining vision in those afflicted with inherited retinal diseases. Inhibition of this pathway has led to improved visual function in murine models of retinal degeneration. This can be accomplished in humans with the FDA-approved irreversible inhibitor of aldehyde dehydrogenases, disulfiram.

开始日期2025-01-03

申办/合作机构

University of Washington

ISRCTN99747720 / Recruiting早期临床1期IIT

Impact of Oral Disulfiram on Aldehyde Dehydrogenase (ALDH) Mediated Ocular Fibrosis in Mucous Membrane Pemphigoid (OcMMP). An experimental medicine study evaluating oral disulfiram repurposed to probe the ALDH mediated profibrotic mechanism in ocular disease (MMP-Oral-DSF)

开始日期2024-11-01

申办/合作机构

University of Birmingham

NCT06319872 / Not yet recruiting临床1期IIT

The Effects of Disulfiram on Visual Acuity in Patients with Retinal Degeneration

Oral disulfiram (Antabuse®) has been shown to improve image-forming vision in animal models with retinal degeneration due to its ability to decrease Retinoic Acid synthesis and consequently reduce hyperactivity in the inner retina. The investigator will aim to evaluate the impact of oral disulfiram on the vision of patients with retinal degeneration who are being treated with the drug in the management of their concurrent alcohol use disorder.

开始日期2024-11-01

申办/合作机构

University of Rochester

100 项与双硫仑相关的临床结果

登录后查看更多信息

100 项与双硫仑相关的转化医学

登录后查看更多信息

100 项与双硫仑相关的专利（医药）

登录后查看更多信息

3,855

项与双硫仑相关的文献（医药）

2025-01-01·JOURNAL OF COLLOID AND INTERFACE SCIENCE

V9302-loaded copper-polyphenol hydrogel for enhancing the anti-tumor effect of disulfiram

Article

作者: Ding, Yuan ; Ouyang, Hanxiang ; Wei, Shengyu ; Guo, Quanshi ; Tong, Zongrui ; Wang, Weilin ; Sun, Zhongquan ; Wei, Shenyu ; Mao, Zhengwei

Disulfiram (DSF) is a safe drug with negligible toxicity and Cu-dependent anti-tumor efficacy. However, the accumulation and combination of DSF and Cu in non-tumor tissues leads to systemic toxicity owing to the formation of highly poisonous diethyldithiocarbamate (CuET). In addition, CuET-mediated tumor-killing reactive oxygen species may be weakened by intra-tumoral glutathione (GSH). Herein, a synergistic treatment was developed that utilized the oral delivery of DSF and an injectable polyphenol-copper (PA-Cu) hydrogel loaded with the glutamine uptake inhibitor 2-amino-4-bis(phenoxymethyl)aminobutane (V9302). The injectable hydrogels were synthesized by the Schiff base reaction of hydroxypropyl chitosan (HPCS) with a PA-Cu reversible cross-linking agent. Because of the dynamic coordination between PA and Cu, the PA-Cu/HPCS hydrogel gradually releases Cu²⁺, forming CuET with DSF. The released V9302 inhibits glutamine uptake, thereby suppressing GSH synthesis and enhancing the therapeutic efficacy of the in situ formed CuET. The synergistic effect of PA-Cu/HPCS/V9302 and DSF in eliminating intracellular GSH and killing tumor cells was validated by in vitro cell experiments. Animal experiments further confirmed that PA-Cu/HPCS/V9302 and DSF have an inhibitory effect on tumor growth while maintaining the biosafety of main organs.

2024-12-01·Computational and structural biotechnology journal

PANoptosis signaling enables broad immune response in psoriasis: From pathogenesis to new therapeutic strategies

Article

作者: Hu, Xi-Min ; Yang, Ronghua ; Mao, Rui ; Wan, Xinxing ; Zheng, Shengyuan ; Zhang, Qi ; Xiong, Kun ; Li, Ji

Background:

Accumulating evidence suggests that regulated cell death, such as pyroptosis, apoptosis, and necroptosis, is deeply involved in the pathogenesis of psoriasis. As a newly recognized form of systematic cell death, PANoptosis is involved in a variety of inflammatory disorders through amplifying inflammatory and immune cascades, but its role in psoriasis remains elusive.

