预约演示
更新于：2026-10-23
Disulfiram
双硫仑
更新于：2026-10-23
概要
基本信息
权益机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)- |
特殊审评- |
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结构/序列
分子式C10H20N2S4 |
InChIKeyAUZONCFQVSMFAP-UHFFFAOYSA-N |
CAS号97-77-8 |
关联
62
项与 双硫仑 相关的临床试验NCT07843537
MINTER Trial: Metal Intervention aNd ThErapy With Radiotherapy In Thoracic Cancer Using Copper Donor Therapy: A Phase 2, Open-Label Study
This study is being done to test whether adding two drugs-disulfiram and copper gluconate-to radiation therapy can help overcome this resistance and improve treatment outcomes. When disulfiram is combined with copper, it forms a substance that may increase stress within cancer cells and lead to a specific type of cancer cell death knowns as "cuproptosis".
开始日期2027-03-01 |
NCT01777919
A PHASE II CLINICAL TRIAL FOR THE EVALUATION OF THE EFFICACY OF DISULFIRAM/COPPER COMBINATION AS AN ADJUVANT AND CONCURRENT CHEMOTHERAPY IN THE TREATMENT OF NEWLY DIAGNOSED GLIOBLASTOMA MULTIFORM
Glioblastoma multiform (GBM) is the most common malignant primary brain tumor in adults. Despite maximal treatment tumor relapse occurs regularly accompanied by unfavourable prognosis. Among other reasons, it is believed that this could be in part due to the existence of the so-called tumor stem cells (TSCs), a cellular subfraction within GBM which escape therapy by being highly resistant to irradiation and chemotherapy and thus constituting the source of tumor recurrence.
GBM, like many other cancers, show a sub-population of aldehyde dehydrogenase (ALDH) overexpressing TSCs. More specifically, ALDH1A1, a cytoplasmatic isoform of ALDH, proved to be a novel stem cell marker in human GBM. In addition, ALDH1A1 has been shown to be a mediator for resistance of GBM to temozolomide (TMZ) and a reliable predictor of clinical outcome; prognosis of patients with a high level of ALDH1A1 expression was poor compared with that of patients with low levels. Consequently, ALDH1A1 may serve as a potential target to improve treatment of human GBM through inhibition of the enzyme.
Disulfiram (DSF) has been used for more than sixty years in the treatment of chronic alcoholism because of the unpleasant symptoms it provokes after ethanol intake. The underlying mechanism is believed to be the accumulation of acetaldehyde in the blood, due to inhibition of the liver ALDHs. Actually, DSF is a strong inhibitor of ALDH1A1 and relatively non-toxic at therapeutic (for chronic alcoholism) doses that can penetrate the blood-brain barrier. In addition, DSF has been shown to be cytotoxic on GBM stem-like cells, inhibiting the growth of TMZ resistant GBM cells and blocking self-renewal by
100% , while it has been identified as an inhibitor of human GBM stem cells in high-throughput chemical screens. Interestingly, a number of these actions were copper-dependent.
In the current Phase II clinical trial, DSF/copper combination will be tested as an adjunctive and concurrent chemotherapy in the treatment of newly diagnosed GBM. According to our hypothesis, initiation of DSF chemotherapy after the resection of the tumor and before the introduction of the standard radio-chemotherapy will inhibit ALDH1A1 of GBM TSCs making them more susceptible to radio-chemotherapy and possibly reducing the recurrence rate of GBM. On the other hand, the addition of copper will probably enhance the cytotoxic effects of DSF possibly through augmentation of its pro-apoptotic and proteasomal inhibitory actions.
GBM, like many other cancers, show a sub-population of aldehyde dehydrogenase (ALDH) overexpressing TSCs. More specifically, ALDH1A1, a cytoplasmatic isoform of ALDH, proved to be a novel stem cell marker in human GBM. In addition, ALDH1A1 has been shown to be a mediator for resistance of GBM to temozolomide (TMZ) and a reliable predictor of clinical outcome; prognosis of patients with a high level of ALDH1A1 expression was poor compared with that of patients with low levels. Consequently, ALDH1A1 may serve as a potential target to improve treatment of human GBM through inhibition of the enzyme.
Disulfiram (DSF) has been used for more than sixty years in the treatment of chronic alcoholism because of the unpleasant symptoms it provokes after ethanol intake. The underlying mechanism is believed to be the accumulation of acetaldehyde in the blood, due to inhibition of the liver ALDHs. Actually, DSF is a strong inhibitor of ALDH1A1 and relatively non-toxic at therapeutic (for chronic alcoholism) doses that can penetrate the blood-brain barrier. In addition, DSF has been shown to be cytotoxic on GBM stem-like cells, inhibiting the growth of TMZ resistant GBM cells and blocking self-renewal by
100% , while it has been identified as an inhibitor of human GBM stem cells in high-throughput chemical screens. Interestingly, a number of these actions were copper-dependent.
In the current Phase II clinical trial, DSF/copper combination will be tested as an adjunctive and concurrent chemotherapy in the treatment of newly diagnosed GBM. According to our hypothesis, initiation of DSF chemotherapy after the resection of the tumor and before the introduction of the standard radio-chemotherapy will inhibit ALDH1A1 of GBM TSCs making them more susceptible to radio-chemotherapy and possibly reducing the recurrence rate of GBM. On the other hand, the addition of copper will probably enhance the cytotoxic effects of DSF possibly through augmentation of its pro-apoptotic and proteasomal inhibitory actions.
开始日期2027-01-01 |
申办/合作机构  Universität Ulm [+2] |
NCT07719127
A Window-of-Opportunity Study of Disulfiram to Reduce Myeloid Immunosuppression and Steroid Dependence in Resectable High-Grade Glioma
This research study is for participants with glioblastoma. It can cause a tumor immunosuppression which helps myeloid cells that can stop T-cell function. Disulfiram is a drug that has been used in treating other disorders, but this study will examine if disulfiram can help make the tumor environment less immunosuppressive and reduce brain swelling when taken before surgery.
开始日期2026-10-01 |
100 项与 双硫仑 相关的临床结果
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100 项与 双硫仑 相关的转化医学
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100 项与 双硫仑 相关的专利（医药）
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5,101
项与 双硫仑 相关的文献（医药）2026-12-31·ANNALS OF MEDICINE
The molecular mechanism of cuproptosis and research progress in pancreatic diseases
Review
作者: Chen, Huijun ; Li, Shengqiang ; Lv, Zhen ; Zhang, Peng ; Wang, Qizhi ; Li, Yingxiao ; Zhao, Chuanliang
PURPOSE:
Cuproptosis has been proven to be a novel mode of cell death, distinct from other types of cell death such as necrosis, ferroptosis, pyroptosis, and apoptosis. This study aims to systematically review the molecular mechanisms of cuproptosis in recent years and its research progress in pancreatic diseases.
METHODS:
By searching PubMed and Web of Science databases, 113 key literatures were included for thematic analysis, covering the molecular mechanism of cuproptosis and its role in the occurrence and development of pancreatic cancer, acute and chronic pancreatitis, diabetes, pancreatic cyst, pancreatic injury and pancreatic neuroendocrine tumor.
RESULTS:
Cuproptosis refers to the accumulation of copper ions in cells, which leads to instability of ferritin and aggregation of acylated proteins, resulting in oxidative stress-related cell death. Recent studies have shown that cuproptosis plays an important role in the occurrence and development of various pancreatic diseases, such as pancreatic cancer, acute and chronic pancreatitis, diabetes, pancreatic cysts, pancreatic injuries and pancreatic neuroendocrine tumor. The inducers of cuproptosis, such as disulfiram, chloroquinolones, and perilla phenols, alleviate pancreatic cancer by promoting cell cuproptosis. Copper chelators such as tetraethylenepentamine and tetrathiomolybdate promote the recovery of pancreatic injury by inhibiting cell cuproptosis.
CONCLUSIONS:
Cuproptosis plays a crucial role in the pathogenesis of pancreatic diseases. Further research on the cuproptosis pathway may become a potential target for the treatment of pancreatic diseases.
2026-12-01·MOLECULAR BIOLOGY REPORTS
MicroRNA-223-3p/NLRP3 axis attenuates LPS-induced sepsis-like myocardial dysfunction by suppressing cardiomyocyte pyroptosis
Article
作者: Cheng, Zheng ; Aji, Nurbiya ; Wang, Tingting ; Zhang, Bixue ; Zhou, Xintao ; Wu, Yuhong ; Sun, Yuanliang ; Xu, Qianqian ; Li, Xin ; Zhao, Kaikai
BACKGROUND:
Sepsis-induced cardiomyopathy (SIC), a life-threatening complication of sepsis that is characterized by myocardial inflammation and cardiomyocyte death, remains a critical clinical challenge. MicroRNA (miRNA) is involved in the development of SIC. However, the roles and underlying mechanisms of miR-223-3p and pyroptosis in SIC remain unclear.
METHODS AND RESULTS:
In vitro and in vivo LPS-induced sepsis-like myocardial dysfunction (SLMD) models were established in order to partially represent SIC. Assessments via CCK-8 assay, flow cytometry, qRT-PCR, Western blotting, immunofluorescence, histological staining, and transmission electron microscopy revealed that miR-223-3p overexpression significantly increased cardiomyocyte viability, reduced the marker levels of pyroptosis, improved cardiac function, and alleviated myocardial injury. In contrast, miR-223 knockout (KO) decreased cardiomyocyte viability, increased the marker levels of pyroptosis, aggravated heart failure, and induced cardiac damage. Mechanistically, miR-223-3p suppressed LPS-induced NLRP3 inflammasome activation and inhibited the LPS-induced interaction between caspase-1 and gasdermin D. Notably, upon treatment with NLRP3 siRNA or a GSDMD-targeting pyroptosis inhibitor disulfiram, miR-223-3p failed to exert additional protective effects against SLMD.
CONCLUSIONS:
These findings demonstrate that miR-223-3p attenuates LPS-Induced SLMD by inhibiting the NLRP3 inflammasome and cardiomyocyte pyroptosis.
2026-11-01·DRUG AND ALCOHOL DEPENDENCE
Nationwide trends of six medications for alcohol use disorder prescriptions post-discharge in patients hospitalized with alcohol-associated liver disease between 2015 and 2024
Article
作者: Yeo, Yee Hui ; Zhang, Wei ; Ting, Peng-Sheng ; Chan, Shu-Yen ; Yang, Hsien Yao
INTRODUCTION:
Alcohol associated liver disease (ALD) carries a high risk of hospitalization and recidivism, yet post-discharge medications for alcohol use disorder (MAUD) are not universally prescribed. MAUD prescriptions have been associated with reduced recidivism and hepatic decompensation. However, national data on prescribing patterns is limited. We examined ten-year trends in six MAUD prescriptions after hospitalization for ALD.
METHODS:
We identified 150,241 US adults hospitalized with ALD between 2015 and 2024 using electronic health records from TriNetX. Outcomes included annual prevalence, incidence rate, and incidence proportion of post-discharge MAUD prescriptions. FDA-approved agents included disulfiram, acamprosate, and naltrexone; off-label agents included topiramate, baclofen, and gabapentin. Trends were assessed using Joinpoint regression with annual percentage change (APC) and average annual percentage change (AAPC). Subgroup analyses were stratified by cirrhosis status and sex.
RESULTS:
FDA-approved MAUD had consistently lower prescription rates than off-label agents over the past decade. From 2015-2024, disulfiram was the only FDA-approved agent with a declining trend, while acamprosate (AAPC 20.35%) and naltrexone (AAPC 17.83%) demonstrated significant increases for new prescriptions. By 2024, the prevalence of FDA-approved and off-label MAUD prescriptions were 17.98% and 41.96%, respectively. Patients with cirrhosis had lower prescribing rates but exhibited greater relative increases in FDA-approved MAUD prescriptions. Women were more likely to receive off-label prescriptions, though both sexes showed similar upward trends.
CONCLUSION:
Post-discharge MAUD prescribing for ALD has risen significantly, but less than 20% of patients receive FDA-approved MAUD. Expanding access to evidence-based medications is critical to improve outcomes in this high-risk population.
82
项与 双硫仑 相关的新闻（医药）2026-10-15
期刊：Journal of Hematology & Oncology
影响因子：47.8
客户单位：武汉大学
文章作者：武汉大学医学研究院邓晓颐、博士邓在冬、华中科技大学协和肿瘤科朱斌为共同第一作者。武汉大学中南医院教授陈宁南、教授俞雁寻，合武汉大学中南医院肿瘤科主任、教授医生刘羽为本文共同通讯作者。
研究背景
肿瘤代谢应激与免疫原性细胞死亡的交汇
肿瘤免疫治疗的核心挑战之一，是如何将免疫学上“冷”的肿瘤转化为“热”的肿瘤。免疫原性细胞死亡（ICD）是一种特殊的细胞死亡形式，能够释放损伤相关分子模式（DAMPs），激活树突状细胞，促进抗原呈递，最终激活 CD8+ T 细胞介导的抗肿瘤免疫。然而，肿瘤细胞如何逃逸 ICD，以及代谢应激如何调控这一过程，仍不清楚。
铁死亡和铜死亡是近年来备受关注的两种新型细胞死亡方式。铁死亡以脂质过氧化和铁依赖性活性氧（ROS）积累为特征；铜死亡则依赖于铜离子诱导的线粒体应激和蛋白质毒性。两者都与 ROS 稳态密切相关。谷胱甘肽（GSH）是细胞内最主要的抗氧化分子，而谷胱甘肽二硫还原酶（GSR）是维持 GSH 还原状态的关键酶。GSH/GSR 轴在肿瘤耐药和代谢应激中扮演核心角色，但它是否以及如何调控铁死亡和铜死亡的免疫原性，尚属未知。
武汉大学中南医院教授陈宁南、教授俞雁寻联合武汉大学中南医院肿瘤科主任、教授医生刘羽团队，本研究首次系统揭示了GSR作为铁死亡和铜死亡免疫原性的核心调控节点，阐明了GSR缺失通过放大ROS积累、激活cGAS-STING通路，最终增强抗肿瘤免疫的完整分子机制。
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该研究以《Glutathione reductase deficiency potentiates the immunogenicity of ferroptosis and cuproptosis via amplified reactive oxygen species accumulation and cGAS-STING pathway activation》为题，于北京时间2026年9月1日发表于《血液学与肿瘤学杂志》。该研究不仅深化了人类对代谢应激如何调控抗肿瘤免疫的理解，也为开发代谢干预联合免疫治疗的新策略提供了全新思路。
核心实验发现与机制解析
01. 现象关联
GSR 是铁死亡和铜死亡免疫原性的关键调控因子
本研究首先通过全基因组 CRISPR 筛选，在多种肿瘤细胞系中鉴定出 GSR 是铁死亡和铜死亡敏感性的关键调控基因。GSR 缺失显著增强了肿瘤细胞对铁死亡诱导剂（如 Erastin、RSL3）和铜死亡诱导剂（如 Elesclomol、Disulfiram）的敏感性。
值得注意的是，GSR 缺失不仅促进细胞死亡，还显著增强了死亡的免疫原性——表现为细胞表面钙网蛋白（CRT）暴露增加、HMGB1 释放增多、ATP 分泌升高，这些都是 ICD 的经典标志。
图1 GSR 缺失增强铁死亡和铜死亡中的免疫激活
02. 功能确证
GSR 缺失通过 ROS 放大激活 cGAS-STING 通路
为了验证 GSR 缺失的免疫原性效应，本研究在多种肿瘤模型中进行了功能实验。
在体外
GSR 敲除或抑制剂处理导致细胞内 ROS 水平显著升高，伴随脂质过氧化产物 4-HNE 和 MDA 的积累。ROS 的过度积累导致线粒体 DNA（mtDNA）泄漏至细胞质，激活 cGAS-STING 通路，诱导 IFN-β 和 CXCL10 等干扰素刺激基因的表达。
图2 GSR 缺失增强线粒体DNA释放和STING通路激活
在体内
GSR 缺失的肿瘤细胞在免疫 competent 小鼠中生长显著受抑制。GSR 缺失肿瘤中 CD8+ T 细胞浸润显著增加，PD-1 表达降低，提示 T 细胞耗竭减轻。
图3 GSR 缺失诱导的肿瘤抑制通过铁死亡和铜死亡发生
03. 机制揭秘
ROS 放大驱动 mtDNA 释放与 STING 激活
GSR 缺失如何激活 cGAS-STING？本研究通过一系列实验揭示了这一机制。
ROS 是核心信使
GSR 缺失导致 GSH 还原能力下降，ROS 清除受阻，细胞内 ROS 水平显著升高。使用 ROS 清除剂 N-乙酰半胱氨酸（NAC）可以完全逆转 GSR 缺失诱导的 STING 激活和 ICD 标志物释放。
图4 GSR 缺失以 GSR 依赖的方式增强抗肿瘤疗效
mtDNA 是 STING 的配体
ROS 过度积累导致线粒体膜通透性增加，mtDNA 泄漏至细胞质。细胞质 mtDNA 被 cGAS 识别，激活 STING-TBK1-IRF3 通路。敲低 cGAS 或 STING 可显著抑制 GSR 缺失诱导的 IFN-β 分泌和 ICD。
与铁死亡/铜死亡的关联
铁死亡诱导剂和铜死亡诱导剂均通过不同机制增加 ROS。GSR 缺失放大了这一效应，使 ROS 积累超过细胞抗氧化阈值，从而触发 mtDNA 释放和 STING 激活。这解释了为什么 GSR 缺失同时增强铁死亡和铜死亡的免疫原性——两者共享 ROS 放大的共同通路。
图5 GSR 缺失与免疫检查点抑制剂（ICI）治疗产生协同作用
04. 网络特性
GSH/GSR 轴与 STING 通路的协同放大
本研究进一步发现，GSR 缺失不仅通过 ROS 激活 STING，STING 通路的激活还反过来进一步抑制 GSH 合成，形成正反馈放大环路。这种“ROS-STING-GSH”的相互调控网络，使得 GSR 缺失的肿瘤细胞陷入“免疫原性死亡-免疫激活”的良性循环。
研究成果总结
一个全新的代谢-免疫调控范式
本研究系统性地揭示了 GSH/GSR 代谢轴作为铁死亡和铜死亡免疫原性核心调控因子的分子机制。其核心逻辑如下：
“ROS 放大 → mtDNA 释放 → cGAS-STING 激活 → ICD 增强 → T 细胞浸润 → 肿瘤抑制”
图6 GSR 缺失连接铁死亡、铜死亡与 cGAS-STING 介导的免疫原性细胞死亡的模型示意图
GSR 缺失导致 GSH 还原能力下降，ROS 清除受阻，ROS 水平升高。ROS 过度积累导致线粒体损伤和 mtDNA 泄漏，激活 cGAS-STING 通路。STING 激活诱导 I 型干扰素分泌，促进树突状细胞成熟和抗原呈递，增强 CD8⁺ T 细胞浸润和杀伤功能。同时，STING 激活进一步抑制 GSH 合成，形成正反馈放大环路。
该研究将 GSH/GSR 轴从单纯的抗氧化代谢节点，提升为肿瘤免疫原性调控的核心执行者，为代谢干预联合免疫治疗提供了全新策略。
研究的创新与突破
① 概念创新
首次将 GSH/GSR 代谢轴确立为铁死亡和铜死亡免疫原性的共同调控节点，打破了以往将铁死亡和铜死亡视为独立死亡通路的认知。
② 机制创新
揭示了“ROS 放大 → mtDNA 释放 → cGAS-STING 激活”这一代谢-免疫信号转导通路，为非经典 ICD 机制提供了清晰的分子模型。
③ 系统特性创新
发现了 GSH/GSR 轴与 STING 通路之间的正反馈放大网络，解释了代谢干预如何将免疫抑制性肿瘤转化为免疫激活状态。
④ 转化创新
GSR 抑制剂与免疫检查点阻断的联合策略在多种肿瘤模型中显示协同效应，为临床转化提供了临床前证据。
未来临床应用潜力与展望
这项基础研究的发现，为肿瘤免疫治疗带来了极具潜力的转化前景：
新型免疫治疗联合策略：
GSR 抑制剂有望成为免疫检查点阻断的增效剂，将“冷肿瘤”转化为“热肿瘤”，扩大免疫治疗受益人群。
代谢标志物指导的精准治疗：
GSR 表达水平或 GSH/GSSG 比值，有望成为预测免疫治疗响应的新型生物标志物。
铁死亡/铜死亡诱导剂的优化：
基于 GSR 缺失增强免疫原性的机制，未来可开发靶向 GSH/GSR 轴的小分子药物，与铁死亡或铜死亡诱导剂联合使用。
跨瘤种应用：
GSR 在多种肿瘤中高表达，其抑制策略可能具有广谱抗肿瘤免疫激活潜力。
总之，本研究不仅深刻改变了我们对代谢应激如何调控抗肿瘤免疫的认知，更架起了一座从基础代谢研究通往临床免疫治疗改进的桥梁。
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END
ABclonal
公司简介
爱博泰克生物科技有限公司（简称：爱博泰克，ABclonal）成立于2011年，作为生命科学解决方案的提供商，旨在为全球生命科学工作者提供更好的产品与服务。公司主营业务包括抗体和分子酶试剂、生命科学仪器、药物发现CRO服务等，服务用户涵盖生命科学基础研究、转化研究、生物医药、精准医疗、体外诊断等多个领域。
ABclonal总部位于中国武汉，现有波士顿研发中心、上海诊断与科研分子酶研发中心以及武汉光谷诊断与免疫研发和生产中心。ABclonal业务遍布全球，在美国波士顿、德国、北京、天津、济南、西安、上海、武汉、南京、杭州、合肥、长沙、成都、重庆、广州和厦门建立直销团队，签约代理商近100家，覆盖全球40多个国家与地区。在过去的10年中，全球有超过100,000客户选择ABclonal。
2026-09-27
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截至09月27日15点59分，近期共有 349 本期刊发布了 1660 篇文章，其中糖尿病相关的文章共 535 篇，覆盖 37 个领域的内容。中国专家参与发表的文章有 107 篇。今日，影响因子最高的文章刊登在 Journal of hepatology (IF: 33.000) 期刊上。
今日头条
Headlines
01 Journal of hepatology IF: 33.000 多靶点血液检测用于肝细胞癌早期检测：前瞻性ALTUS研究的横断面分析
Binu V John, Mark Camardo, Amit G Singal, Neehar D Parikh, Ju Dong Yang, Lewis R Roberts, etc.
全球约有3.5亿人面临肝细胞癌风险。超声筛查虽被推荐，但早期敏感性差且依从性低。本研究旨在评估多靶点肝细胞癌血液检测对比超声在早期肝细胞癌检测中的非劣效性及特异性。
这项前瞻性、多中心研究于2021年7月至2025年6月在美国开展，纳入符合常规肝细胞癌筛查条件的肝硬化或慢性乙型肝炎病毒感染成人，进行多靶点肝细胞癌血液检测与标准超声的头对头比较。所有参与者均接受计算机断层扫描或磁共振成像作为参考标准。共同主要终点为多靶点肝细胞癌血液检测对比超声在早期肝细胞癌敏感性上的非劣效性（并序贯检验优效性）及多靶点肝细胞癌血液检测的特异性。次要终点为任何分期肝细胞癌的敏感性。
在3089例参与者中，2293例具有配对的超声和多靶点肝细胞癌血液检测结果可供评估。共检出37例肝细胞癌，其中27例根据Milan标准分类为早期。早期肝细胞癌敏感性：多靶点肝细胞癌血液检测为66.7%（95%置信区间，47.8-81.4%），超声为22.2%（95%置信区间，10.6-40.8%），证实多靶点肝细胞癌血液检测在预设的5%界值内非劣效。多靶点肝细胞癌血液检测的特异性为81.8%（95%置信区间，80.1-83.4%），未达到预设的共同主要终点82%。超声特异性为98.6%（95%置信区间，98.0-99.0%）。任何分期肝细胞癌敏感性：多靶点肝细胞癌血液检测为73.0%（95%置信区间，57.0-84.6%），超声为29.7%（95%置信区间，17.5-45.8%）。采血过程中未发生严重不良事件。
结论：多靶点肝细胞癌血液检测对早期肝细胞癌的观察敏感性高于超声，配对绝对差异为44.4%（95%置信区间，20.2-63.8%）；然而，特异性未达到预设目标。
试验注册：该试验已在ClinicalTrials.gov注册（NCT05064553）。
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Journal of hepatology | Ahead of Print.
10.1016/j.jhep.2026.09.011
02 Nature genetics IF: 29.000 全基因组图谱揭示常见与罕见变异对儿童期肥胖的影响
Katherine A Kentistou, Jonas Sundfjord, Roya Karimi, Lena R Kaisinger, Robin J Hofmeister, Nicolas Fragoso-Bargas, etc.
目前对肥胖遗传结构的认识主要基于成人研究，儿童期数据较为稀疏。为此，研究人员开展了年龄分层的遗传关联研究，针对客观测量的儿童期肥胖相关性状（n=62,276）或回忆的儿童期肥胖相关性状（有效样本量=599,924）进行分析，识别出624个与儿童期肥胖相关的常见变异，其中三分之一与成人**体重指数**没有一致关联。
与瘦素-黑素皮质素通路相关的信号（BSX、GNAS、LEPR和PCSK1）以及肠促胰岛素信号（GIPR和GLP1R）显示出对肥胖的儿童期特异性效应。单核RNA测序数据在弓状核和乳头体中识别出儿童期特异性的调节肥胖的细胞群，表明存在专门在儿童期调节肥胖的神经回路。
此外，对479,615名个体进行测序，发现了ADCY3、CALCR、MC4R、MRAP2、POMC和MYH13的罕见蛋白编码变异，这些变异在儿童期表现出比成人更强的关联。研究结果表明，儿童期为研究调节能量平衡的关键内分泌和神经肽通路提供了更敏感的窗口。
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Nature genetics | Ahead of Print.
10.1038/s41588-026-02772-y
03 Periodontology 2000 IF: 15.700 持续性高血糖对富血小板纤维蛋白介导的牙周及种植体周围组织再生的潜在影响：生物学机制与临床意义
Fawad Javed, Anton Sculean, Richard J Miron, etc.
富血小板纤维蛋白（PRF）作为一种广泛使用的自体生物材料，在牙周和种植体周围再生治疗中具有提供三维纤维蛋白支架的能力，该支架富含血小板、白细胞、生长因子和细胞因子。然而，持续性高血糖（如血糖控制不佳的糖尿病患者）会在口腔和全身组织中诱导氧化应激，并损害血管生成和细胞外基质重塑。
本综述旨在概述持续性高血糖对PRF介导的牙周和种植体周围组织再生的潜在影响，并深入理解其生物学机制和临床意义。研究问题为“持续性高血糖状态是否影响PRF介导的牙周和种植体周围组织再生？”研究者检索了索引数据库和Google Scholar，无时间和语言限制，截至2026年8月。
结果显示，评估持续性高血糖对PRF影响的证据仍然有限，主要局限于离体、体外和观察性研究。然而，现有数据一致表明，血糖控制不佳的糖尿病与PRF结构改变相关，包括孔隙率增加、凝块尺寸减小、PRF产量减少以及纤维蛋白网架组织性降低。有限证据还表明，尽管在高血糖条件下PRF的生长因子释放可能得以保留，但来自血糖控制良好的糖尿病患者的PRF在结构和生物学特征上与全身健康个体相似。这表明当血糖水平得到充分控制时，PRF的再生能力可能得以保留。
结论指出，血糖控制似乎是PRF质量和再生结局的关键决定因素。然而，缺乏评估直接再生结局的前瞻性临床研究，这凸显了需要精心设计的临床试验来阐明持续性高血糖对PRF介导的牙周和种植体周围再生的影响。
在临床相关性方面，持续性高血糖可能主要通过改变纤维蛋白结构来损害PRF的再生潜力，这可能进一步导致凝块更快分解以及在慢性炎症环境中生物反应性受损。然而，迄今为止有限的数据表明，有效的血糖控制和患者教育可能有助于保持有利于牙周和种植体周围组织再生的PRF特征。
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Periodontology 2000 | Ahead of Print.
