Guangzhou Yipinhong Pharmaceutical Co., Ltd.

Objective: To study the best inclusion process of the pogostemon cablin essential oil from Qinxiang Qingjie oral liquid with hydroxypropyl betacyl dextrin(HP-β-CD).Methods: The process conditions were screened by determining the inclusion rate of volatile oils and the yield of inclusion compoundOrthogonal design test was used to optimize the inclusion process, and the structure of the inclusion compound was characterized by GC, X-ray diffraction and IR.Results: the best preparation process of inclusion compound was as follows: the inclusion temperature was 35 °C, the inclusion time was 2.5 h, and the volatile oil of patchouli♂HP-β-CD=1♂12.The inclusion compound was formed and the composition of the volatile oil had no obvious change after inclusion.Conclusion: According to the optimized process, The complex prepared under the optimized process is stable, and that has the advantages of the highest inclusion rate, stable inclusion process and easily soluble in oral liquid

Objectives: To establish a HPLC method to determine the content of ephedrine hydrochloride and pseudoephedrine hydrochloride in Fuganlin oral liquidMethods: The chromatog. conditions was as follows: Phenomenex Synergi Polar-RP column (250 mm × 4.6 mm, 4μm), methanol-0.092% phosphoric acid solution (containing 0.04% triethylamine and 0.02% di-n-butylamine) (1.5:98.5) as the mobile phase, flow rate being 1.0 mL · min^-1, detection wavelength set as 210 nm.Results: The linear range of ephedrine hydrochloride and pseudoephedrine hydrochloride was 1-100μg · mL^-1, and the average recovery (n = 6) was 97.43% (RSD = 0.80%) and 98.59% (RSD = 1.77%) resp.Conclusions: The method is simple, accurate and reliable, and can be used for the simultaneous determination of ephedrine hydrochloride and pseudoephedrine hydrochloride, which will provide a scientific basis for quality evaluation of Fuganlin oral liquid

Objective: To establish the process conditions which are suitable for the large-scale production of Compound Amino Acid Injection (18AA), and to ensure the stability of product quality.Methods: Through the screening of the production process conditions which can affect the quality of Compound Amino Acid Injection (18AA), and to determine the conditions of the optimal dosage of activated carbon, sterilization time, sterilization temperature and whether nitrogen.Results: The optimal conditions were as follow: filled with nitrogen, the activated carbon dosage of 0.05%, the sterilization temperature of 121°C and the sterilization time of 10 min.Conclusions: The established process conditions are suitable for the production of this product, which is reasonable and scientific.