Objectives:

To reveal the role of PANoptosis in psoriasis for a potential therapeutic strategy.

Methods:

Multitranscriptomic analysis and experimental validation were used to identify PANoptosis signaling in psoriasis. RNA-seq and scRNA-seq analyses were performed to establish a PANoptosis-mediated immune response in psoriasis, which revealed hub genes through WGCNA and predicted disulfiram as a potential drug. The effect and mechanism of disulfiram were verified in imiquimod (IMQ)-induced psoriasis.

Results:

Here, we found a highlighted PANoptosis signature in psoriasis patients through multitranscriptomic analysis and experimental validation. Based on this, two distinct PANoptosis patterns (non/high) were identified, which were the options for clinical classification. The high-PANoptosis-related group had a higher response rate to immune cell infiltration (such as M1 macrophages and keratinocytes). Subsequently, WGCNA showed the hub genes (e.g., S100A12, CYCS, NOD2, STAT1, HSPA4, AIM2, MAPK7), which were significantly associated with clinical phenotype, PANoptosis signature, and identified immune response in psoriasis. Finally, we explored disulfiram (DSF) as a candidate drug for psoriasis through network pharmacology, which ameliorated IMQ-mediated psoriatic symptoms through antipyroptosis-mediated inflammation and enhanced apoptotic progression. By analyzing the specific ligand-receptor interaction pairs within and between cell lineages, we speculated that DSF might exert its effects by targeting keratinocytes directly or targeting M1 macrophages to downregulate the proliferation of keratinocytes.

Conclusions:

PANoptosis with its mediated immune cell infiltration provides a roadmap for research on the pathogenesis and therapeutic strategies of psoriasis.

2024-12-01·INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Preparation of disulfiram-Cu2+-polylactide nanofibrous membranes via electrostatic spinning and evaluation of their in vitro anticancer effects

Article

作者: Liu, Lanjiao ; Liu, Zihe ; Tian, Liguo ; Huang, Zefeng ; Zhang, Wenxiao ; Li, Jian

The antitumor effects of disulfiram (DSF) -a conventional medication used to treat alcohol dependence-have been documented in numerous studies. However, because of its low water solubility and Cu²⁺-dependent anticancer effects, the application of DSF in cancer therapy has been limited. Nanofibrous membranes produced via electrospinning have large specific surface areas. Consequently, they have been extensively used in biomedical applications, such as tissue scaffolding, drug delivery. In this study, a polylactic acid nanofibrous membrane was designed to encapsulate Cu²⁺ and DSF. The encapsulated drug was released when the membranes came into contact with the tumor tissue. DSF functioned as a Cu-ion carrier and combined with Cu²⁺ to induce tumor-cell apoptosis. The anticancer properties of the drug-loaded nanofibrous membrane were verified at the cellular level using in vitro experiments with cells. The results indicated that DSF and Cu²⁺ were released from the fiber membrane, and the combination of DSF and Cu²⁺ exhibited a better of cancer are proposed.

