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The objective of this research was to investigate the effect of concentration and delivery system on skin permeation of α-tocopherol (α-T).Also, the addition of sunscreens and oleic acid on α-T permeation was studied using an in vitro micro-Yucatan pig skin model.Various delivery systems of α-T (1%) were formulated, which included simple solution, gels, emulsions, and microemulsions.The exptl. design chosen for this study was a statistical randomized complete block design.α-T delivery was proportional to its concentrationThe hydroalcoholic gel delivered significantly higher amounts of α-T into the receptor than the other gels used.A microemulsion containing iso-Pr myristate emerged as the best delivery system for α-T among all the systems studied.Pig skin is a suitable in vitro model for studying the permeation of α-T and possibly other antioxidants, though in vivo experiments in humans are required to further corroborate the data.

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