10.1111/prd.70094
中国发表（107）
China
Biogerontology IF: 04.100Volume 27, Issue 5No.01Perilla frutescens extract reduces fat accumulation and promotes longevity in Caenorhabditis elegans via modulation of the insulin/IGF-1 signaling pathway紫苏提取物通过调控胰岛素/IGF-1信号通路减少秀丽隐杆线虫脂肪积累并促进长寿DOI: 10.1007/s10522-026-10507-z
Fish physiology and biochemistry IF: 02.500Volume 52, Issue 5No.02Short-chain fatty acids alleviate metabolic disturbances induced by high-carbohydrate diets in largemouth bass (Micropterus salmoides)短链脂肪酸缓解高碳水化合物饲料诱导的大口黑鲈（Micropterus salmoides）代谢紊乱DOI: 10.1007/s10695-026-01802-0
Metabolism IF: 11.900Ahead of Print.No.03ETS-2 deficiency impairs brown adipose tissue function through Prdm16 repressionETS-2缺失通过抑制Prdm16损害棕色脂肪组织功能DOI: 10.1016/j.metabol.2026.156788
J Physiol Biochem IF: 04.300Volume 82, Issue 1No.04Nucleotide metabolic reprogramming: a "double-edged sword" in obesity-related inflammation-from metabolic adaptation to pathological imbalance核苷酸代谢重编程：肥胖相关炎症中的“双刃剑”——从代谢适应到病理失衡DOI: 10.1007/s13105-026-01238-3
Journal of inflammation research IF: 04.100Volume 19, Issue No.05Detrimental and Beneficial Diets Regulate Acute Pancreatitis Through Convergent Gut Microbiota Pathways有害与有益饮食通过汇聚的肠道菌群途径调控急性胰腺炎DOI: 10.2147/JIR.S626690
Childhood obesity IF: 01.400Ahead of Print.No.06Effects of Recreational Soccer on Anthropometric Measures, Metabolic Markers, Physical Fitness, and Mental Health in Children and Adolescents with Overweight/Obesity: A Systematic Review and Meta-Analysis休闲足球对超重/肥胖儿童和青少年人体测量指标、代谢标志物、体能和心理健康的影响：系统综述和Meta分析DOI: 10.1177/21532176261492106
Frontiers in nutrition IF: 05.100Volume 13, Issue No.07Correction: The impact of short-term intensive fasting on physical health and gut microbiota in obese individuals更正：短期强化禁食对肥胖个体身体健康和肠道微生物群的影响DOI: 10.3389/fnut.2026.1985899
Frontiers in physiology IF: 03.400Volume 17, Issue No.08Effects of high-fat diet-induced obesity on circulating bone turnover markers in mice: a meta-analysis高脂饮食诱导的肥胖对小鼠循环骨转换标志物的影响：一项meta分析DOI: 10.3389/fphys.2026.1875466
Oncology Letters IF: 02.200Volume 32, Issue 5No.09Circulating PCSK9: A new frontier in cancer risk stratification for obese diabetics循环前蛋白转化酶枯草溶菌素/kexin 9型：肥胖糖尿病患者癌症风险分层的新前沿DOI: 10.3892/ol.2026.15856
Frontiers in immunology IF: 05.900Volume 17, Issue No.10Gut-placenta axis: gut microbiota metabolites may play a role in regulating maternal-fetal immune tolerance and the pathogenesis of adverse pregnancy outcomes肠-胎盘轴：肠道微生物群代谢物可能参与调控母胎免疫耐受及不良妊娠结局的发病机制DOI: 10.3389/fimmu.2026.1960306
Frontiers in pediatrics IF: 02.000Volume 14, Issue No.11Associations between fat-soluble vitamin status, growth, and development in Chinese children aged 3-14 years: a cross-sectional study中国3-14岁儿童脂溶性维生素状态与生长发育的关联：一项横断面研究DOI: 10.3389/fped.2026.1829557
Journal of ethnopharmacology IF: 05.400Ahead of Print.No.12Dendrobium Polysaccharides as Anti-Diabetic Agents: Hypoglycemic Mechanisms, and Structure-Activity Relationships石斛多糖作为抗糖尿病药物：降血糖机制与构效关系DOI: 10.1016/j.jep.2026.122444
Asia Pac J Ophthalmol (Phila) IF: 04.500Ahead of Print.No.13Risk factors of primary angle-closure glaucoma: An exposome-wide association study in the China Kadoorie Biobank原发性闭角型青光眼的危险因素：中国Kadoorie Biobank的全暴露组关联研究DOI: 10.1016/j.apjo.2026.100378
Experimental Eye Research IF: 02.700Ahead of Print.No.14Identification of αSMA lineage cells in the posterior limbal stroma后部角膜缘基质中αSMA谱系细胞的鉴定DOI: 10.1016/j.exer.2026.111259
Int J Biol Macromol IF: 08.500Ahead of Print.No.15A programmed oxidized alginate/chitosan sandwich-layered dressing for sequential regulation of diabetic wound healing一种程序化氧化海藻酸盐/壳聚糖三明治层状敷料用于糖尿病伤口愈合的序贯调控DOI: 10.1016/j.ijbiomac.2026.154642
The journal of immunology IF: 03.400Volume 215, Issue 9No.16Mechanism of SGLT2 inhibitors in improving immune imbalance in diabetic mice with sepsis via regulating macrophage M2 polarization through the APOC1/HMGB1/TLR4 axisSGLT2抑制剂通过APOC1/HMGB1/TLR4轴调控巨噬细胞M2极化改善糖尿病脓毒症小鼠免疫失衡的机制DOI: 10.1093/jimmun/vkag240
PeerJ IF: 02.400Volume 14, Issue No.17Integrative identification and preliminary validation of senescence-associated secretory phenotype-related candidate biomarkers in type 2 diabetes2型糖尿病中衰老相关分泌表型候选生物标志物的整合鉴定与初步验证DOI: 10.7717/peerj.21729
Infection and drug resistance IF: 02.900Volume 19, Issue No.18Discriminative Utility of Peripheral Blood Immune-Inflammatory Indices for Chronic Osteomyelitis: A Single-Center Retrospective Case-Control Study外周血免疫炎症指标对慢性骨髓炎的鉴别效用：单中心回顾性病例对照研究DOI: 10.2147/IDR.S618270
Frontiers in surgery IF: 01.800Volume 13, Issue No.19Risk factors for post-traumatic lymphedema after open fractures of the lower leg: a retrospective cohort study小腿开放性骨折后创伤后淋巴水肿的危险因素：一项回顾性队列研究DOI: 10.3389/fsurg.2026.1931485
Global Heart IF: 03.100Volume 21, Issue 1No.20Sleep Phenotype, Shift-Related Occupation, and Coronary Plaque Complexity in Young Adults: Association with CT-Derived Functional Ischemia睡眠表型、轮班相关职业与年轻成人冠状动脉斑块复杂性：与CT衍生功能性缺血的关联DOI: 10.5334/gh.1586
Global Heart IF: 03.100Volume 21, Issue 1No.21Longitudinal Trajectories of Body Roundness Index and Risk of Incident Hypertension in Non-Diabetic Elderly Adults: A Prospective Nationwide Cohort Study Involving Two Cohorts体重指数轨迹与非糖尿病老年人新发高血压风险：一项涉及两个队列的前瞻性全国性队列研究DOI: 10.5334/gh.1587
Clinical kidney journal IF: 04.600Volume 18, Issue 9No.22Bioengineered T-cell therapies for precision immunotherapy in renal transplantation, autoimmune relapse, and sensitization生物工程化T细胞疗法在肾移植、自身免疫复发和致敏中的精准免疫治疗DOI: 10.1093/ckj/sfaf248
Sexual medicine IF: 02.000Volume 14, Issue 6No.23Association between a novel nutritional-inflammatory index and testosterone levels: a cross-sectional study一种新型营养-炎症指数与睾酮水平之间的关联：一项横断面研究DOI: 10.1093/sexmed/qfag091
Front Cell Dev Biol IF: 04.300Volume 14, Issue No.24Extracellular vesicles in wound healing and scar formation: molecular regulation of macrophages, fibroblasts, and their crosstalk细胞外囊泡在伤口愈合与瘢痕形成中的作用：巨噬细胞、成纤维细胞的分子调控及其交互对话DOI: 10.3389/fcell.2026.1917543
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.25Association of finerenone with graded proteinuria improvement in type 2 diabetes with chronic kidney disease and proteinuria >1 g/d: a retrospective cohort study非奈利酮与2型糖尿病合并慢性肾脏病及蛋白尿>1 g/d患者蛋白尿分级改善的关联：一项回顾性队列研究DOI: 10.3389/fendo.2026.1908577
PeerJ IF: 02.400Volume 14, Issue No.26Development and validation of a risk prediction model for postoperative frailty in breast cancer patients乳腺癌患者术后衰弱风险预测模型的开发与验证DOI: 10.7717/peerj.21733
Endocrine IF: 02.900Volume 91, Issue 1No.27Co-occurrence patterns and related risk factors of type 2 diabetes mellitus and metabolic dysfunction-associated steatotic liver disease2型糖尿病与代谢功能障碍相关脂肪性肝病的共现模式及相关风险因素DOI: 10.1007/s12020-026-04810-5
Frontiers in public health IF: 03.400Volume 14, Issue No.28Systematic review and meta-analysis of risk prediction models for anti-tuberculosis drug-induced liver injury in East Asian populations东亚人群抗结核药物性肝损伤风险预测模型的系统评价与Meta分析DOI: 10.3389/fpubh.2026.1958154
Talanta IF: 06.100Ahead of Print.No.29Quantitative detection of the diabetic retinopathy-associated microRNA-1281 via a CRISPR/Cas12a-RCA ratiometric sensing platform基于CRISPR/Cas12a-RCA比率传感平台的糖尿病视网膜病变相关microRNA-1281定量检测DOI: 10.1016/j.talanta.2026.130655
Clinical ophthalmology IF: 02.200Volume 20, Issue No.30Advanced Glycation End Products and Metabolic-Mechanical Coupling in Diabetic Retinopathy晚期糖基化终末产物与糖尿病视网膜病变中的代谢-力学耦合DOI: 10.2147/OPTH.S635236
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.31A six-metabolite signature characterizes metabolically unhealthy obesity and reveals hidden metabolic risk within metabolically healthy obesity六种代谢物特征可区分代谢不健康型肥胖并揭示代谢健康型肥胖中的隐藏代谢风险DOI: 10.3389/fendo.2026.1910610
Medicine IF: 01.400Volume 105, Issue 39No.32Association of the composite dietary antioxidant index with advanced cardiovascular-kidney-metabolic syndrome in U.S. adults: A cross-sectional study based on NHANES 2001-2018复合膳食抗氧化指数与美国成人晚期心血管-肾脏-代谢综合征的关联：基于NHANES 2001-2018的横断面研究DOI: 10.1097/MD.0000000000050849
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.33Dose-response and time-course effects of ecnoglutide in type 2 diabetes: a systematic review and meta-analysis of efficacy埃诺格鲁肽治疗2型糖尿病的剂量-反应与时间-效应：有效性的系统评价与荟萃分析DOI: 10.3389/fendo.2026.1934027
Front Cell Dev Biol IF: 04.300Volume 14, Issue No.34Mitochondrial Ca2+ homeostasis in ovarian function and oocyte competence: from molecular transporters to early embryonic development卵巢功能与卵母细胞能力中的线粒体钙稳态：从分子转运体到早期胚胎发育DOI: 10.3389/fcell.2026.1963467
Frontiers in public health IF: 03.400Volume 14, Issue No.35Prevalence, functional impact, and associated factors of knee osteoarthritis and knee pain among adults in Urumqi, Northwest China: a community-based cross-sectional study中国西北乌鲁木齐成年人膝骨关节炎与膝痛的患病率、功能影响及相关因素：一项基于社区的横断面研究DOI: 10.3389/fpubh.2026.1903768
Nutrients IF: 05.000Volume 18, Issue 18No.36Self-Reported Chronotype and Diet Quality in Chinese Adolescents: Insights from a Cross-Sectional Study in Xiamen中国青少年自我报告睡眠时型与饮食质量：来自厦门横断面研究的见解DOI: 10.3390/nu18183097
Nutrients IF: 05.000Volume 18, Issue 18No.37Dietary Behaviours Mediate Intervention Effects on Body Composition Outcomes in Children: Evidence from a Cluster-Randomised Controlled Trial饮食行为在儿童身体成分干预效果中的中介作用：来自整群随机对照试验的证据DOI: 10.3390/nu18183051
Nutrients IF: 05.000Volume 18, Issue 18No.38Zanthoxylum bungeanum Essential Oil Alleviates Obesity and Dysregulated Lipid Metabolism in Diet-Induced Obese Mice: A Multi-Omics Study Linking Gut Microbiota to Fatty Acid Metabolism花椒精油缓解饮食诱导肥胖小鼠的肥胖和脂质代谢紊乱：一项连接肠道菌群与脂肪酸代谢的多组学研究DOI: 10.3390/nu18182950
Microorganisms IF: 04.200Volume 14, Issue 9No.39Lactational Enrofloxacin Exposure Promotes Offspring Lipid Metabolic Disorder and Adiposity Involving Gut Microbiota-Derived LPS and PPARγ Signaling哺乳期恩诺沙星暴露通过肠道菌群来源的LPS和PPARγ信号促进子代脂质代谢紊乱和肥胖DOI: 10.3390/microorganisms14091964
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.40Extracellular Vesicle-Mediated Local and Systemic Communication in Metabolic Diseases细胞外囊泡介导的代谢性疾病局部与全身通讯DOI: 10.3390/ijms27188287
Gels IF: 05.300Volume 12, Issue 9No.41A Comparative Study of Commercial 3D Printers for Food Fabrication Based on Printing Ink Gels基于打印墨水凝胶的商用食品3D打印机的比较研究DOI: 10.3390/gels12090777
Foods IF: 05.100Volume 15, Issue 18No.42Bioactive Compounds from Edible and Medicinal Mushrooms in Obesity-Depression Comorbidity: Gut-Brain Axis Mechanisms and Functional Food Perspectives食用和药用蘑菇中的生物活性化合物在肥胖-抑郁共病中的作用：肠-脑轴机制与功能食品前景DOI: 10.3390/foods15183265
Healthcare IF: 02.700Volume 14, Issue 18No.43Association of Estimated Pulse Wave Velocity with Chronic Kidney Disease Risk: A Machine Learning Analysis Based on NHANES and CHARLS估算脉搏波速度与慢性肾脏病风险的关联：基于NHANES和CHARLS的机器学习分析DOI: 10.3390/healthcare14183125
Biomolecules IF: 04.800Volume 16, Issue 9No.44Metabolic Vulnerability and Regenerative Failure of the External Urethral Sphincter: A Ferroptosis-Associated Framework for Stress Urinary Incontinence外尿道括约肌的代谢脆弱性与再生失败：压力性尿失禁的铁死亡相关框架DOI: 10.3390/biom16091376
Biomedicines IF: 03.900Volume 14, Issue 9No.45FTO-Driven m6A Demethylation of TNC Promotes Epithelial-Mesenchymal Transition and Gastric Cancer MetastasisFTO驱动的TNC m6A去甲基化促进上皮-间质转化和胃癌转移DOI: 10.3390/biomedicines14091958
Am J Respir Crit Care Med IF: 19.400Ahead of Print.No.46The Synergistic Risk of Respiratory Effort and Obesity Phenotype in OSA Prognosis呼吸努力与肥胖表型在OSA预后中的协同风险DOI: 10.1093/ajrccm/aamag516
International journal of obesity IF: 03.800Ahead of Print.No.47Bidirectional crosstalk between obesity and the lymphatic system: a novel pathway in obesity pathogenesis and treatment肥胖与淋巴系统之间的双向交互作用：肥胖发病机制与治疗的新途径DOI: 10.1038/s41366-026-02178-0
Biomolecules IF: 04.800Volume 16, Issue 9No.48Associations of ASIC2, IKZF3, and GSDMB Variants with Gestational Diabetes Mellitus and Their Interactions with Environmental Exposures Among Chinese WomenASIC2、IKZF3和GSDMB基因变异与妊娠期糖尿病的关联及其与环境暴露的交互作用：一项中国女性研究DOI: 10.3390/biom16091373
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.49Effects of short-bout accumulated physical activity and sedentary-break interventions on continuous glucose monitoring metrics in adults with type 2 diabetes: A systematic review and meta-analysis短时累积体力活动与久坐中断干预对成人2型糖尿病患者连续血糖监测指标的影响：系统综述与荟萃分析DOI: 10.3389/fendo.2026.1901259
Frontiers in oncology IF: 03.300Volume 16, Issue No.50Metaplastic breast cancer: a clinicopathological analysis of nine cases highlighting diagnostic challenges and aggressive behavior化生性乳腺癌：九例临床病理分析揭示诊断挑战与侵袭性行为DOI: 10.3389/fonc.2026.1852513
J Diabetes Investig IF: 03.000Ahead of Print.No.51M1 macrophage-derived exosomes aggravate diabetic nephropathy by regulating the WTAP/S1PR2 axisM1巨噬细胞来源的外泌体通过调控WTAP/S1PR2轴加重糖尿病肾病DOI: 10.1111/jdi.70446
Microorganisms IF: 04.200Volume 14, Issue 9No.52Advances in the Production of D-Tagatose Using L-Arabinose Isomerase利用L-阿拉伯糖异构酶生产D-塔格糖的研究进展DOI: 10.3390/microorganisms14092085
Microorganisms IF: 04.200Volume 14, Issue 9No.53Association Between Thiazolidinedione Therapy and Tuberculosis-Related Events in Type 2 Diabetes: A Population-Based Cohort Study噻唑烷二酮类药物治疗与2型糖尿病中结核病相关事件之间的关联：一项基于人群的队列研究DOI: 10.3390/microorganisms14091979
Life IF: 03.400Volume 16, Issue 9No.54Correction: Lin et al. Cordyceps militaris Enhances Wound Repair Through Regulation of HIF-1α, TGF-β1, and SIRT1/Nrf2/HO-1 Signaling in Diabetic Skin. Life 2026, 16, 117更正：Lin等。蛹虫草通过调控HIF-1α、TGF-β1和SIRT1/Nrf2/HO-1信号通路增强糖尿病皮肤伤口修复。Life 2026, 16, 117DOI: 10.3390/life16091415
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.55Ceria-Based Nanotherapeutics for Inflammatory Skin Disorders: From Design and Mechanisms to Advanced Delivery and Future Perspectives基于氧化铈的纳米治疗剂用于炎症性皮肤病：从设计与机制到先进递送及未来展望DOI: 10.3390/ijms27188243
Gels IF: 05.300Volume 12, Issue 9No.56Multifunctional Intelligent Hydrogels Based on MnO2 Nanozymes and Ca2+ Signal Regulation for Diabetic Wound Repair基于MnO2纳米酶和Ca2+信号调节的多功能智能水凝胶用于糖尿病伤口修复DOI: 10.3390/gels12090826
Gels IF: 05.300Volume 12, Issue 9No.57Study on Berberine/Glycyrrhizic Acid Monoammonium Salt Self-Assembled Hydrogel for Diabetic Wound Healing小檗碱/甘草酸单铵盐自组装水凝胶用于糖尿病伤口愈合的研究DOI: 10.3390/gels12090799
Foods IF: 05.100Volume 15, Issue 18No.58Reconstituted Rice with Low-Glycemic-Index Potential as an Alternative to Polished Rice: Structural, Cooking, Nutritional, and In Vitro Digestibility Attributes具有低血糖指数潜力的重组米作为精白米替代品：结构、蒸煮、营养及体外消化特性DOI: 10.3390/foods15183297
Healthcare IF: 02.700Volume 14, Issue 18No.59The Double-Edged Nature of Patient-to-Patient Interactions in Digital Healthcare Communities: A Qualitative Study of Patients with Type 2 Diabetes in China数字医疗社区中患者间互动的双刃剑性质：中国2型糖尿病患者的定性研究DOI: 10.3390/healthcare14183025
Healthcare IF: 02.700Volume 14, Issue 18No.60Differential Associations of Healthy Lifestyle Latent Classes with Glycemic Transitions in Prediabetes: An Observational Study Based on CHARLS健康生活方式潜在类别与糖尿病前期血糖转归的差异关联：基于CHARLS的观察性研究DOI: 10.3390/healthcare14182966
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.61γ-Aminobutyric Acid Alleviates Cadmium Toxicity and Is Associated with Increased Ascorbate and Glutathione Levels in Brassica Speciesγ-氨基丁酸缓解镉毒性并与Brassica物种中抗坏血酸和谷胱甘肽水平升高相关DOI: 10.3390/ijms27188394
Toxics IF: 04.100Volume 14, Issue 9No.62Mixed Exposure to Underground Air Pollutants and Metabolic Syndrome in Coal Miners: A Cross-Sectional Study Integrating Multi-Pollutant Models and Urinary Metabolomics煤矿工人井下空气污染物混合暴露与代谢综合征：整合多污染物模型与尿液代谢组学的横断面研究DOI: 10.3390/toxics14090746
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.63Routine Laboratory Parameters in the Differentiation of Spinal Cord Infarction and Seronegative Acute Myelitis: A Retrospective Study常规实验室参数在脊髓梗死与血清阴性急性脊髓炎鉴别诊断中的价值：一项回顾性研究DOI: 10.3390/jcm15187083
Bioengineering IF: 03.700Volume 13, Issue 9No.64Long-Term Air Pollution Exposure, Cardiovascular Disease, and Cardiometabolic Risk Factors in Middle-Aged and Older Chinese Adults: A Prospective Cohort Study中国中老年人群长期空气污染暴露、心血管疾病与心血管代谢危险因素：一项前瞻性队列研究DOI: 10.3390/bioengineering13090958
Biomolecules IF: 04.800Volume 16, Issue 9No.65The Heart-Kidney Axis in Heart Failure and Chronic Kidney Disease: Mechanisms, Mediators, and Therapeutic Implications心力衰竭与慢性肾脏病中的心肾轴：机制、介质与治疗意义DOI: 10.3390/biom16091241
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.66First-trimester calculated remnant cholesterol and gestational diabetes mellitus in twin pregnancies: a retrospective cohort study双胎妊娠孕早期计算残余胆固醇与妊娠期糖尿病：一项回顾性队列研究DOI: 10.3389/fendo.2026.1882821
Foods IF: 05.100Volume 15, Issue 18No.67Dual Modulation of Lipid Metabolism by Adzuki Bean (Vigna angularis) Saponins Involving PPARα/γ Signaling and Gut Microbiota Remodeling in Obesogenic Diet-Induced Obese Mice赤小豆皂苷通过PPARα/γ信号通路与肠道菌群重塑对肥胖饮食诱导肥胖小鼠脂质代谢的双重调控DOI: 10.3390/foods15183276
Curr Issues Mol Biol IF: 03.000Volume 48, Issue 9No.68Ferroptosis Signatures in Diabetic Cardiomyopathy: Multi-Omics Discovery and Validation of ACOT1 and TXNIP糖尿病心肌病中的铁死亡特征：ACOT1和TXNIP的多组学发现与验证DOI: 10.3390/cimb48090923
Foods IF: 05.100Volume 15, Issue 18No.69Vincoside Lactam from Edible Uncaria rhynchophylla: A Food-Derived Indole Alkaloid for Dietary Postprandial Glycemic Regulation and Functional Food Development来自可食用钩藤的Vincoside Lactam：一种用于膳食餐后血糖调节和功能食品开发的食品源吲哚生物碱DOI: 10.3390/foods15183329
Genes IF: 02.800Volume 17, Issue 9No.70An Exploratory Single-Cell Analysis Identifies Candidate Shared Molecular Features in Proliferative Diabetic Retinopathy and Parkinson's Disease探索性单细胞分析识别增殖性糖尿病视网膜病变与帕金森病中候选共享分子特征DOI: 10.3390/genes17091004
Frontiers in oncology IF: 03.300Volume 16, Issue No.71The effects of combined aerobic and resistance exercise on metabolic blood biomarkers and quality of life in patients with breast cancer: a systematic review meta-analysis有氧联合抗阻运动对乳腺癌患者代谢血液生物标志物及生活质量的影响：一项系统综述与荟萃分析DOI: 10.3389/fonc.2026.1900945
Journal of diabetes research IF: 03.400Volume 2026, Issue 1No.72Effects of Different Exogenous Insulin Analog Treatments on the Evaluation of Pancreatic Islet Function in Diabetes不同外源性胰岛素类似物治疗对糖尿病胰岛功能评估的影响DOI: 10.1155/jdr/2572581
Medicine IF: 01.400Volume 105, Issue 39No.73The association between dietary protein and gallstones in adults under 60 years old: A cross-sectional study60岁以下成年人膳食蛋白质与胆结石的关联：一项横断面研究DOI: 10.1097/MD.0000000000050845
Medicine IF: 01.400Volume 105, Issue 39No.74Systematic review and meta-analysis of biomarkers of sarcopenia and sarcopenic obesity肌少症与肌少症性肥胖生物标志物的系统综述与Meta分析DOI: 10.1097/MD.0000000000050799
Medicine IF: 01.400Volume 105, Issue 39No.75Association between the C-Reactive protein-triglyceride-glucose index and osteoarthritis risk in prediabetic mellitus adults: A longitudinal analysis from the China health and retirement longitudinal studyC反应蛋白-甘油三酯-葡萄糖指数与糖尿病前期成人骨关节炎风险之间的关联：来自中国健康与养老追踪调查的纵向分析DOI: 10.1097/MD.0000000000050774
Veterinary sciences IF: 02.300Volume 13, Issue 9No.76Plant-Derived Exosome-like Nanovesicles for Metabolic Dysfunction-Associated Steatotic Liver Disease植物来源外泌体样纳米囊泡用于代谢功能障碍相关脂肪性肝病DOI: 10.3390/vetsci13090851
Pharmaceuticals IF: 04.800Volume 19, Issue 9No.77Natural Small Molecules Targeting Mitochondrial Quality Control for the Treatment of Metabolic Diseases: Mechanisms, Novel Formulations, and Translational Perspectives靶向线粒体质量控制治疗代谢疾病的天然小分子：机制、新型制剂与转化前景DOI: 10.3390/ph19091402
Pharmaceutics IF: 05.500Volume 18, Issue 9No.78Intra-Subject Variability in Pharmacokinetics and Pharmacodynamics of Basal Insulin at Two Single-Dose Levels: Findings from Euglycemic Glucose Clamp Bioequivalence Studies of Insulin Degludec基础胰岛素在两个单剂量水平下的药代动力学和药效学个体内变异性：来自胰岛素德谷葡萄糖钳夹生物等效性研究的发现DOI: 10.3390/pharmaceutics18091051
Nutrients IF: 05.000Volume 18, Issue 18No.79Fatty Acid Composition, Molecular Species, and Ameliorating Effects of Tilapia Head Phospholipids on High-Fat Diet-Induced Metabolic Syndrome in Mice罗非鱼头磷脂的脂肪酸组成、分子种及其对高脂饮食诱导小鼠代谢综合征的改善作用DOI: 10.3390/nu18183076