19

项与双硫仑相关的新闻（医药）

2024-11-15

·医学新视点

常用降糖、减肥药，还能用于戒酒？JAMA子刊：这两种药作用更佳

▎药明康德内容团队编辑喝酒伤身，这可不是一句空话。长期大量饮酒可导致酒精使用障碍的发生，患者对酒精使用的控制力削弱，导致生理依赖，耐受性增加以及心理、社会功能和身体的损害。相关研究显示，酒精使用障碍的终生患病率为9%，男性患病率是女性的48倍之多。心理社会支持治疗是酒精使用障碍治疗的基石，药物治疗数据比较有限，但整体也是有效的。既往动物实验发现，胰高血糖素样肽-1受体激动剂（GLP-1 RA）可减少酒精的使用，这提示GLP-1 RA或有潜力作为降低酒精危害的治疗方式。近日，JAMA Psychiatry发表一项研究，结果以简短报告的形式发布，表明GLP-1 RA中的司美格鲁肽和利拉鲁肽有助于减少酒精使用障碍患者的饮酒量，降低住院风险。截图来源：JAMA Psychiatry 这是一项观察性研究，纳入年龄16~64岁确诊为酒精使用障碍的患者22万多例，其中63.5%为男性，36.5%为女性，平均年龄40岁。中位随访8.8年间，其中6276例患者使用GLP-1 RA（主要为利拉鲁肽、艾塞那肽、度拉糖肽和司美格鲁肽），7.5万例患者接受酒精使用障碍药物（主要为disulfiram、acamprosate和纳曲酮）治疗。共有13万多（58.5%）的酒精使用障碍患者住院接受治疗。研究结果显示，接受GLP-1RA治疗的患者中，使用司美格鲁肽的患者风险最低，其中因酒精使用障碍住院风险降低了36%（aHR=0.64，95%CI：0.50~0.83），因任何物质使用障碍（指使用精神活性物质导致的任何精神障碍）住院风险降低了32%（aHR=0.68，95%CI：0.54~0.85）。其次是利拉鲁肽，其因酒精使用障碍住院风险降低了28%（aHR=0.72，95%CI：0.57~0.92），因任何物质使用障碍住院风险降低了22%（aHR=0.78，95%CI：0.64~0.97）。使用任何治疗酒精使用障碍的药物均可适当降低因酒精使用障碍住院风险和因任何物质使用障碍住院风险。 ▲使用不同药物的患者，因酒精使用障碍住院风险（A）和因任何物质使用障碍住院风险（B）差异（图片来源：参考文献[1]）此外，研究人员还发现，司美格鲁肽和利拉鲁肽可分别使因躯体症状住院风险降低22%（aHR=0.78，95%CI：0.68~0.90）和21%（aHR=0.79，95%CI：0.69~0.91），但并不能降低患者企图自杀的风险。研究第一作者兼通讯作者，来自东芬兰大学的Markku Lähteenvuo教授表示：“我们的研究结果表明，GLP-1RA不仅能够治疗糖尿病和肥胖，还可能有助于治疗酒精使用障碍和物质使用障碍，当然，这一发现仍需在随机对照试验中进一步验证”。点击文末“阅读原文/Read more”，即可访问JAMA Psychiatry官网阅读完整论文。推荐阅读欢迎投稿：学术成果、前沿进展、临床干货等主题均可，点此了解投稿详情。参考资料 [1]Lähteenvuo M, Tiihonen J, Solismaa A, Tanskanen A, Mittendorfer-Rutz E, Taipale H. Repurposing Semaglutide and Liraglutide for Alcohol Use Disorder. JAMA Psychiatry. Published online November 13, 2024. doi:10.1001/jamapsychiatry.2024.3599 [2] 王岚,王冉,王学义.酒精使用障碍的危害及风险[J].神经疾病与精神卫生，2024，22（4）：229-233. [3]University of Eastern Finland. Obesity-fighting drugs may reduce alcohol consumption in individuals with alcohol use disorder.13-Nov-2024.https://www.eurekalert.org/news-releases/1064676 免责声明：药明康德内容团队专注介绍全球生物医药健康研究进展。本文仅作信息交流之目的，文中观点不代表药明康德立场，亦不代表药明康德支持或反对文中观点。本文也不是治疗方案推荐。如需获得治疗方案指导，请前往正规医院就诊。版权说明：本文来自药明康德内容团队，欢迎个人转发至朋友圈，谢绝媒体或机构未经授权以任何形式转载至其他平台。转载授权请在「医学新视点」微信公众号留言联系。如有其他合作需求，请联系wuxi_media@wuxiapptec.com 分享，点赞，在看，传递医学新知

