别名 巨噬细胞集落刺激因子、colony stimulating factor 1、colony stimulating factor 1 (macrophage) + [9] |
简介 Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance. |
作用机制 FGFRs拮抗剂 [+2] |
在研机构 |
原研机构 |
最高研发阶段临床2期 |
首次获批国家/地区- |
首次获批日期1800-01-20 |
作用机制 M-CSF激动剂 [+3] |
在研机构 深圳未知君生物科技有限公司初创企业 [+2] |
原研机构 |
非在研适应症- |
最高研发阶段临床2期 |
首次获批国家/地区- |
首次获批日期1800-01-20 |
靶点 |
作用机制 M-CSF抑制剂 |
在研机构 |
在研适应症 |
最高研发阶段临床1/2期 |
首次获批国家/地区- |
首次获批日期1800-01-20 |
开始日期2024-04-01 |
开始日期2024-01-30 |
申办/合作机构 |
开始日期2023-08-02 |
申办/合作机构 |