Nutrients IF: 05.000Volume 18, Issue 18No.80Avenanthramides in Obesity-Related Metabolic Dysfunction: Mechanisms, Evidence Attribution, and Translational Priorities燕麦蒽酰胺在肥胖相关代谢功能障碍中的作用：机制、证据归因与转化优先事项DOI: 10.3390/nu18183066
Microorganisms IF: 04.200Volume 14, Issue 9No.81Microbiota-Mediator-Host Signaling Networks in Metabolic Syndrome: From Mechanistic Insights to Therapeutic Targeting代谢综合征中的微生物群-介质-宿主信号网络：从机制见解到治疗靶向DOI: 10.3390/microorganisms14091865
Life IF: 03.400Volume 16, Issue 9No.82Acute Endocrine and Lipid Responses to Extreme Ultramarathon Running Across 100, 308, and 622 km Events100、308和622公里极限超级马拉松跑步的急性内分泌和脂质反应DOI: 10.3390/life16091450
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.83CRISPR Technologies in Type 2 Diabetes: From Mechanistic Insights to Therapeutic DiscoveryCRISPR技术在2型糖尿病中的应用：从机制洞察到治疗发现DOI: 10.3390/ijms27188360
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.84Wheat Bioactive Compounds and Human Health: A Review of Nutraceutical Potential, Molecular Mechanisms and AI-Assisted Functional Food Innovation小麦生物活性化合物与人类健康：营养保健品潜力、分子机制及人工智能辅助功能性食品创新综述DOI: 10.3390/ijms27188290
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.85Overweight/Obesity and Hyperinsulinemia Impair Oocyte Developmental Competence via Cumulus Cell Dysfunction and Oxidative Stress-Mediated Follicular Microenvironment Remodeling超重/肥胖与高胰岛素血症通过卵丘细胞功能障碍和氧化应激介导的卵泡微环境重塑损害卵母细胞发育能力DOI: 10.3390/ijms27188246
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.86Hypoxic Exercise Alleviates Diabetic Skeletal Myopathy in Zebrafish in Association with Hif1a/Foxo3a Signaling and Mitochondrial Quality Control低氧运动通过Hif1a/Foxo3a信号通路和线粒体质量控制缓解斑马鱼糖尿病性骨骼肌病DOI: 10.3390/ijms27188034
Curr Issues Mol Biol IF: 03.000Volume 48, Issue 9No.87Camellia nitidissima Flower Extract Alleviates Dermal Papilla Cell Dysfunction by Regulating 11β-HSD1 and the TGF-β2/Smad and Wnt/β-Catenin Pathways金花茶花提取物通过调控11β-HSD1及TGF-β2/Smad和Wnt/β-Catenin通路缓解真皮乳头细胞功能障碍DOI: 10.3390/cimb48090954
Genes IF: 02.800Volume 17, Issue 9No.88Mosaic Trisomy 14 with Severe Short Stature: A Case Report伴有严重矮小症的14号染色体嵌合三体：一例病例报告DOI: 10.3390/genes17091123
Biomedicines IF: 03.900Volume 14, Issue 9No.89Pathogenesis-Informed Phenotype-Guided Therapy for MASH: A Three-Axis Translational Framework Within the MASLD Spectrum基于发病机制的MASH表型指导治疗：MASLD谱系内的三轴转化框架DOI: 10.3390/biomedicines14091884
Biomedicines IF: 03.900Volume 14, Issue 9No.90Association of the Pan-Immune-Inflammation Value-to-Albumin Ratio as a Novel Cardiovascular Disease Predictor in Type 2 Diabetes: A Prospective Cohort Study泛免疫炎症值-白蛋白比值作为2型糖尿病新型心血管疾病预测因子的关联：一项前瞻性队列研究DOI: 10.3390/biomedicines14091878
Antioxidants IF: 06.600Volume 15, Issue 9No.91Molecular Mechanisms of Obesity-Associated Oxidative Stress and Therapeutic Strategies肥胖相关氧化应激的分子机制及治疗策略DOI: 10.3390/antiox15091193
BMC Cardiovascular Disorders IF: 02.300Volume 26, Issue 1No.92Association between the triglyceride-glucose-body mass index and the risk of early vascular aging in young and middle-aged Chinese adults: a cross-sectional study甘油三酯-葡萄糖-体重指数与中青年中国成年人早期血管老化风险之间的关联：一项横断面研究DOI: 10.1186/s12872-026-06239-0
Pharmaceuticals IF: 04.800Volume 19, Issue 9No.93PRDM16 as a Multifaceted Pharmacological Target in Kidney Diseases: From Epigenetic Mechanisms to Therapeutic StrategiesPRDM16作为肾脏疾病的多面药理学靶点：从表观遗传机制到治疗策略DOI: 10.3390/ph19091469
Frontiers in public health IF: 03.400Volume 14, Issue No.94Changes in short-chain fatty acids across the glycemic spectrum: a systematic review and meta-analysis短链脂肪酸在血糖谱中的变化：一项系统综述与荟萃分析DOI: 10.3389/fpubh.2026.1912172
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.95Higher visceral fat area is inversely associated with ketosis in Chinese patients with type 2 diabetes mellitus: a cross-sectional study中国2型糖尿病患者中较高的内脏脂肪面积与酮症呈负相关：一项横断面研究DOI: 10.3389/fendo.2026.1948929
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.96The effectiveness of self-care interventions in working-age adults with type 2 diabetes mellitus: a systematic review and meta-analysis自我护理干预对工作年龄2型糖尿病成人患者的有效性：系统综述与荟萃分析DOI: 10.3389/fendo.2026.1941060
Medicine IF: 01.400Volume 105, Issue 39No.97Association between atherogenic index of plasma and depression in patients with type 2 diabetes mellitus: A cross-sectional study血浆致动脉粥样硬化指数与2型糖尿病患者抑郁之间的关联：一项横断面研究DOI: 10.1097/MD.0000000000050889
Pharmaceuticals IF: 04.800Volume 19, Issue 9No.98Consensus In Silico Pharmacodynamic Screening of Twelve Fabaceae Isoflavones Targeting Glycation, Oxidative Stress, Antidiabetic Activity, and NF-κB-Related Inflammation针对糖化、氧化应激、抗糖尿病活性及NF-κB相关炎症的十二种豆科异黄酮共识性计算机药效学筛选DOI: 10.3390/ph19091353
Nutrients IF: 05.000Volume 18, Issue 18No.99Serum Levels of 18 Trace Elements and Type 2 Diabetes Mellitus: A Propensity Score-Matched Case-Control Study in Northwest Chinese Adults18种微量元素血清水平与2型糖尿病：中国西北地区成人倾向性评分匹配病例对照研究DOI: 10.3390/nu18183068
Diagnostics IF: 03.300Volume 16, Issue 18No.100Establishment of Serum Cholesterol Sulfate Reference Intervals and Evaluation of Its Diagnostic and Metabolic Associations in Chinese Adults中国成人血清硫酸胆固醇参考区间的建立及其诊断与代谢关联评估DOI: 10.3390/diagnostics16182953
Biomolecules IF: 04.800Volume 16, Issue 9No.101Targeted Regulation of Pancreatic Islet Function by Natural Products Against Type 2 Diabetes Mellitus: Advances and Prospects天然产物靶向调控胰岛功能对抗2型糖尿病：进展与前景DOI: 10.3390/biom16091338
Biomedicines IF: 03.900Volume 14, Issue 9No.102Echinatin Ameliorates Insulin Resistance and Hepatic Lipid Accumulation in db/db MiceEchinatin改善db/db小鼠的胰岛素抵抗和肝脏脂质积累DOI: 10.3390/biomedicines14092091
Drugs IF: 14.400Ahead of Print.No.103GLP-1 Receptor Agonists in Heart Failure: A Systematic Review and Meta-analysis with Phenotype-Specific Effects and Dual Analytical FrameworksGLP-1受体激动剂在心力衰竭中的应用：一项具有表型特异性效应和双重分析框架的系统评价与荟萃分析DOI: 10.1007/s40265-026-02380-4
Scand Cardiovasc J IF: 01.000Ahead of Print.No.104Responder Analysis of Adaptive Postural Balance Cardiac Rehabilitation Exercise in Patients with Coronary Artery Disease and Type 2 Diabetes: Secondary Analysis of a Randomized Trial适应性姿势平衡心脏康复运动在冠状动脉疾病合并2型糖尿病患者中的应答者分析：一项随机试验的二次分析DOI: 10.1080/14017431.2026.2732500
Medicine IF: 01.400Volume 105, Issue 39No.105Quantitative evaluation of the effect of hyperlipidemia on carotid artery stiffness in patients with type 2 diabetes mellitus using shear wave elastography剪切波弹性成像定量评估高脂血症对2型糖尿病患者颈动脉僵硬度的影响DOI: 10.1097/MD.0000000000050829
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.106Iron, Copper, and Zinc Dyshomeostasis in Cardiovascular and Cerebrovascular Diseases: Redox Mechanisms, Evidence Levels, and Translational Prospects心血管和脑血管疾病中铁、铜和锌的稳态失衡：氧化还原机制、证据级别和转化前景DOI: 10.3390/ijms27188053
Biomolecules IF: 04.800Volume 16, Issue 9No.107Decreased Plasma IGF-1 Is Associated with Cortical Atrophy, but Not Concomitant Cerebrovascular Disease in Alzheimer's Dementia血浆胰岛素样生长因子1降低与阿尔茨海默病痴呆的皮质萎缩相关，但与伴随的脑血管疾病无关DOI: 10.3390/biom16091248
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J Diabetes Metab Disord IF: 01.600Volume 25, Issue 2No.02Pooled prevalence of anxiety and depressive symptoms among adults with type 2 diabetes: a systematic review and meta-analysisDOI: 10.1007/s40200-026-02079-z
J Diabetes Metab Disord IF: 01.600Volume 25, Issue 2No.03Pulmonary embolism and diabetes-related-mortality in United States: temporal trends and epidemiologic shiftsDOI: 10.1007/s40200-026-02092-2
Frontiers in nutrition IF: 05.100Volume 13, Issue No.04Preoperative oral carbohydrate administration in adult elective surgery: protocol heterogeneity, regional practice patterns and evidence gaps-a scoping reviewDOI: 10.3389/fnut.2026.1943627
Euroasian J HepatogastroenterolVolume 16, Issue 1No.05Predictors of Mortality in End-stage Renal Disease Patients Presenting with Upper Gastrointestinal BleedingDOI: 10.5005/jp-journals-10018-1499
Tissue & cell IF: 02.500Ahead of Print.No.06Empagliflozin shields brain from methotrexate toxicity: Nrf2/HO-1/GPX4 activation prevents ferroptosis and chemo-brain in ratsDOI: 10.1016/j.tice.2026.103975
J Am Acad Dermatol IF: 11.800Ahead of Print.No.07Metformin as a Senomorphic Adjunct in Immune-Mediated DermatosesDOI: 10.1016/j.jaad.2026.08.128
Biomedicine & pharmacotherapy IF: 07.500Ahead of Print.No.08Spheroid maturation determines drug response and establishes a mechanism-informed framework for analytical endpoint validation in three-dimensional lung cancer modelsDOI: 10.1016/j.biopha.2026.119952
Euroasian J HepatogastroenterolVolume 16, Issue 1No.09Necrotizing Oesophagitis Associated with Ketoacidosis: A Case Series Exploring the Diagnostic Dilemma of Metabolic Overlap SyndromesDOI: 10.5005/jp-journals-10018-1507
Frontiers in immunology IF: 05.900Volume 17, Issue No.10Integrative single-cell and bulk transcriptomics uncovers a lipid metabolism-related lncRNA signature alongside the ELFN1-AS1/LYPLA1 axis driving osteosarcoma progressionDOI: 10.3389/fimmu.2026.1945005
J Diabetes Metab Disord IF: 01.600Volume 25, Issue 2No.11Cumulative non-HDL cholesterol exposure and risk of cardiovascular-kidney-metabolic syndrome progression: a nationwide longitudinal study from CHARLSDOI: 10.1007/s40200-026-02090-4
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.12Serum magnesium and major adverse cardiovascular events in patients with diabetic foot ulcers: a retrospective cohort studyDOI: 10.3389/fendo.2026.1938560
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.13The association between maternal diabetes and the risk of epilepsy in offspring: a systematic review and meta-analysis母亲糖尿病与子代癫痫风险之间的关联：一项系统评价与荟萃分析DOI: 10.3389/fendo.2026.1960502
Nutrition IF: 03.000Ahead of Print.No.14Short-term macronutrient-specific diets induce distinct metabolic changes detectable in blood and saliva短期特定宏量营养素饮食诱导可在血液和唾液中检测到的不同代谢变化DOI: 10.1016/j.nut.2026.113412
Endocrinology IF: 03.300Ahead of Print.No.15Free fatty acid receptor 4 agonism stimulates insulin secretion via different mechanisms in mouse versus human islets游离脂肪酸受体4激动剂在小鼠与人类胰岛中通过不同机制刺激胰岛素分泌DOI: 10.1210/endocr/bqag111
Vet Res Commun IF: 02.000Volume 50, Issue 6No.16A methyl donor and an essential oil: Performance, economic efficiency, serum biochemistry, histomorphometry, and appetite/growth-related gene expression in broilers甲基供体与精油：肉鸡生产性能、经济效益、血清生化、组织形态计量及食欲/生长相关基因表达DOI: 10.1007/s11259-026-11523-7
Journal of animal science IF: 02.900Ahead of Print.No.17Supplementation with Bacillus-based direct-fed microbials for developing beef heifers: impacts on fecal and vaginal microbiome, growth, and reproductive performance基于芽孢杆菌的直接饲喂微生物制剂对发育期肉牛母牛补充：对粪便和阴道微生物组、生长及繁殖性能的影响DOI: 10.1093/jas/skag313
Curēus IF: 01.300Volume 18, Issue 8No.18Iatrogenic Dextrose Hyperosmolar Extravasation Injury in Suspected Endogenous Hyperinsulinism疑似内源性高胰岛素血症中高渗葡萄糖外渗性损伤的医源性病例DOI: 10.7759/cureus.115223
The FEBS journal IF: 04.200Ahead of Print.No.19Drosophila midgut tumor-induced insulin resistance systemically remodels lymph gland hematopoiesis during cancer cachexia果蝇中肠肿瘤诱导的胰岛素抵抗在癌症恶病质中系统性重塑淋巴腺造血DOI: 10.1111/febs.70741
ACS physical chemistry Au IF: 04.300Volume 6, Issue 5No.20Characterization of the pH-Dependent Stabilizing Forces of Insulin's Native and Fibril States胰岛素天然态与纤维态pH依赖性稳定力的表征DOI: 10.1021/acsphyschemau.6c00045
Frontiers in aging neuroscience IF: 04.500Volume 18, Issue No.21Editorial: Understanding IGF-I's impact on neurocognitive aging: insights and therapeutic directions社论：理解IGF-I对神经认知衰老的影响：见解与治疗方向DOI: 10.3389/fnagi.2026.1973617
Frontiers in nutrition IF: 05.100Volume 13, Issue No.22Metabolomics profile in diabetes and blood glucose regulation: a systematic review糖尿病与血糖调控中的代谢组学特征：一项系统综述DOI: 10.3389/fnut.2026.1929989
In silico pharmacologyVolume 14, Issue 3No.23Integrated network pharmacology, molecular docking, ADMET profiling and In vitro α-amylase inhibitory evaluation of Cardiospermum halicacabum Linn. Against diabetes mellitus整合网络药理学、分子对接、ADMET预测及体外α-淀粉酶抑制评价Cardiospermum halicacabum Linn.抗糖尿病作用DOI: 10.1007/s40203-026-00756-8
Euroasian J HepatogastroenterolVolume 16, Issue 1No.24Glucagon-like Peptide-1 Receptor Agonists and Upper Gastrointestinal Endoscopy: A Narrative Review of Residual Gastric Contents Aspiration Risk and Periprocedural Management胰高血糖素样肽-1受体激动剂与上消化道内镜检查：残余胃内容物误吸风险及围手术期管理的叙述性综述DOI: 10.5005/jp-journals-10018-1502
Curēus IF: 01.300Volume 18, Issue 8No.25Association Between the Triglyceride-Glucose Index and Incident Cardiovascular Disease in Non-diabetic Adults: A Prospective Cohort Study甘油三酯-葡萄糖指数与非糖尿病成人新发心血管疾病的关联：一项前瞻性队列研究DOI: 10.7759/cureus.115208
In silico pharmacologyVolume 14, Issue 3No.26Abietic acid attenuates hyperglycemia and oxidative stress via TLR4-mediated inflammation and PPAR-γ-Nrf2 activation: evidence from network pharmacology and in vivo validation松香酸通过TLR4介导的炎症和PPAR-γ-Nrf2激活减轻高血糖和氧化应激：来自网络药理学和体内验证的证据DOI: 10.1007/s40203-026-00743-z
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.27Triglyceride-glucose index as a metabolic risk marker for adverse outcomes after coronary artery bypass grafting: a systematic review and meta-analysisDOI: 10.3389/fendo.2026.1909829
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.28Factors associated with sarcopenia in elderly patients with type 2 diabetes mellitusDOI: 10.3389/fendo.2026.1933664
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.29Repurposing a prostate tumor marker: elevated FPSA/TPSA ratio as a novel non-invasive biomarker for declining eGFR in male type 2 diabetesDOI: 10.3389/fendo.2026.1905743
J Trace Elem Med Biol IF: 03.300Ahead of Print.No.30Vanadium in environmental and biological systems: From industrial contaminant to insulin-mimetic agent环境与生物系统中的钒：从工业污染物到胰岛素模拟剂DOI: 10.1016/j.jtemb.2026.127965
Obes Res Clin Pract IF: 02.300Ahead of Print.No.31CNR2 inverse-agonist AM630 increases citrate synthase activity in the skeletal muscle of diet induced obese ratsCNR2反向激动剂AM630增加饮食诱导肥胖大鼠骨骼肌中的柠檬酸合酶活性DOI: 10.1016/j.orcp.2026.09.005
Kidney international IF: 12.600Ahead of Print.No.32Long-term outcomes of childhood nephrotic syndrome儿童肾病综合征的长期结局DOI: 10.1016/j.kint.2026.06.054
Clinical nutrition ESPEN IF: 02.600Ahead of Print.No.33Feasibility and clinical impact of a tailored nutritional protocol in pediatric elite athletes with Cerebral Palsy: a pilot study定制营养方案在脑瘫儿童精英运动员中的可行性及临床影响：一项初步研究DOI: 10.1016/j.clnesp.2026.105136
J Am Acad Dermatol IF: 11.800Ahead of Print.No.34Metabolic syndrome and early-onset androgenetic alopecia: A retrospective matched case-control study with a novel risk scoring system代谢综合征与早发性雄激素性脱发：一项采用新型风险评分系统的回顾性匹配病例对照研究DOI: 10.1016/j.jaad.2026.09.084
Clinical nutrition IF: 07.400Ahead of Print.No.35Creatine for glucagon-like peptide-1-associated muscle loss肌酸用于胰高血糖素样肽-1相关肌肉流失DOI: 10.1016/j.clnu.2026.106805
Immunobiology IF: 02.300Ahead of Print.No.36Impact of obesity on LAG-3 and CTLA-4 expression in CD4+ T cells from lymph nodes of sarcoidosis patients肥胖对结节病患者淋巴结CD4+ T细胞LAG-3和CTLA-4表达的影响DOI: 10.1016/j.imbio.2026.153248
Archives of medical research IF: 03.400Ahead of Print.No.37Developmental Origins of Health and Disease: The role of Clostridioides difficile Colonization of Gut Microbiota During Infancy健康与疾病的发育起源：婴儿期肠道微生物群中艰难梭菌定植的作用DOI: 10.1016/j.arcmed.2026.103526
Journal of robotic surgery IF: 03.000Volume 20, Issue 1No.38Robotic versus open (or laparoscopic) hysterectomy: a comprehensive review of clinical, surgical, and economic outcomes机器人对比开腹（或腹腔镜）子宫切除术：临床、手术及经济学结局的综合综述DOI: 10.1007/s11701-026-04002-3
Obesity surgery IF: 03.100Ahead of Print.No.39Crural Repair with or without Fundoplication During Sleeve Gastrectomy for Hiatal Hernia: Reflux Recurrence and Intrathoracic Migration at 18 Months袖状胃切除术中食管裂孔疝修补联合或不联合胃底折叠术：18个月反流复发与胸腔内迁移DOI: 10.1007/s11695-026-08958-x
Int Urogynecol J IF: 01.800Ahead of Print.No.40Impact of Surgical Weight Loss Interventions on Urinary Incontinence in Obese Women: Systematic Review and Meta-Analysis减重手术干预对肥胖女性尿失禁的影响：系统评价与荟萃分析DOI: 10.1007/s00192-026-06701-9
Cell biochemistry and function IF: 02.700Volume 44, Issue 9No.41Therapeutic Potential of Alkanna tinctoria Root in Ameliorating Obesity-Associated Hepatic, Adipose, and Reproductive Dysfunctions in Diet-Induced Obese ZebrafishAlkanna tinctoria根在改善饮食诱导肥胖斑马鱼中肥胖相关肝脏、脂肪和生殖功能障碍方面的治疗潜力DOI: 10.1002/cbf.70313
Rheumatology IF: 04.400Ahead of Print.No.42Obesity is more strongly associated with physical performance and body composition than sarcopenia in patients with spondyloarthritis在脊柱关节炎患者中，肥胖与体力表现和身体成分的关联比肌肉减少症更强DOI: 10.1093/rheumatology/keag530
Nephrol Dial Transplant IF: 05.600Ahead of Print.No.43Obesity and chronic kidney disease: a cardio-kidney-metabolic framework for renal vulnerability and risk stratification肥胖与慢性肾脏病：肾脏易感性和风险分层的CKM框架DOI: 10.1093/ndt/gfag221
J Multidiscip Healthc IF: 02.400Volume 19, Issue No.44Impact of Multimorbidity on Mental Illness in the United Arab Emirates: A Review多病共存对阿拉伯联合酋长国精神疾病的影响：一篇综述DOI: 10.2147/JMDH.S624773
Frontiers in nutrition IF: 05.100Volume 13, Issue No.45Gut dysbiosis induced by sunflower oil-based sucrose-free high-fat diet leads to steatohepatitis葵花籽油基无蔗糖高脂饮食诱导的肠道菌群失调导致脂肪性肝炎DOI: 10.3389/fnut.2026.1831803
Childhood obesity IF: 01.400Ahead of Print.No.46Interpreting Divergent Child Obesity Surveillance Signals During the COVID-19 Pandemic: Comparing Parent-Reported NSCH and Measured NHANES, United States, 2016-2023解读COVID-19大流行期间儿童肥胖监测信号的差异：比较家长报告的NSCH与实测的NHANES，美国，2016-2023年DOI: 10.1177/21532176261492812
Health affairs scholarVolume 4, Issue 9No.47Precision nutrition testing is the future of personalized care: evidence and coverage policies for equitable access精准营养检测是个性化医疗的未来：证据与覆盖政策促进公平可及DOI: 10.1093/haschl/qxag247
Health science reports IF: 02.100Volume 9, Issue 10No.48Knowledge, Practice, and Socio-Behavioral Determinants of Physical Activity Among Tunisian Medical Students: A Cross-Sectional Study突尼斯医学生体力活动的知识、实践及社会行为决定因素：一项横断面研究DOI: 10.1002/hsr2.73158
DUSUNEN ADAM IF: 00.400Volume 39, Issue 3No.49Peroneal neuropathy with foot drop after bariatric surgery: A neurosurgical perspective减重手术后腓神经病变伴足下垂：神经外科视角DOI: 10.14744/DAJPNS.2026.00337
Frontiers in sleepVolume 5, Issue No.50Physical exercise as a modulator of the sleep-obesity interaction: metabolic, neuroendocrine and circadian mechanisms体力活动作为睡眠-肥胖相互作用的调节因子：代谢、神经内分泌与昼夜节律机制DOI: 10.3389/frsle.2026.1943600
Obesity pillarsVolume 20, Issue No.51Investigating seizures in bariatric surgery patients: Pre- and postoperative perspectives: A systematic review减重手术患者癫痫发作的调查：术前与术后视角的系统综述DOI: 10.1016/j.obpill.2026.100326
Lancet Reg Health SEA IF: 06.200Volume 54, Issue No.52Iodine nutrition, thyroid function, and thyroid autoimmunity four decades after Universal Salt Iodisation in India: a cross-sectional study among schoolchildren (ICMR-SALT-T 1)印度实施全民食盐加碘四十年后的碘营养、甲状腺功能与甲状腺自身免疫：一项针对学龄儿童的横断面研究（ICMR-SALT-T 1）DOI: 10.1016/j.lansea.2026.100866
Gastroenterology report IF: 04.200Volume 14, Issue No.53Navigating TIPS in the era of ageing and metabolic comorbidity: a contemporary narrative review of risk, resilience, and outcomes在老龄化与代谢共病时代导航TIPS：关于风险、韧性与结局的当代叙述性综述DOI: 10.1093/gastro/goag103
Int J Eat Disord IF: 04.300Ahead of Print.No.54Examining Diagnostic Criteria for Atypical Anorexia Nervosa Post Metabolic Bariatric Surgery代谢减重手术后非典型神经性厌食症诊断标准的检验DOI: 10.1002/eat.70214
Euroasian J HepatogastroenterolVolume 16, Issue 1No.55Dapagliflozin in Metabolic Dysfunction-Associated Steatotic Liver Disease: Clinical Evidence and Therapeutic Potential达格列净在代谢功能障碍相关脂肪性肝病中的临床证据与治疗潜力DOI: 10.5005/jp-journals-10018-1501
Frontiers in nutrition IF: 05.100Volume 13, Issue No.56Prevalence and non-invasive predictive models of vitamin D insufficiency in Paraguayan youth: the role of body composition and traditional mate consumption巴拉圭青年维生素D不足的患病率及非侵入性预测模型：体成分与传统马黛茶消费的作用DOI: 10.3389/fnut.2026.1953400
J Formos Med Assoc IF: 02.500Ahead of Print.No.57Sudomotor dysfunction is associated with loss of residual renal function in patients undergoing peritoneal dialysis接受腹膜透析的患者中，泌汗功能障碍与残余肾功能丧失相关DOI: 10.1016/j.jfma.2026.09.031