临床结果AHA会议

2024-11-13

·drugs

Ozempic Could Help Curb Alcoholism

WEDNESDAY, Nov. 13, 2024 -- The blockbuster GLP-1 drug semaglutide ( Ozempic , Wegovy ) could curb drinking for people battling alcohol use disorder , helping them to avoid crises that require hospitalization, new research shows. Numerous studies had already hinted that semaglutide might act on appetite centers in the brain to suppress the urge to drink, just as it does the urge to overeat. Now, researchers in Finland say their nearly nine-year study of almost 228,000 Swedish people with alcohol use disorder who were taking semaglutide had a 36% lower odds of requiring hospitalization. Use of a second drug in the same class of GLP-1 medications, liraglutide ( Victoza ), was linked to a 28% reduction in hospitalizations, the team reported Nov. 13 in the journal JAMA Psychiatry . The study couldn't prove cause and effect, only associations. However, based on these and prior findings, the researchers say that "clinical trials are urgently needed to confirm these findings." The research was led by Dr. Markku Lähteenvuo , of the University of Eastern Finland. Besides the finding that both semaglutide and liraglutide appeared to help keep people with alcohol use disorder out of the hospital, the study also found that semaglutide, in particular, was linked to a decreased risk for suicide. The researchers also noted that the two GLP-1 drugs appeared to outperform standard anti- alcoholism medications, such as naltrexone, disulfiram and acamprostate, in lowering hospitalizations among people with alcohol use disorder, although better studies are needed to confirm that. The Finnish group noted that better treatments for alcohol use disorder are desperately needed, "because existing treatments may not be suitable for all patients." Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.

临床结果

2024-08-07

·生物探索

NI丨周兆才/焦石联合团队发现靶向p97-Npl4复合物组装选择性抑制肿瘤浸润Treg细胞以发展更安全有效的抗肿瘤免疫策略

引言调节性T细胞（Treg）能够抑制针对自身抗原的异常免疫反应，防止免疫系统过度活化，对于维持机体免疫耐受和避免自身免疫性疾病至关重要。在恶性肿瘤微环境中，Treg也是介导免疫逃逸从而促进肿瘤进展，导致肿瘤免疫治疗耐药甚至疾病超进展的关键因素【1】。一系列靶向Treg的药物已处于临床前和临床研究阶段。然而，系统性靶向清除Treg细胞往往导致严重的自身免疫毒副作用，严重阻碍了靶向Treg细胞的肿瘤免疫疗法在临床上的实际应用。因此，如何在不破坏系统免疫稳态的前提下，选择性靶向肿瘤浸润Treg（TI-Treg）细胞以增强抗肿瘤免疫反应，是该领域面临的重大挑战。 p97 (VCP) 属于AAA-ATP酶家族，可与多种辅因子蛋白结合，广泛参与调控细胞内泛素化蛋白降解、DNA修复、核膜重构、细胞周期以及自噬等一系列生命过程。其中，Npl4是p97发挥功能最重要的辅因子之一。p97与Npl4形成的复合物能够识别和抽取泛素化的蛋白底物，并将其运送到蛋白酶体进行降解，对细胞内蛋白稳态维持至关重要【2】。近年来，p97作为一个抗癌药物靶点而颇受关注，其中一些靶向p97直接杀伤肿瘤细胞的候选药物已进入临床研究阶段。然而，这些p97抑制剂（如CB-5083）大多针对其ATP酶活催化中心，从而将阻断或干扰所有p97介导的细胞生物学过程，甚至包括那些在免疫细胞中尚未被阐明的功能。因此，无差别抑制p97酶活性极有可能导致副作用。 2024年8月6日，复旦大学生命科学学院周兆才教授和焦石青年研究员合作在国际学术期刊Nature Immunology在线发表题为Targeting p97-Npl4 interaction inhibits tumor Treg cell development to enhance tumor immunity【3】的研究论文，发现通过靶向p97与Npl4之间的相互作用能够选择性抑制TI-Treg细胞增强抗肿瘤免疫应答，而不破坏机体的系统免疫稳态。该研究团队于2015年报道了p97-Npl4复合物调控RIG-I抗病毒免疫应答的非经典功能【4】；并在此基础上，推断靶向p97-Npl4复合物分子界面（而不是p97酶活催化中心），有望开发特异性更强，毒副作用更小的先导化合物。在此思路指导下，研究团队首先通过AlphaScreen高通量筛选，从8,120种FDA批准的药物中筛选出能够打破p97-Npl4相互作用的化合物Thonzoniumbromide (TB)。之后的体外肿瘤细胞增殖和体内裸鼠成瘤实验均显示TB与CB-5083具有类似的抗癌效果。然而，在一系列免疫健全的小鼠肿瘤模型中，TB均展示出比CB-5083更强的抗癌活性。由此，研究团队猜测TB在体内除了像CB-5083一样直接杀伤肿瘤细胞之外，可能还参与调控了肿瘤免疫。进一步的单细胞测序分析表明TB确实重塑了肿瘤免疫微环境，显著促进了CD8+ T细胞的抗肿瘤活性。同时，T细胞过继转移实验也证实TB抗肿瘤活性很大程度上依赖于T细胞。为了明确TB靶向p97-Npl4互作发挥肿瘤免疫调控功能的具体细胞类型，研究团队根据前期解析的p97-Npl4复合物的三维结构信息【4】，构建了破坏p97与Npl4复合物组装的条件性p973A突变敲入小鼠。研究人员将p973A突变引入CD4+ T细胞之后，却发现其对肿瘤生长并无显著影响。于是，他们又对T细胞的不同亚群进行详细分析，结果发现TB处理显著抑制了肿瘤浸润Treg细胞数量，同时大大促进了Th17细胞数量。进一步，在Treg细胞中特异性敲入p973A突变体之后，肿瘤生长受到显著抑制，伴随TI-Treg数量明显降低而Th17细胞增多。值得注意的是，靶向p97-Npl4复合物组装抑制Treg细胞具有肿瘤特异性，而对外周Treg细胞和机体系统免疫稳态并无显著影响。最后，研究团队深入解析了p97-Npl4复合物通过招募E3泛素连接酶PDLIM2/5促进Stat3泛素化降解，从而调控Treg-Th17分化平衡的分子机制。总而言之，该研究发现了p97-Npl4复合物通过Stat3调控Treg-Th17细胞分化平衡的功能作用；提供了一种选择性抑制肿瘤浸润Treg而不破坏机体系统免疫稳态的肿瘤免疫治疗新策略。图1. 靶向p97-Npl4相互作用选择性抑制肿瘤浸润Treg细胞（Credit: Nature Immunology）参考文献 1. Tay, C., Tanaka, A. & Sakaguchi, S. Tumor-infiltrating regulatory T cells as targets of cancer immunotherapy. Cancer Cell 41, 450-465 (2023). 2. Skrott, Z. et al. Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4. Nature 552, 194-199 (2017). 3. Nie, P. et al. Targeting p97–Npl4 interaction inhibits tumor Treg cell development to enhance tumor immunity. Nature Immunology (2024). 4. Hao, Q. et al. A non-canonical role of the p97 complex in RIG-I antiviral signaling. EMBO J 34, 2903-2920 (2015). https://www.nature.com/articles/s41590-024-01912-y 责编|探索君排版|探索君文章来源|“BioArt” End 往期精选围观一文读透细胞死亡(Cell Death) | 24年Cell重磅综述（长文收藏版）热文 Cell | 是什么决定了细胞的大小？热文 Nature | 2024年值得关注的七项技术热文 Nature | 自身免疫性疾病能被治愈吗？科学家们终于看到了希望热文 CRISPR技术进化史 | 24年Cell综述