Molecular metabolism IF: 06.600Ahead of Print.No.58Genetics of Type 2 Diabetes: beyond single nucleotide variant studies2型糖尿病的遗传学：超越单核苷酸变异研究DOI: 10.1016/j.molmet.2026.102449
JCMR IF: 06.100Ahead of Print.No.59Current Role and Future Utility of Cardiovascular Magnetic Resonance in the Assessment of Patients prior to and following Cardiac Transplantation - A narrative review心血管磁共振在心脏移植前后患者评估中的当前作用与未来应用——叙述性综述DOI: 10.1016/j.jocmr.2026.102804
Clinical nutrition ESPEN IF: 02.600Ahead of Print.No.60Residual Appendicular Lean Mass as a Marker of Metabolic Capacity: Association with Insulin Resistance in Korean Adults残余四肢瘦体重作为代谢能力标志物：与韩国成人胰岛素抵抗的关联DOI: 10.1016/j.clnesp.2026.105146
Annals of epidemiology IF: 03.000Ahead of Print.No.61Red Light, Green Light: Activity Fragmentation and All-Cause Mortality in United States Adults红灯、绿灯：美国成年人活动碎片化与全因死亡率DOI: 10.1016/j.annepidem.2026.110293
Regul Toxicol Pharmacol IF: 03.500Ahead of Print.No.62Suitability of the ICH S1B(R1) Weight-of-Evidence Framework to Evaluate Glucagon-Like Protein-1 Receptor Agonist (GLP-1RA) Carcinogenicity RiskICH S1B(R1) 证据权重框架评估胰高血糖素样肽-1受体激动剂致癌风险的适用性DOI: 10.1016/j.yrtph.2026.106252
Patient education and counseling IF: 03.100Ahead of Print.No.63Preference and participation in a randomized controlled trial of self-management support自我管理支持随机对照试验中的偏好与参与DOI: 10.1016/j.pec.2026.110314
Biochem Biophys Res Commun IF: 02.200Ahead of Print.No.64Combined exercise training and resveratrol supplementation modulate diabetes-related factors and mitochondrial biogenesis in male diabetic rats exposed to acute acoustic stress联合运动训练与白藜芦醇补充对暴露于急性声应激的雄性糖尿病大鼠糖尿病相关因子及线粒体生物发生的影响DOI: 10.1016/j.bbrc.2026.154635
Endocrinology IF: 03.300Ahead of Print.No.65miR-483 deficiency promotes loss of pancreatic beta-cell identity and aberrant glucagon production under metabolic stressmiR-483缺失在代谢应激下促进胰腺β细胞身份丢失和异常胰高血糖素产生DOI: 10.1210/endocr/bqag110
J Clin Endocrinol Metab IF: 05.100Ahead of Print.No.66Key Findings on the Efficacy and Safety of Testosterone Therapy from Two Large Randomized Trials两项大型随机试验关于睾酮治疗有效性与安全性的关键发现DOI: 10.1210/clinem/dgag397
Osteoporosis international IF: 05.400Ahead of Print.No.67Demographic and clinical differences between individuals with and without DXA scans in Denmark丹麦接受与未接受DXA扫描个体的人口学和临床差异DOI: 10.1007/s00198-026-08222-z
Obesity surgery IF: 03.100Ahead of Print.No.68Patient Perceptions and Barriers to Metabolic Bariatric Surgery Among Adults with Obesity in the West Bank, Palestine: A Cross-Sectional Study巴勒斯坦西岸地区肥胖成人对减重手术的认知与障碍：一项横断面研究DOI: 10.1007/s11695-026-08951-4
Gut microbes IF: 11.000Volume 18, Issue 1No.69Plasma indole-3-propionic acid is a gut-derived metabolite and is associated with type 2 diabetes and cardiometabolic outcomes: Evidence from a human antibiotic intervention血浆吲哚-3-丙酸是一种肠道来源代谢物，并与2型糖尿病及心血管代谢结局相关：来自人类抗生素干预的证据DOI: 10.1080/19490976.2026.2736321
Diabetologia IF: 10.200Ahead of Print.No.70The impact of physical activity and exercise timing on metabolic health among individuals at high risk of type 2 diabetes体力活动与运动时机对2型糖尿病高风险人群代谢健康的影响DOI: 10.1007/s00125-026-06871-7
J Biomater Sci Polym Ed IF: 03.600Ahead of Print.No.71MXene-based multifunctional wound dressings for diabetic wound healing: mechanisms, smart sensing, material integration and translational challenges基于MXene的多功能伤口敷料用于糖尿病伤口愈合：机制、智能传感、材料整合与转化挑战DOI: 10.1080/09205063.2026.2736164
JoVE IF: 01.000Volume 0, Issue 235No.72Treadmill Exercise is Associated with Intestinal Barrier and Cardiac Nlrp3 Gene Expression Changes in Diabetic Mice跑台运动与糖尿病小鼠肠道屏障及心脏Nlrp3基因表达变化相关DOI: 10.3791/73903
J Am Geriatr Soc IF: 04.500Ahead of Print.No.73All Hypoglycemia Is Not Created Equal所有低血糖并非生而平等DOI: 10.1111/jgs.70709
Andrology IF: 03.400Ahead of Print.No.74Cross-Sectional Study of the PREValence of Erectile DysfunctIon in the Arteriopathic Population (PREVEDI)动脉疾病人群中勃起功能障碍患病率的横断面研究（PREVEDI）DOI: 10.1111/andr.70406
Subst Use Addctn JAhead of Print.No.75Exploring Provider Knowledge and Attitudes Toward Opioid-Induced Androgen Deficiency Through the Lens of the Theory of Planned Behavior基于计划行为理论探索医疗服务提供者对阿片类药物诱导的雄激素缺乏的知识和态度DOI: 10.1177/29767342261469763
Curēus IF: 01.300Volume 18, Issue 8No.76Diabetic Autonomic Neuropathy Among Patients With Diabetes in Rural Warangal in India: A Cross-Sectional Study印度瓦朗加尔农村地区糖尿病患者中糖尿病自主神经病变的横断面研究DOI: 10.7759/cureus.115194
Case reports in endocrinology IF: 00.900Volume 2026, Issue No.77Recurrent Euglycemic Diabetic Ketoacidosis Weeks After SGLT2 Inhibitor Cessation: A Case ReportSGLT2抑制剂停药数周后复发性正常血糖糖尿病酮症酸中毒：一例病例报告DOI: 10.1155/crie/9610048
Curēus IF: 01.300Volume 18, Issue 8No.78Association of the Triglyceride-Glucose (TyG) Index With Biochemical Parameters in Acute Ischemic Stroke: A Cross-Sectional Study甘油三酯-葡萄糖指数与急性缺血性卒中生化参数的关联：一项横断面研究DOI: 10.7759/cureus.115247
RSC advances IF: 04.600Ahead of Print.No.79Metal-organic framework-based wearable electrochemical glucose sensors for sweat analysis: materials design, sensing mechanisms, and future perspectives基于金属有机框架的可穿戴电化学汗液葡萄糖传感器：材料设计、传感机制与未来展望DOI: 10.1039/d6ra06028e
Curēus IF: 01.300Volume 18, Issue 8No.80Persistent Neonatal Hypocalcemia as an Early Clue to TCIRG1-Related Infantile Osteopetrosis in an Infant of a Diabetic Mother: A Case Report持续性新生儿低钙血症作为糖尿病母亲婴儿中TCIRG1相关婴儿型骨硬化症的早期线索：一例病例报告DOI: 10.7759/cureus.115229
Health science reports IF: 02.100Volume 9, Issue 10No.81Molecular Epidemiology of TGF-β1 Gene Variants and Their Relationship With Adult Type 2 Diabetes Mellitus Patients Visiting Injibara Comprehensive Hospital in Northwest Ethiopia: A Case-Control StudyTGF-β1基因变异分子流行病学及其与埃塞俄比亚西北部Injibara综合医院成人2型糖尿病患者的关联：病例对照研究DOI: 10.1002/hsr2.73298
J Shoulder Elb ArthroplastVolume 10, Issue 4No.82Clinical and functional outcomes for bone tunnel vs. suture anchor lesser tuberosity osteotomy repair in total shoulder arthroplasty骨隧道与缝线锚钉在肩关节置换术中修复小结节截骨术的临床和功能结局比较DOI: 10.1016/j.jsea.2026.100072
Frontiers in medicine IF: 03.000Volume 13, Issue No.83From clinical records to community care: using real-world evidence in Ayurveda从临床记录到社区照护：在阿育吠陀中应用真实世界证据DOI: 10.3389/fmed.2026.1895750
JCEM case reportsVolume 4, Issue 11No.84Episodic hypercortisolemia-mediated periods of worsening hyperglycemia in cyclic Cushing syndrome周期性库欣综合征中发作性高皮质醇血症介导的血糖恶化期DOI: 10.1210/jcemcr/luag279
JCEM case reportsVolume 4, Issue 11No.85High metanephrines with adrenal hemorrhage: a diagnostic dilemma肾上腺出血伴甲氧基肾上腺素升高：诊断困境DOI: 10.1210/jcemcr/luag282
Glob Cardiol Sci PractVolume 2026, Issue 4No.86Sex-based differences in myocardial perfusion imaging among diabetic Egyptian patients:a retrospective registry study埃及糖尿病患者心肌灌注显像的性别差异：一项回顾性注册研究DOI: 10.21542/gcsp.2026.35
Frontiers in pharmacology IF: 04.800Volume 17, Issue No.87Impaired vascular function in gestational diabetes: evidence for metabolic memory, endothelial dysfunction and altered smooth muscle cell biology妊娠期糖尿病中的血管功能受损：代谢记忆、内皮功能障碍与平滑肌细胞生物学改变的证据DOI: 10.3389/fphar.2026.1907433
Glob Cardiol Sci PractVolume 2026, Issue 4No.88Seven-day mortality and its predictors among patients with acute coronary syndrome in southwestern Ethiopia: a prospective cohort study埃塞俄比亚西南部急性冠脉综合征患者七日死亡率及其预测因素：一项前瞻性队列研究DOI: 10.21542/gcsp.2026.32
Curēus IF: 01.300Volume 18, Issue 8No.89Serum Uric Acid Levels in the First Trimester of Pregnancy and the Development of Gestational Diabetes Mellitus: A Prospective Cohort Study妊娠早期血清尿酸水平与妊娠期糖尿病发生：一项前瞻性队列研究DOI: 10.7759/cureus.115200
Curēus IF: 01.300Volume 18, Issue 8No.90Iron Deficiency, Iron Deficiency Anemia, and HbA1c Levels in Nondiabetic Adults: A Systematic Review and Meta-Analysis非糖尿病成人中的铁缺乏、缺铁性贫血与HbA1c水平：系统综述与荟萃分析DOI: 10.7759/cureus.115191
Clinical case reports IF: 00.600Volume 14, Issue 10No.91Chronic Central Adrenal Insufficiency in a Patient With Remote Traumatic Brain Injury and an Apparently Adequate Standard-Dose ACTH Response: A Case Report陈旧性创伤性脑损伤患者标准剂量促肾上腺皮质激素反应看似充分却存在慢性中枢性肾上腺功能不全：一例病例报告DOI: 10.1002/ccr3.73582
Front Artif Intell IF: 04.700Volume 9, Issue No.92A two-stage deep learning framework with progressive feature fusion and attention mechanisms for multi-class retinal disease classification基于渐进式特征融合与注意力机制的两阶段深度学习框架用于多类视网膜疾病分类DOI: 10.3389/frai.2026.1925302
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.93γδ T-cell interferon-γ production reflects metabolic improvement during SGLT2 inhibitor-based therapy in type 2 diabetesγδ T细胞干扰素-γ产生反映2型糖尿病基于SGLT2抑制剂治疗期间的代谢改善DOI: 10.3389/fendo.2026.1922668
Internal and emergency medicine IF: 03.800Ahead of Print.No.94Oral semaglutide vs DPP-4 inhibitors in reducing risk of cognitive impairment in elderly patients with HFpEF and obesity口服司美格鲁肽与DPP-4抑制剂在降低老年射血分数保留的心力衰竭合并肥胖患者认知障碍风险中的比较DOI: 10.1007/s11739-026-04539-z
EJPC IF: 07.500Ahead of Print.No.95Long-term Trends in Upper Gastrointestinal Bleeding and Ischemic Outcomes after Myocardial Infarction心肌梗死后上消化道出血与缺血结局的长期趋势DOI: 10.1093/eurjpc/zwag508
EJPC IF: 07.500Ahead of Print.No.96When Wearables See What We Cannot: Are Athletes’ Heart Rate Monitors Becoming Arrhythmia Surveillance Tools?当可穿戴设备看到我们无法看到的东西：运动员的心率监测器正在成为心律失常监测工具吗？DOI: 10.1093/eurjpc/zwag454
GLIA IF: 05.100Volume 74, Issue 12No.97Interleukin-17A Links Obesity-Induced Inflammation to Behavioral Disorders and Autonomic Imbalance白细胞介素-17A将肥胖诱导的炎症与行为障碍和自主神经失衡联系起来DOI: 10.1002/glia.70237
Annals of African medicine IF: 00.600Ahead of Print.No.98Clinical Correlation between Screening Test STOP-BANG Score and Body Mass Index with Obstructive Sleep Apnea Severity in Patients with Sleep-disordered Breathing筛查测试STOP-BANG评分和体重指数与睡眠呼吸障碍患者阻塞性睡眠呼吸暂停严重程度的临床相关性DOI: 10.4103/aam.aam_352_26
Veterinary sciences IF: 02.300Volume 13, Issue 9No.99Functional Classification of Tropical Cattle Feeding Systems Reveals Consistent Associations with Dairy Lipid Quality, Enteric Methane Emissions, and Preclinical Metabolic Outcomes: A Multi-Study Narrative Synthesis热带牛饲养系统的功能分类揭示与乳脂质量、肠道甲烷排放及临床前代谢结局的稳定关联：一项多研究叙述性综合DOI: 10.3390/vetsci13090988
Viruses IF: 03.500Volume 18, Issue 9No.100Eating Habits and Possible Effects of Mediterranean Diet on Body Composition in Ageing People Living with HIV in Two Italian Centres两个意大利中心老年HIV感染者的饮食习惯及地中海饮食对身体成分的可能影响DOI: 10.3390/v18090931
Pharmaceuticals IF: 04.800Volume 19, Issue 9No.101Aqueous Extract of Buddleja globosa Modulates Oxidative Stress-Induced Senescence-Associated Responses in THP-1-Derived MacrophagesBuddleja globosa水提物调节THP-1衍生巨噬细胞中氧化应激诱导的衰老相关反应DOI: 10.3390/ph19091447
Pharmaceutics IF: 05.500Volume 18, Issue 9No.102Calcifediol Treatment Improves Skin Wound Healing in Vitamin D Deficiency Obese Rats骨化二醇治疗改善维生素D缺乏肥胖大鼠的皮肤伤口愈合DOI: 10.3390/pharmaceutics18091175
Nutrients IF: 05.000Volume 18, Issue 18No.103Associations Between Maternal and Cord Blood Leptin Levels and Anthropometry of Mothers and Infants母体与脐血瘦素水平及母婴人体测量学指标的关联DOI: 10.3390/nu18183105
Nutrients IF: 05.000Volume 18, Issue 18No.104Vitamin D Status in Polish Military Personnel: Associations with Supplementation, Seasonality, and the GC rs2282679 Polymorphism波兰军人维生素D状况：与补充、季节性和GC rs2282679基因多态性的关联DOI: 10.3390/nu18183041
Nutrients IF: 05.000Volume 18, Issue 18No.105Revealing Hidden Patterns: Harnessing Correspondence Analysis to Explore Maternal Lifestyle Profiles and Gestational Weight Gain揭示隐藏模式：利用对应分析探索母亲生活方式特征与妊娠期体重增加DOI: 10.3390/nu18183038
Nutrients IF: 05.000Volume 18, Issue 18No.106Sex-Dependent Lipidomic Remodeling in Plasma and Feces Following High-Fat Diet Intake in Adult Rats成年大鼠摄入高脂饮食后血浆和粪便中性别依赖的脂质组重塑DOI: 10.3390/nu18183014
Nutrients IF: 05.000Volume 18, Issue 18No.107Therapeutic Potential of Berberine in Obesity-Associated Neuroinflammation Through Shared Molecular Pathways: TLR4/NF-κB/MAPK, ROS/NRF2 and NLRP3小檗碱通过共享分子通路TLR4/NF-κB/MAPK、ROS/NRF2和NLRP3治疗肥胖相关神经炎症的潜力DOI: 10.3390/nu18183000
Nutrients IF: 05.000Volume 18, Issue 18No.108Biochemical-Anthropometric Indices Assessing Liver Steatosis Identified in Elastography in Children with Metabolic DysFunction-Associated Steatotic Liver Disease在代谢功能障碍相关脂肪性肝病儿童中评估弹性成像所识别肝脏脂肪变性的生化-人体测量指标DOI: 10.3390/nu18182996
Nutrients IF: 05.000Volume 18, Issue 18No.109The NUTRI-OBEDIGITHUM Pathway: Integrating Personalized Exchange-Based Nutrition into Digitally Enabled Obesity Care and a Retrospective Real-World Cohort AnalysisNUTRI-OBEDIGITHUM路径：将个性化基于交换的膳食营养整合到数字化肥胖照护中及一项回顾性真实世界队列分析DOI: 10.3390/nu18182985
Nutrients IF: 05.000Volume 18, Issue 18No.110A Food-Based Sequential KETOgenic Nutritional Protocol for Mediterranean Diet Non-Responders with COMPlicated Obesity: A Real-World Observational Study (KETOCOMP)针对地中海饮食无应答的复杂肥胖患者的食物为基础序贯生酮营养方案：一项真实世界观察性研究（KETOCOMP）DOI: 10.3390/nu18182982
Nutrients IF: 05.000Volume 18, Issue 18No.111Dietary Matcha Attenuates High-Fat High-Sugar Diet-Induced Cardiomyocyte Hypertrophy in Association with Gut Microbiota Remodeling in Mice膳食抹茶通过重塑小鼠肠道菌群减轻高脂高糖饮食诱导的心肌细胞肥大DOI: 10.3390/nu18182961
Nutrients IF: 05.000Volume 18, Issue 18No.112Accumulation and Time-Dependent Changes in Unfavorable Eating Behaviors and the Risk of Incident Metabolic Dysfunction-Associated and Alcohol-Related/Associated Steatotic Liver Disease: A Retrospective Cohort Study不良饮食行为的累积和时间依赖性变化与代谢功能障碍相关及酒精相关/伴随脂肪性肝病发病风险：一项回顾性队列研究DOI: 10.3390/nu18182957
Nutrients IF: 05.000Volume 18, Issue 18No.113Interactions Between Genetic Risk and Macronutrient Intake on Obesity-Related Traits in Sri Lankan Adults遗传风险与宏量营养素摄入对斯里兰卡成年人肥胖相关特征的交互作用DOI: 10.3390/nu18182951
Nutrients IF: 05.000Volume 18, Issue 18No.114Weight Gain During SSRI Therapy: The Potential Role of the Gut Microbiota-A Narrative Review and Mechanistic Hypothesis选择性5-羟色胺再摄取抑制剂治疗期间的体重增加：肠道微生物群的潜在作用——叙述性综述与机制假说DOI: 10.3390/nu18182940
Medicina IF: 02.400Volume 62, Issue 9No.115Fall-Related Physical Function, Executive Function, and Myokine Responses in Older Women with Obesity Participating in a 16-Week Combined Aquatic Exercise Program: A Prospective Observational Study参与16周联合水中运动项目的肥胖老年女性跌倒相关身体机能、执行功能与肌因子反应：一项前瞻性观察性研究DOI: 10.3390/medicina62091667
Medicina IF: 02.400Volume 62, Issue 9No.116Effect of Pressure-Controlled Versus Volume-Controlled Ventilation on Gastric Insufflation During i-gel Use in Adults: A Randomised Controlled Trial压力控制通气与容量控制通气对成人i-gel使用期间胃充气的影响：一项随机对照试验DOI: 10.3390/medicina62091657
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.117Relationship Between Cognitive Performance and Anthropometric Status, Dietary Diversity, and Diet Quality in Older Turkish Adults: A Cross-Sectional Study土耳其老年人认知表现与人体测量状况、膳食多样性和饮食质量之间的关系：一项横断面研究DOI: 10.3390/jcm15187280
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.118Radiographic Changes in Patellar Height Following Rapid Weight Loss After Sleeve Gastrectomy: A Retrospective Observational Study袖状胃切除术后快速减重导致髌骨高度影像学变化：一项回顾性观察性研究DOI: 10.3390/jcm15187137
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.119Temporal Patterns of Body Composition After Heart and Lung Transplantation Assessed by Bioelectrical Impedance Analysis通过生物电阻抗分析评估心脏和肺移植后身体成分的时间模式DOI: 10.3390/jcm15187034
Microorganisms IF: 04.200Volume 14, Issue 9No.120Dietary Fructose and Early-Onset Colorectal Cancer: Metabolic, Microbial, and Translational Perspectives膳食果糖与早发性结直肠癌：代谢、微生物及转化视角DOI: 10.3390/microorganisms14092046
Life IF: 03.400Volume 16, Issue 9No.121Autophagy and Mitophagy in Hypertensive Chronic Kidney Disease: Evidence Grading, Cell-Type Divergence, and a Working Lysosomal Hypothesis高血压慢性肾脏病中的自噬与线粒体自噬：证据分级、细胞类型差异及一个工作性溶酶体假说DOI: 10.3390/life16091481
Life IF: 03.400Volume 16, Issue 9No.122Bile Microbiota Profiling in Obese and Non-Obese Patients: A Comparison of Shotgun Metagenomics and 16S rRNA Amplicon Sequencing肥胖与非肥胖患者胆汁微生物群分析：鸟枪法宏基因组学与16S rRNA扩增子测序的比较DOI: 10.3390/life16091474
Life IF: 03.400Volume 16, Issue 9No.123Sex Differences, Depressive Symptoms, and Early Blood Pressure Control After Hospital Discharge in Cardiovascular Patients: A Prospective Observational Single-Center Study性别差异、抑郁症状与心血管患者出院后早期血压控制：一项前瞻性观察性单中心研究DOI: 10.3390/life16091454
Life IF: 03.400Volume 16, Issue 9No.124The Probiotic Strain Hafnia Alvei HA4597 and Its Protein Extract Selectively Activate Membrane Digestive Enzymes of Intestinal Cells in Mice益生菌株Hafnia alvei HA4597及其蛋白提取物选择性激活小鼠肠道细胞膜消化酶DOI: 10.3390/life16091445
Life IF: 03.400Volume 16, Issue 9No.125Critical Care Management of Severe Acute Pancreatitis: Current Concepts, Clinical Challenges, and Future Perspectives重症急性胰腺炎的危重症管理：当前概念、临床挑战与未来展望DOI: 10.3390/life16091407
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.126The Wound-Heart Axis: Can Chronic Wounds Contribute to Cardiac Dysfunction?伤口-心脏轴：慢性伤口是否会导致心脏功能障碍？DOI: 10.3390/ijms27188138
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.127Targeted 3.34-Million CpG Site Sequencing Reveals Preliminary Cord Blood Epigenetic Alterations of Autism Spectrum Disorder: A Pilot Study Highlighting the PCDHA1-PCDHA8 Cluster靶向334万CpG位点测序揭示自闭症谱系障碍的脐血表观遗传初步改变：一项突出PCDHA1-PCDHA8基因簇的初步研究DOI: 10.3390/ijms27188038
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.128BMAL1 Dysregulation as a Contributing Mechanism Linking Obesity to Oocyte and Endometrial Dysfunction in IVFBMAL1失调作为连接肥胖与体外受精中卵母细胞及子宫内膜功能障碍的贡献机制DOI: 10.3390/ijms27188001
Children IF: 02.100Volume 13, Issue 9No.129Motor Competence in Greek Adolescents Using Movement Assessment Battery for Children-2nd Edition: Associations with Individual and Environmental Factors使用儿童运动评估成套工具第二版评估希腊青少年的运动能力：与个体及环境因素的关联DOI: 10.3390/children13091260
Children IF: 02.100Volume 13, Issue 9No.130Outcome of Targeted Therapy for Obstructive Sleep Apnea in Children with Obesity and Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)靶向治疗对肥胖合并代谢功能障碍相关脂肪性肝病儿童阻塞性睡眠呼吸暂停的结局DOI: 10.3390/children13091241
Children IF: 02.100Volume 13, Issue 9No.131Actual Body Weight and the Parent's Perspective of Child's Body Weight Among Canadian First Nations Children加拿大第一民族儿童的实际体重与家长对儿童体重的认知DOI: 10.3390/children13091197
Children IF: 02.100Volume 13, Issue 9No.132Associations Between 24-Hour Movement Behaviors and Anthropometric and Body Composition Indicators in Ecuadorian Preschool Children: SUNRISE Pilot Study厄瓜多尔学龄前儿童24小时运动行为与人体测量及身体成分指标的关联：SUNRISE试点研究DOI: 10.3390/children13091129
Foods IF: 05.100Volume 15, Issue 18No.133Unraveling the Food Matrix Components Underlying Glycemic Response in Yellow Popcorn Hybrids (Zea mays var. 'Everta')解析黄色爆裂玉米杂交种（Zea mays var. 'Everta'）血糖反应背后的食物基质组分DOI: 10.3390/foods15183333
Foods IF: 05.100Volume 15, Issue 18No.134Urinary Hypaphorine as a Candidate Marker of FFQ-Derived Legume Intake Within the EAT-Lancet Framework in Free-Living Adults尿液中Hypaphorine作为自由生活成人EAT-Lancet框架下FFQ来源豆类摄入的候选标志物DOI: 10.3390/foods15183279
Diagnostics IF: 03.300Volume 16, Issue 18No.135CT Attenuation Thresholds for Grading Hepatic Steatosis in Adults with Overweight or Obesity and Metabolic Dysfunction-Associated Steatotic Liver Disease用于对超重或肥胖成人及代谢功能障碍相关脂肪性肝病患者脂肪性肝病分级的CT衰减阈值DOI: 10.3390/diagnostics16182996
Healthcare IF: 02.700Volume 14, Issue 18No.136Changes in Body Composition and Sexual Satisfaction Following Metabolic and Bariatric Surgery in Women with Obesity: A Prospective Study肥胖女性减重手术后身体成分与性满意度的变化：一项前瞻性研究DOI: 10.3390/healthcare14182954
Biomedicines IF: 03.900Volume 14, Issue 9No.137Genetic Assessment of Oesophageal Safety of GLP-1 and GIP Receptor Perturbation: A Drug-Target Mendelian Randomisation StudyGLP-1和GIP受体扰动食管安全性的遗传学评估：一项药物靶点孟德尔随机化研究DOI: 10.3390/biomedicines14091887
Biology IF: 03.500Volume 15, Issue 18No.138Associations Between FTO (Fat Mass- and Obesity-Associated) Gene Allelic Load and Heart Rate Responses to Submaximal Exercise in Humans: A Cross-Sectional StudyFTO（脂肪量和肥胖相关）基因等位基因负荷与人类次极量运动心率反应的关联：一项横断面研究DOI: 10.3390/biology15181607
Behavioral sciences IF: 02.500Volume 16, Issue 9No.139Therapists' and Researchers' Perspectives on a Transdiagnostic Ecological Momentary Intervention "EmoGuia" for Emotional Disorders: A Consensual Qualitative Study治疗师和研究人员对针对情绪障碍的跨诊断生态瞬时干预“EmoGuia”的看法：一项共识质性研究DOI: 10.3390/bs16091546