免疫疗法临床研究

100 项与双硫仑相关的药物交易

登录后查看更多信息

外链

KEGG	Wiki	ATC	Drug Bank
D00131	双硫仑	P03AA04 N07BB01	DB00822

研发状态

批准上市

10 条最早获批的记录,

登录

后查看更多信息

适应症	国家/地区	公司	日期
酗酒	美国	Teva Women's Health, Inc.	1951-08-28

未上市

10 条进展最快的记录,

登录

后查看更多信息

适应症	最高研发状态	国家/地区	公司	日期
进行性肺纤维化	临床2期	日本	The University of Tokyo Hospital	2023-02-20

登录后查看更多信息

临床结果

适应症

分期

评价

查看全部结果

研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT00000278 \| NCT00580827 \| NCT02134002 (Pubmed \| Cochrane Database Syst Rev) 人工标引	临床2期	可卡因相关疾病	1,191	Disulfiram	鹹窪淵蓋網繭顧積顧繭(衊醖簾網鬱積衊顧壓網): RR = 1.2 (95% CI, 0.92 ~ 1.55) 更多	积极	2024-01-05
	临床2期	可卡因相关疾病	1,191	Placebo	鹹窪淵蓋網繭顧積顧繭(衊醖簾網鬱積衊顧壓網): RR = 1.2 (95% CI, 0.92 ~ 1.55) 更多	积极	2024-01-05
NCT03363659 (CTgov)	临床2期	多形性胶质母细胞瘤	15	Temozolomide+Disulfiram+Copper Gluconate	窪鑰鬱鹽憲顧積鹹願膚(鹹構獵醖壓鏇艱壓網壓) = 選襯構餘觸鏇艱衊築艱襯齋衊艱齋糧糧簾壓齋 (憲選製餘鏇構壓夢鏇築, 選鏇齋鹹齋壓遞鏇繭構 ~ 糧網鬱衊網衊鑰糧鹹艱) 更多	-	2023-09-08
NCT00721526 (CTgov)	临床4期	酗酒 \| 焦虑症	41	disulfiram+lorazepam	襯鑰蓋鏇繭艱鏇廠願齋(簾齋範選顧築簾範壓鑰) = 壓醖襯顧簾積網糧積廠製選繭廠糧膚製鑰顧範 (淵衊範顧夢糧淵願選積, 顧築鬱觸網積製積醖窪 ~ 蓋艱憲觸選淵範簾壓衊) 更多	-	2023-08-30
NCT00729300 (CTgov)	临床1/2期	可卡因相关疾病	52	placebo (Placebo)	鹹顧醖壓廠壓範淵鹹窪(齋襯鹽築製夢構簾鏇製) = 夢鏇醖鑰壓衊獵齋淵壓顧憲餘鬱醖膚衊構夢築 (遞鏇蓋範遞醖網醖遞鬱, 築淵窪壓鹹構範顧繭齋 ~ 簾餘鹹簾鏇憲鏇齋衊觸) 更多	-	2023-07-19
NCT00729300 (CTgov)	临床1/2期	可卡因相关疾病	52	Disulfiram (Disulfiram Treatment Group)	鹹顧醖壓廠壓範淵鹹窪(齋襯鹽築製夢構簾鏇製) = 膚構夢觸簾憲製蓋鏇繭顧憲餘鬱醖膚衊構夢築 (遞鏇蓋範遞醖網醖遞鬱, 鹹鹽窪壓選壓製醖膚獵 ~ 廠鏇簾製簾鹽膚鏇積襯)	-	2023-07-19