Antioxidants IF: 06.600Volume 15, Issue 9No.140Urinary Extracellular Vesicle-Derived miRNAs Reveal a Coordinated Stress-Response Network Linked to Advanced Glycation End-Products in Children and Adolescents尿液细胞外囊泡来源的miRNA揭示与儿童和青少年晚期糖基化终产物相关的协调应激反应网络DOI: 10.3390/antiox15091150
Antioxidants IF: 06.600Volume 15, Issue 9No.141Phytochemicals and Irisin as Multi-Target Regulators of Adipose Tissue Browning and Metabolic Reprogramming: Synergies with GLP-1 Pathways植物化学物与鸢尾素作为脂肪组织棕色化和代谢重编程的多靶点调节因子：与GLP-1通路的协同作用DOI: 10.3390/antiox15091143
J Occup Med Toxicol IF: 02.700Volume 21, Issue 1No.142Sedentary behavior and activity patterns in Swedish log truck drivers - a descriptive cross-sectional study瑞典原木卡车司机的久坐行为与体力活动模式——一项描述性横断面研究DOI: 10.1186/s12995-026-00531-7
Front Clin Diabetes Healthc IF: 02.200Volume 7, Issue No.143Fetal behavior as a window to later gross motor function: a 10-year follow-up of children prenatally exposed to gestational diabetes mellitus胎儿行为作为后续大肌肉运动功能的窗口：产前暴露于妊娠期糖尿病儿童的10年随访研究DOI: 10.3389/fcdhc.2026.1938676
Healthcare IF: 02.700Volume 14, Issue 18No.144Association Between E-Health Literacy and OGTT Status at Study Enrollment Among Pregnant Women孕妇入组时电子健康素养与口服葡萄糖耐量试验状态之间的关联DOI: 10.3390/healthcare14183026
Frontiers in public health IF: 03.400Volume 14, Issue No.145Misconceptions and health-seeking behavior among diabetic patients regarding foot ulcers: the hidden role of circulatory awareness in preventing amputation糖尿病患者对足部溃疡的误解与就医行为：循环意识在预防截肢中的隐藏作用DOI: 10.3389/fpubh.2026.1924054
Front Sports Act Living IF: 02.600Volume 8, Issue No.146Impact of a 2-year structured program on physical fitness and physical activity in T2D patients with rapid renal function decline-the ACTIDIANE RCT为期2年的结构化项目对肾功能快速下降的2型糖尿病患者身体机能和体力活动的影响——ACTIDIANE随机对照试验DOI: 10.3389/fspor.2026.1892496
Journal of internal medicine IF: 09.200Ahead of Print.No.147Vascular Ehlers-Danlos syndrome: A multidisciplinary clinical framework for early suspicion, emergency-safe management and lifelong care血管型Ehlers-Danlos综合征：早期怀疑、急诊安全管理和终身护理的多学科临床框架DOI: 10.1111/joim.70165
Medicine IF: 01.400Volume 105, Issue 39No.148Concomitant limaprost use and intraocular pressure response to latanoprost in normal-tension glaucoma: A retrospective cohort study正常眼压性青光眼中联合使用利马前列素与拉坦前列素对眼压反应的影响：一项回顾性队列研究DOI: 10.1097/MD.0000000000050838
Viruses IF: 03.500Volume 18, Issue 9No.149Epstein-Barr Virus: More than Just an InfectionEpstein-Barr病毒：不仅仅是感染DOI: 10.3390/v18091048
Toxics IF: 04.100Volume 14, Issue 9No.150The Impact of Polycyclic Aromatic Hydrocarbons Exposure from Seasonal Biomass Burning on Oxidative Stress and Genotoxicity Biomarkers in Patients with Diabetes and Hypertension in Chiang Mai, Thailand泰国清迈季节性生物质燃烧多环芳烃暴露对糖尿病和高血压患者氧化应激及遗传毒性生物标志物的影响DOI: 10.3390/toxics14090771
Toxics IF: 04.100Volume 14, Issue 9No.151Heavy Metal Contamination in Commercial Coffee Products in Saudi Arabia: Prevalence, Carcinogenic and Non-Carcinogenic Risk Assessment, and Implications for Diabetes and Cardiovascular Disease沙特阿拉伯商业咖啡产品中的重金属污染：流行率、致癌和非致癌风险评估及其对糖尿病和心血管疾病的影响DOI: 10.3390/toxics14090761
Vaccines IF: 03.400Volume 14, Issue 9No.152Metabolic Signatures Associated with COVID-19 Vaccination in Serum from Healthy Individuals健康个体血清中与COVID-19疫苗接种相关的代谢特征DOI: 10.3390/vaccines14090771
Pharmaceuticals IF: 04.800Volume 19, Issue 9No.153Preclinical Efficacy of Recombinant Human Platelet-Derived Growth Factor-BB in Experimental Diabetic Wound Healing: A Systematic Review and Meta-Analysis of Animal Studies重组人血小板衍生生长因子-BB在实验性糖尿病创面愈合中的临床前有效性：动物研究的系统评价与荟萃分析DOI: 10.3390/ph19091497
Pharmaceuticals IF: 04.800Volume 19, Issue 9No.154Treatment-Emergent Epiretinal Membrane in Diabetic Macular Edema: A Real-World OCT-Based Comparative Pharmacotherapy Study Across Intravitreal Agents-The TRIDENT-DME Study糖尿病性黄斑水肿中治疗中出现视网膜前膜：一项基于真实世界OCT的玻璃体腔注射药物比较药物治疗研究——TRIDENT-DME研究DOI: 10.3390/ph19091390
Pharmaceutics IF: 05.500Volume 18, Issue 9No.155Development and Characterization of a Hydrogel Incorporating Protamine-Hyaluronic Acid Nanoparticles Co-Loaded with Disulfiram and Coumarin for Diabetic Wound Healing用于糖尿病伤口愈合的共载双硫仑和香豆素的鱼精蛋白-透明质酸纳米粒水凝胶的开发和表征DOI: 10.3390/pharmaceutics18091180
Pharmaceutics IF: 05.500Volume 18, Issue 9No.156Drug-Loaded Red Blood Cell-Derived Carriers for Targeted Delivery to Accelerate Tissue Regeneration载药红细胞衍生载体用于靶向递送以加速组织再生DOI: 10.3390/pharmaceutics18091131
Pharmaceutics IF: 05.500Volume 18, Issue 9No.157CNP-miR146a Promotes NRF2-Related Ferroptosis-Protective Myeloid Programs and Immune-Vascular Regeneration in Diabetic WoundsCNP-miR146a促进糖尿病创面中NRF2相关的铁死亡保护性髓系程序及免疫血管再生DOI: 10.3390/pharmaceutics18091116
Pharmaceutics IF: 05.500Volume 18, Issue 9No.158Microfluidic Production of Dexamethasone-Loaded PLGA Microparticles: Dynamic Solvent Extraction Improves Process Robustness During the Droplet-to-Particle Transition微流控制备地塞米松负载PLGA微颗粒：动态溶剂萃取提高液滴向颗粒转变过程中的工艺稳健性DOI: 10.3390/pharmaceutics18091075
Nutrients IF: 05.000Volume 18, Issue 18No.159Primary Hyperparathyroidism in Celiac Disease: Diagnostic Challenges and Therapeutic Strategies乳糜泻中的原发性甲状旁腺功能亢进症：诊断挑战与治疗策略DOI: 10.3390/nu18183107
Nutrients IF: 05.000Volume 18, Issue 18No.160Refeeding the Gut in Anorexia Nervosa: Microbiome, Nutritional Rehabilitation and Dietetic Care神经性厌食症中的肠道再喂养：微生物组、营养康复与饮食护理DOI: 10.3390/nu18183054
Nutrients IF: 05.000Volume 18, Issue 18No.161Elevated White Blood Cell Counts Despite Normal C-Reactive Protein Independently Predict Metabolic Syndrome and Myocardial Infarction: Evidence for Genetic Susceptibility and Dietary Modification in a Prospective Cohort白细胞计数升高而C反应蛋白正常可独立预测代谢综合征和心肌梗死：前瞻性队列中遗传易感性和饮食调整的证据DOI: 10.3390/nu18183040
Nutrients IF: 05.000Volume 18, Issue 18No.162Associations Between Chocolate Consumption and Cardiometabolic Risk Markers Across Metabolic Profiles: Insights from a Population-Based Study巧克力摄入与心血管代谢风险标志物的关联因代谢特征而异：一项基于人群研究的启示DOI: 10.3390/nu18183023
Nutrients IF: 05.000Volume 18, Issue 18No.163Gaultheria Berries as Potential Functional Foods: Phytochemical Composition, Health-Promoting Properties, and Nutritional Potential白珠树浆果作为潜在功能性食品：植物化学成分、健康促进特性与营养潜力DOI: 10.3390/nu18183015
Nutrients IF: 05.000Volume 18, Issue 18No.164Retinal and Choroidal Vascular Changes Associated with Vitamin D Deficiency维生素D缺乏相关的视网膜和脉络膜血管变化DOI: 10.3390/nu18183006
Nutrients IF: 05.000Volume 18, Issue 18No.165Enhanced Metabolic Risks in Patients with Obesity and Nutritional Deficiencies in the U.S.: A TriNetX Study美国肥胖合并营养缺乏患者的代谢风险增加：一项TriNetX研究DOI: 10.3390/nu18183005
Nutrients IF: 05.000Volume 18, Issue 18No.166Dietary Bioactive Compounds: Cellular Sensory Pathways, Microbial Partners, and Clinical Realities膳食生物活性化合物：细胞感知通路、微生物伙伴与临床现实DOI: 10.3390/nu18183001
Nutrients IF: 05.000Volume 18, Issue 18No.167Clinical Translation of Fisetin for Age-Related Diseases: Current Evidence and Future Opportunities非瑟酮用于年龄相关疾病的临床转化：当前证据与未来机遇DOI: 10.3390/nu18182999
Nutrients IF: 05.000Volume 18, Issue 18No.168Foods as Modulators of GLP-1 Secretion食物作为GLP-1分泌的调节剂DOI: 10.3390/nu18182995
Nutrients IF: 05.000Volume 18, Issue 18No.169Preconception and Early-Pregnancy Alcohol Consumption in Women and Men, Infertility and Risk for Miscarriage女性和男性孕前及孕早期饮酒与不孕及流产风险DOI: 10.3390/nu18182953
Nutrients IF: 05.000Volume 18, Issue 18No.170Effects of Chokeberry Juice Added to a Mediterranean-Style Diet on Glycemic Control and Redox Homeostasis in Women with Prediabetes: A Randomized Controlled Trial在地中海式饮食中添加野樱莓汁对糖尿病前期女性血糖控制和氧化还原稳态的影响：一项随机对照试验DOI: 10.3390/nu18182948
Nutrients IF: 05.000Volume 18, Issue 18No.171Mediterranean Diet and Global Dietary Shifts, 1990-2018: Population-Level Analysis Using Global Dietary Database地中海饮食与1990-2018年全球饮食变迁：基于全球饮食数据库的人群水平分析DOI: 10.3390/nu18182943
Pathogens IF: 03.300Volume 15, Issue 9No.172Comparing Self-Administered Outpatient Parenteral Antimicrobial Therapy (S-OPAT) with Alternative Delivery Models: Risk Factors for Treatment Failure and Complications in a UK Cohort比较自我管理门诊肠外抗菌治疗（S-OPAT）与替代给药模式：英国队列中治疗失败和并发症的风险因素DOI: 10.3390/pathogens15090981
Pathogens IF: 03.300Volume 15, Issue 9No.173Diabetes Mellitus Affects Urinary Tissue Tropism of Group B Streptococci in a Sex-Dependent Manner糖尿病以性别依赖的方式影响B族链球菌的泌尿组织嗜性DOI: 10.3390/pathogens15090923
Pathogens IF: 03.300Volume 15, Issue 9No.174Epidemiology, Diagnostics and Therapy of Vulvovaginal Fungal Infections外阴阴道真菌感染的流行病学、诊断与治疗DOI: 10.3390/pathogens15090914
Molecules IF: 04.600Volume 31, Issue 18No.175Searching for Metabolic Markers for Hypertension in Human Urine在人类尿液中寻找高血压的代谢标志物DOI: 10.3390/molecules31183349
Molecules IF: 04.600Volume 31, Issue 18No.176Evaluation of the Potential Hypoglycemic and Neuroprotective Effects of Rosehip Fruit玫瑰果潜在降血糖和神经保护作用的评估DOI: 10.3390/molecules31183343
Molecules IF: 04.600Volume 31, Issue 18No.177Metabolomics-Based Identification of α-Glucosidase Inhibitors from Pometia pinnata Stem Bark Using LC-HRMS and Molecular Docking基于代谢组学的Pometia pinnata茎皮α-葡萄糖苷酶抑制剂鉴定：LC-HRMS与分子对接研究DOI: 10.3390/molecules31183233
Molecules IF: 04.600Volume 31, Issue 18No.178Comparative Analysis of Selected Biochemical Markers Involved in Antioxidative, Immune Responses, and Thyroid Function in Wistar Rats Fed Diets Containing Baked Sprats含烤制西鲱饲料对Wistar大鼠抗氧化、免疫反应及甲状腺功能相关生化标志物的比较分析DOI: 10.3390/molecules31183169
Molecules IF: 04.600Volume 31, Issue 18No.179Synthesis and Antidiabetic Evaluation of Novel 2,4-Thiazolidinedione Derivatives Targeting Key Carbohydrate-Digesting Enzymes靶向关键碳水化合物消化酶的新型2,4-噻唑烷二酮衍生物的合成及抗糖尿病评价DOI: 10.3390/molecules31183160
Medicina IF: 02.400Volume 62, Issue 9No.180Behavioral and Psychosocial Effects of Participant-Visible Continuous Glucose Monitoring in Adults Without Diabetes: A Systematic Review参与者可见的连续血糖监测对无糖尿病成人的行为和心理社会影响：一项系统评价DOI: 10.3390/medicina62091814
Medicina IF: 02.400Volume 62, Issue 9No.181Key Inflammatory Pathways, Biomarkers, and Targeted Management Strategies in Primary Total Joint Arthroplasty: A Narrative Review初次全关节置换术中的关键炎症通路、生物标志物及靶向管理策略：叙述性综述DOI: 10.3390/medicina62091713
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.182Resting Heart Rate Association with Cardiovascular Morbidity and Mortality and All-Cause Mortality According to Cluster of Cardiovascular Risk Factors-A Prospective Cohort Study with More than 20 Years of Follow-Up静息心率与心血管疾病发病率和死亡率及全因死亡率的关联：基于心血管危险因素聚类的前瞻性队列研究，随访超过20年DOI: 10.3390/jcm15187333
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.183A Retrospective Analysis of Inhaled Nitric Oxide and Outcomes in Mechanically Ventilated Patients with COVID-19 ARDS吸入一氧化氮与COVID-19 ARDS机械通气患者结局的回顾性分析DOI: 10.3390/jcm15187302
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.184One-Year Evolution of Macrovascular and Microvascular Parameters After Endovascular Revascularization in Diabetic Foot Ulcers: A Prospective Multicenter Study糖尿病足溃疡血管内血运重建后大血管和微血管参数的一年演变：一项前瞻性多中心研究DOI: 10.3390/jcm15187278
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.185Effects of High-Intensity Interval Versus Moderate-Intensity Continuous Training in Adults with Prediabetes: A Single-Blind Randomized Controlled Trial高强度间歇训练与中等强度持续训练对糖尿病前期成人的效果：一项单盲随机对照试验DOI: 10.3390/jcm15187277
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.186Functional Outcomes of a Complex Rehabilitation Program in Children with Spastic Diplegic Cerebral Palsy: A Prospective Observational Study痉挛型双瘫脑瘫儿童综合康复方案的功能结局：一项前瞻性观察性研究DOI: 10.3390/jcm15187092
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.187Association of Real-Time Glucose Levels and Cognitive Performance in Children with Type 1 Diabetes: A Cross-Sectional Study1型糖尿病儿童实时血糖水平与认知表现的关联：一项横断面研究DOI: 10.3390/jcm15187080
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.188Exploratory Evaluation of Quantitative Rubidium-82 PET Myocardial Perfusion Parameters: Absolute Blood Flow, Flow Reserve, and Left Ventricular Function in an Arabian Gulf Cohort阿拉伯湾队列中定量铷-82 PET心肌灌注参数的探索性评估：绝对血流量、血流储备和左心室功能DOI: 10.3390/jcm15187059
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.189Population-Level Heterogeneity in People with Obesity: A Cross-Sectional Cluster Analysis of a Population-Based Registry肥胖人群的群体水平异质性：一项基于人群注册数据库的横断面聚类分析DOI: 10.3390/jcm15187026
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.190Outcomes of Kissing Stent Technique for the Endovascular Treatment of Aorto-Iliac TASC C/D Lesions对吻支架技术用于主髂动脉TASC C/D病变腔内治疗的结果DOI: 10.3390/jcm15187007
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.191Clinical and Epidemiological Characteristics of Retrospective Single-Center Observational Study回顾性单中心观察研究的临床与流行病学特征DOI: 10.3390/jcm15186960
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.192From Trials to Treatment: Current Evidence Supporting Faricimab Use in nAMD and DME从试验到治疗：支持法瑞西单抗用于新生血管性年龄相关性黄斑变性和糖尿病性黄斑水肿的当前证据DOI: 10.3390/jcm15186956
Microorganisms IF: 04.200Volume 14, Issue 9No.193Causes of Bacterial Infections and Antibiotic Resistance Profiles in Patients with Chronic Wounds慢性伤口患者细菌感染病因及抗生素耐药谱分析DOI: 10.3390/microorganisms14091978
Microorganisms IF: 04.200Volume 14, Issue 9No.194Epidemic Years Increase Hospitalization but Not Mortality Among Laboratory-Confirmed Dengue Cases in Mexico: A Nationwide Surveillance Study, 2020-2025流行年份增加墨西哥实验室确诊登革热病例的住院率但不增加死亡率：2020-2025年全国监测研究DOI: 10.3390/microorganisms14091920
Life IF: 03.400Volume 16, Issue 9No.195Combined Mesenchymal Stem Cells and Low-Energy Shock Wave Therapy Significantly Reduced Inflammation, Oxidative Stress and Preserved Podocytes in Diabetic Nephropathy间充质干细胞联合低能量冲击波治疗显著减轻糖尿病肾病炎症、氧化应激并保护足细胞DOI: 10.3390/life16091550
Life IF: 03.400Volume 16, Issue 9No.196Low Ankle-Brachial Index in Patients on Hemodialysis Is Associated with Elevated Serum Levels of Spermine Oxidase and C-Reactive Protein血液透析患者低踝臂指数与血清精胺氧化酶和C反应蛋白水平升高相关DOI: 10.3390/life16091521
Life IF: 03.400Volume 16, Issue 9No.197Single Autoantibody Positivity in Pediatric Type 1 Diabetes: Serological Profiles, Clinical Trajectories and Implications for Early Disease Monitoring-A Case Series of Seven Patients儿童1型糖尿病中单一自身抗体阳性：血清学特征、临床轨迹及对早期疾病监测的意义——七例病例系列DOI: 10.3390/life16091500
Life IF: 03.400Volume 16, Issue 9No.198Clinical Reference Values for Dynamic Plantar Pressure Assessment in Healthy Young Adults: Sex Differences and Bilateral Symmetry健康年轻成人动态足底压力评估的临床参考值：性别差异与双侧对称性DOI: 10.3390/life16091449
Life IF: 03.400Volume 16, Issue 9No.199Dieterich Disease: Avascular Necrosis of the Third Metacarpal Head in an AdultDieterich病：成人第三掌骨头缺血性坏死DOI: 10.3390/life16091440
Life IF: 03.400Volume 16, Issue 9No.200N-Acetylcysteine as a Bacterial Antibiofilm Adjuvant: Mechanisms, Synergistic Combinations and Clinical TranslationN-乙酰半胱氨酸作为细菌抗生物膜佐剂：机制、协同组合与临床转化DOI: 10.3390/life16091414
Life IF: 03.400Volume 16, Issue 9No.201Non-Arteritic Anterior Ischemic Optic Neuropathy (NA-AION) and High-Risk Cardiovascular Events非动脉炎性前部缺血性视神经病变（NA-AION）与高风险心血管事件DOI: 10.3390/life16091401
Cancers IF: 04.400Volume 18, Issue 18No.202Accelerated Pancreatic Volume Loss as a Potential Pre-Diagnostic Imaging Biomarker for Pancreatic Cancer Risk Enrichment: An AI-Assisted Volumetric Study加速的胰腺体积损失作为胰腺癌风险富集的潜在诊断前影像学生物标志物：一项AI辅助的体积研究DOI: 10.3390/cancers18183062
Cancers IF: 04.400Volume 18, Issue 18No.203Diabetes Trajectory and Pancreatic Cancer Detection in Patients with Diabetes: A Nationwide Survey Through Japan Diabetes Society-Certified Facilities糖尿病患者中的糖尿病轨迹与胰腺癌检测：通过日本糖尿病学会认证机构的全国性调查DOI: 10.3390/cancers18182995
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.204Correction: Hwang et al. IFN-β Overexpressing Adipose-Derived Mesenchymal Stem Cells Mitigate Alcohol-Induced Liver Damage and Gut Permeability. Int. J. Mol. Sci. 2024, 25, 8509更正：Hwang等人。过表达IFN-β的脂肪间充质干细胞减轻酒精诱导的肝损伤和肠道通透性。Int. J. Mol. Sci. 2024, 25, 8509DOI: 10.3390/ijms27188423
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.205High Glucose Induces Biomolecular Dysregulation in Primary Human Corneal Epithelial Cells: Potential Biomarkers of Hyperglycemia-Driven Corneal Impairment高糖诱导原代人角膜上皮细胞生物分子失调：高血糖驱动角膜损伤的潜在生物标志物DOI: 10.3390/ijms27188406
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.206Fractional Subnanosecond Nd:YAG Laser Improves Matrix Architecture in Ultraviolet-Aged Facial Retaining Ligaments in Rats分次亚纳秒Nd:YAG激光改善紫外线老化大鼠面部支持韧带的基质结构DOI: 10.3390/ijms27188371
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.207Bloodstream Infection After Major Burn Surgery in Relation to Preoperative Glycemic Gap Among Patients Without Diabetes: A Retrospective Cohort Study非糖尿病患者大面积烧伤手术后血流感染与术前血糖间隙的关系：一项回顾性队列研究DOI: 10.3390/ijms27188137
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.208High Glucose Alters Extracellular Vesicle Protein Composition and Promotes EV-Mediated Monocyte Adhesion to Endothelial Cells高糖改变细胞外囊泡蛋白组成并促进EV介导的单核细胞与内皮细胞黏附DOI: 10.3390/ijms27188107
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.209Next-Generation GLP-1 Agonist Bioassays: Integrating Precision with Biological Relevance下一代GLP-1激动剂生物测定：整合精准性与生物学相关性DOI: 10.3390/ijms27188068
Children IF: 02.100Volume 13, Issue 9No.210Family Impact, Caregiver Burden, Parental Monitoring, and Glycemic Control in Children with Type 1 Diabetes: A Cross-Sectional Study1型糖尿病患儿的家庭影响、照顾者负担、父母监测与血糖控制：一项横断面研究DOI: 10.3390/children13091253
Children IF: 02.100Volume 13, Issue 9No.211Mapping Randomized Controlled Trials of Family- and Community-Centered Healthcare Interventions for Pediatric Asthma, Type 1 Diabetes, or Juvenile Idiopathic Arthritis-A Scoping Review针对儿童哮喘、1型糖尿病或幼年特发性关节炎的家庭与社区中心医疗干预随机对照试验的映射——一项范围综述DOI: 10.3390/children13091232
Diagnostics IF: 03.300Volume 16, Issue 18No.212Monckeberg's Medial Sclerosis in Athletes: Report of Two Cases and Possible Pathophysiological Mechanisms运动员中的Monckeberg中膜硬化：两例报告及可能的病理生理机制DOI: 10.3390/diagnostics16183064
Diagnostics IF: 03.300Volume 16, Issue 18No.213Diagnostic Reassessment of a Pulmonary Mass Initially Suspected to Represent IgG4-Related Lung Disease: The Complementary Role of Tissue Metagenomic Sequencing对最初怀疑为IgG4相关性肺病的肺部肿块的诊断再评估：组织宏基因组测序的补充作用DOI: 10.3390/diagnostics16183018
Diagnostics IF: 03.300Volume 16, Issue 18No.214Longitudinal Changes in Ganglion Cell Complex Thickness Before and After Intravitreal Bevacizumab Injections in Diabetic Macular Edema糖尿病性黄斑水肿玻璃体腔注射贝伐珠单抗前后神经节细胞复合体厚度的纵向变化DOI: 10.3390/diagnostics16182892
Healthcare IF: 02.700Volume 14, Issue 18No.215Preventive Care for Non-Communicable Diseases in Greece: A Situational Analysis of Disease Burden, Service Delivery, Financing, Screening and Quality Governance希腊非传染性疾病预防保健：疾病负担、服务提供、筹资、筛查与质量治理的情境分析DOI: 10.3390/healthcare14183116
Healthcare IF: 02.700Volume 14, Issue 18No.216Patient-Centered Diabetes Care Through an Ethical Lens: Associations with Patient Satisfaction and Patient-Reported Outcomes in Saudi Primary Healthcare伦理视角下的以患者为中心的糖尿病照护：与沙特初级医疗中患者满意度和患者报告结局的关联DOI: 10.3390/healthcare14183098
Healthcare IF: 02.700Volume 14, Issue 18No.217Explainable AI for Digital Health: Predicting Depression Risk in Older Adults Living Alone Using Machine Learning可解释人工智能在数字健康中的应用：利用机器学习预测独居老年人抑郁风险DOI: 10.3390/healthcare14183088
Healthcare IF: 02.700Volume 14, Issue 18No.218Effect of Nursing Intervention Supported by Mobile Health Applications on Asthma Control, Maternal and Neonatal Outcomes Among Pregnant Women with Asthma移动健康应用支持的护理干预对哮喘孕妇哮喘控制及母婴结局的影响DOI: 10.3390/healthcare14183079
Healthcare IF: 02.700Volume 14, Issue 18No.219Nonfatal Burden of Disease and Risk-Attributable Burden in Romania, 1990 to 2023: A Secondary Analysis of Global Burden of Disease 2023 Estimates1990年至2023年罗马尼亚非致命疾病负担与风险归因负担：全球疾病负担2023估计的二次分析DOI: 10.3390/healthcare14183035
Curr Issues Mol Biol IF: 03.000Volume 48, Issue 9No.220Transcriptomic and Zonal Signatures of Mitochondrial Peroxisomal Dysfunction in HCV Associates with Circulating Mitochondrial DNA BiomarkersHCV中线粒体过氧化物酶体功能障碍的转录组和分区特征与循环线粒体DNA生物标志物相关DOI: 10.3390/cimb48090877