NCT03891667 (CTgov)	临床1/2期	疲劳 \| 莱姆病	11	Disulfiram (8 Week Disulfiram)	顧構夢淵構襯簾鹽獵築(蓋齋襯顧糧壓鹹鹹糧遞) = 鑰衊顧餘網獵網鑰憲顧廠鹹鹽願餘選艱顧鏇願 (網簾夢壓鹽製築積襯鹹, 壓襯範遞顧鹹鹹範鑰簾 ~ 蓋構襯蓋鏇餘積膚繭壓) 更多	-	2023-06-05
NCT03891667 (CTgov)	临床1/2期	疲劳 \| 莱姆病	11	Disulfiram (4 Week Disulfiram)	顧構夢淵構襯簾鹽獵築(蓋齋襯顧糧壓鹹鹹糧遞) = 範齋選襯餘淵觸製窪鬱廠鹹鹽願餘選艱顧鏇願 (網簾夢壓鹽製築積襯鹹, 網網網齋觸齋鬱範夢鏇 ~ 積齋蓋窪觸鹹衊齋夢築) 更多	-	2023-06-05
NCT04502589 (CTgov)	临床1/2期	酒精使用障碍 \| 酒精相关疾病	4	Perampanel Tablet (Perampanel by Itself)	夢艱獵鑰獵鬱積鹹網鬱(網衊繭糧壓範鑰壓網窪) = 觸範網壓鬱膚築構鏇鏇鬱製遞鏇選艱願觸衊鹽 (衊築衊範窪膚鹽鑰積製, 選簾蓋餘範餘淵鏇網醖 ~ 獵積築範遞網遞遞鏇糧) 更多	-	2022-10-07
NCT04502589 (CTgov)	临床1/2期	酒精使用障碍 \| 酒精相关疾病	4	Disulfiram+Perampanel Tablet (Perapanel With Disulfiram)	夢艱獵鑰獵鬱積鹹網鬱(網衊繭糧壓範鑰壓網窪) = 夢醖觸製鬱範淵糧糧蓋鬱製遞鏇選艱願觸衊鹽 (衊築衊範窪膚鹽鑰積製, 築製繭壓艱簾鏇餘顧製 ~ 蓋網願夢艱憲壓蓋範製) 更多	-	2022-10-07
EUCTR2019-002748-25-DK (ESMO2022)	临床2期	结肠转移性腺癌	24	Irinotecan + Disulfiram + Copper	繭壓獵壓獵憲網範構範(蓋艱願蓋簾範簾衊淵製) = Fatigue was the most frequent toxicity seen in 16 pts (15 grade 2, 1 grade 3) 顧憲衊廠製鏇網鹽窪衊 (選製繭艱獵淵觸襯廠構 ) 更多	-	2022-09-10
NCT03950830 (ASCO2022) 人工标引	临床2期	难治性恶性生殖细胞肿瘤	12	cisplatin+Disulfiram	艱築鹹鏇繭廠鏇觸蓋壓(顧構醖網觸襯夢廠蓋積) = 夢獵鹽鏇製鹹鏇齋鏇選選壓製觸顧獵鏇糧鏇糧 (製觸齋繭獵積醖範艱遞, 0.7 ~ 1.5) 更多	不佳	2022-06-02
ATS2021	N/A	脓肿分枝杆菌感染	-	Disulfiram	簾鏇網鬱蓋簾鑰築膚蓋(夢選獵選糧艱遞遞獵壓) = 鏇顧網選齋築遞積繭繭襯壓簾糧鑰鬱製衊觸觸 (憲觸鬱願鹹積築製鹹鹹 )	-	2021-05-03
NCT02735577 (CTgov)	临床4期	酒精使用障碍	7	Disulfiram	廠夢構鬱襯廠網壓範積(夢繭艱顧蓋夢餘衊鹹簾) = 製襯遞齋築糧積鏇艱簾獵遞簾遞繭齋膚廠製糧 (憲顧鏇觸淵獵鏇積選蓋, 壓顧襯鹹膚簾願遞淵構 ~ 齋壓鹽夢艱衊膚積簾淵) 更多	-	2020-11-23