Curr Issues Mol Biol IF: 03.000Volume 48, Issue 9No.221Comparative Evaluation of Traditional and Emerging Glycemic Biomarkers in Diabetes糖尿病中传统与新兴血糖生物标志物的比较评估DOI: 10.3390/cimb48090866
Nutrients IF: 05.000Volume 18, Issue 18No.222Barriers and Enablers Influencing Dietetic Practice in the Management of Polyendocrine Metabolic Ovarian Syndrome影响多内分泌代谢性卵巢综合征管理中饮食实践的因素：障碍与促进因素DOI: 10.3390/nu18183010
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.223Syringic Acid in Health and Disease: Mechanisms, Biological Activities, and Future Perspectives丁香酸在健康与疾病中的作用：机制、生物活性及未来展望DOI: 10.3390/ijms27188385
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.224The Triglyceride-Glucose Index and Its Combination with C-Reactive Protein and Anthropometric Indicators as Biomarkers for Hypertension Among Saudi Adults: A Cross-Sectional Survey甘油三酯-葡萄糖指数及其与C反应蛋白和人体测量指标联合作为沙特成年人高血压生物标志物的横断面调查DOI: 10.3390/jcm15187253
Diagnostics IF: 03.300Volume 16, Issue 18No.225Screening Signals of Reference-Defined Metabolic Syndrome Using HbA1c and LDL Cholesterol: An Explainable Machine Learning Study使用糖化血红蛋白和低密度脂蛋白胆固醇筛查参考定义代谢综合征的信号：一项可解释机器学习研究DOI: 10.3390/diagnostics16183048
Biomedicines IF: 03.900Volume 14, Issue 9No.226Associations of General and Central Obesity with Cardiovascular Risk by Menopausal and MASLD Status全身性肥胖与中心性肥胖和心血管风险的关联：按绝经状态和MASLD状态分层DOI: 10.3390/biomedicines14091985
Pharmaceuticals IF: 04.800Volume 19, Issue 9No.227Comparative Evaluation of Drug Incorporation and Release Profiles in Six Specific Porous Vaterite CaCO3 Formulations六种特定多孔球霰石碳酸钙制剂中药物装载与释放特性的比较评价DOI: 10.3390/ph19091446
Pharmaceutics IF: 05.500Volume 18, Issue 9No.228Non-Systemic Oral Cellulose-Based Superabsorbent Hydrogels for Weight Management: Potential Drug-Device Interactions Estimated by a Simplified In Vitro Assay用于体重管理的非系统性口服纤维素基超吸水水凝胶：通过简化体外试验评估潜在的药物-器械相互作用DOI: 10.3390/pharmaceutics18091173
Pharmaceutics IF: 05.500Volume 18, Issue 9No.229Novel Bioequivalent Sitagliptin and Metformin Bilayer Tablet with Improved Chemical Stability新型生物等效的西格列汀和二甲双胍双层片具有改善的化学稳定性DOI: 10.3390/pharmaceutics18091066
Nutrients IF: 05.000Volume 18, Issue 18No.230Ellagic Acid and Metformin: In Vitro Synergy and Enhanced Cisplatin Efficacy In Vivo in Resistant Breast Cancer鞣花酸与二甲双胍：体外协同作用及体内增强顺铂对耐药乳腺癌的疗效DOI: 10.3390/nu18183047
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.231Phosphoproteomic Insights into TRPV4-AMPK Signaling Axis and Barrier Regulation in the Choroid Plexus Epithelium磷酸化蛋白质组学揭示脉络丛上皮中TRPV4-AMPK信号轴与屏障调控机制DOI: 10.3390/ijms27188305
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.232Acquired BRAFi Resistance Increases Melanoma Cell Sensitivity to Metabolic Targeting with Metformin获得性BRAFi耐药性增加黑色素瘤细胞对二甲双胍代谢靶向的敏感性DOI: 10.3390/ijms27188088
Curr Issues Mol Biol IF: 03.000Volume 48, Issue 9No.233Metformin Attenuates the High-Glucose Effect on MORG1 Expression in HEK293 Cells二甲双胍减弱高糖对HEK293细胞中MORG1表达的影响DOI: 10.3390/cimb48090934
Genes IF: 02.800Volume 17, Issue 9No.234Genetic Variants Involved in Metformin Pharmacokinetics in the Chilean Population智利人群中参与二甲双胍药代动力学的遗传变异DOI: 10.3390/genes17091114
Biomedicines IF: 03.900Volume 14, Issue 9No.235Differential Effects of Carboplatin, Metformin, and Boric Acid on Cell Viability, Migration, and Oxidative Stress in MCF-7 Breast Cancer and CRL-4010 Normal Mammary Epithelial Cells卡铂、二甲双胍和硼酸对MCF-7乳腺癌细胞和CRL-4010正常乳腺上皮细胞在细胞活力、迁移和氧化应激方面的差异效应DOI: 10.3390/biomedicines14092073
Biomedicines IF: 03.900Volume 14, Issue 9No.236Potential Role of the Triple Receptor Agonist Retatrutide in Antipsychotic-Associated Metabolic Dysfunction Among Clozapine- and Olanzapine-Treated Schizophrenia Spectrum Disorders: A Narrative Review and Theoretical Framework三重受体激动剂瑞他鲁肽在氯氮平和奥氮平治疗的精神分裂症谱系障碍中抗精神病药相关代谢功能障碍的潜在作用：叙述性综述和理论框架DOI: 10.3390/biomedicines14091957
Biomedicines IF: 03.900Volume 14, Issue 9No.237Drug-Induced Reduction in 80Q Aggregates in a Dictyostelium discoideum Model of PolyQ Disease药物诱导减少PolyQ疾病盘基网柄菌模型中的80Q聚集体DOI: 10.3390/biomedicines14091931
Pharmaceuticals IF: 04.800Volume 19, Issue 9No.238Orlistat-Associated Gastrointestinal, Hepatobiliary, Pancreatic, and Anorectal Safety Signals: A FAERS Disproportionality and Regulatory Label Concordance Study奥利司他相关的胃肠、肝胆、胰腺和肛门直肠安全信号：一项FAERS比例失衡分析与监管标签一致性研究DOI: 10.3390/ph19091325
Pharmaceuticals IF: 04.800Volume 19, Issue 9No.239Oxidative Stress as a Pathophysiological Core of Obesity: Preclinical Evidence for Antioxidant-Based Therapy Strategies氧化应激作为肥胖的病理生理核心：基于抗氧化治疗策略的临床前证据DOI: 10.3390/ph19091414
Cancers IF: 04.400Volume 18, Issue 18No.240Altered Lipolytic Protein Expression in Tumor-Associated Adipose Tissue Correlates with Aggressive Breast Cancer Features肿瘤相关脂肪组织中脂解蛋白表达改变与侵袭性乳腺癌特征相关DOI: 10.3390/cancers18183001
Nutrients IF: 05.000Volume 18, Issue 18No.241Energy Drink Use and Adolescent Sleep Debt: Implications for Obesity, Cognition, and Physical Activity能量饮料使用与青少年睡眠债：对肥胖、认知和体力活动的影响DOI: 10.3390/nu18182946
Medicina IF: 02.400Volume 62, Issue 9No.242Clinical and Biomechanical Predictors of Forefoot Plantar Pressure in Individuals with Type 2 Diabetes and Peripheral Neuropathy2型糖尿病合并周围神经病变患者前足压力的临床与生物力学预测因素DOI: 10.3390/medicina62091701
Advanced healthcare materials IF: 09.600Ahead of Print.No.243Ultrasound-Mediated CRISPR Delivery and Sonogenetic Modulation for Precision Therapeutics超声介导的CRISPR递送与声遗传学调控用于精准治疗DOI: 10.1002/adhm.71753
Molecules IF: 04.600Volume 31, Issue 18No.244Cell Reporter-Based Analysis of Anti-Inflammasome Activities of Flavonoids with Distinct Structures基于细胞报告基因分析不同结构黄酮类化合物的抗炎性小体活性DOI: 10.3390/molecules31183176
Medicina IF: 02.400Volume 62, Issue 9No.245Current Diabetes Self-Management and the Number of Documented Complications in Adults with Type 2 Diabetes: A Cross-Sectional Study成人2型糖尿病患者当前糖尿病自我管理与记录并发症数量的横断面研究DOI: 10.3390/medicina62091777
Antioxidants IF: 06.600Volume 15, Issue 9No.246Antioxidants as a Link Between Diabetes and Potential Plant-Based Therapies抗氧化剂作为糖尿病与潜在植物疗法之间的纽带DOI: 10.3390/antiox15091206
Bioengineering IF: 03.700Volume 13, Issue 9No.247Feasibility Study on Non-Invasive Methods for Bladder Biomechanics During Voiding Using Uro-Dynamic MRI使用尿动力学MRI无创评估排尿期膀胱生物力学的可行性研究DOI: 10.3390/bioengineering13091007
Pharmaceuticals IF: 04.800Volume 19, Issue 9No.248Untargeted Metabolomic and Phytochemical Profiling of Berberis crataegina DC. Plant Parts: Antidiabetic Potential and Cytoprotection in High-Glucose-Exposed SH-SY5Y CellsBerberis crataegina DC.植物部位的非靶向代谢组学与植物化学分析：抗糖尿病潜力及高糖暴露SH-SY5Y细胞中的细胞保护作用DOI: 10.3390/ph19091365
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.249Modeling Diabetic Neuropathy: Injury Biomarkers for Early Detection Through Neuronal and Glial In Vitro Models糖尿病神经病变建模：通过神经元和胶质细胞体外模型进行早期检测的损伤生物标志物DOI: 10.3390/ijms27188234
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.250Multivariate Genome-Wide Association Analysis Identifies Genetic Susceptibility Loci for Metabolic Syndrome in the Korean Genome and Epidemiology Study多变量全基因组关联分析在韩国基因组与流行病学研究中识别代谢综合征的遗传易感位点DOI: 10.3390/ijms27188041
Healthcare IF: 02.700Volume 14, Issue 18No.251Factors Associated with Hospital Length of Stay After Coronary Artery Bypass Grafting: Perioperative Characteristics and Postoperative Complication Burden冠状动脉旁路移植术后住院时间相关因素：围手术期特征与术后并发症负担DOI: 10.3390/healthcare14182968
Children IF: 02.100Volume 13, Issue 9No.252Evaluation of Grazing Behavior and Its Associations with Obesity, Emotion Regulation Difficulties, and Problematic Smartphone Use in Adolescents with Essential Hypertension青少年原发性高血压患者进食行为及其与肥胖、情绪调节困难和问题性智能手机使用的关系评估DOI: 10.3390/children13091233
Life IF: 03.400Volume 16, Issue 9No.253Genetic Variants Associated with Response to GLP-1 Receptor Agonists in Diabetes and Obesity糖尿病和肥胖中与胰高血糖素样肽-1受体激动剂反应相关的遗传变异DOI: 10.3390/life16091486
Medicina IF: 02.400Volume 62, Issue 9No.254Intralesional Epidermal Growth Factor and Its Association with Reamputation and Level-Up Amputation in Diabetic Foot Patients with Post-Amputation Flap Necrosis: Clinical Outcomes and Macrophage Dynamics病灶内表皮生长因子与糖尿病足截肢后皮瓣坏死患者再截肢及高位截肢的关联：临床结局与巨噬细胞动态DOI: 10.3390/medicina62091800
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.255Antimicrobial Peptides for Diabetic Foot Ulcers and Infections: Current Evidence and Translational Perspectives抗菌肽用于糖尿病足溃疡与感染：当前证据与转化前景DOI: 10.3390/ijms27188035
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.256A Military Veteran with Pulmonary Fibrosis, Hepatic Cirrhosis, Bone Marrow Dysfunction and Shortened Telomeres Found to Have GAVE, a Potential Unsuspected Consequence of Telomere Spectrum Disorder一名患有肺纤维化、肝硬化、骨髓功能障碍和端粒缩短的退伍军人被发现患有GAVE，可能是端粒谱系疾病的一种潜在未预料后果DOI: 10.3390/jcm15187073
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.257Early Lean Tissue Loss and Nutritional Challenges Following Sleeve Gastrectomy in a Kidney Transplant Recipient: A Case Report肾移植受者袖状胃切除术后早期瘦组织丢失与营养挑战：一例病例报告DOI: 10.3390/jcm15186940
Curr Issues Mol Biol IF: 03.000Volume 48, Issue 9No.258Molecular Distinctions, Diagnosis, and Mechanism-Based Therapies in Lipedema and Obesity脂肪水肿与肥胖的分子差异、诊断及基于机制的疗法DOI: 10.3390/cimb48090892
Bioengineering IF: 03.700Volume 13, Issue 9No.259Stable Constitutive BiP Expression Prolongs Late-Stage GLP-1-Fc Accumulation in CHO Cells稳定组成型BiP表达延长CHO细胞中GLP-1-Fc的晚期积累DOI: 10.3390/bioengineering13091001
Pharmaceutics IF: 05.500Volume 18, Issue 9No.260Salcaprozate Sodium as a Permeation Enhancer-Mechanism, Applications and Unresolved Questions沙卡普拉扎钠作为渗透促进剂——机制、应用与未解问题DOI: 10.3390/pharmaceutics18091171
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.261GLP-1 Receptor Agonists in Epilepsy: Separating Evidence for Antiseizure Activity, Neuroprotection, and Disease ModificationGLP-1受体激动剂在癫痫中的应用：区分抗癫痫发作活性、神经保护与疾病修饰的证据DOI: 10.3390/ijms27188036
Biomedicines IF: 03.900Volume 14, Issue 9No.262Semaglutide Attenuates Inflammatory Macrophage Polarization and Promotes Changes Associated with Mitochondrial Biogenesis Through cAMP-Dependent Signaling司美格鲁肽通过cAMP依赖性信号通路减弱炎症性巨噬细胞极化并促进与线粒体生物发生相关的变化DOI: 10.3390/biomedicines14091987
Life IF: 03.400Volume 16, Issue 9No.263Environmental Exposures and Epigenetic Remodeling in Supraventricular Tachycardias: What Atrial Fibrillation Can and Cannot Tell Us室上性心动过速中的环境暴露与表观遗传重塑：心房颤动能告诉我们什么，不能告诉我们什么DOI: 10.3390/life16091506
Pharmaceuticals IF: 04.800Volume 19, Issue 9No.264Reduction of Microglial Reactivity by Cannabidiol: Preliminary Data Obtained in an Astrocyte-Microglia Co-Culture Model of Inflammation大麻二酚降低小胶质细胞反应性：在星形胶质细胞-小胶质细胞炎症共培养模型中获得的初步数据DOI: 10.3390/ph19091342
Pharmaceuticals IF: 04.800Volume 19, Issue 9No.265Precision Pharmacotherapy for Obstructive Sleep Apnea: Matching Targeted Drugs to Patient Endophenotypes阻塞性睡眠呼吸暂停的精准药物治疗：将靶向药物与患者内表型相匹配DOI: 10.3390/ph19091361
Medicina IF: 02.400Volume 62, Issue 9No.266Digital Engagement Phenotypes and 6-Month Weight Loss in a Tirzepatide-Supported Digital Weight-Loss Program: A Retrospective Cohort Study替尔泊肽支持的数字减重项目中数字参与表型与6个月体重减轻：一项回顾性队列研究DOI: 10.3390/medicina62091647
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.267GLP-1 Receptor Agonists and Tirzepatide in Men Seeking Fertility: A Structured Narrative Review and Proposed Clinical Framework胰高血糖素样肽-1受体激动剂与替尔泊肽在寻求生育的男性中的应用：结构化叙述性综述及拟议临床框架DOI: 10.3390/jcm15187313
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.268Visceral Adiposity and Renal Health: From Pathophysiological Mechanisms to Novel Therapeutic Strategies内脏肥胖与肾脏健康：从病理生理机制到新型治疗策略DOI: 10.3390/jcm15187201
Brain sciences IF: 02.800Volume 16, Issue 9No.269Neuropsychiatric Outcomes Associated with GLP-1 Receptor Agonists in Adults with Overweight or Obesity: A Systematic Review超重或肥胖成人使用GLP-1受体激动剂相关的神经精神结局：一项系统综述DOI: 10.3390/brainsci16090926
Healthcare IF: 02.700Volume 14, Issue 18No.270Association Between Psychological Distress and Glycaemic Control Among Adults with Diabetes Mellitus in Saudi Arabia沙特阿拉伯成人糖尿病患者心理困扰与血糖控制之间的关联DOI: 10.3390/healthcare14182978
Biomedicines IF: 03.900Volume 14, Issue 9No.271Abdominal Obesity, Testosterone Deficiency and Sedentary Lifestyle in Young Men from the General Population: The Relationship with Semen Quality, Hormonal and Metabolic Status一般人群中年轻男性的腹型肥胖、睾酮缺乏与久坐生活方式：与精液质量、激素及代谢状态的关系DOI: 10.3390/biomedicines14092097
Plants IF: 04.100Volume 15, Issue 18No.272Tessaria absinthioides (Hook. & Arn.) DC. (Asteraceae) Decoction vs. Metformin: Effects on Glucose Homeostasis and Behavior Under Chronic Sucrose ExposureTessaria absinthioides (Hook. & Arn.) DC.（菊科）煎剂与二甲双胍对比：慢性蔗糖暴露下对葡萄糖稳态和行为的影响DOI: 10.3390/plants15182872
FCVM IF: 02.900Volume 13, Issue No.273Real-world safety and clinical outcomes of apixaban in patients with cancer and atrial fibrillation阿哌沙班在癌症合并心房颤动患者中的真实世界安全性与临床结局DOI: 10.3389/fcvm.2026.1893856
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.274Temporal Trends in Anticoagulant Prescribing in Patients with Atrial Fibrillation According to Prior Ischemic Stroke or Transient Ischemic Attack: Insights from the CRAFT Registry根据既往缺血性卒中或短暂性脑缺血发作分析心房颤动患者抗凝药物处方的时序趋势：来自CRAFT注册研究的见解DOI: 10.3390/jcm15187242
Nutrients IF: 05.000Volume 18, Issue 18No.275Targeting the Gut-Bone Axis with Prebiotics, Probiotics, Synbiotics, and Postbiotics: From Mechanistic Plausibility to Clinical Bone Outcomes靶向肠-骨轴：益生元、益生菌、合生元和后生元从机制合理性到临床骨骼结局DOI: 10.3390/nu18182967
Nutrients IF: 05.000Volume 18, Issue 18No.276Dietary Fiber Supplementation Reduces Systolic Blood Pressure in High-Risk Patients with Type 2 Diabetes and Hypertension: A Secondary Analysis of a Randomized Trial膳食纤维补充降低2型糖尿病合并高血压高风险患者的收缩压：一项随机试验的二次分析DOI: 10.3390/nu18182945
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.277Neurovascular Unit Dysfunction and Neural Barrier Pathology in Dysautonomia: Molecular Links to Cardiovascular Autonomic Failure神经血管单元功能障碍与自主神经功能障碍中的神经屏障病理：与心血管自主神经衰竭的分子联系DOI: 10.3390/ijms27188375
Pharmaceutics IF: 05.500Volume 18, Issue 9No.278Beyond Anti-VEGF: Toward Integrated Precision Care in Diabetic Retinal Disease超越抗VEGF：迈向糖尿病视网膜疾病的整合精准医疗DOI: 10.3390/pharmaceutics18091178
Life IF: 03.400Volume 16, Issue 9No.279Effects of Curcumin on Inflammation in a Rat Model of Diabetic Retinopathy姜黄素对糖尿病视网膜病变大鼠模型炎症的影响DOI: 10.3390/life16091427
Diagnostics IF: 03.300Volume 16, Issue 18No.280Cardiovascular Disease Risk Assessment from Retinal Fundus Images Using a CSP-ConvNext Model基于CSP-ConvNext模型的视网膜眼底图像心血管疾病风险评估DOI: 10.3390/diagnostics16183058
Healthcare IF: 02.700Volume 14, Issue 18No.281Clinical, Socioeconomic, and Demographic Factors Associated with Diabetic Retinopathy in a Hospital-Based Screening Program: A Cross-Sectional Study in Oslo, Norway挪威奥斯陆一项医院筛查项目中与糖尿病视网膜病变相关的临床、社会经济和人口学因素：一项横断面研究DOI: 10.3390/healthcare14182929
Biomolecules IF: 04.800Volume 16, Issue 9No.282Proteomic Analysis of Retinas from Two Different Type-1 Diabetic Models两种不同1型糖尿病模型视网膜的蛋白质组学分析DOI: 10.3390/biom16091314
Biomedicines IF: 03.900Volume 14, Issue 9No.283Glutathione-Related Responses to Hyperglycemic and Hyperosmotic Stress in Cultured Human Retinal Pericytes and Endothelial Cells: An Exploratory Study培养的人视网膜周细胞和内皮细胞对高血糖和高渗应激的谷胱甘肽相关反应：一项探索性研究DOI: 10.3390/biomedicines14092104
Biology IF: 03.500Volume 15, Issue 18No.284Compartment-Specific Immune, Endothelial, and Fibrotic Programs in Diabetic Retinopathy: An Integrative Multi-Cohort Transcriptomic Study糖尿病视网膜病变中区室特异性免疫、内皮和纤维化程序：一项整合多队列转录组研究DOI: 10.3390/biology15181581
Antioxidants IF: 06.600Volume 15, Issue 9No.285Metabolic Dysregulation and Oxidative Stress in Diabetic Retinopathy: Glycogen Metabolism, Mitochondrial Dysfunction, and Antioxidant Defences糖尿病视网膜病变中的代谢失调与氧化应激：糖原代谢、线粒体功能障碍和抗氧化防御DOI: 10.3390/antiox15091093
BMC ophthalmology IF: 01.700Volume 26, Issue 1No.286Preoperative OCT biomarkers and surgical outcomes after vitrectomy with epiretinal membrane and internal limiting membrane peeling for refractory diabetic macular edema: a retrospective cohort study难治性糖尿病性黄斑水肿玻璃体切除术联合视网膜前膜和内界膜剥除的术前OCT生物标志物与手术结局：一项回顾性队列研究DOI: 10.1186/s12886-026-05352-0
Eye IF: 03.200Ahead of Print.No.287Phosphodiesterase 5 inhibitor use and incident diabetic retinopathy in men with erectile dysfunction and type 2 diabetes: a propensity-matched cohort study磷酸二酯酶5抑制剂使用与勃起功能障碍合并2型糖尿病男性糖尿病视网膜病变发病的关系：一项倾向性匹配队列研究DOI: 10.1038/s41433-026-04893-4
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.288Treatment Patterns, Disease Management, and Quality of Life in Outpatients with CKD and Decreased eGFR: A Multicenter Prospective Observational Study in Greece慢性肾脏病合并估算肾小球滤过率下降门诊患者的治疗模式、疾病管理与生活质量：希腊多中心前瞻性观察性研究DOI: 10.3390/jcm15187244
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.289Body Mass Index and LDL Cholesterol Across Controls, Hypertension, and Ischemic Heart Disease with Preserved Ejection Fraction: A Single-Center Retrospective Cross-Sectional Study体重指数与低密度脂蛋白胆固醇在对照组、高血压及射血分数保留的缺血性心脏病中的比较：一项单中心回顾性横断面研究DOI: 10.3390/jcm15187096
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.290Statins and Myasthenia Gravis: Clinical Implications and Pathogenesis他汀类药物与重症肌无力：临床意义与发病机制DOI: 10.3390/ijms27188150
Curr Issues Mol Biol IF: 03.000Volume 48, Issue 9No.291The Role of 5-HT1A and 5-HT7 Receptors in Anxiety-like Behavior in Mice Treated with Subchronic Atorvastatin5-HT1A和5-HT7受体在亚慢性阿托伐他汀治疗小鼠焦虑样行为中的作用DOI: 10.3390/cimb48090962
Biomedicines IF: 03.900Volume 14, Issue 9No.292Association Between the Triglyceride-to-HDL Cholesterol Ratio and Glycemic Control in Patients with Type 2 Diabetes Mellitus: A Real-World Retrospective Study甘油三酯与高密度脂蛋白胆固醇比值与2型糖尿病患者血糖控制之间的关联：一项真实世界回顾性研究DOI: 10.3390/biomedicines14091995
Nutrients IF: 05.000Volume 18, Issue 18No.293Baseline Ferritin and Body Composition as Correlates of Longitudinal Metabolic Changes During an Energy-Restricted Mediterranean-Style Intervention Across Three Overweight Phlogistic-Related Clinical Conditions基线铁蛋白与身体成分作为三种超重炎症相关临床状况下能量限制地中海式干预期间纵向代谢变化的相关因素DOI: 10.3390/nu18183044
Pathogens IF: 03.300Volume 15, Issue 9No.294Microbiological Evaluation of Upper Respiratory Tract Specimens in Patients with Plaque Psoriasis and Psoriatic Arthritis: A Retrospective Study斑块状银屑病及银屑病关节炎患者上呼吸道标本的微生物学评估：一项回顾性研究DOI: 10.3390/pathogens15090967
Pathogens IF: 03.300Volume 15, Issue 9No.295Changes in Glycemic Control and Lipid Profiles Following COVID-19 Infection in Adults with Type 2 Diabetes: A Retrospective Study in Saudi Arabia2型糖尿病成人感染COVID-19后血糖控制和血脂谱的变化：沙特阿拉伯的一项回顾性研究DOI: 10.3390/pathogens15090934
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.296A2BAR Antagonism Mitigates Pulmonary Inflammation and Fibrosis and Restores Macrophage M1/M2 Balance in Diabetic RatsA2BAR拮抗减轻糖尿病大鼠肺部炎症和纤维化并恢复巨噬细胞M1/M2平衡DOI: 10.3390/ijms27188171
Nutrients IF: 05.000Volume 18, Issue 18No.297Chronic Dietary Stress Is Associated with Early Cardiac Dysfunction and Progressive MASH Accompanied by Systemic Inflammation and Fibrosis慢性饮食应激与早期心脏功能障碍及进行性MASH相关并伴随全身性炎症和纤维化DOI: 10.3390/nu18183084
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.298From Single Agents to Synergy: Redefining Therapeutic Strategies in MASLD从单药到协同：重新定义脂肪性肝病的治疗策略DOI: 10.3390/ijms27188368
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.299AMPK-Directed Therapeutics for MASLD: Mechanistic Rationale, Activator Classes, and Clinical Translation靶向AMPK的MASLD治疗：机制依据、激活剂类别与临床转化DOI: 10.3390/ijms27188358
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.300The Role of the OSM/OSMRβ Axis in Chronic Liver Disease Progression and Hepatocellular Carcinoma Development: A Focus on MASLD/MASHOSM/OSMRβ轴在慢性肝病进展和肝细胞癌发生中的作用：聚焦于MASLD/MASHDOI: 10.3390/ijms27188213
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.301Aucubin Ameliorates Alloxan-Induced Diabetic Liver Injury in Association with Modulation of the Nrf2/HO-1 Antioxidant Axis and NF-κB-Associated Inflammatory and Apoptotic SignalingAucubin通过调节Nrf2/HO-1抗氧化轴及NF-κB相关炎症和凋亡信号改善四氧嘧啶诱导的糖尿病肝损伤DOI: 10.3390/ijms27188184
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.302Intrapancreatic Fat and Risk of Pancreatic Ductal Adenocarcinoma-Pathophysiology, Clinical Implications, and Future Directions胰腺内脂肪与胰腺导管腺癌风险——病理生理学、临床意义与未来方向DOI: 10.3390/ijms27187991
Obesity reviews IF: 07.400Ahead of Print.No.303Investigating Overweight and Obesity Risk in Shift Workers Using Omics Technologies利用组学技术探究轮班工作者超重与肥胖风险DOI: 10.1111/obr.70233
Medicine IF: 01.400Volume 105, Issue 39No.304Serum FAM19A5 in newly diagnosed type 2 diabetes mellitus and its association with metabolic and inflammatory parameters: A case-control study新诊断2型糖尿病患者的血清FAM19A5及其与代谢和炎症参数的关系：一项病例对照研究DOI: 10.1097/MD.0000000000050782
Veterinary sciences IF: 02.300Volume 13, Issue 9No.305Impact of Climate Change on Farm Animals: Physiological Mechanisms, Health and Productivity, and Integrated Adaptation Strategies气候变化对农场动物的影响：生理机制、健康与生产力及综合适应策略DOI: 10.3390/vetsci13090954
Toxics IF: 04.100Volume 14, Issue 9No.306Occupational Organophosphorus Pesticide Exposure and Metabolic Syndrome: Implications of PPARγ职业性有机磷农药暴露与代谢综合征：PPARγ的潜在意义DOI: 10.3390/toxics14090788
Pharmaceutics IF: 05.500Volume 18, Issue 9No.307Translational Pharmaceutical Perspectives on Quinones as Antioxidant and Antidiabetic Agents in Diabetes and Its Complications醌类作为抗氧化和抗糖尿病药物在糖尿病及其并发症中的转化药学视角DOI: 10.3390/pharmaceutics18091191
Pharmaceutics IF: 05.500Volume 18, Issue 9No.308Harnessing Medicinal Plants Through Advanced Drug Delivery: A New Era in Type 2 Diabetes Management通过先进药物递送利用药用植物：2型糖尿病管理的新时代DOI: 10.3390/pharmaceutics18091100
Pharmaceutics IF: 05.500Volume 18, Issue 9No.309Buccal Insulin Delivery Systems: Formulation Approaches, Stability Constraints, and Translational Prospects口腔黏膜胰岛素递送系统：制剂策略、稳定性限制与转化前景DOI: 10.3390/pharmaceutics18091093
Nutrients IF: 05.000Volume 18, Issue 18No.310More than Hormones? Metabolic Effects of Twelve-Week Probiotic Supplementation in Women with Polycystic Ovary Syndrome: A Secondary Analysis of a Randomized Double-Blind Placebo-Controlled Study超越激素？多囊卵巢综合征女性十二周益生菌补充的代谢效应：一项随机双盲安慰剂对照研究的二次分析DOI: 10.3390/nu18183090
Nutrients IF: 05.000Volume 18, Issue 18No.311Effects of Heat-Killed Bifidobacterium breve B-3, a Postbiotic, on Muscle Mass-Related Parameters in Patients with Sarcopenia: A Randomized, Double-Blind, Placebo-Controlled Pilot Trial热灭活短双歧杆菌B-3（后生元）对肌少症患者肌肉质量相关参数的影响：一项随机、双盲、安慰剂对照先导试验DOI: 10.3390/nu18183074
Nutrients IF: 05.000Volume 18, Issue 18No.312Adipose Tissue Expandability as a Link Between Nutrition and Obesity-Related Metabolic Risk: Insights from Bariatric Surgery脂肪组织扩张能力作为营养与肥胖相关代谢风险之间的纽带：来自减重手术的启示DOI: 10.3390/nu18183075
Nutrients IF: 05.000Volume 18, Issue 18No.313The TyG Index, Dietary Vitamin E Intake, and LRP5 rs4988321 in Adults with MASLD: A Case-Control Study甘油三酯-葡萄糖指数、膳食维生素E摄入与LRP5 rs4988321在成人脂肪性肝病中的病例对照研究DOI: 10.3390/nu18183065
Nutrients IF: 05.000Volume 18, Issue 18No.314The Impact of Ultra-Processed Foods on Chronic Kidney Disease Progression超加工食品对慢性肾脏病进展的影响DOI: 10.3390/nu18183055
Nutrients IF: 05.000Volume 18, Issue 18No.315Are Selenium Status and Inflammation Linked to Cardiometabolic Risk Factors in Inborn Errors of Immunity?硒状态和炎症与先天性免疫缺陷中的心血管代谢危险因素有关吗？DOI: 10.3390/nu18183030
Nutrients IF: 05.000Volume 18, Issue 18No.316Plant-Based Diets in Adolescence: Cardiometabolic Benefits, Developmental Risks, and the Role of Fortification青少年植物性饮食：心脏代谢益处、发育风险与强化作用DOI: 10.3390/nu18183019
Nutrients IF: 05.000Volume 18, Issue 18No.317Chrono-Nutritional Disruption as a Potential Modifiable Factor in Bipolar Disorder昼夜节律营养紊乱作为双相障碍潜在可改变因素的研究DOI: 10.3390/nu18183011
Nutrients IF: 05.000Volume 18, Issue 18No.318Effects of Grape and Grape-Derived Bioactives on Inflammation and Immune-Driven Mechanisms Within the Context of Cardiometabolic Health and Aging: A Review葡萄及葡萄来源生物活性物质在心血管代谢健康与衰老背景下对炎症和免疫驱动机制的影响：综述DOI: 10.3390/nu18182952
Molecules IF: 04.600Volume 31, Issue 18No.319Isolation of Phenolic Metabolites and Evaluation of the Antioxidant and Metabolic Enzyme-Inhibitory Activities of Polygonum equisetiforme SmPolygonum equisetiforme Sm. 酚类代谢物的分离及其抗氧化和代谢酶抑制活性评价DOI: 10.3390/molecules31183327
Medicina IF: 02.400Volume 62, Issue 9No.320Clinical Profile of Documented Diabetic Peripheral Neuropathy by GLP-1-Based Medication Status: A Cross-Sectional Study基于GLP-1类药物使用状态的已记录糖尿病周围神经病变临床特征：一项横断面研究DOI: 10.3390/medicina62091816
Medicina IF: 02.400Volume 62, Issue 9No.321Integrated First-Trimester Assessment of Placental Biomarkers, Metabolic Indices, and IGF-1/IGFBP-5 in Relation to Subsequent Gestational Diabetes Mellitus: A Prospective Cohort Study整合孕早期胎盘生物标志物、代谢指标及IGF-1/IGFBP-5与后续妊娠期糖尿病的关联：一项前瞻性队列研究DOI: 10.3390/medicina62091804
Medicina IF: 02.400Volume 62, Issue 9No.322Type 2 Diabetes, Visceral Adiposity, and Carotid Intima-Media Thickness in Hospitalized Adults: A Retrospective Cross-Sectional Analysis住院成人中的2型糖尿病、内脏肥胖与颈动脉内膜中层厚度：一项回顾性横断面分析DOI: 10.3390/medicina62091690
Medicina IF: 02.400Volume 62, Issue 9No.323Orbital Radiotherapy for Thyroid-Associated Orbitopathy in the Era of Targeted Biologics: Reposition, Not Replace靶向生物制剂时代甲状腺相关眼病的眶部放疗：重新定位而非替代DOI: 10.3390/medicina62091671
Medicina IF: 02.400Volume 62, Issue 9No.324Thoracic Epidural Analgesia in Major Cancer Surgery: An Update胸段硬膜外镇痛在大型癌症手术中的应用：最新进展DOI: 10.3390/medicina62091637
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.325Association of Inpatient Diabetes Specialist Consultation with Clinical Outcomes in Patients with Diabetes Hospitalized for Lower Respiratory Tract Infections: A Retrospective Cohort Study住院糖尿病专科会诊与因下呼吸道感染住院的糖尿病患者临床结局的关联：一项回顾性队列研究DOI: 10.3390/jcm15187173
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.326Phenotype-Specific Differences in Insulin Resistance and Androgenic Profiles in Polycystic Ovary Syndrome: A Prospective Observational Study多囊卵巢综合征中胰岛素抵抗与雄激素谱的表型特异性差异：一项前瞻性观察性研究DOI: 10.3390/jcm15187101
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.327Evaluation of Serum Soluble Urokinase Plasminogen Activator Receptor (suPAR) Levels in Different Metabolic Obesity Phenotypes and Their Association with Inflammatory Cytokines: A Cross-Sectional Study不同代谢性肥胖表型中血清可溶性尿激酶型纤溶酶原激活物受体（suPAR）水平的评估及其与炎症细胞因子的关联：一项横断面研究DOI: 10.3390/jcm15186990
Life IF: 03.400Volume 16, Issue 9No.328Feasibility of Multi-Wavelength LED Irradiation on the Skull and Preliminary Glycemic Outcomes in Individuals with Type 2 Diabetes: A Prospective Pilot Study多波长LED颅骨照射在2型糖尿病患者中的可行性及初步血糖结局：一项前瞻性初步研究DOI: 10.3390/life16091411
Life IF: 03.400Volume 16, Issue 9No.329Neonatal Metformin Exposure Is Associated with Altered Adult Metabolic Responses to Hyperlipidic Diet in Male Wistar Rats新生期二甲双胍暴露与雄性Wistar大鼠成年后对高脂饮食代谢反应改变相关DOI: 10.3390/life16091398
Cancers IF: 04.400Volume 18, Issue 18No.330Circulating microRNAs at the Interface of Obesity and Breast Cancer: From Molecular Machinery, Diagnostic Potential, and Therapeutic Perspectives肥胖与乳腺癌交界处的循环microRNA：从分子机制、诊断潜力到治疗前景DOI: 10.3390/cancers18183035
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.331GLP-1 Receptor Agonists as Molecular Relievers of Lipotoxic Stress: From Pancreatic Beta-Cell Cholesterol Efflux to Systemic and Tissue-Specific Metabolic ProtectionGLP-1受体激动剂作为脂毒性应激的分子缓解剂：从胰腺β细胞胆固醇外流到全身及组织特异性代谢保护DOI: 10.3390/ijms27188378
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.332Adipokines as Regulators of Nitric Oxide Synthase Isoforms Across Organs: Emerging Implications for Gastrointestinal Motility脂肪因子作为跨器官一氧化氮合酶亚型的调节因子：对胃肠动力的新兴意义DOI: 10.3390/ijms27188373
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.333Adipocyte Ferroptosis in Obesity: Molecular Mechanisms and Nutraceutical Perspectives肥胖中的脂肪细胞铁死亡：分子机制与营养保健品视角DOI: 10.3390/ijms27188357
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.334Polyol-Functionalized Manganese-Based Nanoparticles: From Insulin Amyloid Inhibition to Nanozyme-Mediated Antioxidant Activity多元醇功能化锰基纳米颗粒：从胰岛素淀粉样蛋白抑制到纳米酶介导的抗氧化活性DOI: 10.3390/ijms27188321
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.335Withania somnifera (Ashwagandha) Improves Fitness in Aged Drosophila by Reducing AKT Phosphorylation睡茄（南非醉茄）通过降低AKT磷酸化改善衰老果蝇的体能DOI: 10.3390/ijms27188314
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.336A Chemically Characterized Polyherbal Extract Selectively Attenuates Chronic Unpredictable Stress-Induced Redox-Sensitive, Inflammatory, and Metabolic Alterations in Female Rats一种经化学表征的复方草药提取物选择性减轻雌性大鼠慢性不可预测应激诱导的氧化还原敏感、炎症及代谢改变DOI: 10.3390/ijms27188298
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.337Reframing Alzheimer's Disease Through a Redox-Metabolic Framework通过氧化还原-代谢框架重新认识阿尔茨海默病DOI: 10.3390/ijms27188294
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.338Circulating Asprosin Declines During 24 Months of Growth Hormone Replacement and Is Associated with IGF-1 and Metabolic Remodeling in Adults with Growth Hormone Deficiency循环白脂素在生长激素替代治疗24个月期间下降，并与成人生长激素缺乏症患者的胰岛素样生长因子-1和代谢重塑相关DOI: 10.3390/ijms27188225
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.339GLP-1 and Dual GIP/GLP-1 Receptor Agonists in Pediatric Obesity: From Neuroendocrine Mechanisms to Clinical ApplicationGLP-1与双重GIP/GLP-1受体激动剂在儿童肥胖中的应用：从神经内分泌机制到临床应用DOI: 10.3390/ijms27188191
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.340Obesity, Oxidative Stress, and Inflammation in Precocious Puberty: Do All Roads Lead to the Hypothalamus?肥胖、氧化应激与炎症在性早熟中的作用：所有通路都通向 hypothalamus 吗？DOI: 10.3390/ijms27188159
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.341Dietary Nucleotides as Potential Modulators of Inflammatory and Metabolic Pathways with Implications for Insulin Resistance膳食核苷酸作为炎症和代谢通路的潜在调节剂及其对胰岛素抵抗的影响DOI: 10.3390/ijms27188133
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.342Coptidis Rhizoma for Obesity, Diabetes, and Dyslipidemia: An Integrated Meta-Analysis and In Silico Study黄连用于肥胖、糖尿病和血脂异常：一项整合的荟萃分析和计算机模拟研究DOI: 10.3390/ijms27188109
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.343Immunometabolism in Obesity-Associated Type 2 Diabetes: Molecular Mechanisms and Emerging Therapeutic Targets肥胖相关2型糖尿病中的免疫代谢：分子机制与新兴治疗靶点DOI: 10.3390/ijms27188063
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.344Diet-Dependent Effects of Intracerebroventricular Maresin-1 on Hypothalamus of Rats饮食依赖性脑室内注射Maresin-1对大鼠下丘脑的影响DOI: 10.3390/ijms27188039
Gels IF: 05.300Volume 12, Issue 9No.345Gel-Based Drug Delivery Platforms: A Critical, Mechanistic Review of Design, Cross-Linking, and Disease-Specific Translation (2010-2026)基于凝胶的药物递送平台：设计、交联与疾病特异性转化的批判性机制综述（2010-2026）DOI: 10.3390/gels12090787
Children IF: 02.100Volume 13, Issue 9No.346Psychological and Glycemic Outcomes Associated with EMDR Therapy in Children and Adolescents with Type 1 Diabetes Mellitus: A Retrospective Comparative Study儿童和青少年1型糖尿病患者接受EMDR治疗相关的心理和血糖结局：一项回顾性比较研究DOI: 10.3390/children13091262
Children IF: 02.100Volume 13, Issue 9No.347Biomarkers of Treatment-Escalation Risk by Obesity Status in Pediatric Asthma: A Development and External Validation Cohort Study儿童哮喘中按肥胖状态划分的治疗升级风险生物标志物：一项开发与外部验证队列研究DOI: 10.3390/children13091242
Children IF: 02.100Volume 13, Issue 9No.348Clinical and Hormonal Characteristics and Short-Term Outcomes of Diazoxide Use in Hypoglycemic Neonates: A Retrospective Cohort Study低血糖新生儿使用二氮嗪的临床与激素特征及短期结局：一项回顾性队列研究DOI: 10.3390/children13091157
Foods IF: 05.100Volume 15, Issue 18No.349Consumer Acceptability and Metabolic Health Benefits of Meals Containing Pulses (Chickpeas, Lentils, Peas) for Sedentary Office Workers含豆类（鹰嘴豆、小扁豆、豌豆）的膳食对久坐办公人员的消费者可接受性及代谢健康益处DOI: 10.3390/foods15183302
Foods IF: 05.100Volume 15, Issue 18No.350Rice-Flour-Based Diet Is Associated with Reduced Obesity-Related and Glucose-Related Outcomes and Increased Ucp3 Expression in KK-Ay Mice米粉基饮食与KK-Ay小鼠肥胖相关及葡萄糖相关结局改善和Ucp3表达增加相关DOI: 10.3390/foods15183209
Diagnostics IF: 03.300Volume 16, Issue 18No.351Association of the Triglyceride-Glucose Index with Premature Myocardial Infarction in a Propensity Score-Matched Non-Diabetic Population甘油三酯-葡萄糖指数与倾向性评分匹配的非糖尿病人群中早发心肌梗死的关联DOI: 10.3390/diagnostics16182999
Curr Issues Mol Biol IF: 03.000Volume 48, Issue 9No.352Sex-Dependent Effects of Exogenous Irisin on Pancreatic Endocrine-Cell Immunophenotype in Post-Weaning Wistar Rats外源性鸢尾素对断奶后Wistar大鼠胰腺内分泌细胞免疫表型的性别依赖性影响DOI: 10.3390/cimb48090967
Curr Issues Mol Biol IF: 03.000Volume 48, Issue 9No.353Functional Connections Between Insulin and Neurotrophin-3 in Hemodialysis Patients with Type 2 Diabetes胰岛素与Neurotrophin-3在2型糖尿病血液透析患者中的功能联系DOI: 10.3390/cimb48090884
Curr Issues Mol Biol IF: 03.000Volume 48, Issue 9No.354Liposomal Nanocarriers in Non-Alcoholic Fatty Liver Disease: A Systematic Review of Formulation Design, Targeting Strategies, and Therapeutic Outcomes脂质体纳米载体在非酒精性脂肪性肝病中的应用：制剂设计、靶向策略及治疗结果的系统综述DOI: 10.3390/cimb48090883
Curr Issues Mol Biol IF: 03.000Volume 48, Issue 9No.355Glucose Transporters: Structure, Trafficking, Physiology, and Disease Relevance葡萄糖转运体：结构、转运、生理学及疾病相关性DOI: 10.3390/cimb48090861
Biomolecules IF: 04.800Volume 16, Issue 9No.356Salivary Versus Circulating Insulin in Humans: Quantitative Evidence and Validation Requirements人类唾液胰岛素与循环胰岛素：定量证据与验证要求DOI: 10.3390/biom16091348
Biomolecules IF: 04.800Volume 16, Issue 9No.357Dystrophin Deficiency Creates a Pro-Ferroptotic Environment in Diaphragm of mdx Mice That Is Modified by Diet and Glucocorticoid Treatment肌营养不良蛋白缺乏在mdx小鼠膈肌中营造促铁死亡环境，并受饮食和糖皮质激素治疗调节DOI: 10.3390/biom16091347
Biomolecules IF: 04.800Volume 16, Issue 9No.358Circulating Amino Acid Profiles in Adults with Abnormal Body Mass Index: Associations with Triglycerides, HDL Cholesterol, LDL Cholesterol, and Total Cholesterol in an Exploratory Cross-Sectional Metabolomic Pilot Study体重指数异常成人的循环氨基酸谱：一项探索性横断面代谢组学初步研究中与甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇和总胆固醇的关联DOI: 10.3390/biom16091305
Biomolecules IF: 04.800Volume 16, Issue 9No.359IGF-1Eb Isoform Immunoreactivity May Be Associated with Placental Dysfunction and Vascular Pathology in Fetal Growth Restriction (FGR)IGF-1Eb异构体免疫反应性可能与胎儿生长受限中的胎盘功能障碍和血管病理相关DOI: 10.3390/biom16091281
Biomedicines IF: 03.900Volume 14, Issue 9No.360Concurrent Inhibition of AKT and GLUT1 Reveals Endpoint-Specific Effects on Glucose Metabolism and Cell Death in HepG2 Hepatocyte-Derived Cells同时抑制AKT和GLUT1揭示对HepG2肝细胞衍生细胞葡萄糖代谢和细胞死亡的终点特异性效应DOI: 10.3390/biomedicines14092133
Biomedicines IF: 03.900Volume 14, Issue 9No.361Immunometabolic Dysregulation in Female Obesity: Mechanistic Links to Ovarian Dysfunction, Implantation Failure, and Preeclampsia女性肥胖中的免疫代谢失调：与卵巢功能障碍、着床失败和子痫前期的机制联系DOI: 10.3390/biomedicines14092039
Biomedicines IF: 03.900Volume 14, Issue 9No.362Insulin Tolerance Test in Adult GH Deficiency: An Exploratory Study Deriving BMI-Dependent Cut-Offs Using a Clinical Reference Standard成人生长激素缺乏症中的胰岛素耐量试验：一项利用临床参考标准推导体重指数依赖性切点的探索性研究DOI: 10.3390/biomedicines14092001
Biomedicines IF: 03.900Volume 14, Issue 9No.363The Emerging Potential of Diabetes Technology to Improve Metabolic Dysfunction-Associated Steatotic Liver Disease in Patients with Type 1 Diabetes: A Narrative Review糖尿病技术改善1型糖尿病患者代谢功能障碍相关脂肪性肝病的潜在新前景：叙述性综述DOI: 10.3390/biomedicines14091986
Biomedicines IF: 03.900Volume 14, Issue 9No.364Interorgan Crosstalk in MASLD: A Narrative ReviewMASLD中的器官间串扰：叙述性综述DOI: 10.3390/biomedicines14091949
Biomedicines IF: 03.900Volume 14, Issue 9No.365Iron Deficiency in Endocrine Diseases and the Therapeutic Role of Liposomal Iron: A Comprehensive Review内分泌疾病中的铁缺乏与脂质体铁的治疗作用：一项综合性综述DOI: 10.3390/biomedicines14091944
Antioxidants IF: 06.600Volume 15, Issue 9No.366Betaine in Metabolic Dysfunction-Associated Steatotic Liver Disease: Mechanisms of Action and Therapeutic Potential甜菜碱在代谢功能障碍相关脂肪性肝病中的作用机制与治疗潜力DOI: 10.3390/antiox15091209
Antioxidants IF: 06.600Volume 15, Issue 9No.367Soursop-Derived Gut Metabolites Restore Adipose Metabolic Homeostasis and Attenuate Fructose-Induced Adipotoxicity: Mechanistic Insights into the Soursop-Gut-Adipose Axis刺果番荔枝来源的肠道代谢物恢复脂肪代谢稳态并减轻果糖诱导的脂肪毒性：刺果番荔枝-肠道-脂肪轴机制见解DOI: 10.3390/antiox15091106
Antioxidants IF: 06.600Volume 15, Issue 9No.368Antidiabetic Properties of Histamine H1 Receptor Antagonists: A Systematic Review组胺H1受体拮抗剂的抗糖尿病特性：一项系统综述DOI: 10.3390/antiox15091098
Physiological reports IF: 01.900Volume 14, Issue 18No.369Acute high-protein feeding induces hepatic amino acid accumulation in diabetic male mice prior to transcriptional adaptation急性高蛋白喂养在转录适应之前诱导糖尿病雄性小鼠肝脏氨基酸积累DOI: 10.14814/phy2.71117
BMC medicine IF: 08.300Volume 24, Issue 1No.370Biological signature of dietary patterns in older adults: findings from a population-based study老年人饮食模式的生物学特征：一项基于人群的研究发现DOI: 10.1186/s12916-026-05202-2
Obesity surgery IF: 03.100Ahead of Print.No.371Association Between Cholecystectomy and Gastroesophageal Inflammatory Findings After Sleeve Gastrectomy: Endoscopic and Metabolic Evaluation胆囊切除术与袖状胃切除术后胃食管炎症表现的关联：内镜与代谢评估DOI: 10.1007/s11695-026-08947-0
J Gen Intern Med IF: 04.200Ahead of Print.No.372Authors Respond: Insulin Glargine Utilization and Spending Before and After the First Biosimilar Insulin Glargine: A Real-World Data Study作者回应：首个甘精胰岛素生物类似药上市前后的甘精胰岛素使用与支出：一项真实世界数据研究DOI: 10.1007/s11606-026-10837-1
Journal of Human Hypertension IF: 03.400Ahead of Print.No.373Association between the triglyceride/high-density lipoprotein cholesterol ratio and isolated nocturnal hypertension甘油三酯/高密度脂蛋白胆固醇比值与单纯夜间高血压的关联DOI: 10.1038/s41371-026-01230-w
BMC pediatrics IF: 02.000Volume 26, Issue 1No.374Parental needs and experiences with e-Health applications in chronic pediatric care - a scoping review慢性儿科护理中家长对电子健康应用的需求与体验——一项范围综述DOI: 10.1186/s12887-026-07737-y
Healthcare IF: 02.700Volume 14, Issue 18No.375Awareness of Diabetic Ketoacidosis and Associated Factors Among Adults with Diabetes or a Family Member with Diabetes in Jazan, Saudi Arabia沙特阿拉伯Jazan地区糖尿病患者或其家庭成员对糖尿病酮症酸中毒的认知及相关因素DOI: 10.3390/healthcare14183042
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.376Low Serum C-Peptide and Albuminuria Severity in Type 2 Diabetes Mellitus: A Cross-Sectional Study2型糖尿病中低血清C肽与白蛋白尿严重程度的横断面研究DOI: 10.3390/jcm15186950
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.377MORG1 Haploinsufficiency Is Associated with Stage- and Sex-Dependent Renoprotection and Signalling Alterations in Diabetic Kidney DiseaseMORG1单倍体不足与糖尿病肾病中阶段和性别依赖的肾脏保护及信号改变相关DOI: 10.3390/ijms27187990
Antioxidants IF: 06.600Volume 15, Issue 9No.378PCSK9 Inhibition Attenuates Renal Oxidative Stress and Lipotoxicity in Diabetic Kidney Disease in Association with AMPK Activation抑制前蛋白转化酶枯草溶菌素/kexin 9型可减轻糖尿病肾病中的肾脏氧化应激和脂毒性并与AMPK激活相关DOI: 10.3390/antiox15091182
Medicina IF: 02.400Volume 62, Issue 9No.379Association of SGLT2 Inhibitor Use with Glycosuria, Pyuria, Urinary Symptoms, and Significant Urine Culture Positivity in Adults with Type 2 Diabetes: A Prospective Cross-Sectional StudySGLT2抑制剂使用与成人2型糖尿病患者尿糖、脓尿、泌尿系统症状及显著尿培养阳性的关联：一项前瞻性横断面研究DOI: 10.3390/medicina62091721
Biomedicines IF: 03.900Volume 14, Issue 9No.380Preliminary Evaluation of SGLT2 Inhibitors in Human Bladder Cancer T24 CellsSGLT2抑制剂在人膀胱癌T24细胞中的初步评估DOI: 10.3390/biomedicines14092037
Biomedicines IF: 03.900Volume 14, Issue 9No.381Metabolic and Lipoprotein Changes in Type 2 Diabetes Patients Treated with Empagliflozin恩格列净治疗2型糖尿病患者的代谢与脂蛋白变化DOI: 10.3390/biomedicines14092016
Handb Exp PharmacolAhead of Print.No.382Effects of SGLT2 Inhibitors in Rodent Models of Diabetic NephropathySGLT2抑制剂在糖尿病肾病啮齿动物模型中的效应DOI: 10.1007/164_2026_845
Pharmaceuticals IF: 04.800Volume 19, Issue 9No.383Design, Synthesis and Antihyperglycemic/Antilipidemic Activities of Quinoline-thiazolidine-2,4-dione Hybrid喹啉-噻唑烷-2,4-二酮杂合物的设计、合成及其抗高血糖/抗高脂血症活性DOI: 10.3390/ph19091490
Front Cell Infect Microbiol IF: 04.800Volume 16, Issue No.384Fecal microbiota transplantation from duodenal light stimulation-conditioned donors is associated with improved glucose tolerance and intestinal incretin-related remodeling in diabetic Goto-Kakizaki rats来自十二指肠光刺激供体的粪菌移植与糖尿病Goto-Kakizaki大鼠糖耐量改善及肠道肠促胰岛素相关重塑相关DOI: 10.3389/fcimb.2026.1900693
Front Clin Diabetes Healthc IF: 02.200Volume 7, Issue No.385COVID-19 pandemic and the management of type-2 diabetes mellitus among women in Fiji: concerns and context specific interventionsCOVID-19大流行与斐济女性2型糖尿病管理：关切与情境特异性干预措施DOI: 10.3389/fcdhc.2026.1846673
Oxford medical case reports IF: 00.400Volume 2026, Issue 9No.386Descending necrotizing mediastinitis after pharyngeal fish bone impaction: a case report咽部鱼骨嵌顿后发生下行性坏死性纵隔炎：一例病例报告DOI: 10.1093/omcr/omag177
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.387COVID-19 and subsequent risk of coded diabetic retinopathy in patients with type 2 diabetes: a multicenter propensity score-matched cohort studyCOVID-19与2型糖尿病患者后续编码糖尿病视网膜病变风险：一项多中心倾向评分匹配队列研究DOI: 10.3389/fendo.2026.1914361
Medicine IF: 01.400Volume 105, Issue 39No.388Health literacy and the health belief model in type 2 diabetes mellitus: A bibliometric analysis of global research trends (1982-2026)2型糖尿病中的健康素养与健康信念模型：全球研究趋势的文献计量学分析（1982-2026）DOI: 10.1097/MD.0000000000050857
Nutrients IF: 05.000Volume 18, Issue 18No.389Effects of Curcumin Supplementation on Inflammatory Biomarkers in Adults with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials姜黄素补充对成人2型糖尿病患者炎症生物标志物的影响：随机对照试验的系统综述与Meta分析DOI: 10.3390/nu18183028
Nutrients IF: 05.000Volume 18, Issue 18No.390Macronutrient Intake and Carbohydrate Quality in Indian Adults With and Without Type 2 Diabetes: The Multicentre I-STARCH-1 Cross-Sectional Study印度2型糖尿病与非2型糖尿病成人的宏量营养素摄入与碳水化合物质量：多中心I-STARCH-1横断面研究DOI: 10.3390/nu18182993
Nutrients IF: 05.000Volume 18, Issue 18No.391Beneficial Roles of Bioconversion-Derived Metabolites of Dietary Components as Potential Biological Regulators in Obesity and Type 2 Diabetes Mellitus膳食成分生物转化衍生代谢物在肥胖和2型糖尿病中作为潜在生物调节剂的有益作用DOI: 10.3390/nu18182980
Nutrients IF: 05.000Volume 18, Issue 18No.392Therapeutic Potential of Selected Flavonoids as Natural Antidiabetic Agents选定黄酮类化合物作为天然抗糖尿病药物的治疗潜力DOI: 10.3390/nu18182944
Molecules IF: 04.600Volume 31, Issue 18No.393Synthesis and Biological Evaluation of 1,3,5-Triazine Derivatives for GPR119 Agonistic Activity1,3,5-三嗪衍生物的合成及其GPR119激动活性的生物学评价DOI: 10.3390/molecules31183289
Medicina IF: 02.400Volume 62, Issue 9No.394Potentially Inappropriate Medication Use in Older Adults in Primary Care According to Four Explicit Criteria: Associations with Patient Factors根据四种明确标准评估初级保健中老年人潜在不适当用药：与患者因素的关联DOI: 10.3390/medicina62091813
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.395Integrated Cardio-Renal-Metabolic Risk Profiling in Patients with Type 2 Diabetes: A Machine Learning-Assisted Cross-Sectional Analysis2型糖尿病患者的心-肾-代谢综合风险分析：一项机器学习辅助的横断面研究DOI: 10.3390/jcm15187315
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.396Serum Neurofilament Light Chain in Diabetic Polyneuropathy: Associations with Neuropathy Burden, Balance Impairment, and Fear of Falling糖尿病多发性神经病中的血清神经丝轻链：与神经病负担、平衡障碍及跌倒恐惧的关联DOI: 10.3390/jcm15187142
Microorganisms IF: 04.200Volume 14, Issue 9No.397Toward AI-Driven Detection of Asymptomatic Chronic Conditions from Stool Metagenomics and Dietary Data: A Multimodal Deep Learning Framework for T1DM, T2DM, MOS/PCOS, Cancer, and Autoimmune Disease迈向基于粪便宏基因组和饮食数据的人工智能驱动无症状慢性病检测：针对T1DM、T2DM、MOS/PCOS、癌症和自身免疫性疾病的多模态深度学习框架DOI: 10.3390/microorganisms14091880
Life IF: 03.400Volume 16, Issue 9No.398Effects of Bioactive Microalgal Pigment Intake on Metabolic Parameters, Cecal Distribution and Short-Chain Fatty Acids in a Diabetic Rat Model生物活性微藻色素摄入对糖尿病大鼠模型代谢参数、盲肠分布及短链脂肪酸的影响DOI: 10.3390/life16091540
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.399Trajectory-Oriented Brain Vulnerability Framework for Cognitive Decline in Type 2 Diabetes面向轨迹的2型糖尿病认知衰退脑脆弱性框架DOI: 10.3390/ijms27188342
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.400Skeletal Muscle Effects of GLP 1 Receptor Agonists: Molecular Mechanisms and Comparative Insights on Semaglutide and Tirzepatide, a Narrative ReviewGLP-1受体激动剂的骨骼肌效应：分子机制及司美格鲁肽与替尔泊肽的比较性叙述综述DOI: 10.3390/ijms27188057
Diagnostics IF: 03.300Volume 16, Issue 18No.401Lifestyle Adherence and Metabolic Control in Adults with Type 2 Diabetes: Development of a Lifestyle Compliance Index2型糖尿病成人的生活方式依从性与代谢控制：生活方式依从性指数的开发DOI: 10.3390/diagnostics16183068
Diagnostics IF: 03.300Volume 16, Issue 18No.402Factors Associated with Clinically Inadequate Bowel Preparation Among Patients with Diabetes Mellitus Undergoing Colonoscopy: A Single-Center Observational Study糖尿病患者结肠镜检查中临床肠道准备不充分的相关因素：一项单中心观察性研究DOI: 10.3390/diagnostics16182935
Healthcare IF: 02.700Volume 14, Issue 18No.403Reducing Thirty-Day Readmissions Among Geriatric Patients Through Multidisciplinary Care: A Tertiary Center Experience通过多学科护理降低老年患者30天再入院率：一家三级中心的经验DOI: 10.3390/healthcare14182991
Healthcare IF: 02.700Volume 14, Issue 18No.404Association Between Baseline Glucagon-like Peptide-1 Receptor Agonist Use and Newly Documented Depression Diagnosis in Adults with Type 2 Diabetes: A Multi-State Medicaid Cohort Study基线胰高血糖素样肽-1受体激动剂使用与成人2型糖尿病新发抑郁诊断的关联：一项多州Medicaid队列研究DOI: 10.3390/healthcare14182971
Healthcare IF: 02.700Volume 14, Issue 18No.405Mediterranean Diet Adherence and Sustainable Eating Behaviors in Type 2 Diabetes: A Cross-Sectional Analysis of Adiposity, Cooking and Food Skills, and Macrovascular Complications2型糖尿病中的地中海饮食依从性与可持续饮食行为：对肥胖、烹饪与食物技能及大血管并发症的横断面分析DOI: 10.3390/healthcare14182934
Curr Issues Mol Biol IF: 03.000Volume 48, Issue 9No.406Hyperglycemic Adipocyte-Derived Exosomes Cause Oxidative Stress and Lipid Peroxidation in Brain Microvascular Endothelial Cells高血糖脂肪细胞来源外泌体导致脑微血管内皮细胞氧化应激和脂质过氧化DOI: 10.3390/cimb48090896
Biomedicines IF: 03.900Volume 14, Issue 9No.407Circulating Ghrelin, Nesfatin-1, and Vaspin Levels Across Glycemic Control Categories in Type 2 Diabetes Mellitus: A Cross-Sectional Study2型糖尿病不同血糖控制类别中循环胃饥饿素、nesfatin-1和vaspin水平：一项横断面研究DOI: 10.3390/biomedicines14092055
Biomedicines IF: 03.900Volume 14, Issue 9No.408Antioxidants in Oxidative Stress and Obesity-Associated Diseases: Molecular Mechanisms and Potential Health Implications抗氧化剂在氧化应激与肥胖相关疾病中的作用：分子机制与潜在健康意义DOI: 10.3390/biomedicines14092049
Biomedicines IF: 03.900Volume 14, Issue 9No.409Imaging and Hemodynamic Mechanisms of Cardiac Remodeling with SGLT2 Inhibitors Across Heart Failure Phenotypes: A Systematic ReviewSGLT2抑制剂在不同心力衰竭表型中导致心脏重构的影像学与血流动力学机制：一项系统评价DOI: 10.3390/biomedicines14091961
Biomedicines IF: 03.900Volume 14, Issue 9No.410Data-Driven Multidimensional Clinical Phenotypes and Longitudinal Changes in Type 2 Diabetes Mellitus: A Retrospective Cohort Study数据驱动的多维临床表型与2型糖尿病的纵向变化：一项回顾性队列研究DOI: 10.3390/biomedicines14091903
Biomedicines IF: 03.900Volume 14, Issue 9No.411Mitophagy and Noncoding RNA Regulation in Type 2 Diabetes Mellitus: Molecular Mechanisms, Tissue-Specific Evidence and Translational Perspective2型糖尿病中的线粒体自噬与非编码RNA调控：分子机制、组织特异性证据及转化前景DOI: 10.3390/biomedicines14091886
Biology IF: 03.500Volume 15, Issue 18No.412Premature Coronary Artery Disease, Association with Relative Blood Number of Mitochondrial DNA Copies in Mexican Population-Results of GEA Study早发冠状动脉疾病与墨西哥人群线粒体DNA相对血液拷贝数的关联——GEA研究结果DOI: 10.3390/biology15181572
Bioengineering IF: 03.700Volume 13, Issue 9No.413Unravelling the Impact of Diabetes on Insulin-like Growth Factor (IGF) Axis Signalling in Mesenchymal Stem Cells Isolated from the Bone of Knee Joints揭示糖尿病对膝关节骨来源间充质干细胞中胰岛素样生长因子（IGF）轴信号的影响DOI: 10.3390/bioengineering13091043
BMC health services research IF: 03.000Volume 26, Issue 1No.414Validation and psychometric evaluation of the Diabetes Quality-of-Life Brief Clinical Inventory: Tamil version (DQoL-BCI-T)糖尿病生活质量简明临床量表的验证与心理测量学评估：泰米尔语版本（DQoL-BCI-T）DOI: 10.1186/s12913-026-15638-0
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.415Effects of DPP4 Inhibition on Inflammation and Oxidative Stress in Experimental Gestational Diabetes MellitusDPP4抑制对实验性妊娠期糖尿病炎症和氧化应激的影响DOI: 10.3390/ijms27188303
Medicine IF: 01.400Volume 105, Issue 39No.416Mass-forming ischemic colitis mimicking colon cancer: A case report of early repeat colonoscopy肿块型缺血性结肠炎模拟结肠癌：早期重复结肠镜检查的病例报告DOI: 10.1097/MD.0000000000050814
Medicina IF: 02.400Volume 62, Issue 9No.417Cardiovascular-Kidney-Metabolic Syndrome and Its Hepatic Dimension: A Narrative Review心血管-肾脏-代谢综合征及其肝脏维度：叙述性综述DOI: 10.3390/medicina62091742
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.418Cardiovascular Risk in Psoriatic Arthritis in the Treat-to-Target Era: A Focused Expert Narrative Review of Epidemiology, Risk Assessment, Vascular Imaging, and Prevention达标治疗时代银屑病关节炎的心血管风险：流行病学、风险评估、血管影像与预防的聚焦专家叙述性综述DOI: 10.3390/jcm15187283
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.419Metabolic Complications in Autoimmune and Autoinflammatory Diseases: Pathophysiology, Clinical Implications, and Therapeutic Perspectives自身免疫性和自身炎症性疾病的代谢并发症：病理生理学、临床意义和治疗前景DOI: 10.3390/jcm15187199
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.420Osteoporosis and Coronary Artery Disease Burden in Older Adults with Chronic Coronary Syndrome: A Two-Center Cross-Sectional Study in Vietnam骨质疏松与慢性冠脉综合征老年患者冠状动脉疾病负担：一项越南双中心横断面研究DOI: 10.3390/jcm15187009
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.421The Role of Regulatory T Cells in Periodontitis With or Without Systemic Diseases: A Systematic Review调节性T细胞在伴或不伴系统性疾病的牙周炎中的作用：一项系统综述DOI: 10.3390/ijms27188415
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.422Features of Lipid Disorders in Cardiovascular-Kidney-Metabolic Syndrome心血管-肾脏-代谢综合征中脂质紊乱的特征DOI: 10.3390/ijms27188317
Biomolecules IF: 04.800Volume 16, Issue 9No.423Apolipoprotein E Mimetic Peptide-Mediated Modulation of Lipid Homeostasis载脂蛋白E模拟肽介导的脂质稳态调节DOI: 10.3390/biom16091352
Biomolecules IF: 04.800Volume 16, Issue 9No.424Perspectives of Natural Products and Sialic Acid Mimetics as Modulators of Human Sialidases NEU1-3 in Atherosclerosis天然产物和唾液酸模拟物作为人唾液酸酶NEU1-3调节剂在动脉粥样硬化中的前景DOI: 10.3390/biom16091319
Biomedicines IF: 03.900Volume 14, Issue 9No.425Lichen-Derived Bioactive Compounds in Diabetes and Cardiovascular Risk: Experimental Evidence, Mechanisms, and Translational Challenges地衣来源生物活性化合物在糖尿病和心血管风险中的作用：实验证据、机制和转化挑战DOI: 10.3390/biomedicines14092083
301
Diabetes Mellitus(DM)
糖尿病
188
Obesity
肥胖症
143
Insulin
胰岛素
72
Type 2 diabetes mellitus(T2DM)
2型糖尿病
27
Metabolic Syndrome
代谢综合征
21
Metformin
二甲双胍
17
Semaglutide
司美格鲁肽
15
Diabetic Retinopathy
糖尿病视网膜病
13
Glucagon-Like Peptide-1 Receptor Agonists(GLP-1RA)
胰高血糖素样肽-1受体激动剂
11
Hypoglycemic Agents
降糖药
10
Gestational Diabetes Mellitus(GDM)
妊娠糖尿病
10
Diabetic Foot
糖尿病足
10
Tirzepatide
替尔泊肽
7
Dapagliflozin
达格列净
5
Empagliflozin
恩格列净
5
Diabetes Complications
糖尿病并发症
5
Diabetic Kidney Disease(DKD)
糖尿病肾脏病
5
Liraglutide
利拉鲁肽
4
Dulaglutide
度拉糖肽
4
Exenatide
艾塞那肽
4
Gastrointestinal lipase inhibitor
胃肠道脂肪酶抑制剂
4
Orlistat
奥利司他
4
Type 1 diabetes mellitus(T1DM)
1型糖尿病
4
Diabetic Neuropathies
糖尿病性神经病变
4
Sodium-Glucose Transporter 2 Inhibitors(SGLT-2i)
钠-葡萄糖协同转运蛋白2抑制剂
3
Diabetic acidosis
糖尿病性酸中毒
3
Diabetic Peripheral Neuropathy(PDN)
糖尿病周围神经病变
2
Canagliflozin
卡格列净
1
Diabetic Cardiomyopathies
糖尿病心肌病
1
Ecnoglutide
埃诺格鲁肽
1
gamma-Aminobutyric Acid(GABA)
γ-氨基丁酸
1
Pregabalin
普瑞巴林
1
Dipeptidyl-Peptidase IV Inhibitors(DPP-4i)
二肽基肽酶-4抑制剂
1
Vildagliptin
维格列汀
1
Sitagliptin
西他列汀
1
Albiglutide
阿必鲁肽
1
Lixisenatide
利司那肽
编辑：天纳乾坤
审校：天纳乾坤
临床研究
2026-09-20
·生物探索
引言
铜死亡（cuproptosis）提出后，一个关键问题始终没有完全解决：铜进入细胞、扰乱线粒体蛋白之后，究竟是什么分子事件把这种代谢压力转化为不可逆的细胞死亡？
近日，《Cell》的研究报道“Copper ion-induced MYH9 polymerization executes cuproptosis”，研究人员将目光从线粒体进一步推向细胞骨架，发现肌球蛋白重链9（myosin heavy-chain 9，MYH9）可能是铜死亡的关键“执行蛋白”：铜促使MYH9聚合，继而破坏肌动蛋白骨架并导致细胞死亡。
更值得关注的是，研究还发现一种化合物HThPA能够动员细胞自身储存的铜，而耐药肿瘤中较高的铜水平，反而可能成为一种可以利用的代谢弱点。
铜死亡已经知道“从哪里开始”，但还不知道“最后怎么死”
2022年提出的铜死亡概念，改变了我们对铜毒性的理解。
过量铜并不是简单依靠氧化应激杀伤细胞。已有研究发现，铜能够结合线粒体三羧酸循环（TCA cycle）中的脂酰化蛋白，引起蛋白异常聚集，同时导致铁硫簇相关蛋白减少，最终产生一种区别于凋亡（apoptosis）、铁死亡（ferroptosis）和焦亡（pyroptosis）的细胞死亡方式。
但这里存在一个重要缺口。
焦亡有Gasdermin家族形成膜孔，坏死性凋亡（necroptosis）有MLKL参与膜破坏。也就是说，这些细胞死亡方式不仅有上游信号，还有比较清楚的“执行步骤”。
那么，铜死亡的执行步骤是什么？
研究人员首先用双硫仑（disulfiram，DSF）和elesclomol（ES）等铜离子载体诱导铜死亡，再对铜诱导形成的高分子量蛋白聚合物进行质谱分析。结果发现，MYH9是其中丰度最高的蛋白之一。
进一步实验显示，无论是在体外直接加入铜，还是通过DSF、ES把铜送入细胞，MYH9都会发生明显聚合；而使用铜螯合剂后，这种聚合基本消失。
更重要的是，敲除MYH9后，虽然上游铜水平仍然升高，但典型的细胞收缩、ATP下降和细胞死亡明显受到抑制。在小鼠移植瘤中，降低MYH9表达同样会削弱铜离子载体的抗肿瘤作用，而并不阻止铜本身在肿瘤中的积累。
这意味着MYH9不是简单伴随铜死亡发生变化，而是位于铜积累之后、细胞死亡之前的关键节点。
两个半胱氨酸，让MYH9成为铜的“感应器”
铜为什么能够让MYH9聚在一起？
研究人员逐步缩小了铜结合区域，最后把关键位置锁定在MYH9的两个半胱氨酸残基：Cys896和Cys1834。
当这两个位点同时突变后，铜与MYH9的结合显著受阻，MYH9无法正常形成高分子聚合物，随后发生的铜死亡也受到明显抑制。
还原剂2-ME、DTT和TCEP同样能够破坏MYH9聚合，说明这一过程与半胱氨酸之间形成的化学连接密切相关。研究人员据此提出一种可能机制：铜可能在不同MYH9分子的巯基之间参与形成类似 S-Cu-S配位结构，帮助蛋白彼此连接。
但该研究对此保持了谨慎态度：目前已经证明Cys896和Cys1834对铜结合和MYH9聚合非常关键，但铜与MYH9结合的具体化学计量关系，以及是否确实由S-Cu-S结构直接连接不同MYH9分子，仍需要进一步的生物物理研究确认。
这一区分非常重要：实验已经确定了关键位点，但完整的化学机制尚未结束。
铜浓度不到1 μM，为什么仍能推动MYH9聚合？
还有一个看似矛盾的问题。
体外加入较高浓度的铜可以让MYH9聚合并不难理解，但细胞内游离铜受到严格控制，论文引用的数据提示其浓度通常低于 1 μM。在这样的环境中，MYH9为什么仍然能够有效结合铜？
答案指向另一种蛋白：二氢硫辛酰胺S-乙酰转移酶（dihydrolipoamide S-acetyltransferase，DLAT）。
DLAT原本主要位于线粒体基质，也是早期铜死亡机制中非常重要的脂酰化蛋白。这项研究发现，在铜死亡过程中，线粒体受到破坏，一部分DLAT释放到胞质，并与MYH9结合。
进入胞质后的DLAT表现出乙酰转移酶活性，能够促进MYH9乙酰化（acetylation）。
这一步看似只是一个翻译后修饰，实际上可能决定MYH9是否容易“抓住”铜。
MYH9由1960个氨基酸组成，其中含有207个赖氨酸、123个精氨酸和28个组氨酸，整体表面具有较明显的正电特征，而铜离子本身同样带正电。赖氨酸乙酰化能够中和部分正电荷，从而减弱铜与MYH9之间的静电排斥。
DLAT释放 → MYH9乙酰化 → 铜结合增强 → MYH9聚合
因此，DLAT的作用可以理解为提高MYH9对铜的敏感性。
MYH9聚合之后，细胞为什么会死？
MYH9本身就是一种重要的肌动蛋白结合蛋白，因此研究人员继续追踪了肌动蛋白细胞骨架（actin cytoskeleton）。
结果非常清楚。
铜死亡发生时，丝状肌动蛋白（F-actin）减少，球状肌动蛋白（G-actin）增加；原本完整的F-actin纤维网络明显瓦解。同时，MYH9与actin之间的结合增强，并形成聚集结构。
但敲低MYH9后，这些变化大幅减弱，F-actin结构得以保存。
研究人员进一步删除MYH9负责结合actin的 83–764氨基酸区域。即使细胞接受铜刺激，只要MYH9无法正常结合actin，细胞骨架就不容易发生相同程度的崩塌，铜死亡也受到影响。
换句话说，MYH9聚合并不是单纯形成一些“蛋白团块”。这些聚合物会进一步招募并限制actin，干扰G-actin向F-actin的正常组装，最终造成细胞骨架失稳。细胞因此逐渐收缩成铜死亡中具有特征性的球形。
铜失衡 → DLAT参与MYH9乙酰化 → MYH9结合铜并聚合 → actin动力学失衡 → 细胞骨架崩塌 → 铜死亡
这也是这项研究对既往模型的重要补充：铜死亡不仅涉及线粒体代谢蛋白异常，还存在一个更接近细胞结构毁损的下游执行阶段。
一个更有意思的问题：一定要把外面的铜运进来吗？
此前很多铜死亡研究依赖铜离子载体。
这种思路很直接：把更多铜从细胞外带进细胞，推高胞内铜负荷。
问题也同样明显——铜并不会只进入肿瘤细胞。过量铜可能干扰正常组织的金属稳态，因此治疗窗可能受到限制。
研究人员于是从化合物库中筛选出 hexyl 2-(3,4,5-trihydroxy-phenyl) acetate（HThPA）。
它的特点十分特殊。
HThPA并没有明显提高细胞的总铜含量，却能够显著提高游离铜（free copper）水平。即使在无血清、缺乏外源铜补充的环境下，它仍然能够诱导MYH9聚合和铜死亡。
也就是说，HThPA不是把新的铜运进细胞，而是在利用细胞原本已经储存的铜。
细胞里原本就有的铜，能不能被重新释放出来？
这把问题从“如何增加铜”改成了另一个方向。
HThPA做的第一件事，是动摇GSH这座“铜储库”
细胞内的铜很少以完全游离状态存在，大量铜与谷胱甘肽（glutathione，GSH）、金属硫蛋白（metallothionein，MT）等分子结合。
HThPA作用后发生了一系列具有时间顺序的变化。
在A375细胞中使用 15 μM HThPA 后，研究人员在1小时检测GSH，3小时检测游离铜，8小时检测MYH9乙酰化，12–16小时观察MYH9聚合和细胞骨架变化，24小时检测ATP水平。
GSH下降在前，游离铜增加随后出现，再之后才是MYH9乙酰化、聚合、细胞骨架破坏和能量衰竭。
这一时间顺序非常关键，因为它与机制链条高度一致。
更有说服力的是，当研究人员补充可进入细胞的GSH衍生物后，游离铜释放受到抑制，铜与MYH9结合减少，MYH9聚合、细胞骨架破坏以及铜死亡也随之被阻断。
因此，单纯说“HThPA降低GSH”还不够准确。更完整的解释是：GSH下降改变了细胞内铜的结合状态，使原本被缓冲的铜转变为更容易参与反应的游离铜池。
从HThPA到铜释放，中间还有一条Nur77–PDK1–CHAC1通路
HThPA究竟如何降低GSH？
研究人员通过化学探针、蛋白质组学以及基因敲除，最终锁定了核受体 Nur77。
随后通过X射线晶体学解析出HThPA与Nur77配体结合结构域（ligand-binding domain，LBD）的复合物，分辨率达到 2.01 Å。HThPA与Nur77的T513、Q528等残基形成相互作用；对相关结合位点进行突变后，HThPA诱导铜死亡的能力明显受损。
但Nur77并不是直接降解GSH。
HThPA结合后，Nur77在胞质中充当一种蛋白复合体的组装平台，使PDK1更容易接触并磷酸化 CHAC1。后者是一种参与GSH降解的酶。
HThPA → Nur77 → PDK1 → CHAC1 → GSH下降 → 游离铜增加
游离铜增加 → DLAT促进MYH9乙酰化 → MYH9结合铜并聚合 → actin骨架破坏 → 铜死亡
从小分子靶点到细胞死亡表型，这项研究建立了一条相对完整的因果链。
最反常识的一幕：耐药肿瘤可能因为“铜更多”而更容易被攻击
如果HThPA依赖的是细胞已有的铜，那么一个很自然的问题就是：哪些肿瘤细胞内部的铜更多？
研究人员比较了7组获得耐药性的肿瘤细胞与相应亲本细胞，包括黑色素瘤A375、肺癌A549、口腔鳞癌KB、胃癌HGC-27和AGS，以及肝细胞癌SNU-182和Hep-3B，覆盖了dabrafenib/trametinib、紫杉醇、长春新碱、顺铂和仑伐替尼等不同耐药背景。
结果显示，这7组耐药细胞的总铜水平都高于相应亲本细胞，而且HThPA在这些高铜耐药细胞中更容易诱导MYH9聚合和细胞死亡。
研究中还有一个很有价值的反向验证：阿霉素耐药的K562细胞与亲本细胞之间铜水平没有明显差别，相应地，HThPA也没有表现出相同的“耐药细胞更敏感”现象。
这让“铜水平”与“HThPA敏感性”之间的联系更值得关注。
临床样本也出现了相同方向的信号
细胞系容易产生实验室特异性，因此研究人员进一步检测了人类肿瘤样本。
胃癌样本共 23例：15例化疗敏感，8例耐药
肝细胞癌样本共 17例：9例治疗敏感，8例治疗耐药
两种肿瘤中，耐药患者样本的铜含量均高于敏感患者。来源于耐药胃癌患者的原代肿瘤细胞也具有更高的胞内铜，并对HThPA诱导的MYH9聚合和铜死亡表现出更强反应。
需要强调的是，这里的临床样本量仍然较小，因此目前更适合把“胞内铜水平”理解为一个值得进一步验证的潜在生物标志物（biomarker），而不是已经成熟的患者分层指标。
耐药形成的代价，可能成为新的治疗弱点
为什么耐药肿瘤会积累更多铜？
这项研究没有给出确定答案。
研究人员提出一种可能解释：耐药细胞通常需要更强的抗氧化防御，而GSH和铜依赖的超氧化物歧化酶1（SOD1）都参与这一体系。提高铜储备可能有助于细胞承受长期治疗带来的压力。
如果这一解释成立，就会形成一个很有意思的生物学矛盾。
在获得耐药性的过程中，肿瘤细胞提高抗氧化和代谢适应能力；与此同时，却可能积累更多铜。平时，这些铜被GSH等分子妥善结合，并不造成明显毒性。
但HThPA降低GSH后，这部分原本有利于耐药细胞生存的铜储备，可能迅速转化成促进MYH9聚合的游离铜。
一种帮助肿瘤适应治疗压力的代谢特征，因此可能被转化成新的脆弱点。
这属于目前数据支持下的机制推断，仍需要更大的临床队列进一步验证。
比“杀死肿瘤”更重要的是：能否避开系统性铜过载
这项研究还有一个值得注意的结果。
在小鼠模型中，外源性铜离子载体ES联合铜虽然能够抑制肿瘤，但伴随体重下降，以及BUN、ALT、AST和CKMB等肾脏、肝脏和心肌损伤相关指标异常。
相比之下，HThPA同样能够诱导MYH9聚合并抑制移植瘤生长，但实验中没有观察到同等程度的器官毒性信号。
这并不能直接说明HThPA在人类中“安全”。
目前的数据主要来自细胞和动物模型，距离药代动力学、长期毒理、治疗窗以及人体临床试验还有很长距离。但它至少提示了一个重要方向：与其不断向细胞输入更多铜，也许可以尝试重新分配肿瘤细胞自身已有的铜。
这项研究改变的，不只是铜死亡的一张通路图
如果只把该研究理解为“又发现了一条铜死亡信号通路”，可能低估了它的意义。
过去的铜死亡模型主要围绕线粒体脂酰化蛋白聚集和铁硫簇蛋白丢失展开；这项研究进一步把机制延伸到了细胞骨架，提出MYH9聚合可能承担了一个更接近死亡终点的执行功能。
与此同时，它把“铜从哪里来”也拆成了两种不同模式。
一种是铜离子载体从细胞外输入铜；另一种则是HThPA通过 Nur77–PDK1–CHAC1–GSH 通路，从细胞内部已有的铜储库中释放铜。
DLAT介导MYH9乙酰化 → 铜结合MYH9 → MYH9聚合 → actin骨架崩塌
两条路线最终汇合到同一个节点。
这使铜死亡从一个主要围绕线粒体代谢异常的模型，逐渐扩展成一套连接金属稳态、蛋白翻译后修饰、细胞骨架和肿瘤耐药的完整生物学过程。
但距离把“高铜耐药肿瘤”变成治疗策略，还有几个问题必须回答
首先，虽然Cys896和Cys1834已经被证明对于MYH9结合铜和聚合十分重要，但铜结合的化学计量以及聚合物的具体化学结构仍然不清楚。
其次，HThPA通过降低GSH释放游离铜的机制已经在细胞实验中得到较充分验证，但这种机制是否自然存在于生理或病理状态下，目前仍没有答案。
第三也是一个关键技术问题：研究人员可以在细胞层面分别检测总铜、游离铜和MYH9结合铜，但受现有技术限制，无法在小鼠组织和临床肿瘤样本中直接检测游离铜。因此，从“耐药肿瘤总铜升高”到“体内游离铜增加并驱动MYH9聚合”之间，仍缺少最直接的一环证据。
所以，现在还不能简单得出“肿瘤铜越高，HThPA治疗效果就一定越好”的结论。
当肿瘤为了耐药而重新塑造代谢，它获得的每一种生存优势，是否同时也留下了可以被利用的代谢弱点？
对于铜死亡而言，MYH9可能正是把这种弱点转化为细胞死亡的关键执行节点。而耐药肿瘤内部积累的铜，也许不只是耐药的伴随现象——它可能成为下一步寻找治疗机会的重要线索。
参考文献
Wu LZ, Mi XY, Liu ZJ, Ding Y, Hong WB, Cai CX, Hu HJ, Ai YL, Zhao BX, Qiu DD, Ma JS, Chen XQ, You H, Lin T, Li FN, Hong XH, Chen HZ, Wu Q. Copper ion-induced MYH9 polymerization executes cuproptosis. Cell. 2026 Sep 14:S0092-8674(26)01003-2. doi: 10.1016/j.cell.2026.08.030. Epub ahead of print. PMID: 42735689.
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 乙醇中毒 | 日本 | 1951-08-28 | |
| 酗酒 | 美国 | 1951-08-28 |
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 进行性纤维化间质性肺病 | 临床2期 | 日本 | 2023-02-20 | |
| 酒精使用障碍 | 临床1期 | 美国 | 2025-09-15 |
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临床结果
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| 研究 | 分期 | 人群特征 | 评价人数 | 分组 | 结果 | 评价 | 发布日期 |
|---|
N/A | 113,000,000 | 鹽鏇衊願廠壓齋簾鏇簾(襯觸憲衊醖醖憲鬱簾選) = 窪齋窪鹹夢糧築觸築醖 積積鹽鹹鹹壓獵獵繭壓 (醖齋範遞選築醖糧膚夢 ) 更多 | 积极 | 2025-11-07 | |||
鹽鏇衊願廠壓齋簾鏇簾(襯觸憲衊醖醖憲鬱簾選) = 夢觸構膚構構襯繭艱衊 積積鹽鹹鹹壓獵獵繭壓 (醖齋範遞選築醖糧膚夢 ) 更多 | |||||||
N/A | 39,182 | 鬱願鹽積憲顧選鹹鑰鏇(鑰襯衊廠積願蓋鑰獵鏇) = 遞構糧鑰糧鹽願鹽構願 選糧餘齋範選願願糧觸 (憲網顧艱醖蓋鹽膚鹽醖, 4.07 ~ 4.54) 更多 | 积极 | 2024-11-15 | |||
鬱願鹽積憲顧選鹹鑰鏇(鑰襯衊廠積願蓋鑰獵鏇) = 範積鹽淵願衊艱鹹顧範 選糧餘齋範選願願糧觸 (憲網顧艱醖蓋鹽膚鹽醖, -0.02 ~ 1.56) 更多 | |||||||
N/A | 206,252 | Pharmacological cessation therapies | 顧鏇築膚築蓋鹽鏇夢蓋(選壓鏇廠廠顧夢鑰齋選) = 鹽鹽鬱築夢壓築築淵鏇 蓋艱壓壓淵鹽構膚構齋 (憲鏇獵糧憲襯鏇窪夢鹹 ) 更多 | 积极 | 2024-11-15 | ||
N/A | - | 願顧網獵繭鬱廠鬱顧範(糧鏇顧壓獵壓鹽鏇構鹹) = the rate of AUD medication discontinuation for adverse events was similar in both groups (14% vs 12%) and none were stopped due to suspected DILI 繭襯壓膚淵餘顧憲糧餘 (顧鹹築鏇製網構膚簾鏇 ) 更多 | - | 2024-05-20 | |||
临床2期 | 1,191 | 鹽蓋襯積繭襯遞衊憲醖(膚選鬱鹹製選鏇鑰範淵): RR = 1.2 (95% CI, 0.92 ~ 1.55) 更多 | 积极 | 2024-01-05 | |||
Placebo | |||||||
临床2期 | 11 | (Cohort 1: Disulfiram 100 mg) | 獵遞齋膚醖鬱遞積觸築(廠觸鹽醖鏇糧繭觸鑰築) = 築壓壓網觸齋選糧襯艱 範選窪艱艱獵淵餘淵艱 (積築齋簾蓋鏇糧積艱醖, 範齋糧廠蓋遞鏇獵積衊 ~ 壓窪繭願窪製繭願艱窪) 更多 | - | 2023-09-13 | ||
placebo+disulfiram (Cohort 1: Placebo) | 獵遞齋膚醖鬱遞積觸築(廠觸鹽醖鏇糧繭觸鑰築) = 淵簾築製餘鑰醖衊獵糧 範選窪艱艱獵淵餘淵艱 (積築齋簾蓋鏇糧積艱醖, 積構淵鏇積顧願齋獵願 ~ 襯壓製餘積鹽簾廠齋壓) 更多 | ||||||
临床4期 | 41 | 壓範鏇簾膚餘構鏇鹹夢 = 壓製構襯廠憲夢憲顧鬱 窪鑰襯廠窪壓廠壓餘膚 (鏇壓蓋願衊憲壓積糧顧, 鑰醖觸鹹襯獵遞廠醖獵 ~ 遞顧襯範淵網積獵簾鹽) 更多 | - | 2023-08-30 | |||
临床1/2期 | 52 | placebo (Placebo) | 齋鏇襯築餘膚齋構夢願(遞鹽襯範鬱淵艱夢網廠) = 獵遞餘獵獵繭網積觸糧 窪餘醖糧鹽膚選夢築築 (糧繭壓蓋鏇鑰構夢膚鬱, 0.5) 更多 | - | 2023-07-19 | ||
(Disulfiram Treatment Group) | 齋鏇襯築餘膚齋構夢願(遞鹽襯範鬱淵艱夢網廠) = 夢積衊衊繭糧積憲築糧 窪餘醖糧鹽膚選夢築築 (糧繭壓蓋鏇鑰構夢膚鬱, 0.8) | ||||||
临床1/2期 | 11 | (8 Week Disulfiram) | 餘繭憲壓衊鏇憲艱廠醖 = 製願壓齋築餘廠艱糧構 簾選築選繭鬱鏇鏇觸壓 (夢夢鹹築壓築網構簾選, 憲製範鏇襯艱齋鑰鑰淵 ~ 鑰製襯窪蓋積築膚鹹願) 更多 | - | 2023-06-05 | ||
(4 Week Disulfiram) | 餘繭憲壓衊鏇憲艱廠醖 = 築廠鹽範顧鏇鹹窪積餘 簾選築選繭鬱鏇鏇觸壓 (夢夢鹹築壓築網構簾選, 選襯繭築艱顧襯艱製艱 ~ 鑰淵齋選鬱醖製築觸齋) 更多 | ||||||
临床2/3期 | 88 | Standard-of-care alkylating chemotherapy alone | 鑰積壓繭鑰蓋憲顧範遞(遞餘構艱範鬱衊繭膚簾) = 製襯顧簾遞糧憲齋襯積 繭淵衊鬱網壓窪鹽膚簾 (遞糧窪鹽網膚襯簾築鹽, 5.4 ~ 10.2) 更多 | 不佳 | 2023-03-01 | ||
鑰積壓繭鑰蓋憲顧範遞(遞餘構艱範鬱衊繭膚簾) = 製遞衊獵鑰糧網觸衊淵 繭淵衊鬱網壓窪鹽膚簾 (遞糧窪鹽網膚襯簾築鹽, 3.9 ~ 9.3) 更多 |
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